diff --git "a/benchmarks/open_generation/MolOpt/LogP/test.csv" "b/benchmarks/open_generation/MolOpt/LogP/test.csv"
new file mode 100644--- /dev/null
+++ "b/benchmarks/open_generation/MolOpt/LogP/test.csv"
@@ -0,0 +1,5001 @@
+index,Instruction,molecule,logP
+173028,Modify the molecule Cc1ccnc(N2CCC(c3nc(C(F)(F)F)c[nH]3)CC2)c1[N+](=O)[O-] to decrease its LogP value.,Cc1ccnc(N2CCC(c3nc(C(F)(F)F)c[nH]3)CC2)c1[N+](=O)[O-],3.424120000000002
+114084,Please optimize the molecule CN(CC(=O)N1CCc2ccccc21)Cc1ccc(Cl)nc1 to have a lower LogP value.,CN(CC(=O)N1CCc2ccccc21)Cc1ccc(Cl)nc1,2.756100000000001
+174437,Modify the molecule C[C@H]1CC(=O)N(CC(=O)NCc2ccc(F)cc2C(F)(F)F)C1=O to have a lower LogP value.,C[C@H]1CC(=O)N(CC(=O)NCc2ccc(F)cc2C(F)(F)F)C1=O,1.8556999999999997
+1590,Please modify the molecule C[C@@H](Sc1ccc(Cl)cc1)C(=O)N[C@H](C)c1nc2ccccc2[nH]1 to decrease its LogP value.,C[C@@H](Sc1ccc(Cl)cc1)C(=O)N[C@H](C)c1nc2ccccc2[nH]1,4.574300000000004
+132258,Please modify the molecule CCN(CC)C(=O)c1ccc(N[C@H]2CCN(C(C)C)C2=O)cc1Cl to decrease its LogP value.,CCN(CC)C(=O)c1ccc(N[C@H]2CCN(C(C)C)C2=O)cc1Cl,3.2432000000000016
+239209,Optimize the molecule Cn1c(C[NH+]2CCC(CS(N)(=O)=O)CC2)nnc1-c1ccccc1 to have a lower LogP value.,Cn1c(C[NH+]2CCC(CS(N)(=O)=O)CC2)nnc1-c1ccccc1,-0.4344999999999968
+93903,Modify the molecule O=C(NN1C(=O)[C@@H]2C3c4ccccc4C(c4ccccc43)[C@H]2C1=O)c1cccc(Cl)c1 to decrease its LogP value.,O=C(NN1C(=O)[C@@H]2C3c4ccccc4C(c4ccccc43)[C@H]2C1=O)c1cccc(Cl)c1,3.8770000000000033
+216997,Please modify the molecule COc1cc(/C=C2/NC(=S)NC2=O)ccc1OC(=O)c1cccs1 to increase its LogP value.,COc1cc(/C=C2/NC(=S)NC2=O)ccc1OC(=O)c1cccs1,2.3211000000000004
+187929,Modify the molecule CN(C)C(=O)Nc1cccc(C[NH2+]C(C2CC2)C2CC2)c1 to decrease its LogP value.,CN(C)C(=O)Nc1cccc(C[NH2+]C(C2CC2)C2CC2)c1,2.0321
+194398,Modify the molecule CN(C)S(=O)(=O)c1cccc(NC(=O)[C@H]2CC(=O)N(c3cccc4ccccc34)C2)c1 to have a higher LogP value.,CN(C)S(=O)(=O)c1cccc(NC(=O)[C@H]2CC(=O)N(c3cccc4ccccc34)C2)c1,3.0817000000000014
+76082,Modify the molecule Cc1nc(-c2ccc(C)c(-n3cc(C(=O)Nc4ccc(C)c(Cl)c4)c(C)n3)c2)no1 to increase its LogP value.,Cc1nc(-c2ccc(C)c(-n3cc(C(=O)Nc4ccc(C)c(Cl)c4)c(C)n3)c2)no1,5.061680000000004
+216859,Please optimize the molecule Cc1cc(Cl)ccc1NC(=O)[C@H](C)Sc1nnc(C2CC2)s1 to have a lower LogP value.,Cc1cc(Cl)ccc1NC(=O)[C@H](C)Sc1nnc(C2CC2)s1,4.496620000000002
+165426,Please optimize the molecule Cn1c(=O)cc(NCCCN2CCOCC2)n(Cc2ccc(F)cc2F)c1=O to have a lower LogP value.,Cn1c(=O)cc(NCCCN2CCOCC2)n(Cc2ccc(F)cc2F)c1=O,1.0077
+74012,Modify the molecule COC(=O)C1C(C)=NC2=C(C(=O)CCC2)[C@@H]1c1ccc(OCc2ccccc2)c(OC)c1 to decrease its LogP value.,COC(=O)C1C(C)=NC2=C(C(=O)CCC2)[C@@H]1c1ccc(OCc2ccccc2)c(OC)c1,4.628600000000004
+155172,Please modify the molecule CCc1cc(C(=O)NC[C@@H](c2ccc(OC)cc2)[NH+](C)C)sc1C to decrease its LogP value.,CCc1cc(C(=O)NC[C@@H](c2ccc(OC)cc2)[NH+](C)C)sc1C,2.2431200000000002
+19530,Please modify the molecule CCOCCN(C)Cc1ccc(C)s1 to decrease its LogP value.,CCOCCN(C)Cc1ccc(C)s1,2.524820000000001
+69042,Please modify the molecule Cc1[nH]c2ccc(F)cc2c1CC(=O)N[C@H]1CCS(=O)(=O)C1 to increase its LogP value.,Cc1[nH]c2ccc(F)cc2c1CC(=O)N[C@H]1CCS(=O)(=O)C1,1.4612200000000002
+76849,Modify the molecule N#C[C@@H](C(=O)CC[C@H]1CCCO1)c1ccc(F)cn1 to have a higher LogP value.,N#C[C@@H](C(=O)CC[C@H]1CCCO1)c1ccc(F)cn1,2.35618
+117917,Please optimize the molecule CCN1C(=O)[C@H]2C=CC=C[C@@H]2NC1=S to have a lower LogP value.,CCN1C(=O)[C@H]2C=CC=C[C@@H]2NC1=S,0.8338000000000001
+132789,Please modify the molecule O=C(c1cc(=O)[nH]c([O-])n1)N1CCc2[nH]nc(-c3ccc(F)c(F)c3)c2C1 to increase its LogP value.,O=C(c1cc(=O)[nH]c([O-])n1)N1CCc2[nH]nc(-c3ccc(F)c(F)c3)c2C1,0.7102999999999995
+27899,Please modify the molecule CC[S@@](=O)[C@@H]1CCCC[C@@H]1NC(=O)c1nc(-c2ccco2)sc1C to decrease its LogP value.,CC[S@@](=O)[C@@H]1CCCC[C@@H]1NC(=O)c1nc(-c2ccco2)sc1C,3.5211200000000016
+155737,Please modify the molecule Cc1nc(-c2csc(S(=O)(=O)N3CCC[C@@H](C(=O)NCCC(C)C)C3)c2)no1 to increase its LogP value.,Cc1nc(-c2csc(S(=O)(=O)N3CCC[C@@H](C(=O)NCCC(C)C)C3)c2)no1,2.6695200000000012
+113239,Modify the molecule CCc1ccccc1-n1c(CCl)nc2c(CC)nn(C)c21 to increase its LogP value.,CCc1ccccc1-n1c(CCl)nc2c(CC)nn(C)c21,3.622600000000002
+158685,Please modify the molecule CCC[C@@H](O)c1ccn(Cc2cncn2C(C)C)c1 to decrease its LogP value.,CCC[C@@H](O)c1ccn(Cc2cncn2C(C)C)c1,3.1473000000000013
+226795,Optimize the molecule CCCn1nnc2cc(C(=O)Nc3cccc(SC)c3)ccc21 to have a higher LogP value.,CCCn1nnc2cc(C(=O)Nc3cccc(SC)c3)ccc21,3.815500000000002
+46559,Modify the molecule O=C([C@@H]1CC(=O)N(C2CCCC2)C1)N1CCC(NS(=O)(=O)c2ccc(Cl)cc2)CC1 to have a higher LogP value.,O=C([C@@H]1CC(=O)N(C2CCCC2)C1)N1CCC(NS(=O)(=O)c2ccc(Cl)cc2)CC1,2.4004000000000003
+210681,Modify the molecule O=C(NCCC(F)(F)F)Nc1ccc(F)cc1Br to have a lower LogP value.,O=C(NCCC(F)(F)F)Nc1ccc(F)cc1Br,3.6621000000000015
+95720,Please optimize the molecule C[C@@H]1C[NH+]2CCC[C@@H]2CN1C(=O)Cc1ccc(C[NH3+])cc1 to have a lower LogP value.,C[C@@H]1C[NH+]2CCC[C@@H]2CN1C(=O)Cc1ccc(C[NH3+])cc1,-0.7509999999999952
+30178,Optimize the molecule O=C(NCC[C@H]1CCCO1)c1ccc(Cl)cc1O to have a lower LogP value.,O=C(NCC[C@H]1CCCO1)c1ccc(Cl)cc1O,2.3445000000000005
+12800,Modify the molecule Cc1c(C(=O)Nc2ccc3c(c2)COC3)cccc1[N+](=O)[O-] to increase its LogP value.,Cc1c(C(=O)Nc2ccc3c(c2)COC3)cccc1[N+](=O)[O-],3.1857200000000017
+72633,Please optimize the molecule CCCN1C(=O)C2(OCCCO2)c2cccc(C)c21 to have a higher LogP value.,CCCN1C(=O)C2(OCCCO2)c2cccc(C)c21,2.3413200000000005
+157114,Modify the molecule C=C(C)[C@](C)(C#CC[NH+](CC)CC)OCCC#N to have a lower LogP value.,C=C(C)[C@](C)(C#CC[NH+](CC)CC)OCCC#N,1.1795799999999999
+84790,Optimize the molecule C[C@H](CC(=O)N(C)Cc1nccs1)NC(=O)c1ccccc1 to have a lower LogP value.,C[C@H](CC(=O)N(C)Cc1nccs1)NC(=O)c1ccccc1,2.3101000000000003
+76597,Please modify the molecule CCC(CC)N1C(=O)[C@@H](C(C)(C)C)NC(=O)[C@H]1[C@H](C)CC to decrease its LogP value.,CCC(CC)N1C(=O)[C@@H](C(C)(C)C)NC(=O)[C@H]1[C@H](C)CC,2.9628000000000014
+197149,Please optimize the molecule NS(=O)(=O)c1ccc(CCNc2ccc(C(F)(F)F)cc2[N+](=O)[O-])cc1 to have a higher LogP value.,NS(=O)(=O)c1ccc(CCNc2ccc(C(F)(F)F)cc2[N+](=O)[O-])cc1,2.9156000000000004
+69426,Modify the molecule CC[C@@H]1COCCN1Cc1ccccc1OCc1cccnc1 to decrease its LogP value.,CC[C@@H]1COCCN1Cc1ccccc1OCc1cccnc1,3.2714000000000016
+153633,Modify the molecule C[C@@H]1CCCCN1C(=O)Cn1cnc2onc(-c3ccc(Cl)cc3)c2c1=O to decrease its LogP value.,C[C@@H]1CCCCN1C(=O)Cn1cnc2onc(-c3ccc(Cl)cc3)c2c1=O,3.105900000000002
+159707,Modify the molecule COc1ccc(-c2cc(=O)[nH]c(N3CC[NH+](Cc4ccccc4)CC3)n2)cc1 to increase its LogP value.,COc1ccc(-c2cc(=O)[nH]c(N3CC[NH+](Cc4ccccc4)CC3)n2)cc1,1.3505999999999996
+15428,Modify the molecule COc1cccc(NC(=O)c2cccc(S(=O)(=O)N3CCCCC3)c2)c1 to decrease its LogP value.,COc1cccc(NC(=O)c2cccc(S(=O)(=O)N3CCCCC3)c2)c1,3.1221000000000014
+188946,Please optimize the molecule CCC(C)(C)NC(=O)c1ccc(NCC(=O)OC)cc1Cl to have a higher LogP value.,CCC(C)(C)NC(=O)c1ccc(NCC(=O)OC)cc1Cl,2.843300000000001
+52481,Please optimize the molecule Cc1ccn2/c(=N/C(=O)[C@@H]3CC=CCC3)[nH]nc2c1 to have a higher LogP value.,Cc1ccn2/c(=N/C(=O)[C@@H]3CC=CCC3)[nH]nc2c1,1.7544199999999999
+43828,Modify the molecule O=C(CNC(=O)C1CC1)NC1=NN=C(C2=CC[C@@H](Br)S2)C1 to have a higher LogP value.,O=C(CNC(=O)C1CC1)NC1=NN=C(C2=CC[C@@H](Br)S2)C1,1.528800000000001
+109661,Modify the molecule O=C(CN1c2ccccc2NC2=C(C(=O)CCC2)[C@@H]1c1ccco1)NC1CCCC1 to have a lower LogP value.,O=C(CN1c2ccccc2NC2=C(C(=O)CCC2)[C@@H]1c1ccco1)NC1CCCC1,4.318700000000003
+132673,Please optimize the molecule O=C(Cc1ccc(Cl)cc1)NCc1csc(C2CC2)n1 to have a lower LogP value.,O=C(Cc1ccc(Cl)cc1)NCc1csc(C2CC2)n1,3.5328000000000017
+36559,Optimize the molecule O=C(Nc1ccc2c(c1)N(C(=O)C1CCCC1)CC2)c1ccc2ccccc2n1 to have a higher LogP value.,O=C(Nc1ccc2c(c1)N(C(=O)C1CCCC1)CC2)c1ccc2ccccc2n1,4.566400000000004
+7934,Please modify the molecule CCN(C)S(=O)(=O)c1c(C)nn(Cc2ccc(C(F)(F)F)cc2)c1C to increase its LogP value.,CCN(C)S(=O)(=O)c1c(C)nn(Cc2ccc(C(F)(F)F)cc2)c1C,3.207440000000002
+83410,Modify the molecule Cc1nc(C2CCCC2)sc1/C([O-])=C(\C#N)C(=O)NC1CCCC1 to decrease its LogP value.,Cc1nc(C2CCCC2)sc1/C([O-])=C(\C#N)C(=O)NC1CCCC1,2.762900000000001
+177930,Modify the molecule CCC[NH2+]C/C(=C\[C@H](C)CC)CC to increase its LogP value.,CCC[NH2+]C/C(=C\[C@H](C)CC)CC,2.3423
+85925,Modify the molecule COc1cccc(NC(=O)CNc2cc(Cl)cc(Cl)c2)c1 to decrease its LogP value.,COc1cccc(NC(=O)CNc2cc(Cl)cc(Cl)c2)c1,4.052600000000002
+10112,Please modify the molecule CCc1c(C(=O)N2CCN(S(=O)(=O)N(C)C)CC2)cnn1-c1ccc(F)cc1 to increase its LogP value.,CCc1c(C(=O)N2CCN(S(=O)(=O)N(C)C)CC2)cnn1-c1ccc(F)cc1,1.1380000000000003
+146889,Modify the molecule Brc1ccc(C[NH2+]Cc2ccccc2CN2CCOCC2)cc1 to have a lower LogP value.,Brc1ccc(C[NH2+]Cc2ccccc2CN2CCOCC2)cc1,2.544900000000001
+184583,Modify the molecule COc1ccc([C@H](O)CNC(=O)N[C@H]2CCCc3ccc(F)cc32)cc1 to have a higher LogP value.,COc1ccc([C@H](O)CNC(=O)N[C@H]2CCCc3ccc(F)cc32)cc1,3.244500000000002
+83621,Please optimize the molecule C#CCOc1ccc(NC(=O)[C@H]2CCCN(C(=O)NCC(C)C)C2)cc1 to have a higher LogP value.,C#CCOc1ccc(NC(=O)[C@H]2CCCN(C(=O)NCC(C)C)C2)cc1,2.7147000000000006
+49007,Modify the molecule Cc1cccc([C@@H]2CCCN2C(=O)Nc2cccnc2Cl)c1 to have a higher LogP value.,Cc1cccc([C@@H]2CCCN2C(=O)Nc2cccnc2Cl)c1,4.412420000000003
+14594,Please modify the molecule CC(C)[C@H](NC(=O)[C@H]1CS[C@H]2c3ccccc3C(=O)N12)C(=O)NC1CCCCCC1 to decrease its LogP value.,CC(C)[C@H](NC(=O)[C@H]1CS[C@H]2c3ccccc3C(=O)N12)C(=O)NC1CCCCCC1,3.236200000000001
+61201,Modify the molecule C[C@H](CC#N)N(C)C(=O)N1Cc2[nH+]c[nH]c2C[C@@H]1C(=O)[O-] to decrease its LogP value.,C[C@H](CC#N)N(C)C(=O)N1Cc2[nH+]c[nH]c2C[C@@H]1C(=O)[O-],-1.3406199999999986
+182698,Please optimize the molecule C[C@@H](CCl)CS(=O)(=O)N[C@H](C)c1ccccc1F to have a lower LogP value.,C[C@@H](CCl)CS(=O)(=O)N[C@H](C)c1ccccc1F,2.681000000000001
+85862,Please modify the molecule CCNC(=O)N1C[C@@H](C)C[C@@H]([NH3+])C1 to decrease its LogP value.,CCNC(=O)N1C[C@@H](C)C[C@@H]([NH3+])C1,-0.33179999999999876
+172136,Modify the molecule Cc1cc(-c2nn3c(-c4cc(Cl)cc(Cl)c4)nnc3s2)on1 to have a lower LogP value.,Cc1cc(-c2nn3c(-c4cc(Cl)cc(Cl)c4)nnc3s2)on1,4.123020000000001
+56168,Modify the molecule COc1ccc([C@@H]2N=N/C(=[NH+]/C(=O)Nc3ccccc3)S2)cc1 to decrease its LogP value.,COc1ccc([C@@H]2N=N/C(=[NH+]/C(=O)Nc3ccccc3)S2)cc1,2.5615000000000006
+3826,Please modify the molecule COc1ccc(F)cc1NC(=O)C(=O)NCc1cc(Br)cs1 to decrease its LogP value.,COc1ccc(F)cc1NC(=O)C(=O)NCc1cc(Br)cs1,2.9132000000000007
+148861,Modify the molecule Cc1ccc(CN2C(=O)c3ccccc3[C@@H]2c2c(C)n(C)c3ccccc23)o1 to decrease its LogP value.,Cc1ccc(CN2C(=O)c3ccccc3[C@@H]2c2c(C)n(C)c3ccccc23)o1,5.133540000000004
+38172,Modify the molecule CN(CC1CC[NH+](C)CC1)C(=O)c1ccc(F)c(Br)c1 to increase its LogP value.,CN(CC1CC[NH+](C)CC1)C(=O)c1ccc(F)c(Br)c1,1.5849
+142010,Modify the molecule Cc1ccc2oc(=O)c(CC(=O)c3ccc(F)cc3)nc2c1 to have a lower LogP value.,Cc1ccc2oc(=O)c(CC(=O)c3ccc(F)cc3)nc2c1,3.060920000000001
+235798,Optimize the molecule C[C@@H](NC(=O)[C@@H]1C[C@@H]1c1ccccc1Br)c1cccnc1 to have a higher LogP value.,C[C@@H](NC(=O)[C@@H]1C[C@@H]1c1ccccc1Br)c1cccnc1,3.825000000000003
+36338,Please optimize the molecule Cc1cccc(Oc2ccc(NC(=O)C(=O)N[C@H](C)CO)cc2)c1 to have a higher LogP value.,Cc1cccc(Oc2ccc(NC(=O)C(=O)N[C@H](C)CO)cc2)c1,2.2228199999999996
+138761,Optimize the molecule NC(=O)[C@@H]1CCC[NH+]1[C@@H](C(=O)[O-])c1c[nH]c2cc(OCc3ccccc3)ccc12 to have a lower LogP value.,NC(=O)[C@@H]1CCC[NH+]1[C@@H](C(=O)[O-])c1c[nH]c2cc(OCc3ccccc3)ccc12,0.07050000000000223
+168906,Please optimize the molecule NC(=O)[C@@H](c1cccc(Cl)c1)c1ncc(C(F)(F)F)cc1Cl to have a higher LogP value.,NC(=O)[C@@H](c1cccc(Cl)c1)c1ncc(C(F)(F)F)cc1Cl,4.024400000000001
+211566,Please optimize the molecule Cc1nc2n(n1)CCC[C@H]2[NH2+][C@@H]1CCC[C@@H]1c1ccc(F)cc1 to have a higher LogP value.,Cc1nc2n(n1)CCC[C@H]2[NH2+][C@@H]1CCC[C@@H]1c1ccc(F)cc1,2.4602200000000005
+66837,Please modify the molecule Cc1ccc(C(=O)N2CCC[C@H](C(=O)NCc3nnc4n3CCC4)C2)cc1 to decrease its LogP value.,Cc1ccc(C(=O)N2CCC[C@H](C(=O)NCc3nnc4n3CCC4)C2)cc1,1.701319999999999
+108069,Modify the molecule Oc1ccccc1C1OCCO1 to have a lower LogP value.,Oc1ccccc1C1OCCO1,1.4376
+173284,Modify the molecule CN1CCC([NH+](C)CCN(C)CC(=O)N[C@@H]2CCOc3ccccc32)CC1 to decrease its LogP value.,CN1CCC([NH+](C)CCN(C)CC(=O)N[C@@H]2CCOc3ccccc32)CC1,0.1671000000000049
+519,Modify the molecule COc1ccc(Cn2ccc3nc(N4CCN(c5ccccc5)CC4)ncc3c2=O)cc1 to have a higher LogP value.,COc1ccc(Cn2ccc3nc(N4CCN(c5ccccc5)CC4)ncc3c2=O)cc1,3.1750000000000016
+217295,Optimize the molecule C=CC(=O)Nc1cc(NC(=O)c2cn(C)nc2CC)ccc1F to have a lower LogP value.,C=CC(=O)Nc1cc(NC(=O)c2cn(C)nc2CC)ccc1F,2.4984
+11948,Please modify the molecule CCN(C(=O)[C@H]1[C@H](C=C(C)C)C1(C)C)[C@H]1CCS(=O)(=O)C1 to increase its LogP value.,CCN(C(=O)[C@H]1[C@H](C=C(C)C)C1(C)C)[C@H]1CCS(=O)(=O)C1,2.2604000000000006
+141684,Please modify the molecule C[NH+]1CCN(C(=O)CC2CCN(c3ncnc4nc(N)ccc34)CC2)CC1 to decrease its LogP value.,C[NH+]1CCN(C(=O)CC2CCN(c3ncnc4nc(N)ccc34)CC2)CC1,-0.42959999999999576
+196283,Optimize the molecule CCn1nc(C(=O)NCCc2ccc(C)o2)c(=O)c2cc(F)ccc21 to have a lower LogP value.,CCn1nc(C(=O)NCCc2ccc(C)o2)c(=O)c2cc(F)ccc21,2.4294200000000004
+94315,Optimize the molecule Cc1cccc([C@@H]2CCCN2C(=O)NCc2nnc3n2CCC3)c1C to have a higher LogP value.,Cc1cccc([C@@H]2CCCN2C(=O)NCc2nnc3n2CCC3)c1C,2.8878400000000015
+121725,Modify the molecule CC[C@H](C)NC(=O)Nc1cc(S(=O)(=O)N2CCCCC2)ccc1C to increase its LogP value.,CC[C@H](C)NC(=O)Nc1cc(S(=O)(=O)N2CCCCC2)ccc1C,3.089620000000002
+155064,Modify the molecule O=C(c1cccs1)C(O)O to have a lower LogP value.,O=C(c1cccs1)C(O)O,0.24149999999999988
+28743,Please modify the molecule COC(=O)c1occc1CSc1nnc2sc3ccccc3n12 to increase its LogP value.,COC(=O)c1occc1CSc1nnc2sc3ccccc3n12,3.6159000000000026
+239413,Please modify the molecule Cc1cc(C)c2c(c1)=[NH+][C@@H](C(=O)NCc1ccccc1)C=2 to decrease its LogP value.,Cc1cc(C)c2c(c1)=[NH+][C@@H](C(=O)NCc1ccccc1)C=2,-0.5172599999999961
+78468,Please optimize the molecule O=C(Cl)C1=Cc2ccccc2CC1=O to have a higher LogP value.,O=C(Cl)C1=Cc2ccccc2CC1=O,1.9605999999999995
+44848,Please optimize the molecule Cc1ccsc1C[NH2+][C@@H]1CCC[C@H](C(F)(F)F)C1 to have a lower LogP value.,Cc1ccsc1C[NH2+][C@@H]1CCC[C@H](C(F)(F)F)C1,3.2410200000000016
+244953,Please modify the molecule N#C/C(=C/c1ccc(Cl)cc1)c1nc2ccccc2s1 to decrease its LogP value.,N#C/C(=C/c1ccc(Cl)cc1)c1nc2ccccc2s1,5.013880000000003
+171162,Please optimize the molecule CC1=[NH+]C(=S)[C@H]([N+](=O)[O-])N1 to have a lower LogP value.,CC1=[NH+]C(=S)[C@H]([N+](=O)[O-])N1,-1.9811999999999994
+170742,Please optimize the molecule O=C(/C=C/c1cccs1)N1CCCSC[C@@H]1C[NH+]1CCCCC1 to have a higher LogP value.,O=C(/C=C/c1cccs1)N1CCCSC[C@@H]1C[NH+]1CCCCC1,2.1642
+38247,Modify the molecule CC[C@](C)(CCO)NC(=O)N[C@H]1CCCC[C@@H]1OC1CCCC1 to increase its LogP value.,CC[C@](C)(CCO)NC(=O)N[C@H]1CCCC[C@@H]1OC1CCCC1,3.1071000000000017
+87473,Modify the molecule Cc1cc(C)cc(N(C)CC2(CO)COC2)c1 to have a lower LogP value.,Cc1cc(C)cc(N(C)CC2(CO)COC2)c1,1.7485399999999998
+152234,Modify the molecule O=C(NC[C@H](c1cccs1)[NH+]1CCCC1)c1cccc(NC(=O)[C@@H]2CCCO2)c1 to decrease its LogP value.,O=C(NC[C@H](c1cccs1)[NH+]1CCCC1)c1cccc(NC(=O)[C@@H]2CCCO2)c1,2.015399999999999
+101254,Please modify the molecule COC1CCN(C(=O)NCCC2=CCCCC2)CC1 to decrease its LogP value.,COC1CCN(C(=O)NCCC2=CCCCC2)CC1,2.697300000000001
+46806,Modify the molecule CCS(=O)(=O)CCN(C)C(=O)[C@H](C)Oc1ccc(Cl)c(Cl)c1 to have a higher LogP value.,CCS(=O)(=O)CCN(C)C(=O)[C@H](C)Oc1ccc(Cl)c(Cl)c1,2.6538000000000013
+41480,Please optimize the molecule CC(C)c1cccc(NC(=O)N2CCC(NC(=O)CC3CCCC3)CC2)c1 to have a higher LogP value.,CC(C)c1cccc(NC(=O)N2CCC(NC(=O)CC3CCCC3)CC2)c1,4.502800000000003
+112425,Please modify the molecule C[C@H]1[NH2+]CC[C@@H]1C(=O)NC12CC3CC(CC(C3)C1)C2 to decrease its LogP value.,C[C@H]1[NH2+]CC[C@@H]1C(=O)NC12CC3CC(CC(C3)C1)C2,1.0431999999999997
+115725,Optimize the molecule CN(Cc1nc(C(F)(F)F)cs1)C(=O)c1ccccc1Cl to have a higher LogP value.,CN(Cc1nc(C(F)(F)F)cs1)C(=O)c1ccccc1Cl,4.087500000000002
+136001,Modify the molecule Cc1c(C)c(C)c(S(=O)(=O)N2CCC(C(=O)NCCC[NH+]3CCCC3)CC2)c(C)c1C to increase its LogP value.,Cc1c(C)c(C)c(S(=O)(=O)N2CCC(C(=O)NCCC[NH+]3CCCC3)CC2)c(C)c1C,1.8144000000000018
+164609,Optimize the molecule NC(=O)[C@@H]1[C@@H]2C(=O)N(Cc3ccccc3)C(=O)[C@@H]2[C@H]2c3ccccc3C=CN21 to have a higher LogP value.,NC(=O)[C@@H]1[C@@H]2C(=O)N(Cc3ccccc3)C(=O)[C@@H]2[C@H]2c3ccccc3C=CN21,1.6828999999999994
+90795,Optimize the molecule COCCN(Cc1cccnc1)C(=O)N[C@@H]1C[C@@H]1C1CCCCC1 to have a lower LogP value.,COCCN(Cc1cccnc1)C(=O)N[C@@H]1C[C@@H]1C1CCCCC1,3.208400000000002
+1727,Modify the molecule C[C@@H]1C[C@H]1C(=O)N1CCC(O)(Cn2cnc3cc(Cl)ccc3c2=O)CC1 to have a lower LogP value.,C[C@@H]1C[C@H]1C(=O)N1CCC(O)(Cn2cnc3cc(Cl)ccc3c2=O)CC1,2.0593999999999992
+192758,Optimize the molecule Cc1cc(C)n(-c2ccccc2NC(=O)N(C)[C@@H](C)CS(C)(=O)=O)n1 to have a lower LogP value.,Cc1cc(C)n(-c2ccccc2NC(=O)N(C)[C@@H](C)CS(C)(=O)=O)n1,2.3859400000000006
+74529,Please modify the molecule [NH3+][C@@H]1CCC[C@H]1CCN1CCCC1=O to decrease its LogP value.,[NH3+][C@@H]1CCC[C@H]1CCN1CCCC1=O,0.40949999999999953
+174278,Please modify the molecule Cc1cc(NC[C@@H]2COCCO2)ccc1[N+](=O)[O-] to increase its LogP value.,Cc1cc(NC[C@@H]2COCCO2)ccc1[N+](=O)[O-],1.7305199999999998
+87273,Please modify the molecule CNC(=O)C[NH2+]Cc1ccc(OC)cc1 to increase its LogP value.,CNC(=O)C[NH2+]Cc1ccc(OC)cc1,-0.4953999999999985
+122367,Modify the molecule COc1cc(-c2nnc3s/c(=C/c4ccc(Cl)cc4)c(=O)n23)cc(OC)c1OC to have a lower LogP value.,COc1cc(-c2nnc3s/c(=C/c4ccc(Cl)cc4)c(=O)n23)cc(OC)c1OC,3.044900000000002
+173940,Modify the molecule CN(C)C(=O)c1cc([C@@H]2CCN(C(=O)c3ccccc3-c3ccccc3)C2)nc2ccccc12 to have a higher LogP value.,CN(C)C(=O)c1cc([C@@H]2CCN(C(=O)c3ccccc3-c3ccccc3)C2)nc2ccccc12,5.233300000000005
+91542,Modify the molecule COc1ccc(OC)c(C[NH2+]Cc2cc(OC)c3c(c2)OCCO3)c1 to increase its LogP value.,COc1ccc(OC)c(C[NH2+]Cc2cc(OC)c3c(c2)OCCO3)c1,1.7471999999999994
+24073,Modify the molecule Cc1ccc(Cn2cc(C(=O)c3ccc(F)cc3)c(=O)c3cc(F)ccc32)cc1 to have a higher LogP value.,Cc1ccc(Cn2cc(C(=O)c3ccc(F)cc3)c(=O)c3cc(F)ccc32)cc1,4.867420000000004
+70628,Modify the molecule CC[C@](C)(CO)Nc1nc2ccc(F)cn2n1 to increase its LogP value.,CC[C@](C)(CO)Nc1nc2ccc(F)cn2n1,1.4412999999999996
+118864,Please optimize the molecule Cc1ccccc1NS(=O)(=O)c1ccc2c(c1)oc(=O)n2C to have a higher LogP value.,Cc1ccccc1NS(=O)(=O)c1ccc2c(c1)oc(=O)n2C,2.2407200000000005
+103102,Please modify the molecule Cc1n[nH]cc1C(=O)NNC(=O)C[NH+]1CCC[C@H]1C to decrease its LogP value.,Cc1n[nH]cc1C(=O)NNC(=O)C[NH+]1CCC[C@H]1C,-1.4536799999999979
+130107,Optimize the molecule C[C@H](c1ccc(F)cc1)n1c(Cn2ncc3ccccc3c2=O)n[nH]c1=S to have a lower LogP value.,C[C@H](c1ccc(F)cc1)n1c(Cn2ncc3ccccc3c2=O)n[nH]c1=S,3.4472900000000015
+53730,Please modify the molecule COc1ccc2c(C)nc(N(C)CC[NH+]3CCCC[C@@H]3C)nc2c1 to increase its LogP value.,COc1ccc2c(C)nc(N(C)CC[NH+]3CCCC[C@@H]3C)nc2c1,1.8403199999999995
+237683,Optimize the molecule CN(Cc1ccccn1)C(=O)[C@@H]1CCCN1C(=O)c1ccccn1 to have a higher LogP value.,CN(Cc1ccccn1)C(=O)[C@@H]1CCCN1C(=O)c1ccccn1,1.7397999999999998
+26686,Modify the molecule C[C@@H]1CCCC[C@H]1NC(=O)C(=O)Nc1nnc(-c2cccc(Cl)c2)s1 to decrease its LogP value.,C[C@@H]1CCCC[C@H]1NC(=O)C(=O)Nc1nnc(-c2cccc(Cl)c2)s1,3.491900000000001
+245174,Please optimize the molecule CC[C@@]1(COC)CC(=O)NC(=O)[C@@H]1CC(C)C to have a lower LogP value.,CC[C@@]1(COC)CC(=O)NC(=O)[C@@H]1CC(C)C,1.7379999999999995
+125458,Modify the molecule CC[NH+]1CCC[C@H]1CN(C)c1ccc(C(C)=O)cc1F to decrease its LogP value.,CC[NH+]1CCC[C@H]1CN(C)c1ccc(C(C)=O)cc1F,1.5317000000000005
+123474,Optimize the molecule CC[NH2+]Cc1cccc2c1ccn2C[C@H]1CN(C)CCO1 to have a lower LogP value.,CC[NH2+]Cc1cccc2c1ccn2C[C@H]1CN(C)CCO1,1.0551999999999997
+134028,Optimize the molecule [NH3+]CC[C@@H]1CCC[NH+](Cc2ccc(C3CC3)cc2)C1 to have a lower LogP value.,[NH3+]CC[C@@H]1CCC[NH+](Cc2ccc(C3CC3)cc2)C1,0.9909000000000001
+161393,Modify the molecule O=C(NCCNC(=O)C1CC1)NCc1ccc(C(F)(F)F)cc1 to increase its LogP value.,O=C(NCCNC(=O)C1CC1)NCc1ccc(C(F)(F)F)cc1,2.0308
+116515,Modify the molecule COc1ccc(Nc2cc(N)nc(-c3ccc(F)cc3)n2)c(OC)c1 to have a higher LogP value.,COc1ccc(Nc2cc(N)nc(-c3ccc(F)cc3)n2)c(OC)c1,3.625700000000001
+139944,Modify the molecule CCn1ncc(C2=NS(=O)(=O)N(C)C(C(=O)Nc3ccc(C)c(C)c3)=C2)c1C to decrease its LogP value.,CCn1ncc(C2=NS(=O)(=O)N(C)C(C(=O)Nc3ccc(C)c(C)c3)=C2)c1C,2.3301600000000002
+19664,Modify the molecule Cc1ccc(NC(=O)c2cn(C)nc2S(=O)(=O)N2CCN(c3cccc(Cl)c3)CC2)cc1 to increase its LogP value.,Cc1ccc(NC(=O)c2cn(C)nc2S(=O)(=O)N2CCN(c3cccc(Cl)c3)CC2)cc1,3.145120000000002
+171544,Modify the molecule CCOCCC(=O)NCc1sccc1CC to increase its LogP value.,CCOCCC(=O)NCc1sccc1CC,2.3533
+222813,Modify the molecule C=CCNc1oc(-c2ccccc2OC)nc1S(=O)(=O)c1ccc2c(c1)OCCO2 to have a higher LogP value.,C=CCNc1oc(-c2ccccc2OC)nc1S(=O)(=O)c1ccc2c(c1)OCCO2,3.552100000000002
+142218,Optimize the molecule COc1ncc(Cl)c(NCc2cccc(-c3nc[nH]n3)c2)n1 to have a higher LogP value.,COc1ncc(Cl)c(NCc2cccc(-c3nc[nH]n3)c2)n1,2.5358
+89641,Please modify the molecule CCN1C=C(C(=O)OCc2ccc(F)cc2)C(C)=NS1(=O)=O to increase its LogP value.,CCN1C=C(C(=O)OCc2ccc(F)cc2)C(C)=NS1(=O)=O,1.794
+187362,Modify the molecule C[C@@H]([NH3+])c1cc(F)ccc1SC[C@@H](O)CO to have a lower LogP value.,C[C@@H]([NH3+])c1cc(F)ccc1SC[C@@H](O)CO,0.5739000000000003
+104952,Please modify the molecule COc1ccc(Br)c(C(=O)N2CCN(C)c3nc4ccccc4nc32)c1 to increase its LogP value.,COc1ccc(Br)c(C(=O)N2CCN(C)c3nc4ccccc4nc32)c1,3.4975000000000023
+68902,Please optimize the molecule O=C(NOCCc1ccccc1)Nc1ccc([N+](=O)[O-])cc1 to have a lower LogP value.,O=C(NOCCc1ccccc1)Nc1ccc([N+](=O)[O-])cc1,2.890600000000001
+160275,Modify the molecule CN(C)C(=O)c1ccccc1NC(=S)NC(=O)C1CCCCC1 to decrease its LogP value.,CN(C)C(=O)c1ccccc1NC(=S)NC(=O)C1CCCCC1,2.7817000000000016
+221169,Please modify the molecule Cc1cc(Cl)ccc1NC(=O)c1ccc(Br)cc1N to increase its LogP value.,Cc1cc(Cl)ccc1NC(=O)c1ccc(Br)cc1N,4.245420000000002
+85113,Modify the molecule Cc1ccc(-n2c(S[C@@H]3CCOC3=O)nc3ccccc3c2=O)cc1F to have a lower LogP value.,Cc1ccc(-n2c(S[C@@H]3CCOC3=O)nc3ccccc3c2=O)cc1F,3.240820000000002
+69329,Please optimize the molecule CC[NH2+]Cc1cnn(-c2ccc(Cl)c(F)c2)c1C(F)(F)F to have a higher LogP value.,CC[NH2+]Cc1cnn(-c2ccc(Cl)c(F)c2)c1C(F)(F)F,2.7669000000000015
+132129,Modify the molecule C[C@H](C(=O)NC1C(C)(C)C1(C)C)N1CC[NH2+]CC1 to decrease its LogP value.,C[C@H](C(=O)NC1C(C)(C)C1(C)C)N1CC[NH2+]CC1,-0.1952999999999978
+199584,Modify the molecule CCC[C@H]1C[C@H]1NC(=O)Cn1cnc2ccc(Br)cc2c1=O to have a lower LogP value.,CCC[C@H]1C[C@H]1NC(=O)Cn1cnc2ccc(Br)cc2c1=O,2.4638
+130740,Modify the molecule Cc1cccc(-n2nnnc2S[C@@H](C)C(=O)N2CCCC2)c1 to increase its LogP value.,Cc1cccc(-n2nnnc2S[C@@H](C)C(=O)N2CCCC2)c1,2.07372
+209061,Optimize the molecule O=C(Cn1nc(-c2ccco2)c2sc(N3CCCCC3)nc2c1=O)c1ccccc1 to have a lower LogP value.,O=C(Cn1nc(-c2ccco2)c2sc(N3CCCCC3)nc2c1=O)c1ccccc1,3.986200000000003
+11477,Optimize the molecule C[NH+](C)CCN(Cc1cccnc1)C(=O)c1cc2cccc(Cl)c2o1 to have a higher LogP value.,C[NH+](C)CCN(Cc1cccnc1)C(=O)c1cc2cccc(Cl)c2o1,2.2681000000000004
+64251,Please optimize the molecule O=C(N[C@H]1CCCc2occc21)c1ccc(-c2ccccc2)[nH]c1=O to have a lower LogP value.,O=C(N[C@H]1CCCc2occc21)c1ccc(-c2ccccc2)[nH]c1=O,3.4423000000000012
+198010,Modify the molecule N#Cc1ccc(Cl)cc1S(=O)(=O)N1CCOc2ccccc21 to have a lower LogP value.,N#Cc1ccc(Cl)cc1S(=O)(=O)N1CCOc2ccccc21,2.799380000000001
+3023,Please modify the molecule O=C(NCc1ccc(N2CCOCC2)[nH+]c1)c1csc2c1CCCC2 to increase its LogP value.,O=C(NCc1ccc(N2CCOCC2)[nH+]c1)c1csc2c1CCCC2,2.2076000000000002
+80473,Optimize the molecule C[C@H]1CN(C(=O)c2cccc3c2O[C@H](C)C(=O)N3)C[C@H]1[NH+](C)C to have a lower LogP value.,C[C@H]1CN(C(=O)c2cccc3c2O[C@H](C)C(=O)N3)C[C@H]1[NH+](C)C,0.011000000000001675
+218854,Please modify the molecule O=C1CN2CSC[C@H]2C(=O)N1Cc1ccccc1 to increase its LogP value.,O=C1CN2CSC[C@H]2C(=O)N1Cc1ccccc1,0.9302999999999999
+153692,Modify the molecule Cc1ccc([C@H](C)NC(=O)c2cc3ccccc3oc2=O)cc1C to decrease its LogP value.,Cc1ccc([C@H](C)NC(=O)c2cc3ccccc3oc2=O)cc1C,3.9008400000000023
+189765,Modify the molecule CON(C)C(=O)c1ccc(NC(=O)[C@H]2CCCS2)cc1 to have a lower LogP value.,CON(C)C(=O)c1ccc(NC(=O)[C@H]2CCCS2)cc1,2.1540999999999997
+83123,Please modify the molecule CCc1cc(=O)n(CC(=O)Nc2cc(F)ccc2F)c(N2CCOCC2)n1 to increase its LogP value.,CCc1cc(=O)n(CC(=O)Nc2cc(F)ccc2F)c(N2CCOCC2)n1,1.5592000000000001
+109466,Modify the molecule CC(C)n1ncc2cc(C(=O)NCCNC(=O)c3ccco3)cnc21 to have a higher LogP value.,CC(C)n1ncc2cc(C(=O)NCCNC(=O)c3ccco3)cnc21,1.765
+71399,Please modify the molecule CC[NH+](Cc1ccccc1N1CCN(C(C)=O)CC1)[C@@H](C)c1ccc(F)cc1 to decrease its LogP value.,CC[NH+](Cc1ccccc1N1CCN(C(C)=O)CC1)[C@@H](C)c1ccc(F)cc1,2.6602000000000006
+244192,Optimize the molecule O=C(c1ccc(Cl)cc1)C1CC[NH+](Cc2ccccn2)CC1 to have a lower LogP value.,O=C(c1ccc(Cl)cc1)C1CC[NH+](Cc2ccccn2)CC1,2.4128000000000007
+76569,Please optimize the molecule COc1ccc(N)c2nc(C)c(C)nc12 to have a higher LogP value.,COc1ccc(N)c2nc(C)c(C)nc12,1.8374399999999997
+199837,Optimize the molecule CC1=C2C(=O)N=C(CS[C@H](C)C(=O)NCc3ccc4c(c3)OCCO4)N=C2S[C@@H]1C to have a lower LogP value.,CC1=C2C(=O)N=C(CS[C@H](C)C(=O)NCc3ccc4c(c3)OCCO4)N=C2S[C@@H]1C,2.984700000000002
+117533,Please modify the molecule CC(=O)NC12C[C@H]3C[C@@H](C1)CC(C(=O)Nc1ccc4ccccc4n1)(C3)C2 to increase its LogP value.,CC(=O)NC12C[C@H]3C[C@@H](C1)CC(C(=O)Nc1ccc4ccccc4n1)(C3)C2,3.6484000000000023
+234161,Please modify the molecule CCS(=O)(=O)[N-]c1ccc([C@@H](C)[NH2+][C@@H]2CCN(C(C)=O)C2)cc1 to increase its LogP value.,CCS(=O)(=O)[N-]c1ccc([C@@H](C)[NH2+][C@@H]2CCN(C(C)=O)C2)cc1,1.2866999999999997
+194016,Please optimize the molecule COc1ccc([C@H](Cl)[C@]2(C)CCCO2)c(Br)c1 to have a lower LogP value.,COc1ccc([C@H](Cl)[C@]2(C)CCCO2)c(Br)c1,4.306700000000003
+48187,Modify the molecule Cc1nc2ccc3nc(NC(=O)CN4C(=O)CCC4=O)sc3c2s1 to have a higher LogP value.,Cc1nc2ccc3nc(NC(=O)CN4C(=O)CCC4=O)sc3c2s1,2.30192
+86120,Please optimize the molecule CCOc1cccc(C(=O)Cc2[nH+]ccn2C)c1 to have a higher LogP value.,CCOc1cccc(C(=O)Cc2[nH+]ccn2C)c1,1.6633
+238515,Optimize the molecule C[C@H]1CCCN(C(=O)NCCOCC(F)(F)F)CC1 to have a higher LogP value.,C[C@H]1CCCN(C(=O)NCCOCC(F)(F)F)CC1,2.3969000000000005
+123177,Please optimize the molecule CC[NH+](CC)[C@](C)(CC)[C@@H](O)Cc1ccc2c(c1)CCC2 to have a lower LogP value.,CC[NH+](CC)[C@](C)(CC)[C@@H](O)Cc1ccc2c(c1)CCC2,2.1721000000000004
+48822,Modify the molecule COc1ccc(C(=O)N2CCC[C@H]2CC(C)=O)cc1O to decrease its LogP value.,COc1ccc(C(=O)N2CCC[C@H]2CC(C)=O)cc1O,1.9845000000000002
+175371,Please optimize the molecule COC(=O)[C@H](O)C1CC[NH+](CC2=Cc3ccccc3OC2)CC1 to have a higher LogP value.,COC(=O)[C@H](O)C1CC[NH+](CC2=Cc3ccccc3OC2)CC1,0.29120000000000146
+130765,Modify the molecule CC(C)(C)OC(=O)N1CCC[C@@H]1COc1ccnc(Cl)n1 to have a lower LogP value.,CC(C)(C)OC(=O)N1CCC[C@@H]1COc1ccnc(Cl)n1,2.9083000000000014
+200885,Please modify the molecule CC(=C1C(=O)c2ccccc2C1=O)N1CC[C@H]2CCCN2C1 to decrease its LogP value.,CC(=C1C(=O)c2ccccc2C1=O)N1CC[C@H]2CCCN2C1,2.467200000000001
+214276,Please optimize the molecule O=[N+]([O-])c1c(Nc2ccccc2F)ncnc1N1CCCCC1 to have a lower LogP value.,O=[N+]([O-])c1c(Nc2ccccc2F)ncnc1N1CCCCC1,3.2578000000000014
+74139,Please modify the molecule COc1cccc(-c2cn[nH]c2C2CCN(Cc3[nH+]ccn3C)CC2)c1 to decrease its LogP value.,COc1cccc(-c2cn[nH]c2C2CCN(Cc3[nH+]ccn3C)CC2)c1,2.6175000000000006
+207734,Modify the molecule C[C@@]12C(=O)N(C3CC[NH+](Cc4ccccc4)CC3)CC(=O)N1CCc1c2[nH]c2ccccc12 to have a higher LogP value.,C[C@@]12C(=O)N(C3CC[NH+](Cc4ccccc4)CC3)CC(=O)N1CCc1c2[nH]c2ccccc12,1.8575000000000008
+143622,Modify the molecule C[C@H]1COCCN1C(=O)CCCc1cc(F)ccc1F to decrease its LogP value.,C[C@H]1COCCN1C(=O)CCCc1cc(F)ccc1F,2.5348000000000006
+239539,Modify the molecule CCC(=O)N1CCN(Cc2cccn2C)CC1 to decrease its LogP value.,CCC(=O)N1CCN(Cc2cccn2C)CC1,1.0793
+103533,Optimize the molecule COc1cc(Cl)c(C)cc1N1C(=O)C[C@H](N2CCN(c3ccc(O)cc3)CC2)C1=O to have a higher LogP value.,COc1cc(Cl)c(C)cc1N1C(=O)C[C@H](N2CCN(c3ccc(O)cc3)CC2)C1=O,2.816720000000001
+4755,Modify the molecule O=C([O-])c1cc(C2CC2)nc2c(-c3ccc(Cl)cc3)cnn12 to decrease its LogP value.,O=C([O-])c1cc(C2CC2)nc2c(-c3ccc(Cl)cc3)cnn12,2.2905999999999995
+135237,Please modify the molecule CC(=O)OCC(=O)C1=c2ccccc2=[NH+][C@H]1c1ccccc1 to increase its LogP value.,CC(=O)OCC(=O)C1=c2ccccc2=[NH+][C@H]1c1ccccc1,-0.5753999999999988
+60996,Optimize the molecule N#CCNC(=O)CCS(=O)(=O)Cc1ccccc1 to have a lower LogP value.,N#CCNC(=O)CCS(=O)(=O)Cc1ccccc1,0.6312799999999994
+116,Optimize the molecule Cc1nnccc1C(=O)N[C@H](C)c1ccc(Cl)s1 to have a lower LogP value.,Cc1nnccc1C(=O)N[C@H](C)c1ccc(Cl)s1,2.990920000000001
+110016,Optimize the molecule O=C(NNc1cccc(F)c1F)Nc1ccc(N2CCCC2)[nH+]c1 to have a higher LogP value.,O=C(NNc1cccc(F)c1F)Nc1ccc(N2CCCC2)[nH+]c1,2.5277000000000003
+54095,Please modify the molecule Cc1cc(C)n(CCCOc2ccc(S(C)(=O)=O)cc2)n1 to increase its LogP value.,Cc1cc(C)n(CCCOc2ccc(S(C)(=O)=O)cc2)n1,2.3725400000000008
+200778,Optimize the molecule C[C@@H]1Cc2ccccc2N1C(=O)C[C@H](O)c1ccc(Cl)cc1 to have a lower LogP value.,C[C@@H]1Cc2ccccc2N1C(=O)C[C@H](O)c1ccc(Cl)cc1,3.7413000000000034
+180338,Modify the molecule CCOC(=O)CN1CCN(c2ccccc2OC)C(=O)[C@H]1C to have a lower LogP value.,CCOC(=O)CN1CCN(c2ccccc2OC)C(=O)[C@H]1C,1.2953999999999999
+8980,Please modify the molecule O=C([O-])CC1(NC(=O)C2(c3ccccc3)CC2)CCC1 to increase its LogP value.,O=C([O-])CC1(NC(=O)C2(c3ccccc3)CC2)CCC1,0.8971000000000007
+189413,Modify the molecule C[C@H](SCc1cnn(-c2ccccc2)c1)C(=O)Nc1ccc2c(c1)CCC2 to have a higher LogP value.,C[C@H](SCc1cnn(-c2ccccc2)c1)C(=O)Nc1ccc2c(c1)CCC2,4.621400000000004
+45972,Modify the molecule C[NH+]1CCN(Cc2ccc(CNC(=O)c3cn4cccnc4n3)cc2)CC1 to increase its LogP value.,C[NH+]1CCN(Cc2ccc(CNC(=O)c3cn4cccnc4n3)cc2)CC1,-0.010399999999997744
+172375,Please modify the molecule Cc1nsc(N[C@@H]2CC[NH+](C3CC3)C2)c1C#N to decrease its LogP value.,Cc1nsc(N[C@@H]2CC[NH+](C3CC3)C2)c1C#N,0.5547
+136445,Please modify the molecule Cc1ccc(NC(=O)C(=O)NCCc2ccccc2)c(C)c1 to increase its LogP value.,Cc1ccc(NC(=O)C(=O)NCCc2ccccc2)c(C)c1,2.6008400000000007
+10165,Please modify the molecule COc1c(Br)cc(Br)cc1/C=C/C(=O)Nc1ccc2c(c1)C(=O)N(C)C2=O to decrease its LogP value.,COc1c(Br)cc(Br)cc1/C=C/C(=O)Nc1ccc2c(c1)C(=O)N(C)C2=O,4.097900000000004
+22291,Modify the molecule Cc1noc(C)c1CCC(=O)[C@H](C#N)c1nc2sc3c(c2c(=O)[nH]1)CCCC3 to have a lower LogP value.,Cc1noc(C)c1CCC(=O)[C@H](C#N)c1nc2sc3c(c2c(=O)[nH]1)CCCC3,3.2773200000000013
+14711,Modify the molecule O=C(N/N=C\c1cc(Br)c(Br)s1)c1ccncc1 to increase its LogP value.,O=C(N/N=C\c1cc(Br)c(Br)s1)c1ccncc1,3.4320000000000013
+95124,Please optimize the molecule Cc1ccc(CNC(=O)NC[C@H](c2ccco2)[NH+](C)C)cn1 to have a higher LogP value.,Cc1ccc(CNC(=O)NC[C@H](c2ccco2)[NH+](C)C)cn1,0.6680200000000001
+104840,Optimize the molecule Cc1ccc(O)c(C(=O)N(C)C[C@@H]2CC[NH+](C)C2)c1 to have a higher LogP value.,Cc1ccc(O)c(C(=O)N(C)C[C@@H]2CC[NH+](C)C2)c1,0.30722000000000055
+132436,Please modify the molecule CCOCc1ccc(CNC(=O)N(C)[C@@H]2CCC[C@@H](C)C2)cc1 to increase its LogP value.,CCOCc1ccc(CNC(=O)N(C)[C@@H]2CCC[C@@H](C)C2)cc1,3.9432000000000036
+1123,Optimize the molecule Cc1ccc([N+](=O)[O-])cc1C(=O)Nc1cnc(-c2ccccc2)s1 to have a higher LogP value.,Cc1ccc([N+](=O)[O-])cc1C(=O)Nc1cnc(-c2ccccc2)s1,4.279020000000002
+12511,Modify the molecule COc1ccc([C@H](C)NC(=O)Cc2ccc(C)cc2)cc1 to decrease its LogP value.,COc1ccc([C@H](C)NC(=O)Cc2ccc(C)cc2)cc1,3.4235200000000026
+193152,Please modify the molecule Cc1nn(C)c(C)c1NC(=O)[C@H](C)[NH+]1CCCSCC1 to decrease its LogP value.,Cc1nn(C)c(C)c1NC(=O)[C@H](C)[NH+]1CCCSCC1,0.3857400000000011
+248807,Please modify the molecule O=c1c2c(-c3ccc(F)cc3)csc2[nH]c(=S)n1Cc1ccccc1 to decrease its LogP value.,O=c1c2c(-c3ccc(F)cc3)csc2[nH]c(=S)n1Cc1ccccc1,4.974990000000003
+44982,Modify the molecule Cc1ccc(OCC2(O)CCCC2)c(C[NH2+]C2CC2)n1 to decrease its LogP value.,Cc1ccc(OCC2(O)CCCC2)c(C[NH2+]C2CC2)n1,1.2997199999999998
+137474,Please optimize the molecule CC[NH2+][C@H](C)c1ccc(Oc2cccc(Cl)c2)c(F)c1 to have a higher LogP value.,CC[NH2+][C@H](C)c1ccc(Oc2cccc(Cl)c2)c(F)c1,3.915700000000003
+148242,Please optimize the molecule CN(Cc1cnn(-c2ccccc2)c1)C(=O)c1ccccc1O to have a lower LogP value.,CN(Cc1cnn(-c2ccccc2)c1)C(=O)c1ccccc1O,2.8501000000000016
+71805,Modify the molecule CCN(CC(=O)NC)C(=O)c1ccncc1/C=C/C(=O)[O-] to have a higher LogP value.,CCN(CC(=O)NC)C(=O)c1ccncc1/C=C/C(=O)[O-],-0.9471999999999996
+27968,Please modify the molecule C[NH2+][C@]1(C(=O)[O-])CCC[C@@H]1CCn1nc(C)c(Cl)c1C to increase its LogP value.,C[NH2+][C@]1(C(=O)[O-])CCC[C@@H]1CCn1nc(C)c(Cl)c1C,0.02544000000000035
+67360,Please modify the molecule Cc1ncsc1[C@@H]1N[C@H](C(=O)[O-])C(C)(C)S1 to decrease its LogP value.,Cc1ncsc1[C@@H]1N[C@H](C(=O)[O-])C(C)(C)S1,0.6836199999999999
+116332,Modify the molecule CC(C)(CNc1cc(OC(F)F)c(F)cc1N)S(C)(=O)=O to have a higher LogP value.,CC(C)(CNc1cc(OC(F)F)c(F)cc1N)S(C)(=O)=O,2.2443999999999997
+106537,Please modify the molecule Cc1ccc(N2CCCC2=O)c(C(=O)Nc2cccc(-n3cnnn3)c2)c1 to decrease its LogP value.,Cc1ccc(N2CCCC2=O)c(C(=O)Nc2cccc(-n3cnnn3)c2)c1,2.3498200000000002
+165339,Please optimize the molecule CC1=C(C(=O)Nc2ccccc2F)[C@H](c2ccccc2F)NC(=O)N1 to have a lower LogP value.,CC1=C(C(=O)Nc2ccccc2F)[C@H](c2ccccc2F)NC(=O)N1,3.2314000000000007
+87133,Modify the molecule O=C(Nc1ncccc1Cl)c1ccc(Cl)cc1 to decrease its LogP value.,O=C(Nc1ncccc1Cl)c1ccc(Cl)cc1,3.6407000000000016
+132253,Please optimize the molecule C[C@H](NC(=O)NCC(C)(C)c1ccc2c(c1)OCO2)C1CC1 to have a lower LogP value.,C[C@H](NC(=O)NCC(C)(C)c1ccc2c(c1)OCO2)C1CC1,2.7906000000000013
+235271,Please modify the molecule Cc1cc(C)c2nc(NC(=O)[C@@H]3CCCO3)sc2c1 to decrease its LogP value.,Cc1cc(C)c2nc(NC(=O)[C@@H]3CCCO3)sc2c1,3.0306400000000018
+190289,Modify the molecule C/C(=N\NC(=O)[C@H]1C=C(c2ccccc2)N=N1)c1ccc(Cl)c(Cl)c1 to decrease its LogP value.,C/C(=N\NC(=O)[C@H]1C=C(c2ccccc2)N=N1)c1ccc(Cl)c(Cl)c1,4.709100000000003
+165694,Please optimize the molecule O=C(NC[C@H]1COC2(CCCCC2)O1)c1ccc(Cl)cc1 to have a lower LogP value.,O=C(NC[C@H]1COC2(CCCCC2)O1)c1ccc(Cl)cc1,3.145600000000001
+100714,Please optimize the molecule Cc1cc(NC(=O)N(C)C[C@@H](O)C2CC2)ccc1Br to have a higher LogP value.,Cc1cc(NC(=O)N(C)C[C@@H](O)C2CC2)ccc1Br,2.9921200000000017
+46760,Modify the molecule CCC[NH2+][C@H](c1cccc(OC)c1)c1cscc1Br to decrease its LogP value.,CCC[NH2+][C@H](c1cccc(OC)c1)c1cscc1Br,3.5820000000000016
+61631,Please modify the molecule CC[NH+](CC)[C@@H](CN/C=C1/C(=O)NC(=O)c2ccccc21)c1ccsc1 to increase its LogP value.,CC[NH+](CC)[C@@H](CN/C=C1/C(=O)NC(=O)c2ccccc21)c1ccsc1,1.6146000000000003
+144151,Please modify the molecule CC1=C(C(=O)[O-])[C@H](c2ccc(Cl)cc2)n2ncnc2N1 to decrease its LogP value.,CC1=C(C(=O)[O-])[C@H](c2ccc(Cl)cc2)n2ncnc2N1,0.9702999999999999
+218147,Modify the molecule C[C@@H]1CCC[C@](CCSc2ccccc2)(C(=O)[O-])C1 to have a lower LogP value.,C[C@@H]1CCC[C@](CCSc2ccccc2)(C(=O)[O-])C1,3.1152000000000015
+164447,Optimize the molecule C[C@H]1C[C@@H](C)CN(C(=O)N[C@@H]2CCCc3c2cnn3C)C1 to have a higher LogP value.,C[C@H]1C[C@@H](C)CN(C(=O)N[C@@H]2CCCc3c2cnn3C)C1,2.4850000000000003
+107682,Please modify the molecule CCCCOc1ccc(C(=O)NCc2ccsc2)cc1 to decrease its LogP value.,CCCCOc1ccc(C(=O)NCc2ccsc2)cc1,3.857000000000003
+169777,Please modify the molecule Fc1ccc(Br)c(CNC[C@H]2COc3ccccc32)c1 to increase its LogP value.,Fc1ccc(Br)c(CNC[C@H]2COc3ccccc32)c1,3.8540000000000028
+88806,Optimize the molecule C[NH+]1CCC(CN(CCc2ccccc2)C(=O)[C@@H]2CC=CCC2)CC1 to have a lower LogP value.,C[NH+]1CCC(CN(CCc2ccccc2)C(=O)[C@@H]2CC=CCC2)CC1,2.3387000000000002
+170893,Modify the molecule Cc1ccc(CNC(=O)[C@@H]2CC(=O)N(CCN3CCOCC3)C2)cc1 to have a higher LogP value.,Cc1ccc(CNC(=O)[C@@H]2CC(=O)N(CCN3CCOCC3)C2)cc1,0.7919200000000008
+214850,Modify the molecule C[C@H]1Cc2cc(S(N)(=O)=O)ccc2N1Cc1nnsc1Cl to have a higher LogP value.,C[C@H]1Cc2cc(S(N)(=O)=O)ccc2N1Cc1nnsc1Cl,1.7900999999999998
+67173,Optimize the molecule O=C(NCCc1c[nH]c2ccccc12)c1cn(CCC2CCCCC2)nn1 to have a higher LogP value.,O=C(NCCc1c[nH]c2ccccc12)c1cn(CCC2CCCCC2)nn1,3.702300000000003
+120772,Please modify the molecule CCn1c(-c2ccccc2)nn(C[NH+]2CCC[C@@H](C)C2)c1=S to decrease its LogP value.,CCn1c(-c2ccccc2)nn(C[NH+]2CCC[C@@H](C)C2)c1=S,2.373290000000001
+140361,Optimize the molecule O=C(Nc1ccc(F)cc1OCC(F)F)[C@@H]1CC(=O)N(C2CCCC2)C1 to have a higher LogP value.,O=C(Nc1ccc(F)cc1OCC(F)F)[C@@H]1CC(=O)N(C2CCCC2)C1,3.199200000000002
+36650,Modify the molecule C[C@@H]1CCN(C(=O)Nc2ccccc2N2CCCCCC2)C[C@@H]1O to increase its LogP value.,C[C@@H]1CCN(C(=O)Nc2ccccc2N2CCCCCC2)C[C@@H]1O,3.3016000000000028
+193321,Please modify the molecule COc1ccccc1C(=O)CCc1cc(C)cc(C)c1 to decrease its LogP value.,COc1ccccc1C(=O)CCc1cc(C)cc(C)c1,4.127540000000003
+29014,Modify the molecule C[C@H]1CCN(C(=O)c2ccc3nncn3c2)[C@@H](C)C1 to decrease its LogP value.,C[C@H]1CCN(C(=O)c2ccc3nncn3c2)[C@@H](C)C1,1.9899
+214806,Modify the molecule O[C@@H]1CCCC[C@H]1[NH2+]Cc1ccc(F)cc1 to decrease its LogP value.,O[C@@H]1CCCC[C@H]1[NH2+]Cc1ccc(F)cc1,1.1925999999999994
+116230,Modify the molecule COc1cccc(C(=O)NCc2c(C)nn(-c3ccccc3)c2C)c1 to increase its LogP value.,COc1cccc(C(=O)NCc2c(C)nn(-c3ccccc3)c2C)c1,3.427740000000002
+47924,Please optimize the molecule O[C@H](COCc1ccccc1)CSc1ccc2ccccc2n1 to have a higher LogP value.,O[C@H](COCc1ccccc1)CSc1ccc2ccccc2n1,3.904600000000003
+199964,Modify the molecule COC(=O)C[C@@H]1SC2=C(C(=O)Nc3cccc(C)c3)[C@@H](c3cccc(F)c3)C(C#N)=C(N)N2C1=O to increase its LogP value.,COC(=O)C[C@@H]1SC2=C(C(=O)Nc3cccc(C)c3)[C@@H](c3cccc(F)c3)C(C#N)=C(N)N2C1=O,3.2826000000000004
+90416,Modify the molecule CC1=NC(=O)[C@H](CC(=O)[O-])CS1 to increase its LogP value.,CC1=NC(=O)[C@H](CC(=O)[O-])CS1,-0.5655999999999999
+40051,Optimize the molecule Cn1nnnc1SCC(=O)N1CCO[C@H](c2cccs2)C1 to have a higher LogP value.,Cn1nnnc1SCC(=O)N1CCO[C@H](c2cccs2)C1,0.9637999999999997
+95668,Please optimize the molecule CC(C)(C)NC(=O)Cn1cc(C(N)=O)c(-c2ccccc2)n1 to have a lower LogP value.,CC(C)(C)NC(=O)Cn1cc(C(N)=O)c(-c2ccccc2)n1,1.5636999999999996
+25070,Modify the molecule CCCN1C(=O)N=C(N)[C@@H]1c1ccc(F)cc1F to decrease its LogP value.,CCCN1C(=O)N=C(N)[C@@H]1c1ccc(F)cc1F,2.2087000000000003
+16127,Please optimize the molecule O=[N+]([O-])c1ccc(CN2CC[NH+](Cc3cccnc3)CC2)cc1 to have a lower LogP value.,O=[N+]([O-])c1ccc(CN2CC[NH+](Cc3cccnc3)CC2)cc1,0.8904999999999994
+197742,Modify the molecule C[C@H]1CNc2cc(Br)cnc2N1 to increase its LogP value.,C[C@H]1CNc2cc(Br)cnc2N1,2.07
+90299,Please optimize the molecule O=C([O-])c1cccnc1C(=O)Nc1ccc(Cl)cn1 to have a higher LogP value.,O=C([O-])c1cccnc1C(=O)Nc1ccc(Cl)cn1,0.7457999999999998
+101042,Modify the molecule O=C(NC[C@]1(c2ccccc2)CCCOCC1)c1ccc(F)cc1Cl to decrease its LogP value.,O=C(NC[C@]1(c2ccccc2)CCCOCC1)c1ccc(F)cc1Cl,4.347400000000004
+138176,Please modify the molecule CSc1ccccc1C[NH+]1CCC(CNC(=O)NCc2ccccc2)CC1 to decrease its LogP value.,CSc1ccccc1C[NH+]1CCC(CNC(=O)NCc2ccccc2)CC1,2.7028000000000008
+93568,Please modify the molecule CCOC(=O)C1(C)CC[NH+]([C@H](C)C(=O)Nc2cc(Cl)ccc2C)CC1 to decrease its LogP value.,CCOC(=O)C1(C)CC[NH+]([C@H](C)C(=O)Nc2cc(Cl)ccc2C)CC1,2.2235199999999997
+21229,Please modify the molecule Cc1c(Cl)cccc1-n1nc(C)c2c(C)cc(OCC(=O)Nc3ccc4c(c3)OCCO4)nc21 to decrease its LogP value.,Cc1c(Cl)cccc1-n1nc(C)c2c(C)cc(OCC(=O)Nc3ccc4c(c3)OCCO4)nc21,4.787860000000004
+68761,Please modify the molecule COc1ccc(NS(=O)(=O)c2ccc(F)c(C)c2)cc1 to increase its LogP value.,COc1ccc(NS(=O)(=O)c2ccc(F)c(C)c2)cc1,2.9435200000000012
+176736,Optimize the molecule O=C(/C=C/c1ccncc1)NCCc1nc2ccc(F)cc2[nH]1 to have a higher LogP value.,O=C(/C=C/c1ccncc1)NCCc1nc2ccc(F)cc2[nH]1,2.4691
+16439,Optimize the molecule COc1cc(C(=O)NCc2cnn(C)c2)cc(OC)c1OC(F)F to have a lower LogP value.,COc1cc(C(=O)NCc2cnn(C)c2)cc(OC)c1OC(F)F,1.9686999999999997
+118238,Modify the molecule COc1ccc(S(N)(=O)=O)cc1C(=O)NC[C@@H](C)c1ccsc1 to increase its LogP value.,COc1ccc(S(N)(=O)=O)cc1C(=O)NC[C@@H](C)c1ccsc1,1.9376000000000002
+89254,Optimize the molecule CS(=O)(=O)N1CCC[C@@H](Nc2cc(-c3ccccc3)nc3ncnn23)C1 to have a lower LogP value.,CS(=O)(=O)N1CCC[C@@H](Nc2cc(-c3ccccc3)nc3ncnn23)C1,1.6271999999999998
+210467,Modify the molecule O=C(Nc1nnc(S(=O)(=O)NCc2ccccc2)s1)C1CCCCC1 to have a lower LogP value.,O=C(Nc1nnc(S(=O)(=O)NCc2ccccc2)s1)C1CCCCC1,2.535400000000001
+137318,Optimize the molecule CCOc1cc(C#N)ccc1OCC(=O)Nc1c(Cl)cccc1C(F)(F)F to have a higher LogP value.,CCOc1cc(C#N)ccc1OCC(=O)Nc1c(Cl)cccc1C(F)(F)F,4.646680000000002
+65543,Please modify the molecule CC[C@@H](CO)[NH+]1CCN([C@H](C)C(=O)NC(=O)Nc2ccccc2F)CC1 to decrease its LogP value.,CC[C@@H](CO)[NH+]1CCN([C@H](C)C(=O)NC(=O)Nc2ccccc2F)CC1,-0.166299999999997
+95786,Modify the molecule CC(C)CN1CCO[C@H](CNC(=O)C(=O)Nc2ccccc2C(C)C)C1 to decrease its LogP value.,CC(C)CN1CCO[C@H](CNC(=O)C(=O)Nc2ccccc2C(C)C)C1,2.2215
+161749,Optimize the molecule CCS(=O)(=O)c1ccc(C(=O)Nc2ccc(-c3nc4ccccc4s3)cc2)cc1 to have a higher LogP value.,CCS(=O)(=O)c1ccc(C(=O)Nc2ccc(-c3nc4ccccc4s3)cc2)cc1,5.009200000000004
+94833,Please modify the molecule O=C(NCCN1CC[NH+](Cc2ccccc2)CC1)N1CCC[C@H](CO)C1 to increase its LogP value.,O=C(NCCN1CC[NH+](Cc2ccccc2)CC1)N1CCC[C@H](CO)C1,-0.1989999999999969
+137945,Modify the molecule Cc1cc(C)c2[nH]c(C(=O)N3CC[C@@H](c4ccccc4F)C3)c(C)c2c1 to decrease its LogP value.,Cc1cc(C)c2[nH]c(C(=O)N3CC[C@@H](c4ccccc4F)C3)c(C)c2c1,4.861960000000004
+41875,Please optimize the molecule CC1CCN(c2ccc(CNC(=O)NCCn3cccc3)c[nH+]2)CC1 to have a lower LogP value.,CC1CCN(c2ccc(CNC(=O)NCCn3cccc3)c[nH+]2)CC1,2.0379
+153205,Please modify the molecule CC(=O)N1CCC[C@H]1c1cnccn1 to increase its LogP value.,CC(=O)N1CCC[C@H]1c1cnccn1,1.16
