The first recorded ascent of Holy Cross was in 1873, by F. V. Hayden and photographer W. H. Jackson during one of Hayden's geographical surveys. However, the peak may well have been ascended previously by miners or American Indians. The first winter ascent of the peak was made in 1943 by Russel Keene and Howard Freedman of the 10th Mountain Division, then stationed at Camp Hale.