SR 111 enters the southeast corner of the Coachella Valley as a two-lane highway. It used to run concurrently with SR 86 in Coachella, but SR 86 has since been moved to a newer expressway alignment, which was formerly named SR 86S. SR 111 continues northwest as a major arterial road, four lanes or wider, through Indio, La Quinta, Indian Wells, Palm Desert, Rancho Mirage, and Cathedral City. As it approaches this area, the northbound traffic is on Indian Canyon Road, and the southbound is on Palm Canyon Road. An alternate Route runs on Gene Autry Trail while mainline SR 111 continues west on Vista Chino Drive. Continuing west from Cathedral City, the highway enters Palm Springs, then swings north and then west to bypass downtown, while SR 111 Business passes through the congested downtown area. The highway widens from an arterial road to a divided expressway as it exits Palm Springs just northwest of San Rafael Drive. It ends at an interchange with I-10 near the foot of San Jacinto Peak, just east of the San Gorgonio Pass.