+245358,Please optimize the molecule CC(C)CCn1nc(C(=O)[O-])c2c1CCN(C(=O)[C@@H]1CCc3nn(C)c(=O)n3C1)C2 to have a lower LogP value.,CC(C)CCn1nc(C(=O)[O-])c2c1CCN(C(=O)[C@@H]1CCc3nn(C)c(=O)n3C1)C2,-0.6647999999999976
+207288,Modify the molecule O=C(N[C@H]1CCN(c2ccccc2)C1)N1CCc2cc(F)ccc2C1 to decrease its LogP value.,O=C(N[C@H]1CCN(c2ccccc2)C1)N1CCc2cc(F)ccc2C1,3.1723000000000017
+152005,Please modify the molecule CNC(=O)NCC(=O)N[C@@H]1c2cccc(F)c2CC[C@@H]1C to decrease its LogP value.,CNC(=O)NCC(=O)N[C@@H]1c2cccc(F)c2CC[C@@H]1C,1.4943000000000004
+11697,Optimize the molecule COCCNC(=O)c1cccc(C(=O)OC)c1 to have a lower LogP value.,COCCNC(=O)c1cccc(C(=O)OC)c1,0.8493999999999997
+46000,Modify the molecule C[NH+](C)[C@@H]1CCCN(Cc2ccc([N+](=O)[O-])o2)C1 to increase its LogP value.,C[NH+](C)[C@@H]1CCCN(Cc2ccc([N+](=O)[O-])o2)C1,0.2967000000000011
+106629,Optimize the molecule OC[C@H](Cc1ccc(Cl)cc1)N1CN[C@H](c2ccccc2)[C@H]1c1[nH]cc[nH+]1 to have a higher LogP value.,OC[C@H](Cc1ccc(Cl)cc1)N1CN[C@H](c2ccccc2)[C@H]1c1[nH]cc[nH+]1,2.7309
+249119,Optimize the molecule CC(C)(C)C(=O)Nc1nc2c(s1)C[C@H]1[C@](C)(CC[C@@H](O)[C@@]1(C)CO)[C@@H]2CC(=O)[O-] to have a higher LogP value.,CC(C)(C)C(=O)Nc1nc2c(s1)C[C@H]1[C@](C)(CC[C@@H](O)[C@@]1(C)CO)[C@@H]2CC(=O)[O-],1.6831999999999998
+61368,Please modify the molecule Cc1ccc2c(c1)c(-c1csc(N)n1)c(C)n2C to decrease its LogP value.,Cc1ccc2c(c1)c(-c1csc(N)n1)c(C)n2C,3.500840000000001
+211278,Modify the molecule CN(C)/C=N\C(=O)NN(C)c1ncc(C(F)(F)F)cc1Cl to increase its LogP value.,CN(C)/C=N\C(=O)NN(C)c1ncc(C(F)(F)F)cc1Cl,2.4045000000000005
+7839,Please optimize the molecule Clc1cccc(-c2nnc(Cn3nccc3-c3ccncc3)o2)c1 to have a lower LogP value.,Clc1cccc(-c2nnc(Cn3nccc3-c3ccncc3)o2)c1,3.6968000000000023
+194623,Optimize the molecule Cc1cc(C)cc(OCc2ccc(C(=O)N3CCN(Cc4ccccc4)CC3)o2)c1 to have a lower LogP value.,Cc1cc(C)cc(OCc2ccc(C(=O)N3CCN(Cc4ccccc4)CC3)o2)c1,4.433440000000004
+11189,Modify the molecule Cc1ccc(/C=C/C(=O)NCC2CCC(C(=O)[O-])CC2)s1 to increase its LogP value.,Cc1ccc(/C=C/C(=O)NCC2CCC(C(=O)[O-])CC2)s1,1.7422199999999997
+155789,Please optimize the molecule CCC(CC)NC(=O)N1CCCN(c2ccc(C(F)(F)F)cn2)CC1 to have a lower LogP value.,CCC(CC)NC(=O)N1CCCN(c2ccc(C(F)(F)F)cn2)CC1,3.5107000000000026
+69971,Modify the molecule C(=N/N1CCN(C2c3ccccc3-c3ccccc32)CC1)\c1ccc2c(c1)OCCO2 to increase its LogP value.,C(=N/N1CCN(C2c3ccccc3-c3ccccc32)CC1)\c1ccc2c(c1)OCCO2,4.179300000000003
+82890,Modify the molecule Cc1ccc(-c2cc(C(=O)NNC(=O)c3ccco3)c3ccccc3n2)cc1 to have a lower LogP value.,Cc1ccc(-c2cc(C(=O)NNC(=O)c3ccco3)c3ccccc3n2)cc1,3.878020000000001
+219536,Optimize the molecule Cc1c(CNC(=O)Cn2nc([O-])ccc2=O)cnn1C to have a higher LogP value.,Cc1c(CNC(=O)Cn2nc([O-])ccc2=O)cnn1C,-1.3247799999999992
+209805,Modify the molecule CC[NH+](CCn1cnc2ccsc2c1=O)[C@@H](C)c1ccc(F)cc1 to have a lower LogP value.,CC[NH+](CCn1cnc2ccsc2c1=O)[C@@H](C)c1ccc(F)cc1,2.2631000000000006
+123454,Modify the molecule [NH3+]CCc1cc(-c2cc(F)cc(F)c2)[nH]n1 to increase its LogP value.,[NH3+]CCc1cc(-c2cc(F)cc(F)c2)[nH]n1,1.1393
+56345,Please modify the molecule Cc1ccc(C)c(NC(=S)NC[C@@H](c2cccnc2)N2CCOCC2)c1 to increase its LogP value.,Cc1ccc(C)c(NC(=S)NC[C@@H](c2cccnc2)N2CCOCC2)c1,3.058340000000001
+155596,Optimize the molecule O=C1NC(=O)C(=Cc2ccc(OCc3c(F)cccc3Cl)cc2)C(=O)N1 to have a higher LogP value.,O=C1NC(=O)C(=Cc2ccc(OCc3c(F)cccc3Cl)cc2)C(=O)N1,2.807500000000001
+206505,Optimize the molecule C[NH2+]C[C@@H](C)C(=O)N[C@@H](C)Cn1cccn1 to have a lower LogP value.,C[NH2+]C[C@@H](C)C(=O)N[C@@H](C)Cn1cccn1,-0.7828999999999982
+99365,Please modify the molecule Cc1ccc2[nH]c(C[NH+]3C[C@H]4CC[C@@H]3CN(C(=O)c3cnccn3)C4)c(C)c2c1 to decrease its LogP value.,Cc1ccc2[nH]c(C[NH+]3C[C@H]4CC[C@@H]3CN(C(=O)c3cnccn3)C4)c(C)c2c1,1.8942400000000001
+26154,Modify the molecule C[C@H]1C[C@H](Nc2ccc(SC(F)F)cc2)CS1 to have a lower LogP value.,C[C@H]1C[C@H](Nc2ccc(SC(F)F)cc2)CS1,4.307200000000003
+208735,Please modify the molecule C[C@H]1CCc2c(sc(NC(=O)[C@@H]3CCS(=O)(=O)C3)c2C(=O)c2ccccc2)C1 to decrease its LogP value.,C[C@H]1CCc2c(sc(NC(=O)[C@@H]3CCS(=O)(=O)C3)c2C(=O)c2ccccc2)C1,3.4771000000000027
+10952,Please optimize the molecule N#Cc1cccc(C(=O)N[C@H]2[C@H](O)[C@H](O)C[C@@H]2c2ccc(C(F)(F)F)cc2)c1 to have a lower LogP value.,N#Cc1cccc(C(=O)N[C@H]2[C@H](O)[C@H](O)C[C@@H]2c2ccc(C(F)(F)F)cc2)c1,2.5847800000000003
+244514,Modify the molecule C[C@@H](CCc1ccc2c(c1)OCO2)[NH2+]C[C@@H]1CCCN(c2ncccn2)C1 to have a higher LogP value.,C[C@@H](CCc1ccc2c(c1)OCO2)[NH2+]C[C@@H]1CCCN(c2ncccn2)C1,2.0063999999999993
+232007,Please modify the molecule Cc1nc(C)c(CNC(=O)c2cc(C3CC3)nc3ccc(F)cc23)s1 to increase its LogP value.,Cc1nc(C)c(CNC(=O)c2cc(C3CC3)nc3ccc(F)cc23)s1,4.254640000000004
+179014,Please optimize the molecule O=C(NCc1ccsc1)NCC1CCC(C(=O)[O-])CC1 to have a lower LogP value.,O=C(NCc1ccsc1)NCC1CCC(C(=O)[O-])CC1,1.1036
+120231,Please optimize the molecule CCSc1ccc([C@@H](C)NCc2sc(C)nc2C)cc1 to have a higher LogP value.,CCSc1ccc([C@@H](C)NCc2sc(C)nc2C)cc1,4.722740000000004
+133664,Please optimize the molecule O=C(NCc1cccc(OCC(F)F)n1)[C@@H]1CC(=O)N(c2cn[nH]c2)C1 to have a lower LogP value.,O=C(NCc1cccc(OCC(F)F)n1)[C@@H]1CC(=O)N(c2cn[nH]c2)C1,1.1178999999999997
+156549,Please optimize the molecule Cc1ccccc1NC(=O)[C@@H](C)Oc1ccc2ccc(=O)oc2c1 to have a lower LogP value.,Cc1ccccc1NC(=O)[C@@H](C)Oc1ccc2ccc(=O)oc2c1,3.5074200000000015
+244888,Modify the molecule O=C(NCCCCC1CCCC1)c1nccn2ccnc12 to have a higher LogP value.,O=C(NCCCCC1CCCC1)c1nccn2ccnc12,2.819600000000001
+207735,Optimize the molecule CC[C@H]1CC[C@H]([NH+]2CCC(C(=O)Nc3ccccc3Br)CC2)C1 to have a higher LogP value.,CC[C@H]1CC[C@H]([NH+]2CCC(C(=O)Nc3ccccc3Br)CC2)C1,3.2612000000000014
+248727,Please modify the molecule CC1(C)Cc2cccc(OCc3nccc(N)n3)c2O1 to increase its LogP value.,CC1(C)Cc2cccc(OCc3nccc(N)n3)c2O1,2.3513
+177847,Please modify the molecule CCOC(=O)C(=Cc1cc2ccc(C)cc2nc1Cl)C(=O)OCC to increase its LogP value.,CCOC(=O)C(=Cc1cc2ccc(C)cc2nc1Cl)C(=O)OCC,3.7062200000000036
+25724,Optimize the molecule C[C@H](CO)[C@@H](C)NC(=O)Nc1cc(-c2ccccc2)on1 to have a lower LogP value.,C[C@H](CO)[C@@H](C)NC(=O)Nc1cc(-c2ccccc2)on1,2.4800000000000004
+67400,Please optimize the molecule COC(=O)Cc1nn(-c2ccc(C)cc2)c2c1nnc1nc(-c3ccccc3Cl)nn12 to have a lower LogP value.,COC(=O)Cc1nn(-c2ccc(C)cc2)c2c1nnc1nc(-c3ccccc3Cl)nn12,3.2025200000000016
+196617,Please modify the molecule COC(=O)[C@@H]1C[C@@H](O)CN1CC(=O)N1CCCCCC1 to increase its LogP value.,COC(=O)[C@@H]1C[C@@H](O)CN1CC(=O)N1CCCCCC1,-0.0027999999999999137
+147543,Modify the molecule CC[NH+](CC)CCNC(=O)c1ccc(C)cc1F to decrease its LogP value.,CC[NH+](CC)CCNC(=O)c1ccc(C)cc1F,0.7886199999999999
+161624,Optimize the molecule c1ccc2c(c1)ccc1c3ccccc3oc21 to have a lower LogP value.,c1ccc2c(c1)ccc1c3ccccc3oc21,4.739200000000002
+61119,Modify the molecule Cc1ccccc1-n1c(C)nnc1SCC(=O)NC1CC1 to decrease its LogP value.,Cc1ccccc1-n1c(C)nnc1SCC(=O)NC1CC1,2.2548399999999997
+119393,Modify the molecule COc1cccc(CCCNC(=O)c2c[nH]c3ccc([N+](=O)[O-])cc23)c1 to have a higher LogP value.,COc1cccc(CCCNC(=O)c2c[nH]c3ccc([N+](=O)[O-])cc23)c1,3.447300000000001
+78474,Modify the molecule Cc1ccc(N2CC[C@H](C(=O)N[C@H](c3ncc(C)s3)C3CC3)C2=O)cc1 to decrease its LogP value.,Cc1ccc(N2CC[C@H](C(=O)N[C@H](c3ncc(C)s3)C3CC3)C2=O)cc1,3.380340000000002
+4546,Please modify the molecule O=C(Nc1ccccc1)[C@H]1CCCN(C(=O)c2cccs2)C1 to decrease its LogP value.,O=C(Nc1ccccc1)[C@H]1CCCN(C(=O)c2cccs2)C1,3.2390000000000017
+74627,Modify the molecule Cc1ccc(N2CC[C@@H](NC(=O)CC(C)(C)C)C2=O)cc1C to increase its LogP value.,Cc1ccc(N2CC[C@@H](NC(=O)CC(C)(C)C)C2=O)cc1C,2.961140000000001
+111459,Modify the molecule CCCNC(=O)[C@@H](C)[NH+]1CCCN(S(=O)(=O)c2ccccc2)CC1 to decrease its LogP value.,CCCNC(=O)[C@@H](C)[NH+]1CCCN(S(=O)(=O)c2ccccc2)CC1,-0.11939999999999684
+224014,Modify the molecule COC[C@H]1CC[NH+](Cc2ccc(C(=O)[O-])cn2)C1 to have a higher LogP value.,COC[C@H]1CC[NH+](Cc2ccc(C(=O)[O-])cn2)C1,-1.5036999999999978
+45906,Please modify the molecule COCC[C@H](NC(=O)N1CCN2C(=O)NC[C@H]2C1)C(=O)[O-] to decrease its LogP value.,COCC[C@H](NC(=O)N1CCN2C(=O)NC[C@H]2C1)C(=O)[O-],-2.439599999999996
+202975,Modify the molecule COCc1nc2cc(NC(=O)c3csc(C)n3)ccc2o1 to have a higher LogP value.,COCc1nc2cc(NC(=O)c3csc(C)n3)ccc2o1,2.9914200000000015
+120474,Modify the molecule O=C1N[C@]2(CCOc3ccccc32)C(=O)N1CC(=O)N1CCCSc2ccccc21 to have a higher LogP value.,O=C1N[C@]2(CCOc3ccccc32)C(=O)N1CC(=O)N1CCCSc2ccccc21,2.7452000000000014
+204951,Please optimize the molecule CC(=O)[C@H](C)n1c(CNC(=O)/C=C\c2ccccc2)nc2ccccc21 to have a lower LogP value.,CC(=O)[C@H](C)n1c(CNC(=O)/C=C\c2ccccc2)nc2ccccc21,3.515900000000002
+120341,Modify the molecule COCc1nc(C[NH+]2CCC[C@H](N3CCCC3=O)C2)cs1 to have a higher LogP value.,COCc1nc(C[NH+]2CCC[C@H](N3CCCC3=O)C2)cs1,0.45920000000000116
+4885,Modify the molecule CCOc1ccccc1/C=N/NC(=O)[C@H]1C=C(c2cccc([N+](=O)[O-])c2)N=N1 to decrease its LogP value.,CCOc1ccccc1/C=N/NC(=O)[C@H]1C=C(c2cccc([N+](=O)[O-])c2)N=N1,3.3191000000000015
+108954,Modify the molecule C[C@H](CC(=O)[O-])N1C(=O)CCCC1=O to increase its LogP value.,C[C@H](CC(=O)[O-])N1C(=O)CCCC1=O,-0.946
+234904,Modify the molecule CCN(C(=O)[C@H]1CS[C@@]2(C)CCC(=O)N12)[C@H](C)c1cccc(OC)c1 to have a higher LogP value.,CCN(C(=O)[C@H]1CS[C@@]2(C)CCC(=O)N12)[C@H](C)c1cccc(OC)c1,3.0587000000000018
+221702,Modify the molecule CN(CC[C@H]1CCCC[NH+]1C)C(=O)NCC(C1CC1)C1CC1 to have a higher LogP value.,CN(CC[C@H]1CCCC[NH+]1C)C(=O)NCC(C1CC1)C1CC1,1.5213000000000005
+135290,Please modify the molecule Cc1nc(-c2ccc(NC(=O)c3ccc([N+](=O)[O-])cc3Cl)cc2)cs1 to increase its LogP value.,Cc1nc(-c2ccc(NC(=O)c3ccc([N+](=O)[O-])cc3Cl)cc2)cs1,4.932420000000002
+134560,Please optimize the molecule COc1ccc2c(c1OC)C(=O)N1[C@@H](C(=O)NCc3ccco3)CS[C@@H]21 to have a higher LogP value.,COc1ccc2c(c1OC)C(=O)N1[C@@H](C(=O)NCc3ccco3)CS[C@@H]21,2.183
+3310,Modify the molecule CC[C@H]1CCCN(C(=O)c2cc(C)n(-c3nccs3)c2C)C1 to have a lower LogP value.,CC[C@H]1CCCN(C(=O)c2cc(C)n(-c3nccs3)c2C)C1,3.812840000000003
+23034,Please modify the molecule Cc1cc(F)ccc1NC(=O)C1CCN(S(=O)(=O)c2cccnc2)CC1 to decrease its LogP value.,Cc1cc(F)ccc1NC(=O)C1CCN(S(=O)(=O)c2cccnc2)CC1,2.5685200000000004
+237772,Please optimize the molecule COc1cccc(C(=O)N2CCC3(CC2)Nc2ccc(Cl)cc2-n2cccc23)c1 to have a higher LogP value.,COc1cccc(C(=O)N2CCC3(CC2)Nc2ccc(Cl)cc2-n2cccc23)c1,4.6963000000000035
+134672,Please modify the molecule O=C(NC[C@H]1CC[NH+](Cc2c[nH]cn2)C1)c1cccc2c1NCCC2 to decrease its LogP value.,O=C(NC[C@H]1CC[NH+](Cc2c[nH]cn2)C1)c1cccc2c1NCCC2,0.6026000000000016
+248695,Modify the molecule CNC(=O)c1ccc(OC)c(NC(=O)c2ccc3[nH]c(C)c(C)c3c2)c1 to have a lower LogP value.,CNC(=O)c1ccc(OC)c(NC(=O)c2ccc3[nH]c(C)c(C)c3c2)c1,3.405240000000002
+63788,Modify the molecule Cc1cc(NC(=O)CCN(C)[C@H](c2ccccc2)c2ccc(F)cc2)no1 to increase its LogP value.,Cc1cc(NC(=O)CCN(C)[C@H](c2ccccc2)c2ccc(F)cc2)no1,4.172120000000003
+107664,Optimize the molecule CCOC(=O)c1ccc(S(=O)(=O)N2CCN(C(=O)OCC)CC2)cc1 to have a lower LogP value.,CCOC(=O)c1ccc(S(=O)(=O)N2CCN(C(=O)OCC)CC2)cc1,1.3260999999999998
+83244,Modify the molecule Cn1ccnc1COC(=O)c1ccc(S(=O)(=O)N2CCCc3ccccc32)cc1 to have a lower LogP value.,Cn1ccnc1COC(=O)c1ccc(S(=O)(=O)N2CCCc3ccccc32)cc1,2.9186000000000014
+93991,Optimize the molecule Fc1ccccc1[C@@H]1C[NH2+]CC[C@@H]1c1cccc(Br)c1 to have a higher LogP value.,Fc1ccccc1[C@@H]1C[NH2+]CC[C@@H]1c1cccc(Br)c1,3.4227000000000016
+181496,Please optimize the molecule CC(C)Oc1ccc(NC(=O)N[C@H](C)[C@H]2CCCO2)cc1Cl to have a higher LogP value.,CC(C)Oc1ccc(NC(=O)N[C@H](C)[C@H]2CCCO2)cc1Cl,3.816200000000002
+212402,Modify the molecule COc1cccc(CNC(=O)Nc2ccc3sc(NC(=O)c4ccccc4)nc3c2)c1 to decrease its LogP value.,COc1cccc(CNC(=O)Nc2ccc3sc(NC(=O)c4ccccc4)nc3c2)c1,4.8789000000000025
+108575,Please optimize the molecule CC1(C)C(=O)NC(=O)N1CC(=O)N1CCC[C@H]1c1ccc(F)cc1 to have a lower LogP value.,CC1(C)C(=O)NC(=O)N1CC(=O)N1CCC[C@H]1c1ccc(F)cc1,1.8195999999999994
+112094,Optimize the molecule O=C(Nc1cccnc1)c1ccc2c(n1)NCCS2 to have a higher LogP value.,O=C(Nc1cccnc1)c1ccc2c(n1)NCCS2,2.2465
+176488,Modify the molecule COc1ccc([C@H](C)N[C@H](C)C(=O)N2CCOCC2)c(F)c1 to have a higher LogP value.,COc1ccc([C@H](C)N[C@H](C)C(=O)N2CCOCC2)c(F)c1,1.7322
+14337,Modify the molecule C/C=C/CN(c1ncnc2oc(C)nc12)[C@H](C)CC to have a higher LogP value.,C/C=C/CN(c1ncnc2oc(C)nc12)[C@H](C)CC,3.1072200000000016
+173853,Modify the molecule COC(=O)C1(NC(=O)c2cnccn2)CCCC1 to decrease its LogP value.,COC(=O)C1(NC(=O)c2cnccn2)CCCC1,0.6921999999999993
+189254,Modify the molecule CCS[C@H]1CC[C@H](N(C)C(=O)c2cc(S(=O)(=O)NC)oc2C)C1 to decrease its LogP value.,CCS[C@H]1CC[C@H](N(C)C(=O)c2cc(S(=O)(=O)NC)oc2C)C1,2.2423200000000003
+169676,Please modify the molecule Cn1ccnc1SCC(=O)NC(=O)NCc1ccccc1 to increase its LogP value.,Cn1ccnc1SCC(=O)NC(=O)NCc1ccccc1,1.5381999999999996
+155880,Please modify the molecule C[C@H](C#N)Oc1ccc(C[NH+]2CCC[C@H](N3CCCC3=O)C2)cc1 to decrease its LogP value.,C[C@H](C#N)Oc1ccc(C[NH+]2CCC[C@H](N3CCCC3=O)C2)cc1,1.1471799999999996
+194108,Please modify the molecule CC(C)NS(=O)(=O)c1ccc([C@@H]2CNC(=O)C2)cc1 to increase its LogP value.,CC(C)NS(=O)(=O)c1ccc([C@@H]2CNC(=O)C2)cc1,0.9768
+84446,Modify the molecule N#Cc1ccc(CS(=O)(=O)/N=C(\[O-])c2ccc(Br)s2)cc1 to have a lower LogP value.,N#Cc1ccc(CS(=O)(=O)/N=C(\[O-])c2ccc(Br)s2)cc1,2.01918
+220268,Optimize the molecule Cc1cc(CNc2ncnc3c2CCCC3)no1 to have a lower LogP value.,Cc1cc(CNc2ncnc3c2CCCC3)no1,2.2639200000000006
+215855,Please optimize the molecule O=C(c1ccc(Cl)cn1)[n+]1ccccc1Nc1ccccc1 to have a higher LogP value.,O=C(c1ccc(Cl)cn1)[n+]1ccccc1Nc1ccccc1,3.454600000000001
+150688,Modify the molecule CCc1c(C(=O)COc2ccccc2N2CCC[C@@H](C)C2)[nH]c(C)c1C(C)=O to decrease its LogP value.,CCc1c(C(=O)COc2ccccc2N2CCC[C@@H](C)C2)[nH]c(C)c1C(C)=O,4.586120000000004
+62632,Please modify the molecule CC(C)([NH3+])CS[C@H]1CCOC2(CCSCC2)C1 to decrease its LogP value.,CC(C)([NH3+])CS[C@H]1CCOC2(CCSCC2)C1,2.1849000000000007
+227547,Please optimize the molecule Cc1cccc(C(=O)NNC(=O)c2ccccc2-n2cccc2)c1 to have a higher LogP value.,Cc1cccc(C(=O)NNC(=O)c2ccccc2-n2cccc2)c1,2.860520000000001
+175590,Modify the molecule C[C@@H](CCc1ccccc1F)C(=O)N1CCCN(C(=O)C(C)(C)C)CC1 to have a lower LogP value.,C[C@@H](CCc1ccccc1F)C(=O)N1CCCN(C(=O)C(C)(C)C)CC1,3.501400000000003
+180194,Optimize the molecule C#CC[NH+]1CCC(Nc2cc(OC)cc(OC)c2)CC1 to have a lower LogP value.,C#CC[NH+]1CCC(Nc2cc(OC)cc(OC)c2)CC1,0.7961999999999998
+200781,Optimize the molecule CC[C@H](C)[C@H](O)c1nccc2ccccc12 to have a higher LogP value.,CC[C@H](C)[C@H](O)c1nccc2ccccc12,3.314300000000002
+30046,Please modify the molecule Cn1cnc(CNC(=O)NC2(c3cccc(Br)c3)CCC2)n1 to increase its LogP value.,Cn1cnc(CNC(=O)NC2(c3cccc(Br)c3)CCC2)n1,2.4562
+224182,Modify the molecule CCN(CC(C)(C)O)C1=NS(=O)(=O)c2ccccc21 to have a lower LogP value.,CCN(CC(C)(C)O)C1=NS(=O)(=O)c2ccccc21,1.2283
+11746,Modify the molecule CC(=O)c1ccc(S(=O)(=O)N(Cc2ccccc2)[C@H](C)C2CC2)cc1 to have a higher LogP value.,CC(=O)c1ccc(S(=O)(=O)N(Cc2ccccc2)[C@H](C)C2CC2)cc1,3.878600000000003
+95809,Please modify the molecule Cc1cccc(NC(=O)N2CCc3ccc([N+](=O)[O-])cc3C2)c1Cl to increase its LogP value.,Cc1cccc(NC(=O)N2CCc3ccc([N+](=O)[O-])cc3C2)c1Cl,4.1468200000000035
+19689,Please optimize the molecule C[C@H](Cc1ccccc1)OC(=O)[C@@H]1CCCN(C(=O)c2ccncc2)C1 to have a lower LogP value.,C[C@H](Cc1ccccc1)OC(=O)[C@@H]1CCCN(C(=O)c2ccncc2)C1,3.108200000000002
+82976,Please modify the molecule C[C@@H]1CN(C(=O)C2=NN(c3ccccc3)C(=O)CC2)C(C)(C)CO1 to increase its LogP value.,C[C@@H]1CN(C(=O)C2=NN(c3ccccc3)C(=O)CC2)C(C)(C)CO1,2.1953000000000005
+204480,Modify the molecule O=C(NCc1ccncc1)N1CCN(c2ccc([N+](=O)[O-])cc2)CC1 to have a lower LogP value.,O=C(NCc1ccncc1)N1CCN(c2ccc([N+](=O)[O-])cc2)CC1,2.0216000000000003
+25092,Modify the molecule COc1cccc2c(C)cc(SCC[NH+]3CCCCC3)nc12 to decrease its LogP value.,COc1cccc2c(C)cc(SCC[NH+]3CCCCC3)nc12,2.712720000000001
+97060,Optimize the molecule Cc1nnc([C@@H](C)Sc2nc3ccccc3c(=O)n2-c2ccc(C)c(C)c2)o1 to have a lower LogP value.,Cc1nnc([C@@H](C)Sc2nc3ccccc3c(=O)n2-c2ccc(C)c(C)c2)o1,4.547260000000004
+168232,Modify the molecule C/C(=C\C(=O)c1cccnc1)Nc1ccc(Oc2ccccc2)cc1 to have a lower LogP value.,C/C(=C\C(=O)c1cccnc1)Nc1ccc(Oc2ccccc2)cc1,5.072500000000004
+197934,Modify the molecule CSc1nc(C(=O)N[C@@H](c2nc(C3CC3)no2)C(C)C)c2ccccn12 to decrease its LogP value.,CSc1nc(C(=O)N[C@@H](c2nc(C3CC3)no2)C(C)C)c2ccccn12,3.4437000000000024
+71624,Modify the molecule O=C([O-])c1ccc(F)c([N-]S(=O)(=O)c2cc(Cl)sc2Cl)c1 to decrease its LogP value.,O=C([O-])c1ccc(F)c([N-]S(=O)(=O)c2cc(Cl)sc2Cl)c1,2.951600000000001
+10503,Please modify the molecule COCCN1CCN([C@H]2CCN(c3ccc(Cl)cc3)C2=O)CC1=O to increase its LogP value.,COCCN1CCN([C@H]2CCN(c3ccc(Cl)cc3)C2=O)CC1=O,1.2358999999999996
+188665,Optimize the molecule O=C(N/N=C/c1cccc([N+](=O)[O-])c1)C(=O)Nc1cccc(Br)c1 to have a lower LogP value.,O=C(N/N=C/c1cccc([N+](=O)[O-])c1)C(=O)Nc1cccc(Br)c1,2.4461000000000004
+26562,Modify the molecule Cn1ncc2c(N3CCN(CC(=O)NCc4ccc(F)cc4)CC3)ncnc21 to have a lower LogP value.,Cn1ncc2c(N3CCN(CC(=O)NCc4ccc(F)cc4)CC3)ncnc21,0.9408000000000001
+99110,Modify the molecule COC(=O)c1ccc(C(=O)N[C@H]2C[C@@](C)(OC)C2(C)C)cc1 to have a lower LogP value.,COC(=O)c1ccc(C(=O)N[C@H]2C[C@@](C)(OC)C2(C)C)cc1,2.406600000000001
+53207,Modify the molecule C[C@@H](NC(=O)NC[C@H](O)C1CCOCC1)c1ccccc1C(F)(F)F to have a higher LogP value.,C[C@@H](NC(=O)NC[C@H](O)C1CCOCC1)c1ccccc1C(F)(F)F,2.8531000000000013
+128686,Please modify the molecule COc1ccc(NC(=O)[C@H](C)[NH+]2C[C@H](C)S[C@@H](C)C2)c([N+](=O)[O-])c1 to decrease its LogP value.,COc1ccc(NC(=O)[C@H](C)[NH+]2C[C@H](C)S[C@@H](C)C2)c([N+](=O)[O-])c1,1.3391
+156642,Please optimize the molecule O=C(COc1cccc([N+](=O)[O-])c1)N/N=C/c1ccc(Cl)cc1Cl to have a higher LogP value.,O=C(COc1cccc([N+](=O)[O-])c1)N/N=C/c1ccc(Cl)cc1Cl,3.4307000000000016
+126281,Please modify the molecule CCCC(=CC(=O)[C@H](C#N)c1ccccn1)CCC to decrease its LogP value.,CCCC(=CC(=O)[C@H](C#N)c1ccccn1)CCC,3.784480000000002
+245457,Modify the molecule C[NH2+]Cc1cc(Cl)cc(Cl)c1OC/C(Cl)=C/Cl to have a lower LogP value.,C[NH2+]Cc1cc(Cl)cc(Cl)c1OC/C(Cl)=C/Cl,3.384400000000001
+182324,Please modify the molecule CC1(C)Cc2c(ccc3ccccc23)/C(=C/C(=O)N2CCCCC2)N1 to increase its LogP value.,CC1(C)Cc2c(ccc3ccccc23)/C(=C/C(=O)N2CCCCC2)N1,4.117500000000002
+124262,Optimize the molecule COc1ccc(-c2nnc(SCCS(C)(=O)=O)n2-c2ccccc2)cc1 to have a higher LogP value.,COc1ccc(-c2nnc(SCCS(C)(=O)=O)n2-c2ccccc2)cc1,3.079600000000002
+139301,Modify the molecule CCc1ccc2c(COC(=O)[C@@H]3C[C@@H]3c3ccco3)cc(=O)oc2c1 to have a lower LogP value.,CCc1ccc2c(COC(=O)[C@@H]3C[C@@H]3c3ccco3)cc(=O)oc2c1,3.795300000000003
+148320,Please optimize the molecule [NH3+]CCc1c(-c2ccccc2)nn(-c2ccccc2)c1[O-] to have a lower LogP value.,[NH3+]CCc1c(-c2ccccc2)nn(-c2ccccc2)c1[O-],1.3973
+130038,Modify the molecule [NH3+][C@@H]1CCC[C@@H]([NH+]2CCCCC2)C1 to decrease its LogP value.,[NH3+][C@@H]1CCC[C@@H]([NH+]2CCCCC2)C1,-0.39169999999999927
+176096,Modify the molecule COc1ccc(NC(=O)N2CCOC[C@H]2C2CC2)c(Cl)c1 to increase its LogP value.,COc1ccc(NC(=O)N2CCOC[C@H]2C2CC2)c(Cl)c1,2.9913000000000016
+19332,Modify the molecule Cn1cc(NCCN2CCOCC2)cn1 to have a lower LogP value.,Cn1cc(NCCN2CCOCC2)cn1,0.16420000000000012
+88195,Please optimize the molecule COc1cc(C)c(NCc2cnn(-c3ccccc3)c2)cc1OC to have a lower LogP value.,COc1cc(C)c(NCc2cnn(-c3ccccc3)c2)cc1OC,3.8100200000000024
+239810,Please optimize the molecule CC[C@H]([NH2+][C@@H]1CCCn2nc(C)nc21)c1ccccc1OCC(=O)N(C)C to have a lower LogP value.,CC[C@H]([NH2+][C@@H]1CCCn2nc(C)nc21)c1ccccc1OCC(=O)N(C)C,1.6031199999999992
+207021,Please optimize the molecule N#Cc1ccccc1N/C=C/C(=O)c1ccc(Br)cc1 to have a higher LogP value.,N#Cc1ccccc1N/C=C/C(=O)c1ccc(Br)cc1,4.129280000000002
+75243,Optimize the molecule O=C(NC[C@H]1CCCO1)c1ccccc1NC(=O)C1CC[NH+](Cc2ccccc2)CC1 to have a lower LogP value.,O=C(NC[C@H]1CCCO1)c1ccccc1NC(=O)C1CC[NH+](Cc2ccccc2)CC1,2.029000000000001
+38084,Modify the molecule C[NH2+][C@H](CC(F)(F)F)c1ccc(Br)o1 to have a lower LogP value.,C[NH2+][C@H](CC(F)(F)F)c1ccc(Br)o1,2.2288000000000006
+153008,Optimize the molecule COC(=O)c1ccc(N2CCN(C(=O)Cc3ccsc3)CC2)cc1 to have a lower LogP value.,COC(=O)c1ccc(N2CCN(C(=O)Cc3ccsc3)CC2)cc1,2.426000000000001
+177787,Optimize the molecule CC(=O)N1CC[NH+](C[C@@H](CC(=O)Nc2ccccc2F)C(=O)[O-])CC1 to have a higher LogP value.,CC(=O)N1CC[NH+](C[C@@H](CC(=O)Nc2ccccc2F)C(=O)[O-])CC1,-1.7325999999999968
+55842,Please modify the molecule O=C(NCc1ccccc1F)Nc1ccc(S(=O)(=O)C(F)F)cc1 to increase its LogP value.,O=C(NCc1ccccc1F)Nc1ccc(S(=O)(=O)C(F)F)cc1,3.143700000000001
+118006,Modify the molecule Cc1cc(C)c(OC[C@H](O)Cn2c(C)nc3ccccc32)c(C)c1 to increase its LogP value.,Cc1cc(C)c(OC[C@H](O)Cn2c(C)nc3ccccc32)c(C)c1,3.7098800000000027
+229712,Please modify the molecule Cc1cccc(C)c1N1CCN(S(=O)(=O)c2cc([N+](=O)[O-])ccc2Cl)CC1 to increase its LogP value.,Cc1cccc(C)c1N1CCN(S(=O)(=O)c2cc([N+](=O)[O-])ccc2Cl)CC1,3.3759400000000026
+44503,Please optimize the molecule COc1ccc2c(COC(=O)c3ccc4c(=O)n5c(nc4c3)CCC5)cc(=O)oc2c1 to have a lower LogP value.,COc1ccc2c(COC(=O)c3ccc4c(=O)n5c(nc4c3)CCC5)cc(=O)oc2c1,2.814700000000001
+96849,Modify the molecule C[C@@H]1CCN(C(=O)Nc2nnc(C(F)(F)F)s2)C[C@@H]1O to decrease its LogP value.,C[C@@H]1CCN(C(=O)Nc2nnc(C(F)(F)F)s2)C[C@@H]1O,1.7914999999999996
+88065,Modify the molecule CC(C)CC1(CNC(=O)N2CCC[C@@H](NS(C)(=O)=O)C2)CCCC1 to decrease its LogP value.,CC(C)CC1(CNC(=O)N2CCC[C@@H](NS(C)(=O)=O)C2)CCCC1,2.3160999999999996
+58222,Optimize the molecule CC1(C)Cc2cccc(OCC(=O)Nc3nnc(C4CC4)s3)c2O1 to have a lower LogP value.,CC1(C)Cc2cccc(OCC(=O)Nc3nnc(C4CC4)s3)c2O1,3.1465000000000014
+236285,Please modify the molecule Cc1cccc(C)c1NC(=O)CN1CCN(C(=O)c2ccccc2)CC1 to increase its LogP value.,Cc1cccc(C)c1NC(=O)CN1CCN(C(=O)c2ccccc2)CC1,2.6999400000000007
+109974,Please optimize the molecule Cn1ncc2c1CCC[C@H]2NC(=O)NCC(C)(C)NC(=O)OC(C)(C)C to have a lower LogP value.,Cn1ncc2c1CCC[C@H]2NC(=O)NCC(C)(C)NC(=O)OC(C)(C)C,2.3999999999999995
+200318,Please optimize the molecule CC(C)C(=O)N1CCC[C@@H]1C(=O)N1C[C@H]2C[NH+]3CCCC[C@@H]3[C@@H]2C1 to have a higher LogP value.,CC(C)C(=O)N1CCC[C@@H]1C(=O)N1C[C@H]2C[NH+]3CCCC[C@@H]3[C@@H]2C1,0.15900000000000336
+161945,Modify the molecule COC(=O)c1ccc(NC(=S)NC(=O)CC(C)(C)C)cc1 to have a higher LogP value.,COC(=O)c1ccc(NC(=S)NC(=O)CC(C)(C)C)cc1,2.7224000000000004
+152614,Please modify the molecule CN(Cc1cccc(NN)[nH+]1)Cc1cc(Br)cs1 to increase its LogP value.,CN(Cc1cccc(NN)[nH+]1)Cc1cc(Br)cs1,2.2423
+34285,Optimize the molecule CCOC(=O)N[C@H](OCC)c1ccccc1 to have a lower LogP value.,CCOC(=O)N[C@H](OCC)c1ccccc1,2.4678000000000004
+83673,Modify the molecule C[C@H](CCc1ccccc1F)C(=O)N1CCC(n2cncn2)CC1 to increase its LogP value.,C[C@H](CCc1ccccc1F)C(=O)N1CCC(n2cncn2)CC1,2.8496000000000015
+115652,Optimize the molecule Cc1ccc(F)cc1NC(=O)[C@@H](C(C)C)N1C(=O)c2ccccc2C1=O to have a lower LogP value.,Cc1ccc(F)cc1NC(=O)[C@@H](C(C)C)N1C(=O)c2ccccc2C1=O,3.3934200000000025
+28087,Please optimize the molecule CC(C)OC(=O)N1CCC2(CC1)C[C@H](c1ccccc1)C(=O)N(C)C2 to have a lower LogP value.,CC(C)OC(=O)N1CCC2(CC1)C[C@H](c1ccccc1)C(=O)N(C)C2,3.259500000000002
+51112,Modify the molecule CN(Cc1ccc(OC(F)F)cc1)C(=O)Nc1ccc(N(C)C)cc1C(F)(F)F to have a lower LogP value.,CN(Cc1ccc(OC(F)F)cc1)C(=O)Nc1ccc(N(C)C)cc1C(F)(F)F,5.036700000000004
+39255,Please optimize the molecule C[C@@H]1CCO[C@@H]1C(=O)Nc1ccc2c(c1)nc(C(C)(C)C)n2C to have a higher LogP value.,C[C@@H]1CCO[C@@H]1C(=O)Nc1ccc2c(c1)nc(C(C)(C)C)n2C,3.234300000000002
+130935,Please optimize the molecule CC(C)c1nn(C)c2sc(C(=O)N3CCO[C@@H](c4ccccc4)C3)cc12 to have a lower LogP value.,CC(C)c1nn(C)c2sc(C(=O)N3CCO[C@@H](c4ccccc4)C3)cc12,3.9719000000000033
+193721,Please optimize the molecule O=C1COc2cc(S(=O)(=O)N[C@@H]3C[C@H]3c3cccc(F)c3)c(Cl)cc2N1 to have a higher LogP value.,O=C1COc2cc(S(=O)(=O)N[C@@H]3C[C@H]3c3cccc(F)c3)c(Cl)cc2N1,2.6444
+134360,Please modify the molecule C[NH+]1CCC[C@H](C(=O)NC[C@@H](C2CC2)[NH+](C)C)C1 to decrease its LogP value.,C[NH+]1CCC[C@H](C(=O)NC[C@@H](C2CC2)[NH+](C)C)C1,-2.0495999999999945
+213298,Please modify the molecule CCNC(=O)N1CCN(C(=O)C(=O)NCCCc2ccccc2)CC1 to decrease its LogP value.,CCNC(=O)N1CCN(C(=O)C(=O)NCCCc2ccccc2)CC1,0.6091000000000018
+202690,Modify the molecule C[C@H]1C[C@H](C)C[NH+](C[C@H](O)COc2ccccc2C#N)C1 to decrease its LogP value.,C[C@H]1C[C@H](C)C[NH+](C[C@H](O)COc2ccccc2C#N)C1,0.8587800000000004
+241701,Please optimize the molecule CN(C)C(=O)c1cccnc1SCc1cccc(Br)c1 to have a higher LogP value.,CN(C)C(=O)c1cccnc1SCc1cccc(Br)c1,3.838200000000003
+94509,Please modify the molecule COc1cc(C)ccc1NCC(=O)NCCc1ccccc1C to increase its LogP value.,COc1cc(C)ccc1NCC(=O)NCCc1ccccc1C,3.082840000000002
+233572,Modify the molecule C[C@H](Sc1ncc(-c2ccc(F)cc2)[nH]1)C(=O)Nc1ccc(S(=O)(=O)N2CCCC2)cc1 to increase its LogP value.,C[C@H](Sc1ncc(-c2ccc(F)cc2)[nH]1)C(=O)Nc1ccc(S(=O)(=O)N2CCCC2)cc1,4.119600000000003
+181104,Modify the molecule O=C1C[C@H](C(=O)N2CCOC[C@@H]2C2CC2)CN1C1CCCCCC1 to have a higher LogP value.,O=C1C[C@H](C(=O)N2CCOC[C@@H]2C2CC2)CN1C1CCCCCC1,2.1951
+225871,Optimize the molecule Cc1ccc(O)cc1N/C=C1/C(=O)N(c2ccccc2Cl)C(=O)c2ccccc21 to have a lower LogP value.,Cc1ccc(O)cc1N/C=C1/C(=O)N(c2ccccc2Cl)C(=O)c2ccccc21,4.994020000000003
+33405,Please modify the molecule CCN1CCO[C@H](C[NH3+])[C@@H]1c1cccc(C2CC2)c1 to decrease its LogP value.,CCN1CCO[C@H](C[NH3+])[C@@H]1c1cccc(C2CC2)c1,1.5677000000000003
+17571,Optimize the molecule Cc1ccc(C)c(-n2ncc(C[NH3+])c2C(F)F)c1 to have a lower LogP value.,Cc1ccc(C)c(-n2ncc(C[NH3+])c2C(F)F)c1,2.16864
+109743,Optimize the molecule CCC(=O)N1CCc2cc(S(=O)(=O)N[C@H](C(=O)N[C@H]3CCCc4ccccc43)C(C)C)ccc21 to have a lower LogP value.,CCC(=O)N1CCc2cc(S(=O)(=O)N[C@H](C(=O)N[C@H]3CCCc4ccccc43)C(C)C)ccc21,3.482400000000002
+61022,Modify the molecule O=C1C[C@H](Cc2ccc(NC(=O)N[C@@H]3CCc4ccccc43)cc2)C(=O)N1 to increase its LogP value.,O=C1C[C@H](Cc2ccc(NC(=O)N[C@@H]3CCc4ccccc43)cc2)C(=O)N1,2.7008
+107053,Please optimize the molecule CC(C)c1cccc2c1N[C@@H](c1ccc(O)cc1)[C@@H]1CC=C[C@H]21 to have a lower LogP value.,CC(C)c1cccc2c1N[C@@H](c1ccc(O)cc1)[C@@H]1CC=C[C@H]21,5.342100000000005
+198999,Optimize the molecule Cc1cc(-c2c[nH+]c(N)cc2C)ccc1F to have a lower LogP value.,Cc1cc(-c2c[nH+]c(N)cc2C)ccc1F,2.505840000000001
+150422,Please optimize the molecule O=c1c2c3nc4ccccc4nc3n(/N=C/c3cccc(Cl)c3)c2ncn1-c1ccccc1 to have a higher LogP value.,O=c1c2c3nc4ccccc4nc3n(/N=C/c3cccc(Cl)c3)c2ncn1-c1ccccc1,4.819200000000004
+209382,Modify the molecule CC[C@H](O)C[C@@H](Cc1ccccc1OC)C(=O)[O-] to increase its LogP value.,CC[C@H](O)C[C@@H](Cc1ccccc1OC)C(=O)[O-],0.7647999999999997
+20289,Please modify the molecule CCOc1cccc(NC(=O)c2ccc(C(F)(F)F)nc2[O-])c1 to decrease its LogP value.,CCOc1cccc(NC(=O)c2ccc(C(F)(F)F)nc2[O-])c1,2.825
+156128,Modify the molecule CCn1nc(C)c(Br)c1COc1ccc(CCl)nc1 to have a lower LogP value.,CCn1nc(C)c(Br)c1COc1ccc(CCl)nc1,3.686720000000002
+114795,Optimize the molecule O=C(NCC1(c2ccc(Cl)cc2)CCOCC1)c1cccnc1N1CCCC1 to have a lower LogP value.,O=C(NCC1(c2ccc(Cl)cc2)CCOCC1)c1cccnc1N1CCCC1,3.8134000000000032
+98615,Modify the molecule O=C([O-])c1ccc2c(c1)S(=O)(=O)N(CC1CCCC1)C2=O to decrease its LogP value.,O=C([O-])c1ccc2c(c1)S(=O)(=O)N(CC1CCCC1)C2=O,0.3847999999999998
+71494,Modify the molecule Cc1ccccc1CNC(=O)C[NH+]1CCC[C@@H]1CN1CCOCC1 to increase its LogP value.,Cc1ccccc1CNC(=O)C[NH+]1CCC[C@@H]1CN1CCOCC1,-0.009279999999997957
+117379,Please optimize the molecule O=C(Nc1ccc(C(=O)N2CCCC2)cc1)N1C[C@@H]2CCCC[C@H]2C1 to have a lower LogP value.,O=C(Nc1ccc(C(=O)N2CCCC2)cc1)N1C[C@@H]2CCCC[C@H]2C1,3.576500000000003
+131483,Optimize the molecule CC[NH2+]Cc1cc(Br)ccc1OC[C@@H](C)C(N)=O to have a higher LogP value.,CC[NH2+]Cc1cc(Br)ccc1OC[C@@H](C)C(N)=O,1.0326
+242032,Please modify the molecule Cc1nc(C(=O)Nc2ccc(C(F)(F)F)cc2)c(C)o1 to decrease its LogP value.,Cc1nc(C(=O)Nc2ccc(C(F)(F)F)cc2)c(C)o1,3.562540000000002
+183434,Please modify the molecule O=c1cc(CNc2ccc3c(c2)CCC3)c2c(ccc3ccccc32)o1 to decrease its LogP value.,O=c1cc(CNc2ccc3c(c2)CCC3)c2c(ccc3ccccc32)o1,5.047000000000004
+213200,Optimize the molecule CN(C)C(=O)N1CC[C@H](O)C1 to have a higher LogP value.,CN(C)C(=O)N1CC[C@H](O)C1,-0.26539999999999986
+233398,Please optimize the molecule Cc1cc(SCC(=O)N[C@H](C)C(=O)N(C)C)nc2ccccc12 to have a higher LogP value.,Cc1cc(SCC(=O)N[C@H](C)C(=O)N(C)C)nc2ccccc12,2.2282199999999994
+166720,Modify the molecule CC1(C)C[C@H](NC(=O)C2CC[NH+](Cc3ccccc3F)CC2)c2ccccc2O1 to have a lower LogP value.,CC1(C)C[C@H](NC(=O)C2CC[NH+](Cc3ccccc3F)CC2)c2ccccc2O1,3.039200000000002
+75798,Please modify the molecule Cn1/c(=N/C(=O)C2CCCCC2)sc2cc3c(cc21)OCCO3 to decrease its LogP value.,Cn1/c(=N/C(=O)C2CCCCC2)sc2cc3c(cc21)OCCO3,3.018600000000001
+20441,Please modify the molecule C[C@H](CNC(=O)c1ccc(N)c([N+](=O)[O-])c1)Oc1ccccc1F to decrease its LogP value.,C[C@H](CNC(=O)c1ccc(N)c([N+](=O)[O-])c1)Oc1ccccc1F,2.5134000000000007
+100385,Please optimize the molecule CCC1(CC)[C@@H](OC)C[C@H]1[NH2+][C@@H](C)c1cccc(NC(C)=O)c1 to have a lower LogP value.,CCC1(CC)[C@@H](OC)C[C@H]1[NH2+][C@@H](C)c1cccc(NC(C)=O)c1,2.8631
+177864,Please modify the molecule Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@@H](C)Cl)cc1 to decrease its LogP value.,Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@@H](C)Cl)cc1,3.490820000000002
+171680,Modify the molecule Cc1cccc(C)c1Oc1ccccc1NC(=O)N[C@@H]1C=C[C@H](CO)C1 to increase its LogP value.,Cc1cccc(C)c1Oc1ccccc1NC(=O)N[C@@H]1C=C[C@H](CO)C1,4.154240000000002
+241458,Please optimize the molecule CC(C)COC(=O)[C@@]12CCC(=O)N1c1ccccc1C(=O)N2CC(C)C to have a higher LogP value.,CC(C)COC(=O)[C@@]12CCC(=O)N1c1ccccc1C(=O)N2CC(C)C,2.8207000000000013
+23250,Modify the molecule CC(=NNC(=O)c1ccccc1)c1cccc(N)c1 to have a lower LogP value.,CC(=NNC(=O)c1ccccc1)c1cccc(N)c1,2.4228000000000005
+177618,Modify the molecule CC[C@@](C)([C@H](Cc1cc(C)nn1C)[NH2+]C)[NH+]1CCCCC1 to decrease its LogP value.,CC[C@@](C)([C@H](Cc1cc(C)nn1C)[NH2+]C)[NH+]1CCCCC1,0.07032000000000305
+16987,Modify the molecule COC(=O)/C(C(C)=O)=C(\C=C\C=C\[NH+](C)C)N(C)C to have a lower LogP value.,COC(=O)/C(C(C)=O)=C(\C=C\C=C\[NH+](C)C)N(C)C,-0.22149999999999825
+28031,Please optimize the molecule COCC[NH+]1[C@@H](C)CN(Cc2cccn2C)C[C@H]1C to have a higher LogP value.,COCC[NH+]1[C@@H](C)CN(Cc2cccn2C)C[C@H]1C,0.14900000000000224
+169413,Please modify the molecule N#Cc1ccc(Cl)c(NC(=O)NC2(c3ccccc3F)CC2)c1 to increase its LogP value.,N#Cc1ccc(Cl)c(NC(=O)NC2(c3ccccc3F)CC2)c1,4.161580000000002
+130273,Modify the molecule CC(C)[C@@](C)(O)CNC(=O)N[C@@H](C)c1nc(C(C)(C)C)no1 to increase its LogP value.,CC(C)[C@@](C)(O)CNC(=O)N[C@@H](C)c1nc(C(C)(C)C)no1,2.1343000000000005
+238980,Please modify the molecule O=C(OCc1ccc([N+](=O)[O-])cc1)[C@H]1COc2ccccc2O1 to increase its LogP value.,O=C(OCc1ccc([N+](=O)[O-])cc1)[C@H]1COc2ccccc2O1,2.4780000000000006
+72403,Please optimize the molecule CCn1c2ccccc2c2cc(NC(=O)c3ccnc(-n4cncn4)c3)ccc21 to have a higher LogP value.,CCn1c2ccccc2c2cc(NC(=O)c3ccnc(-n4cncn4)c3)ccc21,4.042400000000002
+398,Please optimize the molecule N#CCCN(Cc1ccccc1)C(=S)NC(=O)c1cccc(Cl)c1 to have a lower LogP value.,N#CCCN(Cc1ccccc1)C(=S)NC(=O)c1cccc(Cl)c1,3.7705800000000025
+127232,Modify the molecule CCc1n[nH]c(NC(=O)c2[nH]nc3c2C[C@@H](C)CC3)n1 to decrease its LogP value.,CCc1n[nH]c(NC(=O)c2[nH]nc3c2C[C@@H](C)CC3)n1,1.4672999999999998
+158247,Modify the molecule CC[C@H](NC(=O)C[C@H]1CCCO1)c1nc(C(F)(F)F)cs1 to have a lower LogP value.,CC[C@H](NC(=O)C[C@H]1CCCO1)c1nc(C(F)(F)F)cs1,3.298300000000002
+100365,Optimize the molecule O=C(CN1CSCC1=O)Nc1cc(Cl)ccc1OC[C@H]1CCCO1 to have a lower LogP value.,O=C(CN1CSCC1=O)Nc1cc(Cl)ccc1OC[C@H]1CCCO1,2.3692
+231624,Modify the molecule CCc1nc([C@H](C)[NH2+][C@H](C)c2nccs2)cs1 to have a higher LogP value.,CCc1nc([C@H](C)[NH2+][C@H](C)c2nccs2)cs1,2.547600000000001
+45320,Modify the molecule CC[C@H](NC(=O)c1ccc(-n2ccnn2)cc1)C(=O)N1CCOCC1 to have a lower LogP value.,CC[C@H](NC(=O)c1ccc(-n2ccnn2)cc1)C(=O)N1CCOCC1,0.6345000000000001
+93058,Please optimize the molecule CCN(C1CC1)S(=O)(=O)c1ccc(F)c(C(=O)[O-])c1F to have a lower LogP value.,CCN(C1CC1)S(=O)(=O)c1ccc(F)c(C(=O)[O-])c1F,0.5013000000000002
+174131,Modify the molecule COC(=O)CC1CC[NH+]([C@@H]2CCC[C@@H](C)C2)CC1 to decrease its LogP value.,COC(=O)CC1CC[NH+]([C@@H]2CCC[C@@H](C)C2)CC1,1.4230999999999991
+202071,Modify the molecule O=C(CSc1nccn(-c2cccc(F)c2)c1=O)Nc1ccc(F)c(Cl)c1 to have a higher LogP value.,O=C(CSc1nccn(-c2cccc(F)c2)c1=O)Nc1ccc(F)c(Cl)c1,3.8949000000000025
+141392,Modify the molecule COC(=O)C(C)(C)NC(=O)c1ccc(C)cc1 to increase its LogP value.,COC(=O)C(C)(C)NC(=O)c1ccc(C)cc1,1.6764199999999996
+33702,Please optimize the molecule Cn1cccc1C(=O)COc1ccccc1I to have a higher LogP value.,Cn1cccc1C(=O)COc1ccccc1I,2.8914000000000017
+186105,Please optimize the molecule CC(C)c1ccc(S(=O)(=O)Nc2ccc3c(c2)CCC3)cc1 to have a higher LogP value.,CC(C)c1ccc(S(=O)(=O)Nc2ccc3c(c2)CCC3)cc1,4.0995000000000035
+109381,Modify the molecule CCOc1ccc(-c2noc(CCC(=O)NC3[C@@H](C)CCC[C@@H]3C)n2)cc1 to increase its LogP value.,CCOc1ccc(-c2noc(CCC(=O)NC3[C@@H](C)CCC[C@@H]3C)n2)cc1,4.0088000000000035
+109146,Modify the molecule CCCc1nnc(NC(=O)Cn2cnc3ccccc3c2=O)s1 to have a higher LogP value.,CCCc1nnc(NC(=O)Cn2cnc3ccccc3c2=O)s1,1.8392000000000002
+163524,Please modify the molecule Cc1cc(C)n(-c2ccc(C(=O)OCCN3C(=O)c4ccccc4C3=O)cc2)n1 to increase its LogP value.,Cc1cc(C)n(-c2ccc(C(=O)OCCN3C(=O)c4ccccc4C3=O)cc2)n1,2.942140000000001
+90885,Modify the molecule CN(C)c1c(Cl)cccc1NC(=O)N1CCCN(c2nccs2)CC1 to decrease its LogP value.,CN(C)c1c(Cl)cccc1NC(=O)N1CCCN(c2nccs2)CC1,3.6067000000000027
+204370,Modify the molecule CCOC(=O)C1CC[NH+]([C@@H](c2ccccc2)c2sc3nc(CC)nn3c2O)CC1 to increase its LogP value.,CCOC(=O)C1CC[NH+]([C@@H](c2ccccc2)c2sc3nc(CC)nn3c2O)CC1,2.0061999999999998
+94100,Modify the molecule CN(C)C(=O)c1cccc(C(=O)N[C@@H](CO)CC(C)(C)C)c1 to have a higher LogP value.,CN(C)C(=O)c1cccc(C(=O)N[C@@H](CO)CC(C)(C)C)c1,1.9152999999999993
+102489,Please modify the molecule Cc1cccn2c(=O)c(C(=O)NC[C@H](C)CCO)cnc12 to decrease its LogP value.,Cc1cccn2c(=O)c(C(=O)NC[C@H](C)CCO)cnc12,0.7512199999999993
+197738,Modify the molecule O=C(Cc1ccc(Cl)cc1)NC[C@H](O)c1cccc2ccccc12 to have a lower LogP value.,O=C(Cc1ccc(Cl)cc1)NC[C@H](O)c1cccc2ccccc12,3.885500000000002
+246824,Please optimize the molecule COC(=O)CCC[NH+]1CCC(CS(N)(=O)=O)CC1 to have a lower LogP value.,COC(=O)CCC[NH+]1CCC(CS(N)(=O)=O)CC1,-1.4769999999999968
+43939,Modify the molecule C[C@H](OCc1cc(F)ccc1N)c1ccccc1 to increase its LogP value.,C[C@H](OCc1cc(F)ccc1N)c1ccccc1,3.6857000000000015
+216587,Please optimize the molecule CCOC(=O)[C@H](Cc1ccccc1)NC(=O)c1cncc(C)c1 to have a lower LogP value.,CCOC(=O)[C@H](Cc1ccccc1)NC(=O)c1cncc(C)c1,2.29422
+77230,Please modify the molecule C[NH+]1CCCCC[C@@H]1C(=O)NCc1ccc(O)cc1 to increase its LogP value.,C[NH+]1CCCCC[C@@H]1C(=O)NCc1ccc(O)cc1,0.4656999999999999
+246573,Please modify the molecule Cc1nc(C2CC[NH+](CC(C)(C)C)CC2)n[nH]1 to increase its LogP value.,Cc1nc(C2CC[NH+](CC(C)(C)C)CC2)n[nH]1,0.9215199999999999
+37746,Please modify the molecule CC[C@H](N[C@H](C)c1nc2ccccc2n1C(F)F)c1ccncc1 to decrease its LogP value.,CC[C@H](N[C@H](C)c1nc2ccccc2n1C(F)F)c1ccncc1,4.628300000000004
+176872,Please optimize the molecule COc1ccccc1N1C(=O)/C(=C\C=C\c2ccccc2)C(=O)N(c2ccccc2)C1=S to have a higher LogP value.,COc1ccccc1N1C(=O)/C(=C\C=C\c2ccccc2)C(=O)N(c2ccccc2)C1=S,4.999700000000003
+242852,Modify the molecule O=C([O-])C1CN(c2cnccn2)C1 to increase its LogP value.,O=C([O-])C1CN(c2cnccn2)C1,-1.3373000000000004
+144474,Modify the molecule O=C(NCc1ccc(F)cc1)Nc1cccc(C(F)(F)F)c1 to decrease its LogP value.,O=C(NCc1ccc(F)cc1)Nc1cccc(C(F)(F)F)c1,4.166200000000002
+197095,Please optimize the molecule CCCNC(=O)NNC(=O)COc1cccc(C)c1 to have a higher LogP value.,CCCNC(=O)NNC(=O)COc1cccc(C)c1,1.11422
+38725,Modify the molecule NC(=O)c1ccc(N2CCCCC2)c(NC(=O)Cc2ccccc2)c1 to have a higher LogP value.,NC(=O)c1ccc(N2CCCCC2)c(NC(=O)Cc2ccccc2)c1,2.9570000000000016
+19004,Please optimize the molecule CC(C)CN(C)C(=O)N[C@@H](C)c1ccc(-n2cncn2)cc1 to have a higher LogP value.,CC(C)CN(C)C(=O)N[C@@H](C)c1ccc(-n2cncn2)cc1,2.625700000000001
+221445,Modify the molecule CCOc1ccc2c(C(=O)NCC3CC3)cc(=O)oc2c1 to decrease its LogP value.,CCOc1ccc2c(C(=O)NCC3CC3)cc(=O)oc2c1,2.3315
+61805,Modify the molecule Cc1ccc(NC(=O)N2CCc3[nH]c4ccccc4c3C2)cc1C(N)=O to have a lower LogP value.,Cc1ccc(NC(=O)N2CCc3[nH]c4ccccc4c3C2)cc1C(N)=O,3.16542
+241852,Please modify the molecule COc1ccccc1NC(=[NH2+])SCc1cccc(C(N)=O)c1 to increase its LogP value.,COc1ccccc1NC(=[NH2+])SCc1cccc(C(N)=O)c1,1.2545000000000002
+197353,Modify the molecule N#Cc1cnn(CCN2CCO[C@H](CNc3cccn[nH+]3)C2)c1 to have a lower LogP value.,N#Cc1cnn(CCN2CCO[C@H](CNc3cccn[nH+]3)C2)c1,-0.2232199999999993
+293,Modify the molecule Cc1cccc(C)c1NC(=O)C[NH+]1CCC(OCc2ccc(F)cc2)CC1 to increase its LogP value.,Cc1cccc(C)c1NC(=O)C[NH+]1CCC(OCc2ccc(F)cc2)CC1,2.6451400000000005
+226556,Please optimize the molecule COC(=O)c1ccc(CN2CCN(CCn3cc[nH+]c3C)CC2)cc1 to have a higher LogP value.,COC(=O)c1ccc(CN2CCN(CCn3cc[nH+]c3C)CC2)cc1,1.2150199999999998
+60892,Modify the molecule CC(C)c1nc(CNC(=O)[C@H]2Cc3cc(F)ccc3O2)cs1 to increase its LogP value.,CC(C)c1nc(CNC(=O)[C@H]2Cc3cc(F)ccc3O2)cs1,3.025500000000001
+148398,Modify the molecule C[C@H](NC(=O)NC[C@@H]1CC[NH+](C2CC2)C1)C(=O)N1CCCCC1 to have a lower LogP value.,C[C@H](NC(=O)NC[C@@H]1CC[NH+](C2CC2)C1)C(=O)N1CCCCC1,-0.2461999999999971
+148875,Please modify the molecule O=C(c1ccn(-c2ccc(Cl)cc2Cl)n1)N1CCCCC1 to increase its LogP value.,O=C(c1ccn(-c2ccc(Cl)cc2Cl)n1)N1CCCCC1,3.805200000000003
+27089,Optimize the molecule COc1ccc(C[NH+]2CCN(CCO)CC2)cc1 to have a lower LogP value.,COc1ccc(C[NH+]2CCN(CCO)CC2)cc1,-0.6119999999999983
+171203,Please modify the molecule C[C@H](NC(=O)C1CCCCC1)C(=O)N1CCO[C@@H](c2ccccc2F)C1 to decrease its LogP value.,C[C@H](NC(=O)C1CCCCC1)C(=O)N1CCO[C@@H](c2ccccc2F)C1,2.810600000000001
+69351,Modify the molecule Cc1nc(S[C@H](C)C(=O)NC(N)=O)c(C#N)c(C)c1C to increase its LogP value.,Cc1nc(S[C@H](C)C(=O)NC(N)=O)c(C#N)c(C)c1C,1.5540400000000003
+134254,Modify the molecule CCOC(=O)[C@H](CC(C)C)Nc1ncnc2onc(C)c12 to increase its LogP value.,CCOC(=O)[C@H](CC(C)C)Nc1ncnc2onc(C)c12,2.31592
+122778,Optimize the molecule CC[C@H](NC(=O)C(=O)c1c(C)nn(-c2ccccc2)c1C)c1ccc(Cl)cc1 to have a lower LogP value.,CC[C@H](NC(=O)C(=O)c1c(C)nn(-c2ccccc2)c1C)c1ccc(Cl)cc1,4.592740000000004
+100995,Modify the molecule CC[NH2+][C@H](CSCC)[C@@H]1CCC[C@H](S(C)(=O)=O)C1 to have a higher LogP value.,CC[NH2+][C@H](CSCC)[C@@H]1CCC[C@H](S(C)(=O)=O)C1,1.2948000000000004
+223286,Modify the molecule C[NH+](C)[C@@H](CNC(=O)N[C@@H](CO)c1ccccc1)c1cccc(F)c1 to have a higher LogP value.,C[NH+](C)[C@@H](CNC(=O)N[C@@H](CO)c1ccccc1)c1cccc(F)c1,1.044100000000001
+244385,Modify the molecule Cc1ccc(NC(=O)C(=O)N2CSC[C@H]2C(=O)[O-])cc1 to have a lower LogP value.,Cc1ccc(NC(=O)C(=O)N2CSC[C@H]2C(=O)[O-])cc1,-0.4150800000000001
+195437,Modify the molecule C[C@H]1CCN(CCCN2C(=O)NC(C)(C)C2=O)c2ccccc21 to increase its LogP value.,C[C@H]1CCN(CCCN2C(=O)NC(C)(C)C2=O)c2ccccc21,2.720700000000001
+152366,Please modify the molecule O=C([O-])Cn1nc(-c2ccco2)ccc1=O to increase its LogP value.,O=C([O-])Cn1nc(-c2ccco2)ccc1=O,-0.7468000000000004
+20734,Please optimize the molecule Cc1cc(O)c(C(=O)c2ccccc2)cc1Cl to have a lower LogP value.,Cc1cc(O)c(C(=O)c2ccccc2)cc1Cl,3.585020000000001
+75953,Modify the molecule O=C(CO)Nc1cccc([N-]S(=O)(=O)c2ccccc2Cl)c1 to have a lower LogP value.,O=C(CO)Nc1cccc([N-]S(=O)(=O)c2ccccc2Cl)c1,2.664900000000001
+4194,Modify the molecule Cc1ccc(CC(=O)NCC2(c3ccccc3Cl)CC2)cc1O to have a lower LogP value.,Cc1ccc(CC(=O)NCC2(c3ccccc3Cl)CC2)cc1O,3.7445200000000027
+185511,Please modify the molecule C[C@H]1CCC[C@H](NC(=O)CSCCn2c(=O)oc3cccnc32)[C@@H]1C to decrease its LogP value.,C[C@H]1CCC[C@H](NC(=O)CSCCn2c(=O)oc3cccnc32)[C@@H]1C,2.6636000000000006
+78829,Modify the molecule Cc1cc(CN(C)C(=O)c2cnn(-c3ccc(Cl)cc3)c2)no1 to increase its LogP value.,Cc1cc(CN(C)C(=O)c2cnn(-c3ccc(Cl)cc3)c2)no1,3.0943200000000015
+206629,Modify the molecule COc1ccc(C(=O)N2CCC[C@@H](C[NH3+])C2)cc1O to have a higher LogP value.,COc1ccc(C(=O)N2CCC[C@@H](C[NH3+])C2)cc1O,0.4949000000000004
+101495,Modify the molecule CC[C@H]1CN(C[C@H](O)c2ccc(F)cc2F)CC[NH+]1C[C@@H](C)O to have a higher LogP value.,CC[C@H]1CN(C[C@H](O)c2ccc(F)cc2F)CC[NH+]1C[C@@H](C)O,0.3580999999999999
+58087,Please optimize the molecule O=[S@](Cc1nnc(Cc2ccccc2)o1)c1ccc2ccccc2c1 to have a higher LogP value.,O=[S@](Cc1nnc(Cc2ccccc2)o1)c1ccc2ccccc2c1,4.121400000000003
+153061,Optimize the molecule Cc1ccccc1C[C@H]([NH3+])[C@H]1CSCCO1 to have a higher LogP value.,Cc1ccccc1C[C@H]([NH3+])[C@H]1CSCCO1,1.2800200000000002
+6452,Optimize the molecule Cc1nc(CC(=O)N[C@@H]2CCC[C@@H]2c2ccccc2C(F)(F)F)cs1 to have a higher LogP value.,Cc1nc(CC(=O)N[C@@H]2CCC[C@@H]2c2ccccc2C(F)(F)F)cs1,4.465320000000004
+14254,Optimize the molecule CCOc1cc2c(cc1NC(=O)CCc1c(C)[nH]c(=O)[nH]c1=O)O[C@@H](C)C2 to have a higher LogP value.,CCOc1cc2c(cc1NC(=O)CCc1c(C)[nH]c(=O)[nH]c1=O)O[C@@H](C)C2,1.66502
+1188,Please modify the molecule Fc1cccc(Oc2nc(-c3ccncc3)nc3c2CCC3)c1F to decrease its LogP value.,Fc1cccc(Oc2nc(-c3ccncc3)nc3c2CCC3)c1F,4.097800000000002
+150617,Please modify the molecule Cn1c(=O)oc2cc(NC(=O)NCc3cccc(C#N)c3)ccc21 to increase its LogP value.,Cn1c(=O)oc2cc(NC(=O)NCc3cccc(C#N)c3)ccc21,2.3248800000000003
+98356,Optimize the molecule Cc1cc(C)c2c(NC[C@H]3CCCN(C(=O)C4CC4)C3)ncnc2n1 to have a higher LogP value.,Cc1cc(C)c2c(NC[C@H]3CCCN(C(=O)C4CC4)C3)ncnc2n1,2.702140000000001
+194093,Optimize the molecule COc1ccc(-n2nc3cc(C)c(NC(=S)NC(=O)c4ccc5c(c4)OCO5)cc3n2)cc1Cl to have a lower LogP value.,COc1ccc(-n2nc3cc(C)c(NC(=S)NC(=O)c4ccc5c(c4)OCO5)cc3n2)cc1Cl,4.246420000000002
+238253,Modify the molecule C[NH+](CC(=O)Nc1cccnc1)Cc1ccc(F)c(F)c1 to decrease its LogP value.,C[NH+](CC(=O)Nc1cccnc1)Cc1ccc(F)c(F)c1,1.0132
