Sulphide Creek is a glacial tributary of the Baker River in Whatcom County in the U.S. state of Washington, draining a steep and narrow canyon on the southeast flank of Mount Shuksan, inside North Cascades National Park. Although called a creek, it is river-like due to its high volume. The creek is fed by the massive Sulphide and Crystal glaciers above Sulphide Lake and it runs east collecting several small tributaries before flowing into the Baker River at elevation . There are several very tall waterfalls occurring on the creek and its tributaries, the largest of which is Sulphide Creek Falls.