The park began to be laid out in the 1960s, with the declaration of the Jaguani and Cupeyal del Norte nature reserves. This continued into the 1980s with the proposal of the Ojito del Agua Refuge, associated with the last sighting of the royal woodpecker, a last remnant of this species which was already extinct in its other habitats in the United States and Mexico. In 1996 these protected areas were united to form a national park that was named after Alexander von Humboldt. Being one of the most important biosphere reserves in the Caribbean basin, the national park, along with Cuchillas del Toa was declared a UNESCO World Natural Heritage Site in 2001.