The mesa is traversed by the Grand Mesa Scenic and Historic Byway, which includes SH 65, between the town of Mesa on the north and the town of Cedaredge on the south. The route over the mesa provides a dramatic contrast in landscape, climate and vegetation. On the north side, the road climbs the steep terrain near the Powderhorn Resort ski area. The forested top of the mesa remains snowbound much later in the spring than the surrounding valleys, and is a popular location for cross-country skiing and snowmobiling.