What is Glomerular filtration barrier does not permit and explain in detail?
Glomerular filtration barrier - it has: - Glomerular capillary - has endothelial cells which are fenestrated Basement membrane Layer of epithelial cells (podocytes) Characteristics of the filtration barrier: - Has high filtration rate. Capillary endothelium is perforated by thousands of small holes called fenestrae. The basement membrane contains negatively charged sialo proteins; they repel negatively charged plasma proteins. Glomerular capillary has epithelial cells, these cells are not continuous but have long footlike processes (podocytes). Podocytes are separated by filtration slit pores, through which the filtrate moves. The epithelial cells also have negative charge. Pores of glomerular capillary are thought to be about 4 - 8 mm. (40- 80 angstroms) Filtration is both size selective & charge selective.