The volcano is associated with a mountain range of the same name. The Sairecabur range forms a drainage divide between the Salar de Atacama on the western side and a number of small endorheic basins in Bolivia on the eastern side. Licancabur and Juriques farther south and Tocorpuri farther north are part of the same divide. Dry valleys on the eastern side of the Sairecabur range ultimately drain into Laguna Verde. The Rio Purifica originates on Sairecabur's slope at an altitude of , it later converges with the Rio Puritama to form the San Pedro de Atacama River.