The range is bounded by the Tuxerjoch mountain pass to the north (separating it from the Tux Alps); the Birnlücke - Forcella del Picco pass to the east (separating it from the Hohe Tauern); the Eisack and its tributary the Rienz to the south (separating it from the Southern Limestone Alps); and the Brenner Pass to the west (separating it from the Stubai Alps).