Mittenwald is located approximately 16 kilometres to the south-east of Garmisch-Partenkirchen. It is situated in the Valley of the River Isar, by the northern foothills of the Alps, on the route between the old banking and commercial centre of Augsburg, to the north, and Innsbruck to the south-east, beyond which is the Brenner Pass and the route to Lombardy, another region with a rich commercial past and present.