The Galilee Basin straddles the Great Dividing Range and encompasses the headwaters of seven major river basins. The Thompson river and Barcoo river of the Cooper Creek system, the Diamantina River, the Flinders River in the north-west, the Bulloo River in the south, and the Warrego River in the south-east. The subregion also extends across the Great Dividing Range to the east and north-east into the headwaters of the Fitzroy river basin and Burdekin river basin. It also includes two nationally important wetlands, Lake Buchanan and Lake Galilee.