In 1925, Kligler was invited by Dr Judah Leon Magnes of the Hebrew University, which had just opened, to join the university. Kligler agreed, and on 1 April 1926 began work at the university. He established the Department of Hygiene and Bacteriology which he directed until his death from a heart attack in Netanya, Mandatory Palestine on 23 September 1944. He was buried in the cemetery on Mount of Olives, Jerusalem. Helen died in New York January 1979. Their only child David was born 28 March 1926. David Aaron Kligler MD, MPH was devoted to the Children's Evaluation and Rehabilitation Center at the Albert Einstein College of Medicine and was involved with the development of the Speech and Hearing Program in New York. David died on 30 December 1979, and he is buried on the Mount of Olives close to the common grave presumed to be containing his father's remains (see below under Grave).