Interstate 93 runs along the southern edge of the CDP, with access from Exit 41 (Cottage Street/US 302) and Exit 42 (Meadow Street/US 302). I-93 leads northwest to St. Johnsbury, Vermont, and south through the White Mountains' Franconia Notch to Concord, the capital of New Hampshire. U.S. Route 302 is Littleton's Main Street. To the east it turns up Cottage Street and Bethlehem Road, leading to Bethlehem, while to the west it turns onto Meadow Street and leads southwest to Woodsville. New Hampshire Route 116 runs out of town on Union Street, leading northeast to Whitefield.