The Khao Ang Rue Nai Wildlife Sanctuary () is a protected area at the western extremities of the Cardamom Mountains in Chachoengsao Province, Thailand. Founded in 1977, it is an IUCN Category IV wildlife sanctuary, measuring over 1,000 km2 (67,400 rai; 10,784 ha) in area. South-east of, and connected with, the wildlife sanctuary is the Khao Sip Ha Chan National Park. South-west of the protection is the Khao Chamao-Khao Wong National Park.