De Sanctis a member of the Vesta family (401) when applying the hierarchical clustering method to its proper orbital elements. Vestian asteroids have a composition akin to cumulate eucrites and are thought to have originated deep within 4 Vesta's crust, possibly from the Rheasilvia crater, a large impact crater on its southern hemisphere near the South pole, formed as a result of a subcatastrophic collision. Based on osculating Keplerian orbital elements, De Sanctis has also been classified as a member of the Flora family (402), a giant asteroid family and the largest family of stony asteroids in the main-belt.