Dead Indian Creek is a tributary of South Fork Little Butte Creek in Jackson County, in the U.S. state of Oregon. It flows generally north through the Rogue River - Siskiyou National Forest in the Cascade Range east of Medford. The creek begins at above sea level near Howard Prairie Lake and enters the South Fork at Camp Latgawa. The South Fork flows northwest to meet the North Fork near Lake Creek; combined they form Little Butte Creek, a tributary of the Rogue River.