Impact of tetrahydrocannabinol on the endocannabinoid 2-arachidonoylglycerol metabolism ABHD6 and ABHD12 as novel players in human placenta.
Cannabis use has been increasing worldwide for recreational and medical purposes. Consumption by pregnant women is associated with disturbances in pregnancy outcome, such as low birth weight, prematurity and intrauterine growth retardation, though the underlying biochemical mechanisms are unknown. The endocannabinoid system is involved in several reproductive events and the disruption of its homeostasis by ∆