The river has its origins in a fan-shaped group of canyons draining the western slopes of the Ruby Mountains in northeastern Nevada. These headwaters run from Ruby Dome south to King Peak, and include Echo, Box, Kleckner, North Furlong, Long, Segunda, Drown, and Rattlesnake Canyons. Streams draining these canyons exit the mountains and converge at an elevation of , near the town of Lee and within the tribal lands of the Te-Moak tribe of the South Fork Band of the Western Shoshone.