After the Idaho-Wyoming state line, WYO 22 becomes Teton Pass, later passing through the community of Wilson, a census-designated place (CDP) west of Jackson. On the eastern border of Wilson, at , WYO 22 intersects the southern terminus of Wyoming Highway 390 (Moose-Wilson Road) before crossing the Snake River. WYO 22 then continues east to Jackson where it ends at U.S. Highway 26/89/189/191 (Broadway).