What is Drug of choice in phenothiazine-induced Dystonia is: and explain in detail?
Answer is D (Benztropine): Central anticholinergics (eg. Benztropine) are the only drugs effective in phenothiazine /drug induced extrapyramidal symptoms' Central anticholinergics include Triherphenidyl : Most commonly used drug (Benzhexol) Procyclidine Biperidin Benztropine. All antipsychotics have potent dopamine blocking action. Dopaminergic blockage in basal ganglia results in deficiency of dopamine, which controls muscle tone and coordinates movements. This is turn shift the balance between the inhibitory dopaminergic system and excitatory cholinergic system, towards excitatory levels and results in dystonias. Balance can thus be restored by suppression of the unopposed excitatory cholinergic system (Administration of central anticholinergics).