La Pacana is part of the Central Volcanic Zone, one of the four volcanic zones that make up the Andean Volcanic Belt and which are separated from each other by gaps without ongoing volcanic activity. A number of stratovolcanoes and ignimbrite-forming centres have erupted in the Central Volcanic Zone since the Miocene, about 50 of which are considered to be active. In addition, the Central Volcanic Zone features about 18 minor volcanic fields. The largest historical eruption of the Andes occurred in 1600 at Huaynaputina in Peru in the Central Volcanic Zone, and the most active volcano of the Central Volcanic Zone is Láscar in Chile.