A traditional thoroughfare of desert-dwelling Native Americans, the Mohave Trail much later served Spanish missionaries, explorers, and foreign colonizers and settlers from the 18th to 19th centuries who called it the Mojave Trail, and ran between watering holes across the Mojave Desert between the Colorado River and Mojave River then following it to the Cajon Pass, the gap between the San Bernardino Mountains and San Gabriel Mountains, into Southern California ending at Drum Barracks. The watering holes recur at intervals of about to .