On 9 September 1349, an earthquake sequence began in Italy's Apennine Mountains that severely affected the Molise-Latium-Abruzzi regions. Four moderate-large earthquakes devastated towns and villages across the central Italian peninsula, with damage even reported in Rome. These earthquakes originated from the Apennine fold and thrust belt fault network, with the first and most destructive shock's epicenter originating from the north-west Campania region. Paleoseimological data gathered from scarping, fault length, and collapsed sections of Venafro's Roman aqueduct indicates the epicenter of the main shock was likely along the Aquae Iuliae fault. The fault suspected of causing this earthquake occurred on the Aqua Iuliae fault along the Molise-Campania border.