What is Which of the following antihypeensive cause sedation and explain in detail?
Refer kDT 6/e p546 The classic centrally acting antihypeensives such as clonidine, guanfacine and alpha-methyl-DOPA ( its active metabolite alpha-methyl-noradrenaline) induce peripheral sympathoinhibition and a fall in blood pressure as a result of alpha2-adrenoceptor stimulation in the brain stem. These drugs have lost much of their clinical impoance because of their unourable side-effects (sedation, dry mouth, impotence), which are also mediated by alpha2-adrenoceptors, although in other anatomical regions