What is The pathogonomic finding in pseudogout is ? and explain in detail?
Ans. is 'a' i.e., CPPD crystals under microscope Pseudogout It is one of the forms of "Calcium pyrophosphate dihydrate" (CPPD) ahropathy Pseudogout commonly involves the larger joints. Knee joint is most commonly involved; other sites are wrist, elbow, shoulder, ankle. Involvement of small joints is uncommon. Age group is > 60 yrs. In CPPD ahropathy, CPPD deposition occurs in aicular tissues. It can present in any of the following three forms? Asympatomatic chondrocalcinosis Acute synovitis - Pseudogout Chronic pyrophosphate ahropathy The radiologic hallmark of CPPD is "chondrocalcinosis". Chondrocalcinosis is seen as punctate and/or linear radiodense deposits in fibrocailaginous joint menisci or aicular hyaline cailage. Definitive diagnosis is made by synol fluid polarised light microscopy which shows weakly positive, birefkingent, rhomboid crystals of CPPD. In acute synovitis form, leucocytosis (thousands to 1 lac cells/ 1) is seen in synol fluid examination. It may be associated with ceain underlying disease such as - Primary hyperparathyroidism Hemochromatosis Hypomagnesemia Hypophosphatasia Hypothyroidism