TRANSPORTER CERTIFIED™ is an industry standard that ensures hepatocytes have physiologic transporter function, metabolic competence and appropriate regulatory pathway functionality, under culture conditions we have defined. In sandwich culture, the intracellular concentrations (ICC) in TRANSPORTER CERTIFIED hepatocytes reflect physiologic conditions because the hepatocytes express functioning uptake and efflux transporters and develop bile pockets similar to bile canaliculi.
Data from our assessment of a new lot is compared to our extensive historical database of hepatocyte lots.