From its confluence with Los Alamos Canyon Creek, San Mateo Creek turns its course southwest down San Mateo Canyon, cutting a deep arid canyon surrounded by slopes dissected by many side canyons between the Santa Ana and Santa Margarita Mountains. At river mile (RM) 18 or river kilometer (RK) 28.9, Tenaja Canyon Creek, which flows generally northwest, comes in from the left. Shortly after, at RM 17.5 (RK 28.1) Bluewater Canyon Creek descends from Sitton Peak, to merge with San Mateo Canyon from the right. Nickel Canyon Creek also comes in from the right, descending from the Verdugo Potrero shortly afterward, joining San Mateo Creek just north of the Riverside - San Diego County line.