U.S. Route 160 enters Colorado near the Four Corners Monument. It goes northeast and intersects U.S. Route 491, then turns north to enter Cortez with U.S. 491. East of Cortez, a road leads south from U.S. 160 to Mesa Verde National Park. It continues east to Durango, where it intersects U.S. Route 550. After overlapping with U.S. 550 south of Durango, U.S. 160 turns east and meets U.S. Route 84 at Pagosa Springs. It then goes northeast and crosses the Continental Divide at Wolf Creek Pass.