The park encompasses , making it one of the largest protected areas in the eastern United States. The main park entrances are located along U.S. Highway 441 (Newfound Gap Road) in the town of Gatlinburg, Tennessee and Cherokee, North Carolina, and in Townsend, Tennessee. The park is internationally recognized for its mountains, waterfalls, biodiversity, and spruce-fir forests. In addition, the park also preserves multiple historical structures that were part of communities occupied by early settlers of the area.