cells of the monocyte-macrophage DC lineage and subsets of tissue-resident DCs and epidermal Langerhans cells. In addition to supporting leukocyte extravasation from the blood, the CX3CL1–CX3CR1 axis has been implicated in pathogenesis of inflammatory diseases such as atherosclerosis, rheumatoid arthritis, and renal fibrosis. CX3CL1 was also shown to promote extension of transepithelial dendrites by monocytes and/or DCs within intestinal lamina propria, for the purpose of antigen sensing in the intestinal lumen.
Additional information: Clone REA281 displays negligible binding to Fc receptors.