Highway 154 begins at a junction with Highway 27 in unincorporated Yell County northeast of Danville. From here, the route heads east through a rural area to Mount George, where it meets Highway 28. The highway continues east from Mount George to an intersection with Highway 7 in Centerville. It leaves Centerville to the east, passing through the community of Liberty Hall before meeting Highway 155 in a farmed region. Past Highway 155, the road dips south around Winthrop Rockefeller Lake, running through the communities of New Neely and Cotton Town before reaching the Conway County line at the Petit Jean River.