The airport is located in the town of Kasese, Kasese District, in the Western Region of Uganda, at the foothills of the Rwenzori Mountains and close to the international border with the Democratic Republic of the Congo. It is approximately , by air, west of Entebbe International Airport, the country's largest civilian and military airport. The coordinates of Kasese Airport are: 0°11'27.0N, 30°06'10.0E (Latitude:0.190825; Longitude:30.102786).