In Stanley, SH-21 terminates at at the junction with SH-75, the Sawtooth Scenic Byway from Galena Summit and Ketchum to the south, originating in Shoshone. North of the intersection in Stanley, Highway 75 becomes the Salmon River Scenic Byway, and continues due north for a mile, then veers east with the twisty main Salmon River as it descends to Clayton, then north towards Challis, where the route terminates and rejoins US-93 just south of the city limits.