Most of the peaks in East Nyenchen Tanglha, sometimes called the Alps of Tibet, are unclimbed. Sepu Kangri itself was attempted twice by Chris Bonington and Charles Clarke in 1997 and 1998, about which experience Bonington and Clarke wrote the book Tibet's Secret Mountain: The Triumph of Sepu Kangri (). The summit was finally reached on 2 October 2002 by Mark Newcomb and Carlos Buhler.