In her travels she covered the North American continent from Alaska to Panama, both coasts of South America and the interior of the southern portion, eastern, western, and southern Asia and northern Africa; and she made numerous visits to Europe. Her activity as an Alpinist began with eight ascents of first-class peaks in the Alps in 1909-10. Starting with the opportunity to climb the Matterhorn, Keen traveled to Zermatt in the summer of 1909, where she climbed the Zinal Rothorn, the Monte Rosa, the Weisshorn, and the Matterhorn.