After the confluence, the Isluga River proceeds in southeast-eastward direction save for a brief turn northeast, past the towns of Chaguane and Arabilla; between the two the Quebrada Taipicollo joins from the northwest. After Arabilla it turns more eastward and receives waters from the Laguna Arabilla farther south; the Isluga River here passes through wetland territory. It flows past the towns of Chapicollo, Enquelca and Coraguane before turning sharply to the south. After this turn the river continues first southeast-east, then due east between Cachaguano and Isluga where it has a slight northeasterly tilt, and finally southeastward towards Sitani and Cotasaya. The penultimate part of the river runs irregularly eastward towards Colchani and Pisigua. After a total course of before ending into the Laguna Mucalliri, which is part of a system of wetlands at Salar de Coipasa. The Cariquima River ends into the same general area and is sometimes considered to be part of the Rio Isluga. From that area, the Sitani River continues into the Salar de Coipasa proper.