Chang’s clinical research focuses on development of endoscopic modalities for cancer diagnosis, staging and therapy. He has pioneered the development of EUS-guided fine-needle aspiration and EUS-guided fine-needle injection. He is the author of more than 200 publications and book chapters regarding the technique’s use in gastrointestinal malignancies. He has conducted numerous clinical trials on the development of new biologic agents against esophageal and pancreatic cancers.
Chang completed his medical degree and residency at Brown University in Providence, R.I. He then finished a fellowship in gastroenterology at UC Irvine Medical Center and the UC Irvine School of Medicine, where he has been a faculty member for more than 25 years. He is director of the UCI Health H.H. Chao Comprehensive Digestive Center and the School of Medicine's chief of Gastroenterology and Hepatology.