Wertzville is an unincorporated community in Silver Spring Township, Cumberland County, Pennsylvania along the southern foothill of Blue Mountain. The Simmons Creek flows south through the village to the Conodoguinet Creek, which flows generally east to the Susquehanna River. It is located on the NW terminus of Route 114 with Route 944 and is served by the Cumberland Valley School District. It is served by the Mechanicsburg post office with the zip code of 17050.