Effects of tetrahydrocannabinols on human oral cancer cell proliferation, apoptosis, autophagy, oxidative stress, and DNA damage.
Cannabinoids, including delta-8- and delta-9-tetrahydrocannabinol (THC) have a palliative care impact and may therefore be beneficial against cancer. The aim of this study was to investigate the effect of Δ The Ca9-22 oral cancer cells were cultured in the presence or not of various concentrations of Δ Both cannabinoids were found to decrease cell viabilityproliferation by blocking the cell cycle progression from the S to the G2M phase and enhancing their apoptosis and autophagy. Δ We demonstrated that cannabinoids (Δ