Hasserode lies at the foot of the Harz Mountains in the valley of the River Holtemme, whose upper reaches include the water cascade of the Steinerne Renne. A state road (Landstraße) runs through the quarter to Drei Annen Hohne and Schierke in the direction of the Harz's highest mountain, the Brocken. The Harz Railway and Brocken Railway, part of the Harz Narrow Gauge Railways also run through the district which has three stations: Hochschule Harz (formerly Kirchstraße), Wernigerode-Hasserode and Steinerne Renne.