In 1877 he married Adelheid von Rothschild of Naples, the daughter of Wilhelm Carl von Rothschild, with whom he had three children: James Armand Edmond, Maurice Edmond Karl and Miriam Caroline Alexandrine.
== Interessi artistici e filantropici ==Edmond de Rothschild ereditò il castello Rothschild, a Boulogne-Billancourt, e possedeva il castello Rothschild d'Armainvilliers a Gretz-Armainvilliers nel dipartimento della Senna e Marna.