Ok, you have posted to every internet job board and every job on Monster, CareerBuilder, and HotJobs. You've followed up with calls and networked until you are blue in the face. Each Sunday you take the newspaper and apply for every job in your field with little to no results. Well try some unique ways to find a job.
Find a company you want to work. Write a great cover letter on why you are a good fit, pointing to the enclosed resume. Don't seal the envelope and don't enclose a resume. They'll think the resume fell out in the mail. They will call and engage in a conversation. Sell yourself shamelessly.
Create a list of 20 companies you want to work for and send an email to everyone you know to see if they know anyone who works at these companies. Ask them to contact you if they do, so that you can ask for a referral. Finally, ask them to forward your email to 10 more people. However don't do this if you're currently employed!