What is Pathergy test is positive in? and explain in detail?
ANSWER: (B) Behcet's diseaseREF: Harrison 17th ed Table 320-1"Pathergy is a cutaneous phenomenon seen with both Behcet's disease and pyoderma gangrenosum"In this condition a minor trauma such as a bump or bruise leads to the development of skin lesions or ulcers that may be resistant to healing. Pathergy can also lead to ulcerations at the site of surgical Incisions.It is also important to note that, while a positive pathergy reaction helps to confirm a specific Behcet's disease diagnosis, a negative reaction does not invalidate a BD diagnosis, because the disease process has to be active at the time of the skin prick test to produce a pathergy reaction.Diagnostic Criteria of Behcet's DiseaseRecurrent oral ulceration plus two of the following:Recur rent genital ulcerationEye lesionsSkin lesionsPathergy test