What is What is true about thalidomide and explain in detail?
Thalidomide It is reintroduced as immunomodulator. uses:- 1)Angiogenesis inhibitor antitumour activity 2)anxiolytic 3)antiemetic 4)adjuvant analgesic/antipyretic propey 5 )improves cancer associated cachexia 6) used in erythema nodosum leprosum 7) multiple myeloma Mech of action:- It acts by suppressing TNFa and by modulating IL-2. contraindication:- In Pregnancy due to phocomelia(seal like limbs). Ref:- kd tripathi; pg num:-877