US 48 then descends the Allegheny Front near Bismarck. It then crosses Patterson Creek Mountain to reach Moorefield, where it crosses the South Branch Potomac River. It then ascends South Branch Mountain, during which it crosses the Clifford Hollow Bridge, and then descends to Baker. The highway then follows the Lost River and Cacapon River down to Wardensville, where the four-lane highway again ends. It then ascends to the ridge of Great North Mountain, where it crosses the border into Virginia.