Sinigaglia was a keen mountain climber in his youth, amassing an impressive catalogue of ascents in the Dolomites. He has been described as the first great Italian climber in the Dolomites. Two of his most famous climbs were first ascents on Croda da Lago and Monte Cristallo. His book, Climbing reminiscences of the Dolomites, was published in English in 1898, shortly after the Italian edition, and is still regarded as a classic of climbing literature.