The short-acting synthetic cannabinoid AB-FUBINACA induces physical dependence in mice.
Recent years have seen a rise in the diversity and use of synthetic cannabinoids. The present study evaluated the behavioral effects of the third-generation indazole-3-carboxamide-type synthetic cannabinoid, AB-FUBINACA. Adult male and female C57BL6J mice were treated with AB-FUBINACA (0-3 mgkg, i.p.) and tested repeatedly in the tetrad battery measuring catalepsy, antinociception, hypothermia, and locomotor activity. Mice treated with AB-FUBINACA (≥2 mgkg, i.p.) displayed classic cannabinoid effects in the tetrad that were blocked by the CB Although mice did not develop tolerance to AB-FUBINACA or cross-tolerance to Δ These data indicate that the cannabinoid effects of AB-FUBINACA are relatively short-lived, yet sufficient to induce dependence in mice.