Gastrotheca bufona (common name: Antioquia marsupial frog) is a species of frog in the family Hemiphractidae. It is endemic to Colombia and known from the Cordillera Central and Cordillera Occidental in Antioquia and Caldas Departments, at elevations of asl. The specific name bufona is derived from Spanish bufón, meaning a jester or clown, and refers to the frog's gaudy appearance.