What is Which of the following is not a second generation antihistamines and explain in detail?
Antihistamines are classified as first generation and second generation compounds on the basis of CNS penetration and anticholinergic propeies. first generation antihistamines can penetrate blood brain barrier and possess additional anticholinergic propeies which are lacking in second generation drugs. cyclizine is a first generation Where are citirizen ,loratidine and fexofenadine are second generation drugs Refer Goodman and Gilman 12/e p92