The seal salamander can be found from southwestern Pennsylvania and south through Appalachian Mountains areas of high elevation in West Virginia, western Maryland, western and northern Virginia, eastern Kentucky, western North Carolina, eastern Tennessee, western South Carolina, and northern Georgia to central Alabama. There are also disjunctive populations in southern Alabama as well as at the very western end of the Florida panhandle. In the north of its range, it has not been observed north or west of the Ohio River.