Twight made several notable ascents in the Alaska Range. In 1994, he and Scott Backes climbed Deprivation on Mount Hunter in 72 hours roundtrip, which halved the previous fastest ascent of the North Buttress. The 39 hours non-stop ascent is considered a landmark moment in the single-push climbing movement. Twight's participation in this style of climbing culminated with the 60-hour ascent of the Slovak Direct on the south face of Denali in June 2000 with Backes and Steve House. During his visits to the Alaska Range, Twight participated in a variety of high-profile rescues. Twight was nominated for the Piolet d'Or twice during his career, in 1993 for Beyond Good and Evil and 1995 for Deprivation.