+45776,Modify the molecule N#Cc1ccc(CNS(=O)(=O)c2ccc(C(=O)NCC(F)(F)F)cc2)cc1 to have a lower LogP value.,N#Cc1ccc(CNS(=O)(=O)c2ccc(C(=O)NCC(F)(F)F)cc2)cc1,2.3288800000000007
+144128,Please modify the molecule CNc1ccc2nc(CC[NH+](C)C)[nH]c2n1 to increase its LogP value.,CNc1ccc2nc(CC[NH+](C)C)[nH]c2n1,-0.3133999999999994
+60292,Modify the molecule Cc1nc(-c2nc[nH]n2)sc1C(=O)OCCc1c(C)n[nH]c1C to have a higher LogP value.,Cc1nc(-c2nc[nH]n2)sc1C(=O)OCCc1c(C)n[nH]c1C,1.9760599999999997
+173451,Please optimize the molecule CCn1ccc(=O)nc1SCC(=O)NC(C)(C)CC to have a higher LogP value.,CCn1ccc(=O)nc1SCC(=O)NC(C)(C)CC,1.6600999999999995
+69629,Modify the molecule COC(=O)c1c(C)[nH]c(C(=O)NCc2nc(-c3ccccc3)no2)c1C to decrease its LogP value.,COC(=O)c1c(C)[nH]c(C(=O)NCc2nc(-c3ccccc3)no2)c1C,2.3981400000000006
+202830,Please modify the molecule COc1ccc2c(c1)=[NH+][C@@H](C(=O)N1CCC([C@@H](C)C(=O)NCCC3=CCCCC3)CC1)C=2 to decrease its LogP value.,COc1ccc2c(c1)=[NH+][C@@H](C(=O)N1CCC([C@@H](C)C(=O)NCCC3=CCCCC3)CC1)C=2,0.43950000000000267
+206191,Modify the molecule COc1cccc(C[C@H](N[C@H](C)c2cnc3cc(C)nn3c2C)C2CC2)c1 to have a lower LogP value.,COc1cccc(C[C@H](N[C@H](C)c2cnc3cc(C)nn3c2C)C2CC2)c1,4.026640000000003
+94351,Please modify the molecule CC[C@](C)([C@@H](NC)c1c(C)cc[nH+]c1N)[NH+]1CCCC1 to decrease its LogP value.,CC[C@](C)([C@@H](NC)c1c(C)cc[nH+]c1N)[NH+]1CCCC1,0.4992200000000016
+73752,Please modify the molecule COCCOC(=O)/C(C#N)=C\c1ccc(Cl)cc1Cl to decrease its LogP value.,COCCOC(=O)/C(C#N)=C\c1ccc(Cl)cc1Cl,3.0899800000000015
+127346,Optimize the molecule c1ccc([C@@H]2C[C@H](c3ccco3)n3cnnc3N2)cc1 to have a lower LogP value.,c1ccc([C@@H]2C[C@H](c3ccco3)n3cnnc3N2)cc1,3.0174000000000003
+232654,Please optimize the molecule C[C@@H]([C@@H](C)O)[NH+](C)C[C@@H](C)C(=O)[O-] to have a lower LogP value.,C[C@@H]([C@@H](C)O)[NH+](C)C[C@@H](C)C(=O)[O-],-2.343599999999997
+195408,Please optimize the molecule O=[N+]([O-])c1cccc(N[C@@H]2CCCc3cccnc32)c1 to have a lower LogP value.,O=[N+]([O-])c1cccc(N[C@@H]2CCCc3cccnc32)c1,3.479300000000001
+217389,Please modify the molecule COCCN1C(=O)c2oc3cc(C)c(Cl)cc3c(=O)c2[C@@H]1c1ccc([N+](=O)[O-])cc1 to decrease its LogP value.,COCCN1C(=O)c2oc3cc(C)c(Cl)cc3c(=O)c2[C@@H]1c1ccc([N+](=O)[O-])cc1,3.8546200000000024
+237284,Optimize the molecule O=C(NC[C@@H](c1cccnc1)[NH+]1CCN(c2ccccc2)CC1)C(=O)Nc1cccc(F)c1 to have a higher LogP value.,O=C(NC[C@@H](c1cccnc1)[NH+]1CCN(c2ccccc2)CC1)C(=O)Nc1cccc(F)c1,1.4218000000000006
+14081,Modify the molecule CC(C)[C@@H]1CSC[C@@H](C(=O)[O-])[NH2+]1 to have a higher LogP value.,CC(C)[C@@H]1CSC[C@@H](C(=O)[O-])[NH2+]1,-1.5602999999999974
+73673,Modify the molecule COC(=O)c1c(OC[C@H]2CCCCO2)cc(=O)n2c1CC[NH+](Cc1c(F)cccc1F)CC2 to decrease its LogP value.,COC(=O)c1c(OC[C@H]2CCCCO2)cc(=O)n2c1CC[NH+](Cc1c(F)cccc1F)CC2,1.5022000000000004
+11596,Optimize the molecule CN(Cc1ccccc1)C(=O)CCNC(=O)N1CCC[C@@H]2CCC[C@@H]21 to have a higher LogP value.,CN(Cc1ccccc1)C(=O)CCNC(=O)N1CCC[C@@H]2CCC[C@@H]21,3.0092000000000017
+164862,Modify the molecule Cc1cccc(CC(=O)N2CCN(c3nnc(SCC(N)=O)s3)CC2)c1 to increase its LogP value.,Cc1cccc(CC(=O)N2CCN(c3nnc(SCC(N)=O)s3)CC2)c1,1.3152199999999996
+8406,Modify the molecule Cc1ccc(C)n1NC(=O)c1ccc(N)c(F)c1 to have a higher LogP value.,Cc1ccc(C)n1NC(=O)c1ccc(N)c(F)c1,2.21014
+244284,Please modify the molecule O=C(c1ccncc1)N(Cc1ccco1)Cc1cccs1 to decrease its LogP value.,O=C(c1ccncc1)N(Cc1ccco1)Cc1cccs1,3.578700000000002
+83043,Modify the molecule C[C@@H](O)C[C@@H](C)CNC(=O)c1cc([N+](=O)[O-])ccc1N1CCCCC1 to increase its LogP value.,C[C@@H](O)C[C@@H](C)CNC(=O)c1cc([N+](=O)[O-])ccc1N1CCCCC1,2.7219000000000007
+178226,Optimize the molecule COCCN1C(=O)NC(=N)[C@@]1(C)C1CC1 to have a higher LogP value.,COCCN1C(=O)NC(=N)[C@@]1(C)C1CC1,0.80397
+120071,Modify the molecule Cc1ccc(NC(=O)CN2CCN(Cc3cccc(Cl)c3)S2(=O)=O)cc1 to increase its LogP value.,Cc1ccc(NC(=O)CN2CCN(Cc3cccc(Cl)c3)S2(=O)=O)cc1,2.6495200000000008
+205534,Please modify the molecule Cc1ccccc1C(=O)N1CCN(c2cccc(Cl)c2C)C(=O)[C@@H]1C to decrease its LogP value.,Cc1ccccc1C(=O)N1CCN(c2cccc(Cl)c2C)C(=O)[C@@H]1C,3.8343400000000027
+6416,Optimize the molecule Cc1nnc(Nc2ccccc2)o1 to have a lower LogP value.,Cc1nnc(Nc2ccccc2)o1,2.12162
+127018,Please optimize the molecule O=C(CN(C1CCCCC1)S(=O)(=O)c1ccccc1)N1CCN(c2cccc(Cl)c2)CC1 to have a lower LogP value.,O=C(CN(C1CCCCC1)S(=O)(=O)c1ccccc1)N1CCN(c2cccc(Cl)c2)CC1,4.0122000000000035
+51459,Modify the molecule COc1ccccc1[C@@H]1C[NH+](CC(=O)N[C@@H](c2ccco2)C(F)(F)F)Cc2ccccc2O1 to decrease its LogP value.,COc1ccccc1[C@@H]1C[NH+](CC(=O)N[C@@H](c2ccco2)C(F)(F)F)Cc2ccccc2O1,3.226600000000002
+157506,Modify the molecule C[C@@]1(c2ccc(F)cc2)NC(=O)N(CN2CCN(S(=O)(=O)c3ccc4ccccc4c3)CC2)C1=O to increase its LogP value.,C[C@@]1(c2ccc(F)cc2)NC(=O)N(CN2CCN(S(=O)(=O)c3ccc4ccccc4c3)CC2)C1=O,2.709900000000001
+183099,Please modify the molecule CCN(Cc1ccccn1)CN1C(=O)N[C@@H](Cc2ccccc2)C1=O to decrease its LogP value.,CCN(Cc1ccccn1)CN1C(=O)N[C@@H](Cc2ccccc2)C1=O,2.0241
+199133,Optimize the molecule O=C(N/N=C/c1c(F)cccc1Cl)c1cc(-c2ccc(Br)cc2)n[nH]1 to have a lower LogP value.,O=C(N/N=C/c1c(F)cccc1Cl)c1cc(-c2ccc(Br)cc2)n[nH]1,4.395600000000002
+24533,Please modify the molecule Cn1c(SCc2cccc(Cl)c2)nnc1[C@@H]1COc2ccccc2O1 to increase its LogP value.,Cn1c(SCc2cccc(Cl)c2)nnc1[C@@H]1COc2ccccc2O1,4.273300000000003
+200460,Optimize the molecule C[NH+](C)[C@@H]1CC[C@@H](NC(=O)c2ccc(S(=O)(=O)[N-]c3ccncc3)cc2)C1 to have a higher LogP value.,C[NH+](C)[C@@H]1CC[C@@H](NC(=O)c2ccc(S(=O)(=O)[N-]c3ccncc3)cc2)C1,1.2711000000000006
+86620,Please optimize the molecule Cc1cccc(C(=O)NCCNC(=O)c2ccc(C(N)=O)cc2)c1 to have a lower LogP value.,Cc1cccc(C(=O)NCCNC(=O)c2ccc(C(N)=O)cc2)c1,1.25372
+116972,Please modify the molecule Cn1c([C@@H]2CCCN2C(=O)c2ccc3ncsc3c2)nc2ccccc21 to increase its LogP value.,Cn1c([C@@H]2CCCN2C(=O)c2ccc3ncsc3c2)nc2ccccc21,4.160300000000003
+115203,Please modify the molecule CCO[C@H]1C[NH+](C)C[C@@H]1NC(=O)c1ccc(C)c(N2CCNC2=O)c1 to decrease its LogP value.,CCO[C@H]1C[NH+](C)C[C@@H]1NC(=O)c1ccc(C)c(N2CCNC2=O)c1,-0.44357999999999587
+230934,Modify the molecule COc1ccccc1NC(=O)Nc1nnc(N2C[C@@H](C)C[C@H](C)C2)s1 to decrease its LogP value.,COc1ccccc1NC(=O)Nc1nnc(N2C[C@@H](C)C[C@H](C)C2)s1,3.6730000000000027
+172291,Optimize the molecule COc1ccc(OC)c([C@H]2CCCN2CN2C(=O)C(=O)c3ccccc32)c1 to have a higher LogP value.,COc1ccc(OC)c([C@H]2CCCN2CN2C(=O)C(=O)c3ccccc32)c1,3.027700000000002
+76218,Optimize the molecule CC(C)CCNC(=O)c1cc2c(=O)n3ccccc3nc2n1C to have a lower LogP value.,CC(C)CCNC(=O)c1cc2c(=O)n3ccccc3nc2n1C,1.9621
+110928,Optimize the molecule CN(Cc1ccccc1C(F)(F)F)C(=O)c1ccc(C(F)(F)F)cc1 to have a higher LogP value.,CN(Cc1ccccc1C(F)(F)F)C(=O)c1ccc(C(F)(F)F)cc1,4.996400000000003
+13394,Please modify the molecule COc1cc([C@H](C)[NH2+]C2C[C@@H](C)O[C@H](C)C2)ccc1SC(F)F to increase its LogP value.,COc1cc([C@H](C)[NH2+]C2C[C@@H](C)O[C@H](C)C2)ccc1SC(F)F,3.5903000000000027
+85431,Please modify the molecule CS[C@H]1CC[C@@H](NC(=O)c2cnn(-c3ccc(C)cc3)c2C(C)C)C1 to increase its LogP value.,CS[C@H]1CC[C@@H](NC(=O)c2cnn(-c3ccc(C)cc3)c2C(C)C)C1,4.318020000000003
+164883,Modify the molecule C[C@@H]1C[C@@H](C)CN(C(=O)Cc2csc(N3CCCC3=O)n2)C1 to have a higher LogP value.,C[C@@H]1C[C@@H](C)CN(C(=O)Cc2csc(N3CCCC3=O)n2)C1,2.3169000000000004
+176826,Please optimize the molecule CCCC[C@H](C(=O)[O-])[C@H](C)O to have a higher LogP value.,CCCC[C@H](C(=O)[O-])[C@H](C)O,-0.07650000000000018
+37578,Optimize the molecule C=CCNC(=O)C(=O)Nc1c2c(nn1-c1ccc(F)cc1)CS(=O)(=O)C2 to have a higher LogP value.,C=CCNC(=O)C(=O)Nc1c2c(nn1-c1ccc(F)cc1)CS(=O)(=O)C2,0.6804999999999997
+172957,Modify the molecule CS(=O)(=O)[C@@H]1CCC[C@@H](OCC[NH3+])C1 to have a higher LogP value.,CS(=O)(=O)[C@@H]1CCC[C@@H](OCC[NH3+])C1,-0.39929999999999843
+229455,Please modify the molecule Cc1noc(CNc2ccn(-c3ccc(Cl)cc3Cl)n2)n1 to increase its LogP value.,Cc1noc(CNc2ccn(-c3ccc(Cl)cc3Cl)n2)n1,3.4826200000000016
+121080,Modify the molecule COC(=O)c1ccc(NC(=O)Cn2cccc(-c3nc(-c4ccc(Cl)cc4)no3)c2=O)cc1 to increase its LogP value.,COC(=O)c1ccc(NC(=O)Cn2cccc(-c3nc(-c4ccc(Cl)cc4)no3)c2=O)cc1,3.644000000000002
+127496,Please modify the molecule O=C([O-])[C@H]1CCCN1C(=O)Cc1csc(-c2cccs2)n1 to increase its LogP value.,O=C([O-])[C@H]1CCCN1C(=O)Cc1csc(-c2cccs2)n1,1.1549999999999998
+33611,Optimize the molecule Cc1c(C)c2ccc(OCC(=O)NCCC[NH+](C)C)c(C)c2oc1=O to have a higher LogP value.,Cc1c(C)c2ccc(OCC(=O)NCCC[NH+](C)C)c(C)c2oc1=O,0.7478600000000013
+147980,Optimize the molecule C[NH2+][C@H]1CCC[C@H]([NH+](C)CCCOC)C1 to have a lower LogP value.,C[NH2+][C@H]1CCC[C@H]([NH+](C)CCCOC)C1,-0.957999999999996
+140056,Optimize the molecule CC[C@@](C)(C[NH3+])[C@H](O)c1ccccn1 to have a higher LogP value.,CC[C@@](C)(C[NH3+])[C@H](O)c1ccccn1,0.7731999999999997
+100676,Optimize the molecule N#CCN(C[C@H]1CCOC1)C1CCCC1 to have a higher LogP value.,N#CCN(C[C@H]1CCOC1)C1CCCC1,1.79108
+90960,Modify the molecule C[C@@H]1CN([C@@H]2CCCc3ccccc32)CCO1 to have a lower LogP value.,C[C@@H]1CN([C@@H]2CCCc3ccccc32)CCO1,2.784700000000001
+82432,Please modify the molecule CCN(Cc1cccc(Cl)c1)C(=O)NCCc1cc(F)cc2c1OCOC2 to decrease its LogP value.,CCN(Cc1cccc(Cl)c1)C(=O)NCCc1cc(F)cc2c1OCOC2,4.119800000000003
+141295,Modify the molecule CCc1nsc(NCc2ccccc2CN2CCOCC2)n1 to have a lower LogP value.,CCc1nsc(NCc2ccccc2CN2CCOCC2)n1,2.5448000000000004
+134618,Please modify the molecule Cc1nnc2sc(-c3ccc(CNC(=O)COc4ccc(Br)cc4)cc3)nn12 to increase its LogP value.,Cc1nnc2sc(-c3ccc(CNC(=O)COc4ccc(Br)cc4)cc3)nn12,3.618920000000002
+70967,Optimize the molecule Cc1nc(C)c(C(=O)NCc2cccc(NC(=O)CC(C)C)c2)o1 to have a higher LogP value.,Cc1nc(C)c(C(=O)NCc2cccc(NC(=O)CC(C)C)c2)o1,3.2060400000000016
+83274,Please modify the molecule Cc1ncccc1N1C(=O)[C@H](C2CC2)NC(=O)[C@H]1C to decrease its LogP value.,Cc1ncccc1N1C(=O)[C@H](C2CC2)NC(=O)[C@H]1C,1.01992
+204780,Modify the molecule COc1cc(C(=O)N/N=C2/C=C(C)CC2)ccc1OCCC(C)C to have a lower LogP value.,COc1cc(C(=O)N/N=C2/C=C(C)CC2)ccc1OCCC(C)C,3.9460000000000033
+180003,Optimize the molecule CCCCn1c([S@](=O)[C@@H](C)C(=O)Nc2cccc(C)c2C)n[nH]c1=O to have a higher LogP value.,CCCCn1c([S@](=O)[C@@H](C)C(=O)Nc2cccc(C)c2C)n[nH]c1=O,2.12314
+4014,Modify the molecule CCC[C@@](C)(CO)NC(=O)Nc1ccc(N2CCc3sccc3C2)cc1 to decrease its LogP value.,CCC[C@@](C)(CO)NC(=O)Nc1ccc(N2CCc3sccc3C2)cc1,3.9834000000000023
+125198,Modify the molecule CCn1ccnc(N2CCN(C(=O)C(=O)N3CCCC3)CC2)c1=O to have a lower LogP value.,CCn1ccnc(N2CCN(C(=O)C(=O)N3CCCC3)CC2)c1=O,-0.4657999999999982
+165884,Please modify the molecule Cc1ccc([C@H](C)N(C)C(=O)c2sc(C)nc2C)cc1 to decrease its LogP value.,Cc1ccc([C@H](C)N(C)C(=O)c2sc(C)nc2C)cc1,3.9015600000000035
+34906,Modify the molecule Cn1c(=O)[nH]c(=O)c2c1nc(SCC(=O)Nc1ccccc1)n2Cc1cccc(Cl)c1 to have a lower LogP value.,Cn1c(=O)[nH]c(=O)c2c1nc(SCC(=O)Nc1ccccc1)n2Cc1cccc(Cl)c1,2.8558000000000003
+205766,Please optimize the molecule O=C(Cc1ccc(NC(=O)Nc2ccc(C(F)(F)F)cc2)cc1)NCC(F)(F)F to have a higher LogP value.,O=C(Cc1ccc(NC(=O)Nc2ccc(C(F)(F)F)cc2)cc1)NCC(F)(F)F,4.570400000000002
+243910,Please optimize the molecule C#CC[NH+](CC(=O)[O-])[C@H]1CCO[C@@H](C(C)C)C1 to have a higher LogP value.,C#CC[NH+](CC(=O)[O-])[C@H]1CCO[C@@H](C(C)C)C1,-1.5419999999999963
+39221,Please modify the molecule COc1ccc(-c2nn(-c3ccccc3)cc2CCl)cc1 to increase its LogP value.,COc1ccc(-c2nn(-c3ccccc3)cc2CCl)cc1,4.286700000000003
+101313,Modify the molecule CCCCN(C[C@@H]1C=c2ccc(C)cc2=[NH+]C1=O)C(=O)c1ccc(Cl)cc1 to decrease its LogP value.,CCCCN(C[C@@H]1C=c2ccc(C)cc2=[NH+]C1=O)C(=O)c1ccc(Cl)cc1,1.2280199999999997
+148886,Optimize the molecule CC(C)C[C@H](C#N)NC(=O)Cc1ccc(Cl)cc1 to have a lower LogP value.,CC(C)C[C@H](C#N)NC(=O)Cc1ccc(Cl)cc1,2.936980000000001
+27113,Optimize the molecule C[C@]1(/C=N/O)CS/C(=N/O)S1 to have a lower LogP value.,C[C@]1(/C=N/O)CS/C(=N/O)S1,1.4303
+190409,Please modify the molecule C[C@@H](c1ccncc1)N1CCC([NH2+][C@H](C)c2ccc3c(c2)CCC3)CC1 to decrease its LogP value.,C[C@@H](c1ccncc1)N1CCC([NH2+][C@H](C)c2ccc3c(c2)CCC3)CC1,3.420300000000002
+149516,Modify the molecule O=c1nc(C(Cl)(Cl)Cl)nc2ccccn12 to increase its LogP value.,O=c1nc(C(Cl)(Cl)Cl)nc2ccccn12,1.9161999999999995
+2390,Optimize the molecule CC(C)C(=O)NC[C@@H]1CCCN(S(=O)(=O)CCC2CC2)C1 to have a lower LogP value.,CC(C)C(=O)NC[C@@H]1CCCN(S(=O)(=O)CCC2CC2)C1,1.6004999999999996
+15905,Please modify the molecule CCC[NH2+][C@@H](Cc1ncccc1C)c1ccc(Cl)cc1 to decrease its LogP value.,CCC[NH2+][C@@H](Cc1ncccc1C)c1ccc(Cl)cc1,3.300620000000002
+216432,Modify the molecule C[C@@H]1C[C@H]1C(=O)Nc1ccc(C(=O)NCc2ccccc2CO)cc1 to decrease its LogP value.,C[C@@H]1C[C@H]1C(=O)Nc1ccc(C(=O)NCc2ccccc2CO)cc1,2.703400000000001
+31297,Modify the molecule CC(C)(C)[C@@H](NCc1cc(=O)n2ccsc2[nH+]1)c1cccs1 to increase its LogP value.,CC(C)(C)[C@@H](NCc1cc(=O)n2ccsc2[nH+]1)c1cccs1,3.1136000000000017
+199264,Modify the molecule CC[C@H]1CN(Cc2cnc(C3CCC3)s2)CCS1 to increase its LogP value.,CC[C@H]1CN(Cc2cnc(C3CCC3)s2)CCS1,3.738000000000003
+34240,Please optimize the molecule O=C(Nc1ccccc1)C1CCN(C(=O)[C@H]2COc3ccccc3C2)CC1 to have a higher LogP value.,O=C(Nc1ccccc1)C1CCN(C(=O)[C@H]2COc3ccccc3C2)CC1,3.115000000000002
+226719,Please modify the molecule C[C@H]([NH2+]Cc1cccc2cccnc12)c1ccc(F)c(F)c1 to increase its LogP value.,C[C@H]([NH2+]Cc1cccc2cccnc12)c1ccc(F)c(F)c1,3.337600000000002
+60048,Optimize the molecule Cc1ccc(OCC(=O)NC2CCCCCC2)c(C[NH3+])n1 to have a higher LogP value.,Cc1ccc(OCC(=O)NC2CCCCCC2)c(C[NH3+])n1,1.3497199999999994
+247387,Modify the molecule CSc1ccccc1C(=O)NCc1ccc(-c2csc(C)n2)cc1 to increase its LogP value.,CSc1ccccc1C(=O)NCc1ccc(-c2csc(C)n2)cc1,4.770420000000004
+243299,Please optimize the molecule CC[NH2+][C@@H](Cc1ncccc1C)c1ccc(Br)c(F)c1 to have a lower LogP value.,CC[NH2+][C@@H](Cc1ncccc1C)c1ccc(Br)c(F)c1,3.1587200000000015
+69081,Please modify the molecule O=C(Cc1ccc(-n2cnnn2)cc1)N1CCc2ccc([N+](=O)[O-])cc2C1 to decrease its LogP value.,O=C(Cc1ccc(-n2cnnn2)cc1)N1CCc2ccc([N+](=O)[O-])cc2C1,1.6979
+101507,Modify the molecule Cc1nc(C2CCN(C(=O)NC[C@H](C(C)C)N3CC[NH+](C)CC3)CC2)no1 to increase its LogP value.,Cc1nc(C2CCN(C(=O)NC[C@H](C(C)C)N3CC[NH+](C)CC3)CC2)no1,0.12192000000000291
+144364,Modify the molecule CN(CC1=NC(=O)[C@H]2SC=CC2=N1)Cc1ccccc1F to increase its LogP value.,CN(CC1=NC(=O)[C@H]2SC=CC2=N1)Cc1ccccc1F,2.2663
+153714,Modify the molecule Cc1c(N2C(=O)[C@@H]3[C@H]4CCC[NH+]4[C@]4(C(=O)Nc5c(Cl)cccc54)[C@@H]3C2=O)cccc1[N+](=O)[O-] to have a higher LogP value.,Cc1c(N2C(=O)[C@@H]3[C@H]4CCC[NH+]4[C@]4(C(=O)Nc5c(Cl)cccc54)[C@@H]3C2=O)cccc1[N+](=O)[O-],1.5707200000000001
+191090,Please optimize the molecule CCOC(=O)[C@H]1[NH+]=c2ccc(F)cc2=C1NC(=O)CN1CCN(c2cccc(C)c2C)CC1 to have a lower LogP value.,CCOC(=O)[C@H]1[NH+]=c2ccc(F)cc2=C1NC(=O)CN1CCN(c2cccc(C)c2C)CC1,-0.8653599999999941
+247646,Modify the molecule CCn1cc([C@H](C)NC(=O)c2cc3c(C(F)(F)F)nn(C)c3s2)c(C)n1 to have a higher LogP value.,CCn1cc([C@H](C)NC(=O)c2cc3c(C(F)(F)F)nn(C)c3s2)c(C)n1,3.6694200000000023
+177627,Modify the molecule CC(C)CNC(=O)[C@@H](C)[S@](=O)c1cccc(F)c1 to increase its LogP value.,CC(C)CNC(=O)[C@@H](C)[S@](=O)c1cccc(F)c1,2.094
+227607,Optimize the molecule Fc1ccc(NC(=S)N(Cc2ccccc2)Cc2ccncc2)cc1Cl to have a higher LogP value.,Fc1ccc(NC(=S)N(Cc2ccccc2)Cc2ccncc2)cc1Cl,5.273300000000003
+186203,Please optimize the molecule COCCNC(=O)c1cccc(NC(=O)[C@@H]2CCCC[C@H]2C(=O)[O-])c1 to have a lower LogP value.,COCCNC(=O)c1cccc(NC(=O)[C@@H]2CCCC[C@H]2C(=O)[O-])c1,0.5576000000000003
+217795,Please optimize the molecule O[C@@H](Cc1ccncc1)Cc1nc2ccccc2s1 to have a higher LogP value.,O[C@@H](Cc1ccncc1)Cc1nc2ccccc2s1,2.8374000000000015
+24210,Modify the molecule C[C@]12CC[C@@]3(C)OCC(CO)(CO1)N23 to have a lower LogP value.,C[C@]12CC[C@@]3(C)OCC(CO)(CO1)N23,0.3061000000000001
+155263,Modify the molecule COCCCNC(=O)CN1C(=O)[C@@H]2CCCCN2c2ccc(C(=O)N(C)C)cc21 to increase its LogP value.,COCCCNC(=O)CN1C(=O)[C@@H]2CCCCN2c2ccc(C(=O)N(C)C)cc21,1.2466000000000015
+96770,Modify the molecule C[C@@]1(C(=O)[O-])CCCN1C(=O)NC[C@@]1(C)CCCO1 to increase its LogP value.,C[C@@]1(C(=O)[O-])CCCN1C(=O)NC[C@@]1(C)CCCO1,-0.13049999999999917
+115797,Please modify the molecule Cc1cc(C[S@@](=O)CC(=O)Nc2cccc(Cl)c2Cl)on1 to increase its LogP value.,Cc1cc(C[S@@](=O)CC(=O)Nc2cccc(Cl)c2Cl)on1,3.177220000000001
+342,Please modify the molecule CCc1nc2n(n1)CCC[C@H]2NC(=O)c1ccc(-n2cc(C)cn2)cc1 to increase its LogP value.,CCc1nc2n(n1)CCC[C@H]2NC(=O)c1ccc(-n2cc(C)cn2)cc1,2.599520000000001
+248639,Modify the molecule C[C@@H]([NH2+]CCN(C)C1CCCCC1)c1ccc2[nH]c(=O)[nH]c2c1 to have a higher LogP value.,C[C@@H]([NH2+]CCN(C)C1CCCCC1)c1ccc2[nH]c(=O)[nH]c2c1,1.745099999999999
+63423,Please modify the molecule Cc1nc(C[NH+]2CCC(Oc3ccnc(C(N)=O)c3)CC2)oc1C to decrease its LogP value.,Cc1nc(C[NH+]2CCC(Oc3ccnc(C(N)=O)c3)CC2)oc1C,0.41164000000000045
+38273,Optimize the molecule Cc1nc2cc(NC(=O)CNC(=O)c3sc4ccccc4c3Cl)ccc2o1 to have a higher LogP value.,Cc1nc2cc(NC(=O)CNC(=O)c3sc4ccccc4c3Cl)ccc2o1,4.372820000000003
+194805,Please modify the molecule COc1ccccc1CN(C(=O)Nc1ccc(SC)cc1)C1CC1 to decrease its LogP value.,COc1ccccc1CN(C(=O)Nc1ccc(SC)cc1)C1CC1,4.6136000000000035
+28080,Modify the molecule O=C(N[C@H]1CC[NH+](CC2CC2)C1)c1ccc(OCC(F)F)nc1 to have a lower LogP value.,O=C(N[C@H]1CC[NH+](CC2CC2)C1)c1ccc(OCC(F)F)nc1,0.5225000000000002
+10463,Modify the molecule COc1nc(C(=O)N(CCC(F)(F)F)C2CCCC2)cc2ccccc12 to increase its LogP value.,COc1nc(C(=O)N(CCC(F)(F)F)C2CCCC2)cc2ccccc12,4.580600000000004
+224104,Optimize the molecule CCOC(=O)c1nnnn1Cc1cccc(O)c1 to have a higher LogP value.,CCOC(=O)c1nnnn1Cc1cccc(O)c1,0.6036999999999995
+34351,Please optimize the molecule CCNc1ccc(C(=O)N2CC[NH+]3CCC[C@@H]3C2)cc1 to have a lower LogP value.,CCNc1ccc(C(=O)N2CC[NH+]3CCC[C@@H]3C2)cc1,0.6215000000000006
+144883,Modify the molecule CNC(=O)c1ccc(Cl)cc1NC(=O)CCNC(=O)[C@@H]1C[C@H]1C to increase its LogP value.,CNC(=O)c1ccc(Cl)cc1NC(=O)CCNC(=O)[C@@H]1C[C@H]1C,1.8003999999999998
+249084,Please optimize the molecule COc1ccccc1NC(=O)[C@@]1(c2ccccc2)CC1(Cl)Cl to have a higher LogP value.,COc1ccccc1NC(=O)[C@@]1(c2ccccc2)CC1(Cl)Cl,4.149300000000003
+146770,Modify the molecule C[C@](O)(CNC(=O)/C=C/c1ccc2c(c1)OCCO2)c1ccc(F)cc1 to increase its LogP value.,C[C@](O)(CNC(=O)/C=C/c1ccc2c(c1)OCCO2)c1ccc(F)cc1,2.6340000000000012
+176917,Optimize the molecule O=C1Nc2cc(S(=O)(=O)Nc3cccc4c3CCCC4)ccc2SC[C@H]1CC(=O)N1CCCC1 to have a lower LogP value.,O=C1Nc2cc(S(=O)(=O)Nc3cccc4c3CCCC4)ccc2SC[C@H]1CC(=O)N1CCCC1,4.039100000000003
+183900,Optimize the molecule COc1ccccc1COC1CCN(S(=O)(=O)CC#N)CC1 to have a higher LogP value.,COc1ccccc1COC1CCN(S(=O)(=O)CC#N)CC1,1.5295800000000002
+146586,Optimize the molecule O=C(NCCCc1cccc(F)c1)NOCc1ccccc1 to have a lower LogP value.,O=C(NCCCc1cccc(F)c1)NOCc1ccccc1,3.189300000000001
+207684,Modify the molecule COCCN1[C@H](C)C[NH+](Cc2ccc([S@](C)=O)cc2)C[C@H]1C to have a higher LogP value.,COCCN1[C@H](C)C[NH+](Cc2ccc([S@](C)=O)cc2)C[C@H]1C,0.5479000000000023
+21497,Please modify the molecule C[C@@H]([NH+](C)Cc1cnc(-c2ccccn2)s1)C1(C)CC1 to increase its LogP value.,C[C@@H]([NH+](C)Cc1cnc(-c2ccccn2)s1)C1(C)CC1,2.4084000000000003
+171857,Please optimize the molecule CCC(C)(C)c1nnc(NC(=O)c2ccc(NC(=O)Cc3ccccc3)cc2)s1 to have a lower LogP value.,CCC(C)(C)c1nnc(NC(=O)c2ccc(NC(=O)Cc3ccccc3)cc2)s1,4.659200000000004
+51084,Modify the molecule O=C(c1cccnc1OCC(F)F)N1CCO[C@@H](c2cccc(F)c2)C1 to increase its LogP value.,O=C(c1cccnc1OCC(F)F)N1CCO[C@@H](c2cccc(F)c2)C1,3.0783000000000014
+107680,Modify the molecule CCN1C[C@@]2(C(=O)[O-])CN(c3ccc(-c4ccccc4)nn3)C[C@H]2C1=O to have a higher LogP value.,CCN1C[C@@]2(C(=O)[O-])CN(c3ccc(-c4ccccc4)nn3)C[C@H]2C1=O,0.17819999999999991
+133968,Modify the molecule COC(=O)c1cccc(OC)c1OCc1cc(C)nc2ccccc12 to have a higher LogP value.,COC(=O)c1cccc(OC)c1OCc1cc(C)nc2ccccc12,3.9174200000000026
+23053,Please optimize the molecule Cn1cccc1[C@@H](CNC(=O)C(N)=O)N1CCc2ccccc2C1 to have a lower LogP value.,Cn1cccc1[C@@H](CNC(=O)C(N)=O)N1CCc2ccccc2C1,0.7260000000000006
+72558,Modify the molecule COc1ccc([C@H](C)NC(=O)c2cc(C)n(C3CC3)c2C)c(OC)c1 to decrease its LogP value.,COc1ccc([C@H](C)NC(=O)c2cc(C)n(C3CC3)c2C)c(OC)c1,3.9480400000000033
+90013,Modify the molecule C[C@@H](CC(=O)N1CCOC[C@H]1C(N)=O)Cc1ccc(Cl)cc1 to increase its LogP value.,C[C@@H](CC(=O)N1CCOC[C@H]1C(N)=O)Cc1ccc(Cl)cc1,1.6214000000000004
+126903,Optimize the molecule CC[C@@H]([NH3+])[C@H](SC1COC1)c1ccncc1 to have a lower LogP value.,CC[C@@H]([NH3+])[C@H](SC1COC1)c1ccncc1,1.2751999999999992
+50379,Optimize the molecule COc1c2c(cc3c1[C@H](CC(=O)[C@]1(C)CCOC1=O)[N+](C)(C)CC3)OCO2 to have a higher LogP value.,COc1c2c(cc3c1[C@H](CC(=O)[C@]1(C)CCOC1=O)[N+](C)(C)CC3)OCO2,2.009899999999999
+102265,Optimize the molecule CC[C@](C)([C@H](N)c1ccc(OC(C)C)cc1)[NH+]1CCCC1 to have a lower LogP value.,CC[C@](C)([C@H](N)c1ccc(OC(C)C)cc1)[NH+]1CCCC1,2.3209999999999997
+24225,Please optimize the molecule C[C@@H](CC(=O)N1CCN(S(=O)(=O)c2cccc(Cl)c2Cl)CC1)c1ccccc1 to have a lower LogP value.,C[C@@H](CC(=O)N1CCN(S(=O)(=O)c2cccc(Cl)c2Cl)CC1)c1ccccc1,4.020100000000003
+123529,Modify the molecule Cc1csc(Sc2ccc([N+](=O)[O-])cc2C(=O)OCc2cn3cc(Cl)ccc3n2)n1 to have a lower LogP value.,Cc1csc(Sc2ccc([N+](=O)[O-])cc2C(=O)OCc2cn3cc(Cl)ccc3n2)n1,5.169020000000003
+155489,Modify the molecule CSc1ccc(C(=O)N2CCC[C@@H](C#N)C2)cc1 to increase its LogP value.,CSc1ccc(C(=O)N2CCC[C@@H](C#N)C2)cc1,2.7842800000000016
+115473,Please optimize the molecule [NH3+]C1CC(NC(=O)[C@H]2CSc3ccccc32)C1 to have a higher LogP value.,[NH3+]C1CC(NC(=O)[C@H]2CSc3ccccc32)C1,0.7649999999999999
+200487,Please modify the molecule C[C@@H]1CCCN(C(=O)c2cccc(S(=O)(=O)N(Cc3ccccc3)c3ccccc3)c2)C1 to decrease its LogP value.,C[C@@H]1CCCN(C(=O)c2cccc(S(=O)(=O)N(Cc3ccccc3)c3ccccc3)c2)C1,4.954200000000005
+113109,Optimize the molecule C[C@@H]1CN(c2nc3ccccn3c2CC[NH3+])C[C@H]1C to have a higher LogP value.,C[C@@H]1CN(c2nc3ccccn3c2CC[NH3+])C[C@H]1C,1.2108999999999999
+212277,Please optimize the molecule CN1CCC[C@](O)(C[NH2+]Cc2c[nH]nc2-c2ccc(Cl)cc2)C1=O to have a higher LogP value.,CN1CCC[C@](O)(C[NH2+]Cc2c[nH]nc2-c2ccc(Cl)cc2)C1=O,0.7768000000000003
+145931,Please optimize the molecule O=C(/C=C(/c1ccc(Cl)cc1)C(F)(F)F)N(Cc1ccccc1O)C[C@@H]1CCCO1 to have a higher LogP value.,O=C(/C=C(/c1ccc(Cl)cc1)C(F)(F)F)N(Cc1ccccc1O)C[C@@H]1CCCO1,5.199100000000004
+183479,Modify the molecule COC[C@@H]1CCCC[C@H](Cl)C1 to increase its LogP value.,COC[C@@H]1CCCC[C@H](Cl)C1,2.820500000000001
+222957,Modify the molecule COc1ccccc1[C@H]1C[C@@H](C(F)F)n2ncc(C#N)c2N1 to have a lower LogP value.,COc1ccccc1[C@H]1C[C@@H](C(F)F)n2ncc(C#N)c2N1,3.126480000000001
+26875,Modify the molecule CC[NH+]1CC[C@H](N(C)CC(=O)Nc2c(C)nn(C)c2C)[C@H](C)C1 to increase its LogP value.,CC[NH+]1CC[C@H](N(C)CC(=O)Nc2c(C)nn(C)c2C)[C@H](C)C1,0.2204400000000024
+146566,Modify the molecule COc1cccc([C@H]2CN(Cc3cccc(O)c3)CCO2)c1 to have a lower LogP value.,COc1cccc([C@H]2CN(Cc3cccc(O)c3)CCO2)c1,2.9743000000000013
+175483,Modify the molecule CC(C)[C@@H]1C[C@@](O)(c2cscc2Br)CCO1 to decrease its LogP value.,CC(C)[C@@H]1C[C@@](O)(c2cscc2Br)CCO1,3.5332000000000026
+27951,Optimize the molecule CC(C)(Oc1ccc(Cl)cc1)C(=O)Nc1cc(-c2cccc([N+](=O)[O-])c2)n[nH]1 to have a higher LogP value.,CC(C)(Oc1ccc(Cl)cc1)C(=O)Nc1cc(-c2cccc([N+](=O)[O-])c2)n[nH]1,4.434400000000003
+111245,Please optimize the molecule COC[C@H](C)NC(=O)Nc1ccccc1OC to have a lower LogP value.,COC[C@H](C)NC(=O)Nc1ccccc1OC,1.8516
+244185,Please modify the molecule O=C(COc1ccccc1)Nc1ccc(OC[C@@H]2CCCO2)cc1 to increase its LogP value.,O=C(COc1ccccc1)Nc1ccc(OC[C@@H]2CCCO2)cc1,3.2619000000000016
+137739,Please optimize the molecule COc1ccc(Br)cc1S(=O)(=O)NCCCn1ccc2ccccc21 to have a lower LogP value.,COc1ccc(Br)cc1S(=O)(=O)NCCCn1ccc2ccccc21,3.7810000000000024
+150268,Please optimize the molecule CCc1cnc(CCNC(=O)N2CCN(C(=O)[C@@H]3C[C@H]3C)CC2)s1 to have a higher LogP value.,CCc1cnc(CCNC(=O)N2CCN(C(=O)[C@@H]3C[C@H]3C)CC2)s1,1.7577999999999998
+83607,Please modify the molecule Cc1ccccc1N1C(=N)S/C(=C\c2ccccc2OCC(=O)Nc2ccc(F)cc2)C1=O to decrease its LogP value.,Cc1ccccc1N1C(=N)S/C(=C\c2ccccc2OCC(=O)Nc2ccc(F)cc2)C1=O,5.207290000000004
+12628,Modify the molecule CC(C)Oc1ccc(C(=O)OCc2nc(C3CC3)cs2)cn1 to decrease its LogP value.,CC(C)Oc1ccc(C(=O)OCc2nc(C3CC3)cs2)cn1,3.559700000000002
+5577,Please optimize the molecule Cc1noc2nc(C3CCN(C(=O)COC[C@H]4CCCO4)CC3)cc(C(F)(F)F)c12 to have a lower LogP value.,Cc1noc2nc(C3CCN(C(=O)COC[C@H]4CCCO4)CC3)cc(C(F)(F)F)c12,3.451620000000002
+82886,Please optimize the molecule Cc1ccc(-c2csc(N3CCC[C@H](c4nncn4C(C)C)C3)n2)cc1 to have a lower LogP value.,Cc1ccc(-c2csc(N3CCC[C@H](c4nncn4C(C)C)C3)n2)cc1,4.674920000000004
+235561,Please modify the molecule COc1ccc(NC(=O)N(C)CCc2noc(-c3ccc(F)cc3)n2)cc1 to decrease its LogP value.,COc1ccc(NC(=O)N(C)CCc2noc(-c3ccc(F)cc3)n2)cc1,3.590700000000002
+246320,Please modify the molecule O=C(Nc1cccc(Cl)c1Cl)c1ccccc1N1CCCC1=O to decrease its LogP value.,O=C(Nc1cccc(Cl)c1Cl)c1ccccc1N1CCCC1=O,4.372500000000002
+233198,Please optimize the molecule Cc1ccccc1OCCN(C)C(=O)[C@H]1CCCCN1S(C)(=O)=O to have a lower LogP value.,Cc1ccccc1OCCN(C)C(=O)[C@H]1CCCCN1S(C)(=O)=O,1.6463200000000002
+192917,Modify the molecule Cc1cc(NC(=O)c2sc3ccccc3c2C)ccc1C(N)=O to have a higher LogP value.,Cc1cc(NC(=O)c2sc3ccccc3c2C)ccc1C(N)=O,3.869340000000001
+12724,Optimize the molecule CCCN(C)C(=O)[C@@H]1CC[C@@H]2CCCC[C@@H]2[NH2+]1 to have a lower LogP value.,CCCN(C)C(=O)[C@@H]1CC[C@@H]2CCCC[C@@H]2[NH2+]1,1.1394000000000004
+13242,Please modify the molecule CS[C@@H](C)c1cccc(NC(=O)CSCc2ccncc2)c1 to decrease its LogP value.,CS[C@@H](C)c1cccc(NC(=O)CSCc2ccncc2)c1,4.377500000000003
+175167,Optimize the molecule CC(C)=CC[NH+]1CCC2(CC[C@H](CNC(=O)c3cc(C)n(C)n3)O2)CC1 to have a lower LogP value.,CC(C)=CC[NH+]1CCC2(CC[C@H](CNC(=O)c3cc(C)n(C)n3)O2)CC1,1.0210200000000014
+217962,Optimize the molecule Cc1ccc(Cn2nc(C)c(C(=O)OCC(=O)N3CCC(C(N)=O)CC3)c2Cl)cc1 to have a higher LogP value.,Cc1ccc(Cn2nc(C)c(C(=O)OCC(=O)N3CCC(C(N)=O)CC3)c2Cl)cc1,2.08234
+197084,Modify the molecule C[C@H](c1cc2ccccc2o1)N(C)Cc1nnsc1Cl to decrease its LogP value.,C[C@H](c1cc2ccccc2o1)N(C)Cc1nnsc1Cl,4.130700000000003
+33110,Modify the molecule Cn1c(=O)oc2ccc(NC(=O)c3cc(F)ccc3O)cc21 to have a higher LogP value.,Cn1c(=O)oc2ccc(NC(=O)c3cc(F)ccc3O)cc21,2.2285000000000004
+68627,Please modify the molecule COC(=O)c1cnc(NC(=O)C2CCN(c3ncc(C(F)(F)F)cc3Cl)CC2)s1 to decrease its LogP value.,COC(=O)c1cnc(NC(=O)C2CCN(c3ncc(C(F)(F)F)cc3Cl)CC2)s1,3.852000000000002
+46226,Optimize the molecule O=C(CSc1nnc2ccc(-c3cccnc3)nn12)c1cccc([N+](=O)[O-])c1 to have a higher LogP value.,O=C(CSc1nnc2ccc(-c3cccnc3)nn12)c1cccc([N+](=O)[O-])c1,3.0695000000000014
+170395,Modify the molecule CCc1ccccc1CNC(=O)N[C@H](C)[C@H](CO)SC to have a lower LogP value.,CCc1ccccc1CNC(=O)N[C@H](C)[C@H](CO)SC,2.1605999999999996
+127247,Please optimize the molecule CCOc1ccc(C)cc1S(=O)(=O)Nc1ccc2c(c1)C(=O)N(CC)CCO2 to have a higher LogP value.,CCOc1ccc(C)cc1S(=O)(=O)Nc1ccc2c(c1)C(=O)N(CC)CCO2,3.0490200000000014
+231722,Optimize the molecule CCc1cccc2c1NC(=O)[C@]21[C@@H]2C(=O)N(c3ccccc3F)C(=O)[C@@H]2[C@@H]2CCC[NH+]21 to have a lower LogP value.,CCc1cccc2c1NC(=O)[C@]21[C@@H]2C(=O)N(c3ccccc3F)C(=O)[C@@H]2[C@@H]2CCC[NH+]21,1.4022
+245635,Modify the molecule CN1CCNC(=O)C12CC[NH+](Cc1cc(F)ccc1-n1cccn1)CC2 to have a higher LogP value.,CN1CCNC(=O)C12CC[NH+](Cc1cc(F)ccc1-n1cccn1)CC2,-0.009499999999998066
+54130,Modify the molecule CCC(CC)C1=CC(=O)CC(C)(C)C1 to have a higher LogP value.,CCC(CC)C1=CC(=O)CC(C)(C)C1,3.738100000000003
+141669,Modify the molecule N#Cc1cc(F)ccc1NC(=O)c1ccnc(OCC(F)F)c1 to decrease its LogP value.,N#Cc1cc(F)ccc1NC(=O)c1ccnc(OCC(F)F)c1,2.9885800000000007
+98175,Optimize the molecule O=C(N[C@H]1CCN(C(=O)c2nn(-c3ccccc3)c(=O)c3ncccc23)C1)c1ccccc1 to have a lower LogP value.,O=C(N[C@H]1CCN(C(=O)c2nn(-c3ccccc3)c(=O)c3ncccc23)C1)c1ccccc1,2.4251999999999994
+186900,Modify the molecule N#CCCN(Cc1ccco1)C(=O)c1cc(F)ccc1O to have a lower LogP value.,N#CCCN(Cc1ccco1)C(=O)c1cc(F)ccc1O,2.6803800000000018
+229983,Modify the molecule NC(=O)c1ccc(COc2ccc(I)cc2)c(F)c1 to decrease its LogP value.,NC(=O)c1ccc(COc2ccc(I)cc2)c(F)c1,3.108200000000002
+8946,Modify the molecule O=[N+]([O-])c1ccccc1N1CCN(Cc2nnc(-c3ccccc3Br)o2)CC1 to have a higher LogP value.,O=[N+]([O-])c1ccccc1N1CCN(Cc2nnc(-c3ccccc3Br)o2)CC1,3.7295000000000025
+37486,Please optimize the molecule CCC1CCC(NS(=O)(=O)c2cc(C(=O)OC)n(C)c2)CC1 to have a lower LogP value.,CCC1CCC(NS(=O)(=O)c2cc(C(=O)OC)n(C)c2)CC1,2.0587999999999997
+240361,Modify the molecule COC(=O)[C@@H](c1ccccc1)[NH+]1CCN(C/C=C/c2ccccc2)CC1 to have a lower LogP value.,COC(=O)[C@@H](c1ccccc1)[NH+]1CCN(C/C=C/c2ccccc2)CC1,1.8145999999999998
+235319,Modify the molecule Cc1ccc([C@@H]2c3cccn3CCN2C(=S)Nc2ccccc2)cc1 to have a higher LogP value.,Cc1ccc([C@@H]2c3cccn3CCN2C(=S)Nc2ccccc2)cc1,4.598520000000003
+219580,Modify the molecule Cc1cc(C(=O)NNC(=O)c2cc([N+](=O)[O-])ccc2N2CCC(C)CC2)c(C)o1 to increase its LogP value.,Cc1cc(C(=O)NNC(=O)c2cc([N+](=O)[O-])ccc2N2CCC(C)CC2)c(C)o1,3.1157400000000015
+130121,Modify the molecule Cc1cc(NCc2ccc(CN3CCCC3=O)cc2)[nH+]c2ccccc12 to increase its LogP value.,Cc1cc(NCc2ccc(CN3CCCC3=O)cc2)[nH+]c2ccccc12,3.6968200000000024
+38248,Please modify the molecule CCN[C@H]1CCC[NH+](C(C)C)C1 to decrease its LogP value.,CCN[C@H]1CCC[NH+](C(C)C)C1,0.051600000000000756
+213527,Modify the molecule Cc1cccc(Cl)c1NC(=O)c1ccc(-n2cncn2)c(F)c1 to decrease its LogP value.,Cc1cccc(Cl)c1NC(=O)c1ccc(-n2cncn2)c(F)c1,3.6205200000000017
+195139,Modify the molecule CC(C)N(C)C(=O)NCc1ccc(C(=O)N(C)C)cc1 to have a higher LogP value.,CC(C)N(C)C(=O)NCc1ccc(C(=O)N(C)C)cc1,1.9382000000000001
+106428,Please modify the molecule CCC[C@@H](C)[C@H]([NH2+]CC)C(C)C to decrease its LogP value.,CCC[C@@H](C)[C@H]([NH2+]CC)C(C)C,2.0304999999999995
+83645,Modify the molecule COc1cccc(-n2c(S)nnc2CSCc2ccc(F)cc2Cl)c1 to decrease its LogP value.,COc1cccc(-n2c(S)nnc2CSCc2ccc(F)cc2Cl)c1,4.790500000000002
+160249,Modify the molecule CCN(CC)C(=O)OCC[NH2+]C to have a lower LogP value.,CCN(CC)C(=O)OCC[NH2+]C,-0.3419999999999983
+38669,Modify the molecule CC(C)c1nn(C)c(Cl)c1CN1CCCN(c2ccccc2C#N)CC1 to have a higher LogP value.,CC(C)c1nn(C)c(Cl)c1CN1CCCN(c2ccccc2C#N)CC1,3.7808800000000033
+43423,Modify the molecule C[C@H]([C@@H](C)S(C)(=O)=O)N(C)C(=O)C/C=C/c1ccc(F)cc1 to decrease its LogP value.,C[C@H]([C@@H](C)S(C)(=O)=O)N(C)C(=O)C/C=C/c1ccc(F)cc1,2.5090000000000003
+149310,Modify the molecule COc1cc(NCc2ccc(Cl)s2)cc(OC)c1OC to have a higher LogP value.,COc1cc(NCc2ccc(Cl)s2)cc(OC)c1OC,4.039400000000003
+59477,Please optimize the molecule C=CCSc1ncnc2c1sc1nc(N3CCOCC3)c3c(c12)CCCC3 to have a lower LogP value.,C=CCSc1ncnc2c1sc1nc(N3CCOCC3)c3c(c12)CCCC3,4.233000000000003
+192372,Please optimize the molecule O=C(Cl)c1ccc2sccc2c1 to have a higher LogP value.,O=C(Cl)c1ccc2sccc2c1,3.2803000000000013
+10005,Please modify the molecule COc1ccccc1OCCn1c(-c2ccccc2)noc1=O to increase its LogP value.,COc1ccccc1OCCn1c(-c2ccccc2)noc1=O,2.5909000000000004
+22629,Modify the molecule CC[C@@H]1CCCCN1S(=O)(=O)c1ccc(N2C(=O)CCCC2=O)cc1 to increase its LogP value.,CC[C@@H]1CCCCN1S(=O)(=O)c1ccc(N2C(=O)CCCC2=O)cc1,2.683300000000001
+91069,Please optimize the molecule C[C@H]1CCCC[C@@H]1NC(=O)NC[C@H](O)c1c(F)cccc1F to have a higher LogP value.,C[C@H]1CCCC[C@@H]1NC(=O)NC[C@H](O)c1c(F)cccc1F,2.876100000000001
+135590,Modify the molecule O=C(NCc1ccc(F)cc1)c1cc(S(=O)(=O)N2CCCC2)ccc1Cl to decrease its LogP value.,O=C(NCc1ccc(F)cc1)c1cc(S(=O)(=O)N2CCCC2)ccc1Cl,3.1936000000000018
+136657,Please modify the molecule COC(C)(C)c1noc([C@H]2CCCN(C(=O)c3cc(C)cc(C)c3)C2)n1 to increase its LogP value.,COC(C)(C)c1noc([C@H]2CCCN(C(=O)c3cc(C)cc(C)c3)C2)n1,3.587740000000003
+127533,Please optimize the molecule Cc1ccc(C)c(C(=O)OCc2nc(-c3cccc(Cl)c3)no2)c1 to have a higher LogP value.,Cc1ccc(C)c(C(=O)OCc2nc(-c3cccc(Cl)c3)no2)c1,4.363840000000003
+7354,Please optimize the molecule CC(=O)Nc1c(C)cc(NC(=O)c2cc(C)nc3c2c(=O)[nH]n3C)cc1C to have a lower LogP value.,CC(=O)Nc1c(C)cc(NC(=O)c2cc(C)nc3c2c(=O)[nH]n3C)cc1C,2.3975600000000004
+8086,Modify the molecule COc1ccc(CCNC(=O)CN2C(=O)c3cccc4cccc(c34)C2=O)cc1OC to increase its LogP value.,COc1ccc(CCNC(=O)CN2C(=O)c3cccc4cccc(c34)C2=O)cc1OC,2.8119000000000005
+213421,Optimize the molecule CNc1cccc(CN(C)c2ccccc2OC)[nH+]1 to have a higher LogP value.,CNc1cccc(CN(C)c2ccccc2OC)[nH+]1,2.1874
+73152,Modify the molecule CN(C)C(=O)Nc1cccc(C(=O)N2CCSC3(CCCCC3)C2)c1 to decrease its LogP value.,CN(C)C(=O)Nc1cccc(C(=O)N2CCSC3(CCCCC3)C2)c1,3.6720000000000033
+62929,Modify the molecule Cc1noc(C)c1CCCNC(=O)N1CCOC[C@H]1CC(C)C to increase its LogP value.,Cc1noc(C)c1CCCNC(=O)N1CCOC[C@H]1CC(C)C,2.6805400000000006
+94961,Please optimize the molecule Cc1ccc(C)c(NC(=O)OC2CCCCC2)c1 to have a higher LogP value.,Cc1ccc(C)c(NC(=O)OC2CCCCC2)c1,4.184640000000003
+15294,Optimize the molecule COCCc1nc(C)c([C@H](C)[NH2+][C@H]2[C@@H]3CCO[C@@H]3C2(C)C)s1 to have a higher LogP value.,COCCc1nc(C)c([C@H](C)[NH2+][C@H]2[C@@H]3CCO[C@@H]3C2(C)C)s1,2.07832
+2704,Optimize the molecule COc1ccc(OC)c(N2CC(=O)C(c3nc4ccccc4s3)=C2N)c1 to have a lower LogP value.,COc1ccc(OC)c(N2CC(=O)C(c3nc4ccccc4s3)=C2N)c1,3.030100000000001
+232572,Modify the molecule C[C@H](NC(=O)N1CCN(c2ccc(F)cn2)CC1)c1ccccc1Cl to increase its LogP value.,C[C@H](NC(=O)N1CCN(c2ccc(F)cn2)CC1)c1ccccc1Cl,3.4669000000000025
+201650,Optimize the molecule CCOC(=O)[C@H](C)CSC1COC1 to have a lower LogP value.,CCOC(=O)[C@H](C)CSC1COC1,1.3176
+92989,Please modify the molecule CC[C@@](C)(NC(=O)c1sc2cc(F)ccc2c1Cl)C(=O)[O-] to increase its LogP value.,CC[C@@](C)(NC(=O)c1sc2cc(F)ccc2c1Cl)C(=O)[O-],2.342200000000001
+182481,Modify the molecule Cc1ccc(-n2nc(C)c3c(C)c(CCC(=O)NCc4ccccc4)c(C)nc32)cc1 to have a lower LogP value.,Cc1ccc(-n2nc(C)c3c(C)c(CCC(=O)NCc4ccccc4)c(C)nc32)cc1,4.903180000000004
+3356,Modify the molecule CCc1ccc(C2=C[C@@H]3C(=O)N=N[C@H](SCC(=O)c4ccc5c(c4)OCO5)N3N2)cc1 to have a higher LogP value.,CCc1ccc(C2=C[C@@H]3C(=O)N=N[C@H](SCC(=O)c4ccc5c(c4)OCO5)N3N2)cc1,3.3995000000000015
+179013,Please modify the molecule CC(C)c1nc(C[NH+]2CC[C@@H]3[C@@H](CCC(=O)N3CCC[NH3+])C2)co1 to increase its LogP value.,CC(C)c1nc(C[NH+]2CC[C@@H]3[C@@H](CCC(=O)N3CCC[NH3+])C2)co1,-0.1741999999999968
+193093,Optimize the molecule CSc1ccc2c(c1)CCC[C@H]2[NH2+][C@H]1CCCn2nc(C)nc21 to have a higher LogP value.,CSc1ccc2c(c1)CCC[C@H]2[NH2+][C@H]1CCCn2nc(C)nc21,2.784320000000001
+182533,Optimize the molecule CCC[C@H]([NH3+])CCC[C@H]1COc2ccccc21 to have a higher LogP value.,CCC[C@H]([NH3+])CCC[C@H]1COc2ccccc21,2.743500000000001
+225359,Modify the molecule C[C@@H](CC(=O)[C@H](C#N)c1nc(N)nc(Nc2ccccc2)n1)c1ccccc1 to increase its LogP value.,C[C@@H](CC(=O)[C@H](C#N)c1nc(N)nc(Nc2ccccc2)n1)c1ccccc1,3.5674800000000015
+169166,Modify the molecule COc1ccc([C@@H]2[NH+]=N/C(=N\C(=O)Cc3ccccc3)S2)cc1OC to have a higher LogP value.,COc1ccc([C@@H]2[NH+]=N/C(=N\C(=O)Cc3ccccc3)S2)cc1OC,2.1072999999999995
+103945,Modify the molecule Cc1ncc(CO/N=C(/N)Cc2cccnc2)s1 to have a lower LogP value.,Cc1ncc(CO/N=C(/N)Cc2cccnc2)s1,1.8780199999999998
+107850,Please optimize the molecule CCc1nnc(SCC(=O)NNC(=O)COC)n1N to have a higher LogP value.,CCc1nnc(SCC(=O)NNC(=O)COC)n1N,-1.5597999999999976
+181466,Please modify the molecule c1ccc2c(c1)CC1(CC[NH2+]CC1)C2 to decrease its LogP value.,c1ccc2c(c1)CC1(CC[NH2+]CC1)C2,1.1287999999999998
+109588,Modify the molecule CC1(C)C[C@](C)(c2ccccc2)c2ccccc2N1C(=O)CN1C(=O)[C@H]2CCCC[C@@H]2C1=O to decrease its LogP value.,CC1(C)C[C@](C)(c2ccccc2)c2ccccc2N1C(=O)CN1C(=O)[C@H]2CCCC[C@@H]2C1=O,4.683100000000004
+2824,Modify the molecule CCC[C@@H]1CN(C(=O)[C@H](c2ccccc2)N(C)CC)CCO1 to have a lower LogP value.,CCC[C@@H]1CN(C(=O)[C@H](c2ccccc2)N(C)CC)CCO1,2.706900000000001
+23638,Optimize the molecule NC(=O)C1CCC(CNC(=O)CCC(=O)c2ccc3c(c2)CCCC3)CC1 to have a higher LogP value.,NC(=O)C1CCC(CNC(=O)CCC(=O)c2ccc3c(c2)CCCC3)CC1,2.9361999999999995
+213340,Please modify the molecule CCCN(Cc1ccccc1)C(=O)c1cc2ccccc2oc1=O to decrease its LogP value.,CCCN(Cc1ccccc1)C(=O)c1cc2ccccc2oc1=O,3.8454000000000033
+55438,Optimize the molecule Cc1cccc([C@H](CNC(=O)c2ccc(-n3cnc4ccccc43)cc2)N2CCOCC2)c1 to have a higher LogP value.,Cc1cccc([C@H](CNC(=O)c2ccc(-n3cnc4ccccc43)cc2)N2CCOCC2)c1,4.137220000000003
+38958,Modify the molecule CC(C)[C@@H](Sc1nnc(N)s1)C(=O)N[C@@H]1CCCC[C@H]1C to have a higher LogP value.,CC(C)[C@@H](Sc1nnc(N)s1)C(=O)N[C@@H]1CCCC[C@H]1C,2.9319000000000015
+71622,Modify the molecule CCc1nnc(C[NH+]2CC[C@H](Nc3ccccc3)C2)o1 to have a higher LogP value.,CCc1nnc(C[NH+]2CC[C@H](Nc3ccccc3)C2)o1,0.9013
+89896,Modify the molecule C/[NH+]=C(/NCC1([NH+](C)C)CCOCC1)N1CC[C@@H]([NH+]2CCCC2)C1 to increase its LogP value.,C/[NH+]=C(/NCC1([NH+](C)C)CCOCC1)N1CC[C@@H]([NH+]2CCCC2)C1,-3.9108999999999963
+227692,Please optimize the molecule Cn1cc(Br)cc1C(=O)Nc1cccc(N2CCCC2=O)c1 to have a higher LogP value.,Cn1cc(Br)cc1C(=O)Nc1cccc(N2CCCC2=O)c1,3.1667000000000014
+95108,Please optimize the molecule COc1cc(C(=O)Nc2ccc3c(c2)NC(=O)[C@@H](C)O3)cc2c1OCCO2 to have a lower LogP value.,COc1cc(C(=O)Nc2ccc3c(c2)NC(=O)[C@@H](C)O3)cc2c1OCCO2,2.4381000000000004
+10479,Optimize the molecule O=C(Nc1ccc2c(c1)OCCO2)[C@H]1CC(=O)N(CCC2=c3cc(Cl)ccc3=[NH+]C2)C1 to have a higher LogP value.,O=C(Nc1ccc2c(c1)OCCO2)[C@H]1CC(=O)N(CCC2=c3cc(Cl)ccc3=[NH+]C2)C1,-0.1469999999999989
+177264,Please optimize the molecule C[C@H]1CC(C)(C)C[C@]2(C1)NC(=O)N(CC(=O)OC1CCCCC1)C2=O to have a higher LogP value.,C[C@H]1CC(C)(C)C[C@]2(C1)NC(=O)N(CC(=O)OC1CCCCC1)C2=O,2.999100000000002
+112269,Optimize the molecule CCOCc1ccccc1NC(=O)C(=O)NC[C@@H]1CCC[C@@H](O)C1 to have a lower LogP value.,CCOCc1ccccc1NC(=O)C(=O)NC[C@@H]1CCC[C@@H](O)C1,1.8289
+22527,Optimize the molecule CCOc1cc2c(cc1OCC)[C@@H](c1ccc(OC)c3ccccc13)[NH2+]CC2 to have a higher LogP value.,CCOc1cc2c(cc1OCC)[C@@H](c1ccc(OC)c3ccccc13)[NH2+]CC2,3.854700000000001
+122386,Please modify the molecule Cc1ccc(C)n1-c1ccc(C(=O)N2CCC(Cc3ccccc3)CC2)cc1 to decrease its LogP value.,Cc1ccc(C)n1-c1ccc(C(=O)N2CCC(Cc3ccccc3)CC2)cc1,5.189040000000005
+25867,Please optimize the molecule COc1ccc(CC(=O)N/N=C\c2ccc(N(C)C)cc2)cc1OC to have a higher LogP value.,COc1ccc(CC(=O)N/N=C\c2ccc(N(C)C)cc2)cc1OC,2.4626
+170801,Modify the molecule COC(=O)N1CC[C@@H]([NH2+][C@H](C)c2cc(C)sc2C)C1 to have a lower LogP value.,COC(=O)N1CC[C@@H]([NH2+][C@H](C)c2cc(C)sc2C)C1,1.8300400000000003
+103351,Please optimize the molecule C[C@H]([NH2+]C1CCN([C@H](C)c2ccncc2)CC1)C1CCCCC1 to have a higher LogP value.,C[C@H]([NH2+]C1CCN([C@H](C)c2ccncc2)CC1)C1CCCCC1,3.1392000000000015
+76575,Modify the molecule CN(Cc1ccccc1Br)S(=O)(=O)c1ccc(Br)cc1 to have a lower LogP value.,CN(Cc1ccccc1Br)S(=O)(=O)c1ccc(Br)cc1,4.032300000000003
+177399,Modify the molecule Cc1ccc(/C=C2\SC(=S)N(CCN3CCOCC3)C2=O)c(C)c1 to have a higher LogP value.,Cc1ccc(/C=C2\SC(=S)N(CCN3CCOCC3)C2=O)c(C)c1,2.8368400000000005
+216456,Modify the molecule CCOc1ccc([C@H](C)NC(=O)Nc2ccc3c(c2)OCCCO3)cc1 to have a lower LogP value.,CCOc1ccc([C@H](C)NC(=O)Nc2ccc3c(c2)OCCCO3)cc1,4.129300000000002
+234056,Please modify the molecule CCCOc1ccc(C(=O)Nc2ccccc2C(=O)NCC)cc1 to increase its LogP value.,CCCOc1ccc(C(=O)Nc2ccccc2C(=O)NCC)cc1,3.477400000000002
+67878,Please optimize the molecule COc1ccccc1-c1nnc(SCC(=O)Nc2ccc3c(c2)OCCO3)o1 to have a lower LogP value.,COc1ccccc1-c1nnc(SCC(=O)Nc2ccc3c(c2)OCCO3)o1,3.247200000000001
+241330,Please modify the molecule CC(C)CNc1cnn(-c2ncccn2)c1 to increase its LogP value.,CC(C)CNc1cnn(-c2ncccn2)c1,1.7301999999999997
+87941,Please modify the molecule C[C@H]1CCCC[C@H]1OCC(=O)Nc1ccc2c(c1)CCCC(=O)N2 to decrease its LogP value.,C[C@H]1CCCC[C@H]1OCC(=O)Nc1ccc2c(c1)CCCC(=O)N2,3.4952000000000023
+18414,Modify the molecule Cc1ccc(NC(=O)/C=C/c2ccc([N+](=O)[O-])cc2)cc1S(=O)(=O)N1CCCCC1 to decrease its LogP value.,Cc1ccc(NC(=O)/C=C/c2ccc([N+](=O)[O-])cc2)cc1S(=O)(=O)N1CCCCC1,3.729720000000003
+117688,Please modify the molecule CCOC(=O)C1=C(CN2C[C@@H](C)C[C@H](C)C2)NC(=O)N[C@@H]1c1ccc(Cl)cc1 to decrease its LogP value.,CCOC(=O)C1=C(CN2C[C@@H](C)C[C@H](C)C2)NC(=O)N[C@@H]1c1ccc(Cl)cc1,3.4890000000000017
+52487,Modify the molecule Cn1nc2n(c1=O)CC[NH+](Cc1nc(CCc3ccccc3)no1)C2 to increase its LogP value.,Cn1nc2n(c1=O)CC[NH+](Cc1nc(CCc3ccccc3)no1)C2,-0.651299999999998
+209004,Optimize the molecule CS[C@@H]1CCC[C@H](NC(=O)c2cc(C#N)cs2)C1 to have a higher LogP value.,CS[C@@H]1CCC[C@H](NC(=O)c2cc(C#N)cs2)C1,3.0237800000000012
+3542,Please modify the molecule CCC(CC)[C@@H](C(=O)OC)C(=O)C(C)C to increase its LogP value.,CCC(CC)[C@@H](C(=O)OC)C(=O)C(C)C,2.4369000000000005
+44241,Please modify the molecule C#CCN(CC1CC1)C(=O)c1cccc(OCC(F)F)n1 to decrease its LogP value.,C#CCN(CC1CC1)C(=O)c1cccc(OCC(F)F)n1,2.2109000000000005
+165755,Optimize the molecule COc1ccc(-c2cc(CN(C)S(=O)(=O)c3ccc(Cl)cc3C(F)(F)F)on2)cc1 to have a higher LogP value.,COc1ccc(-c2cc(CN(C)S(=O)(=O)c3ccc(Cl)cc3C(F)(F)F)on2)cc1,4.843100000000003
+178168,Optimize the molecule CN[C@@H]1C(=O)Nc2cc(Oc3ccccc3Cl)c(Cl)cc21 to have a higher LogP value.,CN[C@@H]1C(=O)Nc2cc(Oc3ccccc3Cl)c(Cl)cc21,3.998300000000002
+127092,Optimize the molecule CCN[C@@]1(C(=O)OCC)CCC[C@H](N2CCO[C@H](C)C2)C1 to have a higher LogP value.,CCN[C@@]1(C(=O)OCC)CCC[C@H](N2CCO[C@H](C)C2)C1,1.5610999999999997
+220512,Please optimize the molecule CCN(CC)c1ncnc2sc(C)cc12 to have a lower LogP value.,CCN(CC)c1ncnc2sc(C)cc12,2.8459200000000013
+18379,Modify the molecule Cc1ncc([C@@H](C)N[C@@H]2CCCN(c3cccnn3)C2)s1 to decrease its LogP value.,Cc1ncc([C@@H](C)N[C@@H]2CCCN(c3cccnn3)C2)s1,2.5611200000000007
+106013,Modify the molecule NC(=O)c1cc2cc(F)ccc2nc1C1CCN(C(=O)CN[C@H]2C=CS(=O)(=O)C2)CC1 to have a lower LogP value.,NC(=O)c1cc2cc(F)ccc2nc1C1CCN(C(=O)CN[C@H]2C=CS(=O)(=O)C2)CC1,1.0791
+37337,Please modify the molecule CC(=O)NC1(C#N)CCCC1 to decrease its LogP value.,CC(=O)NC1(C#N)CCCC1,0.95888
+223083,Modify the molecule COc1ccc(C[NH+]2CCN(c3cc(Cl)nc(N)n3)CC2)cc1 to increase its LogP value.,COc1ccc(C[NH+]2CCN(c3cc(Cl)nc(N)n3)CC2)cc1,0.6259000000000005
+239509,Please modify the molecule COc1ccc(C)cc1[C@@](C)(O)C1(C)CC1 to decrease its LogP value.,COc1ccc(C)cc1[C@@](C)(O)C1(C)CC1,3.0112200000000016
