Before the Huaynaputina eruption in 1591-1596, severe droughts in Anatolia caused harvest failures. The extremely cold winters that followed, associated with Huaynaputina's eruption and an eruption of Nevado del Ruiz in 1595, caused epizootics that killed large amounts of livestock in Anatolia, Crimea and the Balkans. This weakened the Ottoman Empire just as it was conducting the Long Turkish War and appears to have contributed to the onset of the Celali rebellions in Anatolia.