The Großer Möseler is part of the Zillertal main crest, a dominant mountain chain of peaks over 3,000 metres high. Its neighbouring summits are: the subpeak of Möselekopf (3,390 m) to the south and separated by the Westliche Möselescharte notch; the Breitnock (Dosso Largo, 3,215 m) further along the Southwest Arête and separated by Nöfes Saddle a crossing at 3,029 metres; the 3,188-metre-high Furtschaglspitze on the North Arête; and the 3,304-metre-high Roßruggspitze and the Turnerkamp (Cima di Campo, 3,418 m) to the east, separated by the 3,240-metre-high Östliche Möselescharte (Eastern Mösele Notch). The Möseler is surrounded by the glaciated areas of the Schlegeiskees and Furtschaglkees to the west, the Waxeckkees to the north and the West Nevesferner (Westlicher Nevesferner) and East Nevesferner (Östlichen Nevesferner) to the south.