The Großes Wiesbachhorn is almost entirely surrounded by glaciers. To the north is the Wielingerkees, to the northeast the Sandbodenkees flows eastwards and down into the Sandboden and further into the Fuscher Ache. To the south lies the Teufelsmühlkees und im Westen das Kaindlkees. An important neighbouring mountain to the north, separated by the 3,211-metre-high wind gap of the Sandbodenscharte, is the Kleines Wiesbachhorn with a height of 3,286 metres. To the southwest, on the other side of the 3,265-metre-high Wielingerscharte, between the Kaindlkees and Teufelsmühlkees glaciers, lies the two Bratschenköpfe peaks (3,413 and 3,401 metres high). To the west the terrain falls away to the Mooserboden Reservoir, to the east into the Fuscher Tal. The nearest important settlement is Fusch an der Großglocknerstraße, about 10 kilometres away to the north as the crow flies.