In the initial episode, the gang are thrown off course on a trip to Honolulu in Daphne's plane, landing instead in Himalayas. While inside a temple, Scooby and Shaggy are tricked by two bumbling ghosts named Weerd and Bogel into opening the Chest of Demons, a magical artifact which houses the 13 most terrifying and powerful ghosts and demons ever to walk the face of the Earth. As the ghosts can only be returned to the chest by those who originally set them free, Scooby and Shaggy, accompanied by Daphne, Scrappy-Doo, and a young con artist named Flim Flam, embark on a worldwide quest to recapture them before they wreak irreversible havoc upon the world.