Oregon Route 22 is an Oregon state highway that runs between the Oregon Coast community of Hebo, to an interchange with U.S. Route 20 near Santiam Pass in the Cascade Mountains. OR 22 traverses several highways of the Oregon state highway system: the Three Rivers Highway No. 32, part of the Salmon River Highway No. 39, the Willamina-Salem Highway No. 30, part of the Salem Highway No. 72, and the North Santiam Highway No. 162.