Porto Grande Bay (), also Mindelo Bay, is a bay on the north coast of the island of São Vicente, Cape Verde. The main city of São Vicente, Mindelo, is situated at the bay. The Porto Grande Bay is a natural harbour. It stretches between the headlands Ponta João Ribeiro in the northeast and Ponta do Morro Branco in the west. To the northwest it opens towards the Canal de São Vicente, the channel between the islands São Vicente and Santo Antão. The small rocky islet Ilhéu dos Pássaros lies north of the bay.