After shakedown along the California coast, Missoula steamed from San Francisco to Pearl Harbor 6 to 12 December. She trained in Hawaiian waters during the next 6 weeks; thence, with units of the 5th Marine Division embarked, she sailed 27 January 1945, for the scheduled invasion of Iwo Jima. Among her troops she carried the men who on two separate occasions raised the American flag atop Mount Suribachi during bitter fighting 23 February. Assigned to Transport Squadron 16, she steamed via Eniwetok to the staging area at Saipan, where she completed final preparations for the invasion.