The city is located at the foot of the Italian Alps, and acts as a minor passenger-rail hub. Its strategic location accommodates Swiss rail passengers, and Domodossola railway station acts as an international stopping-point between Milan and Brig (a Swiss city of German language) through the Simplon Pass (Italian: Sempione). The Domodossola-Locarno railway is a line to the east across the border to Locarno.