+221769,Modify the molecule Cc1ccc(C(=O)NCCc2ccc(F)cc2)s1 to have a lower LogP value.,Cc1ccc(C(=O)NCCc2ccc(F)cc2)s1,3.168120000000002
+45248,Modify the molecule Cc1ccccc1[C@@H](CC(=O)NCCC(=O)N1CCCC1)NC(N)=O to have a higher LogP value.,Cc1ccccc1[C@@H](CC(=O)NCCC(=O)N1CCCC1)NC(N)=O,1.2232200000000004
+227242,Please optimize the molecule CSCC[C@@H](C(=O)Nc1nccs1)N1C(=O)c2ccccc2C1=O to have a higher LogP value.,CSCC[C@@H](C(=O)Nc1nccs1)N1C(=O)c2ccccc2C1=O,2.4995000000000003
+244668,Optimize the molecule CCc1ccc(-n2c(CN3CCN(S(=O)(=O)c4ccccc4)CC3)[nH+]c3cccnc32)cc1 to have a higher LogP value.,CCc1ccc(-n2c(CN3CCN(S(=O)(=O)c4ccccc4)CC3)[nH+]c3cccnc32)cc1,2.908500000000001
+152761,Please modify the molecule N#Cc1ccc(OCCNC(=O)NC[C@@H](O)c2ccco2)cc1 to increase its LogP value.,N#Cc1ccc(OCCNC(=O)NC[C@@H](O)c2ccco2)cc1,1.5628799999999998
+144801,Please modify the molecule [NH3+][C@H]1CC[C@@H]([NH+]2CCC(C[NH+]3CCCC3)CC2)C1 to increase its LogP value.,[NH3+][C@H]1CC[C@@H]([NH+]2CCC(C[NH+]3CCCC3)CC2)C1,-1.8769999999999958
+21704,Please optimize the molecule COc1ccc(C=O)cc1OCC(=O)NC1CCC(C)CC1 to have a higher LogP value.,COc1ccc(C=O)cc1OCC(=O)NC1CCC(C)CC1,2.5814000000000004
+89957,Modify the molecule COc1ccc(Cl)c(NC(=O)NCc2cc[nH+]c(N(C)C)c2)c1 to increase its LogP value.,COc1ccc(Cl)c(NC(=O)NCc2cc[nH+]c(N(C)C)c2)c1,2.5504000000000007
+33826,Please modify the molecule O=C1C[C@H](Nc2ccc(Br)c([N+](=O)[O-])c2)CCCN1 to increase its LogP value.,O=C1C[C@H](Nc2ccc(Br)c([N+](=O)[O-])c2)CCCN1,2.4379
+39228,Please optimize the molecule c1ccc(N2CCC([NH2+]Cc3ccccc3OC3CCC3)CC2)[nH+]c1 to have a higher LogP value.,c1ccc(N2CCC([NH2+]Cc3ccccc3OC3CCC3)CC2)[nH+]c1,2.1643999999999997
+6691,Please optimize the molecule Cc1nn(C)cc1-c1cc(C(F)F)c2c(C(C)C)nn(-c3ccc(F)cc3)c2n1 to have a higher LogP value.,Cc1nn(C)cc1-c1cc(C(F)F)c2c(C(C)C)nn(-c3ccc(F)cc3)c2n1,5.329520000000004
+196853,Optimize the molecule Nc1cccc2oc(Nc3cc(Cl)ccc3F)nc12 to have a higher LogP value.,Nc1cccc2oc(Nc3cc(Cl)ccc3F)nc12,3.9461000000000013
+97443,Modify the molecule O=C(NCCO)c1ccccc1O to have a lower LogP value.,O=C(NCCO)c1ccccc1O,0.11430000000000001
+120284,Modify the molecule CC(=O)N1CCN(C(=O)C(=O)Nc2c(C)nn(-c3ccccc3)c2C)CC1 to have a lower LogP value.,CC(=O)N1CCN(C(=O)C(=O)Nc2c(C)nn(-c3ccccc3)c2C)CC1,1.1183399999999994
+50719,Modify the molecule CC[C@H](O)CCNC(=O)Nc1ccc(C(C)=O)c(C)c1 to have a lower LogP value.,CC[C@H](O)CCNC(=O)Nc1ccc(C(C)=O)c(C)c1,2.4801200000000003
+89135,Please modify the molecule O=c1[nH]c([O-])nnc1Nn1cccc1 to decrease its LogP value.,O=c1[nH]c([O-])nnc1Nn1cccc1,-1.0848
+653,Modify the molecule COc1ccccc1N1CC[NH+]([C@@H](C)C(=O)Nc2ccc(F)cc2)CC1 to decrease its LogP value.,COc1ccccc1N1CC[NH+]([C@@H](C)C(=O)Nc2ccc(F)cc2)CC1,1.5663999999999993
+113219,Please modify the molecule Cc1cccc(COc2cccc(C(=O)Nc3ncccc3O)c2)c1 to decrease its LogP value.,Cc1cccc(COc2cccc(C(=O)Nc3ncccc3O)c2)c1,3.9269200000000017
+63569,Please optimize the molecule CC[NH+](CC)CCCN1C(=O)c2oc3ccc(Cl)cc3c(=O)c2[C@H]1c1ccc(O)cc1 to have a higher LogP value.,CC[NH+](CC)CCCN1C(=O)c2oc3ccc(Cl)cc3c(=O)c2[C@H]1c1ccc(O)cc1,3.0120000000000013
+162613,Modify the molecule N#C/C(=C\c1ccc2c(c1)OCO2)C(=O)Nc1ccc(-c2nnc3n2CCCCC3)cc1 to decrease its LogP value.,N#C/C(=C\c1ccc2c(c1)OCO2)C(=O)Nc1ccc(-c2nnc3n2CCCCC3)cc1,3.9458800000000025
+110977,Please modify the molecule CCCCOC(=O)C1=C(C)Nc2nnnn2[C@H]1c1ccc(O)c(OC)c1 to increase its LogP value.,CCCCOC(=O)C1=C(C)Nc2nnnn2[C@H]1c1ccc(O)c(OC)c1,2.0194999999999994
+167790,Optimize the molecule C[C@H](NC(=O)C1CCN(S(=O)(=O)c2ccc3c(c2)OCCO3)CC1)c1ccc(Cl)c(Cl)c1 to have a lower LogP value.,C[C@H](NC(=O)C1CCN(S(=O)(=O)c2ccc3c(c2)OCCO3)CC1)c1ccc(Cl)c(Cl)c1,4.0427000000000035
+139670,Please modify the molecule C[C@H](Sc1nc(-c2ccc(Cl)cc2)n[nH]1)C(=O)NCc1ccco1 to decrease its LogP value.,C[C@H](Sc1nc(-c2ccc(Cl)cc2)n[nH]1)C(=O)NCc1ccco1,3.5151000000000012
+39137,Please modify the molecule CC(=O)N(c1nc(CSc2ncn[nH]2)cs1)c1c(C)cc(C)cc1C to decrease its LogP value.,CC(=O)N(c1nc(CSc2ncn[nH]2)cs1)c1c(C)cc(C)cc1C,4.163360000000003
+148233,Optimize the molecule CN[C@@H](c1c[nH+]ccc1N)C1([NH+](C)C)CCCCCC1 to have a higher LogP value.,CN[C@@H](c1c[nH+]ccc1N)C1([NH+](C)C)CCCCCC1,0.5809000000000002
+117975,Modify the molecule COC(=O)c1ccc(COCC[C@@H]2CCCC[NH2+]2)cc1 to have a lower LogP value.,COC(=O)c1ccc(COCC[C@@H]2CCCC[NH2+]2)cc1,1.4957999999999998
+213668,Modify the molecule Cc1cc2n(n1)CCC(=O)N2[C@@H](C)C(=O)NCc1ccccn1 to have a higher LogP value.,Cc1cc2n(n1)CCC(=O)N2[C@@H](C)C(=O)NCc1ccccn1,1.028119999999999
+96842,Please modify the molecule O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc(-c2cccs2)on1 to increase its LogP value.,O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc(-c2cccs2)on1,4.349300000000004
+240595,Modify the molecule O=C1c2cnc3[nH]nc(-c4ccccc4)c3c2C(=O)N1Cc1ccccc1 to have a higher LogP value.,O=C1c2cnc3[nH]nc(-c4ccccc4)c3c2C(=O)N1Cc1ccccc1,3.421100000000002
+144584,Modify the molecule COCCN(C(=O)NCCC1CCCC1)[C@@H]1CCS(=O)(=O)C1 to have a lower LogP value.,COCCN(C(=O)NCCC1CCCC1)[C@@H]1CCS(=O)(=O)C1,1.4118
+19376,Modify the molecule CC(=O)c1ccc(C(=O)Nc2ccc3c(c2)Cc2ccccc2-3)s1 to decrease its LogP value.,CC(=O)c1ccc(C(=O)Nc2ccc3c(c2)Cc2ccccc2-3)s1,4.774200000000002
+96220,Please modify the molecule O=C(Cc1cc(Cl)c2c(c1)OCCCO2)OCc1cn2cc(Cl)ccc2n1 to decrease its LogP value.,O=C(Cc1cc(Cl)c2c(c1)OCCCO2)OCc1cn2cc(Cl)ccc2n1,4.088300000000003
+198921,Modify the molecule CSc1ccc(CCNC(=O)[C@@H]2CCCN(c3nc4cc(Br)ccc4[nH]3)C2)cc1 to have a lower LogP value.,CSc1ccc(CCNC(=O)[C@@H]2CCCN(c3nc4cc(Br)ccc4[nH]3)C2)cc1,4.622600000000003
+91495,Please modify the molecule O=C(c1cnoc1-c1ccccc1)N1CCOC[C@H](O)C1 to decrease its LogP value.,O=C(c1cnoc1-c1ccccc1)N1CCOC[C@H](O)C1,1.1748999999999998
+101664,Please optimize the molecule CCn1ccnc(Nc2cc(OC)c(OC)cc2C)c1=O to have a higher LogP value.,CCn1ccnc(Nc2cc(OC)c(OC)cc2C)c1=O,2.33242
+131162,Optimize the molecule Cc1ccc([C@@H](C)NCc2nc(C3CC3)cs2)cc1C to have a lower LogP value.,Cc1ccc([C@@H](C)NCc2nc(C3CC3)cs2)cc1C,4.488140000000004
+185851,Modify the molecule CCOC(=O)c1c(NC(=O)/C(C#N)=C/c2ccccc2F)sc2c1CCCC2 to have a lower LogP value.,CCOC(=O)c1c(NC(=O)/C(C#N)=C/c2ccccc2F)sc2c1CCCC2,4.488380000000004
+31980,Please optimize the molecule CC[C@@H](C#N)S(=O)(=O)NCC1C(C)(C)C1(C)C to have a lower LogP value.,CC[C@@H](C#N)S(=O)(=O)NCC1C(C)(C)C1(C)C,1.89018
+216251,Please modify the molecule CC[C@@H]1CN(C)c2ccccc2CN1C(=O)Nc1ccc(OC)c(OC)c1 to increase its LogP value.,CC[C@@H]1CN(C)c2ccccc2CN1C(=O)Nc1ccc(OC)c(OC)c1,3.966300000000003
+96651,Optimize the molecule CCC[NH+](Cc1ccccc1)Cc1cc(Cl)ccc1N to have a lower LogP value.,CCC[NH+](Cc1ccccc1)Cc1cc(Cl)ccc1N,2.9173
+91366,Modify the molecule Cc1ccc(C(=O)Nc2ccccc2NC(=O)c2ccc(C)o2)o1 to have a lower LogP value.,Cc1ccc(C(=O)Nc2ccccc2NC(=O)c2ccc(C)o2)o1,3.994040000000002
+62425,Please optimize the molecule Cc1ccc(/C=C/C(=O)c2cccc([N+](=O)[O-])c2)cc1C to have a lower LogP value.,Cc1ccc(/C=C/C(=O)c2cccc([N+](=O)[O-])c2)cc1C,4.107740000000002
+149555,Please optimize the molecule O=C(Cn1ccc2ccc(F)cc21)N1CCN(CCc2ccccn2)CC1 to have a lower LogP value.,O=C(Cn1ccc2ccc(F)cc21)N1CCN(CCc2ccccn2)CC1,2.5623000000000005
+164337,Please modify the molecule O=C(NC[C@H]1C[C@@H](O)C[NH+]1Cc1ccccc1)Nc1c(F)cccc1F to increase its LogP value.,O=C(NC[C@H]1C[C@@H](O)C[NH+]1Cc1ccccc1)Nc1c(F)cccc1F,1.3046000000000002
+235654,Modify the molecule c1cc2c(s1)C1(CC[NH2+]CC1)OCC2 to have a lower LogP value.,c1cc2c(s1)C1(CC[NH2+]CC1)OCC2,0.8733000000000001
+2402,Optimize the molecule CC(C)(C)c1ccc(SCC2(CS)CCOCC2)cc1 to have a lower LogP value.,CC(C)(C)c1ccc(SCC2(CS)CCOCC2)cc1,4.802800000000005
+23,Optimize the molecule O=c1n(CCO)c2ccccc2n1CCO to have a higher LogP value.,O=c1n(CCO)c2ccccc2n1CCO,-0.2124000000000003
+24755,Modify the molecule CCc1nn(C)cc1CNC(=O)[C@H]1CCCCN1C(=O)c1cccnc1 to decrease its LogP value.,CCc1nn(C)cc1CNC(=O)[C@H]1CCCCN1C(=O)c1cccnc1,1.6885999999999992
+163726,Please optimize the molecule Cc1ccc(C(C)C)cc1O[C@@H](C)C(=O)N1CCCN(S(C)(=O)=O)CC1 to have a lower LogP value.,Cc1ccc(C(C)C)cc1O[C@@H](C)C(=O)N1CCCN(S(C)(=O)=O)CC1,2.37962
+50301,Modify the molecule C[C@@]1(c2ccc3c(c2)OCCCO3)NC(=O)N(CC(=O)NC2CCCC2)C1=O to have a higher LogP value.,C[C@@]1(c2ccc3c(c2)OCCCO3)NC(=O)N(CC(=O)NC2CCCC2)C1=O,1.673699999999999
+208289,Modify the molecule CS[C@@H]1CC[C@H](NC(=O)N[C@@H](CO)c2ccc(Cl)c(F)c2)C1 to have a lower LogP value.,CS[C@@H]1CC[C@H](NC(=O)N[C@@H](CO)c2ccc(Cl)c(F)c2)C1,3.0958000000000014
+80068,Optimize the molecule CO[C@H](c1ccccc1)N1C(=O)C(C(=O)OC(C)(C)C)=C[C@@H]1C to have a higher LogP value.,CO[C@H](c1ccccc1)N1C(=O)C(C(=O)OC(C)(C)C)=C[C@@H]1C,2.830400000000001
+7083,Optimize the molecule O=C(Nc1ccc(N2CCCC2)c(Cl)c1)C(=O)N1C[C@@H]2CC=CC[C@H]2C1 to have a higher LogP value.,O=C(Nc1ccc(N2CCCC2)c(Cl)c1)C(=O)N1C[C@@H]2CC=CC[C@H]2C1,3.303300000000002
+71010,Optimize the molecule CC(C)c1cccc(C(C)C)c1NC(=O)C(=O)N1CCC2(C1)OCCO2 to have a higher LogP value.,CC(C)c1cccc(C(C)C)c1NC(=O)C(=O)N1CCC2(C1)OCCO2,2.8473000000000006
+216669,Please optimize the molecule N#Cc1ccc(C[NH+]2CCCC[C@H]2Cn2cncn2)c(F)c1 to have a higher LogP value.,N#Cc1ccc(C[NH+]2CCCC[C@H]2Cn2cncn2)c(F)c1,0.9264799999999991
+212913,Optimize the molecule CCCCCC(C)(C)CNC(=O)c1cccc2[nH]ccc12 to have a lower LogP value.,CCCCCC(C)(C)CNC(=O)c1cccc2[nH]ccc12,4.5042000000000035
+99824,Please optimize the molecule CC1=N[C@H](C(=O)N2CCC(CC(=O)NCCC(C)C)CC2)C(C)=C1C to have a lower LogP value.,CC1=N[C@H](C(=O)N2CCC(CC(=O)NCCC(C)C)CC2)C(C)=C1C,2.956900000000001
+204899,Modify the molecule O=C([C@@H]1CCCN1S(=O)(=O)c1ccc(Br)cc1Br)N1CCOCC1 to have a lower LogP value.,O=C([C@@H]1CCCN1S(=O)(=O)c1ccc(Br)cc1Br)N1CCOCC1,2.2234999999999996
+68630,Optimize the molecule NC(=O)N1CCC([NH+]2CCC[C@@H](Oc3ccc(Cl)c(Cl)c3)C2)CC1 to have a higher LogP value.,NC(=O)N1CCC([NH+]2CCC[C@@H](Oc3ccc(Cl)c(Cl)c3)C2)CC1,1.9626
+141302,Modify the molecule Cc1cccc(C)c1NC(=O)COC(=O)C[C@@H]1Sc2ccccc2NC1=O to decrease its LogP value.,Cc1cccc(C)c1NC(=O)COC(=O)C[C@@H]1Sc2ccccc2NC1=O,3.288240000000002
+12864,Modify the molecule CCCOc1ccccc1C[C@H]1C(=O)Nc2ccc(C)cc21 to decrease its LogP value.,CCCOc1ccccc1C[C@H]1C(=O)Nc2ccc(C)cc21,4.0622200000000035
+137028,Modify the molecule CCc1ccc(C(=O)N2CCc3sccc3[C@H]2C)o1 to increase its LogP value.,CCc1ccc(C(=O)N2CCc3sccc3[C@H]2C)o1,3.663000000000003
+228602,Optimize the molecule CCN(C(=O)c1ccc(N2CCCOC2=O)cc1)c1cccc(C)c1 to have a higher LogP value.,CCN(C(=O)c1ccc(N2CCCOC2=O)cc1)c1cccc(C)c1,4.008420000000004
+78763,Modify the molecule COCCCCN1CC[C@H]([NH3+])[C@@H](C)[C@@H]1C to decrease its LogP value.,COCCCCN1CC[C@H]([NH3+])[C@@H](C)[C@@H]1C,0.7538000000000015
+165456,Modify the molecule Cc1noc(CCNC(=O)N[C@H](CO)c2ccc(Cl)cc2)n1 to have a higher LogP value.,Cc1noc(CCNC(=O)N[C@H](CO)c2ccc(Cl)cc2)n1,1.6067199999999997
+197510,Please optimize the molecule C[C@@H]1CCN(C(=O)CCNc2ccccc2[N+](=O)[O-])C[C@@H]1O to have a lower LogP value.,C[C@@H]1CCN(C(=O)CCNc2ccccc2[N+](=O)[O-])C[C@@H]1O,1.6260999999999999
+114744,Optimize the molecule COC(=O)CC[NH+]1CCCC1 to have a lower LogP value.,COC(=O)CC[NH+]1CCCC1,-0.7717999999999992
+229849,Optimize the molecule OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](Cl)[C@@H]1O to have a lower LogP value.,OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](Cl)[C@@H]1O,-1.9749000000000005
+55515,Modify the molecule COc1cc(C)c(C(=O)N(C)c2ccc(Cl)cn2)cc1OC to have a higher LogP value.,COc1cc(C)c(C(=O)N(C)c2ccc(Cl)cn2)cc1OC,3.337220000000002
+248159,Modify the molecule Cc1ccc(N2C[C@H](C(=O)N3CCC(Oc4nc5c(Cl)cccc5s4)CC3)CC2=O)cc1C to have a lower LogP value.,Cc1ccc(N2C[C@H](C(=O)N3CCC(Oc4nc5c(Cl)cccc5s4)CC3)CC2=O)cc1C,4.9894400000000045
+2688,Modify the molecule CC(C)(CNC(=O)c1ccc([N-]S(=O)(=O)c2cc(Cl)sc2Cl)cc1)[NH+]1CCCCC1 to decrease its LogP value.,CC(C)(CNC(=O)c1ccc([N-]S(=O)(=O)c2cc(Cl)sc2Cl)cc1)[NH+]1CCCCC1,4.026200000000003
+91634,Please modify the molecule CSCc1ccc(C(=O)NNC(=O)CSc2ccc(C)cc2)cc1 to decrease its LogP value.,CSCc1ccc(C(=O)NNC(=O)CSc2ccc(C)cc2)cc1,3.4113200000000026
+206599,Modify the molecule [NH3+]C[C@H](c1c[nH]c2ccccc12)C(F)(F)F to decrease its LogP value.,[NH3+]C[C@H](c1c[nH]c2ccccc12)C(F)(F)F,2.0557
+204155,Please modify the molecule C[C@@H]([NH2+]Cc1cccnc1OCC(F)F)c1occc1Br to increase its LogP value.,C[C@@H]([NH2+]Cc1cccnc1OCC(F)F)c1occc1Br,2.9056000000000015
+161062,Modify the molecule Cn1cnc(CNC(=O)c2ccccc2NC(=O)OC(C)(C)C)n1 to increase its LogP value.,Cn1cnc(CNC(=O)c2ccccc2NC(=O)OC(C)(C)C)n1,2.0921
+147366,Modify the molecule O=C1C[C@@H]([C@H]2CCCO2)C(=O)N1Cc1ccccc1 to have a higher LogP value.,O=C1C[C@@H]([C@H]2CCCO2)C(=O)N1Cc1ccccc1,1.7407
+210106,Modify the molecule COc1ccccc1[C@H](NC(=O)c1cc(C)ccc1F)c1ccccn1 to have a higher LogP value.,COc1ccccc1[C@H](NC(=O)c1cc(C)ccc1F)c1ccccn1,4.057120000000002
+208859,Modify the molecule CSc1ccc2cc(CN(C[C@@H]3CCCO3)C(=O)c3ccc(C)s3)c(N3CCCC3)nc2c1 to have a higher LogP value.,CSc1ccc2cc(CN(C[C@@H]3CCCO3)C(=O)c3ccc(C)s3)c(N3CCCC3)nc2c1,5.748220000000006
+50311,Please modify the molecule CC[C@@H](NC(=O)[C@H](c1ccccc1)N(C)CC)C(=O)N1CCOCC1 to decrease its LogP value.,CC[C@@H](NC(=O)[C@H](c1ccccc1)N(C)CC)C(=O)N1CCOCC1,1.433
+91500,Please modify the molecule O=C1S/C(=C/c2ccc3c(c2)OCO3)C(=O)N1CN1CCCC1 to increase its LogP value.,O=C1S/C(=C/c2ccc3c(c2)OCO3)C(=O)N1CN1CCCC1,2.5049
+105043,Modify the molecule [NH3+][C@@H]1CC[C@@H](Nc2cc(C(F)(F)F)ccc2F)C1 to increase its LogP value.,[NH3+][C@@H]1CC[C@@H](Nc2cc(C(F)(F)F)ccc2F)C1,2.4194000000000004
+120752,Optimize the molecule C[C@H]1CCC[NH+](Cc2ccc(CNC(=O)Cc3ccon3)cc2)C1 to have a higher LogP value.,C[C@H]1CCC[NH+](Cc2ccc(CNC(=O)Cc3ccon3)cc2)C1,1.3482999999999996
+224535,Optimize the molecule COc1ccccc1[C@@H](NC(=O)c1ccc2c(c1)CCC2)c1ccccn1 to have a higher LogP value.,COc1ccccc1[C@@H](NC(=O)c1ccc2c(c1)CCC2)c1ccccn1,4.098300000000003
+218283,Modify the molecule CC/[NH+]=C(/NCc1cc(CC)no1)N1CCc2ccccc21 to have a lower LogP value.,CC/[NH+]=C(/NCc1cc(CC)no1)N1CCc2ccccc21,0.8457999999999997
+79471,Modify the molecule N#Cc1c(Cl)nsc1NCc1ccc(C[NH+]2CCCCC2)cc1 to have a higher LogP value.,N#Cc1c(Cl)nsc1NCc1ccc(C[NH+]2CCCCC2)cc1,2.8490800000000007
+27345,Modify the molecule Cc1ccc(Cl)cc1NC(=O)CN(C)S(=O)(=O)c1ccc2[nH]c3c(c2c1)CCCC3 to increase its LogP value.,Cc1ccc(Cl)cc1NC(=O)CN(C)S(=O)(=O)c1ccc2[nH]c3c(c2c1)CCCC3,4.267720000000002
+45780,Modify the molecule C[C@@H](O)[C@@H](NC(=O)CSc1ccncc1)C(=O)[O-] to have a lower LogP value.,C[C@@H](O)[C@@H](NC(=O)CSc1ccncc1)C(=O)[O-],-1.2108000000000003
+44407,Modify the molecule CC[C@@H]1CN(CCSc2ccccc2)[C@H](C2CC2)C[NH2+]1 to have a higher LogP value.,CC[C@@H]1CN(CCSc2ccccc2)[C@H](C2CC2)C[NH2+]1,2.2149
+198727,Modify the molecule COC(=O)C1CCN(c2ncnc(NCc3ccc(OC)cc3)c2N)CC1 to have a higher LogP value.,COC(=O)C1CCN(c2ncnc(NCc3ccc(OC)cc3)c2N)CC1,2.0688999999999993
+139646,Please optimize the molecule NS(=O)(=O)CCNC(=O)c1cc2c(s1)CCCC2 to have a lower LogP value.,NS(=O)(=O)CCNC(=O)c1cc2c(s1)CCCC2,0.6452000000000002
+98059,Modify the molecule CCOCc1ccccc1Cn1c(=O)[nH]c2ccccc2c1=O to have a higher LogP value.,CCOCc1ccccc1Cn1c(=O)[nH]c2ccccc2c1=O,2.2746000000000004
+48764,Modify the molecule O=C(COc1ccccc1Cl)NCCCN1CCOCC1 to decrease its LogP value.,O=C(COc1ccccc1Cl)NCCCN1CCOCC1,1.5572999999999997
+110629,Please modify the molecule CC(=O)O[C@H]1C[C@@H]2[C@@H]3CC[C@H](C(C)=O)[C@@]3(C)C[C@@H](OC(C)=O)[C@H]2[C@@]2(C)CCC(=O)C[C@H]12 to decrease its LogP value.,CC(=O)O[C@H]1C[C@@H]2[C@@H]3CC[C@H](C(C)=O)[C@@]3(C)C[C@@H](OC(C)=O)[C@H]2[C@@]2(C)CCC(=O)C[C@H]12,3.886600000000003
+150725,Please modify the molecule COc1ccc(C(=O)CCC(=O)N(C)[C@H]2CCc3ccccc32)cc1F to decrease its LogP value.,COc1ccc(C(=O)CCC(=O)N(C)[C@H]2CCc3ccccc32)cc1F,3.943100000000003
+24352,Modify the molecule Cc1ccoc1[C@H]([NH3+])[C@@H](C)c1ccncc1 to have a lower LogP value.,Cc1ccoc1[C@H]([NH3+])[C@@H](C)c1ccncc1,2.06972
+241627,Modify the molecule CN(C)C(=O)COc1ccc(NC(=O)c2cn3cccnc3n2)cc1 to decrease its LogP value.,CN(C)C(=O)COc1ccc(NC(=O)c2cn3cccnc3n2)cc1,1.4485999999999997
+9562,Optimize the molecule Cc1cscc1[C@H]([NH3+])c1cc(F)cc(F)c1 to have a lower LogP value.,Cc1cscc1[C@H]([NH3+])c1cc(F)cc(F)c1,2.6660200000000005
+26424,Please modify the molecule C[C@@]1([C@H](O)c2ccccc2F)CCCO1 to decrease its LogP value.,C[C@@]1([C@H](O)c2ccccc2F)CCCO1,2.4282000000000004
+153724,Optimize the molecule C[C@H](NC(=O)C(=O)Nc1ccc2c(c1)OCCO2)c1ccc(F)c(F)c1 to have a lower LogP value.,C[C@H](NC(=O)C(=O)Nc1ccc2c(c1)OCCO2)c1ccc(F)c(F)c1,2.5519000000000007
+99037,Please modify the molecule CN(C(=O)Nc1cccc(-c2nnc3n2CCC3)c1)C1CCCCC1 to increase its LogP value.,CN(C(=O)Nc1cccc(-c2nnc3n2CCC3)c1)C1CCCCC1,3.687700000000002
+13841,Modify the molecule COc1ccc2cc(Br)ccc2c1CC(=O)Nc1nc(C)cs1 to decrease its LogP value.,COc1ccc2cc(Br)ccc2c1CC(=O)Nc1nc(C)cs1,4.557020000000003
+47229,Optimize the molecule CNc1ncc(C(=O)NCCC(=O)NC2CC2)cc1Cl to have a lower LogP value.,CNc1ncc(C(=O)NCCC(=O)NC2CC2)cc1Cl,1.1752
+154521,Please optimize the molecule CC[C@H](O)[C@H]1CCCS(=O)(=O)C1 to have a lower LogP value.,CC[C@H](O)[C@H]1CCCS(=O)(=O)C1,0.5821000000000001
+139596,Modify the molecule COc1ccc(OCCC(CO)CO)cc1 to increase its LogP value.,COc1ccc(OCCC(CO)CO)cc1,1.0649
+156578,Optimize the molecule CCNC(=O)C1(c2ccc(NS(=O)(=O)CC)cc2)CCC1 to have a higher LogP value.,CCNC(=O)C1(c2ccc(NS(=O)(=O)CC)cc2)CCC1,2.0059999999999993
+48989,Modify the molecule CC1=C(c2ccc(C)c(C)c2)S(=O)(=O)N=C1N1CCC(C(=O)NCc2ccco2)CC1 to have a higher LogP value.,CC1=C(c2ccc(C)c(C)c2)S(=O)(=O)N=C1N1CCC(C(=O)NCc2ccco2)CC1,3.3977400000000024
+229798,Optimize the molecule CC[C@@H](CNCc1csc(Br)c1)[NH+]1CCCC1 to have a higher LogP value.,CC[C@@H](CNCc1csc(Br)c1)[NH+]1CCCC1,2.0575
+182751,Modify the molecule O=C(Nc1cccc2ccccc12)N1CCCN2CCC[NH+]=C21 to have a lower LogP value.,O=C(Nc1cccc2ccccc12)N1CCCN2CCC[NH+]=C21,1.2196999999999996
+206566,Please optimize the molecule C/[NH+]=C(/NCc1sc(C)nc1C)N[C@H]1CC[NH+](C2CCCC2)C1 to have a lower LogP value.,C/[NH+]=C(/NCc1sc(C)nc1C)N[C@H]1CC[NH+](C2CCCC2)C1,-0.8946599999999967
+173976,Please modify the molecule O=C(NCc1ccccc1)c1ccccc1NC(=O)[C@@H]1CC(=O)N(c2ccccc2Cl)C1 to decrease its LogP value.,O=C(NCc1ccccc1)c1ccccc1NC(=O)[C@@H]1CC(=O)N(c2ccccc2Cl)C1,4.261600000000003
+200871,Modify the molecule COc1ccccc1NC(=S)N/C(=N\c1nc(C)cc(C)n1)N1CCc2ccccc2C1 to have a lower LogP value.,COc1ccccc1NC(=S)N/C(=N\c1nc(C)cc(C)n1)N1CCc2ccccc2C1,4.134440000000003
+122035,Modify the molecule CN1CCc2ccc(NC(=O)N3CCC[C@H]3CN3CCOCC3)cc2C1=O to have a lower LogP value.,CN1CCc2ccc(NC(=O)N3CCC[C@H]3CN3CCOCC3)cc2C1=O,1.6431999999999998
+202817,Optimize the molecule O=C1[C@H]2[C@H](c3ccccc3)OC3(C(=O)c4ccccc4C3=O)[C@@H]2C(=O)N1c1ccc(Cl)c(Cl)c1 to have a higher LogP value.,O=C1[C@H]2[C@H](c3ccccc3)OC3(C(=O)c4ccccc4C3=O)[C@@H]2C(=O)N1c1ccc(Cl)c(Cl)c1,4.688500000000003
+155046,Modify the molecule CC(C)COC[C@H](C)NC(=O)[C@H]1CCCC[C@@H]1C(=O)N1CCCC1 to decrease its LogP value.,CC(C)COC[C@H](C)NC(=O)[C@H]1CCCC[C@@H]1C(=O)N1CCCC1,2.5925000000000002
+37367,Please modify the molecule CN[C@@H](c1cncnc1)C(C)(C)[NH+]1CCCC1 to decrease its LogP value.,CN[C@@H](c1cncnc1)C(C)(C)[NH+]1CCCC1,0.19440000000000057
+170919,Modify the molecule CC[C@H](CCO)CNc1ncnc(Cl)c1C to have a lower LogP value.,CC[C@H](CCO)CNc1ncnc(Cl)c1C,2.25892
+76323,Modify the molecule COC1CCN(c2cc[nH+]c(C(=O)[O-])c2)CC1 to have a higher LogP value.,COC1CCN(c2cc[nH+]c(C(=O)[O-])c2)CC1,-0.5205999999999997
+162168,Please modify the molecule CCOC(=O)c1nnc2c(-c3ccc(Br)cc3)c(COC)nn2c1N to decrease its LogP value.,CCOC(=O)c1nnc2c(-c3ccc(Br)cc3)c(COC)nn2c1N,2.4590999999999994
+33227,Modify the molecule O=C(Nc1nc2ccccc2[nH]1)C1CCN(C(=O)C2CC2)CC1 to increase its LogP value.,O=C(Nc1nc2ccccc2[nH]1)C1CCN(C(=O)C2CC2)CC1,2.1500000000000004
+200419,Modify the molecule Cc1ccccc1NC(=O)NC[C@@H](c1ccccc1)N1C(=O)c2ccccc2C1=O to decrease its LogP value.,Cc1ccccc1NC(=O)NC[C@@H](c1ccccc1)N1C(=O)c2ccccc2C1=O,4.154020000000003
+60442,Please modify the molecule Cc1nc(-c2cccs2)c(CCC(=O)Nc2ccc(C#N)cc2)s1 to increase its LogP value.,Cc1nc(-c2cccs2)c(CCC(=O)Nc2ccc(C#N)cc2)s1,4.623000000000003
+227025,Please modify the molecule Cc1cc(NC(=O)C(=O)NCC[NH+]2CCN(c3ccccc3)CC2)c2ccccc2n1 to decrease its LogP value.,Cc1cc(NC(=O)C(=O)NCC[NH+]2CCN(c3ccccc3)CC2)c2ccccc2n1,1.0030200000000018
+95104,Optimize the molecule O=C(Cc1ccon1)N1CCCN(Cc2ccccc2)c2ccccc21 to have a lower LogP value.,O=C(Cc1ccon1)N1CCCN(Cc2ccccc2)c2ccccc21,3.6606000000000023
+53136,Modify the molecule CC(C)(C)S(=O)(=O)CC(=O)NCc1ccc(-c2ccccc2C#N)cc1 to have a lower LogP value.,CC(C)(C)S(=O)(=O)CC(=O)NCc1ccc(-c2ccccc2C#N)cc1,3.054780000000002
+35102,Optimize the molecule COc1c(F)cc(F)c(C(=O)[O-])c1F to have a lower LogP value.,COc1c(F)cc(F)c(C(=O)[O-])c1F,0.4760000000000001
+141980,Modify the molecule Cc1nccn1C(=O)c1nn(C)c2c1COc1ccccc1-2 to decrease its LogP value.,Cc1nccn1C(=O)c1nn(C)c2c1COc1ccccc1-2,2.1729199999999995
+8994,Please optimize the molecule O=C(N[C@H]1CCCC[NH2+]C1)c1n[nH]c(C2CC2)n1 to have a lower LogP value.,O=C(N[C@H]1CCCC[NH2+]C1)c1n[nH]c(C2CC2)n1,-0.47219999999999906
+212195,Optimize the molecule CCCS(=O)(=O)N1CCC[C@@H](C(=O)NCc2ccc(N(C)C)cc2)C1 to have a lower LogP value.,CCCS(=O)(=O)N1CCC[C@@H](C(=O)NCc2ccc(N(C)C)cc2)C1,1.8205999999999996
+105947,Modify the molecule Cc1ccc(Cl)cc1N1CCN(CC(=O)c2ccc3c(c2)OCO3)CC1 to have a lower LogP value.,Cc1ccc(Cl)cc1N1CCN(CC(=O)c2ccc3c(c2)OCO3)CC1,3.3820200000000016
+245610,Modify the molecule C[C@@H]1CCCCN1C(=O)CN1CCN([C@@H](C(=O)N2CCCCC2)c2ccccc2)CC1 to have a higher LogP value.,C[C@@H]1CCCCN1C(=O)CN1CCN([C@@H](C(=O)N2CCCCC2)c2ccccc2)CC1,2.758800000000001
+206418,Modify the molecule C[C@@H]1CN(C(=O)c2ccc(=O)[nH]c2)C[C@H](c2ccccc2)O1 to have a higher LogP value.,C[C@@H]1CN(C(=O)c2ccc(=O)[nH]c2)C[C@H](c2ccccc2)O1,1.9771000000000003
+108044,Modify the molecule Cn1cc(C(=O)N2CCN(CCO)[C@@H]3CS(=O)(=O)C[C@@H]32)c2ccccc21 to have a lower LogP value.,Cn1cc(C(=O)N2CCN(CCO)[C@@H]3CS(=O)(=O)C[C@@H]32)c2ccccc21,0.09400000000000164
+82825,Optimize the molecule CC(C)COC(=O)c1ccc(NC(=O)[C@H]2[C@@H](C(=O)[O-])[C@@H]3C=C[C@H]2C3)cc1 to have a higher LogP value.,CC(C)COC(=O)c1ccc(NC(=O)[C@H]2[C@@H](C(=O)[O-])[C@@H]3C=C[C@H]2C3)cc1,1.6260999999999994
+246837,Modify the molecule Fc1cnccc1-c1nc([C@@H]2CCOC2)no1 to decrease its LogP value.,Fc1cnccc1-c1nc([C@@H]2CCOC2)no1,1.7745999999999997
+113606,Optimize the molecule CCCCc1noc(C[C@@H](C)O)n1 to have a higher LogP value.,CCCCc1noc(C[C@@H](C)O)n1,1.3355
+149837,Modify the molecule COCCS[C@@H]1C[C@H](C)CC[C@H]1C#N to have a lower LogP value.,COCCS[C@@H]1C[C@H](C)CC[C@H]1C#N,2.6943800000000007
+5151,Modify the molecule COc1ccccc1-n1nnnc1S[C@@H](C)C(=O)Nc1cccc(Cl)c1C to increase its LogP value.,COc1ccccc1-n1nnnc1S[C@@H](C)C(=O)Nc1cccc(Cl)c1C,3.7520200000000026
+210236,Modify the molecule C[C@@H]1C[C@@H]1COC(=O)[C@@H](C)N1CCc2ccccc2C1 to have a lower LogP value.,C[C@@H]1C[C@@H]1COC(=O)[C@@H](C)N1CCc2ccccc2C1,2.6324000000000014
+113570,Please modify the molecule N#Cc1cnc(S[C@@H](C(=O)Nc2ccccc2)c2ccccc2)nc1N to increase its LogP value.,N#Cc1cnc(S[C@@H](C(=O)Nc2ccccc2)c2ccccc2)nc1N,3.4025800000000004
+173894,Please modify the molecule CCN(Cc1cccc(C)n1)C(=O)[C@H]([NH3+])CC(N)=O to increase its LogP value.,CCN(Cc1cccc(C)n1)C(=O)[C@H]([NH3+])CC(N)=O,-0.7755799999999975
+214504,Optimize the molecule C[C@H]1CCCC[C@@H]1NC(=O)Nc1ccccc1C(=O)NC(C)(C)C to have a higher LogP value.,C[C@H]1CCCC[C@@H]1NC(=O)Nc1ccccc1C(=O)NC(C)(C)C,3.9151000000000025
+96364,Optimize the molecule Cc1cccc(NC(=O)C(=O)NCC2CC[NH+](Cc3cccs3)CC2)c1 to have a higher LogP value.,Cc1cccc(NC(=O)C(=O)NCC2CC[NH+](Cc3cccs3)CC2)c1,1.6063200000000002
+112116,Modify the molecule COc1ccc(Cl)cc1NC(=O)C(=O)NC[C@H](c1ccc2c(c1)CCN2C)[NH+]1CCCC1 to decrease its LogP value.,COc1ccc(Cl)cc1NC(=O)C(=O)NC[C@H](c1ccc2c(c1)CCN2C)[NH+]1CCCC1,1.8155999999999994
+68919,Modify the molecule CC(=O)Oc1ccc(C(=O)Nc2ccc(-c3nc4ccccc4[nH]3)cc2)cc1 to have a higher LogP value.,CC(=O)Oc1ccc(C(=O)Nc2ccc(-c3nc4ccccc4[nH]3)cc2)cc1,4.407500000000002
+90399,Please optimize the molecule CC(=O)N[C@H](/C([O-])=N/S(=O)(=O)c1ccc(C)cc1)C1CCCC1 to have a lower LogP value.,CC(=O)N[C@H](/C([O-])=N/S(=O)(=O)c1ccc(C)cc1)C1CCCC1,1.13742
+210222,Modify the molecule COC(=O)C1=C(CN2CCN(c3ccc(F)cc3)CC2)NC(=O)N[C@@H]1c1cccc(Cl)c1 to increase its LogP value.,COC(=O)C1=C(CN2CCN(c3ccc(F)cc3)CC2)NC(=O)N[C@@H]1c1cccc(Cl)c1,3.0823
+165362,Please optimize the molecule Cc1nc(C)n([C@H]2CCCN(C(=O)[C@@H]3CCS(=O)(=O)C3)C2)n1 to have a higher LogP value.,Cc1nc(C)n([C@H]2CCCN(C(=O)[C@@H]3CCS(=O)(=O)C3)C2)n1,0.49314000000000013
+194715,Modify the molecule CC(=O)Nc1ccc(Cl)c(NS(=O)(=O)c2ccc(CN3C(=O)c4ccccc4C3=O)cc2)c1 to have a higher LogP value.,CC(=O)Nc1ccc(Cl)c(NS(=O)(=O)c2ccc(CN3C(=O)c4ccccc4C3=O)cc2)c1,3.895400000000002
+215417,Modify the molecule COC[C@H](O)CNc1nc2ccc(N)cc2o1 to have a lower LogP value.,COC[C@H](O)CNc1nc2ccc(N)cc2o1,0.8291999999999999
+7360,Please optimize the molecule C[NH+](C)[C@@H]1CC[C@H](NC(=O)CCC(=O)c2ccc3c(c2)CCC3)C1 to have a lower LogP value.,C[NH+](C)[C@@H]1CC[C@H](NC(=O)CCC(=O)c2ccc3c(c2)CCC3)C1,1.3200000000000003
+47167,Modify the molecule C[C@H](NC(=O)c1ccco1)c1nc2ccccc2n1[C@H](C)c1ccccc1 to decrease its LogP value.,C[C@H](NC(=O)c1ccco1)c1nc2ccccc2n1[C@H](C)c1ccccc1,4.729600000000004
+209637,Please modify the molecule CCONC(=O)c1cnc2sc(C)cn2c1=O to decrease its LogP value.,CCONC(=O)c1cnc2sc(C)cn2c1=O,0.7457199999999999
+73300,Modify the molecule CCN(CCC#N)C(=O)Nc1ccc(OCc2ccccn2)c(F)c1 to have a higher LogP value.,CCN(CCC#N)C(=O)Nc1ccc(OCc2ccccn2)c(F)c1,3.5671800000000022
+66172,Modify the molecule C[C@H]1OCC[C@@H]1C(=O)N1C[C@H](CC[NH3+])c2ccccc21 to have a higher LogP value.,C[C@H]1OCC[C@@H]1C(=O)N1C[C@H](CC[NH3+])c2ccccc21,1.173800000000001
+199507,Please optimize the molecule CCO[C@@H](C)c1noc(CS[C@@H](C)c2ccc3ccccc3c2)n1 to have a lower LogP value.,CCO[C@@H](C)c1noc(CS[C@@H](C)c2ccc3ccccc3c2)n1,5.3147000000000055
+1350,Modify the molecule CC1=[N+](c2ccc(C)cc2)C(SCC(=O)Nc2cccc(C(F)(F)F)c2)=NC(C)(C)C1 to have a lower LogP value.,CC1=[N+](c2ccc(C)cc2)C(SCC(=O)Nc2cccc(C(F)(F)F)c2)=NC(C)(C)C1,6.028920000000005
+166551,Modify the molecule CCCSCc1cc(F)cc(Br)c1 to have a higher LogP value.,CCCSCc1cc(F)cc(Br)c1,4.2314000000000025
+49946,Please optimize the molecule Cc1cccc(S(=O)(=O)[C@H](C)C(=O)Nc2cc(F)ccc2F)c1 to have a lower LogP value.,Cc1cccc(S(=O)(=O)[C@H](C)C(=O)Nc2cc(F)ccc2F)c1,3.0741200000000015
+169794,Optimize the molecule O=C(NCCNC(=O)C1CC1)N[C@@H]1CCO[C@@H]1c1ccc(Cl)cc1 to have a lower LogP value.,O=C(NCCNC(=O)C1CC1)N[C@@H]1CCO[C@@H]1c1ccc(Cl)cc1,1.9954000000000003
+84897,Optimize the molecule Cc1ccc(CC(=O)N2CCC(c3c[nH]c4ncccc34)CC2)cn1 to have a higher LogP value.,Cc1ccc(CC(=O)N2CCC(c3c[nH]c4ncccc34)CC2)cn1,3.2150200000000018
+93337,Please modify the molecule CCOC(=O)NNC(=O)c1ccc(C[NH+](C)C)cc1 to increase its LogP value.,CCOC(=O)NNC(=O)c1ccc(C[NH+](C)C)cc1,-0.2779999999999987
+20336,Optimize the molecule O=C(N/N=C/c1cccc(Cl)c1)c1ccc(CN2CCc3ccccc3C2)cc1 to have a higher LogP value.,O=C(N/N=C/c1cccc(Cl)c1)c1ccc(CN2CCc3ccccc3C2)cc1,4.662200000000004
+123641,Modify the molecule CN(C)c1nc(Cl)nc(NCCC(=O)NC2CC2)n1 to have a lower LogP value.,CN(C)c1nc(Cl)nc(NCCC(=O)NC2CC2)n1,0.6715999999999995
+53740,Optimize the molecule O=C(NCc1ccncc1)[C@H]1CCCC[NH2+]1 to have a lower LogP value.,O=C(NCc1ccncc1)[C@H]1CCCC[NH2+]1,-0.18630000000000002
+17290,Modify the molecule COc1ccc([C@@H](C(=O)[O-])[C@H](C(=O)[O-])c2ccccc2)cc1 to have a higher LogP value.,COc1ccc([C@@H](C(=O)[O-])[C@H](C(=O)[O-])c2ccccc2)cc1,0.06240000000000001
+124642,Modify the molecule CCCN(CC#N)Cc1cn(C)nc1-c1ccc2c(c1)OCCCO2 to increase its LogP value.,CCCN(CC#N)Cc1cn(C)nc1-c1ccc2c(c1)OCCCO2,2.9839800000000016
+245220,Optimize the molecule O[C@@H]1C=C([C@H]2CCc3cccnc32)CCC1 to have a higher LogP value.,O[C@@H]1C=C([C@H]2CCc3cccnc32)CCC1,2.582600000000001
+58439,Modify the molecule O=[N+]([O-])c1cc2c(c(CSc3nc(-c4ccccc4)n[nH]3)c1)OCOC2 to decrease its LogP value.,O=[N+]([O-])c1cc2c(c(CSc3nc(-c4ccccc4)n[nH]3)c1)OCOC2,3.538700000000002
+85585,Optimize the molecule CC(C)Cc1noc(CN2C[C@@H](C)N(C(=O)OC(C)(C)C)C[C@H]2C)n1 to have a higher LogP value.,CC(C)Cc1noc(CN2C[C@@H](C)N(C(=O)OC(C)(C)C)C[C@H]2C)n1,3.097800000000002
+47284,Please optimize the molecule C[C@H]1CCC[C@@]([C@H](O)CCCS(C)(=O)=O)([NH+](C)C)C1 to have a higher LogP value.,C[C@H]1CCC[C@@]([C@H](O)CCCS(C)(=O)=O)([NH+](C)C)C1,0.26550000000000185
+136621,Modify the molecule Cc1ccc(Oc2ccc(NC(=O)[C@@H]3CCS(=O)(=O)C3)cn2)cc1 to increase its LogP value.,Cc1ccc(Oc2ccc(NC(=O)[C@@H]3CCS(=O)(=O)C3)cn2)cc1,2.5555200000000005
+161801,Please optimize the molecule Cc1cc(N2CCOCC2)ccc1NC(=O)C(=O)N[C@H]1CCC[C@H](C)[C@@H]1C to have a higher LogP value.,Cc1cc(N2CCOCC2)ccc1NC(=O)C(=O)N[C@H]1CCC[C@H](C)[C@@H]1C,2.7110200000000004
+93575,Please optimize the molecule Cc1ccc2nc(CC(=O)c3ccoc3C)[nH]c(=O)c2c1 to have a higher LogP value.,Cc1ccc2nc(CC(=O)c3ccoc3C)[nH]c(=O)c2c1,2.5583400000000003
+89874,Modify the molecule C/[NH+]=C(/NCc1sc(C)nc1C)N[C@H](C)c1ccccc1 to decrease its LogP value.,C/[NH+]=C(/NCc1sc(C)nc1C)N[C@H](C)c1ccccc1,1.26674
+40559,Optimize the molecule C[C@H]1CC[C@@H](C)C[NH+]1CC(=O)N1CCO[C@H]2CCCC[C@@H]21 to have a lower LogP value.,C[C@H]1CC[C@@H](C)C[NH+]1CC(=O)N1CCO[C@H]2CCCC[C@@H]21,0.8597000000000006
+144936,Please optimize the molecule C[C@@H](Cc1nnc(NC(=O)Cc2ccc(F)cc2)s1)c1ccccc1 to have a higher LogP value.,C[C@@H](Cc1nnc(NC(=O)Cc2ccc(F)cc2)s1)c1ccccc1,4.204600000000003
+185016,Modify the molecule Cn1ncnc1CCNC(=O)Nc1ccc(F)cc1-c1ccc(F)cc1 to increase its LogP value.,Cn1ncnc1CCNC(=O)Nc1ccc(F)cc1-c1ccc(F)cc1,3.124500000000001
+21552,Optimize the molecule CC1(C)CC(=O)C2=C(C1)Nc1[nH]c(=O)[nH]c(=O)c1[C@@H]2c1ccc(Br)s1 to have a higher LogP value.,CC1(C)CC(=O)C2=C(C1)Nc1[nH]c(=O)[nH]c(=O)c1[C@@H]2c1ccc(Br)s1,3.0878000000000005
+244487,Modify the molecule CCN(CCO)C(=O)C[C@@H]1C(=O)NCCN1Cc1c(F)cccc1Cl to have a lower LogP value.,CCN(CCO)C(=O)C[C@@H]1C(=O)NCCN1Cc1c(F)cccc1Cl,1.0104000000000002
+147748,Modify the molecule CC(C)c1cc(C(=O)N2CCSCC2)on1 to increase its LogP value.,CC(C)c1cc(C(=O)N2CCSCC2)on1,1.987
+58806,Please modify the molecule N#Cc1ccc(NC(=O)CCCC(=O)N2CCN(c3ccc(F)cc3)CC2)cc1 to increase its LogP value.,N#Cc1ccc(NC(=O)CCCC(=O)N2CCN(c3ccc(F)cc3)CC2)cc1,3.154980000000002
+232477,Please optimize the molecule COC(C)(C)CNC(=O)NC[C@H](O)c1ccc2ccccc2c1 to have a lower LogP value.,COC(C)(C)CNC(=O)NC[C@H](O)c1ccc2ccccc2c1,2.5974000000000004
+193867,Optimize the molecule CCN[C@@H](Cc1ccc(O)cc1)[C@@](C)(CC)[NH+]1CCCC1 to have a higher LogP value.,CCN[C@@H](Cc1ccc(O)cc1)[C@@](C)(CC)[NH+]1CCCC1,1.7601999999999998
+6497,Modify the molecule CCCC1=C(C(=O)OCC)[C@H](c2ccc([N+](=O)[O-])cc2)NC(=O)N1C to decrease its LogP value.,CCCC1=C(C(=O)OCC)[C@H](c2ccc([N+](=O)[O-])cc2)NC(=O)N1C,2.908200000000001
+90162,Please optimize the molecule C[C@@H]([NH3+])CCNC(=O)c1ccncc1Cl to have a higher LogP value.,C[C@@H]([NH3+])CCNC(=O)c1ccncc1Cl,0.4853000000000001
+242192,Modify the molecule CCCS(=O)(=O)N1CCC[C@H](C(=O)N2CCC([NH+](C)C)CC2)C1 to have a lower LogP value.,CCCS(=O)(=O)N1CCC[C@H](C(=O)N2CCC([NH+](C)C)CC2)C1,-0.4262999999999959
+111317,Please optimize the molecule CC1(C)C(=O)N([C@H]2COC[C@@H]2C(=O)[O-])S1(=O)=O to have a higher LogP value.,CC1(C)C(=O)N([C@H]2COC[C@@H]2C(=O)[O-])S1(=O)=O,-2.298099999999998
+176099,Modify the molecule O=C(CCC(=O)c1ccc2c(c1)CCC2)Nc1ccc2c(c1)OC1(CCCC1)O2 to decrease its LogP value.,O=C(CCC(=O)c1ccc2c(c1)CCC2)Nc1ccc2c(c1)OC1(CCCC1)O2,4.818400000000004
+97776,Modify the molecule CC(=O)C[C@@H]1CCC[NH+]1Cc1cccnc1 to increase its LogP value.,CC(=O)C[C@@H]1CCC[NH+]1Cc1cccnc1,0.6079999999999997
+10036,Please modify the molecule O=C([O-])c1cc(-c2ccc(F)c(C(F)(F)F)c2)cnc1O to increase its LogP value.,O=C([O-])c1cc(-c2ccc(F)c(C(F)(F)F)c2)cnc1O,1.9755999999999996
+167885,Please optimize the molecule CC(C)C[NH2+]Cc1ccc(Br)cc1-n1ccnc1C#N to have a lower LogP value.,CC(C)C[NH2+]Cc1ccc(Br)cc1-n1ccnc1C#N,2.22588
+90988,Please modify the molecule N[C@@H](c1ccc([S-])cc1O)C(F)(F)F to increase its LogP value.,N[C@@H](c1ccc([S-])cc1O)C(F)(F)F,1.8601000000000005
+107577,Optimize the molecule CS(=O)(=O)CCN1CCN(c2[nH]c3ccccc3[nH+]2)CC1 to have a higher LogP value.,CS(=O)(=O)CCN1CCN(c2[nH]c3ccccc3[nH+]2)CC1,0.14860000000000145
+239264,Modify the molecule COc1cc2c3nc4n(c(=O)c3n(CC(=O)NC(C)C)c2cc1OC)CCS4 to increase its LogP value.,COc1cc2c3nc4n(c(=O)c3n(CC(=O)NC(C)C)c2cc1OC)CCS4,1.9986999999999995
+77853,Please optimize the molecule NC(=O)c1n[nH]c2ccc(NC(=O)C3CCN(c4cnccn4)CC3)cc12 to have a lower LogP value.,NC(=O)c1n[nH]c2ccc(NC(=O)C3CCN(c4cnccn4)CC3)cc12,1.3068999999999986
+219352,Please modify the molecule C[C@@H](NC(=O)CS(=O)(=O)c1nncn1C)c1ccc(Br)cc1 to decrease its LogP value.,C[C@@H](NC(=O)CS(=O)(=O)c1nncn1C)c1ccc(Br)cc1,1.2287000000000006
+80947,Please modify the molecule [NH3+]C1(C(=O)N2[C@H]3CCCC[C@H]3CC[C@@H]2C(=O)[O-])CC1 to increase its LogP value.,[NH3+]C1(C(=O)N2[C@H]3CCCC[C@H]3CC[C@@H]2C(=O)[O-])CC1,-0.9393999999999985
+45719,Please optimize the molecule COc1ccc(CCC(=O)NCc2ccccc2Cl)cc1OC to have a higher LogP value.,COc1ccc(CCC(=O)NCc2ccccc2Cl)cc1OC,3.606200000000002
+24534,Modify the molecule Cc1ccc(NC(=O)[C@H]2CCC[NH+](Cc3cccc4cn[nH]c34)C2)nc1 to have a higher LogP value.,Cc1ccc(NC(=O)[C@H]2CCC[NH+](Cc3cccc4cn[nH]c34)C2)nc1,1.6999199999999992
+79931,Optimize the molecule CCn1cc(C[NH+]2CCC(C(=O)NCc3ccccc3)CC2)c2cc(OC)ccc21 to have a higher LogP value.,CCn1cc(C[NH+]2CCC(C(=O)NCc3ccccc3)CC2)c2cc(OC)ccc21,2.7811000000000012
+183918,Optimize the molecule O=C(NCC1(c2ccc(Cl)cc2)CC1)NOCc1ccccc1 to have a higher LogP value.,O=C(NCC1(c2ccc(Cl)cc2)CC1)NOCc1ccccc1,3.8026000000000026
+220326,Please optimize the molecule Cc1cccc(O[C@H](C)C(=O)N/N=C/c2ccco2)c1 to have a lower LogP value.,Cc1cccc(O[C@H](C)C(=O)N/N=C/c2ccco2)c1,2.5056200000000004
+90536,Please modify the molecule COc1ccc2cc(C(=O)N[C@H]3C[C@H]3C)c(C)nc2c1 to decrease its LogP value.,COc1ccc2cc(C(=O)N[C@H]3C[C@H]3C)c(C)nc2c1,2.6900200000000005
+143166,Modify the molecule O=C(NNc1ccccc1)[C@H]1CCCN(S(=O)(=O)c2cccs2)C1 to have a lower LogP value.,O=C(NNc1ccccc1)[C@H]1CCCN(S(=O)(=O)c2cccs2)C1,2.2921000000000005
+61730,Please modify the molecule O=C([O-])[C@H]1Cc2[nH]c[nH+]c2CN1C(=O)CC12CC3CC(CC(C3)C1)C2 to increase its LogP value.,O=C([O-])[C@H]1Cc2[nH]c[nH+]c2CN1C(=O)CC12CC3CC(CC(C3)C1)C2,0.43849999999999967
+18982,Optimize the molecule CSc1ccc(C(=O)CN2C(=O)c3ccccc3C2=O)cc1NC(C)=O to have a lower LogP value.,CSc1ccc(C(=O)CN2C(=O)c3ccccc3C2=O)cc1NC(C)=O,2.8458000000000006
+11064,Modify the molecule Cc1ccc(F)cc1NC(=O)CSc1nnc(-c2cccnc2)o1 to have a lower LogP value.,Cc1ccc(F)cc1NC(=O)CSc1nnc(-c2cccnc2)o1,3.309920000000001
+147987,Optimize the molecule CC(=O)c1ccccc1-c1ccc(C(=O)NC[C@H]2CC[NH+](CC(C)C)C2)cn1 to have a higher LogP value.,CC(=O)c1ccccc1-c1ccc(C(=O)NC[C@H]2CC[NH+](CC(C)C)C2)cn1,2.2417999999999996
+106150,Optimize the molecule CCCNC(=O)CN(C)C(=O)CN1CC[C@H]([NH3+])[C@H](C)C1 to have a higher LogP value.,CCCNC(=O)CN(C)C(=O)CN1CC[C@H]([NH3+])[C@H](C)C1,-1.0766999999999967
+114461,Modify the molecule CN(C(=O)CN1CC[NH2+]CC1)C1CCC(C)(C)CC1 to decrease its LogP value.,CN(C(=O)CN1CC[NH2+]CC1)C1CCC(C)(C)CC1,0.2926000000000013
+41838,Please optimize the molecule COc1ccc(Br)c(C=O)c1NC(C)=O to have a lower LogP value.,COc1ccc(Br)c(C=O)c1NC(C)=O,2.2286
+58943,Modify the molecule CN(Cc1ccccc1)C(=O)CSc1nnc(-c2ccncc2)n1-c1ccc(Cl)cc1 to have a higher LogP value.,CN(Cc1ccccc1)C(=O)CSc1nnc(-c2ccncc2)n1-c1ccc(Cl)cc1,4.733400000000004
+83725,Please modify the molecule Cc1cc(I)ccc1NC(=O)CCC(=O)N/N=C/c1ccc(N(C)C)cc1 to decrease its LogP value.,Cc1cc(I)ccc1NC(=O)CCC(=O)N/N=C/c1ccc(N(C)C)cc1,3.534620000000002
+132507,Optimize the molecule COc1ccc(NC(=O)c2ccc(COc3ccccc3Cl)o2)cc1OC to have a lower LogP value.,COc1ccc(NC(=O)c2ccc(COc3ccccc3Cl)o2)cc1OC,4.781500000000004
+137895,Modify the molecule Cc1nn(C)c2nc(C3CC3)cc(C(=O)N(c3ccccc3)C(C)C)c12 to have a lower LogP value.,Cc1nn(C)c2nc(C3CC3)cc(C(=O)N(c3ccccc3)C(C)C)c12,4.2093200000000035
+96489,Please modify the molecule O=C(CCSc1nc2ccccc2[nH]1)N1CCOCC1 to increase its LogP value.,O=C(CCSc1nc2ccccc2[nH]1)N1CCOCC1,1.9039000000000001
+154599,Please optimize the molecule CCC(=O)Nc1ccc(C)c(NC(=O)NCC2(N3CCOCC3)CCCCC2)c1 to have a lower LogP value.,CCC(=O)Nc1ccc(C)c(NC(=O)NCC2(N3CCOCC3)CCCCC2)c1,3.5001200000000017
+4047,Please modify the molecule O=C(Cc1cc2ccccc2[nH]1)N/N=C/c1c[nH]c2ccccc12 to increase its LogP value.,O=C(Cc1cc2ccccc2[nH]1)N/N=C/c1c[nH]c2ccccc12,3.3420000000000014
+202889,Modify the molecule C[C@@]1(C2CCN(C(=O)/C=C/c3cc(F)cc(F)c3)CC2)NC(=O)N(Cc2ccncc2)C1=O to increase its LogP value.,C[C@@]1(C2CCN(C(=O)/C=C/c3cc(F)cc(F)c3)CC2)NC(=O)N(Cc2ccncc2)C1=O,3.122300000000002
+142500,Modify the molecule C[C@H](c1ccc(NCc2cn(C)nc2C(C)(C)C)cc1)N1CCOCC1 to decrease its LogP value.,C[C@H](c1ccc(NCc2cn(C)nc2C(C)(C)C)cc1)N1CCOCC1,3.7229000000000028
+100184,Please modify the molecule CO[C@]1(C)C[C@@H](N(C)C(=O)NCC(=O)N(C)C)C1(C)C to decrease its LogP value.,CO[C@]1(C)C[C@@H](N(C)C(=O)NCC(=O)N(C)C)C1(C)C,0.9196000000000004
+57663,Modify the molecule Cc1cc(-n2cnnc2)cc(C)c1NC(=O)c1ccccc1 to decrease its LogP value.,Cc1cc(-n2cnnc2)cc(C)c1NC(=O)c1ccccc1,3.1364400000000012
+164686,Optimize the molecule Clc1ccc(OCc2nn3c(-c4cccnc4)nnc3s2)cc1 to have a higher LogP value.,Clc1ccc(OCc2nn3c(-c4cccnc4)nnc3s2)cc1,3.4802000000000017
+225958,Modify the molecule Oc1c(F)ccc2cc[nH]c12 to decrease its LogP value.,Oc1c(F)ccc2cc[nH]c12,2.0125999999999995
+153935,Optimize the molecule CCn1ccnc(N(C)CC(=O)NC2CC2)c1=O to have a lower LogP value.,CCn1ccnc(N(C)CC(=O)NC2CC2)c1=O,-0.02200000000000002
+117419,Optimize the molecule O=S1(=O)CCC([NH2+][C@H]2CCC[C@H]2[C@@H]2CCC[NH2+]2)CC1 to have a higher LogP value.,O=S1(=O)CCC([NH2+][C@H]2CCC[C@H]2[C@@H]2CCC[NH2+]2)CC1,-0.9784999999999962
+168333,Modify the molecule CC(C)([C@@H](O)[C@@H]1CCOC2(CCC2)C1)N1CCOCC1 to have a lower LogP value.,CC(C)([C@@H](O)[C@@H]1CCOC2(CCC2)C1)N1CCOCC1,1.8074
+134358,Please modify the molecule O=C(CSc1cccc2cccnc12)Nc1ccc(Br)cc1 to increase its LogP value.,O=C(CSc1cccc2cccnc12)Nc1ccc(Br)cc1,4.728100000000002
+213289,Modify the molecule Cc1nn(CC(=O)Nc2ccc(S(=O)(=O)[N-]c3nccs3)cc2)c(C)c1Cl to have a lower LogP value.,Cc1nn(CC(=O)Nc2ccc(S(=O)(=O)[N-]c3nccs3)cc2)c(C)c1Cl,3.642640000000002
+200493,Modify the molecule CC[NH+]1CCCC[C@@H]1CNC(=O)C[C@@H](C)NC(=O)C1CCCC1 to increase its LogP value.,CC[NH+]1CCCC[C@@H]1CNC(=O)C[C@@H](C)NC(=O)C1CCCC1,0.6449000000000018
+70887,Optimize the molecule Cc1c(CC(=O)N(C)C2CCCCC2)c2c(n1C[C@H]1CCCO1)CCCC2=O to have a higher LogP value.,Cc1c(CC(=O)N(C)C2CCCCC2)c2c(n1C[C@H]1CCCO1)CCCC2=O,3.828120000000003
+142591,Optimize the molecule C#CCNCC(=O)N1CCN(CC(F)(F)F)CC1 to have a higher LogP value.,C#CCNCC(=O)N1CCN(CC(F)(F)F)CC1,-0.08430000000000026
+194363,Please modify the molecule CC(C)[NH+](C)CCNC(=O)C[C@H](O)c1ccccc1 to decrease its LogP value.,CC(C)[NH+](C)CCNC(=O)C[C@H](O)c1ccccc1,0.14940000000000114
+26491,Optimize the molecule N#Cc1cccc(-c2ccnc(C(=O)[O-])c2)c1F to have a higher LogP value.,N#Cc1cccc(-c2ccnc(C(=O)[O-])c2)c1F,1.1228799999999999
+176139,Please modify the molecule C[C@@H](CC(=O)Nc1cccc(OCC#N)c1)CC(C)(C)C to increase its LogP value.,C[C@@H](CC(=O)Nc1cccc(OCC#N)c1)CC(C)(C)C,3.989880000000003
+113733,Optimize the molecule C=CCOc1c(CNc2ccc(N3CCCC3)cc2C)c(C)nn1C to have a lower LogP value.,C=CCOc1c(CNc2ccc(N3CCCC3)cc2C)c(C)nn1C,3.814040000000003
+136561,Modify the molecule Cc1c2c(cc3c1O/C(=C\c1ccccc1Br)C3=O)CN(Cc1cccnc1)CO2 to increase its LogP value.,Cc1c2c(cc3c1O/C(=C\c1ccccc1Br)C3=O)CN(Cc1cccnc1)CO2,5.120820000000005
+113348,Please modify the molecule N#C[C@H]1COCCN1Cc1ccc(F)cc1F to decrease its LogP value.,N#C[C@H]1COCCN1Cc1ccc(F)cc1F,1.6891800000000001
+46973,Modify the molecule O=C(NCCc1ccccn1)[C@@H](Sc1ccccc1)c1ccccc1 to have a higher LogP value.,O=C(NCCc1ccccn1)[C@@H](Sc1ccccc1)c1ccccc1,4.273900000000003
+39486,Please modify the molecule Cc1cc(C)c(-c2csc(NC(=O)CC3=c4ccccc4=[NH+]C3)n2)c(C)c1 to increase its LogP value.,Cc1cc(C)c(-c2csc(NC(=O)CC3=c4ccccc4=[NH+]C3)n2)c(C)c1,1.6286599999999993
+53193,Optimize the molecule COc1cccc(COc2cc(C(C)C)nc(C(C)C)n2)c1 to have a lower LogP value.,COc1cccc(COc2cc(C(C)C)nc(C(C)C)n2)c1,4.3110000000000035
+103454,Modify the molecule C[C@H](Oc1ccc(Oc2ccccc2)cc1)C(=O)Nc1ccncc1 to decrease its LogP value.,C[C@H](Oc1ccc(Oc2ccccc2)cc1)C(=O)Nc1ccncc1,4.279900000000002
+41944,Modify the molecule COc1ccc(OCC(=O)Nc2cccc3nsnc23)cc1 to have a lower LogP value.,COc1ccc(OCC(=O)Nc2cccc3nsnc23)cc1,2.7174000000000005
+64517,Modify the molecule O=C(COc1ccc(F)c(Cl)c1)NCCC[C@H]1CCCC[C@H]1O to increase its LogP value.,O=C(COc1ccc(F)c(Cl)c1)NCCC[C@H]1CCCC[C@H]1O,3.305400000000002
+3619,Please optimize the molecule CC1(C)CN(c2nc(C(F)F)nc3ccccc23)CC[S@@]1=O to have a higher LogP value.,CC1(C)CN(c2nc(C(F)F)nc3ccccc23)CC[S@@]1=O,2.9147000000000007
+191081,Please modify the molecule CCS(=O)(=O)NCCNC(=O)N1CCC[C@@H](c2[nH]cc[nH+]2)C1 to increase its LogP value.,CCS(=O)(=O)NCCNC(=O)N1CCC[C@@H](c2[nH]cc[nH+]2)C1,-0.342899999999998
+149326,Modify the molecule Cc1oc(-c2ccsc2)nc1CC(=O)NCCCc1nnc2n1CCCCC2 to have a lower LogP value.,Cc1oc(-c2ccsc2)nc1CC(=O)NCCCc1nnc2n1CCCCC2,3.320920000000002
+144403,Please optimize the molecule C[C@@H](NC(=O)[C@@H]1CCCN(C(=O)c2ccc(F)cc2)C1)C1CCCCC1 to have a lower LogP value.,C[C@@H](NC(=O)[C@@H]1CCCN(C(=O)c2ccc(F)cc2)C1)C1CCCCC1,3.762900000000003
+210473,Modify the molecule N#Cc1c(NC(=O)COc2ncnc3ccccc23)sc2c1CCC2 to have a lower LogP value.,N#Cc1c(NC(=O)COc2ncnc3ccccc23)sc2c1CCC2,3.069180000000001
+191111,Modify the molecule COc1cccc(N2C[C@@H](C(=O)N(C)Cc3ccsc3)CC2=O)c1 to have a lower LogP value.,COc1cccc(N2C[C@@H](C(=O)N(C)Cc3ccsc3)CC2=O)c1,2.768200000000001
+111446,Modify the molecule O=S(=O)(NCCCn1cncn1)c1ccc2c(c1)CCCC2 to have a higher LogP value.,O=S(=O)(NCCCn1cncn1)c1ccc2c(c1)CCCC2,1.5254999999999992
+132080,Modify the molecule COCC(=O)N1CCN(c2ccccc2C#N)CC1 to have a higher LogP value.,COCC(=O)N1CCN(c2ccccc2C#N)CC1,0.8532799999999998
