What is Treatment of choice for prinzmetal's angina and explain in detail?
Ans. is 'a' i.e., Nitroglycerine Treatment of variant angina Prinzmetal's variant angina is due to spasm of coronary vessels. The drugs which dilate the coronary vessels, are the main treatment of Prinzmental's angina. Drugs are : Nitrates Calcium channel blockers (verapamil, diltiazem) Nitroglycerin is considered the drug of choice for the patient with variant angina. Prazosin a selective a-blocker may also be used because it prevents a mediated vasospasm. ii-blocker's are contraindicated because they cause constriction of coronary aery due to unopposed a mediated vasoconstriction. Prevention of variant angina In contrast Nitrates are not used for the prevention of variant angina because of delevelopment of tolerance. CCBs are the DOC for prevention.