Several full-time postdoctoral positions are immediately available for MD and/or Ph.D graduates. Please state the name of the lab that you are applying to in the email subject.
Two research assistant positions are available in the Jha laboratory to study the role of chromatin remodeling complexes in cancer prevention. We are particularly interested in studying the changes in chromatin signature due to deregulation of these remodeling complexes and how these alterations in genome organization lead to the transformation of cells from a normal to a cancerous state. The successful candidate will investigate the role of the chromatin remodeling complexes in the maintenance of histone code and tumor suppression at protein and genome-wide level using cells in culture and knockout mouse techniques.
Candidates should have a BSc Degree with experience in the epigenetics and chromatin biology.
We are seeking a highly motivated candidate as a research assistant in the Kappei lab and the Quantitative Proteomics Core at the Cancer Science Institute of Singapore. Our young and international team addresses research questions on nucleic acid-protein interactions with quantitative mass spectrometry, cell biological and genetic approaches applied to cancer research and we further support research activities at CSI as part of the Quantitative Proteomics Core with quantitative proteomics solutions to study e.g. protein expression profiling, protein-protein interactions as well as post-translational modifications. The research assistant will develop analysis pipelines applied to proteomics datasets and will pursue projects at the interphase of proteomics, genomics, biochemistry, cell biology and cancer research.
We are seeking a highly motivated candidate as a research fellow in the Kappei lab and the Quantitative Proteomics Core at the Cancer Science Institute of Singapore. Our young and international team addresses research questions on nucleic acid-protein interactions with quantitative mass spectrometry, cell biological and genetic approaches applied to cancer research and we further support research activities at CSI as part of the Quantitative Proteomics Core with quantitative proteomics solutions to study e.g. protein expression profiling, protein-protein interactions as well as post-translational modifications. The research fellow will develop analysis pipelines applied to proteomics datasets and will pursue projects at the interphase of proteomics, genomics, biochemistry, cell biology and cancer research.
The Transgenic and Gene Targeting Facility (TGTF) is a joint operation between CSI and the Comparative Medicine (CM) animal facility at NUS. The Facility operates as a “business” where customer-service and project-management skills are paramount.
The Deputy Head of the Facility is responsible for oversight and to provide day to day management of the TCF on routine technologies such as embryo rederivation or cryo-conservation (embryo- and sperm freezing) as well as, on established and novel technologies enabling generation of new mouse models, including ES-cell injection, pronucleus injection (transgenic mouse models) and gene-editing via CRISPR/Cas9 (both on ES-cells and via electroporation into embryos).
Responsible to maintain an adequate number of animals by setting up breeding pairs, manage breeding rotations and setting up timed pregnancies.
Perform as well as supervise Facility team in other technical research procedures (dosing, injections, sample collections, etc.) and husbandry activities as needed.
Good skills and in-depth hands-on experience in molecular techniques related to cloning and genome editing via CRISPR/Cas9.
3 to 5 years of relevant experience working with transgenic animal models or equivalent combination of education and experience required.
Excellent demonstrated accuracy, attention to detail and work ethic is a must!
Must have a demonstrated ability to work independently, with minimal supervision.
A postdoctoral position is available in the Jha laboratory to study the role of chromatin remodeling complexes in cancer prevention. We are particularly interested in studying the changes in chromatin signature due to deregulation of these remodeling complexes and how these alterations in genome organization lead to the transformation of cells from a normal to cancerous state. The successful candidate will investigate the role of the chromatin remodeling complexes in the maintenance of histone code and tumor suppression at protein and genome-wide level using cells in culture and knockout mouse techniques.
Candidates should have a PhD in cancer biology or related area and prior experience working with mouse.
The position of Research Assistant/Associate (software engineer) is immediately available in the laboratory of Dr. Jason Pitt, which integrates data science and biological expertize to facilitate novel discoveries in cancer genomics. The Pitt Laboratory achieves this by developing cutting-edge software that allows cost-effective identification, harmonization, and interrogation of large genomic datasets. Collectively, we refer to this domain as genome economics. Successful candidates will interact closely with the Data Science and Learning Division of Argonne National Laboratory (USA) as well as our industrial partners. This position provides a rare opportunity to utilize Amazon Web Services, Amazon Alexa, data-intensive computing, natural language processing, and artificial intelligence.
Applications should include full curriculum vitae, publication list (if applicable), and contact information for 2-3 referees. Please also include single page cover letter summarizing your experience, programmatic expertise, and why this position is of interest to you.
A Research Assistant position is available immediately in Prof Toshio Suda’s lab at the Cancer Science Institute of Singapore, for a motivated scientist.
Assist primarily with cell culture and possibly, FACS experiments in the lab.
