Between Potters Mills and Lewistown, US 322 is a limited-access road. Near Lewistown, it briefly overlaps US 522 and begins a long overlap with US 22. South of Lewistown, US 22/US 322 enters the Lewistown Narrows, an stretch of road through the Juniata River water gap in Shade Mountain. Construction to convert this section of the highway from a two-lane highway to a divided, limited-access four-lane highway was completed in December 2007, and it includes building the longest mechanically stabilized earth wall in the U.S. The highway exits the narrows in Arch Rock, traverses Juniata County and Perry County, and crosses the Tuscarora Mountain through a water gap on a southeastward course along the banks of the Juniata River. After crossing the Susquehanna River on the Clarks Ferry Bridge (coinciding with the Appalachian Trail), the freeway runs south and parallels the river for before entering the Harrisburg Area. The section of US 322 between State College and Harrisburg serves as a major access road to Pennsylvania State University from points to the southeast and experiences traffic congestion on Penn State Nittany Lions football home game days.