The river is formed in Park County, Colorado, southwest of Denver in the South Park grassland basin by the confluence of the South Fork and Middle Fork, approximately southeast of Fairplay. Both forks rise along the eastern flank of the Mosquito Range, on the western side of South Park, which is drained by the tributaries at the headwaters of the river. From South Park, it passes through of the Platte Canyon and its lower section, Waterton Canyon. Here, it is joined by the North Fork before emerging from the foothills southwest of the Denver suburb of Littleton. At Littleton, the river is impounded to form Chatfield Reservoir, a flood-control basin for the Denver Metropolitan Area.