Pantherophis alleghaniensis is found in the United States east of the Apalachicola River in Florida, east of the Chattahoochee River in Georgia, east of the Appalachian Mountains, north to southeastern New York and western Vermont, eastern Pennsylvania, Maryland, South Carolina, North Carolina, Georgia, south to the Florida Keys. In the Florida Panhandle, it readily hybridizes with the gray rat snake (Pantherophis spiloides).