Sex, species and age Effects of rodent demographics on the pharmacology of ∆
Cannabis edibles are becoming more common in an increasingly diverse population of users, and the impact of first pass metabolism on cannabiss pharmacological profile across age and sex is not well understood. The present study examined the impact of age, sex and rodent species on the effects of intraperitoneal (i.p.) delta-9-tetrahydrocannabinol (THC) and its primary psychoactive metabolite, 11-OH-THC, in rodent models of psychoactivity and molecular assays of cannabinoid receptor type-1 (CB