Antofalla lies in a region of arid climate, with about precipitation, much of it in the form of snow at high elevations. Temperatures change drastically from day to night and vice versa, ranging from in the wider region; the climate has been characterized as continental. The region lies between two major climatic regimes, a northerly regime dominated by easterly moisture flows which occur during summer, and a southerly regime where westerlies transport moisture from the west mainly in winter.