The Tupungato River (in Spanish: Río Tupungato) is a river located in the western zone of the Mendoza Province called Uco Valley (in Spanish: Valle de Uco), flows in Luján de Cuyo and Tupungato departments, to the west of Argentina. It arises on the Del Plomo and Del Juncal glaciers in the north of the Tupungato Mountain and ends at the Mendoza River. Its drainage basin has an area of 1,858 km² and is located in . Its source elevation is of 4,251 AMSL.