What is Howel-Jolly bodies may be seen after ? and explain in detail?
Ans:B.) Splenectomy Howell-Jolly bodies They are histopathological findings of basophilic nuclear remnants (clusters of DNA) in circulating erythrocytes. Howell-Jolly bodies are seen with markedly decreased splenic function. Common causes include asplenia (post-splenectomy)or congenital absence of spleen. Other causes are radiation therapy involving the spleen, such as that used to treat Hodgkin lymphoma. Howell-Jolly bodies are also seen in: amyloidosis, severe hemolytic anemia, megaloblastic anemia, hereditary spherocytosis, heterotaxy with asplenia and myelodysplastic syndrome.