Relief from intractable phantom pain by combining psilocybin and mirror visual-feedback (MVF).
ALs leg was amputated resulting in phantom-limb pain (PLP). (1) When a volunteer placed her foot on or near the phantom - touching it evoked organized sensations in corresponding locations on ALs phantom. (2) Mirror-visual-feedback (MVF) relieved PLP, as did, phantom massage. (3) Psilocybin-MVF pairing produced synergistic effects, complete elimination of PLP, and reduction in paroxysmal episodes. (4) Touching the volunteers leg where AL previously had external fixators, evoked sensation of nails boring through the leg. Using a telescoping nail, we created the illusion of a nail being removed with corresponding pain relief. (5) Artificial flames produced warmth in the phantom.