SC 130 travels generally in a south-north direction, beginning at a major intersection with South Carolina Highway 59 in downtown Seneca. SC 130 leaves downtown towards the east and intersects with Clemson Boulevard (US 76/US 123/SC 28). Traveling northward, the route becomes a two lane configuration and becomes more rural in character. SC 130 skirts the southern and eastern edges of Lake Keowee and provides beautiful views of the lake and the Blue Ridge Mountains. The route passes by several upscale lakefront communities and the old mill town of Newry. The route passes by the Oconee Nuclear Station prior to crossing Lake Keowee.