Effects of psilocybin versus escitalopram on rumination and thought suppression in depression.
Major depressive disorder is often associated with maladaptive coping strategies, including rumination and thought suppression. To assess the comparative effect of the selective serotonin reuptake inhibitor escitalopram, and the serotonergic psychedelic psilocybin (COMP360), on rumination and thought suppression in major depressive disorder. Based on data derived from a randomised clinical trial ( A time×condition interaction was found for rumination (F(1, 56) 4.58, These data provide further evidence on the therapeutic mechanisms of psilocybin and escitalopram in the treatment of depression.