The commerce of the ancient world was gathered into the warehouses of Tyre. "Tyrian merchants were the first who ventured to navigate the Mediterranean waters; and they founded their colonies on the coasts and neighbouring islands of the Aegean Sea, in Greece, on the northern coast of Africa, at Carthage and other places, in Sicily and Corsica, in Spain at Tartessus, and even beyond the pillars of Hercules at Gadeira (Cádiz)".
In the time of King David (c. 1000 BC), a friendly alliance was entered into between the Kingdoms of Israel and Tyre, which was ruled by Hiram I.
The city of Tyre was particularly known for the production of a rare and extraordinarily expensive sort of purple dye, produced from the murex shellfish, known as Tyrian purple. This color was, in many cultures of ancient times, reserved for the use of royalty, or at least nobility.
It was often attacked by Egypt, besieged by Shalmaneser V, who was assisted by the Phoenicians of the mainland, for five years, and by Nebuchadnezzar (586–573 BC) for thirteen years, without success, although a compromise peace was made in which Tyre paid tribute to the Babylonians. It later fell under the power of the Persians.
In 332 BC, the city was conquered by Alexander the Great, after a siege of seven months in which he built the causeway from the mainland to the island, but it continued to maintain much of its commercial importance until the Christian era. The presence of the causeway affected water currents nearby, causing sediment to build up, making the connection permanent.
In 315 BC, Alexander's former general Antigonus began his own siege of Tyre, taking the city a year later.
In 126 BC, Tyre regained its independence (from the Seleucids) and was allowed to keep much of its independence when the area became a Roman province in 64 BC.