Route 430 begins at an interchange with Route 1 (Trans-Canada Highway, Exit 16) in Deer Lake and it heads northwest to immediately cross the Humber River and have intersections with local roads leading to the Nicholsville neighbourhood and the town of Reidville. The highway now leaves Deer Lake and continues northwest through rural areas to have an intersection with Route 422 (Cormack Road) before it begins winding its way through the Long Range Mountains. Route 430 passes through Jack Ladder, Bonne Bay Pond, and Wiltondale, where it has an intersection with Route 431 (Bonne Bay Road), before passing through Gros Morne National Park. The highway now exits both the National Park and the mountain range as it passes through Rocky Harbour, where it meets a local road to Norris Point, before passing through neighbouring Lobster Cove, where it passes by the Lobster Cove Head Lighthouse. Route 430 begins heading up the western coastline of the Great Northern Peninsula (the Strait of Belle Isle side), passing through Bakers Brook, the Green Point portion of Gros Morne National Park, Sally's Cove (where it crosses the Western Brook), and Gulls Marsh. The highway now passes Gros Morne National Park's Western Brook Pond trailhead before passing through St. Pauls (where it crosses St. Paul's Bay). Route 430 has intersections with two local roads leading to Cow Head before passing through Three Mile Rock, Parson's Pond (where it crosses the Parson's Pond River), Portland Creek (where it crosses the creek of the same name), Daniel's Harbour, Bellburns, and River of Ponds (where it crosses the river of the same name) before the road turns more inland. The highway now passes through Hawke's Bay (where it crosses the Torrent River and Big East River) to meet a local road leading to Port Saunders and Port au Choix before Route 430 rejoins the coastline at Eddies Cove West. Route 430 passes through Barr'd Harbour and turns more inland again to pass through Castor River South (where it crosses the Castors River) to have intersections with local roads leading to the neighbouring settlements of Castor River North, Bartlett's Harbour, Reefs Harbour, Shoal Cove West, and New Ferolle before having an intersection with Route 432 (Main Point Highway/Grenfell Loop). The highway begins following the coastline again as it passes through Plum Point, where it meets a local road leading to Bird Cove and Brig Bay, before passing through Blue Cove, where it meets a local road leading to Pond Cove. Route 430 now has an intersection with a local road leading to Forrester's Point and Black Duck Cove before having an intersection with St. Barbe Ferry Road, which provides access to the town of St. Barbe and the Labrador Ferry. The highway passes northeastward through Anchor Point, Deadman's Cove, Flower's Cove, Savage Cove, Pines Cove, Green Island Cove, and Green Island Brook before turning eastward and inland after passing through Eddies Cove and just south of Watt's Point Ecological Reserve. Route 430 now passes by St. Anthony Airport, where it has another intersection with Route 432 (Main Point Highway/Grenfell Loop), before passing through Hare Island and having intersections with Route 435 (Cook's Harbour Road) and Route 436 (L'Anse aux Meadows Road). Route 430 crosses the Parkers River in between these two intersections. The highway now curves to the southeast to have an intersection with a local road leading to St. Anthony Bight, St. Carols, and Great Brehat before it enters St. Anthony, where Route 430 comes to an end at an intersection between West Street and Goose Cove Road just north of downtown.