+49694,Optimize the molecule CCOc1ccccc1CCC(=O)N1CCOC[C@@H]1C(N)=O to have a higher LogP value.,CCOc1ccccc1CCC(=O)N1CCOC[C@@H]1C(N)=O,0.7306000000000001
+22682,Optimize the molecule CN1C(=O)c2ccc(C(=O)Nc3cc([N+](=O)[O-])ccc3O)cc2C1=O to have a lower LogP value.,CN1C(=O)c2ccc(C(=O)Nc3cc([N+](=O)[O-])ccc3O)cc2C1=O,1.7784999999999997
+87106,Optimize the molecule Cc1ccc(-c2ncc(C[NH+]3CC[C@H](Cc4cnn(C)c4)C3)s2)cc1 to have a higher LogP value.,Cc1ccc(-c2ncc(C[NH+]3CC[C@H](Cc4cnn(C)c4)C3)s2)cc1,2.4995200000000004
+95725,Please modify the molecule CO[C@H](c1ccccc1)c1nc2nc(N(C)C)ccc2[nH]1 to increase its LogP value.,CO[C@H](c1ccccc1)c1nc2nc(N(C)C)ccc2[nH]1,2.7597000000000005
+143994,Optimize the molecule CC[C@H]1C[NH+](CC(C)(C)C)Cc2cc(OC)ccc2O1 to have a higher LogP value.,CC[C@H]1C[NH+](CC(C)(C)C)Cc2cc(OC)ccc2O1,2.2972
+197533,Please optimize the molecule CCn1cnc(S(=O)(=O)N[C@@H]2CCCC[C@@H]2[NH3+])c1 to have a higher LogP value.,CCn1cnc(S(=O)(=O)N[C@@H]2CCCC[C@@H]2[NH3+])c1,-0.26559999999999845
+196410,Please optimize the molecule CC(C)C[C@H](C(=O)NCc1cccc(CO)c1)N1CCCCC1=O to have a higher LogP value.,CC(C)C[C@H](C(=O)NCc1cccc(CO)c1)N1CCCCC1=O,2.2222999999999997
+190371,Please modify the molecule CCS(=O)(=O)c1ccc(C(=O)N(Cc2ccccn2)c2nc3c(C(C)C)cccc3s2)cc1 to increase its LogP value.,CCS(=O)(=O)c1ccc(C(=O)N(Cc2ccccn2)c2nc3c(C(C)C)cccc3s2)cc1,5.455300000000006
+228758,Please modify the molecule Cc1cccn2c(=O)c(/C=N/NC(N)=S)c(N3CCCC3)nc12 to increase its LogP value.,Cc1cccn2c(=O)c(/C=N/NC(N)=S)c(N3CCCC3)nc12,0.7702200000000005
+230958,Modify the molecule O=C(Nc1ccccc1Cl)C1CCN(S(=O)(=O)c2cccc(C(F)(F)F)c2)CC1 to increase its LogP value.,O=C(Nc1ccccc1Cl)C1CCN(S(=O)(=O)c2cccc(C(F)(F)F)c2)CC1,4.398200000000004
+113897,Optimize the molecule CCN(CCO)C(=O)NC[C@@H]1CC[NH+](C2CC2)C1 to have a higher LogP value.,CCN(CCO)C(=O)NC[C@@H]1CC[NH+](C2CC2)C1,-0.9225999999999974
+178541,Please optimize the molecule C[C@@H]1CN(c2ccc(N)cc2C(=O)[O-])C[C@H]1C to have a higher LogP value.,C[C@@H]1CN(c2ccc(N)cc2C(=O)[O-])C[C@H]1C,0.7244999999999998
+234843,Please modify the molecule Cc1ccc(Cc2nnc(NC(=O)c3cncc(C)c3)s2)cc1 to decrease its LogP value.,Cc1ccc(Cc2nnc(NC(=O)c3cncc(C)c3)s2)cc1,3.393040000000002
+102550,Please modify the molecule C[C@H](C1CC1)[NH+](C)CC(=O)NCCc1c(F)cccc1F to decrease its LogP value.,C[C@H](C1CC1)[NH+](C)CC(=O)NCCc1c(F)cccc1F,0.9366999999999999
+146988,Modify the molecule CC(=O)N1C=Cc2ccccc2[C@H]1CC(=O)N[C@@H](C)Cn1cc[nH+]c1 to have a higher LogP value.,CC(=O)N1C=Cc2ccccc2[C@H]1CC(=O)N[C@@H](C)Cn1cc[nH+]c1,1.7710999999999997
+61768,Modify the molecule Cc1noc(C)c1S(=O)(=O)N1CCCC[C@@H]1C(=O)Nc1ccc(Cl)c(Cl)c1 to increase its LogP value.,Cc1noc(C)c1S(=O)(=O)N1CCCC[C@@H]1C(=O)Nc1ccc(Cl)c(Cl)c1,3.780140000000002
+81932,Please modify the molecule [O-]c1nnc(-c2ccccn2)[nH]1 to decrease its LogP value.,[O-]c1nnc(-c2ccccn2)[nH]1,-0.05970000000000025
+145277,Modify the molecule Cc1nnnn1-c1cccc(C(=O)N2CCC3=C(C2)[C@H](C(C)C)N=N3)c1 to increase its LogP value.,Cc1nnnn1-c1cccc(C(=O)N2CCC3=C(C2)[C@H](C(C)C)N=N3)c1,2.5611200000000007
+47213,Please optimize the molecule O=C1NCCCC[C@H]1Oc1ccc(OC(=O)[C@@H]2CCCC[C@@H]2C(F)(F)F)cc1 to have a lower LogP value.,O=C1NCCCC[C@H]1Oc1ccc(OC(=O)[C@@H]2CCCC[C@@H]2C(F)(F)F)cc1,4.008200000000003
+138679,Please optimize the molecule Cc1cc([C@@H](C)NC(=O)NNC(=O)c2ccccc2O)cc(C)c1F to have a higher LogP value.,Cc1cc([C@@H](C)NC(=O)NNC(=O)c2ccccc2O)cc(C)c1F,2.853340000000001
+8687,Optimize the molecule C[C@@H]1C[C@H]1c1ccc(C[NH+](C)C2CCC([NH3+])CC2)o1 to have a higher LogP value.,C[C@@H]1C[C@H]1c1ccc(C[NH+](C)C2CCC([NH3+])CC2)o1,0.9708000000000012
+115889,Modify the molecule COc1cccc2c1OC[C@@H](NC(=O)C1(O)CCCC1)C2 to increase its LogP value.,COc1cccc2c1OC[C@@H](NC(=O)C1(O)CCCC1)C2,1.4199999999999997
+163044,Modify the molecule C[C@H]1CC(=O)c2cnn(-c3nc4ccccc4s3)c2C1 to increase its LogP value.,C[C@H]1CC(=O)c2cnn(-c3nc4ccccc4s3)c2C1,3.2470000000000026
+16305,Optimize the molecule C[NH2+][C@H](C)c1ccn(CC(=O)NC(C)(C)C)c1 to have a lower LogP value.,C[NH2+][C@H](C)c1ccn(CC(=O)NC(C)(C)C)c1,0.6569999999999996
+144540,Optimize the molecule Cc1cc(N2CCn3cc[nH+]c3C2)c([C@H](C)[NH3+])cc1F to have a higher LogP value.,Cc1cc(N2CCn3cc[nH+]c3C2)c([C@H](C)[NH3+])cc1F,1.07282
+203746,Please optimize the molecule CC[C@H](C)/[NH+]=C(/N)NCC(C)(C)N1CCOCC1 to have a lower LogP value.,CC[C@H](C)/[NH+]=C(/N)NCC(C)(C)N1CCOCC1,-1.1193999999999962
+73595,Optimize the molecule Cc1cccc(C)c1-n1nnnc1S[C@@H](C)C(=O)Nc1nc(C)c(C)s1 to have a lower LogP value.,Cc1cccc(C)c1-n1nnnc1S[C@@H](C)C(=O)Nc1nc(C)c(C)s1,3.4717800000000016
+86916,Please modify the molecule CSc1nc(Cl)cc(NCC2CCN(C(=O)OC(C)(C)C)CC2)n1 to increase its LogP value.,CSc1nc(Cl)cc(NCC2CCN(C(=O)OC(C)(C)C)CC2)n1,3.9109000000000025
+98047,Modify the molecule Cc1ccc(CN(CC[NH+](C)C)C(=O)Nc2ccc3c(c2)C(=O)NC3=O)o1 to have a higher LogP value.,Cc1ccc(CN(CC[NH+](C)C)C(=O)Nc2ccc3c(c2)C(=O)NC3=O)o1,0.6502199999999999
+128951,Please optimize the molecule CCOc1cc(C(=O)Nc2ccccc2N2CCOCC2)ccc1OC to have a higher LogP value.,CCOc1cc(C(=O)Nc2ccccc2N2CCOCC2)ccc1OC,3.182800000000002
+70616,Modify the molecule COc1cc(C(=S)NC[C@@H]2CCCO2)ccc1O to decrease its LogP value.,COc1cc(C(=S)NC[C@@H]2CCCO2)ccc1O,1.8448999999999995
+217862,Optimize the molecule C[NH2+]CCSCc1ccccc1 to have a higher LogP value.,C[NH2+]CCSCc1ccccc1,1.113
+175681,Modify the molecule CC1=NC(c2ccc(C[NH+](C)CC3CC[NH+](C)CC3)cc2)=NC(=O)[C@@H]1C to decrease its LogP value.,CC1=NC(c2ccc(C[NH+](C)CC3CC[NH+](C)CC3)cc2)=NC(=O)[C@@H]1C,0.009800000000004028
+136733,Please modify the molecule CC[C@@H]1CN(Cc2cn(C)nc2-c2ccc([N+](=O)[O-])cc2)CCN1CC(F)F to increase its LogP value.,CC[C@@H]1CN(Cc2cn(C)nc2-c2ccc([N+](=O)[O-])cc2)CCN1CC(F)F,3.156600000000002
+39366,Optimize the molecule O=C(N[C@H](CO)[C@H](O)c1ccc([N+](=O)[O-])cc1)c1ccc(Cl)cc1Cl to have a higher LogP value.,O=C(N[C@H](CO)[C@H](O)c1ccc([N+](=O)[O-])cc1)c1ccc(Cl)cc1Cl,2.725900000000001
+11420,Please optimize the molecule CC(C)(CNC(=O)c1cccc(C[NH+]2CCCC2)c1)NS(C)(=O)=O to have a lower LogP value.,CC(C)(CNC(=O)c1cccc(C[NH+]2CCCC2)c1)NS(C)(=O)=O,-0.07709999999999723
+237356,Optimize the molecule Cc1nc(C[C@@H]2CCC[NH+](Cc3ccn(Cc4ccccc4)c3)C2)no1 to have a lower LogP value.,Cc1nc(C[C@@H]2CCC[NH+](Cc3ccn(Cc4ccccc4)c3)C2)no1,2.2654199999999998
+90475,Modify the molecule COc1ccccc1-n1c(SCC(=O)N2CCCC[C@H]2C)nc2sc3c(c2c1=O)CCCC3 to increase its LogP value.,COc1ccccc1-n1c(SCC(=O)N2CCCC[C@H]2C)nc2sc3c(c2c1=O)CCCC3,4.827700000000005
+80787,Optimize the molecule CCCCC[C@H](C)n1c([C@@H](C)Cl)nc2c(C)ccnc21 to have a lower LogP value.,CCCCC[C@H](C)n1c([C@@H](C)Cl)nc2c(C)ccnc21,5.180820000000005
+98921,Modify the molecule CCc1ccc(C(=O)Nc2ccc(CC(=O)N3CC[NH+](CC)CC3)cc2)o1 to decrease its LogP value.,CCc1ccc(C(=O)Nc2ccc(CC(=O)N3CC[NH+](CC)CC3)cc2)o1,1.3838000000000006
+204474,Optimize the molecule CC1(C)C(C(=O)N2C[C@@H]3C[NH2+]C[C@@H]3C2)C1(C)C to have a higher LogP value.,CC1(C)C(C(=O)N2C[C@@H]3C[NH2+]C[C@@H]3C2)C1(C)C,0.3202000000000007
+159437,Modify the molecule Cc1nnc(NC(=O)c2ccccc2OCc2ccc(Cl)cc2)o1 to have a lower LogP value.,Cc1nnc(NC(=O)c2ccccc2OCc2ccc(Cl)cc2)o1,3.862720000000002
+59691,Please optimize the molecule CN(Cc1cccc(-n2cccn2)c1)C(=O)c1cc(=O)n(-c2ccccc2)[nH]1 to have a higher LogP value.,CN(Cc1cccc(-n2cccn2)c1)C(=O)c1cc(=O)n(-c2ccccc2)[nH]1,2.6235
+242561,Modify the molecule O=C(NCCCCn1cnnc1)c1c(F)cccc1F to have a higher LogP value.,O=C(NCCCCn1cnnc1)c1c(F)cccc1F,1.7665
+147538,Modify the molecule COc1ccc(OC)c(S(=O)(=O)N2CCN=C2c2ccccc2)c1 to increase its LogP value.,COc1ccc(OC)c(S(=O)(=O)N2CCN=C2c2ccccc2)c1,2.1549000000000005
+137298,Modify the molecule CCc1ccc(NC(=S)N2CCOCC2)cc1 to decrease its LogP value.,CCc1ccc(NC(=S)N2CCOCC2)cc1,2.2780000000000005
+52882,Please optimize the molecule COc1cc(OC)cc([C@H]2CCN(C(=O)C3=Cc4ccccc4OC3)C2)c1 to have a higher LogP value.,COc1cc(OC)cc([C@H]2CCN(C(=O)C3=Cc4ccccc4OC3)C2)c1,3.495700000000002
+120204,Please modify the molecule CNc1nc2ccccc2cc1CSC[C@@H](O)CO to increase its LogP value.,CNc1nc2ccccc2cc1CSC[C@@H](O)CO,1.8628999999999993
+217895,Modify the molecule CCC[C@@H]1C[C@@]1(O)[C@@H]1CCOC1 to increase its LogP value.,CCC[C@@H]1C[C@@]1(O)[C@@H]1CCOC1,1.574
+59755,Please optimize the molecule CCC[C@@H](Cc1ccc2nccnc2n1)[NH2+]CC to have a higher LogP value.,CCC[C@@H](Cc1ccc2nccnc2n1)[NH2+]CC,1.3193000000000001
+117653,Optimize the molecule O=C([O-])[C@H](Cc1cccc(F)c1)CC1CC1 to have a higher LogP value.,O=C([O-])[C@H](Cc1cccc(F)c1)CC1CC1,1.5343999999999993
+240024,Please modify the molecule C[C@@H](Oc1ccc(-c2ccccc2)cc1)C(=O)Nc1nc(C#N)c(C#N)[n-]1 to increase its LogP value.,C[C@@H](Oc1ccc(-c2ccccc2)cc1)C(=O)Nc1nc(C#N)c(C#N)[n-]1,2.8551599999999997
+151382,Please optimize the molecule Cn1ncnc1CCNC(=O)CCn1c([S-])nnc1-c1cccs1 to have a lower LogP value.,Cn1ncnc1CCNC(=O)CCn1c([S-])nnc1-c1cccs1,0.7898999999999996
+75605,Modify the molecule CC(C)C[NH+](CC(C)C)[C@H]1CC[C@@](C#N)(NC2CC2)C1 to have a higher LogP value.,CC(C)C[NH+](CC(C)C)[C@H]1CC[C@@](C#N)(NC2CC2)C1,1.7501799999999994
+245942,Modify the molecule Cc1ccc(C[NH2+][C@@H](C)CCN2CCOCC2)nc1 to decrease its LogP value.,Cc1ccc(C[NH2+][C@@H](C)CCN2CCOCC2)nc1,0.564220000000001
+241275,Please modify the molecule Cc1cc(C(=O)CCC(=O)N[C@H](C#N)c2ccccc2C)c(C)s1 to decrease its LogP value.,Cc1cc(C(=O)CCC(=O)N[C@H](C#N)c2ccccc2C)c(C)s1,4.0173400000000035
+39088,Modify the molecule Cc1ccc(-c2nc3ccccc3c(=O)n2CS(=O)(=O)c2ccccc2)cc1 to have a lower LogP value.,Cc1ccc(-c2nc3ccccc3c(=O)n2CS(=O)(=O)c2ccccc2)cc1,3.803320000000003
+143477,Please modify the molecule CCCC[C@@H](COC)NC(=O)c1c[nH]c(C)cc1=O to decrease its LogP value.,CCCC[C@@H](COC)NC(=O)c1c[nH]c(C)cc1=O,1.61832
+224049,Modify the molecule Cc1cnc(Cl)nc1N[C@@H](C)C(C)C to decrease its LogP value.,Cc1cnc(Cl)nc1N[C@@H](C)C(C)C,2.894820000000001
+14197,Modify the molecule OCc1ccc(-c2ccnc(F)c2)cc1 to increase its LogP value.,OCc1ccc(-c2ccnc(F)c2)cc1,2.38
+183298,Modify the molecule COc1cccc(OC)c1C(=O)Nc1ccccc1N1CCN(C(=O)c2ccccc2)CC1 to decrease its LogP value.,COc1cccc(OC)c1C(=O)Nc1ccccc1N1CCN(C(=O)c2ccccc2)CC1,3.9185000000000034
+181281,Modify the molecule C[C@H]1CCCC[C@H]1[NH2+]C[C@H](C(=O)N1CCOCC1)c1ccccc1 to decrease its LogP value.,C[C@H]1CCCC[C@H]1[NH2+]C[C@H](C(=O)N1CCOCC1)c1ccccc1,1.7711000000000006
+1258,Optimize the molecule CCC[NH+](CCO)C[C@H]1[C@H](N)C(C)(C)OC1(C)C to have a higher LogP value.,CCC[NH+](CCO)C[C@H]1[C@H](N)C(C)(C)OC1(C)C,-0.19549999999999734
+24090,Optimize the molecule CCOC(=O)c1c(C)oc2ncn(C[C@H](O)Cn3c4ccccc4c4ccccc43)c(=O)c12 to have a lower LogP value.,CCOC(=O)c1c(C)oc2ncn(C[C@H](O)Cn3c4ccccc4c4ccccc43)c(=O)c12,3.643620000000002
+14568,Modify the molecule CC[C@H]1C[NH2+][C@H](Cc2ccccc2)CN1c1ccn(C)n1 to have a lower LogP value.,CC[C@H]1C[NH2+][C@H](Cc2ccccc2)CN1c1ccn(C)n1,1.1933999999999994
+140750,Please optimize the molecule CCN(CC1CC1)C(=O)c1cc2c(C)cc(C)cc2[nH]1 to have a lower LogP value.,CCN(CC1CC1)C(=O)c1cc2c(C)cc(C)cc2[nH]1,3.6568400000000025
+155853,Please optimize the molecule COc1ccc([C@@H](NC(=O)[C@H](C)n2cncn2)C2CCOCC2)cc1 to have a lower LogP value.,COc1ccc([C@@H](NC(=O)[C@H](C)n2cncn2)C2CCOCC2)cc1,2.1318
+174915,Please optimize the molecule Cc1cccc2c1N(C(=O)c1ccc(S(=O)(=O)N3C[C@@H](C)O[C@H](C)C3)cc1)CCC2 to have a higher LogP value.,Cc1cccc2c1N(C(=O)c1ccc(S(=O)(=O)N3C[C@@H](C)O[C@H](C)C3)cc1)CCC2,3.3859200000000023
+8712,Please optimize the molecule Cc1ccccc1N1CCN(CC(=O)Nc2cccc(Cl)c2Cl)CC1 to have a lower LogP value.,Cc1ccccc1N1CCN(CC(=O)Nc2cccc(Cl)c2Cl)CC1,4.062520000000003
+116784,Modify the molecule C[C@]12CCC(=O)N1[C@H](C(=O)N1CCC[C@@H]1C(=O)[O-])CS2 to have a lower LogP value.,C[C@]12CCC(=O)N1[C@H](C(=O)N1CCC[C@@H]1C(=O)[O-])CS2,-0.8186999999999993
+73694,Please optimize the molecule Cc1cc(C)n(C[C@@H](C)CNC(=O)C(=O)Nc2ccc3nc(C)oc3c2)n1 to have a higher LogP value.,Cc1cc(C)n(C[C@@H](C)CNC(=O)C(=O)Nc2ccc3nc(C)oc3c2)n1,2.34056
+234776,Please optimize the molecule CSc1ccc(-c2nccn2CCS(=O)(=O)CC(C)C)cc1 to have a higher LogP value.,CSc1ccc(-c2nccn2CCS(=O)(=O)CC(C)C)cc1,3.3428000000000013
+133707,Modify the molecule CC[NH2+][C@@H](Cc1cccc(C)c1)C1([NH+](C)C)CCCCC1 to increase its LogP value.,CC[NH2+][C@@H](Cc1cccc(C)c1)C1([NH+](C)C)CCCCC1,1.33682
+188087,Optimize the molecule C=CCOc1ccc([C@@H]2NC(=O)c3ccccc3N2C)cc1 to have a lower LogP value.,C=CCOc1ccc([C@@H]2NC(=O)c3ccccc3N2C)cc1,3.129800000000002
+233420,Please modify the molecule CCc1nc(Oc2cccc(F)c2)c2oc3ccccc3c2n1 to decrease its LogP value.,CCc1nc(Oc2cccc(F)c2)c2oc3ccccc3c2n1,4.869800000000003
+104992,Please modify the molecule CC(C)(C)SC[C@H]([NH3+])[C@@H]1CCc2cccnc21 to increase its LogP value.,CC(C)(C)SC[C@H]([NH3+])[C@@H]1CCc2cccnc21,2.2536000000000005
+109442,Modify the molecule COc1ccc(OCC(=O)N[C@@H](C)c2ccc(F)c(F)c2)cc1 to increase its LogP value.,COc1ccc(OCC(=O)N[C@@H](C)c2ccc(F)c(F)c2)cc1,3.2296000000000022
+44995,Modify the molecule CC(=O)N1CCOc2ccc(S(=O)(=O)NCc3ccc4c(c3)OCO4)cc21 to have a higher LogP value.,CC(=O)N1CCOc2ccc(S(=O)(=O)NCc3ccc4c(c3)OCO4)cc21,1.6390999999999996
+44554,Optimize the molecule COCCCN1C(=O)c2ccc(-c3ccco3)n2C[C@@]1(C)C(=O)N[C@@H]1CCCC[C@H]1C to have a lower LogP value.,COCCCN1C(=O)c2ccc(-c3ccco3)n2C[C@@]1(C)C(=O)N[C@@H]1CCCC[C@H]1C,3.6940000000000026
+122813,Optimize the molecule CCc1ccc(S(=O)(=O)Oc2ccc(C#N)cc2[N+](=O)[O-])s1 to have a lower LogP value.,CCc1ccc(S(=O)(=O)Oc2ccc(C#N)cc2[N+](=O)[O-])s1,2.858080000000001
+85636,Optimize the molecule COc1ccc(OC)c(CN2CCCn3cccc3[C@H]2c2ccccc2C)c1 to have a lower LogP value.,COc1ccc(OC)c(CN2CCCn3cccc3[C@H]2c2ccccc2C)c1,4.809020000000005
+138066,Modify the molecule Cc1ccc(-n2ncc(C(=O)O[C@H](C)[C@H]3CCOC3)c2C(F)(F)F)cc1 to decrease its LogP value.,Cc1ccc(-n2ncc(C(=O)O[C@H](C)[C@H]3CCOC3)c2C(F)(F)F)cc1,3.7813200000000027
+169524,Modify the molecule COC(=O)C1=C([O-])N=C(SCC(=O)Nc2ccc3ccccc3c2)[C@@H](C#N)[C@@H]1c1ccc(C)cc1 to have a higher LogP value.,COC(=O)C1=C([O-])N=C(SCC(=O)Nc2ccc3ccccc3c2)[C@@H](C#N)[C@@H]1c1ccc(C)cc1,3.9005000000000027
+224559,Modify the molecule Cc1ccc(-c2ncco2)cc1NC(=O)NCCC(=O)OC(C)C to increase its LogP value.,Cc1ccc(-c2ncco2)cc1NC(=O)NCCC(=O)OC(C)C,3.113220000000002
+221069,Modify the molecule COc1ccc([C@H]([NH2+]C[C@H](C)SC)C2CC2)cc1 to have a higher LogP value.,COc1ccc([C@H]([NH2+]C[C@H](C)SC)C2CC2)cc1,2.4612000000000007
+26852,Please modify the molecule CCOC(=O)C[NH2+]C[C@@H]1CSc2ccccc21 to decrease its LogP value.,CCOC(=O)C[NH2+]C[C@@H]1CSc2ccccc21,1.0023999999999993
+40460,Optimize the molecule COc1cc(Br)c(/C=C(\C#N)C(=O)Nc2cccc(Cl)c2C)cc1OC to have a higher LogP value.,COc1cc(Br)c(/C=C(\C#N)C(=O)Nc2cccc(Cl)c2C)cc1OC,4.973800000000002
+10549,Modify the molecule Cn1cnn(-c2ccc(NC(=O)[C@@H]3COc4ccccc4O3)cc2)c1=O to have a higher LogP value.,Cn1cnn(-c2ccc(NC(=O)[C@@H]3COc4ccccc4O3)cc2)c1=O,1.3494999999999995
+163774,Optimize the molecule O=C1C=C/C(=N\c2ccc3c(c2)Cc2cc(Br)ccc2-3)O1 to have a lower LogP value.,O=C1C=C/C(=N\c2ccc3c(c2)Cc2cc(Br)ccc2-3)O1,4.163300000000002
+220676,Please modify the molecule COc1ccc(C(=O)C(=O)Nc2ccc(F)c(C(=O)N(C)C)c2)cc1 to decrease its LogP value.,COc1ccc(C(=O)C(=O)Nc2ccc(F)c(C(=O)N(C)C)c2)cc1,2.3575
+145692,Optimize the molecule Nc1nccnc1C(=O)NCc1ccccc1CN1CCN(c2ccccc2)CC1 to have a higher LogP value.,Nc1nccnc1C(=O)NCc1ccccc1CN1CCN(c2ccccc2)CC1,2.311
+113994,Modify the molecule C/C(=N/O)c1cc(F)ccc1OCc1c(Cl)cccc1Cl to have a lower LogP value.,C/C(=N/O)c1cc(F)ccc1OCc1c(Cl)cccc1Cl,4.909700000000003
+135060,Optimize the molecule C[C@H](c1ccncc1)[NH+](C)CC(=O)N[C@@H](c1ccc(F)cc1)C1CCCC1 to have a higher LogP value.,C[C@H](c1ccncc1)[NH+](C)CC(=O)N[C@@H](c1ccc(F)cc1)C1CCCC1,2.844100000000001
+219936,Modify the molecule COc1ccc(Nc2nc(C(=O)NC3CCCC3)cs2)cc1 to have a lower LogP value.,COc1ccc(Nc2nc(C(=O)NC3CCCC3)cs2)cc1,3.567700000000002
+13845,Please optimize the molecule C[C@@H]1C[C@@H]1C(=O)Nc1cccc(F)c1I to have a lower LogP value.,C[C@@H]1C[C@@H]1C(=O)Nc1cccc(F)c1I,3.024800000000001
+248572,Optimize the molecule CC[NH2+][C@H]1CCCC[C@@H](C[C@@H]2CSc3ccccc32)C1 to have a higher LogP value.,CC[NH2+][C@H]1CCCC[C@@H](C[C@@H]2CSc3ccccc32)C1,3.798200000000003
+146461,Modify the molecule CC(C)(C)[C@@H](C#N)NC(=O)c1ccc2c(c1)COCO2 to have a lower LogP value.,CC(C)(C)[C@@H](C#N)NC(=O)c1ccc2c(c1)COCO2,2.2211800000000004
+194972,Please modify the molecule CSc1ccc(C(=O)Nc2ccc3c(c2)CCCN3C(C)=O)cn1 to increase its LogP value.,CSc1ccc(C(=O)Nc2ccc3c(c2)CCCN3C(C)=O)cn1,3.3549000000000015
+4382,Optimize the molecule COc1cc(NS(=O)(=O)c2ccc(N3C(=O)[C@H]4[C@@H]5C=C[C@@H](C5)[C@@H]4C3=O)cc2)nc(OC)n1 to have a lower LogP value.,COc1cc(NS(=O)(=O)c2ccc(N3C(=O)[C@H]4[C@@H]5C=C[C@@H](C5)[C@@H]4C3=O)cc2)nc(OC)n1,1.6060999999999999
+195546,Modify the molecule [NH3+]C1(C(=O)N2CCC3(CCC(=O)N(CCc4ccncc4)C3)CC2)CC1 to decrease its LogP value.,[NH3+]C1(C(=O)N2CCC3(CCC(=O)N(CCc4ccncc4)C3)CC2)CC1,0.6297999999999999
+224193,Optimize the molecule CCc1nn2c(nnc3c(=O)n(Cc4cccnc4)ccc32)c1-c1ccc(F)cc1 to have a higher LogP value.,CCc1nn2c(nnc3c(=O)n(Cc4cccnc4)ccc32)c1-c1ccc(F)cc1,3.2510000000000012
+143435,Please optimize the molecule CCOc1ccccc1CNC(=O)[C@H]1C[C@H]2CC[C@@H]1O2 to have a higher LogP value.,CCOc1ccccc1CNC(=O)[C@H]1C[C@H]2CC[C@@H]1O2,2.269
+178074,Modify the molecule CC(C)c1csc(CNC(=O)NCC2(c3ccc(F)cc3F)CC2)n1 to have a higher LogP value.,CC(C)c1csc(CNC(=O)NCC2(c3ccc(F)cc3F)CC2)n1,4.075700000000002
+75116,Modify the molecule Cc1ccc(NC(=O)NCCC(C)C)c(OCC(=O)N(C)C)c1 to have a lower LogP value.,Cc1ccc(NC(=O)NCCC(C)C)c(OCC(=O)N(C)C)c1,2.629620000000001
+61462,Modify the molecule CC(C)C[NH2+]C[C@@]1(S(C)(=O)=O)CCC[C@H]1C to increase its LogP value.,CC(C)C[NH2+]C[C@@]1(S(C)(=O)=O)CCC[C@H]1C,0.8092000000000006
+75857,Modify the molecule CC[C@@H](CCO)CNc1nccn(C(C)C)c1=O to have a lower LogP value.,CC[C@@H](CCO)CNc1nccn(C(C)C)c1=O,1.6446999999999998
+7226,Optimize the molecule CCN(CC(=O)OC)C(=O)C1[C@H]2CCCC[C@@H]12 to have a higher LogP value.,CCN(CC(=O)OC)C(=O)C1[C@H]2CCCC[C@@H]12,1.4440999999999995
+193989,Modify the molecule C[C@H](C(=O)N1CCCCC1)[NH+]1CCN(CCC[NH3+])CC1 to have a lower LogP value.,C[C@H](C(=O)N1CCCCC1)[NH+]1CCN(CCC[NH3+])CC1,-1.7800999999999951
+225248,Please modify the molecule CCOC(=O)c1c(NC(=O)c2cc(-c3ccccc3)nc3ccccc23)sc2c1CCN(C(C)=O)C2 to decrease its LogP value.,CCOC(=O)c1c(NC(=O)c2cc(-c3ccccc3)nc3ccccc23)sc2c1CCN(C(C)=O)C2,5.296900000000004
+104946,Modify the molecule CCNC(=O)c1ccc(NC(=O)N2CCC[C@H]2c2ccccc2OC)cc1 to increase its LogP value.,CCNC(=O)c1ccc(NC(=O)N2CCC[C@H]2c2ccccc2OC)cc1,3.813900000000003
+107879,Optimize the molecule C[C@H](NC(=O)c1ccc(Cl)cc1)C(=O)N(C)[C@@H](C)c1ccco1 to have a higher LogP value.,C[C@H](NC(=O)c1ccc(Cl)cc1)C(=O)N(C)[C@@H](C)c1ccco1,3.270900000000002
+117305,Modify the molecule C[C@@H](Sc1nnnn1C[C@@H]1CCCO1)C(=O)N1c2ccccc2NC(=O)C1(C)C to decrease its LogP value.,C[C@@H](Sc1nnnn1C[C@@H]1CCCO1)C(=O)N1c2ccccc2NC(=O)C1(C)C,2.0965999999999996
+141579,Please modify the molecule CSc1ccc([N+](=O)[O-])c(C(=O)N[C@@H]2[C@@H]3CCO[C@@H]3C2(C)C)c1 to decrease its LogP value.,CSc1ccc([N+](=O)[O-])c(C(=O)N[C@@H]2[C@@H]3CCO[C@@H]3C2(C)C)c1,2.860000000000002
+223531,Modify the molecule C[C@H](NC(=O)c1ccc(S(=O)(=O)NC2CC2)cc1)c1ccccc1Br to increase its LogP value.,C[C@H](NC(=O)c1ccc(S(=O)(=O)NC2CC2)cc1)c1ccccc1Br,3.3808000000000025
+76677,Modify the molecule CN(CC(=O)N[C@H]1CCCc2ccccc21)S(=O)(=O)c1ccc2c(c1)c(=O)n(C)c(=O)n2C to have a higher LogP value.,CN(CC(=O)N[C@H]1CCCc2ccccc21)S(=O)(=O)c1ccc2c(c1)c(=O)n(C)c(=O)n2C,1.051499999999999
+161591,Please optimize the molecule Cc1ccc(CC(=O)N2CCC[NH+](Cc3ccc(F)cc3)CC2)cc1 to have a higher LogP value.,Cc1ccc(CC(=O)N2CCC[NH+](Cc3ccc(F)cc3)CC2)cc1,1.9940199999999997
+122166,Modify the molecule O=C(NCc1csc(Br)c1)NCc1ccco1 to have a higher LogP value.,O=C(NCc1csc(Br)c1)NCc1ccco1,3.1030000000000015
+138445,Modify the molecule C[NH2+][C@]1(C(=O)[O-])CCC[C@H]([NH+](C)C2CC2)C1 to have a lower LogP value.,C[NH2+][C@]1(C(=O)[O-])CCC[C@H]([NH+](C)C2CC2)C1,-2.711999999999996
+92904,Modify the molecule COc1ccc(NC(=O)NC[C@@H](O)c2ccc(Cl)cc2)c(C)c1 to have a lower LogP value.,COc1ccc(NC(=O)NC[C@@H](O)c2ccc(Cl)cc2)c(C)c1,3.5121200000000012
+41554,Please optimize the molecule Cc1ncccc1NC(=O)C(=O)NC[C@@H]1CCCc2ccccc21 to have a lower LogP value.,Cc1ncccc1NC(=O)C(=O)NC[C@@H]1CCCc2ccccc21,2.56482
+188468,Modify the molecule c1ccc(C[C@H]2C[NH+]3CCC[C@H]3CN2Cc2cncn2Cc2ccccc2)cc1 to increase its LogP value.,c1ccc(C[C@H]2C[NH+]3CCC[C@H]3CN2Cc2cncn2Cc2ccccc2)cc1,2.4056000000000006
+124635,Modify the molecule O=[N+]([O-])c1cccc(CCN[C@@H]2CC[NH+](C3CC3)C2)c1 to have a lower LogP value.,O=[N+]([O-])c1cccc(CCN[C@@H]2CC[NH+](C3CC3)C2)c1,0.5465000000000004
+219777,Please optimize the molecule CCOc1ccc(NC(=O)NCc2ccccc2Cn2cccn2)cc1F to have a lower LogP value.,CCOc1ccc(NC(=O)NCc2ccccc2Cn2cccn2)cc1F,3.7909000000000024
+88347,Modify the molecule C=C(Cl)Cc1ccccn1 to have a higher LogP value.,C=C(Cl)Cc1ccccn1,2.3766
+124701,Please optimize the molecule COC[C@@H](NC(=O)C[C@@H](O)c1cc(Cl)cc(Cl)c1)c1ccccc1 to have a lower LogP value.,COC[C@@H](NC(=O)C[C@@H](O)c1cc(Cl)cc(Cl)c1)c1ccccc1,3.9208000000000025
+27335,Modify the molecule CN(C1CCC(C)(C)CC1)S(=O)(=O)c1ccc(S(N)(=O)=O)cc1 to have a higher LogP value.,CN(C1CCC(C)(C)CC1)S(=O)(=O)c1ccc(S(N)(=O)=O)cc1,1.9232999999999998
+126920,Optimize the molecule CCOCc1ccc(NC(=O)C(=O)N(C)Cc2ccc(C#N)cc2)cc1 to have a higher LogP value.,CCOCc1ccc(NC(=O)C(=O)N(C)Cc2ccc(C#N)cc2)cc1,2.691880000000001
+47407,Modify the molecule CS(=O)(=O)N[C@@H]1CCC[NH+](CCc2ccc(OC(F)(F)F)cc2)C1 to have a lower LogP value.,CS(=O)(=O)N[C@@H]1CCC[NH+](CCc2ccc(OC(F)(F)F)cc2)C1,0.7242
+120047,Please modify the molecule CCc1nnc([O-])c(C(=O)N[C@@H](C)c2nc3ccccc3[nH]2)c1CC to decrease its LogP value.,CCc1nnc([O-])c(C(=O)N[C@@H](C)c2nc3ccccc3[nH]2)c1CC,2.0423
+151391,Modify the molecule O=C(NCc1cccs1)c1cccc(S(=O)(=O)N2CCCC2)c1 to have a higher LogP value.,O=C(NCc1cccs1)c1cccc(S(=O)(=O)N2CCCC2)c1,2.462600000000001
+95642,Please optimize the molecule COc1cc(OC)cc(-c2cc3nc(C)c(CCC(=O)[O-])c(C)n3n2)c1 to have a higher LogP value.,COc1cc(OC)cc(-c2cc3nc(C)c(CCC(=O)[O-])c(C)n3n2)c1,1.7128399999999997
+186235,Please modify the molecule O=C1NCC=Cc2c1[nH]c(Br)c2Br to decrease its LogP value.,O=C1NCC=Cc2c1[nH]c(Br)c2Br,2.2963
+123143,Please modify the molecule Cn1c(=O)c2c(-c3ccc(Cl)cc3)n(CC(=O)[O-])cc2n(C)c1=O to decrease its LogP value.,Cn1c(=O)c2c(-c3ccc(Cl)cc3)n(CC(=O)[O-])cc2n(C)c1=O,0.10899999999999954
+248167,Modify the molecule Cc1cccc(C(C)C)c1NC(=O)c1ccc2c([O-])n(C)c(=S)nc2c1 to have a higher LogP value.,Cc1cccc(C(C)C)c1NC(=O)c1ccc2c([O-])n(C)c(=S)nc2c1,4.0605100000000025
+25254,Modify the molecule Cc1ccc(C)n1-c1ccc(C(=O)N[C@H]2CCS(=O)(=O)C2)cc1 to have a lower LogP value.,Cc1ccc(C)n1-c1ccc(C(=O)N[C@H]2CCS(=O)(=O)C2)cc1,2.01104
+203240,Optimize the molecule Cc1ccc(S(=O)(=O)N2CCN(CC(=O)Nc3ccc(C)c(C)c3)CC2)c(C)c1 to have a lower LogP value.,Cc1ccc(S(=O)(=O)N2CCN(CC(=O)Nc3ccc(C)c(C)c3)CC2)c(C)c1,2.865280000000002
+204142,Modify the molecule CC(C)c1cnc(C[NH+]2CCN(CCN3C(=O)CCC3=O)CC2)o1 to decrease its LogP value.,CC(C)c1cnc(C[NH+]2CCN(CCN3C(=O)CCC3=O)CC2)o1,-0.3524999999999969
+228449,Please optimize the molecule COc1ccc(OC)c(NC(=O)c2cc(-c3ccc(F)cc3)oc2C)c1 to have a lower LogP value.,COc1ccc(OC)c(NC(=O)c2cc(-c3ccc(F)cc3)oc2C)c1,4.663620000000003
+166027,Modify the molecule CSCc1ccnc(N2CCO[C@H](c3ccc(C)cc3C)C2)c1 to have a lower LogP value.,CSCc1ccnc(N2CCO[C@H](c3ccc(C)cc3C)C2)c1,4.139340000000003
+245011,Optimize the molecule O=C(Nc1ccc(I)cc1)c1cccc(-n2cnnc2)n1 to have a higher LogP value.,O=C(Nc1ccc(I)cc1)c1cccc(-n2cnnc2)n1,2.5191999999999997
+218107,Please optimize the molecule CSCc1nnc(NC(=O)c2ccc(S(=O)(=O)N3CCCCCC3)cc2)o1 to have a lower LogP value.,CSCc1nnc(NC(=O)c2ccc(S(=O)(=O)N3CCCCCC3)cc2)o1,2.749600000000001
+211087,Modify the molecule Cc1nc(Nc2ncnc(Nc3ccc4c(c3)OCO4)c2[N+](=O)[O-])sc1C to have a higher LogP value.,Cc1nc(Nc2ncnc(Nc3ccc4c(c3)OCO4)c2[N+](=O)[O-])sc1C,3.6740400000000015
+93623,Please optimize the molecule C[C@H](NS(=O)(=O)c1ccc(Cl)cc1)C(=O)Nc1ccc(Cl)cc1 to have a higher LogP value.,C[C@H](NS(=O)(=O)c1ccc(Cl)cc1)C(=O)Nc1ccc(Cl)cc1,3.2989000000000015
+197892,Optimize the molecule COc1cccc([C@@H]2CN(C(=O)c3cnn(C)c3)C[C@H]2C(=O)[O-])c1OC to have a lower LogP value.,COc1cccc([C@@H]2CN(C(=O)c3cnn(C)c3)C[C@H]2C(=O)[O-])c1OC,0.043000000000000815
+40752,Modify the molecule COc1ccccc1N1CCN(C(=O)c2cccc(S(=O)(=O)N3c4ccccc4C[C@H]3C)c2)CC1 to decrease its LogP value.,COc1ccccc1N1CCN(C(=O)c2cccc(S(=O)(=O)N3c4ccccc4C[C@H]3C)c2)CC1,3.797500000000003
+53459,Modify the molecule Cc1cnn(-c2ccccc2)c1NC(=O)[C@H]1COc2ccc(F)cc2C1 to have a lower LogP value.,Cc1cnn(-c2ccccc2)c1NC(=O)[C@H]1COc2ccc(F)cc2C1,3.5096200000000017
+93590,Please optimize the molecule Cc1nc2n(n1)C[C@H]([NH2+][C@@H](C)C(=O)Nc1cc(C)on1)CC2 to have a higher LogP value.,Cc1nc2n(n1)C[C@H]([NH2+][C@@H](C)C(=O)Nc1cc(C)on1)CC2,-0.2116599999999993
+117525,Modify the molecule COc1cc(C)ccc1NCC(=O)Nc1ccc(F)c(F)c1 to increase its LogP value.,COc1cc(C)ccc1NCC(=O)Nc1ccc(F)c(F)c1,3.332420000000001
+143590,Optimize the molecule COc1cccc(OC)c1C(=O)N1CCN(C(=O)c2cc3cc(C)ccc3n2C)CC1 to have a lower LogP value.,COc1cccc(OC)c1C(=O)N1CCN(C(=O)c2cc3cc(C)ccc3n2C)CC1,3.102120000000002
+118541,Please modify the molecule CCc1ccc([C@@H](C)NC(=O)[C@@H](C)Sc2nnc(C)c(=O)n2N)cc1 to decrease its LogP value.,CCc1ccc([C@@H](C)NC(=O)[C@@H](C)Sc2nnc(C)c(=O)n2N)cc1,1.5809199999999997
+240814,Optimize the molecule C[C@@H]1c2ccc(O)cc2OC(=O)[C@@H]1CC(=O)NC1=CC2=CC=N[C@@H]2C=C1 to have a lower LogP value.,C[C@@H]1c2ccc(O)cc2OC(=O)[C@@H]1CC(=O)NC1=CC2=CC=N[C@@H]2C=C1,2.3703000000000003
+14849,Please modify the molecule COC(=O)[C@@H]1CN(C(=O)Nc2cncc3ccccc23)C[C@H]1C to increase its LogP value.,COC(=O)[C@@H]1CN(C(=O)Nc2cncc3ccccc23)C[C@H]1C,2.507600000000001
+99809,Please optimize the molecule C[C@@H](CCO)CNc1ncnc2ccc(F)cc12 to have a higher LogP value.,C[C@@H](CCO)CNc1ncnc2ccc(F)cc12,2.1993
+205795,Please modify the molecule C[C@]1(C(=O)N2CCC(CC(=O)[O-])CC2)CCC[NH2+]C1 to increase its LogP value.,C[C@]1(C(=O)N2CCC(CC(=O)[O-])CC2)CCC[NH2+]C1,-1.2714999999999967
+226300,Please modify the molecule C[C@@H]1CC[C@H](NC(=O)[C@@H]2CC[C@@H]3CCCC[C@@H]3[NH2+]2)[C@@H]1C to increase its LogP value.,C[C@@H]1CC[C@H](NC(=O)[C@@H]2CC[C@@H]3CCCC[C@@H]3[NH2+]2)[C@@H]1C,1.8218
+174788,Modify the molecule CC(C)n1cc(S(=O)(=O)N[C@@H](CC(F)(F)F)c2ccc(F)cc2)cn1 to have a lower LogP value.,CC(C)n1cc(S(=O)(=O)N[C@@H](CC(F)(F)F)c2ccc(F)cc2)cn1,3.5751000000000017
+130915,Optimize the molecule O=C(CCN1C(=O)/C(=C/c2ccccc2O)SC1=S)Nc1ccc(Cl)cc1 to have a lower LogP value.,O=C(CCN1C(=O)/C(=C/c2ccccc2O)SC1=S)Nc1ccc(Cl)cc1,4.2756000000000025
+248004,Modify the molecule CCC[C@@H]1C[C@@H](Nc2cc(OC)ccc2F)CCO1 to have a lower LogP value.,CCC[C@@H]1C[C@@H](Nc2cc(OC)ccc2F)CCO1,3.5939000000000023
+194032,Optimize the molecule O=S(=O)(NCc1ccccc1)c1ccc(-c2cnc(C3CC3)o2)s1 to have a higher LogP value.,O=S(=O)(NCc1ccccc1)c1ccc(-c2cnc(C3CC3)o2)s1,3.759000000000003
+212242,Modify the molecule CCCN1C(=O)CCc2cc(NC(=O)NC[C@H](O)c3cnn(C)c3)ccc21 to have a lower LogP value.,CCCN1C(=O)CCc2cc(NC(=O)NC[C@H](O)c3cnn(C)c3)ccc21,1.964399999999999
+171261,Please optimize the molecule CC[NH+]1CCN(CCNC(=O)c2sc(-n3cccc3)nc2C(C)C)CC1 to have a higher LogP value.,CC[NH+]1CCN(CCNC(=O)c2sc(-n3cccc3)nc2C(C)C)CC1,1.0074000000000007
+57961,Modify the molecule C[NH2+][C@H](Cc1ccccc1Br)C(C)(C)N1CCOCC1 to decrease its LogP value.,C[NH2+][C@H](Cc1ccccc1Br)C(C)(C)N1CCOCC1,1.6642000000000001
+170183,Optimize the molecule Cc1noc(C(C)C)c1C(=O)NCc1cccnc1 to have a higher LogP value.,Cc1noc(C(C)C)c1C(=O)NCc1cccnc1,2.43142
+172534,Modify the molecule COc1ccc(-c2nsc(NC(=O)COc3cccc(C)c3)n2)cc1OC to decrease its LogP value.,COc1ccc(-c2nsc(NC(=O)COc3cccc(C)c3)n2)cc1OC,3.5482200000000015
+81353,Optimize the molecule O=C([O-])CNC(=O)c1ccc(NS(=O)(=O)c2ccc(N3CCCC3=O)cc2)cc1 to have a lower LogP value.,O=C([O-])CNC(=O)c1ccc(NS(=O)(=O)c2ccc(N3CCCC3=O)cc2)cc1,0.09390000000000098
+58697,Please modify the molecule CCCCNC(=O)[C@H]1CCCN(C(=O)c2ccc(NC(C)=O)cc2)C1 to decrease its LogP value.,CCCCNC(=O)[C@H]1CCCN(C(=O)c2ccc(NC(C)=O)cc2)C1,2.4135
+138885,Modify the molecule CCNc1nc(N(CC)n2cnnc2)nc(NC(C)(C)C)[nH+]1 to increase its LogP value.,CCNc1nc(N(CC)n2cnnc2)nc(NC(C)(C)C)[nH+]1,0.8139999999999996
+95359,Please modify the molecule COc1cc(C(=O)/C=C/c2ccc([N+](=O)[O-])cc2)ccc1OC(F)F to increase its LogP value.,COc1cc(C(=O)/C=C/c2ccc([N+](=O)[O-])cc2)ccc1OC(F)F,4.100900000000002
+33815,Please optimize the molecule CCCNC(=O)C(=O)NC[C@H]1OCCCN1S(=O)(=O)c1ccc(F)cc1C to have a higher LogP value.,CCCNC(=O)C(=O)NC[C@H]1OCCCN1S(=O)(=O)c1ccc(F)cc1C,0.5136200000000011
+221936,Modify the molecule Cc1cccc(C)c1OCC(=O)Nc1sccc1C#N to decrease its LogP value.,Cc1cccc(C)c1OCC(=O)Nc1sccc1C#N,3.2541200000000012
+89459,Modify the molecule CC(C)[C@@H](NC(=O)Nc1ccc([S@@](C)=O)cc1)c1ccccc1 to increase its LogP value.,CC(C)[C@@H](NC(=O)Nc1ccc([S@@](C)=O)cc1)c1ccccc1,3.942800000000002
+234000,Please optimize the molecule CCCCN1C[C@@H](C(=O)Nc2ccc(C(=O)NCC)cc2)CC1=O to have a lower LogP value.,CCCCN1C[C@@H](C(=O)Nc2ccc(C(=O)NCC)cc2)CC1=O,2.0233999999999996
+57681,Modify the molecule Nc1ccc(C(=O)Nc2ccccc2SC(F)F)cc1[N+](=O)[O-] to have a lower LogP value.,Nc1ccc(C(=O)Nc2ccccc2SC(F)F)cc1[N+](=O)[O-],3.7440000000000015
+229979,Please modify the molecule Cc1nn(CC(=O)OC[C@@H]2CN(CC(C)C)CCO2)c(=O)c2ccccc12 to increase its LogP value.,Cc1nn(CC(=O)OC[C@@H]2CN(CC(C)C)CCO2)c(=O)c2ccccc12,1.6049200000000001
+176458,Modify the molecule Cc1nn(-c2nc3c(c(=O)n(Cc4ccc(Cl)c(Cl)c4)c(=O)n3C)n2C)c(C)c1C to decrease its LogP value.,Cc1nn(-c2nc3c(c(=O)n(Cc4ccc(Cl)c(Cl)c4)c(=O)n3C)n2C)c(C)c1C,2.8997600000000014
+153671,Optimize the molecule Fc1ccc([C@@H](C[NH2+]Cc2ccsc2)N2CCOCC2)cc1 to have a higher LogP value.,Fc1ccc([C@@H](C[NH2+]Cc2ccsc2)N2CCOCC2)cc1,2.0241
+86027,Please optimize the molecule COc1ccc(-c2cc(-c3ccccc3)[nH]c(=O)n2)cc1OC to have a higher LogP value.,COc1ccc(-c2cc(-c3ccccc3)[nH]c(=O)n2)cc1OC,3.121100000000001
+3207,Modify the molecule COCCn1c2ccccc2n2c(=O)n(CC(=O)N(C)C)nc12 to have a lower LogP value.,COCCn1c2ccccc2n2c(=O)n(CC(=O)N(C)C)nc12,0.18530000000000024
+11219,Modify the molecule C[C@@H](CNC(=O)[C@]1(C)CC1(Cl)Cl)c1nc(-c2ccccc2)no1 to have a higher LogP value.,C[C@@H](CNC(=O)[C@]1(C)CC1(Cl)Cl)c1nc(-c2ccccc2)no1,3.5402000000000013
+125089,Modify the molecule CCC(=O)N(C)c1ccccc1C(=O)NCc1cccc(C#N)c1 to increase its LogP value.,CCC(=O)N(C)c1ccccc1C(=O)NCc1cccc(C#N)c1,2.861080000000001
+45747,Please optimize the molecule Cc1nc(CN(C)[C@H](C[NH3+])c2cccc(C3CC3)c2)cs1 to have a higher LogP value.,Cc1nc(CN(C)[C@H](C[NH3+])c2cccc(C3CC3)c2)cs1,2.743920000000001
+33655,Modify the molecule CN[C@@H]1C(=O)Nc2cc(S[C@@H]3CCC[C@@H](C)C3)c(Cl)cc21 to decrease its LogP value.,CN[C@@H]1C(=O)Nc2cc(S[C@@H]3CCC[C@@H](C)C3)c(Cl)cc21,4.223400000000003
+164324,Please modify the molecule O=c1cc(NCc2ccc3c(c2)OCCO3)cnn1Cc1ccccc1 to decrease its LogP value.,O=c1cc(NCc2ccc3c(c2)OCCO3)cnn1Cc1ccccc1,2.674900000000001
+220845,Optimize the molecule COc1ccc2cc(-c3ccc(C(=O)Nc4ccc5[nH]ccc5c4)cc3)c(=O)oc2c1 to have a higher LogP value.,COc1ccc2cc(-c3ccc(C(=O)Nc4ccc5[nH]ccc5c4)cc3)c(=O)oc2c1,5.202200000000003
+204050,Please optimize the molecule O=C1[C@@H]2ON(c3ccccc3)[C@@H](c3cccs3)[C@H]2C(=O)N1c1ccccc1 to have a lower LogP value.,O=C1[C@@H]2ON(c3ccccc3)[C@@H](c3cccs3)[C@H]2C(=O)N1c1ccccc1,3.7992000000000026
+33668,Modify the molecule Cc1cc(C2C[C@@H]3CC[C@H](C2)N3C(=O)c2ccc[nH]c2=O)ccc1F to have a higher LogP value.,Cc1cc(C2C[C@@H]3CC[C@H](C2)N3C(=O)c2ccc[nH]c2=O)ccc1F,3.3732200000000017
+6434,Please modify the molecule CNC(=O)NC(=O)Nc1cc(C)ccc1Cl to increase its LogP value.,CNC(=O)NC(=O)Nc1cc(C)ccc1Cl,2.10932
+141657,Please optimize the molecule CC(C)(C)Oc1cc(CNC(=O)N2CCC(n3cccn3)CC2)ccn1 to have a higher LogP value.,CC(C)(C)Oc1cc(CNC(=O)N2CCC(n3cccn3)CC2)ccn1,3.0021000000000013
+131750,Modify the molecule CCC[NH+]1CCN(C(=O)CN2CC[C@@]3(CCC2=O)NC(=O)c2ccccc2N3)CC1 to have a higher LogP value.,CCC[NH+]1CCN(C(=O)CN2CC[C@@]3(CCC2=O)NC(=O)c2ccccc2N3)CC1,-0.31219999999999515
+20326,Please modify the molecule COC(=O)c1cc(-c2ccccc2)nc2nc(NC(C)=O)sc12 to decrease its LogP value.,COC(=O)c1cc(-c2ccccc2)nc2nc(NC(C)=O)sc12,3.103300000000001
+186182,Modify the molecule COc1ccc2c(c1)[C@H]([NH3+])[C@@H](Sc1ccc(Cl)cn1)C2 to decrease its LogP value.,COc1ccc2c(c1)[C@H]([NH3+])[C@@H](Sc1ccc(Cl)cn1)C2,2.7436000000000007
+34518,Optimize the molecule [NH3+][C@@H]1CCN(C(=O)OCc2ccccc2)C[C@@H]1F to have a higher LogP value.,[NH3+][C@@H]1CCN(C(=O)OCc2ccccc2)C[C@@H]1F,0.9774999999999998
+180371,Modify the molecule CC[C@@H](Oc1ccc(/C=C2\SC(=S)N(NC(=O)c3ccccc3O)C2=O)cc1)C(=O)[O-] to have a lower LogP value.,CC[C@@H](Oc1ccc(/C=C2\SC(=S)N(NC(=O)c3ccccc3O)C2=O)cc1)C(=O)[O-],1.8456999999999988
+177157,Modify the molecule NC(=O)CC[NH+]1[C@@H](C(=O)[O-])CC[C@@H]2CCCC[C@H]21 to increase its LogP value.,NC(=O)CC[NH+]1[C@@H](C(=O)[O-])CC[C@@H]2CCCC[C@H]21,-1.7821999999999956
+69432,Modify the molecule Cn1nc2n(c1=O)-c1ccccc1SC2 to decrease its LogP value.,Cn1nc2n(c1=O)-c1ccccc1SC2,1.1767
+227147,Optimize the molecule O=c1[nH]c(=O)n(-c2cccc(Cl)c2)c2c1CN(Cc1cccnc1)CN2 to have a lower LogP value.,O=c1[nH]c(=O)n(-c2cccc(Cl)c2)c2c1CN(Cc1cccnc1)CN2,1.9593999999999996
+217234,Please optimize the molecule Cn1cc(C(=O)N2CCOCC2)cc(NC(=O)CCCc2ccccc2)c1=O to have a lower LogP value.,Cn1cc(C(=O)N2CCOCC2)cc(NC(=O)CCCc2ccccc2)c1=O,1.8190999999999995
+181863,Please optimize the molecule CCc1c(C)nc2cc(C3CCOCC3)nn2c1NCCC[NH+]1CCCCC1 to have a lower LogP value.,CCc1c(C)nc2cc(C3CCOCC3)nn2c1NCCC[NH+]1CCCCC1,2.3649199999999997
+70593,Modify the molecule C=CCO[C@H]1C[C@H]2C[C@@H]1[C@H]1CC=C[C@@H]12 to have a lower LogP value.,C=CCO[C@H]1C[C@H]2C[C@@H]1[C@H]1CC=C[C@@H]12,2.7897000000000007
+64681,Optimize the molecule COc1cccc(CC(=O)N2CCC([NH3+])CC2)c1 to have a higher LogP value.,COc1cccc(CC(=O)N2CCC([NH3+])CC2)c1,0.47060000000000046
+189699,Modify the molecule Cc1cc(Br)cc(C(=O)[O-])c1Br to decrease its LogP value.,Cc1cc(Br)cc(C(=O)[O-])c1Br,1.8835199999999996
+48873,Modify the molecule CCOCC/C([O-])=N/S(=O)(=O)c1ccccc1 to decrease its LogP value.,CCOCC/C([O-])=N/S(=O)(=O)c1ccccc1,0.5606999999999998
+1062,Please modify the molecule O=C1C[C@H](c2ccccc2C(F)(F)F)[C@H]2C(=O)N=C(c3ccccc3)N=C2N1 to decrease its LogP value.,O=C1C[C@H](c2ccccc2C(F)(F)F)[C@H]2C(=O)N=C(c3ccccc3)N=C2N1,3.3106000000000018
+87991,Please modify the molecule O=c1c2ccccc2c(=O)c2sc3c(=O)c4ccccc4c(=O)c3sc12 to increase its LogP value.,O=c1c2ccccc2c(=O)c2sc3c(=O)c4ccccc4c(=O)c3sc12,3.301000000000001
+222927,Optimize the molecule Cc1c(Cl)cccc1NC(=O)c1cc(C2CC2)nc2c1cnn2C(C)C to have a lower LogP value.,Cc1c(Cl)cccc1NC(=O)c1cc(C2CC2)nc2c1cnn2C(C)C,5.103720000000004
+109104,Modify the molecule O=C(CNC(=O)Nc1ccn(Cc2ccccc2)n1)NC1CC1 to increase its LogP value.,O=C(CNC(=O)Nc1ccn(Cc2ccccc2)n1)NC1CC1,1.3314999999999997
+138084,Optimize the molecule Cc1ncccc1NC(=O)N[C@H](c1ccccc1)C(C)(C)C to have a higher LogP value.,Cc1ncccc1NC(=O)N[C@H](c1ccccc1)C(C)(C)C,4.2989200000000025
+50554,Please optimize the molecule CC(C)(C)OC(=O)N1CCC(C(=O)NC2=NCCS2)CC1 to have a higher LogP value.,CC(C)(C)OC(=O)N1CCC(C(=O)NC2=NCCS2)CC1,1.8524999999999998
+102211,Please modify the molecule O=C(Cc1ccc2c(c1)CCCC2)Nc1ccc(S(=O)(=O)Nc2ncccn2)cc1 to increase its LogP value.,O=C(Cc1ccc2c(c1)CCCC2)Nc1ccc(S(=O)(=O)Nc2ncccn2)cc1,3.3374000000000015
+32877,Modify the molecule [NH3+]CC1CN([C@H]2CCOC3(CCSCC3)C2)C1 to increase its LogP value.,[NH3+]CC1CN([C@H]2CCOC3(CCSCC3)C2)C1,0.6048999999999998
+74500,Modify the molecule Cc1cc2nnc(SCCC(=O)Nc3ccccc3F)n2c(C)n1 to have a higher LogP value.,Cc1cc2nnc(SCCC(=O)Nc3ccccc3F)n2c(C)n1,3.0011400000000013
+73940,Optimize the molecule O=C(COc1ccc(Br)cc1F)NCC(=O)Nc1ccc(F)c(F)c1 to have a lower LogP value.,O=C(COc1ccc(Br)cc1F)NCC(=O)Nc1ccc(F)c(F)c1,3.0001000000000007
+181345,Modify the molecule O=C(NCCOc1ccc(F)c(F)c1)N[C@@H]1CCc2c(O)cccc21 to increase its LogP value.,O=C(NCCOc1ccc(F)c(F)c1)N[C@@H]1CCc2c(O)cccc21,3.0359000000000016
+12208,Modify the molecule CC(C)CC1(CNC(=O)[C@@H](NC(N)=O)C(C)C)CCCC1 to decrease its LogP value.,CC(C)CC1(CNC(=O)[C@@H](NC(N)=O)C(C)C)CCCC1,2.4019999999999992
+64377,Optimize the molecule N#Cc1ccc([C@H]2Nc3ccccc3C(=O)N2Cc2ccc3c(c2)OCO3)cc1 to have a higher LogP value.,N#Cc1ccc([C@H]2Nc3ccccc3C(=O)N2Cc2ccc3c(c2)OCO3)cc1,4.053680000000003
+139783,Modify the molecule COc1ccc(NC(=O)CSCC(C)C)cc1 to have a higher LogP value.,COc1ccc(NC(=O)CSCC(C)C)cc1,3.0229000000000017
+180698,Modify the molecule Cc1cc2ccccc2n1CC(=O)N1CCN(c2c(N)n(C)c(=O)n(C)c2=O)CC1 to increase its LogP value.,Cc1cc2ccccc2n1CC(=O)N1CCN(c2c(N)n(C)c(=O)n(C)c2=O)CC1,0.27812000000000126
+86046,Modify the molecule CC(=O)N[C@H](CC(=O)N[C@H](C)c1ccc(C)o1)c1cccs1 to have a lower LogP value.,CC(=O)N[C@H](CC(=O)N[C@H](C)c1ccc(C)o1)c1cccs1,3.0942200000000017
+146205,Please optimize the molecule CC[C@@H](C)NC(=O)c1ccc(NC(=O)N(C2CC2)[C@@H](C)c2ccco2)cc1 to have a lower LogP value.,CC[C@@H](C)NC(=O)c1ccc(NC(=O)N(C2CC2)[C@@H](C)c2ccco2)cc1,4.565400000000004
+175151,Please optimize the molecule CC(C)NC(=O)C(=O)NNC(=O)c1cn(-c2ccccc2)nc1-c1ccccc1 to have a higher LogP value.,CC(C)NC(=O)C(=O)NNC(=O)c1cn(-c2ccccc2)nc1-c1ccccc1,1.8249
+155666,Please modify the molecule Cc1cc(C)c(/C=N/NC(=O)COc2ccc([N+](=O)[O-])cc2)c(C)c1 to decrease its LogP value.,Cc1cc(C)c(/C=N/NC(=O)COc2ccc([N+](=O)[O-])cc2)c(C)c1,3.0491600000000014
+41650,Optimize the molecule Cc1cc(N2CCC([NH+](C)CCc3ccccc3Cl)CC2)nc(C)[nH+]1 to have a higher LogP value.,Cc1cc(N2CCC([NH+](C)CCc3ccccc3Cl)CC2)nc(C)[nH+]1,1.89214
+218117,Optimize the molecule COc1cccc(N2C(=O)c3ccc(C(=O)Nc4ccccc4[N+](=O)[O-])cc3C2=O)c1 to have a higher LogP value.,COc1cccc(N2C(=O)c3ccc(C(=O)Nc4ccccc4[N+](=O)[O-])cc3C2=O)c1,3.6563000000000017
+214811,Please modify the molecule Cc1ccc(NCC(=O)N/N=C/c2cc(Cl)ccc2O)cc1 to decrease its LogP value.,Cc1ccc(NCC(=O)N/N=C/c2cc(Cl)ccc2O)cc1,2.916220000000001
+22709,Please optimize the molecule CC[NH2+][C@H](Cc1nccn1C)C1CCCC1 to have a higher LogP value.,CC[NH2+][C@H](Cc1nccn1C)C1CCCC1,1.1046999999999998
+47716,Modify the molecule O=C(CCc1ccccc1O)NCCCn1cccn1 to decrease its LogP value.,O=C(CCc1ccccc1O)NCCCn1cccn1,1.7278
+137979,Please optimize the molecule Cc1cc(Br)cnc1N1CCC[C@H]1CCC[NH3+] to have a higher LogP value.,Cc1cc(Br)cnc1N1CCC[C@H]1CCC[NH3+],2.1434199999999994
+5179,Please modify the molecule C=CCOc1ccc(/C=C(\C#N)c2nc([O-])c3ccccc3n2)cc1OC to increase its LogP value.,C=CCOc1ccc(/C=C(\C#N)c2nc([O-])c3ccccc3n2)cc1OC,3.340980000000002
+37706,Please optimize the molecule CCCN(Cc1ccccc1O)C(=O)NCc1csc(CC)n1 to have a higher LogP value.,CCCN(Cc1ccccc1O)C(=O)NCc1csc(CC)n1,3.5329000000000015
+141038,Please optimize the molecule O=C(N/C=C(\[O-])N1CCc2ccccc21)Nc1cccc(C(F)(F)F)c1 to have a lower LogP value.,O=C(N/C=C(\[O-])N1CCc2ccccc21)Nc1cccc(C(F)(F)F)c1,3.048800000000001
+115625,Modify the molecule COc1cc([C@H](C)Nc2nccc(C(F)(F)F)n2)cc(OC)c1OC to increase its LogP value.,COc1cc([C@H](C)Nc2nccc(C(F)(F)F)n2)cc(OC)c1OC,3.694300000000002
+17606,Modify the molecule Cc1cc2oc(=O)cc(C[NH+]3CCN(CC(N)=O)CC3)c2cc1C to have a lower LogP value.,Cc1cc2oc(=O)cc(C[NH+]3CCN(CC(N)=O)CC3)c2cc1C,-0.4043599999999983
+30118,Please modify the molecule Cc1ccc2nc(COc3ccc(C(=O)N[C@@H](C)c4cccnc4)cc3)cn2c1 to decrease its LogP value.,Cc1ccc2nc(COc3ccc(C(=O)N[C@@H](C)c4cccnc4)cc3)cn2c1,4.107720000000002
+133277,Modify the molecule CCc1cccc(S(=O)(=O)N(CC)[C@H](C)c2cccnc2)c1 to decrease its LogP value.,CCc1cccc(S(=O)(=O)N(CC)[C@H](C)c2cccnc2)c1,3.4158000000000026
+218502,Optimize the molecule CC[NH+](C)Cc1cc2n(n1)CCN(C(=O)c1cnc3c(c1)ncn3C)C2 to have a higher LogP value.,CC[NH+](C)Cc1cc2n(n1)CCN(C(=O)c1cnc3c(c1)ncn3C)C2,-0.14459999999999873
+162593,Modify the molecule Cc1ccc(S(C)(=O)=O)cc1C(=O)N1c2ccccc2CC[C@@H]1C(C)C to decrease its LogP value.,Cc1ccc(S(C)(=O)=O)cc1C(=O)N1c2ccccc2CC[C@@H]1C(C)C,4.0161200000000035
+78430,Please modify the molecule CCOc1ccc(CNC(=O)CS(=O)(=O)NC)cc1C to decrease its LogP value.,CCOc1ccc(CNC(=O)CS(=O)(=O)NC)cc1C,0.5591200000000001
+193342,Modify the molecule COc1ccc(OC(=O)c2ccc3c(c2)NC(=O)CCN3C)cc1 to have a higher LogP value.,COc1ccc(OC(=O)c2ccc3c(c2)NC(=O)CCN3C)cc1,2.692800000000001
+200148,Please optimize the molecule O=C(Nc1ccc2c(c1)CCC2)C(=O)NC1CC[NH+](C[C@H]2CCOC2)CC1 to have a lower LogP value.,O=C(Nc1ccc2c(c1)CCC2)C(=O)NC1CC[NH+](C[C@H]2CCOC2)CC1,0.31380000000000097
+204570,Please optimize the molecule CCc1nn(C)c(OC)c1CNc1c(C#N)c(=O)n(C)c(=O)n1C to have a lower LogP value.,CCc1nn(C)c(OC)c1CNc1c(C#N)c(=O)n(C)c(=O)n1C,-0.1277199999999996
+65323,Please optimize the molecule CCCOCC[C@@]1(O)C[C@@H]1C to have a higher LogP value.,CCCOCC[C@@]1(O)C[C@@H]1C,1.5739999999999998
+25310,Please modify the molecule COc1ccccc1[C@@H](NC(=O)CCc1ccccc1C)c1noc(C)n1 to decrease its LogP value.,COc1ccccc1[C@@H](NC(=O)CCc1ccccc1C)c1noc(C)n1,3.5334400000000024
+235214,Optimize the molecule C[C@H]1CCN(C(=O)c2cc(C#N)cs2)c2cc(Cl)ccc2S1 to have a lower LogP value.,C[C@H]1CCN(C(=O)c2cc(C#N)cs2)c2cc(Cl)ccc2S1,4.804280000000003
+71385,Modify the molecule CS[C@H]1CCC[C@@H](NC(=O)CCC(=O)c2ccc(F)c(F)c2)C1 to have a higher LogP value.,CS[C@H]1CCC[C@@H](NC(=O)CCC(=O)c2ccc(F)c(F)c2)C1,3.7181000000000024
+97326,Please modify the molecule Cc1c([C@@H]2C[C@@H]2C[NH2+]C(C)C)cnn1C to decrease its LogP value.,Cc1c([C@@H]2C[C@@H]2C[NH2+]C(C)C)cnn1C,0.8038199999999995
+153453,Modify the molecule Cc1csc(SCc2cc(=O)oc3cc4c(cc23)CCC4)n1 to decrease its LogP value.,Cc1csc(SCc2cc(=O)oc3cc4c(cc23)CCC4)n1,4.338920000000003
+80203,Please modify the molecule C[C@@H]1CN(CCC(=O)c2cc(F)cc(F)c2)CC(C)(C)O1 to increase its LogP value.,C[C@@H]1CN(CCC(=O)c2cc(F)cc(F)c2)CC(C)(C)O1,3.036900000000002
+187970,Please modify the molecule C=C(C)CNC(=O)c1noc2c1CCc1ccc(OC)cc1-2 to decrease its LogP value.,C=C(C)CNC(=O)c1noc2c1CCc1ccc(OC)cc1-2,2.7547000000000015
+18230,Modify the molecule O=C(CC1CCN(C(=O)N[C@H]2CCC[C@@H](C3CC3)C2)CC1)N1CCCC1 to have a higher LogP value.,O=C(CC1CCN(C(=O)N[C@H]2CCC[C@@H](C3CC3)C2)CC1)N1CCCC1,3.389300000000002
