What is Upper segment : lower segment ratio in Growth hormone deficiency: and explain in detail?
- Growth hormone deficiency is a cause of propoionate sho stature - so upper segment : lower segment ratio remains normal or unchanged. CLINICAL FEATURES OF GH DEFICIENCY: Delayed bone age, dentition, pubey, milestones Hypoglycemia Frontal bossing High pitched voice Sho stature DIAGNOSIS: 1. GH stimulation test : Done using insulin/ arginine/ clonidine/ glucagon Peak GH level <10 ng/ml - GH deficiency 2. Bone age < Chronological age Treatment:Recombinant GH injections subcutaneously