19-year-old James Hamon makes his first Football League start for the Grecians, with Christy Pym taking a place on the bench.
Captain Scot Bennett misses out after picking up an injury in last weekend’s fixture at Newport, meaning that the armband will be worn by Matt Oakley.
Jimmy Keohane comes into the starting XI in his place, with Tom Nichols and Graham Cummins starting in attack.
Arron Davies comes back into the matchday squad and takes a seat on the bench.
Exeter City: Hamon; Ribeiro, Butterfield, Oakley, Woodman; Noble, Grimes, Sercombe, Keohane; Nichols, Cummins.
Subs: Pym, Davies, Wheeler, Riley-Lowe, Tillson, Jay, Watkins.
Shrewsbury Town: Leutwiler; Grimmer, Knight-Percival, Goldson, Grandison, Demetriou; Woods, Wesolowski, Lawrence; Akpa Akpro, Collins.
Subs: Halstead, Ellis, Clark, Vernon, Grant, Griffith, Vincent.