Pristimantis permixtus (in Spanish: rana de muslos naranja, meaning Andean orange-thighed frog) is a species of frog in the family Craugastoridae. It is endemic to Colombia where it is found on the Cordillera Occidental and the Cordillera Central in Antioquia, Caldas, Quindío, Risaralda, Tolima, and Valle del Cauca departments.