The station of the glass-making town of Zwiesel was opened on 15 November 1877 along with the Bavarian Forest Railway. Since 1 September 1890, the station has been the starting point of the Zwiesel-Grafenau line. The Zwiesel-Bodenmais branch line was opened on 3 September 1928. Based on the four railway lines that run in all directions, the network around the station is also known as the Zwiesel spider (Zwieseler Spinne).