The creek turns southwest, flowing through Eagle Point. Four bridges span the stream in Eagle Point: East Main Street, Loto Street, and the Antelope Creek Bridge near RM 5 (RK 8), and Oregon Route 62 at RM 4 (RK 6). Near RM 3 (RK 5), Little Butte Creek receives Antelope Creek on the left. Antelope Creek is its largest tributary, draining . Agate Lake on Dry Creek is in the Antelope Creek watershed. At RM 1.5 (RK 2.4) the creek is crossed by Agate Road. It then flows into the Rogue River from its mouth at the Pacific Ocean. Little Butte Creek's mouth is in the Denman Wildlife Area, approximately southwest of Eagle Point, and about a mile southeast of Upper Table Rock.