In eight patients receiving 40 mg twice daily in the fasted state, steady-state AUC0-12h was 1284±227 ng⋅ h/ ml (18%) (mean ± SD [% CV]), Cmax was 536±146 ng/ ml (27%), and Cmin was 9±8 ng/ ml (89%).
In 8 pazienti trattati con 40 mg due volte al giorno a stomaco vuoto, l' AUC allo steady-state è stato 1284±227 ng⋅ h/ ml (18%) (media ± DS [% CV]), la Cmax è stata 536±146 ng/ ml (27%), la Cmin è stata 9±8 ng/ ml (89%).