+15385,Please modify the molecule CC[C@](C)(CCO)NC(=O)Nc1ccc2c(c1)COC2 to decrease its LogP value.,CC[C@](C)(CCO)NC(=O)Nc1ccc2c(c1)COC2,2.3894
+158629,Please modify the molecule Cc1ccc(N2CC[C@H](/C([O-])=N/S(=O)(=O)CCCF)C2=O)cc1C to decrease its LogP value.,Cc1ccc(N2CC[C@H](/C([O-])=N/S(=O)(=O)CCCF)C2=O)cc1C,1.1045399999999996
+119959,Please optimize the molecule CSCc1cc(F)ccc1CN[C@H](C(=O)NC(N)=O)c1ccccc1 to have a higher LogP value.,CSCc1cc(F)ccc1CN[C@H](C(=O)NC(N)=O)c1ccccc1,2.714500000000001
+168097,Optimize the molecule C[C@H]1SCCN(C(=O)c2c[nH]c3ccccc3c2=O)[C@@H]1C to have a lower LogP value.,C[C@H]1SCCN(C(=O)c2c[nH]c3ccccc3c2=O)[C@@H]1C,2.4941000000000004
+186701,Modify the molecule COCCNC(=O)c1ccc(C[NH+]2CCCC2)cc1 to have a higher LogP value.,COCCNC(=O)c1ccc(C[NH+]2CCCC2)cc1,0.24150000000000138
+108233,Please optimize the molecule C[C@@H](c1ccccc1)N(C)C(=O)NCc1cc[nH+]c(N2CCCC2)c1 to have a lower LogP value.,C[C@@H](c1ccccc1)N(C)C(=O)NCc1cc[nH+]c(N2CCCC2)c1,3.0035000000000016
+59251,Modify the molecule CCOC(=O)c1c(NC(=O)c2nnn(-c3ccc(C)cc3)c2C)sc2c1CC[C@@H](C)C2 to have a lower LogP value.,CCOC(=O)c1c(NC(=O)c2nnn(-c3ccc(C)cc3)c2C)sc2c1CC[C@@H](C)C2,4.499440000000004
+54828,Optimize the molecule COC(=O)c1ccc2[nH]c3c(c2c1)CN(C(=O)N[C@@H](C)c1ccccc1)CC3 to have a lower LogP value.,COC(=O)c1ccc2[nH]c3c(c2c1)CN(C(=O)N[C@@H](C)c1ccccc1)CC3,3.783400000000002
+132234,Optimize the molecule CC(C)[C@@H](C#N)N1CCN(C(=O)C[NH+](C)Cc2ccc(Cl)nc2)CC1 to have a lower LogP value.,CC(C)[C@@H](C#N)N1CCN(C(=O)C[NH+](C)Cc2ccc(Cl)nc2)CC1,0.4420800000000018
+228566,Please modify the molecule Cc1ccc(-n2ccnc2SCC(=O)N2CCC[C@H](C(N)=O)C2)cc1C to increase its LogP value.,Cc1ccc(-n2ccnc2SCC(=O)N2CCC[C@H](C(N)=O)C2)cc1C,2.3051399999999997
+158473,Modify the molecule O=C(OC[C@@H]1[C@H](CO)C1(Cl)Cl)c1ccccc1F to have a lower LogP value.,O=C(OC[C@@H]1[C@H](CO)C1(Cl)Cl)c1ccccc1F,2.3947000000000003
+70379,Optimize the molecule Cc1ccc(C(=O)N[C@H]2CCCc3c2cnn3C)c(F)c1 to have a lower LogP value.,Cc1ccc(C(=O)N[C@H]2CCCc3c2cnn3C)c(F)c1,2.675020000000001
+201791,Modify the molecule Cc1ccc([C@@H](C)NC(=O)CN(C)c2ccccc2[N+](=O)[O-])o1 to decrease its LogP value.,Cc1ccc([C@@H](C)NC(=O)CN(C)c2ccccc2[N+](=O)[O-])o1,2.809820000000001
+35339,Please optimize the molecule COC(=O)[C@H]1CCCC[C@@H]1NC(=O)c1c(Cl)c2ccccc2n1C to have a lower LogP value.,COC(=O)[C@H]1CCCC[C@@H]1NC(=O)c1c(Cl)c2ccccc2n1C,3.2933000000000012
+155084,Optimize the molecule CCOC(=O)c1ccc2c(c1)[C@H]1C=CC[C@@H]1[C@H](c1cccc(F)c1)N2 to have a lower LogP value.,CCOC(=O)c1ccc2c(c1)[C@H]1C=CC[C@@H]1[C@H](c1cccc(F)c1)N2,4.8289000000000035
+2982,Please optimize the molecule COCCOc1ncccc1NC(=O)N(C)Cc1ccccn1 to have a lower LogP value.,COCCOc1ncccc1NC(=O)N(C)Cc1ccccn1,2.1657
+136471,Please optimize the molecule COc1ccc([C@H]2[C@@H](CO)CCC[NH+]2C)cc1 to have a higher LogP value.,COc1ccc([C@H]2[C@@H](CO)CCC[NH+]2C)cc1,0.6532999999999998
+103994,Please modify the molecule COC[C@@H]1CN(Cc2nc3cc([N+](=O)[O-])ccc3o2)CCO1 to decrease its LogP value.,COC[C@@H]1CN(Cc2nc3cc([N+](=O)[O-])ccc3o2)CCO1,1.5832
+63069,Modify the molecule O=C(NCc1ncc[nH]1)c1c(O)cccc1Cl to have a higher LogP value.,O=C(NCc1ncc[nH]1)c1c(O)cccc1Cl,1.6986999999999999
+137625,Please optimize the molecule Cc1cccc(C(=O)Nc2ccccc2C(=O)OCc2cc([N+](=O)[O-])cc3c2OCOC3)c1 to have a higher LogP value.,Cc1cccc(C(=O)Nc2ccccc2C(=O)OCc2cc([N+](=O)[O-])cc3c2OCOC3)c1,4.379020000000002
+126557,Please optimize the molecule CCN(Cc1cccc(C)n1)S(=O)(=O)CCCl to have a lower LogP value.,CCN(Cc1cccc(C)n1)S(=O)(=O)CCCl,1.7805199999999999
+123002,Optimize the molecule CCCN[C@@H]1CCOC[C@@H]1[NH+]1CCC(C)(C)C1 to have a lower LogP value.,CCCN[C@@H]1CCOC[C@@H]1[NH+]1CCC(C)(C)C1,0.4583000000000015
+206391,Modify the molecule Cc1nc(CC(=O)N[C@@H](c2ccccc2)c2nnc(N)s2)cs1 to have a lower LogP value.,Cc1nc(CC(=O)N[C@@H](c2ccccc2)c2nnc(N)s2)cs1,2.33352
+148110,Please optimize the molecule CCOC(=O)c1cnn([C@@H]2CCCN(C(=O)N[C@@H](C)C(C)C)C2)c1 to have a lower LogP value.,CCOC(=O)c1cnn([C@@H]2CCCN(C(=O)N[C@@H](C)C(C)C)C2)c1,2.4508
+145833,Optimize the molecule Cc1cc(-c2nnc(-c3ccccc3Br)o2)ccc1[N+](=O)[O-] to have a lower LogP value.,Cc1cc(-c2nnc(-c3ccccc3Br)o2)ccc1[N+](=O)[O-],4.382720000000003
+71441,Modify the molecule CCSc1ccc([C@@H](C)NC(=O)C(=O)Nc2cncc(C)c2)cc1 to increase its LogP value.,CCSc1ccc([C@@H](C)NC(=O)C(=O)Nc2cncc(C)c2)cc1,3.3179200000000018
+122455,Please modify the molecule C[C@H](CCCO)[NH2+]Cc1nnc(-c2ccccc2)o1 to increase its LogP value.,C[C@H](CCCO)[NH2+]Cc1nnc(-c2ccccc2)o1,0.9610000000000001
+224706,Modify the molecule C[NH+]1CCC[C@@H]1C(=O)N1CCNCC1 to decrease its LogP value.,C[NH+]1CCC[C@@H]1C(=O)N1CCNCC1,-1.9046999999999967
+71436,Modify the molecule Cc1cc(S(N)(=O)=O)cc(C(=O)N[C@@H](CO)c2ccccc2F)c1C to decrease its LogP value.,Cc1cc(S(N)(=O)=O)cc(C(=O)N[C@@H](CO)c2ccccc2F)c1C,1.55334
+67457,Optimize the molecule CC(C)[NH+](CC(C)(C)CCC#N)C1CCC1 to have a higher LogP value.,CC(C)[NH+](CC(C)(C)CCC#N)C1CCC1,2.1621799999999993
+144291,Optimize the molecule CC(=O)Nc1ccc(N2C[C@H](C(=O)Nc3cc(C)ccn3)CC2=O)cc1 to have a higher LogP value.,CC(=O)Nc1ccc(N2C[C@H](C(=O)Nc3cc(C)ccn3)CC2=O)cc1,2.34002
+129648,Please optimize the molecule Cc1ccc(S(=O)(=O)[N-]c2cccc(Cl)c2F)cc1C to have a higher LogP value.,Cc1ccc(S(=O)(=O)[N-]c2cccc(Cl)c2F)cc1C,4.490040000000003
+78569,Please modify the molecule Cc1ccc(CNC(=S)Nc2ccc(Cl)cc2)cc1 to increase its LogP value.,Cc1ccc(CNC(=S)Nc2ccc(Cl)cc2)cc1,4.135020000000003
+62198,Modify the molecule N#Cc1ccccc1N[C@H]1c2ccccc2C(=O)N1Cc1ccccc1Cl to have a higher LogP value.,N#Cc1ccccc1N[C@H]1c2ccccc2C(=O)N1Cc1ccccc1Cl,4.978380000000002
+188322,Modify the molecule Cc1nn(C)c2ncc(NC(=O)C(=O)N(C)Cc3ccccc3F)cc12 to decrease its LogP value.,Cc1nn(C)c2ncc(NC(=O)C(=O)N(C)Cc3ccccc3F)cc12,2.0129199999999994
+233617,Optimize the molecule CC[C@@H](C)c1ccccc1OCC(=O)N1CCC[C@H]([NH+]2CCCC2)C1 to have a higher LogP value.,CC[C@@H](C)c1ccccc1OCC(=O)N1CCC[C@H]([NH+]2CCCC2)C1,2.2485999999999997
+232673,Please modify the molecule CN(C(=O)[O-])c1ccc2c(c1)CCN2 to increase its LogP value.,CN(C(=O)[O-])c1ccc2c(c1)CCN2,0.4341
+73899,Please modify the molecule CCOC[C@@H]1CC[NH+](CC(=O)Nc2c(C)cc(C)cc2C)C1 to decrease its LogP value.,CCOC[C@@H]1CC[NH+](CC(=O)Nc2c(C)cc(C)cc2C)C1,1.4916600000000002
+148838,Modify the molecule Cc1c(C(=O)N2CCc3c(sc(N)c3C#N)C2)cnn1CCC(C)C to have a higher LogP value.,Cc1c(C(=O)N2CCc3c(sc(N)c3C#N)C2)cnn1CCC(C)C,2.951500000000001
+226282,Please optimize the molecule O=C1CC[NH2+][C@H](c2ccccc2)C1 to have a lower LogP value.,O=C1CC[NH2+][C@H](c2ccccc2)C1,0.6539999999999999
+154695,Please modify the molecule C[C@@H]1CCCC[C@@H]1OCC[C@@H]1CCC[C@]1([NH3+])CO to increase its LogP value.,C[C@@H]1CCCC[C@@H]1OCC[C@@H]1CCC[C@]1([NH3+])CO,1.7449
+29298,Modify the molecule C[C@H]1CCC[C@@H](NC(=O)C(=O)Nc2ccc3c(c2)OC2(CCCC2)O3)C1 to have a lower LogP value.,C[C@H]1CCC[C@@H](NC(=O)C(=O)Nc2ccc3c(c2)OC2(CCCC2)O3)C1,3.361500000000002
+149317,Optimize the molecule CC(C)(C)c1noc(CCC(=O)N[C@@H]2CCC[C@@H](S(C)(=O)=O)C2)n1 to have a higher LogP value.,CC(C)(C)c1noc(CCC(=O)N[C@@H]2CCC[C@@H](S(C)(=O)=O)C2)n1,1.7717
+113831,Please optimize the molecule CN1CC[C@]2(CCC1=O)CN(Cc1ccc(C3CCCC3)s1)CC[NH+]2C to have a lower LogP value.,CN1CC[C@]2(CCC1=O)CN(Cc1ccc(C3CCCC3)s1)CC[NH+]2C,2.1170999999999998
+222037,Please optimize the molecule Cc1cc(Sc2nc(NC(C)C)nc(NC(C)C)n2)nc(Cl)n1 to have a lower LogP value.,Cc1cc(Sc2nc(NC(C)C)nc(NC(C)C)n2)nc(Cl)n1,3.4152200000000015
+128040,Optimize the molecule O=C(/C=C/c1ccccc1)C1=C(O)C(=O)N(c2ccccc2)[C@@H]1c1ccccc1F to have a higher LogP value.,O=C(/C=C/c1ccccc1)C1=C(O)C(=O)N(c2ccccc2)[C@@H]1c1ccccc1F,5.008200000000004
+93427,Modify the molecule Cc1cc(C)c(NC(=O)c2cccc(OCCC(C)C)c2)c(C)c1 to increase its LogP value.,Cc1cc(C)c(NC(=O)c2cccc(OCCC(C)C)c2)c(C)c1,5.2890600000000045
+61909,Modify the molecule Cc1nn(-c2ccccc2)c(N2CCCC2)c1/C=N/NC(=O)CNc1ccccc1 to increase its LogP value.,Cc1nn(-c2ccccc2)c(N2CCCC2)c1/C=N/NC(=O)CNc1ccccc1,3.3431200000000008
+168828,Modify the molecule NC(=O)NC(=O)OCCC[NH+]1CC[C@H](c2ccc(F)cc2)C1 to decrease its LogP value.,NC(=O)NC(=O)OCCC[NH+]1CC[C@H](c2ccc(F)cc2)C1,0.39290000000000025
+73394,Optimize the molecule CN(CCS(C)(=O)=O)c1n[nH]c(=S)n1C1CCCCC1 to have a higher LogP value.,CN(CCS(C)(=O)=O)c1n[nH]c(=S)n1C1CCCCC1,1.9266899999999998
+123318,Optimize the molecule COC1CCN(c2ccc(C(F)(F)F)cc2C(N)=[NH2+])CC1 to have a higher LogP value.,COC1CCN(c2ccc(C(F)(F)F)cc2C(N)=[NH2+])CC1,0.7850000000000001
+60588,Modify the molecule CCc1ccc(C(=O)N[C@H](C(=O)[O-])[C@H](C)CC)o1 to decrease its LogP value.,CCc1ccc(C(=O)N[C@H](C(=O)[O-])[C@H](C)CC)o1,0.7363999999999997
+24522,Modify the molecule CCc1cnc(C[NH+](C)Cc2c(CC)nn(C)c2CC)s1 to decrease its LogP value.,CCc1cnc(C[NH+](C)Cc2c(CC)nn(C)c2CC)s1,1.7786999999999997
+184920,Please optimize the molecule CC[C@H](C)CS(=O)(=O)c1cccc(Br)c1 to have a higher LogP value.,CC[C@H](C)CS(=O)(=O)c1cccc(Br)c1,3.268900000000002
+202763,Modify the molecule O=[N+]([O-])c1ccc([C@H]2OCN3COC[C@@H]23)cc1 to have a higher LogP value.,O=[N+]([O-])c1ccc([C@H]2OCN3COC[C@@H]23)cc1,1.2818999999999998
+179734,Optimize the molecule O=C(Nc1cc([N+](=O)[O-])ccc1O)c1cccc(Cl)c1F to have a lower LogP value.,O=C(Nc1cc([N+](=O)[O-])ccc1O)c1cccc(Cl)c1F,3.3452
+73141,Modify the molecule C#CCOc1cc(F)ccc1NCc1ccc(C(=O)OC)o1 to decrease its LogP value.,C#CCOc1cc(F)ccc1NCc1ccc(C(=O)OC)o1,2.8294000000000006
+210399,Optimize the molecule CC1(C)[C@H]2CC[C@]1(C)[C@](O)(CC(=O)[O-])C2 to have a lower LogP value.,CC1(C)[C@H]2CC[C@]1(C)[C@](O)(CC(=O)[O-])C2,0.7037
+42922,Modify the molecule Cc1cc(N2CCC[C@H](C(=O)[O-])C2)nc(C(C)C)[nH+]1 to have a lower LogP value.,Cc1cc(N2CCC[C@H](C(=O)[O-])C2)nc(C(C)C)[nH+]1,0.29382
+215517,Modify the molecule CCOc1cc(Nc2ccc(C#N)cn2)ccc1OC to have a higher LogP value.,CCOc1cc(Nc2ccc(C#N)cn2)ccc1OC,3.1041800000000013
+121837,Modify the molecule C[C@H](NC(=O)NCC1(O)CCCCCC1)C(=O)N1CCCC[C@@H]1C to have a higher LogP value.,C[C@H](NC(=O)NCC1(O)CCCCCC1)C(=O)N1CCCC[C@@H]1C,2.160399999999999
+181471,Please modify the molecule O=[N+]([O-])c1ccc(Nn2cccc2)cn1 to increase its LogP value.,O=[N+]([O-])c1ccc(Nn2cccc2)cn1,1.6664999999999999
+43931,Please optimize the molecule Cc1ccc2nc(N(C[C@@H]3CCCO3)C(=O)C3CCCC3)sc2c1 to have a higher LogP value.,Cc1ccc2nc(N(C[C@@H]3CCCO3)C(=O)C3CCCC3)sc2c1,4.306920000000003
+237384,Modify the molecule C[C@H](CC1CCCC1)[NH2+]C1CCN(S(=O)(=O)C2CC2)CC1 to increase its LogP value.,C[C@H](CC1CCCC1)[NH2+]C1CCN(S(=O)(=O)C2CC2)CC1,1.4752000000000007
+213409,Modify the molecule O=C(NCc1ccc(C(=O)N2CCCC2)cc1)[C@@H](O)c1ccccc1 to have a higher LogP value.,O=C(NCc1ccc(C(=O)N2CCCC2)cc1)[C@@H](O)c1ccccc1,2.2724
+223661,Please modify the molecule Cc1cc2nc(CSc3nnc(/N=C(\[O-])c4cccs4)s3)cc(=O)n2o1 to increase its LogP value.,Cc1cc2nc(CSc3nnc(/N=C(\[O-])c4cccs4)s3)cc(=O)n2o1,2.23982
+212205,Modify the molecule CC[NH+](C[C@@H]1CCCC(C)(C)C1=O)C1CC1 to have a lower LogP value.,CC[NH+](C[C@@H]1CCCC(C)(C)C1=O)C1CC1,1.4489999999999992
+46497,Optimize the molecule O=C(Nc1cnc2ccccc2c1)c1sccc1-c1ccc(F)cc1 to have a higher LogP value.,O=C(Nc1cnc2ccccc2c1)c1sccc1-c1ccc(F)cc1,5.354700000000003
+66142,Please modify the molecule Cc1ccc(S(=O)(=O)N2CCN(C(=O)NCCc3cccc(Cl)c3)CC2)cc1 to increase its LogP value.,Cc1ccc(S(=O)(=O)N2CCN(C(=O)NCCc3cccc(Cl)c3)CC2)cc1,2.907020000000001
+194525,Modify the molecule O=C(NCCCNC(=O)C1CCC1)N[C@H]1CCc2ccccc21 to have a higher LogP value.,O=C(NCCCNC(=O)C1CCC1)N[C@H]1CCc2ccccc21,2.2794999999999996
+136214,Modify the molecule COCCn1c(SCc2ncc(C(C)(C)C)o2)nc2ccccc21 to increase its LogP value.,COCCn1c(SCc2ncc(C(C)(C)C)o2)nc2ccccc21,4.260500000000004
+167424,Modify the molecule COc1cc(C[NH3+])ccc1OCC(C)C to decrease its LogP value.,COc1cc(C[NH3+])ccc1OCC(C)C,1.4718999999999998
+82593,Modify the molecule COc1cc([C@@H](C)NC(=O)c2ccncc2F)ccc1OC(C)C to decrease its LogP value.,COc1cc([C@@H](C)NC(=O)c2ccncc2F)ccc1OC(C)C,3.507500000000002
+163581,Please modify the molecule Cc1ccc(-c2nc(C)c(C(=O)N(C)C3CC[NH+](C)CC3)s2)c(C)c1 to increase its LogP value.,Cc1ccc(-c2nc(C)c(C(=O)N(C)C3CC[NH+](C)CC3)s2)c(C)c1,2.4844600000000003
+163842,Please modify the molecule CN(C)S(=O)(=O)N1CC=C(c2c[nH]c3ccccc23)CC1 to decrease its LogP value.,CN(C)S(=O)(=O)N1CC=C(c2c[nH]c3ccccc23)CC1,2.0634
+199707,Modify the molecule O=C(NC[C@@H](c1ccco1)[NH+]1CCCC1)N[C@@H]1CCc2c(O)cccc21 to increase its LogP value.,O=C(NC[C@@H](c1ccco1)[NH+]1CCCC1)N[C@@H]1CCc2c(O)cccc21,1.691699999999999
+34104,Optimize the molecule COc1ccc(S(=O)(=O)NCC2CC[NH+](Cc3ccsc3)CC2)cc1F to have a higher LogP value.,COc1ccc(S(=O)(=O)NCC2CC[NH+](Cc3ccsc3)CC2)cc1F,1.6692
+241949,Please modify the molecule Cc1ccsc1CNC(=O)[C@@]1(C)COC[C@H]1[NH3+] to decrease its LogP value.,Cc1ccsc1CNC(=O)[C@@]1(C)COC[C@H]1[NH3+],0.3197200000000004
+42375,Modify the molecule COc1ccc(C(=O)N=c2c(C#N)cc3c(=O)n4cccc(C)c4nc3n2C(C)C)cc1OC to increase its LogP value.,COc1ccc(C(=O)N=c2c(C#N)cc3c(=O)n4cccc(C)c4nc3n2C(C)C)cc1OC,3.1685000000000016
+239257,Please optimize the molecule COC(OC)c1csc(N2CCCC2)n1 to have a higher LogP value.,COC(OC)c1csc(N2CCCC2)n1,2.0347
+141429,Optimize the molecule N#Cc1c([O-])nc(SCc2nc3ccccc3c(=O)[nH]2)nc1-c1ccccc1 to have a higher LogP value.,N#Cc1c([O-])nc(SCc2nc3ccccc3c(=O)[nH]2)nc1-c1ccccc1,2.617680000000001
+143414,Modify the molecule COC(=O)c1nn(C[C@@H](O)COc2cc(C)cc(C)c2)c2c1CCCC2 to increase its LogP value.,COC(=O)c1nn(C[C@@H](O)COc2cc(C)cc(C)c2)c2c1CCCC2,2.6052400000000002
+27842,Modify the molecule O=C([C@H]1CC[C@@H]2CCCC[C@H]2C1)N1CCC(O)(C(F)(F)F)CC1 to increase its LogP value.,O=C([C@H]1CC[C@@H]2CCCC[C@H]2C1)N1CCC(O)(C(F)(F)F)CC1,3.508700000000003
+156045,Modify the molecule Cc1cnn(C[C@H]2CCCCN2C(=O)c2cc3ccccc3[nH]2)c1 to decrease its LogP value.,Cc1cnn(C[C@H]2CCCCN2C(=O)c2cc3ccccc3[nH]2)c1,3.367720000000001
+95802,Please optimize the molecule CCn1c(SCC(N)=O)nc2scc(-c3ccc(Cl)cc3)c2c1=O to have a higher LogP value.,CCn1c(SCC(N)=O)nc2scc(-c3ccc(Cl)cc3)c2c1=O,3.375700000000001
+197319,Modify the molecule COc1cc2c(cc1C[NH2+]C[C@H]1CCc3nncn3C1)O[C@@H](C)C2 to increase its LogP value.,COc1cc2c(cc1C[NH2+]C[C@H]1CCc3nncn3C1)O[C@@H](C)C2,0.9360999999999995
+94625,Please optimize the molecule CCc1cc(=O)[nH]c(-c2ccc(NCCc3nc(C(C)(C)C)cs3)nc2)n1 to have a higher LogP value.,CCc1cc(=O)[nH]c(-c2ccc(NCCc3nc(C(C)(C)C)cs3)nc2)n1,3.802900000000003
+17674,Modify the molecule C[C@H](Oc1ccc(/C=N/c2ccc(Cl)cc2Cl)cc1)C(=O)[O-] to have a lower LogP value.,C[C@H](Oc1ccc(/C=N/c2ccc(Cl)cc2Cl)cc1)C(=O)[O-],3.2612000000000023
+100038,Please optimize the molecule O=C(N/N=C\c1cccnc1)c1ccc(COc2ccc(Cl)cc2)cc1 to have a higher LogP value.,O=C(N/N=C\c1cccnc1)c1ccc(COc2ccc(Cl)cc2)cc1,4.077900000000002
+193435,Optimize the molecule O=C([C@@H]1C[C@@H]1c1cc(Cl)cc(Cl)c1)N1CCOC[C@@H]1C1CC1 to have a lower LogP value.,O=C([C@@H]1C[C@@H]1c1cc(Cl)cc(Cl)c1)N1CCOC[C@@H]1C1CC1,3.734300000000003
+170565,Optimize the molecule CNC(=O)c1ccc(C[NH2+]C2CCCCCCC2)cc1 to have a higher LogP value.,CNC(=O)c1ccc(C[NH2+]C2CCCCCCC2)cc1,2.2224999999999993
+166392,Modify the molecule C[C@H]1CCC[C@@H](NC(=O)C[NH+](C)CC2CC[NH2+]CC2)[C@@H]1C to decrease its LogP value.,C[C@H]1CCC[C@@H](NC(=O)C[NH+](C)CC2CC[NH2+]CC2)[C@@H]1C,-0.5845999999999958
+115061,Modify the molecule Cc1cc(CN2CCN(C(=O)CCCOc3ccccc3C)CC2)no1 to decrease its LogP value.,Cc1cc(CN2CCN(C(=O)CCCOc3ccccc3C)CC2)no1,2.7948400000000015
+214038,Modify the molecule Clc1ccnc(CSc2nnc3n2CCCCC3)c1 to decrease its LogP value.,Clc1ccnc(CSc2nnc3n2CCCCC3)c1,3.345200000000001
+96007,Modify the molecule Cc1ccc(N(C)C(=O)[C@H]2CCO[C@@H]2C)c(C)c1 to decrease its LogP value.,Cc1ccc(N(C)C(=O)[C@H]2CCO[C@@H]2C)c(C)c1,2.6912400000000005
+16039,Modify the molecule C[C@H](Nc1ncnc(Sc2ccc(Cl)cc2)c1N)c1ccccc1 to increase its LogP value.,C[C@H](Nc1ncnc(Sc2ccc(Cl)cc2)c1N)c1ccccc1,5.036500000000003
+241865,Modify the molecule CCOc1ccccc1OCCN1CCc2sccc2C1 to decrease its LogP value.,CCOc1ccccc1OCCN1CCc2sccc2C1,3.5839000000000025
+33787,Please optimize the molecule CCCSc1nnc(NC(=O)[C@H](C)Oc2cc(C)c(Cl)c(C)c2)s1 to have a higher LogP value.,CCCSc1nnc(NC(=O)[C@H](C)Oc2cc(C)c(Cl)c(C)c2)s1,4.716440000000004
+139037,Optimize the molecule CC(C)(C(=O)c1cncc2ccccc12)N1CCOCC1 to have a lower LogP value.,CC(C)(C(=O)c1cncc2ccccc12)N1CCOCC1,2.5283000000000007
+31981,Please modify the molecule Cc1c(C(=O)N[C@H]2C=CCCC2)cnn1C(C)C to increase its LogP value.,Cc1c(C(=O)N[C@H]2C=CCCC2)cnn1C(C)C,2.610920000000001
+178953,Please optimize the molecule CC(C)[C@H](NCC(=O)Nc1ccc(Br)cc1)c1cccnc1 to have a lower LogP value.,CC(C)[C@H](NCC(=O)Nc1ccc(Br)cc1)c1cccnc1,3.7695000000000016
+138147,Modify the molecule [NH3+][C@H]1CCC[C@@H]1CC[S@@](=O)c1ccc2c(c1)CCC2 to have a higher LogP value.,[NH3+][C@H]1CCC[C@@H]1CC[S@@](=O)c1ccc2c(c1)CCC2,2.083599999999999
+95565,Please modify the molecule Clc1cc2c(c(CSc3nncn3CCc3ccccn3)c1)OCOC2 to increase its LogP value.,Clc1cc2c(c(CSc3nncn3CCc3ccccn3)c1)OCOC2,3.7280000000000033
+55045,Please modify the molecule CC(C)CC(=O)N1CCN(c2cccc[nH+]2)CC1 to increase its LogP value.,CC(C)CC(=O)N1CCN(c2cccc[nH+]2)CC1,1.1954
+143364,Please optimize the molecule CCc1ocnc1C(=O)Nc1ccn(-c2ccc(Cl)cc2Cl)n1 to have a higher LogP value.,CCc1ocnc1C(=O)Nc1ccn(-c2ccc(Cl)cc2Cl)n1,3.9818000000000024
+195511,Modify the molecule CCOC(=O)c1c(NC(=O)N/N=C\CC(C)C)sc2c1CCC2 to decrease its LogP value.,CCOC(=O)c1c(NC(=O)N/N=C\CC(C)C)sc2c1CCC2,3.566900000000002
+49578,Modify the molecule Cc1cc([NH+]2CCCC[C@@H]2C)cc(C(=O)[O-])c1N to increase its LogP value.,Cc1cc([NH+]2CCCC[C@@H]2C)cc(C(=O)[O-])c1N,0.029520000000000546
+154792,Please optimize the molecule O=C([O-])CCc1cc2n(n1)CCN(Cc1ccc3[nH]ccc3c1)C2 to have a higher LogP value.,O=C([O-])CCc1cc2n(n1)CCN(Cc1ccc3[nH]ccc3c1)C2,1.0626999999999993
+122533,Modify the molecule COc1ccccc1[C@@H]1CCCN1C(=O)C[NH+](C)[C@@H]1CCS(=O)(=O)C1 to increase its LogP value.,COc1ccccc1[C@@H]1CCCN1C(=O)C[NH+](C)[C@@H]1CCS(=O)(=O)C1,0.060500000000002
+208321,Please optimize the molecule O=C(c1ccccc1[N-]S(=O)(=O)c1ccccc1[N+](=O)[O-])N1CCCC1 to have a lower LogP value.,O=C(c1ccccc1[N-]S(=O)(=O)c1ccccc1[N+](=O)[O-])N1CCCC1,3.2249000000000017
+219303,Modify the molecule N#Cc1ccc(CNCC(=O)NCCc2ccccc2)cc1 to have a lower LogP value.,N#Cc1ccc(CNCC(=O)NCCc2ccccc2)cc1,2.0067799999999996
+244912,Modify the molecule CC(C)(C)[C@H](NCc1cc(=O)n2nccc2[nH]1)c1cccs1 to have a higher LogP value.,CC(C)(C)[C@H](NCc1cc(=O)n2nccc2[nH]1)c1cccs1,2.961100000000001
+136443,Modify the molecule CCn1ncc(C[NH2+]C(C)C)c1C(F)(F)F to have a lower LogP value.,CCn1ncc(C[NH2+]C(C)C)c1C(F)(F)F,1.3936000000000002
+204864,Please optimize the molecule Clc1cccc(-c2cc(Br)ccn2)n1 to have a higher LogP value.,Clc1cccc(-c2cc(Br)ccn2)n1,3.5595000000000017
+139382,Modify the molecule C[C@H]1CN(Cc2ccc(C[NH2+]Cc3c(F)cccc3Cl)cc2)C[C@@H](C)O1 to decrease its LogP value.,C[C@H]1CN(Cc2ccc(C[NH2+]Cc3c(F)cccc3Cl)cc2)C[C@@H](C)O1,3.3519000000000014
+44099,Modify the molecule CCOC1CCN(C(=O)C(=O)Nc2ccc3c(c2)C(=O)CCC3)CC1 to have a higher LogP value.,CCOC1CCN(C(=O)C(=O)Nc2ccc3c(c2)C(=O)CCC3)CC1,2.1715999999999998
+194015,Please modify the molecule O=C(Cc1ccc(F)c(F)c1)NCCN1CCOCC1 to increase its LogP value.,O=C(Cc1ccc(F)c(F)c1)NCCN1CCOCC1,0.9557
+74954,Please modify the molecule O=C(CCn1cccn1)N1CCSCC1 to decrease its LogP value.,O=C(CCn1cccn1)N1CCSCC1,0.8485999999999999
+695,Optimize the molecule Cc1ccccc1Nc1nc(N)nc(COc2ccc(F)c(Cl)c2)n1 to have a lower LogP value.,Cc1ccccc1Nc1nc(N)nc(COc2ccc(F)c(Cl)c2)n1,3.877320000000002
+25203,Optimize the molecule CC[NH+](CC)C1([C@@H](N)Cc2ccc(F)cc2F)CCCC1 to have a higher LogP value.,CC[NH+](CC)C1([C@@H](N)Cc2ccc(F)cc2F)CCCC1,2.0721000000000003
+26252,Please modify the molecule CCOC(=O)CN(c1ccccc1)S(=O)(=O)c1ccc(Cl)cc1 to decrease its LogP value.,CCOC(=O)CN(c1ccccc1)S(=O)(=O)c1ccc(Cl)cc1,3.0984000000000016
+67153,Modify the molecule CCOC(=O)[C@@H]1CCC[NH+](Cc2c(O)cc(C)c3c2O/C(=C\c2ccc(N(C)C)cc2)C3=O)C1 to decrease its LogP value.,CCOC(=O)[C@@H]1CCC[NH+](Cc2c(O)cc(C)c3c2O/C(=C\c2ccc(N(C)C)cc2)C3=O)C1,2.740820000000001
+111483,Please optimize the molecule O=C(Nc1ccccc1)C1CCN(C(=O)c2ccc(-c3nc4ccccc4s3)o2)CC1 to have a higher LogP value.,O=C(Nc1ccccc1)C1CCN(C(=O)c2ccc(-c3nc4ccccc4s3)o2)CC1,5.047200000000004
+196441,Please modify the molecule CCC(CC)[NH2+]CCc1nncn1C1CC1 to increase its LogP value.,CCC(CC)[NH2+]CCc1nncn1C1CC1,0.9074999999999995
+244287,Please optimize the molecule Cc1cc(C)n(-c2ccc(N3CCN(C(=O)c4ccc(F)cc4F)CC3)nn2)n1 to have a higher LogP value.,Cc1cc(C)n(-c2ccc(N3CCN(C(=O)c4ccc(F)cc4F)CC3)nn2)n1,2.5197400000000005
+100457,Modify the molecule C[C@]12CCC[C@@H]1[C@@H]1CC(=O)[C@H]3CC(=O)CC[C@]3(C)[C@@H]1CC2 to decrease its LogP value.,C[C@]12CCC[C@@H]1[C@@H]1CC(=O)[C@H]3CC(=O)CC[C@]3(C)[C@@H]1CC2,4.167300000000004
+188821,Modify the molecule Cc1ccc(C(=O)C[C@]2(O)C(=O)N(C)c3ccc(Br)cc32)c(C)c1 to have a lower LogP value.,Cc1ccc(C(=O)C[C@]2(O)C(=O)N(C)c3ccc(Br)cc32)c(C)c1,3.5029400000000024
+245882,Modify the molecule O[C@H]([C@H]1CCCc2cccnc21)[C@H]1CC=CCC1 to have a higher LogP value.,O[C@H]([C@H]1CCCc2cccnc21)[C@H]1CC=CCC1,3.218700000000002
+54266,Please modify the molecule CCCN/C(N)=[NH+]/CC[C@@H](C)SC to decrease its LogP value.,CCCN/C(N)=[NH+]/CC[C@@H](C)SC,-0.4770999999999981
+197423,Modify the molecule Cc1ccc(-n2ccn3c(SCC(=O)Nc4cccc(F)c4)nnc3c2=O)cc1C to increase its LogP value.,Cc1ccc(-n2ccn3c(SCC(=O)Nc4cccc(F)c4)nnc3c2=O)cc1C,3.3669400000000014
+3234,Please modify the molecule CN(C[C@@H]1CC[NH+](C)C1)C(=O)N[C@@H](Cc1ccccc1)C1CC1 to increase its LogP value.,CN(C[C@@H]1CC[NH+](C)C1)C(=O)N[C@@H](Cc1ccccc1)C1CC1,1.183700000000001
+129429,Modify the molecule Cn1c(CN2CCSCC2)cc(=O)c(O)c1CN1CCN(S(C)(=O)=O)CC1 to have a higher LogP value.,Cn1c(CN2CCSCC2)cc(=O)c(O)c1CN1CCN(S(C)(=O)=O)CC1,-0.28309999999999813
+178005,Modify the molecule Cc1ccc(CCNC(=O)C(=O)Nc2ccc(F)c(-n3nnnc3C)c2)c(C)c1 to have a higher LogP value.,Cc1ccc(CCNC(=O)C(=O)Nc2ccc(F)c(-n3nnnc3C)c2)c(C)c1,2.0240599999999995
+178265,Please modify the molecule O=C(NCC[NH+]1CCCCC1)NNc1ccccc1Cl to increase its LogP value.,O=C(NCC[NH+]1CCCCC1)NNc1ccccc1Cl,1.0349
+116731,Please optimize the molecule CS(=O)(=O)N1C[C@H]2C[NH2+]C[C@@]2(C(=O)N2CC=CC2)C1 to have a lower LogP value.,CS(=O)(=O)N1C[C@H]2C[NH2+]C[C@@]2(C(=O)N2CC=CC2)C1,-2.1603999999999957
+229081,Modify the molecule O=C(N[C@H]1C[C@@H]2CCCc3cccc1c32)N1CCN(CC(F)F)CC1 to have a higher LogP value.,O=C(N[C@H]1C[C@@H]2CCCc3cccc1c32)N1CCN(CC(F)F)CC1,3.143600000000002
+89440,Modify the molecule CCOC(=O)C1=C(Cn2cnc3ccccc3c2=O)NC(=O)N[C@H]1c1ccccc1 to have a lower LogP value.,CCOC(=O)C1=C(Cn2cnc3ccccc3c2=O)NC(=O)N[C@H]1c1ccccc1,2.2678000000000003
+35858,Please optimize the molecule CC1CCN(C(=O)NCC2(c3ccc(Cl)cc3)CC2)CC1 to have a lower LogP value.,CC1CCN(C(=O)NCC2(c3ccc(Cl)cc3)CC2)CC1,3.813100000000003
+48830,Optimize the molecule CC(C)OC(=O)[C@@H](C)CNC(=O)/C(C#N)=C\c1ccco1 to have a lower LogP value.,CC(C)OC(=O)[C@@H](C)CNC(=O)/C(C#N)=C\c1ccco1,1.89048
+94205,Modify the molecule Cc1ccc(S(=O)(=O)CCCOc2cc(C)n(C)n2)cc1 to have a lower LogP value.,Cc1ccc(S(=O)(=O)CCCOc2cc(C)n(C)n2)cc1,2.2797400000000003
+142958,Modify the molecule CC(C)SSC(=O)N1CCC[C@@H]1C(=O)[O-] to have a lower LogP value.,CC(C)SSC(=O)N1CCC[C@@H]1C(=O)[O-],1.1105
+204224,Please optimize the molecule C[C@H]1C[C@@H]1C(=O)NCC1(c2ccc(F)cc2F)CC1 to have a higher LogP value.,C[C@H]1C[C@@H]1C(=O)NCC1(c2ccc(F)cc2F)CC1,2.768600000000001
+217315,Please optimize the molecule CC[C@H]1CC[C@](CC(C)(C)O)(C(=O)[O-])C1 to have a higher LogP value.,CC[C@H]1CC[C@](CC(C)(C)O)(C(=O)[O-])C1,1.0937999999999999
+7840,Please optimize the molecule CC(=O)N1CCc2[nH]c3ccc(C(=O)N4CCCC4)cc3c2C1 to have a lower LogP value.,CC(=O)N1CCc2[nH]c3ccc(C(=O)N4CCCC4)cc3c2C1,2.3085000000000004
+201751,Optimize the molecule CCN(Cc1cccs1)C(=O)c1ccc(-n2cnc3ccccc32)cc1 to have a lower LogP value.,CCN(Cc1cccs1)C(=O)c1ccc(-n2cnc3ccccc32)cc1,4.749300000000003
+116082,Optimize the molecule N#CCN1CCN(c2ncnc3sc4c(c23)CCCC4)CC1 to have a lower LogP value.,N#CCN1CCN(c2ncnc3sc4c(c23)CCCC4)CC1,2.21568
+211915,Modify the molecule CN(Cc1ccccc1)c1[nH+]cccc1CNC(=O)c1ccncc1F to have a higher LogP value.,CN(Cc1ccccc1)c1[nH+]cccc1CNC(=O)c1ccncc1F,2.6012000000000004
+78403,Modify the molecule Cc1ccccc1NC(=O)N1C[C@H](C)Sc2ccccc21 to increase its LogP value.,Cc1ccccc1NC(=O)N1C[C@H](C)Sc2ccccc21,4.527720000000003
+82133,Modify the molecule CCO[C@@H]1CCCN(C(=O)c2c(C)cc(C)c([N+](=O)[O-])c2C)C1 to decrease its LogP value.,CCO[C@@H]1CCCN(C(=O)c2c(C)cc(C)c([N+](=O)[O-])c2C)C1,3.1611600000000015
+199306,Optimize the molecule Cc1cccc(C)c1OCCC[NH2+]C1(C(N)=O)CCCCC1 to have a lower LogP value.,Cc1cccc(C)c1OCCC[NH2+]C1(C(N)=O)CCCCC1,1.823939999999999
+207378,Please optimize the molecule COC(=O)C1=C(N)OC2=C(CC(=O)C(C)(C)C2)[C@@]12C(=O)Nc1ccccc12 to have a lower LogP value.,COC(=O)C1=C(N)OC2=C(CC(=O)C(C)(C)C2)[C@@]12C(=O)Nc1ccccc12,1.893199999999999
+244724,Modify the molecule Nc1cc2[nH]c(=O)[nH]c2cc1S(=O)(=O)[O-] to decrease its LogP value.,Nc1cc2[nH]c(=O)[nH]c2cc1S(=O)(=O)[O-],-0.6575000000000002
+128024,Please modify the molecule CCO[C@H](NC(=O)c1ccccc1)c1cccc2ccccc12 to increase its LogP value.,CCO[C@H](NC(=O)c1ccccc1)c1cccc2ccccc12,4.304900000000003
+190151,Please modify the molecule CCn1c(C)c(C(=O)NC2(C(N)=O)CCCC2)c2cc(OC)ccc21 to decrease its LogP value.,CCn1c(C)c(C(=O)NC2(C(N)=O)CCCC2)c2cc(OC)ccc21,2.50612
+15924,Modify the molecule COc1cc2c(cc1OC)[C@H](c1ccccc1)N(S(=O)(=O)c1ccc(F)cc1)CC2 to increase its LogP value.,COc1cc2c(cc1OC)[C@H](c1ccccc1)N(S(=O)(=O)c1ccc(F)cc1)CC2,4.179300000000003
+38517,Modify the molecule CCn1cc(NC(=O)c2c(F)ccc(N)c2F)ccc1=O to increase its LogP value.,CCn1cc(NC(=O)c2c(F)ccc(N)c2F)ccc1=O,1.9808999999999999
+174202,Optimize the molecule C[C@H]1CCCC[NH+]1CCCNC(=O)C(=O)NCC#N to have a higher LogP value.,C[C@H]1CCCC[NH+]1CCCNC(=O)C(=O)NCC#N,-1.4102199999999967
+18210,Please optimize the molecule COc1ccc(CCNC(=O)C2CN(S(C)(=O)=O)C2)cc1OC to have a higher LogP value.,COc1ccc(CCNC(=O)C2CN(S(C)(=O)=O)C2)cc1OC,0.25390000000000135
+233050,Optimize the molecule CC[NH+]1CCC[C@H]1CN(C)CC(N)=O to have a lower LogP value.,CC[NH+]1CCC[C@H]1CN(C)CC(N)=O,-1.5292999999999959
+106863,Please optimize the molecule C=CC[NH+](Cc1cc(C)cc(C)c1)[C@@H]1CCS(=O)(=O)C1 to have a higher LogP value.,C=CC[NH+](Cc1cc(C)cc(C)c1)[C@@H]1CCS(=O)(=O)C1,1.0614399999999995
+237801,Modify the molecule Nn1c(SCc2c(F)cccc2Cl)nnc1-c1ccc(Cl)cc1 to have a lower LogP value.,Nn1c(SCc2c(F)cccc2Cl)nnc1-c1ccc(Cl)cc1,4.397100000000002
+163492,Please optimize the molecule CCn1c(SCC(=O)Nc2cc(C)n[nH]2)nc2ccsc2c1=O to have a higher LogP value.,CCn1c(SCC(=O)Nc2cc(C)n[nH]2)nc2ccsc2c1=O,2.24022
+161923,Modify the molecule C[C@@H]1C[C@H]1c1ccc(CN(C)C(=O)[C@@H]2CC(=O)N(C3CCCC3)C2)o1 to have a higher LogP value.,C[C@@H]1C[C@H]1c1ccc(CN(C)C(=O)[C@@H]2CC(=O)N(C3CCCC3)C2)o1,3.1525000000000016
+146480,Modify the molecule CCc1nn(C)cc1CNC(=O)Nc1cc(F)cc(OC)c1 to have a higher LogP value.,CCc1nn(C)cc1CNC(=O)Nc1cc(F)cc(OC)c1,2.451900000000001
+165035,Modify the molecule O=C(CSc1nnc(-c2cccnc2)o1)N(C1CCCCC1)[C@@H]1CCS(=O)(=O)C1 to decrease its LogP value.,O=C(CSc1nnc(-c2cccnc2)o1)N(C1CCCCC1)[C@@H]1CCS(=O)(=O)C1,2.5721000000000007
+49433,Please optimize the molecule CC[C@H]1Oc2ccc(C)cc2N(CC(=O)NCCC[NH+]2C[C@@H](C)C[C@H](C)C2)C1=O to have a lower LogP value.,CC[C@H]1Oc2ccc(C)cc2N(CC(=O)NCCC[NH+]2C[C@@H](C)C[C@H](C)C2)C1=O,1.566120000000001
+23750,Optimize the molecule CCc1nn(C)cc1CNc1ccc(NC(C)=O)c(OC)c1 to have a lower LogP value.,CCc1nn(C)cc1CNc1ccc(NC(C)=O)c(OC)c1,2.5616000000000003
+245265,Optimize the molecule CC(=O)c1ccc(OCC(=O)Oc2ccc(C)cc2Br)cc1 to have a lower LogP value.,CC(=O)c1ccc(OCC(=O)Oc2ccc(C)cc2Br)cc1,3.9445200000000034
+3295,Modify the molecule Cc1c(C(=O)/C=C/c2cnn(C)c2)nnn1-c1ccccc1 to have a higher LogP value.,Cc1c(C(=O)/C=C/c2cnn(C)c2)nnn1-c1ccccc1,2.2053199999999995
+243284,Please optimize the molecule Cc1ccc(C)c(NC(=O)CS[C@H]2N=N[C@@H]([C@@H]([NH3+])CC3=c4ccccc4=[NH+]C3)O2)c1 to have a lower LogP value.,Cc1ccc(C)c(NC(=O)CS[C@H]2N=N[C@@H]([C@@H]([NH3+])CC3=c4ccccc4=[NH+]C3)O2)c1,-0.3674599999999979
+133554,Modify the molecule Br[C@H]1c2ccccc2CCC[C@H]1Cc1nccs1 to decrease its LogP value.,Br[C@H]1c2ccccc2CCC[C@H]1Cc1nccs1,4.774300000000003
+28225,Modify the molecule Cc1csc(CSCC(=O)N(C)[C@H]2CCCc3ccccc32)n1 to have a lower LogP value.,Cc1csc(CSCC(=O)N(C)[C@H]2CCCc3ccccc32)n1,4.220720000000004
+208048,Optimize the molecule CC(C)c1ocnc1C(=O)N(C)[C@@H](C)c1ccc([S@](C)=O)cc1 to have a higher LogP value.,CC(C)c1ocnc1C(=O)N(C)[C@@H](C)c1ccc([S@](C)=O)cc1,3.3686000000000025
+81393,Modify the molecule C[C@H]1[C@@H]([NH3+])CCN(Cc2ccccc2Cl)[C@@H]1C to increase its LogP value.,C[C@H]1[C@@H]([NH3+])CCN(Cc2ccccc2Cl)[C@@H]1C,2.1807999999999996
+184658,Optimize the molecule CCc1cccc(NC(=O)C(=O)N[C@@H](Cn2cncn2)c2ccccc2)c1 to have a higher LogP value.,CCc1cccc(NC(=O)C(=O)N[C@@H](Cn2cncn2)c2ccccc2)c1,2.3366999999999996
+234678,Modify the molecule C[C@@H](CCC(C)(C)C)NC(=O)NC[C@H]1CCC[NH+](C)C1 to have a higher LogP value.,C[C@@H](CCC(C)(C)C)NC(=O)NC[C@H]1CCC[NH+](C)C1,1.4251000000000016
+2715,Optimize the molecule C[C@@H](C[NH2+]Cc1cc[nH]c1)c1ccc(F)c(F)c1 to have a higher LogP value.,C[C@@H](C[NH2+]Cc1cc[nH]c1)c1ccc(F)c(F)c1,2.1599999999999993
+177106,Modify the molecule CCc1nnsc1C(=O)N1CCC[NH+](Cc2ccccc2C)CC1 to increase its LogP value.,CCc1nnsc1C(=O)N1CCC[NH+](Cc2ccccc2C)CC1,1.3399199999999998
+249376,Modify the molecule CC(C)C[NH+](C1CC1)[C@H]1CCC(C)(C)[C@@H]1O to have a lower LogP value.,CC(C)C[NH+](C1CC1)[C@H]1CCC(C)(C)[C@@H]1O,1.2391999999999994
+90210,Please modify the molecule Cc1nc(-c2cccnc2)sc1[C@H](C)[NH2+]CC1(C2CC2)CCC1 to decrease its LogP value.,Cc1nc(-c2cccnc2)sc1[C@H](C)[NH2+]CC1(C2CC2)CCC1,3.718220000000003
+225729,Please modify the molecule CCOC[C@H]1CCN(C(=O)C[C@H]2c3ccccc3C=CN2C(C)=O)C1 to increase its LogP value.,CCOC[C@H]1CCN(C(=O)C[C@H]2c3ccccc3C=CN2C(C)=O)C1,2.8356000000000012
+204644,Modify the molecule NC(=S)N1N=C(c2ccccc2Cl)C[C@H]1c1cccs1 to decrease its LogP value.,NC(=S)N1N=C(c2ccccc2Cl)C[C@H]1c1cccs1,3.7962000000000016
+163744,Please optimize the molecule C[C@H]1OCC[C@@H]1C(=O)OCc1ccc([N+](=O)[O-])cc1Br to have a higher LogP value.,C[C@H]1OCC[C@@H]1C(=O)OCc1ccc([N+](=O)[O-])cc1Br,2.8255000000000017
+72865,Modify the molecule CSc1cccc(NC(=O)CSc2cc(-c3ccccn3)nc(C)n2)c1 to increase its LogP value.,CSc1cccc(NC(=O)CSc2cc(-c3ccccn3)nc(C)n2)c1,4.299720000000003
+9715,Modify the molecule Cc1cnc2c(c1)nc(CCl)n2[C@@H]1CCCC[C@@H]1C to decrease its LogP value.,Cc1cnc2c(c1)nc(CCl)n2[C@@H]1CCCC[C@@H]1C,4.229720000000003
+28815,Modify the molecule CC(=O)N1CCN(c2cc(CC[C@H]3CCC[NH2+]3)ncn2)CC1 to have a lower LogP value.,CC(=O)N1CCN(c2cc(CC[C@H]3CCC[NH2+]3)ncn2)CC1,-0.19649999999999768
+109512,Modify the molecule CC[NH2+][C@H]1CCCC[C@@H](Cc2ccc(O)cc2)C1 to have a higher LogP value.,CC[NH2+][C@H]1CCCC[C@@H](Cc2ccc(O)cc2)C1,2.4669
+99613,Optimize the molecule O=C(Nc1nc2c(s1)CCC[C@@H]2C(=O)Nc1cc2ccccc2oc1=O)c1ccc(Cl)cc1 to have a higher LogP value.,O=C(Nc1nc2c(s1)CCC[C@@H]2C(=O)Nc1cc2ccccc2oc1=O)c1ccc(Cl)cc1,5.2138000000000035
+20766,Please modify the molecule Cc1cc([O-])nc(SCC(=O)N[C@H]2N=C3CCCC[C@@H]3S2)n1 to increase its LogP value.,Cc1cc([O-])nc(SCC(=O)N[C@H]2N=C3CCCC[C@@H]3S2)n1,1.4809199999999998
+33466,Modify the molecule COc1cccc(C(=O)O[C@@H](C)C(=O)NC(=O)NC2CC2)c1O to have a lower LogP value.,COc1cccc(C(=O)O[C@@H](C)C(=O)NC(=O)NC2CC2)c1O,0.9342999999999997
+230283,Please optimize the molecule Cc1ccccc1OCC(=O)N[C@@H]1C[C@H](C)N(c2ccccc2)C1 to have a lower LogP value.,Cc1ccccc1OCC(=O)N[C@@H]1C[C@H](C)N(c2ccccc2)C1,3.157420000000002
+205457,Please modify the molecule CCCCN(C)[C@]1(C[NH3+])CSCCC1(C)C to decrease its LogP value.,CCCCN(C)[C@]1(C[NH3+])CSCCC1(C)C,1.8620999999999996
+8116,Modify the molecule Cc1cccc(NC(=O)N[C@@H]2CCC[NH+](C)C2)c1Cl to increase its LogP value.,Cc1cccc(NC(=O)N[C@@H]2CCC[NH+](C)C2)c1Cl,1.4470200000000002
+156827,Modify the molecule Cc1nn(C)c(Cl)c1CNC[C@@H](c1ccc(F)cc1)N1CCOCC1 to have a higher LogP value.,Cc1nn(C)c(Cl)c1CNC[C@@H](c1ccc(F)cc1)N1CCOCC1,2.684120000000001
+63522,Please optimize the molecule O=C(Nc1ccccc1)C1CCN(C(=O)c2ccc(O)c(Cl)c2)CC1 to have a lower LogP value.,O=C(Nc1ccccc1)C1CCN(C(=O)c2ccc(O)c(Cl)c2)CC1,3.536500000000002
+62023,Please optimize the molecule C[C@@H]1C[C@@H](C)CN(c2cc(SCC(=O)Nc3ccccc3Br)ncn2)C1 to have a lower LogP value.,C[C@@H]1C[C@@H](C)CN(c2cc(SCC(=O)Nc3ccccc3Br)ncn2)C1,4.452200000000003
+217424,Please modify the molecule CC[C@H](C)NC(=O)[C@@H](C)NC(=O)N[C@@H]1C[C@@H]1c1ccccc1 to decrease its LogP value.,CC[C@H](C)NC(=O)[C@@H](C)NC(=O)N[C@@H]1C[C@@H]1c1ccccc1,2.1449
+54265,Modify the molecule CCOc1ccc([C@@H](C[NH3+])N2CCC(CC)(CC)C2)cc1 to have a lower LogP value.,CCOc1ccc([C@@H](C[NH3+])N2CCC(CC)(CC)C2)cc1,2.8804000000000007
+198333,Please modify the molecule CS(=O)(=O)N1CCC[C@H](CCc2cccc(C(F)(F)F)c2)C1 to decrease its LogP value.,CS(=O)(=O)N1CCC[C@H](CCc2cccc(C(F)(F)F)c2)C1,3.3096000000000023
+60757,Optimize the molecule O=C(Cn1nc(-c2ccccc2)ccc1=O)Nc1cccc2cnccc12 to have a lower LogP value.,O=C(Cn1nc(-c2ccccc2)ccc1=O)Nc1cccc2cnccc12,3.097200000000001
+117497,Modify the molecule CS(=O)(=O)N1CCCc2cc([C@@H](O)C[NH+]3CCC(C(F)(F)F)CC3)ccc21 to have a lower LogP value.,CS(=O)(=O)N1CCCc2cc([C@@H](O)C[NH+]3CCC(C(F)(F)F)CC3)ccc21,1.2893999999999997
+139835,Modify the molecule CO[C@@H]1C[C@@H](C(=O)[O-])N(C(=O)CSc2cccs2)C1 to have a lower LogP value.,CO[C@@H]1C[C@@H](C(=O)[O-])N(C(=O)CSc2cccs2)C1,0.2060000000000004
+215533,Please optimize the molecule CCOc1cccc(CC(=O)NCc2cn(C)nc2CC)c1 to have a higher LogP value.,CCOc1cccc(CC(=O)NCc2cn(C)nc2CC)c1,2.2401
+116876,Modify the molecule O=C(NNC(=O)Nc1cccc(F)c1)Nc1ccc(OC(F)F)cc1 to decrease its LogP value.,O=C(NNC(=O)Nc1cccc(F)c1)Nc1ccc(OC(F)F)cc1,3.285300000000001
+102902,Please optimize the molecule Cc1occc1-c1nnc(SCc2coc(-c3ccccc3)n2)n1C to have a lower LogP value.,Cc1occc1-c1nnc(SCc2coc(-c3ccccc3)n2)n1C,4.330820000000004
+82792,Optimize the molecule CCOc1ccccc1NC(=O)C[C@H]1C(=O)Nc2nc(-c3ccccc3)nn21 to have a higher LogP value.,CCOc1ccccc1NC(=O)C[C@H]1C(=O)Nc2nc(-c3ccccc3)nn21,2.865800000000001
+128705,Modify the molecule Cc1cccc(-c2cc(=O)[nH]c(Nc3cc(F)c(F)c(F)c3)n2)c1 to increase its LogP value.,Cc1cccc(-c2cc(=O)[nH]c(Nc3cc(F)c(F)c(F)c3)n2)c1,3.906220000000002
+121620,Optimize the molecule Cn1c(SCc2ccc3c(c2)OCO3)nc2c(sc(=S)n2-c2ccc(Cl)cc2)c1=O to have a lower LogP value.,Cn1c(SCc2ccc3c(c2)OCO3)nc2c(sc(=S)n2-c2ccc(Cl)cc2)c1=O,5.1895900000000035
+81472,Optimize the molecule NC(=O)CN1CCN(C(=O)[C@H]2CCCO[C@H]2c2ccccc2)CC1 to have a lower LogP value.,NC(=O)CN1CCN(C(=O)[C@H]2CCCO[C@H]2c2ccccc2)CC1,0.7838000000000005
+106429,Modify the molecule CC[C@@H](C)CN(CC)C(=O)[C@@H]1CC[C@H](C[NH3+])O1 to increase its LogP value.,CC[C@@H](C)CN(CC)C(=O)[C@@H]1CC[C@H](C[NH3+])O1,0.6705000000000014
+229964,Please modify the molecule Cc1ccc(C[NH+](C)[C@H]2CCC[C@@H]2S(C)(=O)=O)cc1F to increase its LogP value.,Cc1ccc(C[NH+](C)[C@H]2CCC[C@@H]2S(C)(=O)=O)cc1F,1.1145200000000002
+164634,Please modify the molecule CCc1onc(C)c1NC(=O)N1CCN([C@H](C)CC(=O)OC)CC1 to decrease its LogP value.,CCc1onc(C)c1NC(=O)N1CCN([C@H](C)CC(=O)OC)CC1,1.6465199999999998
+145875,Please modify the molecule CSCC[C@](C)(O)CNC(=O)Cc1ccccc1Cl to increase its LogP value.,CSCC[C@](C)(O)CNC(=O)Cc1ccccc1Cl,2.5028000000000006
+243261,Please modify the molecule Cc1cc(C(=O)NCC(=O)N(C)Cc2ccco2)nn1C to increase its LogP value.,Cc1cc(C(=O)NCC(=O)N(C)Cc2ccco2)nn1C,0.7099199999999994
+95996,Please optimize the molecule Cc1cc(C(=O)OCC(=O)N[C@H]2CCCC[C@H]2C)c(C)o1 to have a higher LogP value.,Cc1cc(C(=O)OCC(=O)N[C@H]2CCCC[C@H]2C)c(C)o1,2.748140000000001
+34568,Modify the molecule CCCn1c(SCC(=O)N(C)C2(C#N)CCCCC2)nc2ccccc2c1=O to decrease its LogP value.,CCCn1c(SCC(=O)N(C)C2(C#N)CCCCC2)nc2ccccc2c1=O,3.5834800000000024
+139771,Modify the molecule COc1ccc(F)c(NC(=O)CSc2nnnn2C2CC2)c1 to increase its LogP value.,COc1ccc(F)c(NC(=O)CSc2nnnn2C2CC2)c1,1.8864999999999998
+206794,Please optimize the molecule CC1=Nc2ncnn2C(=O)[C@@H]1CCC(=O)N[C@H](C)c1ccccc1 to have a lower LogP value.,CC1=Nc2ncnn2C(=O)[C@@H]1CCC(=O)N[C@H](C)c1ccccc1,2.2981000000000007
+168692,Modify the molecule CC[C@@H](NC(=O)N(C)C[C@H](O)C1CC1)c1ccc(C)c(F)c1 to increase its LogP value.,CC[C@@H](NC(=O)N(C)C[C@H](O)C1CC1)c1ccc(C)c(F)c1,2.9975200000000015
+213483,Please optimize the molecule CC(=O)Oc1ccc(/C=C2/N=C(c3cccc(Cl)c3Cl)OC2=O)cc1OC(C)=O to have a lower LogP value.,CC(=O)Oc1ccc(/C=C2/N=C(c3cccc(Cl)c3Cl)OC2=O)cc1OC(C)=O,4.188500000000002
+124059,Optimize the molecule CCCc1cc(NC(=O)NC(C)(C)c2ccc(F)c(F)c2)n(C)n1 to have a higher LogP value.,CCCc1cc(NC(=O)NC(C)(C)c2ccc(F)c(F)c2)n(C)n1,3.707600000000002
+153416,Modify the molecule CCOC(=O)[C@H]1C(=O)N(Cc2ccccc2)c2nc3ccccc3n2[C@@H]1c1ccccc1F to decrease its LogP value.,CCOC(=O)[C@H]1C(=O)N(Cc2ccccc2)c2nc3ccccc3n2[C@@H]1c1ccccc1F,4.4909000000000034
+120031,Please optimize the molecule CC(C)c1n[nH]c([C@H]2CN(C(=O)c3ccc(=O)n(C)n3)CCO2)n1 to have a higher LogP value.,CC(C)c1n[nH]c([C@H]2CN(C(=O)c3ccc(=O)n(C)n3)CCO2)n1,0.23549999999999982
+137325,Modify the molecule C[C@H](NC(=O)NCCOCC(F)(F)F)c1ccc(Cl)s1 to have a higher LogP value.,C[C@H](NC(=O)NCCOCC(F)(F)F)c1ccc(Cl)s1,3.340600000000001
+243076,Modify the molecule COc1cccc(N2CCN(c3ccc(C(C)=O)cc3[N+](=O)[O-])CC2)c1 to increase its LogP value.,COc1cccc(N2CCN(c3ccc(C(C)=O)cc3[N+](=O)[O-])CC2)c1,3.132600000000002
+127807,Modify the molecule COc1ccc(C)cc1NC(=O)c1nnn(-c2ccc(F)cc2)n1 to have a higher LogP value.,COc1ccc(C)cc1NC(=O)c1nnn(-c2ccc(F)cc2)n1,2.3707200000000004
+212132,Modify the molecule C[C@H](NC(=O)[C@H](C)N1C(=O)[C@H]2CCCC[C@@H]2C1=O)c1ccc(F)c(F)c1 to increase its LogP value.,C[C@H](NC(=O)[C@H](C)N1C(=O)[C@H]2CCCC[C@@H]2C1=O)c1ccc(F)c(F)c1,2.7057
+238845,Modify the molecule CNC(=O)[C@H]1CCCCN1C(=O)c1cccc(F)c1 to increase its LogP value.,CNC(=O)[C@H]1CCCCN1C(=O)c1cccc(F)c1,1.5663999999999991
+9826,Modify the molecule Cc1cc(C)cc(Oc2cc(N3C(=O)[C@H]4[C@@H]5CC[C@@H](O5)[C@@H]4C3=O)cc([N+](=O)[O-])c2)c1 to have a lower LogP value.,Cc1cc(C)cc(Oc2cc(N3C(=O)[C@H]4[C@@H]5CC[C@@H](O5)[C@@H]4C3=O)cc([N+](=O)[O-])c2)c1,3.670740000000002
+127159,Modify the molecule Cc1nc(-c2cccc(CNC(=O)c3ccc[n+]([O-])c3)c2)n[nH]1 to decrease its LogP value.,Cc1nc(-c2cccc(CNC(=O)c3ccc[n+]([O-])c3)c2)n[nH]1,1.3435199999999998
+100991,Modify the molecule O=C(CCN1C(=O)c2ccccc2C1=O)N1CCN(C(=O)[C@H]2CCS(=O)(=O)C2)CC1 to increase its LogP value.,O=C(CCN1C(=O)c2ccccc2C1=O)N1CCN(C(=O)[C@H]2CCS(=O)(=O)C2)CC1,-0.221799999999998
+183628,Please optimize the molecule O=C(CCSc1ncc(-c2ccc(F)cc2)o1)Nc1ccccc1F to have a lower LogP value.,O=C(CCSc1ncc(-c2ccc(F)cc2)o1)Nc1ccccc1F,4.740700000000003
+19946,Please optimize the molecule CCc1nsc(NCC(=O)NC(C)(C)C)n1 to have a higher LogP value.,CCc1nsc(NCC(=O)NC(C)(C)C)n1,1.4271
+10728,Optimize the molecule CCc1oc2ccccc2c1/C=C/C(=O)N(C)C1CC[NH+](C)CC1 to have a lower LogP value.,CCc1oc2ccccc2c1/C=C/C(=O)N(C)C1CC[NH+](C)CC1,2.1439000000000004
+245108,Modify the molecule Cc1n[nH]c2cc(NC(=O)[C@@H](C)NC(=O)C3CCCCC3)ccc12 to have a higher LogP value.,Cc1n[nH]c2cc(NC(=O)[C@@H](C)NC(=O)C3CCCCC3)ccc12,2.894820000000001
+60400,Optimize the molecule C[NH+]1CCN(c2ccc(NC(=O)C(C)(C)c3cccc(C#N)c3)cc2)CC1 to have a higher LogP value.,C[NH+]1CCN(c2ccc(NC(=O)C(C)(C)c3cccc(C#N)c3)cc2)CC1,1.80928
+142900,Please optimize the molecule CC[C@H](C)CN(CC)C(=O)[C@H]1CCC[C@H]([NH3+])[C@@H]1C to have a higher LogP value.,CC[C@H](C)CN(CC)C(=O)[C@H]1CCC[C@H]([NH3+])[C@@H]1C,1.9277
+38090,Modify the molecule CC[C@H]1C(=O)NCC[NH+]1CC(=O)Nc1cc(Cl)ccc1F to decrease its LogP value.,CC[C@H]1C(=O)NCC[NH+]1CC(=O)Nc1cc(Cl)ccc1F,0.21090000000000125
+187679,Modify the molecule CC[NH2+][C@@]1(C(N)=O)CCC[C@H](N(C)[C@@H]2CCS(=O)(=O)C2)C1 to increase its LogP value.,CC[NH2+][C@@]1(C(N)=O)CCC[C@H](N(C)[C@@H]2CCS(=O)(=O)C2)C1,-1.1446999999999965
+165308,Modify the molecule COc1ccc(/C=C/C(=O)Nc2cc(C)cc(C)c2)cc1S(=O)(=O)NC(C)C to decrease its LogP value.,COc1ccc(/C=C/C(=O)Nc2cc(C)cc(C)c2)cc1S(=O)(=O)NC(C)C,3.650640000000002
+123140,Please modify the molecule CCn1c(CNC(=O)c2c(C)cc(C)c([N+](=O)[O-])c2C)n[nH]c1=S to decrease its LogP value.,CCn1c(CNC(=O)c2c(C)cc(C)c([N+](=O)[O-])c2C)n[nH]c1=S,2.724050000000001
+179069,Modify the molecule C[C@H](NC(=O)CN1CC[NH+](C)C[C@@H]1C)c1ccc(Cl)cc1Cl to increase its LogP value.,C[C@H](NC(=O)CN1CC[NH+](C)C[C@@H]1C)c1ccc(Cl)cc1Cl,1.3894000000000009
+199008,Modify the molecule COc1cccc(Cn2cc(C(F)(F)F)ccc2=O)c1 to have a higher LogP value.,COc1cccc(Cn2cc(C(F)(F)F)ccc2=O)c1,2.9240000000000013
+16019,Modify the molecule C[C@@H](NS(=O)(=O)c1ccccc1C(F)(F)F)C(=O)NNC(=O)c1ccco1 to increase its LogP value.,C[C@@H](NS(=O)(=O)c1ccccc1C(F)(F)F)C(=O)NNC(=O)c1ccco1,1.4264000000000001
+112003,Please modify the molecule CC(=O)Nc1ccc(NC(=O)CCc2cnn(-c3ccccc3)c2)cc1 to increase its LogP value.,CC(=O)Nc1ccc(NC(=O)CCc2cnn(-c3ccccc3)c2)cc1,3.402000000000002
+221025,Modify the molecule CC(C)[NH2+]C[C@@H](Cc1cccc(Cl)c1)Cc1nccs1 to decrease its LogP value.,CC(C)[NH2+]C[C@@H](Cc1cccc(Cl)c1)Cc1nccs1,3.1697000000000015
+181692,Modify the molecule COc1cccc(N2CC[C@@H](CNC(=O)N3CCCC[C@@H]3C)C2)c1 to increase its LogP value.,COc1cccc(N2CC[C@@H](CNC(=O)N3CCCC[C@@H]3C)C2)c1,3.105500000000002
+213877,Modify the molecule COc1ccc(Br)cc1CNC(=O)c1cccc2cc[nH]c12 to have a lower LogP value.,COc1ccc(Br)cc1CNC(=O)c1cccc2cc[nH]c12,3.8690000000000015
+190062,Please optimize the molecule CC(C)(C)OC(=O)Nc1cccc(CC(=O)Nc2cccnc2Cl)c1 to have a higher LogP value.,CC(C)(C)OC(=O)Nc1cccc(CC(=O)Nc2cccnc2Cl)c1,4.263200000000003
+94557,Please modify the molecule Cc1nnnn1-c1ccc(F)c(NC(=O)c2cccc3c2OCO3)c1 to decrease its LogP value.,Cc1nnnn1-c1ccc(F)c(NC(=O)c2cccc3c2OCO3)c1,2.09082
+233836,Please optimize the molecule COc1ccc2c(CC(=O)Nc3cccc(S(=O)(=O)N4CCCC4)c3)coc2c1 to have a higher LogP value.,COc1ccc2c(CC(=O)Nc3cccc(S(=O)(=O)N4CCCC4)c3)coc2c1,3.4071000000000025
+112894,Optimize the molecule CC[C@@H](C)Oc1cccc(NC(=O)C[NH+](C)C)c1 to have a lower LogP value.,CC[C@@H](C)Oc1cccc(NC(=O)C[NH+](C)C)c1,0.9469000000000002
