What is Therapeutic drug monitoring is used in ? and explain in detail?
Ans. is 'd' i.e., Digoxin Therapeutic drug monitoring is paicularly useful in following situations ? 1. Drugs with low safety margin ? Digoxin Aminoglycoside antibiotics Anticonvulsants Lithium Antiarrythmics Tricyclic antidepressants Theophylline 2. If individual variations are large - Antidepressants, Lithium 3. Potentially toxic drugs used in presence of renal failure - Aminoglycoside antibiotic, vancomycin, cyclosporine 4. In case of poisoning 5. In case of failure of response without any apparent reason - Antimicrobials 6. To check patient compliance -. Psycho-pharmacological agents. Drugs whose response is easily measurable eg. hypoglycaemics (metformin), antihypeensive, diuretics, oral anticoagulants and general anaesthetics, monitoring of plasma conc. is of no value.