Charadrahyla nephila is a species of frog in the family Hylidae. It is endemic to Mexico and occurs in the Sierra de Juárez and Sierra Mixe in the northern Oaxacan highlands; there is also a questionable record from the Sierra de los Tuxtlas, Veracruz. Prior to its description, it was mixed with Hyla chaneque (now Charadrahyla chaneque). The specific name nephila is derived from Greek nephos (cloud) and philia (fondness), referring to the cloud forest habitat of this species. Common name Oaxacan cloud-forest treefrog has been coined for it.