Kasese is at the western end of the Uganda Railway to Kampala and Tororo and is home to Kasese Airport. The city is near the Rwenzori Mountains and Queen Elizabeth National Park. Kasese is approximately , by road, west of Kampala, Uganda's capital and largest city. This is about , by road, north-east of Mpondwe, the border town at the international border between Uganda and the Democratic Republic of the Congo (DRC). The coordinates of Kasese are 0°11'12.0N, 30°05'17.0E (Latitude:0.186667; Longitude:30.088050).