The Rubeho Mountains are a dissected plateau, covering an area of 4636 km². The highest peaks in the range are Mangalisa (2,286 m), Mafwemiro (2,152 m) and Ledengombe (1,941 m). On the south, the steep-sided valley of the Great Ruaha River separates the Rubheho Mountains from the Udzungwa Mountains. On the southeast a narrow gap separates the Rubeho Mountains from Uvidunda Mountains. The Pala Mountains are close to the east, and the Mkata Plain beyond them. The Mkondoa River separates the Rubeho Mountains from the Ukaguru Mountains on the north and northeast. The Wota Mountains, a western outlier of the Rubeho mountains, and East African Plateau lie to the west.