House Mountain rises from a large plain in eastern Knox County, about southwest of the southern terminus of Clinch Mountain and immediately north of McAnnally Ridge. House, McAnnally, and Clinch are all part of the Appalachian Ridge-and-Valley Province, which consists of a series of narrow, elongate ridges stretching in a northeast-to-southwest direction between the main Appalachian crest to the east and the Cumberland Plateau to the west. These ridges are typically flanked by fertile river valleys that are part of the upper Tennessee River watershed.