The municipal territory extends on both banks of the Main about halfway between Würzburg and Aschaffenburg in Lower Franconia. The town of Lohr lies on the eastern slope of the Spessart at a bend in the river Main, which swings towards the south here, forming the beginning of the Mainviereck (Main Square - the southern part of the Spessart). In Lohr, the river Lohr empties into the Main. Perhaps for its geographical location or the fact that two major valleys lead into the interior of the range, the town is known as the Gateway to the Spessart (Tor zum Spessart).