The southern slopes of the Liverpool Range are drained by the headwaters of the Hunter River and its tributaries, such as the Pages River, which flows through the town of Murrurundi. The northern slopes are drained by the headwaters of the Peel River and the Mooki River. The Talbragar River and the Coolaburragundy River also rise on the range and flow south-west, joining near the town of Dunedoo.