Monoamine receptor interaction profiles of 4-thio-substituted phenethylamines (2C-T drugs).
4-Thio-substituted phenethylamines (2C-T drugs) are potent psychedelics with poorly defined pharmacological properties. Because of their psychedelic effects, 2C-T drugs are sometimes sold as new psychoactive substances (NPSs). The aim of the present study was to characterize the monoamine receptor and transporter interaction profiles of a series of 2C-T drugs. We determined the binding affinities of 2C-T drugs at monoamine receptors and transporters in human cells that were transfected with the respective receptors or transporters. We also investigated the functional activation of serotonergic 5-hydroxytryptamine 2A (5-HT 2C-T drugs had high affinity for 5-HT The receptor binding profile of 2C-T drugs predicts psychedelic effects that are mediated by potent 5-HT