From the origin in western Tokyo the expressway follows a westerly route through Kanagawa Prefecture, paralleling National Route 246 and passing to the north of Yokohama. The route continues west into Shizuoka Prefecture, passing to the south of Mount Fuji and along the coastline of Suruga Bay, paralleling National Route 1 and the historic Tōkaidō highway before reaching the city of Shizuoka. The expressway continues west, passing Lake Hamana in western Shizuoka Prefecture, and crosses into Aichi Prefecture. The expressway then heads northwest, passing to the east of the city of Nagoya and meeting the terminus of the Chūō Expressway before terminating at an interchange in the city of Komaki to the north of Nagoya. Although the Tōmei Expressway ends at this point, the roadway continues as the Meishin Expressway towards Kyoto, Osaka, and Kobe.