What is In PAN, cysts are seen in all except - and explain in detail?
Ans. is 'a' i.e., Lung Distinguishing features of PANo The most distinguishing feature of PAN is lack of pulmonary involvement which distinguishes PAN from, wegner's granulomatosis, microscopic polyangitis and churg strauss syndrome. Which have vasculitis in combination with pulmonary symptoms.o There is no involvement of small blood vessels, ie. arterioles, venules and capillaries this leads to : -Renal involvement without glomerulonephritis.Skin involvement without purpura.Polyarteritis nodosa (PAN)o Polyarteritis nodosa or classical polyarteritis nodosa is systemic necrotizing vasculitis of medium sized muscular arteries, but does not involve small vessels i.e., arterioles, venules or capillaries,o It typical ly involves the vessels of many visceral organs but sparing the pulmonary circulation.Clinical presentationo Symptoms results from ischemic damage to affected organs.Non-specific constitutional symptomso As with other vasculitis, these are the most common manifestations,o Fatigue, malaise, fever. Anorexia, weight loss.Musculoskeletalo These are the most common vasculitis related symptoms,o Arthritis, Arthralgia, myalgia.Renalo Hypertension, Renal failureo Renal arteiy involvement is the major cause of death.Peripheral nervous systemo Peripheral neuropathy and mononeuritis multiplex.GITo Abdominal pain, nausea, vomiting,o Bleeding, Bowel infarction and perforation,o Hepatic infarction and cholecystitis,o Pancreatic infarctionSkino Rash, livedo reticularis, nodules, ulcerations, Raynaud's phenomenon.Cardiaco CHF, pericarditis, MICNSo Cerebrovascular accident, seizures, altered mental status.Genito-urinaryo Testicular, ovarian or epididymal pain.