The cells expressing an ATR-activation domain mutant of TopBP1 show increased initiation of DNA replication in the S phase by losing local dormant origin suppression.
Title: The ATR-Activation Domain of TopBP1 Is Required for the Suppression of Origin Firing during the S Phase.
these data uncover two distinct mechanisms by which mutp53 enhances DNA replication: (i) Both contact and conformational mutp53s can bind TopBP1 and attenuate the checkpoint response to replication stress, and (ii) during normal growth, contact (but not conformational) mutp53s can override the Cdk2 requirement to promote replication by facilitating the TopBP1/Treslin interaction.
Title: Mutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin.
The rs115160714 TopBP1 may be a genetic marker of etiology and progression in laryngeal cancer.
Title: The c.*229C &gt; T gene polymorphism in 3'UTR region of the topoisomerase IIβ binding protein 1 gene and LOH in BRCA1/2 regions and their effect on the risk and progression of human laryngeal carcinoma.
The innate immune regulator STAT-5 is shown to regulate transcription of the ATR binding factor TopBP1, and this is critical for the induction of the ATR pathway in human papillomavirus-infected keratinocytes.
Title: STAT-5 Regulates Transcription of the Topoisomerase IIβ-Binding Protein 1 (TopBP1) Gene To Activate the ATR Pathway and Promote Human Papillomavirus Replication.
TOPBP1 physically binds PLK1 and promotes PLK1 kinase-mediated phosphorylation of RAD51 at serine 14, a modification required for RAD51 recruitment to chromatin.
Title: TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity.
Functional analyses indicat that the expression TopBP1 and Claspin positively affects the survival of brain cancer cells after exposure to radiation.
Title: TopBP1 and Claspin contribute to the radioresistance of lung cancer brain metastases.
TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation.Crucial residues mediating TopBP1-MDC1 interactions identified.
Title: TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation.
TopBP1 maintains genome integrity in mitosis by controlling chromatin recruitment of SLX4 and by facilitating unscheduled DNA synthesis.
Title: TopBP1 is required at mitosis to reduce transmission of DNA damage to G1 daughter cells.
Findings demonstrate that TopBP1 and ATR are able to inhibit the synthesis of rRNA and to activate nucleolar stress pathway.
Title: High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation.
Title: TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution.
Homologs of the TOPBP1 gene: The TOPBP1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.