The standard, and only common, route on Wetterhorn Peak is the southeast ridge, which is accessed via the Matterhorn Creek drainage on the south side of the mountain. The trailhead is on the Henson Creek Road, accessible from Lake City. The route involves of ascent from the trailhead and some exposed scrambling (Class 3/4) on the ridge itself. The nearby east face is considered a high-quality advanced snow climb or extreme ski descent.