Hoodoo Butte is part of the Sisters Reach, which extends from South Cinder Peak to Crane Prairie Reservoir, running for . With at least 466 volcanoes active during the Quaternary, it has a high vent density, with many mafic (rich in magnesium and iron) volcanoes of Pleistocene to Holocene age. Hoodoo Butte is one of the larger mafic volcanoes, along with Three Fingered Jack, North Sister, and the vents of the Mount Bachelor chain.