The line begins in Disentis in the canton of Graubünden, where there is a connection to the Rhätische Bahn (RhB). It then runs over the Oberalp Pass to Andermatt in the canton of Uri. Through the Furka Base Tunnel it reaches the Goms District area and Brig in the canton of Valais. In Brig, it connects to the BVZ Zermattbahn since 1930.