What is The therapeutic efficacy of antihypertensive drugs is blunted by NSAIDs because they: and explain in detail?
Ans. (D) Decrease the synthesis of vascular prostacyclins(Ref: KDT 8th/e p215)*PGE2 and PGI2 cause renal vasodilation, natriuresis and increased water clearance due to inhibition of the action of ADH.*Loop diuretics act partly by increasing the stimulation of COX; therefore NSAIDs attenuate the diuretic action of these drugs.