What is "Anhedonia" seen in schizophrenia is linked to which of the following neurotransmitter abnormality? and explain in detail?
Anhedonia refers to the reduced ability to experience pleasure.In animal models severe stress causes nucleus accumbens dopamine neurons to become insensitive to CRF (Coicotropin-Releasing Factor), resulting in reduced dopamine release and increased anhedonia.(Ref: Kaplan and Sadock&;s synopsis of psychiatry Pg 290)