Social genetic effects for drug use disorder among spouses.
Preclinical and human studies suggest that a social partners genotype may be associated with addiction-related outcomes. This study measured whether spousal genetic makeup is associated with risk of developing drug use disorder (DUD) during marriage and whether the risk associated with a spouses genotype could be disentangled from potentially confounding rearing environmental effects. Univariable and multivariable logistic regression analyses. Sweden. Men and women born between 1960 and 1990 and in opposite-sex first marriages before age 35 (n 294 748 couples). Outcome was DUD diagnosis (inclusive of opioids, sedativeshypnoticsanxiolytics, cocaine, cannabis, amphetamine and other psychostimulants, hallucinogens, other drugs of abuse and combinations thereof) obtained from legal, medical and pharmacy registries. The focal predictor was family genetic risk scores for DUD (FGRS-DUD), which were inferred from diagnoses in first- through fifth-degree relatives and weighted by degree of genetic sharing. FGRS-DUD were calculated separately for each partner in a couple. Marriage to a spouse with a high FGRS-DUD was associated with increased risk of developing DUD during marriage, OR There is relatively robust evidence that a persons risk for developing drug use disorder is associated with the genetic makeup of the persons spouse.