Selective adrenergic alpha2C receptor antagonist ameliorates acute phencyclidine-induced schizophrenia-like social interaction deficits in rats.
Social withdrawal is a core feature of the negative symptoms of schizophrenia. Currently available pharmacotherapies have only limited efficacy towards the negative symptoms, i.e., there is a significant unmet medical need in the treatment of these symptoms. We wanted to confirm whether selective adrenergic α Here, we used acute PCP administration and modified a protocol for testing social interaction deficits in male Wistar rats and then used this model to compare the effects of an α Acute PCP (1.5 mgkg s.c.) produced robust and reproducible deficits in social interaction behavior without affecting locomotor activity. The selective α Our findings confirm that α