US 160 enters Colorado near the Four Corners Monument. It goes northeast and intersects US 491, then turns north to enter Cortez with US 491. East of Cortez, a road leads south from US 160 to Mesa Verde National Park. It continues east to Durango, where it intersects US 550. After overlapping with US 550 south of Durango, US 160 turns east and meets US 84 at Pagosa Springs. It then goes northeast and crosses the Continental Divide at Wolf Creek Pass, the area made popular in 1975 in C.W. McCall's album Wolf Creek Pass.