In Missouri, US 54 runs from the southwest portion of the state to the northeast. It is a major conduit through the Ozarks and is the primary access road to Pomme de Terre Lake and Lake of the Ozarks. After entering the state it passes through Nevada, El Dorado Springs, Hermitage, crossing Lake of the Ozarks the first time just north of Ha Ha Tonka State Park. It passes through Camdenton and crosses the lake a second time on the Grand Glaize Bridge at Osage Beach before bypassing Eldon and going through Jefferson City, where it crosses the Missouri River via the Jefferson City Bridge and briefly overlaps U.S. Route 63. Just north of the bridge, it splits passing through Fulton, crossing Interstate 70 at Kingdom City, bypassing Mexico, sharing a concurrency with Highway 19 through Laddonia, passing just north of Vandalia, and ultimately crossing the Mississippi River via the Champ Clark Bridge into Illinois at Louisiana.