Northwest of Tazewell, the road bridges the Powell River, and then passes through Harrogate. In the town of Cumberland Gap, Tennessee, US 25E serves as the western terminus of US 58. US 25E used that highway en route to the Cumberland Gap prior to 1996; however, it now uses a new highway leading to the Cumberland Gap Tunnel, freeing up a portion of road that US 58 now uses. US 25E then passes through the tunnel, emerging on the other side in Kentucky.