Cayambe was first climbed by British adventurer Edward Whymper and his two Italian guides and companions Jean-Antoine Carrel and Louis Carrel in 1880. They made first ascents of most of the volcanoes in Ecuador. Cayambe remains a favorite of mountaineers today. The main route runs through a much-fissured terrain of moderate inclination, and only in its final part does the slope increase to 45°. There is a formidable bergschrund to cross at about . On the final stages, there are many cracks and seracs to be overcome, and there are extensive views from the summit.