Louis mounted another invasion of Milan, but was defeated at the Battle of Novara, which was quickly followed by a series of Holy League victories at La Motta, Guinegate, and Flodden, in which the French, Venetian, and Scottish forces were decisively defeated.
Comunque la morte di Papa Giulio II lasciò la Lega senza una leadership, e quando il successore di Luigi, Francesco I, sconfisse gli svizzeri nella Marignano nel 1515, la Lega collassò, e nei trattati di Noyon e Brussels, abbandonarono alla Francia e a Venezia l'Italia del Nord.