River Manafwa is a natural river found in Eastern Uganda. The river originates from Mount Elgon in east Uganda, and traverses the districts of Bududa, Manafwa, Mbale and Butaleja. It joins the Mpologoma River, which empties into Lake Kyoga. The river basin is prone to flooding, which disrupts transportation between the Bududa and Manafwa districts, and has resulted in damage to buildings and deaths.