Wyatt was working as a nurse anesthetist in a hospital in Madison, Tennessee, when in 1960, he saw a picture in Life of the Durupınar site, a boat-like shape on a mountain near Mount Ararat. The resulting widespread speculation in evangelical Christian circles that this might be Noah's Ark started Wyatt on his career as an amateur archaeologist. From 1977 until his death in 1999 he made over one hundred trips to the Middle East, his interests widening to take in a wide variety of references from the Old and New Testaments.