Cannabinoid receptor-mediated disruption of sensory gating and neural oscillations A translational study in rats and humans.
Cannabis use has been associated with altered sensory gating and neural oscillations. However, it is unclear which constituent in cannabis is responsible for these effects, or whether these are cannabinoid receptor 1 (CB1R) mediated. Therefore, the present study in humans and rats examined whether cannabinoid administration would disrupt sensory gating and evoked oscillations utilizing electroencephalography (EEG) and local field potentials (LFPs), respectively. Human subjects (n 15) completed four test days during which they received intravenous delta-9-tetrahydrocannabinol (Δ