During the third and final ascent of the Mur de Huy at La Flèche Wallonne, Alaphilippe accelerated near its summit, overtaking the sole race leader Jelle Vanendert in the last 100 metres of the race and dropping him. Alejandro Valverde, who had won the last four La Flèche Wallonne editions, staged a late fight-back and almost caught Alaphilippe, but the latter was able to kick again in the final metres to increase his lead over Valverde and eventually win the race. It was the biggest victory of Alaphilippe's career at that point, and he was the first French winner of La Flèche Wallonne since Laurent Jalabert won in 1997.