At the outbreak of World War I the brigade was based in the city of Gemona with its two regiments fielding three battalions each and each of the battalions consisting of four companies and a machine gun section. The 6th Regiment was the first to see action on the Italian front when it tried to conquer the Plöcken Pass on 3 July 1916. Afterwards the brigade reinforced by two battalions of Alpini was given the task to conquer Monte Rombon. In 1916 the brigade was engaged in combat in the region of Kras. From 22 to 26 November 1917 the brigade defended the summit of Col della Berretta on the Monte Grappa massif during the Battle of Monte Grappa, which put an end the Austrian offensive after the Battle of Caporetto.