Tetrahydrocannabinolic acid is a potent PPARγ agonist with neuroprotective activity.
Phytocannabinoids are produced in Cannabis sativa L. in acidic form and are decarboxylated upon heating, processing and storage. While the biological effects of decarboxylated cannabinoids such as Δ The effects of six phytocannabinoids on PPARγ binding and transcriptional activity were investigated. The effect of Δ Cannabinoid acids bind and activate PPARγ with higher potency than their decarboxylated products. Δ Δ