Akers signed with the Carolina Panthers as an undrafted free agent in 1997 but was cut in the preseason. He also failed in a preseason trial with Atlanta in ’98, but was added to Washington’s practice squad and activated for one game in which he kicked his first two NFL extra points but missed both of his field goal attempts and was released. Signed by the Eagles after the season, Akers played for the Berlin Thunder of NFL Europe in the Spring of 1999 and for Philadelphia in the Fall, used for kickoffs and long-distance field goals while Norm Johnson handled the regular placekicking duties. He connected on three of six field goal tries, with a long of 53 yards at Miami. Akers took over as full-time placekicker in 2000 and was successful on 29 of 33 field goal attempts and set a team record with 121 points.
Eagles went 11-5 to finish first in NFC East. Won NFC Wild Card playoff over Tampa Bay Buccaneers (31-9) and NFC Divisional playoff over Chicago Bears (33-19). Lost NFC Championship to St. Louis Rams (29-24).
Akers remained with the Eagles for another nine years. During that stretch, he led the NFC in scoring four times and the entire NFL once, topped the NFC in field goals twice, and was named to the Pro Bowl five times. With a strong left leg, he was known for his long kickoffs as well as field goal kicking. He missed four games with a severe hamstring injury in 2005 and his field goal accuracy dipped under 80 percent for the first of three straight years. However, Akers bounced back to kick a club-record 33 field goals in 2008 and was named to the Pro Bowl in each of his last two years in Philadelphia. By the end of the 2010 season, his last with the Eagles, he owned most of the major franchise career placekicking records, including field goals (294) and scoring (1323 points). He signed with the 49ers in 2011 and set NFL records with 44 field goals in 52 attempts and a total of 166 points, the most in league history with no touchdowns included. However, Akers connected on only 69 percent of his field goal attempts in 2012, although one of them tied the then-league record of 63 yards. Released by the 49ers, he last kicked for Detroit in 2013. Overall, Akers was successful on 386 field goals in 477 attempts (80.9 %) and added 563 extra points for a total of 1721 points. In the postseason, he added another 39 field goals in 47 tries (83 %) and twice appeared in the Super Bowl.