Sinilóan lies between the plains of the Sierra Madre Mountains and the Laguna de Bay, bounded between the municipality of Mabitac on the west, Pañguil on the east, Real, Quezon on the North and Laguna de Bay on the South. A river named Río Romelo runs through the center of the town and is used for fishing ground and irrigation purposes. The town proper or población is about from Manila, passing through Rizal Province major Highways Manila East Road or Marcos Highway, and about via the South Luzon Expressway passing the town of Santa Crúz, the capital of the province.