The route runs from Fulda, initially on the same tracks as the line via Hanau to Frankfurt am Main, the Kinzig Valley line. At Flieden it leaves the Kinzig Valley line and runs through the Spessart and Rhön foothills through the closed stations of Elm and Vollmerz, followed by Sterbfritz station, which remains open to passengers, and the abandoned stations of Mottgers and Altengronau Nord before reaching Jossa in the Sinn Valley.