The region is bisected into east and west portions by Interstate 93 (from Campton to Littleton). Other major highways in the region include U.S. Highway 302 (Woodsville to Conway), New Hampshire State Route 16 (from Gorham to Conway), State Route 10 (from Littleton to Piermont), and U.S. Route 2 from Lancaster to Shelburne. U.S. Route 3 parallels I-93, except north of Franconia Notch, where it branches off to Twin Mountain and Whitefield.