Oreophrynella weiassipuensis is a species of toads in the family Bufonidae. It is only known from Wei-Assipu-tepui, a tepui on the border between Brazil and Guyana. The holotype was collected in 2000 by a speleological expedition to Wei-Assipu-tepui. No other specimens are known. It is possible that it is present in other localities, but most species of Oreophrynella are endemic to a single mountain.