Cluster randomised controlled trial of an online intervention to prevent ecstasy and new psychoactive substance use among adolescents final results and implications for implementation.
To evaluate the effectiveness of the online Cluster randomised controlled trial. Secondary schools in Australia. 1126 students (aged 14.9 years) from 11 schools. Five schools were randomly allocated to the four-lesson internet-based Students completed self-report surveys at baseline, post-test, 6, 12 and 24 months post-baseline. Intentions to use ecstasy and NPS (including synthetic cannabis and synthetic stimulants), knowledge about ecstasy and NPS and lifetime use of ecstasy and NPS were assessed. This paper reports the results at 24 months post-baseline. Mixed effects regressions were conducted to analyse intervention effects from baseline to 24 months. Post hoc analyses using Inverse Probability of Treatment Weighting compared controls with students who i) completed all four lessons (full dose) and ii) partially completed the intervention (≤three lessons, incomplete dose). Primary analyses found that controls were significantly more likely to intend on using synthetic cannabis compared with intervention group students (OR3.56, p0.01). Results from the weighted analyses indicated that controls reported significantly lower knowledge about ecstasy (p0.001) and NPS (p0.04) compared with the full-dose group. No significant differences were observed between the incomplete dose and control groups. The online intervention was effective in modifying students intentions to use synthetic cannabis up to 24 months however, this study highlights the importance of delivering prevention programmes in full to maximise student outcomes. ACTRN12613000708752.