What is An example for tumor suppressor gene is and explain in detail?
Selected Tumor Suppressor GenesInhibitors of Mitogenic Signaling Pathways1. APC2. NF13. NF24. PTCH5. PTEN6. SMAD2, SMAD4Inhibitors of Cell Cycle Progression1. RB2. CDKN2AInhibitors of "pro-growth" Programs of Metabolism and Angiogenesis1. VHL2. STK113. SDHB, SDHDInhibitors of Invasion and MetastasisCDH1Enablers of Genomic StabilityTP53DNA Repair Factors1. BRCA1, BRCA22. MSH2, MLH1, MSH6Unknown Mechanisms1. WT12. MEN1Reference: Robbins and Cotran Pathologic Basis of Disease; 9th edition; Chapter 7; Neoplasia