US 441 enters Tennessee at Newfound Gap. The route heads north through the Great Smoky Mountains National Park to Gatlinburg, along the Great Smoky Mountains Parkway, where the route meets U.S. Route 321. US 321 joins US 441 northward through Pigeon Forge before separating north of the city. US 441 continues north to Sevierville, where it intersects with U.S. Route 411. US 441 turns west onto US 411, following the route west to Seymour. Here, US 411 heads to the southwest towards Georgia while US 441 continues northwest to Knoxville.