The Biobío River originates at the east shore of Galletué Lake. The river flows east for a few kilometers to the point where it receives the waters of the near Icalma Lake, through a short stream. It then turns its course northwestward, meandering through a broad Andean valley and merging with some minor tributaries, as are the Lonquimay and the Rahue. The Lonquimay is fed by some glaciers of Sierra Nevada and passes close to the town of the same name. Just downstream from the confluence with the Rahue, the upper course of the river-locally known as Alto Bío Bío-begins to run rapidly through a narrow valley surrounded by mountains, the path becoming increasingly sloped. Then the river, along the lower course of its tributaries in this area, is impounded by Ralco Dam. Below the dam, the river skirts a southwestern spur of Callaqui volcano before falling into Pangue Reservoir.