Cannabidiol-Δ
Previous studies suggest that cannabidiol (CBD) may potentiate or antagonize Δ In Experiment 1, CBD (0, 10 or 30mgkg) was administered 15min before THC (0, 1.8, 3.2, 5.6 or 10mgkg), and rats were tested for antinociception and locomotion 15-360min post-THC injection. In Experiments 2 and 3, CBD (30mgkg) was administered 13h or 15min before THC (1.8mgkg) rats were tested for antinociception and locomotion 30-480min post-THC injection (Experiment 2), or serum samples were taken 30-360min post-THC injection to examine CBD modulation of THC metabolism (Experiment 3). In Experiment 1, CBD alone produced no antinociceptive effects, while enhancing THC-induced paw pressure but not tail withdrawal antinociception 4-6h post-THC injection. CBD alone increased locomotor activity at 6h post-injection, but enhanced THC-induced hypolocomotion 4-6h post-THC injection, at lower THC doses. There were no sex differences in CBD-THC interactions. In Experiments 2 and 3, CBD did not significantly enhance THCs effects when CBD was administered 13h or 15min before THC however, CBD inhibited THC metabolism, and this effect was greater in females than males. These results suggest that CBD may enhance THCs antinociceptive and hypolocomotive effects, primarily prolonging THCs duration of action however, these effects were small and inconsistent across experiments. CBD inhibition of THC metabolism as well other mechanisms likely contribute to CBD-THC interactions on behavior.