Cerro Blanco is located south of the southern end of the Filo Colorado/Los Colorados mountain range and at eastern end of the Cordillera de San Buenaventura. The Cordillera de San Buenaventura marks the southern margin of the Puna and extends west-southwestwards from Cerro Blanco to the volcanoes San Francisco and Falso Azufre and the Paso de San Francisco. It marks the boundary between the steep subduction to the north from the shallower subduction to the south.