(CNN) -- It was deja vu for the Williams sisters at the French Open -- but not in a good way. 

A mouthwatering third-round clash between seven-time grand slam champion Venus and 17-time major winner Serena was ruled out when the former lost to unseeded Slovakian Anna Schmiedlova 2-6 6-3 6-4 in early play in Paris on Wednesday. 

Then hours later, Serena -- also the defending champion and world No. 1 -- fell to Spain's Garbine Muguruza 6-2 6-2, her worst ever grand slam performance. 

In 2008, the siblings were also defeated on the same day at Roland Garros, their least productive major. The last time it happened was at Wimbledon in 2011. 

An 18th grand slam singles crown for Serena would have tied her with legends Chris Evert and Martina Navratilova but the younger of the tennis playing sisters has now been upset in consecutive majors. 

Venus has been hindered by debilitating autoimmune disease Sjogren's Syndrome in recent years though she looked solid in her first round match against the promising Swiss, Belinda Bencic. 

The siblings join other big names who've already been upset at the tournament, including Australian Open champions Stan Wawrinka and Li Na, as well as Kei Nishikori and Caroline Wozniacki. 

Defeat for Serena meant it was the first time in the Open era that the top two women's seeds had fallen before the third round. 

"I don't think anything worked for me today," a dejected Serena told reporters at her post-match press conference. 

"It was one of those days. You can't be on every day, and, gosh, I hate to be off during a grand slam but it happens. It's not the end of the world.  QUESTIONS:

Q1:
1. Who is a seven time winner?
2. Who's had seven victories?
3. Who has come out on top seven times?
Q2:
1. Does Venus Williams have a disease?
2. Is Venus Williams ill?
3. Is the health of Venus Williams compromised?
Q3:
1. What disease does Venus Williams have?
2. What disorder does Venus Williams suffer from?
3. What syndrome is Venus Williams sick with?
Q4:
1. Is Sjogren's Syndrome contagious?
2. Does Sjogren's Syndrome pass from person to person?
3. Can you infect another person with Sjogren's Syndrome if you have it?
Q5:
1. What did Venus Williams win seven times?
2. What was Venus Williams a seven time champion at?
3. What victory was claimed by Venus Williams seven times?
Q6:
1. Who was having deja-vu?
2. Who felt like they were living the same experience all over again?
3. Who felt the sensation of deja-vu?
Q7:
1. Where were the Williams sisters having deja vu?
2. In what location did the Williams sisters experience deja vu?
3. Where did the Williams sisters feel like they were reexperiencing a situation?
Q8:
1. How many Grand slams has Serena Williams won?
2. What's the number of Grand Slams that Serena Williams has under her belt?
3. What's the number of grand slam championships that have gone to Serena Williams?
Q9:
1. What occured in 2008?
2. What event took place in 2008?
3. What happened to the Williams sisters in 2008?
Q10:
1. What occured in 2011?
2. What event took place in 2011?
3. What happened to the Williams sisters in 2011?
Q11:
1. Is there anyone who has ever won 18 Grand Slams?
2. Has someone ever won 18 Grand Slams?
3. Are there any players with 18 grand slams under their belt?
Q12:
1. Who has won 18 grand slams?
2. Who has got 18 grand slams under their belt?
3. What players have had 18 grand slam crowns?
