What is Conversion of angiotensin-I to angiotensin-II occurs in ? and explain in detail?
Ans. is 'b' i.e., Lung Angiotensinogen (a2 - globulin) is produced in liver and is conveed to angiotensin I (A-I) with the help of renin which is secreted by juxtaglomerular cells of afferent aerioles of kidney and lacis cells (located in the junction between the afferent and efferent aerioles). Angiotensin 1 is conveed to Angiotensin II (A-II) by angiotensin conveing enzyme (ACE). Which is located primarily on the luminal surface of vascular endothelial cells, especially in lungs. Most of actions of this system are due to angiotensin II. Angiotensin II has a very sho tY2 (1 minute), it is degraded into angiotensin-III by aminopeptidase. Angiotensin-III is fuher acted upon by angiotensinases to inactive fragments.