The north face of Mount Guyot drains into the Little River, thence into the Ammonoosuc and Connecticut rivers, and into Long Island Sound in Connecticut. The southeast face of Guyot drains into Jumping Brook, thence into the North Fork of the East Branch of the Pemigewasset River, thence into the Pemigewasset and Merrimack rivers, and into the Gulf of Maine in Massachusetts. The southwest face of Guyot drains into the Franconia Branch of the East Branch of the Pemigewasset River.