Clearing the smoke around medical marijuana.
The hazy world of medical marijuana continues to cry out for clear data on which to base medical decision making and rational policy design. In this issue of Clinical Pharmacology Therapeutics, Abrams and colleagues report that vaporized cannabis does not meaningfully affect opioid plasma levels and may even augment the efficacy of oxycodone and morphine in patients with chronic non-cancer pain. This Commentary considers the implications of this work for clinical practice and further research initiatives.