The municipal area stretches along the Antholz valley, a northern side valley of the larger Puster Valley. In the northeast, the Staller Saddle mountain pass, at a height of leads into the Defereggen Valley in East Tyrol, Austria. The Antholz valley is confined by the mountains of the Rieserferner Group in the north and the Villgraten Mountains in the east, both part of the High Tauern range in the Central Eastern Alps. Notable peaks include the Hochgall, at , and the Wildgall (Collaspro), at , as well as the Ohrenspitzen massif, at , in the northeast. Large parts of the northern and western mountain ranges belong to the Rieserferner-Ahrn Nature Park established in 1988. The Antholzer Bach stream runs through the valley from Antholzer See (Lago di Anterselva) down to its confluence with the Rienz (Rienza) river at Olang.