Centrolene acanthidiocephalum , commonly known as the Santander giant glass frog, is a species of frog in the family Centrolenidae. Its current placement within the subfamily Centroleninae is uncertain (incertae sedis). It is endemic to Colombia where it is only known from the region of the type locality on the western slope of the Cordillera Oriental in the Santander Department, at the elevations of asl.