The range is situated between Pyramid Lake to the west and the dry Winnemucca Lake to the east. To the southeast is the Mud Lake Slough, which previously connected Pyramid Lake to Winnemucca Lake. To the northwest is the San Emido Desert with the Fox Range beyond. To the east, Winnemucca Lake separates the Lake Range from the Nightingale Mountains and the Selenite Range. To the west, beyond Pyramid Lake are the Virginia and the Pah Rah ranges.