Her best-known flights were made in 1934 and earned her a Harmon Trophy. Ingalls flew in a Lockheed Air Express from Mexico to Chile, over the Andes Mountains to Rio de Janeiro, to Cuba and then to Floyd Bennett Field in New York, marking the first flight over the Andes by an American woman, the first solo flight around South America in a landplane, the first flight by a woman from North America to South America, and setting a woman's distance record of 17,000 miles.