In the ninth stage of the Tour de France, Voeckler led a breakaway, survived a collision caused by a media support car that injured two other riders, and crossed the line second, taking the overall time lead and therefore wearing the yellow jersey (). He held on to the yellow jersey daily from the beginning of Stage 10 onwards, carrying it through all the Pyrenean mountain stages and into the Alps, but he was unable to retain it at the end of Stage 19, the queen stage finishing at Alpe d'Huez. Voeckler finished in fourth place in the final general classification, 3 minutes and 20 seconds behind the winner, Cadel Evans. It was Voeckler's highest final general classification in the Tour, and the highest placing of any Frenchman in the Tour, at the time, since Christophe Moreau's fourth-place overall finish in 2000.