Contrasting effects of DOI and lisuride on impulsive decision-making in delay discounting task.
The 5-HT The current study aims to compare the effects of DOI and lisuride on impulsive decision-making and further to investigate the possible receptor mechanisms responsible for the actions of the two drugs. Impulsive decision-making was evaluated in male Sprague-Dawley rats by the percentage of choice for the LR in delay discounting task (DDT). Delay to the LR changed in an ascending order (0, 4, 8, 16, and 32 s) across one session. DOI (0.5 and 1.0 mgkg) increased impulsive decision-making, and the effects of DOI (1.0 mgkg) were blocked by the 5-HT DOI and lisuride have contrasting effects on impulsive decision-making via distinct receptors. DOI-induced increase of impulsivity is mediated by the 5-HT