The Varieties of the Psychedelic Experience A Preliminary Study of the Association Between the Reported Subjective Effects and the Binding Affinity Profiles of Substituted Phenethylamines and Tryptamines.
Classic psychedelics are substances of paramount cultural and neuroscientific importance. A distinctive feature of psychedelic drugs is the wide range of potential subjective effects they can elicit, known to be deeply influenced by the internal state of the user (set) and the surroundings (setting). The observation of cross-tolerance and a series of empirical studies in humans and animal models support agonism at the serotonin (5-HT)