More than 500 British troops and perhaps a couple thousand settlers had died in the Ohio Valley, and of more than a dozen British forts, only Detroit, Niagara and Pitt remained standing at the height of this uprising. On October 7, 1763, the Crown issued Royal Proclamation of 1763, which forbade all settlement west of the Appalachian Mountains—a proclamation ignored by British settlers, and unenforced by the British military. Fort Pitt would remain in British hands, and would become a central hub for migrant settlers as they pushed west in ever larger numbers over the next decade.