d-Lysergic Acid Diethylamide (LSD) as a Model of Psychosis Mechanism of Action and Pharmacology.
d-Lysergic Acid Diethylamide (LSD) is known for its hallucinogenic properties and psychotic-like symptoms, especially at high doses. It is indeed used as a pharmacological model of psychosis in preclinical research. The goal of this review was to understand the mechanism of action of psychotic-like effects of LSD. We searched Pubmed, Web of Science, Scopus, Google Scholar and articles reference lists for preclinical studies regarding the mechanism of action involved in the psychotic-like effects induced by LSD. LSDs mechanism of action is pleiotropic, primarily mediated by the serotonergic system in the Dorsal Raphe, binding the 5-HT