Individual and combined effects of cannabidiol and Δ
Cannabidiol (CBD) and Δ To examine effects of THC, CBD, and THC CBD on functional connectivity of striatal sub-divisions (associative, limbic and sensorimotor). Resting-state functional Magnetic Resonance Imaging (fMRI) was used across two within-subjects, placebo-controlled, double-blind studies, with a unified analysis approach. Study 1 ( THC strongly disrupts striato-cortical networks, but this effect is mitigated by co-administration of CBD in the limbic striatum network. Oral CBD administered has a more complex effect profile of relative increases and decreases in connectivity. The insula emerges as a key region affected by cannabinoid-induced changes in functional connectivity, with potential implications for understanding cannabis-related disorders, and the development of cannabinoid therapeutics.