<s>[INST] Best way to strip punctuation from a string in Python It seems like there should be a simpler way than:
import string
s = "string. With. Punctuation?" # Sample string 
out = s.translate(string.maketrans("",""), string.punctuation)

Is there?
 [/INST] From an efficiency perspective, you're not going to beat translate() - it's performing raw string operations in C with a lookup table - there's not much that will beat that but writing your own C code.
If speed isn't a worry, another option though is:
exclude = set(string.punctuation)
s = ''.join(ch for ch in s if ch not in exclude)

This is faster than s.replace with each char, but won't perform as well as non-pure python approaches such as regexes or string.translate, as you can see from the below timings.  For this type of problem, doing it at as low a level as possible pays off.
Timing code:
import re, string, timeit

s = "string. With. Punctuation"
exclude = set(string.punctuation)
table = string.maketrans("","")
regex = re.compile('[%s]' % re.escape(string.punctuation))

def test_set(s):
    return ''.join(ch for ch in s if ch not in exclude)

def test_re(s):  # From Vinko's solution, with fix.
    return regex.sub('', s)

def test_trans(s):
    return s.translate(table, string.punctuation)

def test_repl(s):  # From S.Lott's solution
    for c in string.punctuation:
        s=s.replace(c,"")
    return s

print "sets      :",timeit.Timer('f(s)', 'from __main__ import s,test_set as f').timeit(1000000)
print "regex     :",timeit.Timer('f(s)', 'from __main__ import s,test_re as f').timeit(1000000)
print "translate :",timeit.Timer('f(s)', 'from __main__ import s,test_trans as f').timeit(1000000)
print "replace   :",timeit.Timer('f(s)', 'from __main__ import s,test_repl as f').timeit(1000000)

This gives the following results:
sets      : 19.8566138744
regex     : 6.86155414581
translate : 2.12455511093
replace   : 28.4436721802

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