Kresna Gorge () is a steep valley in south-western Bulgaria, stretching about 18 km. The gorge has been formed by the Struma River, which flows from the Vitosha mountains. Kresna gorge has a rich biodiversity, which has come under pressure from the Struma motorway construction project, a new leg of the Trans European Corridor No. 4. In the south, the gorge bisects the Tisata nature reserve.