Oreophryne biroi is a species of frog in the family Microhylidae. It is endemic to New Guinea and occurs on the north coast from Madang Province in Papua New Guinea to the Cyclops Mountains in Papua province, Western New Guinea (Indonesia). The specific name biroi honours Lajos Bíró, a Hungarian zoologist and ethnographer who collected the holotype. Common name New Guinea cross frog has been coined for it.