5-HT
Although the bulk of research into the biology of serotonin 5-HT An 18-week ovalbumin challenge period was performed to generate persistent, chronic asthma in BALBc mice. Four once daily intranasal treatments of (R)-DOI were administered one week after allergen cessation, with respiratory parameters being measured by whole-body plethysmography (WBP). Cytokine and chemokine levels were measured by quantitative real-time polymerase chain reaction (qRT-PCR) in homogenized lung tissue, bronchoalveolar (BALF) fluid was analyzed for chemokine modulation by multiplex assays, and Periodic Acid-Schiff and Massons Trichrome staining was performed to determine goblet cell infiltration and overall changes to lung morphology. 5-HT Overall, these data provide support for the therapeutic potential of (R)-DOI and 5-HT