Cortical influences of serotonin and glutamate on layer V pyramidal neurons.
Layer V pyramidal neurons constitute principle output neurons of the medial prefrontal cortex (mPFC)neocortex to subcortical regions including the intralaminarmidline thalamic nuclei, amygdala, basal ganglia, brainstem nuclei and the spinal cord. The effects of 5-hydroxytryptamine (5-HT) on layer V pyramidal cells primarily reflect a range of excitatory influences through 5-HT