Traversing a from Newport, Tennessee, to North Corbin, Kentucky, US 25E connects the cities of White Pine, Morristown, Bean Station, Tazewell and Harrogate in Tennessee. Entering Kentucky via the Cumberland Gap Tunnel, it connects the cities of Middlesboro and Barbourville. In North Corbin, after merging back with US 25W, a US 25E connector continues west to I-75.