Dr. Brian Xu is a board-certified toxicologist with Bergeson & Campbell, P.C. (B&C®) who assists clients in developing and managing international projects involving U.S. Food and Drug Administration (FDA) and U.S. Environmental Protection Agency (EPA) regulated consumer products, cosmetics, industrial and specialty chemicals, agrochemicals, and antimicrobials. Dr. Xu is also an M.D. in pathology, holds a Ph.D. in pharmacology and toxicology, and has over 15 years of industry experience as a senior toxicologist and scientist at companies such as Ashland, Inc., Schering-Plough, and Merck.
Dr. Xu joined B&C from Ashland, Inc. where he served as Senior Product Regulatory Toxicologist for Environmental Health and Safety, but he began his scientific career at the Chinese Academy of Medical Sciences as a physician at the Cancer Institute and Hospital in Beijing, China, specializing in cancer pathology. He moved to the U.S. in 1991 to continue his education at George Washington University for his doctorate, from whence he proceeded to Yale, where he was a Post-doctoral Fellow in Pharmacology. His professional career has included time at Merck as a Senior Research Biologist and core member of the gene expression technology working group; Schering-Plough, where he was Principal Scientist and Toxicologist in the Department of Drug Safety and Metabolism; and Enzon Pharmaceuticals, where he was Director of Toxicology and Preclinical Pharmacokinetics.
Provided to a major multinational company toxicology and regulatory expertise in therapeutic and diagnostic products that combine drugs, devices, and biological elements.
Inspected China testing facilities for compliance with GLP Standards to ensure the integrity and regulatory acceptance of health and environmental safety studies.
Conducted environmental health and safety (EHS) audit of China manufacturing facility for a multinational company.
Klumpp, K., Dunn, J., Heilek, G., Zhou, A., Stefanidis, D., Chen, C., Xu, J., et al. 2007. "R1206, a representative of a new class of potent diphenylether non-nucleoside reverse transcriptase inhibitors broadly active against NNRTI resistant HIV-1 variants and achieving high systemic exposures and benign safety profiles in animal species." 14th Conference on Retroviruses and Opportunistic Infections.
Nantermet, P.V., Masarachia, P., Gentile, M.A., Pennypacker, B., Xu, J., et al. 2005. "Androgenic Induction of Growth and Differentiation in the Rodent Uterus Involves the Modulation of Estrogen-Regulated Genetic Pathways." Endocrinology 146; 564-78.
Nantermet, P.V., Xu, J., Yu, Y., et al. 2004 "Identification of genetic pathways activated by the androgen receptor during the induction of proliferation in the ventral prostate gland." J. Biol. Chem. 279:1310-22.
Wang, H., Sun, H., Della, Penna K., Benz, R.J., Xu, J., et al. 2002. "Chronic neuropathic pain is accompanied by global changes in gene expression and shares pathobiology with neurodegenerative diseases." Neuroscience 114:529-46.
Sun, H., Xu, J., Della ,Penna K.B., et al. 2002. "Dorsal horn-enriched genes identified by DNA microarray, in situ hybridization and immunohistochemistry." BMC. Neurosci. 3:11.
Gerhold, D.L., Liu, F., Jiang, G., Li, Z., Xu, J.,et al. 2002. "Gene expression profile of adipocyte differentiation and its regulation by peroxisome proliferator-activated receptor-gamma agonists." Endocrinology 143:2106-18.
Gerhold, D.L., Xu, J., Rushmore, T. 2003. "Microaarays in Drug Metabolism and Toxicology: Rat Liver Responses to Prototypical CYP Inducers." In: Burczynski, ed., An Introduction to Toxicogenomics, CRC Press, pp. 101-115.
Elbrecht, A., Chen, Y., Xu, J., et al. 2001. "Compound Characterization Using Gene Microarrays." JALA 6:71-75.
O'Brien, T., Xu, J., Patierno, S.R. 2001. "Effects of glutathione on chromium-induced DNA crosslinking and DNA polymerase arrest." Mol. Cell. Biochem. 222:173-82.
Gerhold, D., Lum M,, Xu, J., Austin, C., Caskey, C.T., Rushmore, T. 2001. "Monitoring expression of genes involved in drug metabolism and toxicology using DNA microarrays." Physiol. Genomics 5:161-70.
Xu, J., Xiao, H.H., Sartorelli, A.C. 1999. "Attenuation of the induced differentiation of HL-60 leukemia cells by mitochondrial chaperone HSP70." Oncol Res. 11:429-35.
Xu, J., Bubley, G.J., Detrick, B., Blankenship, L.J., Patierno, S.R. 1996. "Chromium(VI) treatment of normal human lung cells results in guanine-specific DNA polymerase arrest, DNA-DNA cross-links and S-phase blockade of cell cycle." Carcinogenesis 17:1511-7.
Xu, J., Manning, F.C., Patierno, S.R. 1994. "Preferential formation and repair of chromium-induced DNA adducts and DNA--protein crosslinks in nuclear matrix DNA." Carcinogenesis 15:1443-50.
Xu, J., Wise, J.P., Patierno, S.R. 1992. "DNA damage induced by carcinogenic lead chromate particles in cultured mammalian cells." Mutat. Res. 280:129-36.
“Forecast of China, US, and EU Chemical Regulation in 2018,” AsiaHub Summit Europe 2018, Brussels, Belgium, (September 27, 2018).
“Forecast of China, USA, and EU Chemical Regulation in 2018,” AsiaHub Summit USA 2018, San Francisco, California (February 26, 2018).
“Reforming the US Toxic Substances Control Act - latest developments,” Chemical Watch Regulatory Summit, Hong Kong (September 8, 2016).
“Relevant Regulatory Framework in China for Industry - Updates and developments,” ChemCon The Americas 2016, Toronto, Canada (October 21, 2016).
"K-REACH: What You Need to Know to Do Business in South Korea in 2015," Bergeson & Campbell, P.C. Webinar (December 4, 2014).
"Regulations for Industrial Chemicals in China -- An Industry View," ChemCon The Americas 2014, Chicago, Illinois (October 27-31, 2014).
"Chemical Regulation in the USA -- Important Developments," Chemical Watch Regulatory Summit Asia, Singapore (September 3, 2014).