Plectrohyla pokomchi is a species of frogs in the family Hylidae. It is endemic to central and eastern Guatemala and known from Sierra de Xucaneb and Sierra de las Minas at elevations of above sea level. Its specific name refers to the Poqomchi' people, a group of Indian people from the Guatemalan highlands. Common name Rio Sananja spikethumb frog has been coined for it.