State Highway 65 (SH 65) is a state highway in Colorado that crosses the Grand Mesa. The highway along with a road to Lands End Overlook were designated as the Grand Mesa Scenic and Historic Byway in 1996. SH 65's southern terminus is at SH 92 east of Delta, and its northern terminus is at Interstate 70 (I-70) and U.S. Route 6 (US 6) northeast of Palisade.