Matrei in Osttirol is a market town in the Lienz District in the Austrian state of Tyrol (East Tyrol). It is situated about north of Lienz within the Hohe Tauern mountain range of the Central Eastern Alps. Its municipal area comprises parts of the Granatspitze Group and the Venediger Group, with the Großvenediger peak () as its highest point. The population largely depends on tourism, seasonal agriculture and forestry.