The rugged summits of Makalu, with the fifth highest mountain of the world, Chamalang (), Baruntse () and Mera () are included in the national park. The protected area extends to about from west to east and to about from north to south. From the Arun river valley in the southeast, located at altitudes of , elevation gains about to the peak of Makalu. The national park shares the international border with the Qomolangma National Nature Preserve of the Tibet Autonomous Region in the north.