Laetiporus sulphureus is widely distributed across Europe and North America, although its range may be restricted to areas east of the Rockies. It grows on dead or mature hardwoods and has been reported from a very wide variety of host trees, such as Quercus, Prunus, Pyrus, Populus, Salix, Robinia, and Fagus, occasionally also from conifers, from August to October or later, sometimes as early as June. In the Mediterranean region, this species is usually found on Ceratonia and Eucalyptus. It can usually be found growing in clusters.