What is Clomiphene citrate, apa from ovulation induction, can be tried for which of the following disorders? and explain in detail?
Clomiphene is thought to have effects on the hypothalamic axis which promotes gonadotropin release. Gonadotropin stimulates pituitary LH & FSH secretion which helps in testosterone production and hence in spermatogenesis. The drug is staed at a dose of 25mg daily dose to increase the FSH. Usually given for a period of 3 months, the spermatogenesis cycle length. This regime is an 'OFF-Label" use in practice since its not yet universally accepted. However, its a frequent therapy given prior to going in for more elaborate and expensive treatment by IVF.