Kyriaki () is a village in the central part of the Evros regional unit in Greece, in the municipal unit of Orfeas of the municipality Soufli. With 100 inhabitants (2011 census) it is the least populated community in the municipal unit. Kyriaki is in a valley in the wooded Eastern Rhodope Mountains, 15 km southeast of the Bulgarian-Greek border. It is situated between the villages Mikro Dereio and Protokklisi.