What is Furosemide mechanism of action in LVF is: September 2010 and explain in detail?
Ans. A: Inhibitor of Na-K-Cl ion sympo Like other loop diuretics, furosemide acts by inhibiting the Na-K-2C1 sympoer in the thick ascending limb of the loop of Henle. The action on the distal tubules is independent of any inhibitory effect on carbonic anhydrase or aldosterone; it also abolishes the coicomedullary osmotic gradient and blocks negative as well as positive free water clearance.