Afrixalus uluguruensis is a species of frog in the family Hyperoliidae. Its common name is Uluguru banana frog. It is endemic to the Eastern Arc Mountains of Tanzania and known from the Kipengere Range (Livingstone Mountains), Mahenge, Udzungwa Scarp, Rubeho, North Uluguru, Nguru, Ukaguru, and Nguu Mountains.