Most trekkers cross the pass from east to west (Manang to Muktinath), which is the easiest and safest direction. It is not possible to cross Thorong La from Manang to Muktinath in one day. Trekkers usually spend the first night in Yak Kharka and second night in Thorong Phedi — which is situated at , or at Thorong High Camp — which is situated at before attempting to go over Thorong La Pass. Choosing this option decreases the elevation gain and loss for that day's hike, as well as decreasing the distance. The staff of the Himalayan Rescue Association post in Manang recommend that trekkers spend five nights between their arrival in Manang and the crossing to Muktinath. The additional time spent in Manang allows trekkers to acclimatize sufficiently to minimize the risk of acute mountain sickness (AMS). The Himalayan Rescue Association operates a medical clinic at Manang, and a small satellite medical clinic at Thorong Phedi.