The district was acquired by the East India Company with the Dewani Grant from the Mughal Emperor in 1765. At that time its greater part was included in the Niabat (Sub-Province of Dhaka) and a small portion in the Zamindaries of Atia, Kagmari, Pukuria and Patilandaha (of Rahahahi Zamindari). At the time of Permanent Settlement, it included northwest Garo-Hills and the Brahmandaria Subdivision of the Present Comilla district but did not include north Tangail and north-west part of Jamalpur. In 1799 Taluk Amirabad was transferred to Tippera (Comilla). In 1809, Patiladaha, situated north-east of the Brahmaputra came to district form Rangpur. In 1811, the river Banar and Brahmaputra were declared boundary between Dhaka and Mymensingh district and the river Brahmaputra and Meghna as boundary between Tippera (now Comilla) and Mymensingh and Dhaka. In 1811 west Gar-Hills were transferred to Rangpur district. In 1812 Patiladaha, was retransferred to Rangpur. In 1830, Parganas Sarail, Daudpur, haripur, Bejra, and Satarakhandal, were transferred to Tippera and Public convenience. In 1855, due to change in river course part or Serajganj thana was transferred from Mymensingh to Pabna and in 1866, the whole of it was transferred to Pabna. In 1866, thana Dewangajn was transferred to Mymensingh from Bogra and thana Atia from Dhaka. In 1867 for the administrative convenience boundaries of five subdivisions (including Tangail) and Thanas were notified. In 1874 on the basis of survey, the district boundaries were notified. In 1874 the Jamuna (or Daokoba) River was declared the western boundary between Mymensingh and Bogra and as such, 165 villages were transferred to Bogra. In 1875, the Brahmaputra was Made the boundary between Mymensingh and Rangpur and the portion of Patiladaha, east of the river, was transferred to this district form Rangpur. In 1877, the Jamuna was declared the boundary between Pabna and Mymensingh, in the west. On the first of December 1969, Tangail subdivision was separated from Mymensingh and a new District of Tangail was formed. Then in 1977 another new district Jamalpur (including Sherpur) was formed.