Isthmohyla calypsa is a species of frogs in the family Hylidae. It is known from the southern Cordillera de Talamanca in Costa Rica, Cerro Pando in Costa Rica and Panama, and the Pacific slope in southwestern Panama. It appears to have gone extinct in Costa Rica. Prior to its description in 1996, this species was confused with Isthmohyla lancasteri, a species now known from lower altitudes only.