With the loss, Rhody drops to 2-3 while Quinnipiac improves to 3-0.
Junior Emilie Cloutier led the Rams in scoring as she matched her career best with a game-high 18 points on the afternoon.
Freshmen Brianna Thomas and Tayra Melendez each added 10 points, marking the first time this season that Rhody finished with three players in double figures.
Thomas also added six rebounds, five assists and two steals in 34 minutes on the floor.
Senior Lara Gaspar led the Rams with eight rebounds. Melendez added six.
Quinnipiac connected on 9-of-20 (45%) attempts from long range as four different players hit at least one three-pointer for the Bobcats.
Rhode Island held a 40-37 rebounding advantage but committed 18 turnovers to Quinnipiac's 12.
Felicia Barron registered a team-high 17 points for Quinnipiac.
Rhody returns to Kingston for a Tuesday night meeting with Boston University. Tip-off is set for 7:00 p.m. at the Ryan Center. Rhode Island is 7-10 in the all-time series vs. the Terriers. The last time the teams met - on Nov. 26, 2011 - BU posted a 71-44 win in Boston. In that game, Emilie Cloutier (12) and Ajanae Boone led the Rams with 12 points apiece while recorded a team-high seven rebounds and five assists.