Metaglossary.com - Definitions for "biomarker"
(sometimes referred to as a metabolomic biomarker) is a biochemical characteristic that can be used to diagnose and measure the progress of disease.
molecular, biochemical, cytogenetic or histological changes that precede the development of cancer and that provide evidence for an increased risk of cancer in those individuals exhibiting a high frequency of the biomarker.
A molecular marker associated with a biological function.
A molecular indicator of environmental exposure (used in toxicology), disease (used as a diagnostic tool), or susceptibility to disease.
A distinctive biological or biologically derived indicator (as a biochemical metabolite in the body) of a process, event, or condition (as aging or exposure to a toxic substance) used to measure or indicate the effects or progress of a disease, illness, or condition.
A molecular indicator of a specific biological property; a biochemical feature or facet that can be used to measure the progress of disease or the effects of treatment.
any measurable sign (including visual and molecular) indicating the status of an organisms physiology, health, etc. that can be used in the diagnosis of a disease or syndrome4; includes a variety of measures of specific molecular, cellular, and physiological responses of key species to either contaminant exposure or poor health5.
Any consistently detectable biological molecule that is associated with a biological state, such as a disease.
A biomarker is any biomolecule that is associated with a particular pathological or physiological state. Protein biomarkers are often used to identify drug targets or to diagnose and monitor therapy.
A molecular indicator of a specific biological property or function. Biomarker levels can be measured to detect or monitor the course of disease or assess the effects of treatment.
1. Indicator signaling an event or condition in a biological system or sample and giving a measure of exposure, effect, or susceptibility. As related to biomonitoring, a biomarker is the presence of any substance, or a change in any biological structure or process that can be measured as a result of exposure. Many biomonitoring studies focus on chemical substances or their metabolites as biomarkers. 2. Parameter that can be used to identify and effect in an individual organism and can be used in extrapolation between species for risk assessment.
An objective, measurable biochemical parameter that faithfully reflects a critical pathway to a disease or a critical pathway that predisposes to a disease (ultimate or proximal critical pathways).
observable change (not necessarily pathological) in the function of an organism, related to a specific exposure or event.
A biological indicator that signals certain stresses or diseases in the body and gives a measure of exposure, effect, or susceptibility.
A specific, observable physical trait used to measure or indicate the effects or progress of a disease or condition.
A specific biochemical in the body which has a particular molecular feature that makes it useful for measuring the progress of disease or the effects of treatment.
Used to indicate or measure a biological process; for example, levels of a specific protein in blood or spinal fluid. Detecting biomarkers specific to a disease can aid in the identification, diagnosis, and treatment of affected individuals, as well as people who may be at risk but who do not yet have symptoms.
A chemical, biochemical, or functional indicator of exposure to (or the effect of exposure to) - an environmental chemical, physical or biological agent.
Parameter that can be used to identify a toxic effect in an individual organism and can be used in extrapolation between species. Indicator signalling an event or condition in a biological system or sample and giving a measure of exposure, effect, or susceptibility.
a physical, functional, or biochemical indicator (e.g., the presence of a particular metabolite) of a physiological or disease process.
A specific biological trait, such as the level of a certain molecule in the body, that can be measured to indicate the progression of a disease or condition.
A molecular marker that is associated with or identifies biological function.
any parameter that can be used to measure an interaction between a biological system and an environment agent, which may be chemical, physical or biological (WHO 1993).
Used to indicate or measure a biological process (for instance, levels of a specific protein in blood or spinal fluid, genetic mutations, or brain abnormalities observed in a PET scan or other imaging test). Detecting biomarkers specific to a disease can aid in the identification, diagnosis, and treatment of affected individuals and people who may be at risk but do not yet exhibit symptoms.
measure that is an indicator of a normal physiologic process, or a pathologic state or the response of an organism to an intervention that can be used in clinical research. When a biomarker can replace a clinical endpoint it is called a surrogate endpoint.
In medicine, a biomarker is an indicator of a particular disease state or a particular state of an organism.
A substance sometimes found in the blood, other body fluids, or tissues that can be used to assess the presence of cancer.
A substance sometimes found in the blood, other body fluids, or tissues. A high level of biomarker may mean that a certain type of cancer is in the body. Examples of biomarkers include CA 125 (ovarian cancer), CA 15-3 (breast cancer), CEA (ovarian, lung, breast, pancreas, and gastrointestinal tract cancers), and PSA (prostate cancer). Also called tumor marker.
A biomarker can be understood as a molecule that is present (or absent) from a particular cellular type. This facilitates the characterization of a cell type, their identification, and eventually their isolation. Cell sorting techniques are based on cellular biomarkers (for example, Fluorescent-activated cell sorting).
certain proteins that, when present, determines the type of cell.