Effects of 5-HT2A receptor stimulation and blocking on immune response.
Experiments on CBA mice showed that selective stimulation of 2A serotonin receptors with DOI agonist (1 mgkg) led to suppression of the immune response and reduction of the spleen and peripheral blood CD8()T cell counts with the cytotoxicsuppressor function. Selective blockade of these receptors with ketanserin (1 mgkg) had an opposite effect immunostimulation with an increase in CD8()T cell count in the spleen. These data indicate the involvement of 2A serotonin receptors in immunosuppressive mechanisms of serotoninergic system.