+157649,Modify the molecule CNC(=O)C1CC[NH+]([C@H](C)C(=O)Nc2cc(F)ccc2F)CC1 to decrease its LogP value.,CNC(=O)C1CC[NH+]([C@H](C)C(=O)Nc2cc(F)ccc2F)CC1,0.3327000000000009
+225024,Please modify the molecule Cc1ccc(-c2noc3ncnc(N4CCC(C(=O)NC(C)C)CC4)c23)cc1 to increase its LogP value.,Cc1ccc(-c2noc3ncnc(N4CCC(C(=O)NC(C)C)CC4)c23)cc1,3.334220000000002
+22381,Modify the molecule COc1ccc(N2C[C@@H](C(=O)Nc3cccc(C(C)=O)c3)CC2=O)cc1 to decrease its LogP value.,COc1ccc(N2C[C@@H](C(=O)Nc3cccc(C(C)=O)c3)CC2=O)cc1,2.889400000000001
+242935,Please modify the molecule CCCc1cc(C(=O)NCc2ccncc2)n(C)n1 to increase its LogP value.,CCCc1cc(C(=O)NCc2ccncc2)n(C)n1,1.6976
+94716,Please modify the molecule CO[C@@]1(C)C[C@H](N(C)C(=O)CCCn2cncn2)C1(C)C to increase its LogP value.,CO[C@@]1(C)C[C@H](N(C)C(=O)CCCn2cncn2)C1(C)C,1.720299999999999
+216419,Please modify the molecule O=C(NC[C@H](O)COc1ccc(F)cc1)c1cnc([C@H]2CCCO2)s1 to decrease its LogP value.,O=C(NC[C@H](O)COc1ccc(F)cc1)c1cnc([C@H]2CCCO2)s1,2.3034
+139464,Please optimize the molecule O=C(CCc1cc(Cl)no1)N1[C@H]2CC[C@@H]1Cn1c(nc3ccccc3c1=O)C2 to have a higher LogP value.,O=C(CCc1cc(Cl)no1)N1[C@H]2CC[C@@H]1Cn1c(nc3ccccc3c1=O)C2,2.5864000000000003
+150469,Please optimize the molecule Cc1ccc2ncc(C[NH+]3CCCC[C@@H]3c3cccn3C)n2c1 to have a higher LogP value.,Cc1ccc2ncc(C[NH+]3CCCC[C@@H]3c3cccn3C)n2c1,2.29132
+122078,Optimize the molecule CC(C)(C)Oc1cc(C(=O)N2CCO[C@@H](c3ccccc3Cl)C2)ccn1 to have a lower LogP value.,CC(C)(C)Oc1cc(C(=O)N2CCO[C@@H](c3ccccc3Cl)C2)ccn1,4.126000000000003
+46099,Please modify the molecule CN(C)S(=O)(=O)c1ccc(/C=C/C(=O)OCc2ccccc2)cc1 to decrease its LogP value.,CN(C)S(=O)(=O)c1ccc(/C=C/C(=O)OCc2ccccc2)cc1,2.693500000000001
+63154,Modify the molecule CC(=O)Nc1ccc2nc(NC(=O)C3(c4ccc(Br)cc4)CC3)sc2c1 to decrease its LogP value.,CC(=O)Nc1ccc2nc(NC(=O)C3(c4ccc(Br)cc4)CC3)sc2c1,4.687500000000003
+99129,Optimize the molecule CN(CCOc1ccccc1F)C(=O)CCC1CCCCC1 to have a lower LogP value.,CN(CCOc1ccccc1F)C(=O)CCC1CCCCC1,4.023400000000003
+58108,Modify the molecule Cc1cc(N2CCO[C@@H](c3ccc(F)cc3)C2)ncc1[N+](=O)[O-] to have a lower LogP value.,Cc1cc(N2CCO[C@@H](c3ccc(F)cc3)C2)ncc1[N+](=O)[O-],3.015220000000002
+165992,Please modify the molecule C=CCn1nc2c(C)c(C)nc(-c3cccnc3)n2c1=O to decrease its LogP value.,C=CCn1nc2c(C)c(C)nc(-c3cccnc3)n2c1=O,1.7558399999999996
+8312,Optimize the molecule O=C(OCC(=O)N1CCO[C@H]2CCCC[C@H]21)c1ccc(CO)cc1 to have a lower LogP value.,O=C(OCC(=O)N1CCO[C@H]2CCCC[C@H]21)c1ccc(CO)cc1,1.5056999999999992
+37312,Modify the molecule O=C(CCC(=O)Nc1ccccc1Cl)NNC(=O)C(F)(F)F to have a higher LogP value.,O=C(CCC(=O)Nc1ccccc1Cl)NNC(=O)C(F)(F)F,1.7683999999999997
+85020,Optimize the molecule C[C@H](C#N)Oc1ccc(C[NH+](C)CCC2CC2)cc1 to have a lower LogP value.,C[C@H](C#N)Oc1ccc(C[NH+](C)CCC2CC2)cc1,1.7922799999999994
+32051,Modify the molecule O=C(Cc1c(F)cccc1Cl)/N=C1/NCCS1 to decrease its LogP value.,O=C(Cc1c(F)cccc1Cl)/N=C1/NCCS1,2.2405999999999997
+88382,Optimize the molecule Cc1nc(N2CCN(Cc3c(C)nc4sc(C)cn34)CC2)c2cnn(C)c2n1 to have a lower LogP value.,Cc1nc(N2CCN(Cc3c(C)nc4sc(C)cn34)CC2)c2cnn(C)c2n1,2.31996
+55387,Optimize the molecule COCc1cccc(C(=O)Nc2cc(C(=O)N(C)C)ccc2C)c1 to have a higher LogP value.,COCc1cccc(C(=O)Nc2cc(C(=O)N(C)C)ccc2C)c1,3.0955200000000014
+106049,Optimize the molecule COc1ccc(NC(=O)N2CCNC(=O)C2)cc1Cc1ccccc1 to have a higher LogP value.,COc1ccc(NC(=O)N2CCNC(=O)C2)cc1Cc1ccccc1,2.2497
+25581,Modify the molecule O=C1c2ccccc2N[C@H](c2ccc(O)c([N+](=O)[O-])c2)N1c1ccncc1 to have a higher LogP value.,O=C1c2ccccc2N[C@H](c2ccc(O)c([N+](=O)[O-])c2)N1c1ccncc1,3.4665000000000017
+147985,Modify the molecule Cc1ccc(-n2nnc(-c3nsc(NC(=O)c4ccc(C(C)(C)C)cc4)n3)c2C)cc1 to have a higher LogP value.,Cc1ccc(-n2nnc(-c3nsc(NC(=O)c4ccc(C(C)(C)C)cc4)n3)c2C)cc1,4.952440000000004
+29924,Optimize the molecule Cc1csc([C@@H](C)NC(=O)CCCO)n1 to have a higher LogP value.,Cc1csc([C@@H](C)NC(=O)CCCO)n1,1.40122
+247106,Modify the molecule O=C([O-])[C@@H](Cc1ccccc1)[P@@](=O)([O-])C[NH+]1CCOCC1 to have a higher LogP value.,O=C([O-])[C@@H](Cc1ccccc1)[P@@](=O)([O-])C[NH+]1CCOCC1,-2.1413999999999964
+108131,Modify the molecule CN(C)[C@@H](C(=O)N1CCC(N2CCOC2=O)CC1)c1ccccc1F to have a higher LogP value.,CN(C)[C@@H](C(=O)N1CCC(N2CCOC2=O)CC1)c1ccccc1F,1.8715999999999995
+183815,Please optimize the molecule CCc1ccc(-c2nc(CC(=O)N(C)[C@@H](C)c3sc(C)nc3C)cs2)cc1 to have a higher LogP value.,CCc1ccc(-c2nc(CC(=O)N(C)[C@@H](C)c3sc(C)nc3C)cs2)cc1,5.207940000000005
+222945,Please optimize the molecule CCN1CCO[C@@H](CNc2cc(C(F)(F)F)ccc2Cl)C1 to have a higher LogP value.,CCN1CCO[C@@H](CNc2cc(C(F)(F)F)ccc2Cl)C1,3.4914000000000023
+183760,Optimize the molecule CCn1nc(C)c(NC(=O)N2CCO[C@H](c3ccccc3F)C2)c1C to have a lower LogP value.,CCn1nc(C)c(NC(=O)N2CCO[C@H](c3ccccc3F)C2)c1C,3.2643400000000025
+83644,Optimize the molecule Cc1noc(C)c1C[NH+]1C[C@@H]2CC[C@H](C1)N(C(=O)c1ccoc1)C2 to have a higher LogP value.,Cc1noc(C)c1C[NH+]1C[C@@H]2CC[C@H](C1)N(C(=O)c1ccoc1)C2,1.2039399999999993
+50969,Modify the molecule C[C@H](CC1CCCC1)C(=O)NCCc1nc2ccccc2s1 to decrease its LogP value.,C[C@H](CC1CCCC1)C(=O)NCCc1nc2ccccc2s1,4.171400000000003
+191407,Optimize the molecule Nc1nc(N2CC(=O)N(CCc3ccccc3)C(=O)C2)ncc1C(=O)NCc1ccccc1 to have a higher LogP value.,Nc1nc(N2CC(=O)N(CCc3ccccc3)C(=O)C2)ncc1C(=O)NCc1ccccc1,1.4066999999999987
+207869,Optimize the molecule COC(=O)CN1C(=O)c2ccccc2O[C@@H]1c1ccc(OC)cc1 to have a higher LogP value.,COC(=O)CN1C(=O)c2ccccc2O[C@@H]1c1ccc(OC)cc1,2.4016
+25812,Modify the molecule COc1ccc(Cc2noc([C@H]3CC[NH2+][C@H]3C)n2)cn1 to have a lower LogP value.,COc1ccc(Cc2noc([C@H]3CC[NH2+][C@H]3C)n2)cn1,0.5032
+84278,Modify the molecule C/C(=N/N=C1/NC(=O)[C@@H](CC(=O)Nc2ccccc2C)S1)c1ccc([N+](=O)[O-])cc1 to have a lower LogP value.,C/C(=N/N=C1/NC(=O)[C@@H](CC(=O)Nc2ccccc2C)S1)c1ccc([N+](=O)[O-])cc1,3.2436200000000017
+207691,Modify the molecule CN(CC1CC1)C(=O)[C@H]1CC(=O)N(C)[C@H]1c1cccnc1 to have a higher LogP value.,CN(CC1CC1)C(=O)[C@H]1CC(=O)N(C)[C@H]1c1cccnc1,1.4693999999999994
+134820,Please optimize the molecule O=C(Nc1ccc(Cl)cc1)c1ccc(-n2cccn2)c([N+](=O)[O-])c1 to have a lower LogP value.,O=C(Nc1ccc(Cl)cc1)c1ccc(-n2cccn2)c([N+](=O)[O-])c1,3.686200000000002
+153394,Please optimize the molecule C=CCNC(=O)NC(=O)[C@H](C)Nc1ccc(CC(=O)NC)cc1 to have a higher LogP value.,C=CCNC(=O)NC(=O)[C@H](C)Nc1ccc(CC(=O)NC)cc1,0.7873000000000001
+217731,Please modify the molecule N#Cc1csc(C(=O)Nc2ccc(O[C@@H]3CCOC3)cc2)c1 to increase its LogP value.,N#Cc1csc(C(=O)Nc2ccc(O[C@@H]3CCOC3)cc2)c1,3.0397800000000013
+109634,Modify the molecule CC(C)(C(=O)N1CC[NH+](C2CC2)CC1)c1cccc(C#N)c1 to decrease its LogP value.,CC(C)(C(=O)N1CC[NH+](C2CC2)CC1)c1cccc(C#N)c1,0.725380000000001
+84261,Modify the molecule Cc1ccc([C@@H]2CC(=O)C[C@H](c3ccc(C)cc3)[NH2+]2)cc1 to have a lower LogP value.,Cc1ccc([C@@H]2CC(=O)C[C@H](c3ccc(C)cc3)[NH2+]2)cc1,3.0121400000000005
+75148,Optimize the molecule C[C@@H](C[NH3+])CN1CC[NH+](Cc2cn3ccccc3n2)CC1 to have a higher LogP value.,C[C@@H](C[NH3+])CN1CC[NH+](Cc2cn3ccccc3n2)CC1,-1.0871999999999966
+106749,Optimize the molecule Cc1ccc(CC(=O)N(C)C2CCN(c3cccc(F)c3)CC2)cn1 to have a higher LogP value.,Cc1ccc(CC(=O)N(C)C2CCN(c3cccc(F)c3)CC2)cn1,3.1990200000000018
+68483,Please optimize the molecule O=C(NCC1CCCCC1)[C@@H]1CCCN1C(=O)c1cc2scnc2[nH]1 to have a lower LogP value.,O=C(NCC1CCCCC1)[C@@H]1CCCN1C(=O)c1cc2scnc2[nH]1,2.9255000000000004
+105728,Please optimize the molecule CCOC(=O)c1cccc(NC(=O)c2cc(-c3cccnc3)n(-c3ccccc3)n2)c1 to have a lower LogP value.,CCOC(=O)c1cccc(NC(=O)c2cc(-c3cccnc3)n(-c3ccccc3)n2)c1,4.363300000000002
+100360,Please optimize the molecule COc1ccc(C[NH2+][C@H](C)c2cccc3ccccc23)cc1O to have a higher LogP value.,COc1ccc(C[NH2+][C@H](C)c2cccc3ccccc23)cc1O,3.378600000000002
+186681,Modify the molecule CCc1ccccc1NC(=O)[C@@H]1CC(=O)NC2=NC(SC)=NC(=O)[C@@H]21 to have a lower LogP value.,CCc1ccccc1NC(=O)[C@@H]1CC(=O)NC2=NC(SC)=NC(=O)[C@@H]21,1.5974999999999997
+77877,Modify the molecule CSC[C@@H](C)NC(=O)[C@@H]1CCC(=O)N1Cc1ccc(C)cc1 to decrease its LogP value.,CSC[C@@H](C)NC(=O)[C@@H]1CCC(=O)N1Cc1ccc(C)cc1,2.35372
+108602,Modify the molecule C[C@@H](CC#N)N(C)c1c(F)c(F)nc(F)c1F to decrease its LogP value.,C[C@@H](CC#N)N(C)c1c(F)c(F)nc(F)c1F,2.37638
+22795,Modify the molecule CNS(=O)(=O)c1cccc(NC(=O)/C=C(/C)C(C)(C)C)c1 to have a higher LogP value.,CNS(=O)(=O)c1cccc(NC(=O)/C=C(/C)C(C)(C)C)c1,2.5256000000000007
+103912,Modify the molecule C[C@H](c1ccncc1)[NH+]1[C@H]2CC[C@@H]1CC(CC(=O)[O-])C2 to have a higher LogP value.,C[C@H](c1ccncc1)[NH+]1[C@H]2CC[C@@H]1CC(CC(=O)[O-])C2,0.10850000000000026
+153345,Please modify the molecule O=C1CC[C@H](NC(=O)CCSc2ccnc3cc(Cl)ccc23)CN1 to increase its LogP value.,O=C1CC[C@H](NC(=O)CCSc2ccnc3cc(Cl)ccc23)CN1,2.765200000000001
+64134,Modify the molecule CC(C)(C)[NH2+]Cc1ccn(Cc2cc(F)cc(Br)c2)n1 to increase its LogP value.,CC(C)(C)[NH2+]Cc1ccn(Cc2cc(F)cc(Br)c2)n1,2.6949000000000005
+208356,Optimize the molecule Cc1ccc(NC(=O)NC2CC[NH+](C)CC2)s1 to have a higher LogP value.,Cc1ccc(NC(=O)NC2CC[NH+](C)CC2)s1,0.8551199999999997
+35316,Modify the molecule COc1ccccc1CCN1Cc2cc(NC(=O)c3ccccc3OC)ccc2OCC1=O to have a higher LogP value.,COc1ccccc1CCN1Cc2cc(NC(=O)c3ccccc3OC)ccc2OCC1=O,3.919800000000002
+154605,Please modify the molecule CC(C)Cc1ccc(CNc2cnn(-c3ncccn3)c2)cc1 to increase its LogP value.,CC(C)Cc1ccc(CNc2cnn(-c3ncccn3)c2)cc1,3.472900000000002
+244409,Please optimize the molecule COc1ccc([C@H]2SCC(O)=Nc3n[nH]cc32)c(OC)c1 to have a lower LogP value.,COc1ccc([C@H]2SCC(O)=Nc3n[nH]cc32)c(OC)c1,2.8511000000000006
+208342,Optimize the molecule O=C(CN1C(=O)NC2(CCCCC2)C1=O)Nc1ccc(N2CCCC2)cc1 to have a higher LogP value.,O=C(CN1C(=O)NC2(CCCCC2)C1=O)Nc1ccc(N2CCCC2)cc1,2.4799999999999995
+55014,Modify the molecule CCN(CC#N)CCC(=O)NC1CCCCC1 to have a higher LogP value.,CCN(CC#N)CCC(=O)NC1CCCCC1,1.6708799999999995
+50267,Please modify the molecule CN(C[C@H](O)C1CC1)C(=O)CN(C)c1ccccc1[N+](=O)[O-] to decrease its LogP value.,CN(C[C@H](O)C1CC1)C(=O)CN(C)c1ccccc1[N+](=O)[O-],1.2602999999999993
+103464,Please optimize the molecule Cc1cc(NC(=O)N[C@@H]2[C@@H]3CCO[C@@H]3C2(C)C)c2ncccc2c1 to have a higher LogP value.,Cc1cc(NC(=O)N[C@@H]2[C@@H]3CCO[C@@H]3C2(C)C)c2ncccc2c1,3.478220000000002
+56243,Modify the molecule C[C@@H](C(=O)NCC(=O)N1CCc2ccccc2C1)c1cccs1 to have a higher LogP value.,C[C@@H](C(=O)NCC(=O)N1CCc2ccccc2C1)c1cccs1,2.5527000000000006
+88358,Optimize the molecule C[NH2+]Cc1ccc(-c2ccc(C)c(C)c2)c(C)c1 to have a higher LogP value.,C[NH2+]Cc1ccc(-c2ccc(C)c(C)c2)c(C)c1,2.9720600000000017
+60274,Please modify the molecule CC(=O)c1cnc2nc(-c3ccncc3)nn2c1/C=C/N(C)C to increase its LogP value.,CC(=O)c1cnc2nc(-c3ccncc3)nn2c1/C=C/N(C)C,1.9212
+178337,Optimize the molecule COc1ccc(N2CCn3c2nn(CC(=O)Nc2ccc(F)cc2F)c(=O)c3=O)cc1 to have a lower LogP value.,COc1ccc(N2CCn3c2nn(CC(=O)Nc2ccc(F)cc2F)c(=O)c3=O)cc1,1.4821999999999997
+65443,Please optimize the molecule COc1ccc([C@H]2C(C(=O)Nc3cc(OC)c(Cl)cc3OC)=C(C)Nc3nnnn32)cc1 to have a lower LogP value.,COc1ccc([C@H]2C(C(=O)Nc3cc(OC)c(Cl)cc3OC)=C(C)Nc3nnnn32)cc1,3.2799000000000005
+118088,Optimize the molecule C[C@@H](CNC(=O)c1ccc(-n2cncn2)c([N+](=O)[O-])c1)[NH+](C)C1CC1 to have a higher LogP value.,C[C@@H](CNC(=O)c1ccc(-n2cncn2)c([N+](=O)[O-])c1)[NH+](C)C1CC1,-0.029099999999999016
+77991,Modify the molecule CC(C)n1c([C@H]2CCCN(C(=O)Nc3ccc(C(F)(F)F)cc3)C2)nn(C)c1=O to decrease its LogP value.,CC(C)n1c([C@H]2CCCN(C(=O)Nc3ccc(C(F)(F)F)cc3)C2)nn(C)c1=O,3.5930000000000017
+10805,Please optimize the molecule Cc1ccc(C(=O)NCC(=O)N[C@@H](C)c2cccc(Cl)c2)cc1 to have a higher LogP value.,Cc1ccc(C(=O)NCC(=O)N[C@@H](C)c2cccc(Cl)c2)cc1,3.255620000000002
+147383,Modify the molecule Cc1cc(C(=O)CN2CCOC[C@H]2C#N)c(C)n1CC(F)(F)F to decrease its LogP value.,Cc1cc(C(=O)CN2CCOC[C@H]2C#N)c(C)n1CC(F)(F)F,2.0743199999999997
+163523,Please modify the molecule COc1ccc([C@@H]([NH2+]C[C@@H]2CC(=O)Nc3ccccc32)C(C)C)cc1 to increase its LogP value.,COc1ccc([C@@H]([NH2+]C[C@@H]2CC(=O)Nc3ccccc32)C(C)C)cc1,3.0817000000000014
+103224,Optimize the molecule CCC(=O)[C@H]1CCCN(C(=O)C[C@@]2(c3ccccc3F)CC(=O)N(C3CCCC3)C2=O)C1 to have a lower LogP value.,CCC(=O)[C@H]1CCCN(C(=O)C[C@@]2(c3ccccc3F)CC(=O)N(C3CCCC3)C2=O)C1,3.3728000000000025
+887,Please optimize the molecule O=C1CC[C@@H](NC(=O)COc2ccc(Cl)c(Cl)c2)CN1 to have a lower LogP value.,O=C1CC[C@@H](NC(=O)COc2ccc(Cl)c(Cl)c2)CN1,1.7669999999999997
+207365,Please modify the molecule Cn1cnc(S(=O)(=O)NC2(c3ccc(Cl)cc3)CCOCC2)c1 to decrease its LogP value.,Cn1cnc(S(=O)(=O)NC2(c3ccc(Cl)cc3)CCOCC2)c1,2.0576999999999996
+196436,Optimize the molecule Cc1cc(C)n(-c2ccc(C(=O)NC[C@H]3CCCO3)cc2)n1 to have a higher LogP value.,Cc1cc(C)n(-c2ccc(C(=O)NC[C@H]3CCCO3)cc2)n1,2.39794
+205020,Optimize the molecule CCOc1ccc(S(=O)(=O)Nc2cccc(N3CCCCC3=O)c2)cc1F to have a higher LogP value.,CCOc1ccc(S(=O)(=O)Nc2cccc(N3CCCCC3=O)c2)cc1F,3.5421000000000022
+111851,Please modify the molecule CCC[C@](O)(c1ccccc1)c1cc(C)cc(F)c1 to increase its LogP value.,CCC[C@](O)(c1ccccc1)c1cc(C)cc(F)c1,4.170120000000003
+243557,Please modify the molecule C[C@@H](C1CC1)N(C)C(=O)c1csc(C#CCCO)c1 to increase its LogP value.,C[C@@H](C1CC1)N(C)C(=O)c1csc(C#CCCO)c1,2.352500000000001
+213196,Modify the molecule CCOc1ccccc1OCCOCCOc1ccc([N+](=O)[O-])cc1 to have a higher LogP value.,CCOc1ccccc1OCCOCCOc1ccc([N+](=O)[O-])cc1,3.467900000000002
+88486,Optimize the molecule Cc1nc([C@H](NC(=O)[C@H]2CSC(=O)N2)c2ccc(Cl)cc2)no1 to have a lower LogP value.,Cc1nc([C@H](NC(=O)[C@H]2CSC(=O)N2)c2ccc(Cl)cc2)no1,2.0620199999999995
+158796,Please optimize the molecule Cc1ccc(S(=O)(=O)N2CCN(C(=O)c3ccc(-c4nnco4)cc3)CC2)c(C)c1 to have a higher LogP value.,Cc1ccc(S(=O)(=O)N2CCN(C(=O)c3ccc(-c4nnco4)cc3)CC2)c(C)c1,2.500140000000001
+246191,Please optimize the molecule CCn1c(N2CCN(C(=O)c3ccc(F)cc3)CC2)nc2c(C)nn(C)c2c1=O to have a higher LogP value.,CCn1c(N2CCN(C(=O)c3ccc(F)cc3)CC2)nc2c(C)nn(C)c2c1=O,1.55982
+230091,Modify the molecule CCCC(=O)N1CCC[C@H]1C(=O)N[C@H](C)c1cc(OC)c(OC)cc1F to have a lower LogP value.,CCCC(=O)N1CCC[C@H]1C(=O)N[C@H](C)c1cc(OC)c(OC)cc1F,2.8112000000000013
+174656,Modify the molecule CC(C)[NH+]1C[C@H](C)[C@@H](NCc2ccc3c(c2)OCCCO3)C1 to increase its LogP value.,CC(C)[NH+]1C[C@H](C)[C@@H](NCc2ccc3c(c2)OCCCO3)C1,1.2491000000000005
+159866,Modify the molecule CC(C)(C)c1ccc(NC(=O)c2ccc(N3C(=O)CSCC3=O)cc2)cc1 to increase its LogP value.,CC(C)(C)c1ccc(NC(=O)c2ccc(N3C(=O)CSCC3=O)cc2)cc1,3.842800000000003
+24873,Please optimize the molecule Cc1cc(C(=O)N2CCC[C@@H]2[C@H]2CCC[C@@H]2O)ccc1F to have a higher LogP value.,Cc1cc(C(=O)N2CCC[C@@H]2[C@H]2CCC[C@@H]2O)ccc1F,2.899720000000001
+51629,Modify the molecule C[C@H]1CSC(SCc2coc(-c3ccc(F)cc3)n2)=N1 to have a higher LogP value.,C[C@H]1CSC(SCc2coc(-c3ccc(F)cc3)n2)=N1,4.205200000000003
+94669,Please optimize the molecule CC(C)NC(=O)N(C)C[C@@H]1CC(c2ccc(Cl)cc2)=NO1 to have a lower LogP value.,CC(C)NC(=O)N(C)C[C@@H]1CC(c2ccc(Cl)cc2)=NO1,2.8828000000000005
+115615,Please optimize the molecule Cn1cc([C@H](O)CNC(=O)Nc2ccc(F)cc2OCC(F)F)cn1 to have a higher LogP value.,Cn1cc([C@H](O)CNC(=O)Nc2ccc(F)cc2OCC(F)F)cn1,2.0582
+75955,Modify the molecule CC(C)CNC(=O)N1CCN(Cc2nc3cc(C(=O)NC(C)C)ccc3n2C)CC1 to decrease its LogP value.,CC(C)CNC(=O)N1CCN(Cc2nc3cc(C(=O)NC(C)C)ccc3n2C)CC1,2.194699999999999
+132465,Please optimize the molecule COc1ccc(-c2noc([C@H]3CCCN(S(=O)(=O)c4cccc(F)c4)C3)n2)cc1OC to have a higher LogP value.,COc1ccc(-c2noc([C@H]3CCCN(S(=O)(=O)c4cccc(F)c4)C3)n2)cc1OC,3.4612000000000025
+108247,Modify the molecule OCc1ccc(-c2nccn2C2CC[NH+](C[C@@H]3CCCO3)CC2)o1 to decrease its LogP value.,OCc1ccc(-c2nccn2C2CC[NH+](C[C@@H]3CCCO3)CC2)o1,1.0341999999999996
+140537,Please modify the molecule COC(=O)c1ccc(/C=N/NC(=O)c2nn(Cc3ccccc3)c(=O)c3ccccc23)cc1 to increase its LogP value.,COC(=O)c1ccc(/C=N/NC(=O)c2nn(Cc3ccccc3)c(=O)c3ccccc23)cc1,2.995300000000001
+5973,Modify the molecule NC(=O)c1ccc(C(=O)Oc2cc(F)cc(Br)c2)cn1 to increase its LogP value.,NC(=O)c1ccc(C(=O)Oc2cc(F)cc(Br)c2)cn1,2.3013000000000003
+7600,Modify the molecule O=C(OCc1ccccn1)c1ccc(COc2ccccc2Cl)o1 to have a lower LogP value.,O=C(OCc1ccccn1)c1ccc(COc2ccccc2Cl)o1,4.264000000000003
+163762,Modify the molecule COc1ccc(N2C[C@H](C(=O)Nc3n[nH]c(-c4ccccc4OC)n3)CC2=O)cc1 to have a lower LogP value.,COc1ccc(N2C[C@H](C(=O)Nc3n[nH]c(-c4ccccc4OC)n3)CC2=O)cc1,2.4805
+245477,Modify the molecule CS[C@H](C)c1cccc(NC(=O)[C@H]2CSC(=O)N2)c1 to have a higher LogP value.,CS[C@H](C)c1cccc(NC(=O)[C@H]2CSC(=O)N2)c1,2.8741000000000003
+114694,Optimize the molecule COc1ccccc1N1CCN(C(=O)N[C@@H]2CCc3c(O)cccc32)CC1 to have a lower LogP value.,COc1ccccc1N1CCN(C(=O)N[C@@H]2CCc3c(O)cccc32)CC1,2.919900000000001
+104131,Please optimize the molecule CCn1nc(C)c2nc([C@@H](C)Cl)n(CC3CCOCC3)c21 to have a higher LogP value.,CCn1nc(C)c2nc([C@@H](C)Cl)n(CC3CCOCC3)c21,3.2875200000000016
+133689,Modify the molecule CCOc1ccc2cc(C(=O)Nc3cccc(Cl)c3Cl)c(=O)oc2c1 to decrease its LogP value.,CCOc1ccc2cc(C(=O)Nc3cccc(Cl)c3Cl)c(=O)oc2c1,4.750800000000002
+81276,Modify the molecule CC1CC(NS(=O)(=O)c2ccc(F)cc2Cl)C1 to have a higher LogP value.,CC1CC(NS(=O)(=O)c2ccc(F)cc2Cl)C1,2.555900000000001
+230940,Optimize the molecule CCCCn1c(=O)[nH]c(=O)c2c1nc(-c1csc([N+](=O)[O-])c1)n2CC(C)C to have a lower LogP value.,CCCCn1c(=O)[nH]c(=O)c2c1nc(-c1csc([N+](=O)[O-])c1)n2CC(C)C,2.9791000000000016
+113725,Please optimize the molecule CCc1nnc(CN2CC[NH+](C3CCC(C(C)C)CC3)CC2)o1 to have a higher LogP value.,CCc1nnc(CN2CC[NH+](C3CCC(C(C)C)CC3)CC2)o1,1.5473
+174258,Modify the molecule CC(=O)c1ccc(N2C(=O)c3ccc(Oc4ccccc4)cc3C2=O)cc1 to have a lower LogP value.,CC(=O)c1ccc(N2C(=O)c3ccc(Oc4ccccc4)cc3C2=O)cc1,4.4821000000000035
+210072,Modify the molecule C[C@@H](Nc1nc2ccc(F)cn2n1)C(=O)N(C)C to increase its LogP value.,C[C@@H](Nc1nc2ccc(F)cn2n1)C(=O)N(C)C,0.7569999999999997
+191931,Optimize the molecule CC(=O)N1CCN(c2nccnc2[C@@H]2CCC[NH+]2C)CC1 to have a lower LogP value.,CC(=O)N1CCN(c2nccnc2[C@@H]2CCC[NH+]2C)CC1,-0.5052999999999981
+17852,Modify the molecule O=C(CNC(=O)Nc1cccc(OCC(F)(F)F)c1)NC1CC1 to have a higher LogP value.,O=C(CNC(=O)Nc1cccc(OCC(F)(F)F)c1)NC1CC1,2.0278
+206994,Modify the molecule O=C([C@@H]1CCCN(C2CC[NH+](Cc3ccccc3)CC2)C1)N1CCCCCCC1 to decrease its LogP value.,O=C([C@@H]1CCCN(C2CC[NH+](Cc3ccccc3)CC2)C1)N1CCCCCCC1,2.7386000000000017
+36172,Modify the molecule CN(CCNC(=O)Nc1ccccc1CC(N)=O)c1ccccc1 to have a lower LogP value.,CN(CCNC(=O)Nc1ccccc1CC(N)=O)c1ccccc1,1.9722999999999997
+175747,Please modify the molecule CC(C)[NH2+]Cc1ccn(Cc2nccs2)n1 to increase its LogP value.,CC(C)[NH2+]Cc1ccn(Cc2nccs2)n1,0.8596999999999991
+176943,Modify the molecule O=S1(=O)CC[C@H](NC(=S)N[C@H]2CCS(=O)(=O)C2)C1 to increase its LogP value.,O=S1(=O)CC[C@H](NC(=S)N[C@H]2CCS(=O)(=O)C2)C1,-1.175299999999999
+105891,Please optimize the molecule O=C(N[C@H]1C[C@H]2C(=O)N3CCC[C@@H]3C(=O)N2C1)c1ccc(F)c(C(F)(F)F)c1 to have a higher LogP value.,O=C(N[C@H]1C[C@H]2C(=O)N3CCC[C@@H]3C(=O)N2C1)c1ccc(F)c(C(F)(F)F)c1,1.5484000000000004
+172048,Optimize the molecule CC[NH+]1CCN(c2ccc(C(=O)N[C@H](C)C(C)C)cc2)CC1 to have a lower LogP value.,CC[NH+]1CCN(c2ccc(C(=O)N[C@H](C)C(C)C)cc2)CC1,1.1857000000000018
+44755,Please modify the molecule Cn1ccnc1[C@H](O)[C@H]1CCC[NH+](Cc2cccc(-c3cccnc3)c2)C1 to increase its LogP value.,Cn1ccnc1[C@H](O)[C@H]1CCC[NH+](Cc2cccc(-c3cccnc3)c2)C1,2.0105999999999997
+13454,Modify the molecule CC[C@H](C)C(=O)N1CCc2ccc(NC(=O)c3ccc(C(F)(F)F)cc3)cc2C1 to decrease its LogP value.,CC[C@H](C)C(=O)N1CCc2ccc(NC(=O)c3ccc(C(F)(F)F)cc3)cc2C1,4.888500000000004
+108536,Modify the molecule COc1cc(Cl)ccc1C(=O)NNC(=O)CC(C)(C)C to increase its LogP value.,COc1cc(Cl)ccc1C(=O)NNC(=O)CC(C)(C)C,2.5458000000000007
+92424,Please modify the molecule CCN1CCO[C@@H](C(=O)N[C@@H](C#N)c2cccc(Cl)c2)C1 to increase its LogP value.,CCN1CCO[C@@H](C(=O)N[C@@H](C#N)c2cccc(Cl)c2)C1,1.74158
+143601,Please optimize the molecule O=C(c1cc2ccccc2[nH]1)N1CCN(Cc2nc3ccccc3[nH]2)CC1 to have a higher LogP value.,O=C(c1cc2ccccc2[nH]1)N1CCN(Cc2nc3ccccc3[nH]2)CC1,3.002200000000001
+233729,Please optimize the molecule C[NH+]1CCN2c3ccc([N+](=O)[O-])cc3C[C@]3(C(=O)N(c4ccc(F)cc4)C(=O)N=C3[O-])[C@@H]2C1 to have a lower LogP value.,C[NH+]1CCN2c3ccc([N+](=O)[O-])cc3C[C@]3(C(=O)N(c4ccc(F)cc4)C(=O)N=C3[O-])[C@@H]2C1,-0.09469999999999867
+33476,Please optimize the molecule COC[C@@](C)(O)CNC(=O)C1(c2ccc(F)cc2)CC1 to have a higher LogP value.,COC[C@@](C)(O)CNC(=O)C1(c2ccc(F)cc2)CC1,1.3708999999999996
+18190,Modify the molecule O=S(=O)(c1cccnc1)N1CCC(O)(C(F)(F)F)CC1 to have a lower LogP value.,O=S(=O)(c1cccnc1)N1CCC(O)(C(F)(F)F)CC1,1.1595000000000002
+99417,Optimize the molecule Cc1ccc(-c2nnco2)cc1NC(=O)N1CCC[C@H](O)C1 to have a lower LogP value.,Cc1ccc(-c2nnco2)cc1NC(=O)N1CCC[C@H](O)C1,2.03362
+217190,Please modify the molecule CCCCN1CNc2c(c(=O)[nH]c(=O)n2CCc2ccccc2)C1 to decrease its LogP value.,CCCCN1CNc2c(c(=O)[nH]c(=O)n2CCc2ccccc2)C1,1.7643999999999993
+34295,Please optimize the molecule Cc1ncc(CSCCCC(C)(C)C#N)s1 to have a higher LogP value.,Cc1ncc(CSCCCC(C)(C)C#N)s1,4.014700000000003
+67528,Optimize the molecule C[C@@H](C(=O)Nc1nccs1)N1CCN(C2=[NH+]CC(C)(C)S2)CC1 to have a higher LogP value.,C[C@@H](C(=O)Nc1nccs1)N1CCN(C2=[NH+]CC(C)(C)S2)CC1,0.04970000000000163
+69514,Please modify the molecule CCS(=O)(=O)C[C@H](C)N(C)C(=O)Nc1cnn(Cc2ccccc2)c1 to decrease its LogP value.,CCS(=O)(=O)C[C@H](C)N(C)C(=O)Nc1cnn(Cc2ccccc2)c1,2.2182999999999993
+76953,Please modify the molecule Nc1cc(-c2c[nH]nc2[C@H]2CCCN(S(=O)(=O)c3ccccc3)C2)ccn1 to decrease its LogP value.,Nc1cc(-c2c[nH]nc2[C@H]2CCCN(S(=O)(=O)c3ccccc3)C2)ccn1,2.622200000000001
+98543,Optimize the molecule COc1ccccc1[C@@H](C)NC(=O)Cc1csc(-c2ccccc2)n1 to have a lower LogP value.,COc1ccccc1[C@@H](C)NC(=O)Cc1csc(-c2ccccc2)n1,4.238600000000003
+218223,Optimize the molecule COC[C@H](NC(=O)[C@H](C)Oc1cccc(Br)c1)C(N)=O to have a lower LogP value.,COC[C@H](NC(=O)[C@H](C)Oc1cccc(Br)c1)C(N)=O,0.8328999999999995
+202165,Modify the molecule C[NH+](C)[C@H](CNS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1)c1ccccc1 to decrease its LogP value.,C[NH+](C)[C@H](CNS(=O)(=O)c1ccc(Cl)c(C(F)(F)F)c1)c1ccccc1,2.5229000000000017
+10525,Modify the molecule COc1ccc([C@@H](O)[C@@H](C)NC(=O)CN2CCCCCC2=O)cc1 to have a lower LogP value.,COc1ccc([C@@H](O)[C@@H](C)NC(=O)CN2CCCCCC2=O)cc1,1.6358999999999992
+184600,Modify the molecule CCCc1cc(C(=O)NC[C@@H]2CC[C@H](C(=O)[O-])O2)sc1C to decrease its LogP value.,CCCc1cc(C(=O)NC[C@@H]2CC[C@H](C(=O)[O-])O2)sc1C,1.0363199999999997
+63019,Please modify the molecule Cc1cccc2cc([C@@H](c3nnnn3C[C@H]3CCCO3)[NH+]3CCCCC3)c(=O)[nH]c12 to increase its LogP value.,Cc1cccc2cc([C@@H](c3nnnn3C[C@H]3CCCO3)[NH+]3CCCCC3)c(=O)[nH]c12,1.16022
+133040,Please modify the molecule CCNC(=O)C[NH2+]Cc1csc(C(C)(C)C)n1 to increase its LogP value.,CCNC(=O)C[NH2+]Cc1csc(C(C)(C)C)n1,0.6401000000000001
+241714,Please modify the molecule Cc1cc(C)c(NC(=S)N(Cc2cccnc2)Cc2cccnc2)c(C)c1 to increase its LogP value.,Cc1cc(C)c(NC(=S)N(Cc2cccnc2)Cc2cccnc2)c(C)c1,4.801060000000004
+212832,Please optimize the molecule CCN(CC)c1ncnc2c1cnn2CC(=O)Nc1cc(C)ccc1OC to have a lower LogP value.,CCN(CC)c1ncnc2c1cnn2CC(=O)Nc1cc(C)ccc1OC,2.6282200000000007
+154970,Please optimize the molecule Nc1cccc(Cl)c1SCCOc1ccccc1 to have a higher LogP value.,Nc1cccc(Cl)c1SCCOc1ccccc1,4.093300000000002
+148696,Modify the molecule Cc1cccc(Oc2ccc(Cl)cc2NC(=O)Cn2cc[nH+]c2)c1 to have a higher LogP value.,Cc1cccc(Oc2ccc(Cl)cc2NC(=O)Cn2cc[nH+]c2)c1,3.6950200000000013
+155842,Optimize the molecule C[C@@H]1CN(c2c(F)c(F)nc(F)c2F)CCCO1 to have a lower LogP value.,C[C@@H]1CN(c2c(F)c(F)nc(F)c2F)CCCO1,2.2532000000000005
+231346,Modify the molecule C[C@H](C(=O)Nc1ccc2oc(=O)[nH]c2c1)c1ccsc1 to have a higher LogP value.,C[C@H](C(=O)Nc1ccc2oc(=O)[nH]c2c1)c1ccsc1,2.9248000000000003
+126863,Modify the molecule C[C@@H]1[C@H](C(=O)[O-])CCN1C(=O)C1CCC(C(C)(C)C)CC1 to increase its LogP value.,C[C@@H]1[C@H](C(=O)[O-])CCN1C(=O)C1CCC(C(C)(C)C)CC1,1.8257999999999996
+10453,Optimize the molecule Cc1cc(C)c(NNC(=O)[C@H](C)OCC(F)(F)F)c(C)c1 to have a lower LogP value.,Cc1cc(C)c(NNC(=O)[C@H](C)OCC(F)(F)F)c(C)c1,3.0223600000000017
+198115,Optimize the molecule C[C@@H](C(=O)N(C)Cc1ccc(O)cc1)S(C)(=O)=O to have a lower LogP value.,C[C@@H](C(=O)N(C)Cc1ccc(O)cc1)S(C)(=O)=O,0.7837000000000001
+116387,Optimize the molecule COc1ccc2c(c1)[C@H]([NH2+]CCNc1ncccc1C(F)(F)F)CCO2 to have a lower LogP value.,COc1ccc2c(c1)[C@H]([NH2+]CCNc1ncccc1C(F)(F)F)CCO2,2.6081000000000003
+51625,Modify the molecule O=C(c1ccc(Cl)cc1F)N1CCN(Cc2cc[nH]n2)CC1 to have a higher LogP value.,O=C(c1ccc(Cl)cc1F)N1CCN(Cc2cc[nH]n2)CC1,2.1601999999999997
+118738,Optimize the molecule CC[C@H]1CCCN(C(=O)CC2([NH3+])CCC2)C1 to have a lower LogP value.,CC[C@H]1CCCN(C(=O)CC2([NH3+])CCC2)C1,1.1897000000000002
+147248,Optimize the molecule O=C([O-])[C@@H]1CCCN(C(=O)c2cc(Br)c[nH]2)C1 to have a higher LogP value.,O=C([O-])[C@@H]1CCCN(C(=O)c2cc(Br)c[nH]2)C1,0.3793
+181759,Please optimize the molecule Cc1cc(C)c2nc(SCC(=O)c3ccc4c(c3)OCCO4)c(C#N)cc2c1 to have a lower LogP value.,Cc1cc(C)c2nc(SCC(=O)c3ccc4c(c3)OCCO4)c(C#N)cc2c1,4.469520000000004
+161179,Modify the molecule C[C@@H]1CCCN(C(=O)c2cccc(S(=O)(=O)NCCc3ccncc3)c2)C1 to increase its LogP value.,C[C@@H]1CCCN(C(=O)c2cccc(S(=O)(=O)NCCc3ccncc3)c2)C1,2.4747000000000003
+50822,Please optimize the molecule Cc1cc(C)n2nc(CC(=O)O[C@H](C)c3nc4ccccc4n3C)nc2n1 to have a higher LogP value.,Cc1cc(C)n2nc(CC(=O)O[C@H](C)c3nc4ccccc4n3C)nc2n1,2.4747400000000006
+42722,Please modify the molecule CCS(=O)(=O)N1CCc2cc(C(=O)Nc3ccc(Oc4ccccc4)cc3)ccc21 to decrease its LogP value.,CCS(=O)(=O)N1CCc2cc(C(=O)Nc3ccc(Oc4ccccc4)cc3)ccc21,4.443400000000003
+127969,Optimize the molecule CC(C)[C@H](CO)NC(=O)NC12CC3CC(CC(C3)C1)C2 to have a higher LogP value.,CC(C)[C@H](CO)NC(=O)NC12CC3CC(CC(C3)C1)C2,2.2713
+73271,Modify the molecule CNC(=O)CSCc1nc(C)cs1 to have a higher LogP value.,CNC(=O)CSCc1nc(C)cs1,1.43072
+54720,Modify the molecule O=C([C@H]1Cc2ccccc2O1)N1CCCC[C@@H]1c1nccs1 to have a lower LogP value.,O=C([C@H]1Cc2ccccc2O1)N1CCCC[C@@H]1c1nccs1,3.200400000000002
+157136,Optimize the molecule Cc1cc(C(=O)N2CCCC2)ccc1NC(=O)NC[C@H](C)c1ccsc1 to have a higher LogP value.,Cc1cc(C(=O)N2CCCC2)ccc1NC(=O)NC[C@H](C)c1ccsc1,4.217720000000003
+173035,Please modify the molecule Cc1ccc([C@@H](O)[C@]2(C[NH3+])CCOC2)o1 to decrease its LogP value.,Cc1ccc([C@@H](O)[C@]2(C[NH3+])CCOC2)o1,0.27001999999999954
+24322,Please modify the molecule Cc1ccc(S(=O)(=O)/N=C(\[O-])[C@H]2SCCc3ccccc32)c(F)c1 to increase its LogP value.,Cc1ccc(S(=O)(=O)/N=C(\[O-])[C@H]2SCCc3ccccc32)c(F)c1,2.6122200000000007
+181838,Please modify the molecule Cc1ccc(C(=O)Oc2ccc(N3C(=O)CCC3=O)c(C)c2)cc1 to decrease its LogP value.,Cc1ccc(C(=O)Oc2ccc(N3C(=O)CCC3=O)c(C)c2)cc1,3.176040000000002
+6024,Modify the molecule CO[C@H]1CCC[C@@H](OC(=O)c2ccc(Cl)c(N3CCNC3=O)c2)C1 to have a lower LogP value.,CO[C@H]1CCC[C@@H](OC(=O)c2ccc(Cl)c(N3CCNC3=O)c2)C1,2.984000000000001
+131350,Optimize the molecule CN(c1ccccc1)c1ccccc1C(=O)Nc1nccn(C)c1=O to have a higher LogP value.,CN(c1ccccc1)c1ccccc1C(=O)Nc1nccn(C)c1=O,2.8005000000000004
+180314,Please modify the molecule O=C(c1cc(Br)c[nH]1)N1CCc2ccc(Cl)cc2C1 to decrease its LogP value.,O=C(c1cc(Br)c[nH]1)N1CCc2ccc(Cl)cc2C1,3.629100000000002
+141871,Please optimize the molecule CN(CCCc1ccccc1)C(=O)c1[nH]ncc1Br to have a higher LogP value.,CN(CCCc1ccccc1)C(=O)c1[nH]ncc1Br,2.8770000000000007
+64867,Modify the molecule C[C@@H](NC(=O)CSc1nc2ccccc2n1C)c1ccco1 to have a higher LogP value.,C[C@@H](NC(=O)CSc1nc2ccccc2n1C)c1ccco1,3.1358000000000015
+196812,Optimize the molecule COc1ccc(OCC(=O)N(C)Cc2ccc(N(C)C)cc2)cc1 to have a higher LogP value.,COc1ccc(OCC(=O)N(C)Cc2ccc(N(C)C)cc2)cc1,2.7986000000000013
+1050,Optimize the molecule Cc1cccc(NC(=O)[C@@H](C)[NH+]2CCC[C@H](c3nncn3C3CC3)C2)c1 to have a higher LogP value.,Cc1cccc(NC(=O)[C@@H](C)[NH+]2CCC[C@H](c3nncn3C3CC3)C2)c1,1.710919999999999
+8555,Modify the molecule C#CCN(CC#C)CC(=O)NCc1ccc(OC)cc1 to have a lower LogP value.,C#CCN(CC#C)CC(=O)NCc1ccc(OC)cc1,0.8797999999999995
+43280,Modify the molecule O=C(NCCNc1cccc[nH+]1)c1ccc(Br)c(O)c1 to increase its LogP value.,O=C(NCCNc1cccc[nH+]1)c1ccc(Br)c(O)c1,1.8106999999999993
+111413,Please modify the molecule CC(=O)NCCc1ccc(C(=O)c2cc3cc(Cl)ccc3o2)cc1 to increase its LogP value.,CC(=O)NCCc1ccc(C(=O)c2cc3cc(Cl)ccc3o2)cc1,3.9958000000000027
+155773,Please modify the molecule Cc1ccc(S(=O)(=O)N/N=C/c2cn(-c3ccccc3)nc2-c2ccccc2)cc1 to increase its LogP value.,Cc1ccc(S(=O)(=O)N/N=C/c2cn(-c3ccccc3)nc2-c2ccccc2)cc1,4.160120000000003
+158003,Modify the molecule Cc1cc([C@@H]2CCCN2C(=O)Cc2cn(C)c3ccccc23)no1 to increase its LogP value.,Cc1cc([C@@H]2CCCN2C(=O)Cc2cn(C)c3ccccc23)no1,3.3809200000000024
+78522,Optimize the molecule Cc1ocnc1C(=O)N1CC[C@]2(CCC[NH+](CCC3CCCCC3)C2)C1 to have a lower LogP value.,Cc1ocnc1C(=O)N1CC[C@]2(CCC[NH+](CCC3CCCCC3)C2)C1,2.4644199999999996
+150410,Please modify the molecule O=S(=O)(N/N=C1\CCCC[C@H]1c1ccccc1)c1ccccc1 to decrease its LogP value.,O=S(=O)(N/N=C1\CCCC[C@H]1c1ccccc1)c1ccccc1,3.6787000000000027
+234815,Modify the molecule O=C(CCc1c[nH]c2ccccc12)Nc1ccc(F)cc1OCC(F)F to have a higher LogP value.,O=C(CCc1c[nH]c2ccccc12)Nc1ccc(F)cc1OCC(F)F,4.522200000000002
+87885,Optimize the molecule CCc1ccc(CN[C@H](CC)C(=O)Nc2cc(C)on2)s1 to have a lower LogP value.,CCc1ccc(CN[C@H](CC)C(=O)Nc2cc(C)on2)s1,3.1138200000000014
+197047,Modify the molecule CCCn1cc(N)c(=O)n(C[C@@H]2CN(C)CCO2)c1=O to have a lower LogP value.,CCCn1cc(N)c(=O)n(C[C@@H]2CN(C)CCO2)c1=O,-0.6671999999999991
+113393,Please optimize the molecule N#Cc1ccc(N2CCC(C(=O)NCc3ccccc3F)CC2)nc1 to have a lower LogP value.,N#Cc1ccc(N2CCC(C(=O)NCc3ccccc3F)CC2)nc1,2.625180000000001
+77776,Optimize the molecule CC[C@@](C)(NC(=O)CN1CCCOC1=O)c1nc(C)cs1 to have a higher LogP value.,CC[C@@](C)(NC(=O)CN1CCCOC1=O)c1nc(C)cs1,2.0352200000000003
+200559,Please optimize the molecule O=C(NCc1cccnc1OCc1ccccc1)N1CCC[C@@H](O)C1 to have a higher LogP value.,O=C(NCc1cccnc1OCc1ccccc1)N1CCC[C@@H](O)C1,2.3269
+84499,Please modify the molecule C[NH2+][C@@]1(C(=O)[O-])CCC[C@H](N(C)C2CC[NH+](C)CC2)C1 to increase its LogP value.,C[NH2+][C@@]1(C(=O)[O-])CCC[C@H](N(C)C2CC[NH+](C)CC2)C1,-2.7801999999999945
+114204,Modify the molecule CC(CO)(CO)NC(=O)Nc1cc(Cl)ccc1OCC(F)(F)F to decrease its LogP value.,CC(CO)(CO)NC(=O)Nc1cc(Cl)ccc1OCC(F)(F)F,2.1459
+240602,Please modify the molecule CC(C)C(=O)Nc1nnc(Cc2ccc(Cl)cc2)s1 to increase its LogP value.,CC(C)C(=O)Nc1nnc(Cc2ccc(Cl)cc2)s1,3.376800000000002
+217183,Modify the molecule COc1nc2c(cc1C(=O)NCc1cnc(SC)n1C)CCC2 to decrease its LogP value.,COc1nc2c(cc1C(=O)NCc1cnc(SC)n1C)CCC2,1.9643
+205602,Modify the molecule C[C@@H](CCO)C[NH2+]C[C@H]1CN(C)CCO1 to have a lower LogP value.,C[C@@H](CCO)C[NH2+]C[C@H]1CN(C)CCO1,-1.101099999999998
+23057,Modify the molecule CC(=O)NCCc1cc(C)no1 to decrease its LogP value.,CC(=O)NCCc1cc(C)no1,0.6616200000000001
+249061,Optimize the molecule NC(=O)C[NH+](CC(=O)N1CCC[C@@H](C(F)(F)F)C1)C1CCCC1 to have a lower LogP value.,NC(=O)C[NH+](CC(=O)N1CCC[C@@H](C(F)(F)F)C1)C1CCCC1,0.10010000000000163
+127231,Modify the molecule O=C([O-])CC1(CSC[C@H]2C[C@H]3CC[C@@H]2C3)CC1 to have a lower LogP value.,O=C([O-])CC1(CSC[C@H]2C[C@H]3CC[C@@H]2C3)CC1,2.0759999999999996
+166139,Optimize the molecule CCCCN1C(=O)[C@@H]2[C@H]3CCCN3[C@]3(C(=O)Nc4ccc(Br)cc43)[C@@H]2C1=O to have a higher LogP value.,CCCCN1C(=O)[C@@H]2[C@H]3CCCN3[C@]3(C(=O)Nc4ccc(Br)cc43)[C@@H]2C1=O,2.4758000000000004
+144968,Please modify the molecule C[NH2+][C@@H](CC[C@@H]1CCCCO1)[C@H](C)c1ccccn1 to increase its LogP value.,C[NH2+][C@@H](CC[C@@H]1CCCCO1)[C@H](C)c1ccccn1,2.0961999999999996
+143572,Optimize the molecule Cc1ccc2sc(N(CC[NH+](C)C)C(=O)Cc3ccccc3)nc2c1C to have a lower LogP value.,Cc1ccc2sc(N(CC[NH+](C)C)C(=O)Cc3ccccc3)nc2c1C,2.6333400000000005
+234780,Modify the molecule Cc1ccccc1NS(=O)(=O)c1cc2c3c(c1)CC(=O)N3CCC2 to increase its LogP value.,Cc1ccccc1NS(=O)(=O)c1cc2c3c(c1)CC(=O)N3CCC2,2.631120000000001
+185028,Modify the molecule Cn1cccc(C(=O)N2CCC(CNC(=O)c3cnc4ccccc4n3)CC2)c1=O to decrease its LogP value.,Cn1cccc(C(=O)N2CCC(CNC(=O)c3cnc4ccccc4n3)CC2)c1=O,1.6106999999999998
+19027,Please modify the molecule CC[NH2+][C@@H](c1ccsc1)[C@@H]1CCOC2(CCCC2)C1 to decrease its LogP value.,CC[NH2+][C@@H](c1ccsc1)[C@@H]1CCOC2(CCCC2)C1,3.111900000000002
+34696,Optimize the molecule CCN(C(=O)Nc1cccnc1-n1cccn1)[C@H](C)c1cccc(OC)c1 to have a higher LogP value.,CCN(C(=O)Nc1cccnc1-n1cccn1)[C@H](C)c1cccc(OC)c1,3.890900000000003
+60916,Please optimize the molecule Cc1nc(C)c(C(=O)N2CSC[C@@H]2C(=O)NC(C)(C)C)o1 to have a higher LogP value.,Cc1nc(C)c(C(=O)N2CSC[C@@H]2C(=O)NC(C)(C)C)o1,1.7212399999999997
+12380,Please optimize the molecule COc1cc([C@H]2c3cc4c(cc3O[C@@](C)([NH+]3CCCC3)[C@@H]2C)OCO4)cc(OC)c1OC to have a lower LogP value.,COc1cc([C@H]2c3cc4c(cc3O[C@@](C)([NH+]3CCCC3)[C@@H]2C)OCO4)cc(OC)c1OC,2.9964000000000013
+138815,Modify the molecule Cc1csc(N2CCN(CCn3cncn3)CC2)n1 to increase its LogP value.,Cc1csc(N2CCN(CCn3cncn3)CC2)n1,0.8652199999999999
+174125,Please optimize the molecule CCCc1nnc2n1N[C@H](c1ccccc1)[C@H](C(=O)Nc1cc(C)cc(C)c1)S2 to have a lower LogP value.,CCCc1nnc2n1N[C@H](c1ccccc1)[C@H](C(=O)Nc1cc(C)cc(C)c1)S2,4.245240000000003
+4699,Modify the molecule CC[NH2+][C@H]([C@@H]1CN2CCC[C@@H]2CO1)[C@@H]1CCCC[C@H]1CC to increase its LogP value.,CC[NH2+][C@H]([C@@H]1CN2CCC[C@@H]2CO1)[C@@H]1CCCC[C@H]1CC,2.0178999999999996
+66232,Please modify the molecule Cc1nn(-c2ccc(F)cc2F)c(C)c1C[NH+]1C[C@@H]2CCC[C@H](C1)C2O to increase its LogP value.,Cc1nn(-c2ccc(F)cc2F)c(C)c1C[NH+]1C[C@@H]2CCC[C@H](C1)C2O,1.9430400000000003
+176522,Please optimize the molecule CN1CC2(CCN(Cc3[nH+]ccn3C)CC2)OC1=O to have a higher LogP value.,CN1CC2(CCN(Cc3[nH+]ccn3C)CC2)OC1=O,0.25580000000000047
+58310,Please modify the molecule O=C(Nc1ccc(-c2ccccc2)cc1)C(=O)N1CC[C@H]([NH+]2CCCC2)C1 to decrease its LogP value.,O=C(Nc1ccc(-c2ccccc2)cc1)C(=O)N1CC[C@H]([NH+]2CCCC2)C1,1.5716999999999994
+193037,Modify the molecule CN(C(=O)CSc1nnc(-c2ccncc2)o1)C1CCCCC1 to increase its LogP value.,CN(C(=O)CSc1nnc(-c2ccncc2)o1)C1CCCCC1,3.014800000000001
+147325,Modify the molecule COc1ccc2nc(N(Cc3cccnc3)C(=O)c3ccc(C(F)(F)F)cc3)sc2c1 to decrease its LogP value.,COc1ccc2nc(N(Cc3cccnc3)C(=O)c3ccc(C(F)(F)F)cc3)sc2c1,5.565700000000003
+239800,Please optimize the molecule C[C@@H](NS(=O)(=O)Cc1ccon1)c1cccc(Cl)c1 to have a higher LogP value.,C[C@@H](NS(=O)(=O)Cc1ccon1)c1cccc(Cl)c1,2.5086000000000004
+197622,Please modify the molecule N#CCOc1cccc(CC(=O)N2CCC2)c1 to decrease its LogP value.,N#CCOc1cccc(CC(=O)N2CCC2)c1,1.36378
+19751,Please optimize the molecule COc1ccc(SCCC(=O)Nc2nnc(-c3cc(Cl)sc3Cl)o2)cc1 to have a lower LogP value.,COc1ccc(SCCC(=O)Nc2nnc(-c3cc(Cl)sc3Cl)o2)cc1,5.234400000000003
+189032,Please optimize the molecule COCCCN1C(=O)c2cccc(N3CC[NH+](Cc4ccc5c(c4)Cc4ccccc4-5)CC3)c2C1=O to have a higher LogP value.,COCCCN1C(=O)c2cccc(N3CC[NH+](Cc4ccc5c(c4)Cc4ccccc4-5)CC3)c2C1=O,2.7954000000000017
+55951,Modify the molecule COc1ccc(N2CCN(C(=O)[C@@H](NC(=O)c3cccc(C)c3)C(C)C)CC2)cc1 to decrease its LogP value.,COc1ccc(N2CCN(C(=O)[C@@H](NC(=O)c3cccc(C)c3)C(C)C)CC2)cc1,3.106820000000001
+58420,Please optimize the molecule Cc1cccc(-c2nn3c(=O)cc(N4CCN(S(=O)(=O)c5ccc(F)cc5)CC4)nc3s2)c1 to have a higher LogP value.,Cc1cccc(-c2nn3c(=O)cc(N4CCN(S(=O)(=O)c5ccc(F)cc5)CC4)nc3s2)c1,2.7764200000000008
+11707,Optimize the molecule CC(C)c1n[nH]c(/N=C(\[O-])[C@H]2SCCc3ccccc32)n1 to have a lower LogP value.,CC(C)c1n[nH]c(/N=C(\[O-])[C@H]2SCCc3ccccc32)n1,2.349
+235381,Optimize the molecule CCOC(=O)[C@@H](C)n1cnc2sc(C(=O)Nc3ccc(C)cc3C)c(C)c2c1=O to have a lower LogP value.,CCOC(=O)[C@@H](C)n1cnc2sc(C(=O)Nc3ccc(C)cc3C)c(C)c2c1=O,3.759660000000002
+226233,Please optimize the molecule CCn1cnnc1-c1cccc(NC(=O)[C@H]2CCCN(C(=O)c3ccc(Cl)cc3)C2)c1 to have a lower LogP value.,CCn1cnnc1-c1cccc(NC(=O)[C@H]2CCCN(C(=O)c3ccc(Cl)cc3)C2)c1,4.109300000000003
+246809,Modify the molecule CC(C)C(=O)N[C@@H]1CCC[C@@H]1c1ccccc1C(F)(F)F to have a lower LogP value.,CC(C)C(=O)N[C@@H]1CCC[C@@H]1c1ccccc1C(F)(F)F,4.113700000000003
+67970,Optimize the molecule CC(=O)N1CCC([NH2+]CCOc2ccc(Cl)cc2)CC1 to have a higher LogP value.,CC(=O)N1CCC([NH2+]CCOc2ccc(Cl)cc2)CC1,1.2931000000000004
+12968,Optimize the molecule Cc1cc(C)nc([C@H](C#N)C(=O)c2ccc([N+](=O)[O-])cc2)n1 to have a lower LogP value.,Cc1cc(C)nc([C@H](C#N)C(=O)c2ccc([N+](=O)[O-])cc2)n1,2.49172
+16639,Optimize the molecule CC(C)C(=O)N(C)c1nc(-c2ccc3c(c2)CCCN3C(=O)C2CCCC2)cs1 to have a higher LogP value.,CC(C)C(=O)N(C)c1nc(-c2ccc3c(c2)CCCN3C(=O)C2CCCC2)cs1,4.898300000000005
+56551,Optimize the molecule Cc1nn(C)cc1NC(=S)Nc1ccc(S(N)(=O)=O)cc1 to have a higher LogP value.,Cc1nn(C)cc1NC(=S)Nc1ccc(S(N)(=O)=O)cc1,1.1848199999999998
+39374,Modify the molecule N#Cc1c2ncn(CC(=O)c3ccc(Br)cc3)c(=O)c2c2n1CCC2 to have a higher LogP value.,N#Cc1c2ncn(CC(=O)c3ccc(Br)cc3)c(=O)c2c2n1CCC2,2.6612800000000005
+107858,Please optimize the molecule CN(C)CC[NH+]1CCC(NC(=O)NC[C@@H]2CN3CCCC[C@@H]3CO2)CC1 to have a lower LogP value.,CN(C)CC[NH+]1CCC(NC(=O)NC[C@@H]2CN3CCCC[C@@H]3CO2)CC1,-0.8521999999999941
+144427,Modify the molecule O=C1C[C@@H](C(=O)N2CCN(c3nccs3)CC2)CN1Cc1ccccn1 to decrease its LogP value.,O=C1C[C@@H](C(=O)N2CCN(c3nccs3)CC2)CN1Cc1ccccn1,1.2353999999999992
+33708,Please optimize the molecule O=C(Nc1cc2c(cc1Cl)OCO2)[C@H]1COc2ccc(F)cc2C1 to have a lower LogP value.,O=C(Nc1cc2c(cc1Cl)OCO2)[C@H]1COc2ccc(F)cc2C1,3.3976000000000024
+1220,Modify the molecule C=CCN1C(=O)/C(=C/c2cccc(C)c2)S/C1=N/c1nnc(C)s1 to have a lower LogP value.,C=CCN1C(=O)/C(=C/c2cccc(C)c2)S/C1=N/c1nnc(C)s1,3.9449400000000034
+118033,Please modify the molecule [O-]/C(=C\SCc1ccccc1)N1CCc2ccccc21 to decrease its LogP value.,[O-]/C(=C\SCc1ccccc1)N1CCc2ccccc21,3.141700000000002
+136189,Optimize the molecule O=Cc1cc(OCc2ccccc2)ccc1Br to have a lower LogP value.,O=Cc1cc(OCc2ccccc2)ccc1Br,3.840600000000002
+98152,Please modify the molecule Cc1ccccc1-c1noc(=O)n1CC(=O)Nc1c(C)nn(C)c1C to increase its LogP value.,Cc1ccccc1-c1noc(=O)n1CC(=O)Nc1c(C)nn(C)c1C,1.8007599999999997
+147528,Modify the molecule O=C([O-])Cc1ccc(NC(=O)c2ccc(N3C(=O)c4ccccc4C3=O)cc2)cc1 to have a higher LogP value.,O=C([O-])Cc1ccc(NC(=O)c2ccc(N3C(=O)c4ccccc4C3=O)cc2)cc1,2.0318999999999994
+189417,Please modify the molecule CCC[NH+](CC)[C@H](C)C(=O)Nc1c(Cl)cc(N)cc1Cl to increase its LogP value.,CCC[NH+](CC)[C@H](C)C(=O)Nc1c(Cl)cc(N)cc1Cl,2.2173999999999996
+36992,Modify the molecule CNC(=O)[C@H](C)Sc1nncn1C to increase its LogP value.,CNC(=O)[C@H](C)Sc1nncn1C,0.041699999999999404
+214658,Modify the molecule CC(C)[C@H]1C[C@@](O)(Cc2nc3ccccc3s2)CCO1 to decrease its LogP value.,CC(C)[C@H]1C[C@@](O)(Cc2nc3ccccc3s2)CCO1,3.4049000000000023
+177111,Modify the molecule Cc1ccnc(NNC(=O)c2ccc(S(=O)(=O)N(C)C)cc2)c1 to have a lower LogP value.,Cc1ccnc(NNC(=O)c2ccc(S(=O)(=O)N(C)C)cc2)c1,1.39722
+222227,Please modify the molecule c1ccc(-c2nnn3c2nc(NCc2cccnc2)c2ccccc23)cc1 to decrease its LogP value.,c1ccc(-c2nnn3c2nc(NCc2cccnc2)c2ccccc23)cc1,3.9516000000000027
+140030,Modify the molecule COc1ccccc1N(C)S(=O)(=O)c1ccc(C(=O)N2CCCCC[C@@H]2c2cccn2C)cc1 to have a lower LogP value.,COc1ccccc1N(C)S(=O)(=O)c1ccc(C(=O)N2CCCCC[C@@H]2c2cccn2C)cc1,4.616300000000004
+111109,Modify the molecule CC(=O)c1ccc(S(=O)(=O)N2CCO[C@@H](c3ccc(Cl)cc3)C2)cc1 to decrease its LogP value.,CC(=O)c1ccc(S(=O)(=O)N2CCO[C@@H](c3ccc(Cl)cc3)C2)cc1,3.304800000000002
+230812,Please optimize the molecule O=C(Nc1cc(Cl)ccc1OCC(F)(F)F)c1ccnnc1 to have a lower LogP value.,O=C(Nc1cc(Cl)ccc1OCC(F)(F)F)c1ccnnc1,3.3234000000000012
+113610,Please modify the molecule C=C(C)[C@H](O)C1CCC(C)CC1 to decrease its LogP value.,C=C(C)[C@H](O)C1CCC(C)CC1,2.7497000000000007
+246221,Modify the molecule CC(C)[C@H]1CC[C@H](C)C[C@@]1([NH3+])Cc1nccs1 to increase its LogP value.,CC(C)[C@H]1CC[C@H](C)C[C@@]1([NH3+])Cc1nccs1,2.7585000000000006
+7898,Modify the molecule Cc1ocnc1CNC(=O)N[C@@H]1CCCC[C@H]1CNC(=O)OC(C)(C)C to have a higher LogP value.,Cc1ocnc1CNC(=O)N[C@@H]1CCCC[C@H]1CNC(=O)OC(C)(C)C,2.8657200000000005
+223530,Optimize the molecule CSc1nsc(NC(=O)c2cnc(-c3cccs3)s2)n1 to have a higher LogP value.,CSc1nsc(NC(=O)c2cnc(-c3cccs3)s2)n1,3.6973000000000003
+18762,Modify the molecule CC(C)n1cnnc1SCC(=O)N(C)Cc1cnn(C)c1 to decrease its LogP value.,CC(C)n1cnnc1SCC(=O)N(C)Cc1cnn(C)c1,1.3431999999999997
+40040,Modify the molecule COc1ccc(C)cc1NC(=O)CSC1=NCCS1 to decrease its LogP value.,COc1ccc(C)cc1NC(=O)CSC1=NCCS1,2.7781200000000013
+98097,Optimize the molecule Cc1ccccc1C1(C(=O)NCCCc2c(C)noc2C)CCCCC1 to have a higher LogP value.,Cc1ccccc1C1(C(=O)NCCCc2c(C)noc2C)CCCCC1,4.550760000000005
+230463,Modify the molecule CC(C)NC(=O)CN1CCN(C(=O)NCCCn2cccn2)CC1 to have a higher LogP value.,CC(C)NC(=O)CN1CCN(C(=O)NCCCn2cccn2)CC1,0.12500000000000178
+95775,Please modify the molecule CCC1=C(C)N(C(C)(C)C(=O)[O-])N(C(=O)C(C)C)c2ccccc21 to increase its LogP value.,CCC1=C(C)N(C(C)(C)C(=O)[O-])N(C(=O)C(C)C)c2ccccc21,2.5757000000000003
+17034,Please optimize the molecule Cc1cc(C)n(CC(=O)N2CCC(n3c(C4CCC4)nc4cc(F)ccc43)CC2)n1 to have a lower LogP value.,Cc1cc(C)n(CC(=O)N2CCC(n3c(C4CCC4)nc4cc(F)ccc43)CC2)n1,4.119940000000003
+118901,Please modify the molecule COc1ccc(CCNCc2cnc(SC)nc2)cc1 to increase its LogP value.,COc1ccc(CCNCc2cnc(SC)nc2)cc1,2.5394000000000005
+178054,Modify the molecule CC[NH+](CC(=O)NC1(C#N)CCCCC1)C[C@H](O)c1ccc(C)cc1 to have a higher LogP value.,CC[NH+](CC(=O)NC1(C#N)CCCCC1)C[C@H](O)c1ccc(C)cc1,1.2759
+162856,Please modify the molecule C[C@@H]1CN(Cc2cccc(Cl)n2)CC[NH2+]1 to decrease its LogP value.,C[C@@H]1CN(Cc2cccc(Cl)n2)CC[NH2+]1,0.5025000000000001
+36649,Optimize the molecule CC[C@H](NC(=O)N[C@H]1CC[C@H](SC)C1)c1cccs1 to have a lower LogP value.,CC[C@H](NC(=O)N[C@H]1CC[C@H](SC)C1)c1cccs1,3.7825000000000024
+193208,Modify the molecule CCN1C(=O)N[C@H](c2cccc(F)c2)C2=C1CN(CCC(=O)NCC(C)C)C2=O to have a lower LogP value.,CCN1C(=O)N[C@H](c2cccc(F)c2)C2=C1CN(CCC(=O)NCC(C)C)C2=O,2.1704999999999997
+192365,Modify the molecule CN(Cc1ccncn1)c1ccc(-c2nc(Cc3ccc(F)cc3)no2)cn1 to increase its LogP value.,CN(Cc1ccncn1)c1ccc(-c2nc(Cc3ccc(F)cc3)no2)cn1,3.2879000000000014
