The South Pennines section is long, with 18 traffic-free. It runs from Holmfirth via Upperthong, Meltham and Slaithwaite, encountering the M62 motorway as it crosses the dam at Scammonden Reservoir. Passing through Barkisland, Sowerby Bridge, Mytholmroyd and Hebden Bridge (this part of the route is shared with National Cycle Route 66) to Heptonstall, where the route splits in two. To get to Colne in Lancashire, riders can either head to Burnley and through Towneley Park to join the towpath of the Leeds and Liverpool Canal, or past Widdop and Coldwell Reservoirs. Rejoining the canal at Foulridge, through Salterforth and Barnoldswick to West Marton in North Yorkshire, where the route crosses the A59, and on to Gargrave. Continuing through Winterburn and Airton (shared with the Way of the Roses) to Settle, and then Wharfe, Austwick, Clapham, and Ingleton to Dent, Cumbria. After encountering the M6 near Tebay Services, it is on to Orton, Great Asby and Sedbergh, to finish at Appleby in Cumbria. This part of the route includes connections to Kendal and Kirkby Stephen.