Lohr am Main is economically the most important centre in the Main-Spessart district. Out of some 12,000 workers on the social welfare contribution rolls working in town, only some 5,500 actually live in Lohr. The greater number of roughly 6,200 workers commute each day to Lohr. Comparing Lohr am Main with the district seat of Karlstadt, Lohr's importance stands out even more sharply. Although both towns have roughly the same population, Lohr am Main has about three times as many jobs. The greater number of jobs and the number of large businesses in town are also reflected in per-capita tax revenue: in 2005, this was about €1,000.