The Mohawk Valley region of the U.S. state of New York is the area surrounding the Mohawk River, sandwiched between the Adirondack Mountains and Catskill Mountains. As of the 2010 United States Census, the region's counties have a combined population of 622,133 people. In addition to the Mohawk River valley, the region contains portions of other major watersheds such as the Susquehanna River.