George Henry Hamilton Tate led a major expedition of the American Museum of Natural History to Cerro Duida in 1928-1929. Named the Tyler-Duida Expedition, it was the first to reach the mountain's summit plateau and the first to climb a tepui of the Venezuelan Amazon. Mount Duida frog was first collected during the expedition and is still not known from anywhere else, although it was formally described only 40 years later. Although primarily a zoological expedition, much plant material was collected. These herbarium collections were studied extensively by Henry Gleason, who formally described many of the mountain's plant species in a series of papers published in 1931. This was followed by a number of important botanical explorations of Cerro Duida, first by Julian A. Steyermark in 1944 and later by Bassett Maguire in 1949 and 1950.