Effect of combined doses of Δ
This study evaluated the potential of combined cannabis constituents to reduce nausea. Using the lithium chloride (LiCl)-induced conditioned gaping model of nausea in male rats, we aimed to 1) Determine effective anti-nausea doses of cannabidiol (CBD) 2) Determine effectiveness and the mechanism of action of combined subthreshold doses of CBD and Δ Combinations of very low doses of CBD THC or CBDA THCA robustly reduce LiCl-induced conditioned gaping. Clinical trials are necessary to determine the efficacy of using single or combined cannabinoids as adjunct treatments with existing anti-emetic regimens to manage chemotherapy-induced nausea.