The Napeequa River is a long river in the U.S. state of Washington on the east side of the Cascade Range. It rises in northwest Chelan County and flows southwest into the White River near Twin Lakes. The White River flows into Lake Wenatchee. The Napeequa River and its valley are notable for their beauty and isolation, as well as their interesting geological history. It flows through an isolated southeast-trending valley characterized by a broad meadows surrounded by rugged mountains. The Chiwawa Mountains, or Chiwawa Ridge mark the east side of the valley, separating the Napeequa and Chiwawa Rivers. To the west the White Mountains separate the Napeequa from the White River. Both are sub-ranges of the Cascade Range.