The hut can only be accessed on foot. The traditional approach starts from Alagna Valsesia, the town where was organized the first ascent to the summit in 1842 realized by the parish priest of Alagna Valsesia, Giovanni Gnifetti. The walk to the hut usually takes two days; climbers spend a night at the Gnifetti Hut, the Monte Rosa Hut or the Resegotti Hut (from the last one the climb is very difficult and technical since you have to climb the Signal ridge), from where they set off for the Margherita Hut on the following morning. The walk requires physical fitness and a good knowledge of alpine techniques.