The Copper River rises out of the Copper Glacier, which lies on the northeast side of Mount Wrangell, in the Wrangell Mountains, within Wrangell-Saint Elias National Park. It begins by flowing almost due north in a valley that lies on the east side of Mount Sanford, and then turns west, forming the northwest edge of the Wrangell Mountains and separating them from the Mentasta Mountains to the northeast. It continues to turn southeast, through a wide marshy plain to Chitina, where it is joined from the southeast by the Chitina River (Ahtna Athabascan Tsedi Na' ] < tsedi copper + na' river).