Tuberaria guttata is widely distributed in the Mediterranean region, and has a continuous distribution along the French Atlantic coast as far as the Channel Islands. Further north, its distribution is very patchy, being confined to a few localities on the west coasts of Ireland and Wales. The best-known of these populations is on the slopes of Holyhead Mountain in Anglesey. These British populations mark the northernmost limit of the species' distribution. Tuberaria guttata was chosen by Plantlife as the county flower of Anglesey in 2002.