The Gundlakamma River () is a seasonal waterway that flows through the east-central part of the state of Andhra Pradesh, India. It arises in the Nallamalla Hills, an offshoot of the Eastern Ghats. Its main headwaters lie some 6 kilometers from the village of Ardhaveedu, Prakasam District at an altitude of 425 m. above MSL. Numerous mountain streams join it as it descends down the thickly forested hills through a series of curves and tight bends. It follows a north-easterly direction and enters the plains near Cumbum, after flowing through a town named after it. Gundlakamma is the largest of all the rivers that originate from the Nallamalla Hills.