Limehouse stretches from Limehouse Basin in the west to the edge of the former Chinatown in Pennyfields in the east; and from the Thames in the south to the Victory Bridge at the junction of Ben Jonson Road and Rhodeswell Road in the north.
L'area ha dato il nome al "Limehouse Reach", una porzione del Tamigi che va da Shadwell, attraverso Ratcliff e poi Limehouse a Millwall.