The Macayepo massacre () occurred on October 14, 2000, resulting in the slaughter of fifteen peasants from Macayepo in the southern region of Bolívar Department, northern Colombia. It was one of a series of massacres perpetrated by the Colombian paramilitary bloc Héroes de los Montes de María, a unit of the United Self-Defense Forces of Colombia (AUC), to obtain control over the area around the Montes de María mountains. The massacre also involved congressman Álvaro García Romero who was subsequently accused as a possible mastermind of the massacre.