Phu Kao-Phu Phan Kham National Park is located about northwest of the city of Khon Kaen in the Ubolratana and Phu Wiang districts of Khon Kaen Province and the Non Sang district of Nong Bua Lamphu Province. The park's area is . The park's western section is located in the Phu Kao mountain range and the eastern section in the Phu Phan Kham mountain range of the Phu Phan Mountains.