What is The drug of choice for the treatment of Thyrotoxicosis during pregnancy is ? and explain in detail?
Ans. is 'c' i.e., Propylthiouracil o Both carbimazole and propylthiourcil can be used during pregnancy, but propyl-thiouracil is the drug of choice because its greater protein binding allows low doses of propylthioracil to be transferred across the placenta and therefore less chance of hypothyroidism. o Historically, prophylthiouracil has been preferred over methimazole because transplacental passage was thought to be lower; However, according to recent studies, both propylthiouracil and methimazole cross the placenta equally and either may be used safety in the pregnant patient. Note : However, if you will have to choose one option, prophylthiouracil is still the best because all other books still mention prophylthiouracil as the DOC in pregnancy.