Effect of prior foot shock stress and Δ
Cannabis is commonly used by humans to relieve stress. Here, we evaluate the potential of intraperitoneally (i.p.) administered Δ In the absence of the explicit FS stressor, THC (1 and 10 mgkg) produced anxiogenic-like responding when administered acutely or chronically, but CBDA produced neither anxiogenic- nor anxiolytic-like responding. Administration of FS stress 24 h prior to the LD test enhanced anxiogenic-like responding (reduced time spent and increased latency to enter the light compartment) in rats pretreated with either vehicle (VEH) or THC (1 mgkg) however, administration of CBDA (0.1-100 μgkg) or CBD (5 mgkg) prevented the FS-induced anxiogenic-like responding (an anxiolytic-like effect). The 5-hydroxytryptamine 1A (5-HT These results suggest the anxiolytic effects of CBDA and CBD may require the presence of a specific stressor.