The Huzzah's headwaters are in the Mark Twain National Forest in northern Reynolds County. It flows northward through the Missouri Ozarks, roughly paralleling the course of Courtois Creek to its east, until it enters the Meramec River shortly after passing under the Crawford County Highway E bridge. Along its course it flows through the Dillard Mill State Historic Site and, near its confluence with the Meramec, the Huzzah Conservation Area.