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Many jurisdictions use Simulated driving performance was assessed in 14 infrequent cannabis users at two timepoints (30 min and 3.5 h) under three different conditions, namely controlled vaporization of 125 mg (i) THC-dominant (11% THC <1% CBD), (ii) THCCBD equivalent (11% THC 11% CBD), and (iii) placebo (<1% THC CBD) cannabis. Plasma and oral fluid samples were collected before each driving assessment. We examined whether For all participants, plasma and oral fluid THC concentrations were over the There appears to be a poor and inconsistent relationship between magnitude of impairment and THC concentrations in biological samples, meaning that