What is Amiloride can cause hyperkalemia due to its action on : and explain in detail?
Amiloride and triamterene are K+ sparing diuretics that act by inhibiting epithelial Na+ channels.
In the distal tubules and collecting ducts, three separate channels are present (one for Na+, K+ and H+ each). Aldosterone acts on DCT and CD to cause reabsorption of Na+. This generates a lumen negative potential difference across the membrane of this part of the nephron. To maintain the electric neutrality, K+ and H+ are secreted in the lumen.