This gene is involved in DNA repair and in the maintenance of DNA integrity.
I-SceI-based assays to examine distinct repair outcomes of mammalian chromosomal double strand breaks.
TREX2 exonuclease defective cells exhibit double-strand breaks and chromosomal fragments but not Robertsonian translocations.
Cisplatin depletes TREX2 and causes Robertsonian translocations as seen in TREX2 knockout cells.
Sequence variants in the 3'-->5' deoxyribonuclease TREX2: identification in a genetic screen and effects on catalysis by the recombinant proteins.
Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteins.
Structure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genes.
Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases.