Setd1b polyclonal antibody | 6843 | BioVision, Inc.
Polyclonal Antibody to detect Setd1b in mouse samples.
Western blot: NIH3T3 and embryonic stem cells, ELISA: Peptides.
ELISA: 1:100 – 1:500, Western Blot: 1:500.
SETD1B (UniProt/Swiss-Prot entry Q9UPS6) is a component of the SET1 histone methyltransferase (HMT) complex. This complex specifically methylates lysine 4 of histone H3, but only if the neighboring lysine 9 residue is not yet methylated. Methylation of H3K4 represents a specific tag for epigenetic transcriptional activation. SETD1B shows a non-overlapping localization with SETD1A, suggesting that both proteins play a specific role in the epigenetic control of chromatin structure and gene expression.