The Mātukituki River is found in the Southern Alps of New Zealand's South Island. Both the West Branch and the East Branch originate from the Main Divide mountain ranges near Mount Aspiring and their largely glacier-fed waters flow for approximately each before joining near Camerons Flat. After this confluence, the Mātukituki River leaves the boundaries of Mount Aspiring National Park and continues for another until it drains into Lake Wānaka at the lake's southwestern edge.