The e-psychonaut drugs psychopharmacology.
The focus here was on the pharmacological and clinical pharmacological issues pertaining to the vast range of drugs (e.g. synthetic cannabimimetics, synthetic opioids, novel stimulants, novel psychedelics, PCPketamine-like compounds, prescribed medicinal compounds and popular psychotropic herbsplants) discussed by Internet-based enthusiasts of newnovel psychoactive substances (NPS), e-psychonauts. Currently ongoing related in silico studies, followed by further in vitro and in vivopreclinical studies, will hopefully provide important findings in terms of which molecules within each given NPS class may present with higher levels of receptor affinities, and hence clinical potency. Understanding the pharmacological characteristicspotency of those novel recreational molecules will hopefully help in predicting related NPS diffusion, morbidity and possible lethality data.