The upper portion of the creek is paralleled by the Seneca Creek Trail, a 5-mile trail that begins at the Eastern Continental Divide on National Forest Road 112 and ends at its junction with the Horton Trail. The trail is part of the Seneca Creek Backcountry trail system, a 60-mile network of trails that extends from the Eastern Continental Divide down into the towns of Whitmer and Onego and is bounded by Gandy Creek to the west and Spruce Mountain to the east.