Großheubach lies on the right bank of the Main. The community is located on the slopes of the Mittelgebirge Spessart. The highest point in the municipal area is the 439 m-high Ospisrain. Großheubach is located on the Fränkischer Rotwein Wanderweg (Franconian Red Wine Hiking Trail). Across the Main lie the hills of the Odenwald.