The lake lies at an elevation of . It has a maximum depth of while its surface area is about ; due to seasonal evaporation and the gentle slopes of the lake floor it varies seasonally from in summer to in winter when the lake is sometimes partially frozen over. At times Tuyajto Lake is almost empty, and salts such as gypsum and halite can be seen on the edges. Wetlands occur on the eastern shores, and the local flora and fauna depend on the water supply to the lake. The Cordón de Puntas Negras separates Tuyajto Lake from Lejía Lake.