A Bachelor’s degree in Biology (Cellular/Molecular biology/ Genetics/ Biochemistry).
Prior experience in immunohistochemistry (IHC) staining is essential.
Proficiency in basic molecular and cellular biology techniques including cell culture, real-time PCR and western blotting.
Highly motivated individual with an inquisitive mind and have strong analytical, technical and problem-solving skills.
Applications should include full curriculum vitae (including personal particulars, academic and employment history, and current/expected salary), a complete list of publications/oral presentations and contact information of 2 referees.
A full-time Research Assistant/Laboratory Executive position will be available after February 2019. An applicant can choose either research track (Research Assistant) or executive track (Laboratory Executive).
University degree (biology, biomedical science, biotechnology or related area).
Ability to speak and write well in English.
Prior experience working with mouse or/and zebrafish model.
Knowledge of: 1) basic principles and practices in the fields of biology, 2) principles, techniques and terminology used in biology, 3) principles, techniques and terminology used in animal studies.
Appropriate computer operations, software and peripherals, including Microsoft Word, Excel and Powerpoint.
To maintain animal colonies including breeding.
To create transgenic and knockout animal models, and perform xenograft studies.
To isolate tissues from the animal and analyze by flowcytometry.
To harvest cells, protein, RNA or DNA.
To purify DNA, RNA or protein from cell lines or bacteria.
To perform experiments including cell culture, PCR, immunoprecipitation and Western blot.
To maintain a systematic and proper record of animals, including annual reports.
To liaise with the core facilities, committees and the administrative office to assist in research.
To liaise with the vendors to ensure proper purchase requisitions, goods delivery and prompt payment of supplies.
To be responsible for purchasing necessary chemicals, reagents and equipment as required by the lab or project.
To create and review standard operating procedures and risk assessments.
Responsible for the general cleanliness of the lab and core facility.
To assemble reagents, chemicals and media that are needed for experiments.
To ensure that standard operating procedures and safety regulations are followed.
Applications should include full curriculum vitae and 2-3 reference letters. Please note that only shortlisted candidates will be contacted.
We are seeking a highly motivated candidate with intention to pursue a PhD as a Research Assistant (Bioinformatics) in the Fullwood Lab. Our research interest is to better understand the role of 3D genome organization in the control of RNA Biology in Cancer. Specifically, we are looking for a candidate who will analyse chromatin interaction data (e.g. Hi-C, ChIA-PET, 4C, etc), related data (e.g. ChIP-Seq, RNA-Seq), present data and write manuscripts. The candidate will also assist in routine data management e.g. management of servers, as required. Candidates should be comfortable in working independently and with other team members, learning new things on their own and be willing to work in flexible schedules to manage workload on weekend or before/after normal working hours.
Experience in chromatin interaction data analysis and/or genomic and epigenomic data analysis is not required but is a plus.
Applications should include in a single PDF a cover letter, curriculum vitae, certificates of qualifications and the names and contact information of at least 3 professional references.
A full-time Research Assistant position is immediately available at the Bioinformatics Core, Cancer Science Institute of Singapore. The primary focus of our group is to analyze and integrate various genomic data for novel discoveries in cancer genomics. For this particular position, we are seeking highly motivated graduates who are interested in integration of human genomic data with microbiome data. The candidate will develop an integrative computational analysis platform for profiling interactions between human host and microbiome based on different genomics data.
Candidates should have a Bachelor’s degree in bioinformatics, computational biology or related fields. Knowledge and experience in genomics, genome sequence analysis, and transcriptome data analysis are required. Candidates should also have solid programming skills (e.g., Python, Perl, Java, R) as well as strong mathematical analytics background.
A postdoctoral position is available immediately in Dr Yvonne Tay’s lab for a highly motivated Ph.D. or M.D graduate with a background in molecular or cellular biology, biochemistry or other related fields who is interested in deciphering regulatory RNA networks in the context of cancer (reviewed in Tay et al, Nature 2014; also see Tay et al, Nature 2008 and Tay et al, Cell 2011). The successful candidate will design and conduct experiments, analyse data, write papers and grants, mentor students, and compete for fellowships.
A Ph.D. in cancer biology or related area.
Experience with in vivo animal models, particularly mice and/or zebrafish.
Expertise in RNA biology (including but not limited to microRNAs) is preferred.
Strong background and working knowledge of basic molecular and cellular biology techniques such as cell culture, cloning, real-time PCR and western blotting.
Experience with analyses of human clinical samples, RNA sequencing, RNA immunoprecipitation, mass spectrometry and/or CRISPR genome editing is highly desirable.
Ability to independently lead research projects and critically analyse data.
A proven track record in the form of publications in top international English language journals.
Applications should include full curriculum vitae, publication list, and names and contact information of 3 referees. Please also include a summary of your research experience.