Round 4 of the Capital One Cup is being held this week with five ties taking place on Tuesday, before another three on Wednesday.
Shrewsbury Town are the lowest-ranked side left in the competition and they are at home against Premier League leaders Chelsea.
The Shrews moved up to fourth in Sky Bet League 2 on Saturday with a victory against Portsmouth and they've overcome Blackpool, Leicester City and Norwich City to earn their Cup clash with Jose Mourinho's men, who come into the game after a 1-1 draw with Manchester United at Old Trafford.
This will be the first time the two clubs have met in the League Cup and the Sky Sports cameras will be at the expanded Greenhous Meadow to capture all the action, with kick-off at 7:45pm.
There's an all-Sky Bet League 1 encounter at stadiummk, where Milton Keynes Dons host Sheffield United.
Karl Robinson's Dons have made the Fourth Round after three home victories in the competition, including a memorable 4-0 success against Manchester United. The Blades, meanwhile, beat Mansfield Town and Leyton Orient, and needed penalties to see off West Ham United.
Kit Symons enjoyed his first win as Fulham's caretaker manager in Round 3, against Doncaster, and after four victories over the six matches since, his side host Sky Bet Championship leaders Derby County.
Bournemouth are also going well in the Championship, winning 8-0 at Birmingham City on Saturday to record their biggest win ever, and they entertain West Bromwich Albion on the south coast.
Elsewhere on Tuesday, Liverpool boss Brendan Rodgers welcomes his former employers Swansea City to Anfield. The Swans triumphed 3-1 against the Reds the last time these two sides met in the League Cup, in October 2012, and they went on to lift the famous trophy that season, beating Bradford City 5-0 in the Final at Wembley.
Newcastle United and Manchester City locked horns at this stage of the Capital One Cup last season and they will clash again at the Etihad on Wednesday, live on Sky Sports.
City won their Fourth Round tie 2-0 a year ago, on their way to winning the competition, and they've since recorded two more 2-0 successes in the Premier League against the Magpies.
Another all-Premier League clash on Wednesday sees Stoke City and Southampton go head-to-head, while Sami Hyypia takes his struggling Brighton & Hove Albion side to Tottenham Hotspur. The Seagulls' 3-0 Round 3 victory against Burton is their only win in their last 11 outings.