US 460 and US 221 continue northeast into Botetourt County along four-lane divided Blue Ridge Boulevard. The highways pass by the hamlet of Coyner Springs to the east of Coyner Mountain and through the community of Laymantown, where they meet the Blue Ridge Parkway at a partial cloverleaf interchange. US 460 and US 221 continue through the community of Blue Ridge and parallel Norfolk Southern Railway's Blue Ridge District across the spine of the Blue Ridge at low and wide Buford's Gap, just south of which the routes enter Bedford County. US 460 and US 221 gradually curve east as Lynchburg Salem Turnpike, parallel the South Folk of Goose Creek, and pass through the communities of Villamont and Montvale, between which the U.S. Highways pass to the south of the railroad. The routes cross the North Fork of Goose Creek just north of its confluence with the South Fork to form the main stream, then the carriageways briefly split wide where they and Goose Creek pass between Porters Mountain to the south and Taylors Mountain to the north as the U.S. Highways leave the Blue Ridge Mountains and enter the Virginia Piedmont.