What is Which of the following drugs can be used for secondary prevention of coronary aery disease? and explain in detail?
Ans. is'a'i.e., GemfibrozilGemfibrozilThis fibric acid derivative effectively lowers plasma TG level by enhancing breakdown and suppressing hepatic synthesis of TGs.Besides high efficacy in type III hyperlipoproteinemia, gemfibrozil has shown action in subjects with raised blood CH in addition.In the 'Helsinki Hea Study' men without known CAD treated with gemfibrozil had a 34% reduction in fatal and nonfatal MI, though overall moality was not affected.That these benefits extend to secondary prevention of coronary events in men with existing CAD and low HDL CH, has been demonstrated in another trial.