The populated part of Karakax county is located at the northern edge of the Karakoram mountains and southern part of Tarim basin (Taklamakan Desert). The Karakax river separates the county from Hotan County and the Hotan River separates the county from Lop County. The length from south to north is and width from east to width is . Mazartag is a prominent arc-shaped mountain range in the northern desert area of the county.