The Bergstraße-Odenwald Nature Park () is a nature park in southern Germany with an area of 3,500 km² that lies between the rivers Rhine, Main (river) and Neckar. In the south it overlaps in places with the Neckar Valley-Odenwald Nature Park on the territory of Baden-Württemberg. In the east it meets the Bavarian Spessart Nature Park at the River Main. The nature park covers parts of the states of Baden-Württemberg, Bavaria and Hesse.