The protective effects of Δ
A large amount of fructose is metabolized in the liver and causes hepatic functional damage. Δ Sprague-Dawley rats were divided into groups control, fructose (10% fructose in drinking water for 12 weeks), THC (1.5 mgkgday for the last 4 weeks, intraperitoneally) and fructoseTHC groups. Biochemical parameters were measured spectrophotometrically. ELISA method was used for insulin measurement. Apoptosis and inflammation markers were detected by the streptavidin-biotin peroxidase method. The consumptions of food and fluid are inversely proportional to fructose and non-fructose groups. Insulin levels were the highest in fructose group. The reduced glutathione-S-transferase level significantly increased in fructose THC group compared with fructose group. Total cholesterol level in the fructose THC group was higher than the fructose group. Caspase-3 and NF-κβ immunopositive cell numbers increased in fructose THC rats compared with fructose group. The number of IL-6 immunopositive cell decreased in fructose THC group compared with fructose group. According to the result, long-term and low-dose THC administration may reduce hyperinsulinemia and inflammation in rats to some extent.