Sex, THC, and hormones Effects on density and sensitivity of CB
The recent NIH mandate to consider sex as a biological variable in preclinical research has focused attention on delineation of sex differences in behavior. To investigate mechanisms underlying sex differences in Δ Adult Sprague-Dawley rats underwent gonadectomy (GDX) or sham-GDX. Half of the GDX females and males received estradiol or testosterone replacement (GDXH), respectively. All rats were injected with vehicle or 30 mgkg THC twice daily for 1 week before brain collection. CP55,940-stimulated With exception of enhanced receptor activation in the hippocampi of female rats compared to males, vehicle-treated rats exhibited minimal sex differences in CB These results suggest that sex differences in the density and G-protein coupling of brain CB