Located within three different U.S. National Forests, the Coconino, Kaibab, and Prescott National Forests, Sycamore Canyon is home to a variety of wildlife including black bear, deer, and mountain lion. Unlike the nearby and more heavily visited Oak Creek Canyon, much of Sycamore Canyon is protected by the Sycamore Canyon Wilderness, located at , and therefore roads and developed campgrounds are nonexistent. Hiking and horseback riding are the only ways to visit the canyon. The most popular access is via the Parsons Spring trail, upriver from Tuzigoot National Monument. A high clearance vehicle is helpful to reach the trailhead.