Route 171 is a regional east-west road in southern Israel. It is the only east-west road in the Negev Mountains. It is 33 km long. It goes from Mount Harif (Hebrew: הר חריף‎) junction on Highway 10 adjacent to Israel's border with Egypt to HaRuhot junction with Highway 40 about 5 km north of Mitzpe Ramon. The road passes mostly along the northern edge of Makhtesh Ramon and along the flowing path of Nahal Nitzana. In its eastern portion it crosses HaRuhot Plain and passes by the Mitzpe Ramon Airport.