Stability of drugs of abuse in synthetic oral fluid investigated using a simple dilute and inject method of analysis.
Human oral fluid is well established as a matrix for drug screening, particularly in the workplace. The need to synthesise synthetic oral fluid (SOF) has been recognised in order to overcome human oral fluids composition variability. We have used SOF spiked with six common drugs of abuse or their primary metabolites morphine, amfetamine, benzoylecgonine, cocaine, diazepam, and (-)-Δ