Sellers took influence from the Nacoochee Valley, where her grandmother lived, ultimately focusing many of her poems on the relationship between man and the nature in Appalachia, giving specific reference to many well-known places in Georgia, such as Brasstown Bald, the highest point in Georgia. Along with nature, many of her poems focus on hardship and the different troubles that arose in the Appalachian region and in life in general, including birth and death and marriage and divorce. Her focus on biblical aspects can be seen through some of Seller's poem names, such as Sarah Quilts, based on the story of Cain and Abel, display Seller's importance in her belief in the Christian faith. Aside from the man and nature interaction, and the hardships of the Appalachian region and life, other recurring themes in Sellers' poetry include seasonal change, natures complex beauty, and the preservation of nature. Sellers recognizes the threat that modern technology is to beautiful places and often portrays this technology as evil or an intruder in her poetry. Sellers' poetry is very descriptive and visual, bringing all of the beauty of northern Georgia to life. Sellers often describes native plants and animals in her works. This imagery Sellers is able to deliver to her audience distinguishes her work.