Corallus ruschenbergerii is found in Lower Central America in southwestern Costa Rica (south of 10° N) and Panama, including Isla del Rey, Isla Contadora, Isla de Cébaco and Isla Suscantupu. In South America it occurs in Colombia east of the Andes, north of the Cordillera Central and north of the Cordillera Oriental, northern Venezuela north of the Cordillera de Mérida and in the drainage of the Río Orinoco, north and west of the Guiana Shield, east of the Orinoco Delta. It is also found on Isla Margarita, Trinidad and Tobago. The type locality given is Panama.