The summit of Mount Sequoyah is among the most distant summits traversed by a trail in the Great Smokies. Following the Appalachian Trail from Newfound Gap, Mount Sequoyah is to the east. From the Cosby Campground, Sequoyah can be reached by following the Snake Den Ridge Trail to its junction with the Appalachian Trail, and then following the latter to Tricorner Knob, crossing Old Black and Mount Guyot along the way. From Tricorner, Mount Sequoyah is to the southwest, just beyond Mount Chapman. The Hughes Ridge Trail, which connects the Appalachian Trail and the Benton MacKaye Trail, terminates just over two miles (3 km) southwest of Sequoyah.