While distinct from most other glass frogs, there are no characters that could unambiguously place a species in Rulyrana or in the genus Sachatamia; genetic data are needed for an unambiguous allocation. The two genera, however, have largely disjunct distribution areas (Rulyrana are found in the Amazon Basin and the Colombian Cordillera Central while Sachatamia are not found further east than the Colombian Cordillera Central).