Amqui is located to the south of the Saint Lawrence River in the Matapédia Valley, which was formed by the Chic-Choc Mountains. The valley is of glacial origin and was formed during the Paleozoic era millions of years ago. The region is characterized by gentle slopes through which the Matapédia river snakes from the northwest to the southeast. The city is located at the confluence of the Humqui and Matapédia rivers.