CLI is an urgent condition caused by chronic blockages of the arteries which significantly reduces blood flow to the legs, hands and feet. This type of poor circulation can cause severe pain in your feet, toes and hands, even while resting. Complications of poor circulation can include sores and wounds that won’t heal. Left untreated, you are at high risk for skin breakdown, infection, and even amputation of the limb. This serious condition requires immediate treatment to prevent limb loss and to improve your quality of life.