Formed by the confluence of the East and West Branches of the river, the Ovens River rises in the Victorian Alps, at the settlement of Harrietville, sourced by runoff from high slopes located within the Alpine National Park and the Mount Buffalo National Park. The river flows generally north by west and is joined by eighteen tributaries including Morses Creek at Bright, the Buckland River at Porepunkah, the Buffalo River and then the King River at Wangaratta. The river descends over its course. The Great Alpine Road follows much of the course of the river in its upper reaches.