Main Ridge provides critical habitat for two endemic amphibians, Pristimantis turpinorum (Turpin's frog) and Mannophryne olmonae (Bloody Bay tree frog), which are endemic to northeastern Tobago and for the coral snake mimic Erythrolamprus pseudoreginae. The white-tailed sabrewing (Campylopterus ensipennis) is endemic to northeastern Venezuela and the Main Ridge; after Hurricane Flora in 1963 the hummingbird was thought to be extirpated from Tobago, but was rediscovered in 1974. Plant species endemic to Tobago which have been recorded from Main Ridge include Odontonema brevipes, Duguetia tobagensis, Phyllanthus acacioides, Besleria seitzii, Cybianthus pittieri, Pilea tobagensis, and Justicia tobagensis.