Ethanol induced antidepressant-like effect in the mouse forced swimming test modulation by serotonergic system.
The present investigation explored the modulatory role of serotonergic transmission in the acute ethanol-induced effects on immobility time in the mouse forced swim test (FST). Acute i.p. administration of ethanol (20% wv, 2 or 2.5 gkg, i.p.) decreased the immobility time in FST of mice, indicating its antidepressant-like effect while lower doses of ethanol (1, 1.5 gkg, i.p.) were devoid of any effect in the FST. The mice pre-treated with a sub-effective dose of 5-HT Thus, the results of the present study points towards the essentiality of the central 5-HT transmission at the synapse for the ethanol-induced antidepressant-like effect in the FST wherein the regulatory role of the 5-HT