Purtscheller pioneered climbing without a mountain guide, who in the 19th century did all the route finding and lead climbing. By the end of his life he had recorded climbing over 1,700 mountains. A celebrated climb was the traverse of the Meije together with the Zsigmondy brothers in 1885, which to this date is considered a classic alpine route. He is best known as the first European to ascend Kilimanjaro in 1889, together with the German mountaineer Hans Meyer.