Oreophryne unicolor is a species of frog in the family Microhylidae. It is endemic to West Papua, Indonesia, and known from the Wondiwoi Mountains at the base of the Wandammen Peninsula, Papua province. Frogs with similar call have been observed in the Fakfak Mountains, but it remains to be ascertained that these represent the same species. The specific name unicolor refers to the uniformly coloured dorsal side of the body.