What is Which of the following statements about tedizolid is true? and explain in detail?
Ans. B. It is active against gram positive organisms* Tedizolid Phosphate is an oxazolidinone-class antibiotic prodrug indicated in adults for the treatment of acute bacterial skin and skin structure infections (ABSSSI) caused by susceptible isolates of several Gram-positive bacteria.* Following administration oral or intravenous route, tedizolid phosphate prodrug is conveed by plasma phosphatases to its active moiety, tedizolid.* The active metabolite of tedizolid binds to the 50S bacterial ribosomal subunit, inhibiting protein synthesis and causing its bacteriostatic effects.* Tedizolid is an effective and potent alternative to linezolid for the treatment of patients with Gram-positive ABSSSI due to MRSA or MSSA.* Increased potency allows for once daily dosing with reduced total dosages, improving the side effect profile of this drug.* Of note, the minimum inhibitory concentrations of tedizolid appear to be largely unaffected by the chloramphenicol-florfenicol resistance (cfr) gene, which has been implicated in a number of published linezolid-resistant organism outbreaks.* OPTIC NEUROPATHY,PERIPHERAL NEUROPATHY ARE LESS SEEN WITH TEDIZOLID THAN OTHERS IN SAME CLASS