Plectrohyla hartwegi (common name: Hartweg's spikethumb frog) is a species of frog in the family Hylidae. It is found in the Sierra Madre de Chiapas and eastern Oaxaca in Mexico, Sierra de los Cuchumatanes in western Guatemala as well as Sierra de las Minas in eastern Guatemala, and Sierra de Omoa in southwestern Honduras. It might be a composite of two or more species.