The former National Bank of Australasia at Mossman is one of several historic buildings located in Mill Street, along which a tramline runs linking the Mossman Central Mill to cane farms west of the town. Other buildings along Mill Street include the Mossman Shire Hall and former Douglas Shire Council Building, Jack and Newell's General Store, the former Exchange Hotel and a refurbished picture theatre. The surrounding landscape is generally flat, sloping slightly towards the Mossman River and its tributaries. The distant views from the steps at the front of the bank are to Mount Demi and the Great Dividing Range to the west and to Mount Beaufort to the east.