Detection of monoamine oxidase a in brain of living rats with 18Ffluoroethyl-harmol PET.
The efficient radiosynthesis for the MAO-A ligand (18) Ffluoroethyl-harmol is reported. Initial PET examinations reveal the ligand to be retained throughout rat brain during 90 min, whereas pretreatment with pargyline results in substantially increased washout, from which binding potentials in the range of 1.4-2.1 can be calculated.