Extinction training following cocaine or MDMA self-administration produces discrete changes in D
Several studies strongly support the role of the dopamine D The present study employed cocaine or MDMA self-administration with yoked-triad procedure in rats to explore whether extinction training affects the drug-seeking behavior and the D Both cocaine and MDMA rats developed maintenance of self-administration, but MDMA evoked lower response rates and speed of self-administration acquisition. During reinstatement tests, cocaine or MDMA seeking behavior was produced by either exposure to the drug-associated cues or drug-priming injections. The extinction training after cocaine self-administration did not alter significantly D This study first time shows that abstinence followed extinction training after cocaine or MDMA self- or passive-injections changes the D