At the northwestern edge of Carinthia and bordering East Tyrol and the state of Salzburg state, Heiligenblut is located in a high valley of the High Tauern range within the Central Eastern Alps. It is situated at the foot of the Grossglockner, the highest mountain in Austria, and of the Pasterze Glacier. Neighbouring peaks include the Johannisberg and the Fuscherkarkopf in the north, both part of the Alpine divide marking the Carinthia-Salzburg border. The municipal area comprises the cadastral communities of Apriach, Rojach, and Zlapp und Hof.