To the east, Val Melaina borders with Casal Boccone (Z. IV), whose boundary is marked by the stretch of Via delle Vigne Nuove between Viadotto Antonio Segni and Via Monte Resegone. To the south-east, it borders with Quartiere Monte Sacro (Q. XVI), from which is separated by Via Monte Resegone, Via Monte Massico, Via di Valle Melaina, Piazzale Jonio and Via dei Prati Fiscali up to Ponte Salario.