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Peroxisome proliferator-activated receptors (PPARs) are a family of ligand-activated nuclear transcription factors, with three characterized subtypes PPARα, PPARβδ, and PPARγ. The biological correlation between the two PPAR subtypes PPARα and γ and carcinogenesis is well-characterized however, substantially less is known about the biological functions of PPARβδ. PPARβδ has been reported to repress transcription when PPARβδ and PPARα or PPARγ are simultaneously expressed in some cells, and MDA-MB-231 cells express functional levels of PPARβδ. We have previously reported that Δ