US 221, US 460, and US 220 Alternate head east as a six-lane divided highway that passes under Norfolk Southern Railway's Roanoke District and intersects SR 115 (Hollins Road). The road reduces to four lanes at Tinker Creek and becomes named Challenger Avenue on re-entering Roanoke County. US 220 Alternate turns north onto Cloverdale Road in the community of Bonsack just west of where US 221 and US 460 enter Botetourt County. The U.S. Highways continue as Blue Ridge Boulevard and meet the Blue Ridge Parkway at an interchange south of the community of Blue Ridge, where the highways parallel Norfolk Southern's Blue Ridge rail line through Buford's Gap to enter Bedford County. US 221 and US 460 continue east as the Lynchburg Salem Turnpike through the village of Thaxton to the town of Bedford.