The mouth of Salt Creek is at its confluence with the Amargosa River at an elevation of 390 feet / 119 meters. Its source is at at an elevation of 890 feet in the north slope of the Soda Mountains northwest of Baker, California. From there it flows down into Silurian Valley to Dry Sand Lake at and then to another named Silurian Lake, flowing northwest, gathering in Kingston Wash from the east, before flowing out of the valley through the Salt Spring Hills to the Amargosa River beyond in Death Valley.