+224276,Please optimize the molecule Cc1nc(NC(=O)c2cc3c([nH]c2=O)CCCC3)sc1-c1ccccc1 to have a lower LogP value.,Cc1nc(NC(=O)c2cc3c([nH]c2=O)CCCC3)sc1-c1ccccc1,3.9379200000000028
+240891,Modify the molecule CCOc1ccc(Br)cc1/C=C/C(=O)NCCC(=O)[O-] to have a higher LogP value.,CCOc1ccc(Br)cc1/C=C/C(=O)NCCC(=O)[O-],1.1171999999999993
+210355,Please optimize the molecule Cc1csc([C@H]2CCC[NH+](Cc3cc(C)oc3C)C2)n1 to have a higher LogP value.,Cc1csc([C@H]2CCC[NH+](Cc3cc(C)oc3C)C2)n1,2.6238600000000005
+109065,Please modify the molecule O=C(CCSc1ccc(F)cc1)NNC(=O)[C@@H]1C[C@@H]1[N+](=O)[O-] to decrease its LogP value.,O=C(CCSc1ccc(F)cc1)NNC(=O)[C@@H]1C[C@@H]1[N+](=O)[O-],1.1204999999999998
+223009,Modify the molecule C[C@@H]([NH3+])c1ccc(N(C)CCC(F)(F)F)cc1O to have a higher LogP value.,C[C@@H]([NH3+])c1ccc(N(C)CCC(F)(F)F)cc1O,2.0837000000000008
+6808,Modify the molecule COc1ccccc1C(C)(C)CNC(=O)c1c(C)nn(C)c1OC to increase its LogP value.,COc1ccccc1C(C)(C)CNC(=O)c1c(C)nn(C)c1OC,2.4533200000000006
+12085,Optimize the molecule CC[C@@H](CNC(=O)c1ccccc1F)Oc1cccc(F)c1 to have a lower LogP value.,CC[C@@H](CNC(=O)c1ccccc1F)Oc1cccc(F)c1,3.5522000000000027
+51709,Modify the molecule COC(=O)c1cnn(-c2cccc(C)c2)c1-n1cccc1 to decrease its LogP value.,COC(=O)c1cnn(-c2cccc(C)c2)c1-n1cccc1,2.758020000000001
+60478,Please modify the molecule CCC(CC)N1C(=O)C2(CCCCC2)NC(=O)C1(C)C to increase its LogP value.,CCC(CC)N1C(=O)C2(CCCCC2)NC(=O)C1(C)C,2.6149000000000004
+184887,Please optimize the molecule IC[C@@H]1CC[C@@H]2CCCC[C@@H]2C1 to have a higher LogP value.,IC[C@@H]1CC[C@@H]2CCCC[C@@H]2C1,4.027900000000003
+219974,Modify the molecule O=C(CCn1cnc2ccccc2c1=O)Nc1ccc(OC(F)(F)F)cc1 to decrease its LogP value.,O=C(CCn1cnc2ccccc2c1=O)Nc1ccc(OC(F)(F)F)cc1,3.323900000000001
+212185,Please modify the molecule C[C@@H](C(=O)Nc1ccc(Cl)cc1)n1ncc(-c2ccc(Cl)cc2)nc1=O to increase its LogP value.,C[C@@H](C(=O)Nc1ccc(Cl)cc1)n1ncc(-c2ccc(Cl)cc2)nc1=O,3.8118000000000025
+924,Please modify the molecule O=C(COc1ccc(Br)cc1)NOCc1ccccc1 to increase its LogP value.,O=C(COc1ccc(Br)cc1)NOCc1ccccc1,3.0759000000000007
+32157,Please modify the molecule C[C@@H](NC(=O)[C@@H](C)[NH+]1CCCC1)c1ccccc1 to increase its LogP value.,C[C@@H](NC(=O)[C@@H](C)[NH+]1CCCC1)c1ccccc1,0.9310000000000003
+108690,Please modify the molecule NS(=O)(=O)N1CCc2ccc(NC(=O)[C@H]3C[C@@H]3c3ccccc3)cc21 to increase its LogP value.,NS(=O)(=O)N1CCc2ccc(NC(=O)[C@H]3C[C@@H]3c3ccccc3)cc21,1.9948
+102861,Please modify the molecule CCCn1c(-c2ccc(SC)cc2)nc2c1c(=O)[nH]c(=O)n2Cc1ccccc1 to increase its LogP value.,CCCn1c(-c2ccc(SC)cc2)nc2c1c(=O)[nH]c(=O)n2Cc1ccccc1,3.733500000000002
+61660,Please optimize the molecule Cc1ccc(C)c(CS(=O)(=O)c2ccc([N+](=O)[O-])cc2)c1 to have a lower LogP value.,Cc1ccc(C)c(CS(=O)(=O)c2ccc([N+](=O)[O-])cc2)c1,3.1855400000000014
+141460,Modify the molecule CNS(=O)(=O)c1ccc(NC(=O)/C=C/c2ccc(SC)cc2)cc1 to increase its LogP value.,CNS(=O)(=O)c1ccc(NC(=O)/C=C/c2ccc(SC)cc2)cc1,2.9685000000000015
+36861,Optimize the molecule COC(=O)C(C)(C)[C@H]1CCCN(CN2C(=O)C[C@@](C)(C(C)C)C2=O)C1 to have a higher LogP value.,COC(=O)C(C)(C)[C@H]1CCCN(CN2C(=O)C[C@@](C)(C(C)C)C2=O)C1,2.2763
+193275,Please optimize the molecule O=C(CCN1CCn2c(nnc2C2CC2)C1)NC1CCCC1 to have a lower LogP value.,O=C(CCN1CCn2c(nnc2C2CC2)C1)NC1CCCC1,1.419999999999999
+243223,Modify the molecule COc1ccc2c(cnn2CCC(=O)N2CCN(Cc3cccc(C)c3)CC2)c1 to increase its LogP value.,COc1ccc2c(cnn2CCC(=O)N2CCN(Cc3cccc(C)c3)CC2)c1,3.0878200000000016
+245539,Please optimize the molecule C[C@H]1CCC[C@H](C)N1C(=O)CSc1nnc(-c2ccncc2)n1-c1ccc(Cl)c(Cl)c1 to have a higher LogP value.,C[C@H]1CCC[C@H](C)N1C(=O)CSc1nnc(-c2ccncc2)n1-c1ccc(Cl)c(Cl)c1,5.517700000000005
+213284,Modify the molecule CC1(CNC(=O)c2ncccc2C(F)(F)F)CCC1 to have a lower LogP value.,CC1(CNC(=O)c2ncccc2C(F)(F)F)CCC1,3.020400000000002
+60849,Please optimize the molecule CS(=O)(=O)c1ccc(Cc2nnc(NC(=O)C34CC5CC(CC(C5)C3)C4)o2)cc1 to have a lower LogP value.,CS(=O)(=O)c1ccc(Cc2nnc(NC(=O)C34CC5CC(CC(C5)C3)C4)o2)cc1,3.2188000000000017
+148949,Please optimize the molecule CCc1nc(NC(=O)CCc2nncn2-c2ccccc2)sc1C to have a higher LogP value.,CCc1nc(NC(=O)CCc2nncn2-c2ccccc2)sc1C,3.1659200000000016
+226746,Modify the molecule Cc1ccc(Cl)cc1NC(=O)CCNS(=O)(=O)c1ccc2c(c1)C[C@@H](C)N2C(=O)C1CC1 to decrease its LogP value.,Cc1ccc(Cl)cc1NC(=O)CCNS(=O)(=O)c1ccc2c(c1)C[C@@H](C)N2C(=O)C1CC1,3.6431200000000024
+21869,Please optimize the molecule CCC(=O)N1CC[C@@H](C(=O)N(C[C@@H]2CCCCO2)C(C)C)C1 to have a higher LogP value.,CCC(=O)N1CC[C@@H](C(=O)N(C[C@@H]2CCCCO2)C(C)C)C1,2.0509999999999997
+14937,Please modify the molecule CCCN1CC(=O)N2[C@@H](Cc3c([nH]c4ccccc34)[C@@H]2c2cccc(OC)c2OC)C1=O to decrease its LogP value.,CCCN1CC(=O)N2[C@@H](Cc3c([nH]c4ccccc34)[C@@H]2c2cccc(OC)c2OC)C1=O,3.280000000000002
+245159,Modify the molecule CC(C)N1C(=O)Cc2ccccc2[C@@H]1C(=O)NCc1ccc(N(C)C)cc1 to decrease its LogP value.,CC(C)N1C(=O)Cc2ccccc2[C@@H]1C(=O)NCc1ccc(N(C)C)cc1,2.903200000000002
+213509,Modify the molecule CCCn1c(S(=O)(=O)Cc2csc(-c3ccc(Cl)cc3)n2)n[nH]c1=O to have a higher LogP value.,CCCn1c(S(=O)(=O)Cc2csc(-c3ccc(Cl)cc3)n2)n[nH]c1=O,2.7322000000000006
+112128,Please optimize the molecule CC1(C)CCN(c2nc(C[NH3+])cc3ccccc23)C1 to have a higher LogP value.,CC1(C)CCN(c2nc(C[NH3+])cc3ccccc23)C1,2.212999999999999
+113631,Optimize the molecule CCc1ccccc1N1Cc2ccc(N)cc2C1 to have a lower LogP value.,CCc1ccccc1N1Cc2ccc(N)cc2C1,3.351400000000001
+112706,Please optimize the molecule CCS(=O)(=O)[N-]c1ccc(NC(=O)NC2CCCCC2)cc1C to have a lower LogP value.,CCS(=O)(=O)[N-]c1ccc(NC(=O)NC2CCCCC2)cc1C,3.804120000000003
+221406,Please optimize the molecule CCN(CC)c1nc2sc(C(=O)Nc3cccnc3-n3cccn3)cc2s1 to have a higher LogP value.,CCN(CC)c1nc2sc(C(=O)Nc3cccnc3-n3cccn3)cc2s1,4.0370000000000035
+208255,Please modify the molecule O=S(=O)(Cc1ccccc1Cl)NCC[NH+]1CCN(c2ccccc2F)CC1 to increase its LogP value.,O=S(=O)(Cc1ccccc1Cl)NCC[NH+]1CCN(c2ccccc2F)CC1,1.3036000000000003
+62547,Please optimize the molecule FC(F)(F)c1ccccc1CNCc1cccc(CN2CCOCC2)c1 to have a higher LogP value.,FC(F)(F)c1ccccc1CNCc1cccc(CN2CCOCC2)c1,3.8274000000000026
+87960,Optimize the molecule C[NH+]1CCN(c2ncnc(Nc3ccc(OC(F)(F)F)cc3)c2[N+](=O)[O-])CC1 to have a lower LogP value.,C[NH+]1CCN(c2ncnc(Nc3ccc(OC(F)(F)F)cc3)c2[N+](=O)[O-])CC1,1.3617
+148513,Optimize the molecule Cc1cc(NC(=O)c2cccc3ccccc23)sn1 to have a higher LogP value.,Cc1cc(NC(=O)c2cccc3ccccc23)sn1,3.8570200000000012
+209848,Optimize the molecule Cc1cc(C)n2nc(SCC(=O)c3ccc[nH]3)nc2n1 to have a higher LogP value.,Cc1cc(C)n2nc(SCC(=O)c3ccc[nH]3)nc2n1,2.04424
+147194,Optimize the molecule CC(C)C[C@@H]1NC(=O)C(C)(C)N(Cc2nccs2)C1=O to have a lower LogP value.,CC(C)C[C@@H]1NC(=O)C(C)(C)N(Cc2nccs2)C1=O,1.7947999999999995
+173871,Optimize the molecule CCc1nn(C)cc1NC(=O)c1cc(C)cc(Br)c1O to have a lower LogP value.,CCc1nn(C)cc1NC(=O)c1cc(C)cc(Br)c1O,3.0113200000000018
+206612,Modify the molecule Cc1ccc2c(c1)N(C(=O)c1cc(C(C)C)[nH]n1)C[C@H](C)O2 to decrease its LogP value.,Cc1ccc2c(c1)N(C(=O)c1cc(C(C)C)[nH]n1)C[C@H](C)O2,3.2692200000000007
+227086,Optimize the molecule COc1ccccc1C(=O)NC(=S)N(C)C1CCCCC1 to have a higher LogP value.,COc1ccccc1C(=O)NC(=S)N(C)C1CCCCC1,2.974400000000001
+56973,Please optimize the molecule COC(=O)Cc1n[nH]c2c1[C@@H](c1ccc(OC)c(Br)c1)C(C#N)=C(N)O2 to have a lower LogP value.,COC(=O)Cc1n[nH]c2c1[C@@H](c1ccc(OC)c(Br)c1)C(C#N)=C(N)O2,2.11448
+124827,Modify the molecule COC(=O)[C@H]1CCCCC[C@H]1NC(=O)Nc1ccccc1N(C)C to have a lower LogP value.,COC(=O)[C@H]1CCCCC[C@H]1NC(=O)Nc1ccccc1N(C)C,2.9960000000000013
+62533,Please modify the molecule C[C@@H]1CCC[C@@]([C@H](O)[C@@H]2CCc3cccnc32)([NH+](C)C)C1 to decrease its LogP value.,C[C@@H]1CCC[C@@]([C@H](O)[C@@H]2CCc3cccnc32)([NH+](C)C)C1,1.5656999999999999
+119351,Please optimize the molecule COc1ccc(-c2noc(C[NH2+]C3CCCCC3)n2)cc1 to have a lower LogP value.,COc1ccc(-c2noc(C[NH2+]C3CCCCC3)n2)cc1,2.1413
+36956,Please modify the molecule CCOC(=O)c1nc(Nc2ccsc2C(=O)OC)c2c(C)noc2n1 to decrease its LogP value.,CCOC(=O)c1nc(Nc2ccsc2C(=O)OC)c2c(C)noc2n1,2.6946200000000005
+140907,Please optimize the molecule CC(C)C(=O)N1CCC[C@H]1C(=O)N1CCCCCCC1 to have a lower LogP value.,CC(C)C(=O)N1CCC[C@H]1C(=O)N1CCCCCCC1,2.4261
+154169,Please optimize the molecule CCC1CCC(NC(=O)CNCC(F)(F)F)(C(=O)[O-])CC1 to have a higher LogP value.,CCC1CCC(NC(=O)CNCC(F)(F)F)(C(=O)[O-])CC1,0.3434
+100993,Modify the molecule C[C@@H]1CN(C(=O)c2cc(S(C)(=O)=O)c(Cl)cc2Cl)C[C@@H](C)O1 to have a lower LogP value.,C[C@@H]1CN(C(=O)c2cc(S(C)(=O)=O)c(Cl)cc2Cl)C[C@@H](C)O1,2.646300000000001
+79098,Please modify the molecule COc1ccc(C[NH2+]Cc2cc(F)c(F)c(F)c2)cc1OC to increase its LogP value.,COc1ccc(C[NH2+]Cc2cc(F)c(F)c(F)c2)cc1OC,2.3847000000000005
+188995,Modify the molecule O=C(c1cccnc1)N1CCN(CC2=c3ccccc3=[NH+]C2)CC1 to increase its LogP value.,O=C(c1cccnc1)N1CCN(CC2=c3ccccc3=[NH+]C2)CC1,-1.5958999999999968
+160361,Please modify the molecule COc1cccc(-c2cc(C(=O)NCC#CCOc3cccc4cccnc34)[nH]n2)c1 to increase its LogP value.,COc1cccc(-c2cc(C(=O)NCC#CCOc3cccc4cccnc34)[nH]n2)c1,3.4457000000000013
+146260,Optimize the molecule NS(=O)(=O)c1ccc(CNC(=O)NCCc2cccc(F)c2)cc1 to have a higher LogP value.,NS(=O)(=O)c1ccc(CNC(=O)NCCc2cccc(F)c2)cc1,1.5149999999999997
+11643,Modify the molecule COc1ccc(NC(=O)c2nnc(C(=O)NCc3ccc(N(C)C)cc3)s2)cc1 to have a lower LogP value.,COc1ccc(NC(=O)c2nnc(C(=O)NCc3ccc(N(C)C)cc3)s2)cc1,2.795000000000001
+171607,Please optimize the molecule Cc1nn(-c2ccccc2)c(CN2C(=O)N[C@@]3(CCSC3)C2=O)c1C#N to have a lower LogP value.,Cc1nn(-c2ccccc2)c(CN2C(=O)N[C@@]3(CCSC3)C2=O)c1C#N,1.9799000000000002
+213266,Please modify the molecule CCCC(CCC)CC(=O)Nc1ccc2oc(=O)n(C)c2c1 to decrease its LogP value.,CCCC(CCC)CC(=O)Nc1ccc2oc(=O)n(C)c2c1,3.6765000000000025
+88864,Modify the molecule CC[C@H](CS)COc1ccc(F)cc1 to have a lower LogP value.,CC[C@H](CS)COc1ccc(F)cc1,3.1605000000000016
+240889,Please optimize the molecule CC1(C)CC(=O)C2=C(C1)Nc1nc(Cc3ccccc3)nn1[C@@H]2c1ccc2c(c1)OCCCO2 to have a higher LogP value.,CC1(C)CC(=O)C2=C(C1)Nc1nc(Cc3ccccc3)nn1[C@@H]2c1ccc2c(c1)OCCCO2,4.688300000000004
+107434,Please optimize the molecule CN(C(=O)c1ccc2ccc(Cl)cc2n1)c1ccc(F)c(F)c1 to have a lower LogP value.,CN(C(=O)c1ccc2ccc(Cl)cc2n1)c1ccc(F)c(F)c1,4.443000000000001
+125041,Please optimize the molecule C[C@H]1CN(c2nc([O-])c3c(n2)C[NH+](Cc2ccc(N4CCOCC4)cc2)CC3)C[C@@H](C)O1 to have a higher LogP value.,C[C@H]1CN(c2nc([O-])c3c(n2)C[NH+](Cc2ccc(N4CCOCC4)cc2)CC3)C[C@@H](C)O1,0.1416000000000044
+111456,Modify the molecule COC(=O)C[C@H](NS(=O)(=O)c1c[nH]c2nccc(Cl)c12)c1ccccc1 to have a lower LogP value.,COC(=O)C[C@H](NS(=O)(=O)c1c[nH]c2nccc(Cl)c12)c1ccccc1,2.7990000000000013
+74813,Modify the molecule CC[C@H](COC)N[C@H]1CC[NH+](C)[C@@H]1c1ccc(Cl)cc1 to decrease its LogP value.,CC[C@H](COC)N[C@H]1CC[NH+](C)[C@@H]1c1ccc(Cl)cc1,1.6827000000000003
+211870,Please optimize the molecule Cc1nc(-c2ccccc2)sc1CNC(=O)NCC(C)(C)[NH+](C)C to have a higher LogP value.,Cc1nc(-c2ccccc2)sc1CNC(=O)NCC(C)(C)[NH+](C)C,1.84082
+199553,Modify the molecule C/C(=N\NC(=O)CNc1cccc(Br)c1)c1ccc(Br)cc1 to increase its LogP value.,C/C(=N\NC(=O)CNc1cccc(Br)c1)c1ccc(Br)cc1,4.163900000000003
+174809,Modify the molecule C[C@H](NC(=O)Nc1ccc(C(N)=O)cc1F)c1ccc(Cl)cc1 to increase its LogP value.,C[C@H](NC(=O)Nc1ccc(C(N)=O)cc1F)c1ccc(Cl)cc1,3.460700000000001
+193407,Optimize the molecule O=C(COc1ccccc1F)Nc1cccc(S(=O)(=O)N2CCCC2)c1 to have a higher LogP value.,O=C(COc1ccccc1F)Nc1cccc(S(=O)(=O)N2CCCC2)c1,2.627700000000001
+110747,Modify the molecule Cc1cc(NCCCc2c(C)n[nH]c2C)n2nc(C)cc2n1 to increase its LogP value.,Cc1cc(NCCCc2c(C)n[nH]c2C)n2nc(C)cc2n1,2.730780000000001
+242599,Please optimize the molecule Cc1ccc(N2C[C@@H](C(=O)O[C@H](C)C(=O)c3ccccc3)CC2=O)cc1 to have a higher LogP value.,Cc1ccc(N2C[C@@H](C(=O)O[C@H](C)C(=O)c3ccccc3)CC2=O)cc1,3.1625200000000016
+67336,Optimize the molecule Cc1ccc(C(=O)c2oc3ccccc3c2NC(=O)c2cc3occc3n2C)cc1 to have a lower LogP value.,Cc1ccc(C(=O)c2oc3ccccc3c2NC(=O)c2cc3occc3n2C)cc1,5.309220000000003
+75641,Optimize the molecule O=C1CN(C(=O)c2ccccn2)C[C@@H](OCc2cccnc2)CN1CC1CCOCC1 to have a higher LogP value.,O=C1CN(C(=O)c2ccccn2)C[C@@H](OCc2cccnc2)CN1CC1CCOCC1,1.7730000000000001
+141246,Optimize the molecule Cc1nc2ccc(N[C@@H](C)C[C@H]3CCCCC[NH2+]3)cc2s1 to have a higher LogP value.,Cc1nc2ccc(N[C@@H](C)C[C@H]3CCCCC[NH2+]3)cc2s1,3.3012200000000007
+133165,Please optimize the molecule COCC[NH+]1CCC[C@@H](CN(C)c2nc3c(s2)c(C)nn3C)C1 to have a higher LogP value.,COCC[NH+]1CCC[C@@H](CN(C)c2nc3c(s2)c(C)nn3C)C1,0.7157200000000008
+118472,Please modify the molecule C[C@@H]1OCC[C@H]1C(=O)N1CCCC[C@@H]1CCl to increase its LogP value.,C[C@@H]1OCC[C@H]1C(=O)N1CCCC[C@@H]1CCl,2.0313
+159314,Modify the molecule CCN(CC)c1ccc(/C=C(/C#N)c2nc3cccc(C)c3[nH]2)cc1 to have a lower LogP value.,CCN(CC)c1ccc(/C=C(/C#N)c2nc3cccc(C)c3[nH]2)cc1,4.781700000000003
+110043,Modify the molecule C[C@H]1CCC[C@@H](C[NH2+]CC(C)(C)C[C@@H](C)O)C1 to decrease its LogP value.,C[C@H]1CCC[C@@H](C[NH2+]CC(C)(C)C[C@@H](C)O)C1,2.1731999999999996
+217825,Modify the molecule O=[N+]([O-])c1ccc(CSc2nc3cc(Cl)ccc3o2)cc1 to increase its LogP value.,O=[N+]([O-])c1ccc(CSc2nc3cc(Cl)ccc3o2)cc1,4.681700000000003
+212286,Modify the molecule Cc1cccc2c(CCNC(=O)N[C@@H](CO)c3ccccc3F)c[nH]c12 to decrease its LogP value.,Cc1cccc2c(CCNC(=O)N[C@@H](CO)c3ccccc3F)c[nH]c12,3.1907200000000007
+196456,Modify the molecule CCCc1noc(Cn2nc(C(C)(C)C)ccc2=O)n1 to increase its LogP value.,CCCc1noc(Cn2nc(C(C)(C)C)ccc2=O)n1,1.9246
+239602,Modify the molecule COc1ccc(NC(=O)c2nnc([C@@H]3CCCN(C(=O)Nc4cc(C)ccc4C)C3)s2)cc1 to have a higher LogP value.,COc1ccc(NC(=O)c2nnc([C@@H]3CCCN(C(=O)Nc4cc(C)ccc4C)C3)s2)cc1,4.827340000000004
+119245,Optimize the molecule CNc1cc(COc2ccccc2OC)ccc1[N+](=O)[O-] to have a lower LogP value.,CNc1cc(COc2ccccc2OC)ccc1[N+](=O)[O-],3.2241000000000017
+207601,Please modify the molecule CC[NH+](CC)CCCn1c([C@@H](C)O)nc2ccc(Cl)cc21 to increase its LogP value.,CC[NH+](CC)CCCn1c([C@@H](C)O)nc2ccc(Cl)cc21,2.0578000000000003
+83379,Modify the molecule O=C(NCc1ccco1)[C@H]1C[NH+]2CC[C@@H]1C[C@@H]2Cn1cc(C2(O)CCCC2)nn1 to have a lower LogP value.,O=C(NCc1ccco1)[C@H]1C[NH+]2CC[C@@H]1C[C@@H]2Cn1cc(C2(O)CCCC2)nn1,0.24240000000000061
+145036,Please optimize the molecule CC[C@H](NC(=O)NCc1ccc(S(=O)(=O)N2CCCCC2)cc1)c1ccc(Br)cc1 to have a higher LogP value.,CC[C@H](NC(=O)NCc1ccc(S(=O)(=O)N2CCCCC2)cc1)c1ccc(Br)cc1,4.574200000000005
+31091,Modify the molecule CCCS(=O)(=O)N1CCC[C@@H]1C(=O)Oc1ccc(C)c(C)c1 to decrease its LogP value.,CCCS(=O)(=O)N1CCC[C@@H]1C(=O)Oc1ccc(C)c(C)c1,2.4130400000000005
+137925,Modify the molecule Cn1cc([C@H](O)CNC(=O)Nc2ccc([N+](=O)[O-])cc2)cn1 to decrease its LogP value.,Cn1cc([C@H](O)CNC(=O)Nc2ccc([N+](=O)[O-])cc2)cn1,1.1834
+157687,Please optimize the molecule CCCNC(=O)[C@H](C)NC(=O)c1ccc(-n2cccc2)cc1 to have a higher LogP value.,CCCNC(=O)[C@H](C)NC(=O)c1ccc(-n2cccc2)cc1,2.1217999999999995
+85605,Modify the molecule Cc1cc(C)c(NNC(=O)c2coc(-c3ccccc3)n2)c(C)c1 to have a lower LogP value.,Cc1cc(C)c(NNC(=O)c2coc(-c3ccccc3)n2)c(C)c1,4.023760000000002
+196905,Modify the molecule CN(CC(=O)Nc1ccc(F)c(F)c1F)C(=O)c1cnn(C)c1 to have a lower LogP value.,CN(CC(=O)Nc1ccc(F)c(F)c1F)C(=O)c1cnn(C)c1,1.5480999999999998
+202349,Optimize the molecule COc1ccc(C(=O)NC(=S)Nc2ccc(-c3ccc(CO)o3)c(C)c2)cc1Cl to have a higher LogP value.,COc1ccc(C(=O)NC(=S)Nc2ccc(-c3ccc(CO)o3)c(C)c2)cc1Cl,4.536120000000003
+20437,Modify the molecule Cc1cccnc1C[NH+]1CCN(Cc2ccc(Cl)cc2)CC1 to have a higher LogP value.,Cc1cccnc1C[NH+]1CCN(Cc2ccc(Cl)cc2)CC1,1.9441200000000003
+60979,Modify the molecule Cc1ccsc1CNC(=O)NCc1ccc(NC(=O)NC(C)C)cc1 to increase its LogP value.,Cc1ccsc1CNC(=O)NCc1ccc(NC(=O)NC(C)C)cc1,3.585820000000002
+68920,Optimize the molecule ClC1=CC2=CC=N[C@@H]2C(Cl)=C1 to have a lower LogP value.,ClC1=CC2=CC=N[C@@H]2C(Cl)=C1,2.6248000000000005
+60484,Optimize the molecule C[C@@H]1CCc2sc(C(=O)NNC(=O)C3C[C@@H](C)O[C@H](C)C3)cc2C1 to have a higher LogP value.,C[C@@H]1CCc2sc(C(=O)NNC(=O)C3C[C@@H](C)O[C@H](C)C3)cc2C1,2.8375000000000012
+62950,Please optimize the molecule CC[C@@H](C(=O)N1CCC(n2nnc3c(=O)nc(C)[nH]c32)CC1)c1ccccc1 to have a higher LogP value.,CC[C@@H](C(=O)N1CCC(n2nnc3c(=O)nc(C)[nH]c32)CC1)c1ccccc1,2.180319999999999
+182952,Optimize the molecule COC(=O)c1ccccc1N(C)S(=O)(=O)c1ccc(C(F)(F)F)cc1 to have a higher LogP value.,COC(=O)c1ccccc1N(C)S(=O)(=O)c1ccc(C(F)(F)F)cc1,3.3171000000000017
+162718,Please optimize the molecule CC1=C2[C@H](c3ccc(C(F)(F)F)cc3)CC(=O)N[C@@H]2N(c2ccc([O-])nn2)N1 to have a lower LogP value.,CC1=C2[C@H](c3ccc(C(F)(F)F)cc3)CC(=O)N[C@@H]2N(c2ccc([O-])nn2)N1,1.797399999999999
+173103,Please optimize the molecule CC(C)Cc1noc(C[NH+](C)[C@H](C)C(=O)Nc2nccs2)n1 to have a higher LogP value.,CC(C)Cc1noc(C[NH+](C)[C@H](C)C(=O)Nc2nccs2)n1,0.7664999999999993
+105887,Modify the molecule CCCn1c(=O)c2cc(Cl)ccc2n2c(SCC(=O)Nc3ccc4c(c3)OCCO4)nnc12 to have a higher LogP value.,CCCn1c(=O)c2cc(Cl)ccc2n2c(SCC(=O)Nc3ccc4c(c3)OCCO4)nnc12,3.6096000000000013
+112944,Modify the molecule C[C@@H]1C[C@@H](N(C)C(=O)c2cc(CCc3ccccc3)ccc2O)CC[NH+]1C to increase its LogP value.,C[C@@H]1C[C@@H](N(C)C(=O)c2cc(CCc3ccccc3)ccc2O)CC[NH+]1C,2.3150000000000004
+75564,Modify the molecule O=C(NCCC(=O)N1CCN(Cc2cccc3cccnc23)CC1)c1ccc(F)cc1F to have a lower LogP value.,O=C(NCCC(=O)N1CCN(Cc2cccc3cccnc23)CC1)c1ccc(F)cc1F,2.9773000000000014
+242924,Please optimize the molecule CC[C@H]1CCCC[C@@H]1NC(=O)C(=O)Nc1cccc(OC(F)(F)F)c1 to have a lower LogP value.,CC[C@H]1CCCC[C@@H]1NC(=O)C(=O)Nc1cccc(OC(F)(F)F)c1,3.6087000000000016
+239164,Modify the molecule COCCn1c(C)cc(CN2CCO[C@H](c3cccc(OC)c3)C2)c1C to decrease its LogP value.,COCCn1c(C)cc(CN2CCO[C@H](c3cccc(OC)c3)C2)c1C,3.333440000000002
+112497,Modify the molecule CCOC(=O)c1c(NC(=O)C2CCCCC2)sc2c1CCN(Cc1ccccc1)C2 to increase its LogP value.,CCOC(=O)c1c(NC(=O)C2CCCCC2)sc2c1CCN(Cc1ccccc1)C2,5.001900000000005
+77537,Please optimize the molecule COc1cccc(NC(=O)[C@H](C)[NH+](C)CC(=O)N2CCOCC2)c1 to have a higher LogP value.,COc1cccc(NC(=O)[C@H](C)[NH+](C)CC(=O)N2CCOCC2)c1,-0.6042999999999976
+120444,Please modify the molecule CN(CC(=O)Nc1c(Cl)cccc1Cl)S(=O)(=O)c1ccc(C#N)cc1 to increase its LogP value.,CN(CC(=O)Nc1c(Cl)cccc1Cl)S(=O)(=O)c1ccc(C#N)cc1,3.1242800000000006
+32449,Optimize the molecule Cc1ccc(CC(=O)N2CCC[C@H](N3CCNC3=O)C2)cc1O to have a lower LogP value.,Cc1ccc(CC(=O)N2CCC[C@H](N3CCNC3=O)C2)cc1O,1.2593199999999998
+10459,Please optimize the molecule COC(=O)C1CCN(C(=O)c2cc(C3CC3)nc3c(C)cc(C)cc23)CC1 to have a lower LogP value.,COC(=O)C1CCN(C(=O)c2cc(C3CC3)nc3c(C)cc(C)cc23)CC1,3.754240000000003
+93433,Optimize the molecule C[C@H]1CC(C)(C)C[C@](CO)([NH2+]Cc2nnc(C(C)(C)C)o2)C1 to have a lower LogP value.,C[C@H]1CC(C)(C)C[C@](CO)([NH2+]Cc2nnc(C(C)(C)C)o2)C1,2.0078
+161702,Modify the molecule Cc1csc(CNC(=O)c2ccccc2SCc2csc(C)n2)n1 to have a higher LogP value.,Cc1csc(CNC(=O)c2ccccc2SCc2csc(C)n2)n1,4.438740000000004
+233482,Optimize the molecule CC(C)C[NH2+]CC[C@](C)(O)Cc1cc(F)cc(Br)c1 to have a higher LogP value.,CC(C)C[NH2+]CC[C@](C)(O)Cc1cc(F)cc(Br)c1,2.491200000000001
+180586,Please optimize the molecule COc1ccccc1O[C@@H](C)CNC(=O)c1cc(C)n(-c2ccccc2)n1 to have a lower LogP value.,COc1ccccc1O[C@@H](C)CNC(=O)c1cc(C)n(-c2ccccc2)n1,3.3866200000000015
+31065,Optimize the molecule CC(C)(C)c1ccc(NC(=O)CN2C(=O)[C@H]3C[C@H]3C2=O)cc1 to have a lower LogP value.,CC(C)(C)c1ccc(NC(=O)CN2C(=O)[C@H]3C[C@H]3C2=O)cc1,1.9275
+154400,Modify the molecule CCC[NH2+][C@@H](c1ccc(Cl)c(Cl)c1)[C@H]1CN(CC)CCO1 to decrease its LogP value.,CCC[NH2+][C@@H](c1ccc(Cl)c(Cl)c1)[C@H]1CN(CC)CCO1,2.728600000000001
+50221,Please modify the molecule C[NH2+][C@]1(C(=O)OC)CCC[C@H](Oc2ccc(F)cc2)C1 to decrease its LogP value.,C[NH2+][C@]1(C(=O)OC)CCC[C@H](Oc2ccc(F)cc2)C1,1.2520999999999993
+163985,Please optimize the molecule O=Cc1ccc(OC[C@H]2CCOC2)cn1 to have a higher LogP value.,O=Cc1ccc(OC[C@H]2CCOC2)cn1,1.3094000000000001
+121698,Please optimize the molecule CC[NH2+][C@@H](C)c1ccnc(N(C)CCO)c1 to have a higher LogP value.,CC[NH2+][C@@H](C)c1ccnc(N(C)CCO)c1,0.15440000000000015
+57438,Modify the molecule Cc1cc2c(cc1C)O[C@@H](C(=O)Nc1ccc(Br)cn1)C2 to increase its LogP value.,Cc1cc2c(cc1C)O[C@@H](C(=O)Nc1ccc(Br)cn1)C2,3.4031400000000014
+131696,Modify the molecule CC[C@H](C)[C@@H](CCl)Cc1cccc(F)c1 to have a higher LogP value.,CC[C@H](C)[C@@H](CCl)Cc1cccc(F)c1,4.269300000000004
+216188,Please optimize the molecule C[C@@H](c1cccc([N+](=O)[O-])c1)N(C)C(=O)[C@H]1CC(=O)N(C)C1 to have a lower LogP value.,C[C@@H](c1cccc([N+](=O)[O-])c1)N(C)C(=O)[C@H]1CC(=O)N(C)C1,1.5924999999999998
+155456,Modify the molecule Cc1ccc(-c2nnco2)cc1NC(=O)N1CCO[C@@H](c2ccccc2)C1 to have a higher LogP value.,Cc1ccc(-c2nnco2)cc1NC(=O)N1CCO[C@@H](c2ccccc2)C1,3.650420000000002
+167442,Optimize the molecule CC[C@H](C)NC(=O)NC1[C@@H](C)CCC[C@H]1C to have a lower LogP value.,CC[C@H](C)NC(=O)NC1[C@@H](C)CCC[C@H]1C,2.908800000000001
+53704,Optimize the molecule CCCN(c1cccc(Cl)c1/C=C/C(=O)[O-])C1CC1 to have a higher LogP value.,CCCN(c1cccc(Cl)c1/C=C/C(=O)[O-])C1CC1,2.4819000000000004
+182268,Please optimize the molecule CC(C)Cn1nnnc1SCC(=O)c1ccc(Cl)s1 to have a higher LogP value.,CC(C)Cn1nnnc1SCC(=O)c1ccc(Cl)s1,3.019000000000002
+192897,Please optimize the molecule CC(C)[C@@H]1CCC[C@@H]([NH+](C)C2CCC([NH3+])CC2)CC1 to have a higher LogP value.,CC(C)[C@@H]1CCC[C@@H]([NH+](C)C2CCC([NH3+])CC2)CC1,1.659100000000001
+98881,Optimize the molecule C[NH+](C)[C@H]1CCN(C(=O)c2ccncc2/C=C/C(=O)[O-])C1 to have a higher LogP value.,C[NH+](C)[C@H]1CCN(C(=O)c2ccncc2/C=C/C(=O)[O-])C1,-1.7962999999999956
+241283,Modify the molecule Cc1nc(CC(=O)N[C@H](c2ccccc2)c2ccc(Cl)cc2)cs1 to decrease its LogP value.,Cc1nc(CC(=O)N[C@H](c2ccccc2)c2ccc(Cl)cc2)cs1,4.553220000000003
+92205,Modify the molecule C#CCN1CCN(C(=O)CNc2cccc(C(=O)NCCO)c2C)CC1 to have a higher LogP value.,C#CCN1CCN(C(=O)CNc2cccc(C(=O)NCCO)c2C)CC1,-0.09357999999999866
+153108,Optimize the molecule C#Cc1cccc(NCC(=O)Nc2ccc3c(c2)OCO3)c1 to have a lower LogP value.,C#Cc1cccc(NCC(=O)Nc2ccc3c(c2)OCO3)c1,2.4472000000000005
+137262,Please modify the molecule COCCNC(=O)[C@H](C)Sc1ncn(-c2ccccc2)n1 to increase its LogP value.,COCCNC(=O)[C@H](C)Sc1ncn(-c2ccccc2)n1,1.5104999999999995
+226700,Please optimize the molecule CC(C)c1nc(N2CCC(C)(C)CC2)sc1C=O to have a higher LogP value.,CC(C)c1nc(N2CCC(C)(C)CC2)sc1C=O,3.7054000000000027
+114912,Modify the molecule CCO[C@H](CC)C(=O)Nc1cccc(-c2ncc(C)o2)c1 to increase its LogP value.,CCO[C@H](CC)C(=O)Nc1cccc(-c2ncc(C)o2)c1,3.403620000000002
+25675,Please optimize the molecule CON(C)C(=O)[C@H]1CCCCN1C(=O)OC(C)(C)C to have a higher LogP value.,CON(C)C(=O)[C@H]1CCCCN1C(=O)OC(C)(C)C,1.7957999999999998
+184456,Modify the molecule Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1C(=O)NCC(C)(C)O to have a lower LogP value.,Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1C(=O)NCC(C)(C)O,3.6380200000000023
+246757,Please modify the molecule O=C(CSc1nnc(-c2ccncc2)n1-n1cccc1)Nc1cccc(C(F)(F)F)c1 to decrease its LogP value.,O=C(CSc1nnc(-c2ccncc2)n1-n1cccc1)Nc1cccc(C(F)(F)F)c1,4.202600000000003
+59402,Modify the molecule CCc1noc(CC)c1CC(=O)N1[C@@H](C)C[C@H](c2ccccc2)[C@@H]1C to decrease its LogP value.,CCc1noc(CC)c1CC(=O)N1[C@@H](C)C[C@H](c2ccccc2)[C@@H]1C,4.135000000000003
+12452,Please optimize the molecule CN(CCc1ccccn1)[C@@H]1CCC[C@H]([NH3+])C1 to have a lower LogP value.,CN(CCc1ccccn1)[C@@H]1CCC[C@H]([NH3+])C1,1.109
+95087,Optimize the molecule O=C(NCCC(=O)N1CCCC1)N[C@H]1CCO[C@@H]1c1ccccc1 to have a lower LogP value.,O=C(NCCC(=O)N1CCCC1)N[C@H]1CCO[C@@H]1c1ccccc1,1.8282999999999998
+76968,Optimize the molecule C[NH2+][C@H](c1ccc2c(c1)CCCC(=O)N2)c1cscc1C to have a higher LogP value.,C[NH2+][C@H](c1ccc2c(c1)CCCC(=O)N2)c1cscc1C,2.613920000000001
+195597,Please modify the molecule CCOCC(=O)N1CC[C@H]2CC[C@@H](C1)[NH+]2C to increase its LogP value.,CCOCC(=O)N1CC[C@H]2CC[C@@H](C1)[NH+]2C,-0.6990999999999972
+195503,Modify the molecule COc1ccc(N2C(=O)CN(CCc3ccccc3)[C@H]3CS(=O)(=O)C[C@H]32)cc1 to increase its LogP value.,COc1ccc(N2C(=O)CN(CCc3ccccc3)[C@H]3CS(=O)(=O)C[C@H]32)cc1,1.7520999999999998
+203465,Please modify the molecule C[C@@H]1CCCN(C(=O)C2CCN(Cn3nc(Nc4ccccc4F)sc3=S)CC2)C1 to increase its LogP value.,C[C@@H]1CCCN(C(=O)C2CCN(Cn3nc(Nc4ccccc4F)sc3=S)CC2)C1,4.484790000000004
+173938,Modify the molecule CC[NH+](CC)CCN1C(=O)c2oc3ccc(F)cc3c(=O)c2[C@H]1c1cccc(Cl)c1 to decrease its LogP value.,CC[NH+](CC)CCN1C(=O)c2oc3ccc(F)cc3c(=O)c2[C@H]1c1cccc(Cl)c1,3.0554000000000014
+245270,Modify the molecule Cc1ccccc1-c1nc(CS(=O)(=O)CC(=O)N[C@@H]2CCCC[C@@H]2C)c(C)o1 to have a lower LogP value.,Cc1ccccc1-c1nc(CS(=O)(=O)CC(=O)N[C@@H]2CCCC[C@@H]2C)c(C)o1,3.5681400000000023
+28043,Modify the molecule O=C(NN1CCCCC1)/C(=C/c1c([O-])on[n+]1-c1ccccc1)NC(=O)c1ccccc1 to have a lower LogP value.,O=C(NN1CCCCC1)/C(=C/c1c([O-])on[n+]1-c1ccccc1)NC(=O)c1ccccc1,1.3128999999999993
+72707,Optimize the molecule C[C@H]1OCC[C@H]1C(=O)N1CCC(=Cc2cc(Cl)ccc2Cl)CC1 to have a higher LogP value.,C[C@H]1OCC[C@H]1C(=O)N1CCC(=Cc2cc(Cl)ccc2Cl)CC1,4.424200000000004
+126515,Please modify the molecule O=C(CNc1cc(S(=O)(=O)N2CCOCC2)ccc1N1CCCCC1)N1CCc2ccccc21 to decrease its LogP value.,O=C(CNc1cc(S(=O)(=O)N2CCOCC2)ccc1N1CCCCC1)N1CCc2ccccc21,2.6990000000000007
+108588,Modify the molecule C[C@H](NC(=O)NCCSc1ccc(Cl)cc1)c1ccc(S(C)(=O)=O)cc1 to have a higher LogP value.,C[C@H](NC(=O)NCCSc1ccc(Cl)cc1)c1ccc(S(C)(=O)=O)cc1,3.8960000000000035
+218077,Modify the molecule Cc1c2c(=O)n(C)[nH]c2cc(=O)n1-c1ccc(Oc2ccccc2)cc1 to have a lower LogP value.,Cc1c2c(=O)n(C)[nH]c2cc(=O)n1-c1ccc(Oc2ccccc2)cc1,3.1182200000000018
+113413,Optimize the molecule Cc1ccc(-c2nc(CC[NH3+])n[nH]2)cc1 to have a higher LogP value.,Cc1ccc(-c2nc(CC[NH3+])n[nH]2)cc1,0.5645199999999997
+33076,Please modify the molecule CC(C)N(C(=O)C[NH+]1CC[C@H]2CC[C@@H](C1)N2C)C(C)C to decrease its LogP value.,CC(C)N(C(=O)C[NH+]1CC[C@H]2CC[C@@H](C1)N2C)C(C)C,0.3832000000000022
+62213,Modify the molecule O=C(CNC(=O)c1cnn2cc(Br)cnc12)Nc1cccnc1 to decrease its LogP value.,O=C(CNC(=O)c1cnn2cc(Br)cnc12)Nc1cccnc1,1.2552999999999996
+99603,Optimize the molecule Brc1ccc(-c2cn3ccccc3n2)s1 to have a lower LogP value.,Brc1ccc(-c2cn3ccccc3n2)s1,3.8253000000000013
+124501,Modify the molecule C[C@@H]1CCN(C(=O)OC(C)(C)C)c2nc(CCO)ccc21 to decrease its LogP value.,C[C@@H]1CCN(C(=O)OC(C)(C)C)c2nc(CCO)ccc21,2.8651000000000018
+56724,Optimize the molecule c1cc(-c2cscn2)cc(N2CCC([NH2+]CCc3cccs3)CC2)c1 to have a higher LogP value.,c1cc(-c2cscn2)cc(N2CCC([NH2+]CCc3cccs3)CC2)c1,3.6465000000000023
+97732,Optimize the molecule COc1ccc(N2CSC3=C(C#N)[C@@H](c4c(F)cccc4Cl)CC(=O)N3C2)c(OC)c1 to have a lower LogP value.,COc1ccc(N2CSC3=C(C#N)[C@@H](c4c(F)cccc4Cl)CC(=O)N3C2)c(OC)c1,4.715780000000004
+71216,Optimize the molecule COc1cc(CCC(=O)Oc2cc(C)c3c(c2)O/C(=C\c2ccccc2Br)C3=O)on1 to have a higher LogP value.,COc1cc(CCC(=O)Oc2cc(C)c3c(c2)O/C(=C\c2ccccc2Br)C3=O)on1,4.908520000000003
+28356,Modify the molecule COc1ccc(OC)c(NC(=O)[C@@H](C)OC(=O)c2ccc(F)cc2)c1 to decrease its LogP value.,COc1ccc(OC)c(NC(=O)[C@@H](C)OC(=O)c2ccc(F)cc2)c1,3.0269000000000013
+169647,Please optimize the molecule CC[NH2+][C@@H]1c2cc(OC)ccc2CC[C@@H]1S(C)(=O)=O to have a higher LogP value.,CC[NH2+][C@@H]1c2cc(OC)ccc2CC[C@@H]1S(C)(=O)=O,0.6789999999999996
+151245,Please optimize the molecule CC(=O)c1ccc(NC(=O)N[C@@H]2CCC[C@@H]2C)cc1C to have a higher LogP value.,CC(=O)c1ccc(NC(=O)N[C@@H]2CCC[C@@H]2C)cc1C,3.5077200000000026
+147686,Modify the molecule C[C@@H]1C[C@]2(CC[NH2+]C[C@@H]2c2cccc(F)c2)CCO1 to decrease its LogP value.,C[C@@H]1C[C@]2(CC[NH2+]C[C@@H]2c2cccc(F)c2)CCO1,2.0617
+191157,Please modify the molecule CCC[C@@H](O)c1ccn(CCN2CCOCC2)c1 to increase its LogP value.,CCC[C@@H](O)c1ccn(CCN2CCOCC2)c1,1.6538000000000002
+83864,Please modify the molecule O=C(/C=C/NCc1ccc(Cl)cc1)c1cc(Cl)sc1Cl to increase its LogP value.,O=C(/C=C/NCc1ccc(Cl)cc1)c1cc(Cl)sc1Cl,5.194500000000002
+151098,Modify the molecule Cc1nc2ccc(Cl)cc2cc1C(=O)N(C)Cc1ccc([C@@H]2C[C@H]2C)o1 to have a lower LogP value.,Cc1nc2ccc(Cl)cc2cc1C(=O)N(C)Cc1ccc([C@@H]2C[C@H]2C)o1,5.185220000000005
+249034,Modify the molecule CCN(c1[nH+]cnc(N(C)C)c1N)c1cccc2ccccc12 to have a lower LogP value.,CCN(c1[nH+]cnc(N(C)C)c1N)c1cccc2ccccc12,2.8551
+150225,Optimize the molecule COC(=O)CCC[C@@H]([NH3+])c1cc(C)c(Br)s1 to have a lower LogP value.,COC(=O)CCC[C@@H]([NH3+])c1cc(C)c(Br)s1,2.4453200000000006
+163262,Optimize the molecule Cc1ccccc1OCCN(C)C(=O)N[C@@H]1CC[C@H]([NH+](C)C)C1 to have a lower LogP value.,Cc1ccccc1OCCN(C)C(=O)N[C@@H]1CC[C@H]([NH+](C)C)C1,1.0808200000000006
+70317,Please optimize the molecule COC(=O)[C@@H]1C(=O)[C@@]2(Cc3c(ccc4ccccc34)N(Cc3ccc(OC)cc3)C2)C(=O)CC1(C)C to have a higher LogP value.,COC(=O)[C@@H]1C(=O)[C@@]2(Cc3c(ccc4ccccc34)N(Cc3ccc(OC)cc3)C2)C(=O)CC1(C)C,4.754800000000005
+232496,Please modify the molecule Cc1ccc2sc(N(CCN3CCOCC3)C(=O)c3cc([N+](=O)[O-])ccc3Cl)nc2c1C to increase its LogP value.,Cc1ccc2sc(N(CCN3CCOCC3)C(=O)c3cc([N+](=O)[O-])ccc3Cl)nc2c1C,4.453740000000003
+3317,Please modify the molecule C[C@@H]([NH2+]C[C@]1(C)CCCO1)c1ccc2c(c1)CCC2 to decrease its LogP value.,C[C@@H]([NH2+]C[C@]1(C)CCCO1)c1ccc2c(c1)CCC2,2.3688000000000002
+36090,Modify the molecule Cc1cc(CNC(=O)N[C@@](C)(CO)C2CCCCC2)no1 to decrease its LogP value.,Cc1cc(CNC(=O)N[C@@](C)(CO)C2CCCCC2)no1,2.1135199999999994
+156639,Please modify the molecule CC(C)c1csc([C@@]2(N)CCCS[C@@H]2C)n1 to decrease its LogP value.,CC(C)c1csc([C@@]2(N)CCCS[C@@H]2C)n1,3.336000000000002
+219319,Optimize the molecule CN1C[C@H](NC(=O)c2cc(Cl)ccc2O)CCC1=O to have a lower LogP value.,CN1C[C@H](NC(=O)c2cc(Cl)ccc2O)CCC1=O,1.3961999999999997
+159017,Please modify the molecule Cc1ccc(S(=O)(=O)/N=C2\N=c3ccccc3=[NH+][C@@H]2Nc2ccc3c(c2)OCCO3)c(C)c1 to decrease its LogP value.,Cc1ccc(S(=O)(=O)/N=C2\N=c3ccccc3=[NH+][C@@H]2Nc2ccc3c(c2)OCCO3)c(C)c1,0.6336400000000002
+47445,Optimize the molecule CSCc1nnc(SCc2ccccn2)o1 to have a higher LogP value.,CSCc1nnc(SCc2ccccn2)o1,2.6199000000000003
+42784,Please optimize the molecule CCC(C)(C)C1CCC(NS(=O)(=O)c2ccc(S(C)(=O)=O)cc2)CC1 to have a lower LogP value.,CCC(C)(C)C1CCC(NS(=O)(=O)c2ccc(S(C)(=O)=O)cc2)CC1,3.363400000000002
+156239,Please optimize the molecule Cc1ccc(NC(=O)/C=C/c2ccc([N+](=O)[O-])cc2)c(Cl)c1 to have a higher LogP value.,Cc1ccc(NC(=O)/C=C/c2ccc([N+](=O)[O-])cc2)c(Cl)c1,4.208520000000003
+191612,Please modify the molecule COCC1CCN(C(=O)c2nn(-c3ccc(F)cc3)cc2[O-])CC1 to increase its LogP value.,COCC1CCN(C(=O)c2nn(-c3ccc(F)cc3)cc2[O-])CC1,1.5836000000000001
+62140,Modify the molecule O=C(CCn1cncn1)N1CCC[C@H](c2[nH+]ccn2Cc2ccccc2)C1 to have a higher LogP value.,O=C(CCn1cncn1)N1CCC[C@H](c2[nH+]ccn2Cc2ccccc2)C1,1.738299999999999
+195088,Please optimize the molecule O=C(NCCc1cccs1)c1cn[nH]c1-c1ccc([N+](=O)[O-])cc1 to have a higher LogP value.,O=C(NCCc1cccs1)c1cn[nH]c1-c1ccc([N+](=O)[O-])cc1,3.0189000000000012
+28812,Optimize the molecule CCc1nn(C)c(OC)c1CNC(=O)c1ccccc1[S@](=O)CC to have a higher LogP value.,CCc1nn(C)c(OC)c1CNC(=O)c1ccccc1[S@](=O)CC,2.0486
+247006,Please modify the molecule O=C(C[NH2+]Cc1ccco1)Nc1cccc(Br)c1 to increase its LogP value.,O=C(C[NH2+]Cc1ccco1)Nc1cccc(Br)c1,1.7442000000000002
+230083,Optimize the molecule C[C@H]1CCCN(C(=O)c2ccc(F)c(S(=O)(=O)N3CCCCC3)c2)C1 to have a lower LogP value.,C[C@H]1CCCN(C(=O)c2ccc(F)c(S(=O)(=O)N3CCCCC3)c2)C1,2.8724000000000016
+21227,Modify the molecule COc1ccc(/C=N/NC(=O)COc2ccccc2)cc1C to have a higher LogP value.,COc1ccc(/C=N/NC(=O)COc2ccccc2)cc1C,2.5327200000000003
+75701,Modify the molecule Cc1ccc([C@@](C)(O)CNC(=O)N[C@@H](C)CCCO)o1 to decrease its LogP value.,Cc1ccc([C@@](C)(O)CNC(=O)N[C@@H](C)CCCO)o1,1.2557199999999997
+64150,Modify the molecule c1ccc2c(C[NH+]3CC[C@H](Oc4cc[nH+]cc4)C3)coc2c1 to decrease its LogP value.,c1ccc2c(C[NH+]3CC[C@H](Oc4cc[nH+]cc4)C3)coc2c1,1.4830999999999992
+228897,Modify the molecule CC(C)N1C(=O)c2[nH]nc(-c3ccc(Cl)cc3)c2[C@H]1c1cccc([N+](=O)[O-])c1 to have a lower LogP value.,CC(C)N1C(=O)c2[nH]nc(-c3ccc(Cl)cc3)c2[C@H]1c1cccc([N+](=O)[O-])c1,4.591900000000003
+90034,Modify the molecule C[C@H]1CCN(C(=O)Nc2cccnc2Cl)C[C@H]1O to increase its LogP value.,C[C@H]1CCN(C(=O)Nc2cccnc2Cl)C[C@H]1O,1.9696000000000002
+48717,Optimize the molecule CCn1/c(=N/C(=O)c2cccnc2Cl)[nH]c2cc(Cl)ccc21 to have a higher LogP value.,CCn1/c(=N/C(=O)c2cccnc2Cl)[nH]c2cc(Cl)ccc21,3.4322000000000017
+12866,Please modify the molecule NC(=O)Nc1ccc(NC(=O)[C@H]2CCN(c3cc(F)cc(F)c3)C2=O)cc1 to increase its LogP value.,NC(=O)Nc1ccc(NC(=O)[C@H]2CCN(c3cc(F)cc(F)c3)C2=O)cc1,2.447000000000001
+42363,Modify the molecule CN(C)C(=O)c1ccc(CSc2nncn2C2CC2)cc1 to increase its LogP value.,CN(C)C(=O)c1ccc(CSc2nncn2C2CC2)cc1,2.607100000000001
+136327,Modify the molecule C[NH2+][C@H](C)c1cc(F)c(C)cc1SCCOC to increase its LogP value.,C[NH2+][C@H](C)c1cc(F)c(C)cc1SCCOC,2.1268200000000004
+170070,Modify the molecule CCCCC(=O)Nc1ccc(NC(=O)c2cc(C)nc(N)n2)cc1 to have a higher LogP value.,CCCCC(=O)Nc1ccc(NC(=O)c2cc(C)nc(N)n2)cc1,2.74822
+4948,Modify the molecule Cc1ccc(S(=O)(=O)NCCC(=O)Nc2ccc(F)cc2C)cc1C to decrease its LogP value.,Cc1ccc(S(=O)(=O)NCCC(=O)Nc2ccc(F)cc2C)cc1C,3.058060000000002
+24599,Optimize the molecule COC(=O)[C@H](C)N(C(=O)CCC1CCCC1)[C@@H]1CCS(=O)(=O)C1 to have a lower LogP value.,COC(=O)[C@H](C)N(C(=O)CCC1CCCC1)[C@@H]1CCS(=O)(=O)C1,1.534
+176977,Please optimize the molecule Cc1csc(Sc2cncc(C(=O)[O-])n2)n1 to have a higher LogP value.,Cc1csc(Sc2cncc(C(=O)[O-])n2)n1,0.75622
+67248,Modify the molecule N#C/C(=C/c1cccc(OC2CCCC2)c1)C(=O)[O-] to decrease its LogP value.,N#C/C(=C/c1cccc(OC2CCCC2)c1)C(=O)[O-],1.6648799999999992
+219235,Optimize the molecule COc1cc(C)c(C[NH2+]Cc2cccc(C)c2)cc1OC to have a higher LogP value.,COc1cc(C)c(C[NH2+]Cc2cccc(C)c2)cc1OC,2.5842400000000003
+205332,Optimize the molecule CN(C[C@@H](O)C1CC1)C(=O)CN(C)C(=O)c1ccc(Br)o1 to have a higher LogP value.,CN(C[C@@H](O)C1CC1)C(=O)CN(C)C(=O)c1ccc(Br)o1,1.3434000000000001
+224550,Please modify the molecule Cc1ncsc1CCS(=O)(=O)[C@H](C)c1ccc(C(F)(F)F)cc1 to increase its LogP value.,Cc1ncsc1CCS(=O)(=O)[C@H](C)c1ccc(C(F)(F)F)cc1,4.188820000000003
+197636,Please optimize the molecule C[C@H]1C[C@@H](C)C[NH+](Cc2c(O)ccc3c2O/C(=C/c2cccc([N+](=O)[O-])c2)C3=O)C1 to have a higher LogP value.,C[C@H]1C[C@@H](C)C[NH+](Cc2c(O)ccc3c2O/C(=C/c2cccc([N+](=O)[O-])c2)C3=O)C1,2.977400000000001
+243210,Optimize the molecule C=Cc1ccc(CN2C(=O)N(c3ccc(CC)cc3)[C@@H]3CS(=O)(=O)C[C@H]32)cc1 to have a lower LogP value.,C=Cc1ccc(CN2C(=O)N(c3ccc(CC)cc3)[C@@H]3CS(=O)(=O)C[C@H]32)cc1,3.4998000000000022
+243212,Please modify the molecule COC(=O)CCNC(=O)c1ccc(NC(=O)c2cc(F)c(F)cc2Cl)cc1 to increase its LogP value.,COC(=O)CCNC(=O)c1ccc(NC(=O)c2cc(F)c(F)cc2Cl)cc1,3.163400000000001
+6860,Modify the molecule C[C@@H](C(=O)N(C)CC(=O)NC1CC1)[NH+](C)Cc1ccc(F)c(F)c1 to have a higher LogP value.,C[C@@H](C(=O)N(C)CC(=O)NC1CC1)[NH+](C)Cc1ccc(F)c(F)c1,0.10500000000000176
+105222,Optimize the molecule CC(=O)c1c[nH]c(C(=O)Nc2cccc(COC[C@@H]3CCCCO3)c2)c1 to have a lower LogP value.,CC(=O)c1c[nH]c(C(=O)Nc2cccc(COC[C@@H]3CCCCO3)c2)c1,3.5553000000000026
+114873,Optimize the molecule CCCc1cc(C(=O)Nc2ccc(Br)cn2)cs1 to have a lower LogP value.,CCCc1cc(C(=O)Nc2ccc(Br)cn2)cs1,4.110400000000002
+181042,Modify the molecule CCOC[C@H](C)N1CCC[NH+]2CCC[C@@H]2C1 to increase its LogP value.,CCOC[C@H](C)N1CCC[NH+]2CCC[C@@H]2C1,0.16440000000000232
+62704,Please modify the molecule O=C(COc1ccc2ccc(=O)oc2c1)N[C@@H]1COc2ccccc2C1 to increase its LogP value.,O=C(COc1ccc2ccc(=O)oc2c1)N[C@@H]1COc2ccccc2C1,2.2916999999999996
+5978,Please optimize the molecule Cc1cnc(C(=O)N2CCN(Cc3cccc(-c4noc(-c5cccnc5)n4)c3)CC2)cn1 to have a lower LogP value.,Cc1cnc(C(=O)N2CCN(Cc3cccc(-c4noc(-c5cccnc5)n4)c3)CC2)cn1,2.8550200000000014
+69495,Modify the molecule COc1cc(Cl)c(C)cc1NC(=O)CNc1ccccc1-n1cccn1 to decrease its LogP value.,COc1cc(Cl)c(C)cc1NC(=O)CNc1ccccc1-n1cccn1,3.893320000000002
+82732,Please modify the molecule Cc1c(Cl)cccc1Nc1ncnc(NC[C@@H]2CCCO2)c1N to increase its LogP value.,Cc1c(Cl)cccc1Nc1ncnc(NC[C@@H]2CCCO2)c1N,3.3551200000000003
+76098,Optimize the molecule O=C(CS[C@H](c1ccccc1)c1ccc(Cl)cc1)Nc1cccnc1 to have a lower LogP value.,O=C(CS[C@H](c1ccccc1)c1ccc(Cl)cc1)Nc1cccnc1,5.1963000000000035
+77952,Modify the molecule Cc1cc(=O)oc2cc(OCCN3C[C@@H](C)OC[C@@H]3C)ccc12 to have a lower LogP value.,Cc1cc(=O)oc2cc(OCCN3C[C@@H](C)OC[C@@H]3C)ccc12,2.5894200000000005
+140629,Optimize the molecule Cc1ccc([C@@]2(C)NC(=O)N(C[C@H](O)c3cc(C)ccc3C)C2=O)cc1 to have a lower LogP value.,Cc1ccc([C@@]2(C)NC(=O)N(C[C@H](O)c3cc(C)ccc3C)C2=O)cc1,3.1124600000000013
+36164,Optimize the molecule C[C@H]1C[C@@H](C)CN(C(=O)c2nn(C)c3c2CS(=O)(=O)c2ccccc2-3)C1 to have a lower LogP value.,C[C@H]1C[C@@H](C)CN(C(=O)c2nn(C)c3c2CS(=O)(=O)c2ccccc2-3)C1,2.4925000000000006
+46430,Please optimize the molecule Cc1ccccc1CCNC(=O)c1cccc2[nH]ccc12 to have a higher LogP value.,Cc1ccccc1CCNC(=O)c1cccc2[nH]ccc12,3.4488200000000013
+102503,Please modify the molecule O=C(CC[NH+](CC1CC1)C1CCCCC1)N1CCCCC1 to decrease its LogP value.,O=C(CC[NH+](CC1CC1)C1CCCCC1)N1CCCCC1,2.0165999999999995
+223430,Please optimize the molecule Cc1cc(Br)ccc1NC(=O)COc1ccc([N+](=O)[O-])cc1C to have a higher LogP value.,Cc1cc(Br)ccc1NC(=O)COc1ccc([N+](=O)[O-])cc1C,3.991640000000002
+6053,Please modify the molecule C[C@@H]1CN(Cc2ccc(C3CC3)cc2)[C@H](C)C[NH2+]1 to increase its LogP value.,C[C@@H]1CN(Cc2ccc(C3CC3)cc2)[C@H](C)C[NH2+]1,1.72
+118863,Modify the molecule Cc1ccc([C@H]2C[C@@H](c3cccc4ccccc34)n3ncnc3N2)cc1 to have a lower LogP value.,Cc1ccc([C@H]2C[C@@H](c3cccc4ccccc34)n3ncnc3N2)cc1,4.886020000000004
+80999,Modify the molecule C[C@H](CS(C)(=O)=O)NC(=O)NCc1ccccc1OC(C)(C)C to decrease its LogP value.,C[C@H](CS(C)(=O)=O)NC(=O)NCc1ccccc1OC(C)(C)C,2.096199999999999
+53670,Modify the molecule Cc1n[nH]c(C)c1CNC(=O)c1ccnc(OC(C)(C)C)c1 to have a lower LogP value.,Cc1n[nH]c(C)c1CNC(=O)c1ccnc(OC(C)(C)C)c1,2.5288400000000006
+92368,Please modify the molecule CCCC(=O)NCc1ccc(Cn2ccnc2)cc1 to decrease its LogP value.,CCCC(=O)NCc1ccc(Cn2ccnc2)cc1,2.3477000000000006
+32414,Please modify the molecule Cc1ccsc1CNC(=O)C[NH+]1CC(C)(C)C1(C)C to increase its LogP value.,Cc1ccsc1CNC(=O)C[NH+]1CC(C)(C)C1(C)C,1.3760199999999994
+96760,Modify the molecule Cc1ccc(C(=O)Oc2cc(F)ccc2[N+](=O)[O-])c(C)n1 to have a lower LogP value.,Cc1ccc(C(=O)Oc2cc(F)ccc2[N+](=O)[O-])c(C)n1,2.9649400000000012
+64018,Optimize the molecule CCCO[C@H]1CCCN(C(=O)COCc2ccccc2)CC1 to have a lower LogP value.,CCCO[C@H]1CCCN(C(=O)COCc2ccccc2)CC1,3.010900000000002
+234758,Modify the molecule Cc1ccc(NC(=O)CSc2nnc(-c3cccnc3)n2C)c(C)c1 to have a lower LogP value.,Cc1ccc(NC(=O)CSc2nnc(-c3cccnc3)n2C)c(C)c1,3.2247400000000015
+16593,Modify the molecule CN(CCC(N)=S)C(=O)COc1cccc2ccccc12 to have a higher LogP value.,CN(CCC(N)=S)C(=O)COc1cccc2ccccc12,2.3532
+223312,Please modify the molecule COc1ccc(CNC(=O)Cc2c(C)c3c(cc(C)c4c(C)c(C)oc43)oc2=O)cc1OC to increase its LogP value.,COc1ccc(CNC(=O)Cc2c(C)c3c(cc(C)c4c(C)c(C)oc43)oc2=O)cc1OC,4.648980000000003
+205142,Modify the molecule Cc1cc(Cl)cc2sc(N)nc12 to decrease its LogP value.,Cc1cc(Cl)cc2sc(N)nc12,2.84032
+49351,Please modify the molecule N#C[C@@H]1[C@@H]2C(=O)N(c3ccc(F)cc3)C(=O)[C@@H]2[C@@H]2c3ccccc3C=CN12 to increase its LogP value.,N#C[C@@H]1[C@@H]2C(=O)N(c3ccc(F)cc3)C(=O)[C@@H]2[C@@H]2c3ccccc3C=CN12,2.8646800000000017
+75735,Optimize the molecule CC(C)Cc1nnc(NC(=O)[C@H]2NN(c3cccc(Cl)c3)C=CC2=O)s1 to have a lower LogP value.,CC(C)Cc1nnc(NC(=O)[C@H]2NN(c3cccc(Cl)c3)C=CC2=O)s1,2.8047000000000013
+107297,Modify the molecule CCCc1noc(CN2CCc3cc(F)ccc3C2)n1 to have a higher LogP value.,CCCc1noc(CN2CCc3cc(F)ccc3C2)n1,2.719500000000001
+49405,Modify the molecule CN(C[C@@H]1CCC[NH+]1C)S(=O)(=O)c1cc(CO)oc1Br to have a higher LogP value.,CN(C[C@@H]1CCC[NH+]1C)S(=O)(=O)c1cc(CO)oc1Br,-0.16799999999999965
+99546,Optimize the molecule CC(C)C[NH+](C)CN1C(=O)N[C@]2(CCCN(Cc3ccccc3)C2)C1=O to have a lower LogP value.,CC(C)C[NH+](C)CN1C(=O)N[C@]2(CCCN(Cc3ccccc3)C2)C1=O,0.7012000000000018
+92711,Optimize the molecule CSCCCCNC(=O)N(C)[C@@H](C)c1ccccn1 to have a lower LogP value.,CSCCCCNC(=O)N(C)[C@@H](C)c1ccccn1,2.927200000000001
+241030,Modify the molecule CCOC(=O)C1=C(C)OC(N)=C(C#N)[C@H]1c1cc(Cn2cnc3ccccc32)cs1 to have a higher LogP value.,CCOC(=O)C1=C(C)OC(N)=C(C#N)[C@H]1c1cc(Cn2cnc3ccccc32)cs1,3.7908800000000022
+43165,Modify the molecule CC[C@H](NC(=O)C[C@H](O)c1ccc(Cl)cc1)c1nccs1 to have a higher LogP value.,CC[C@H](NC(=O)C[C@H](O)c1ccc(Cl)cc1)c1nccs1,3.4875000000000025
+23707,Please optimize the molecule CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C1CCS(=O)(=O)CC1 to have a higher LogP value.,CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C1CCS(=O)(=O)CC1,3.7332000000000027
+34256,Modify the molecule CCCc1nnc(NC(=O)c2cccc(S(=O)(=O)N3CCCC3)c2)s1 to have a higher LogP value.,CCCc1nnc(NC(=O)c2cccc(S(=O)(=O)N3CCCC3)c2)s1,2.527400000000001
+167994,Please optimize the molecule COc1cc(OC)cc(C(=O)Nc2ccc(-c3nc4cnccc4o3)c(O)c2)c1 to have a lower LogP value.,COc1cc(OC)cc(C(=O)Nc2ccc(-c3nc4cnccc4o3)c(O)c2)c1,3.8649000000000022
+82349,Please optimize the molecule O=C([O-])c1cc(F)c(F)c(O)c1F to have a lower LogP value.,O=C([O-])c1cc(F)c(F)c(O)c1F,0.173
+40664,Modify the molecule O=c1c([N+](=O)[O-])c(NC[C@@H](O)C[NH+]2CCc3ccccc3C2)nc2ccccn12 to decrease its LogP value.,O=c1c([N+](=O)[O-])c(NC[C@@H](O)C[NH+]2CCc3ccccc3C2)nc2ccccn12,0.01670000000000038
+47142,Please optimize the molecule Brc1cc(CN[C@@H](c2ccccc2)c2ccccn2)cc2c1OCO2 to have a lower LogP value.,Brc1cc(CN[C@@H](c2ccccc2)c2ccccn2)cc2c1OCO2,4.452000000000003
+17580,Modify the molecule C[C@H]1CC(NC(=O)Cc2ccccc2O)C[C@H](C)O1 to have a higher LogP value.,C[C@H]1CC(NC(=O)Cc2ccccc2O)C[C@H](C)O1,2.0069
+14662,Modify the molecule CS(=O)(=O)c1cc(Cl)cnc1[C@H]1CCCN(C(=O)c2ccncc2)C1 to have a lower LogP value.,CS(=O)(=O)c1cc(Cl)cnc1[C@H]1CCCN(C(=O)c2ccncc2)C1,2.553300000000001
+2502,Please modify the molecule Cc1nccn1-c1cc(N2CCC(C(=O)Nc3ccc(F)c(F)c3)CC2)ncn1 to decrease its LogP value.,Cc1nccn1-c1cc(N2CCC(C(=O)Nc3ccc(F)c(F)c3)CC2)ncn1,3.104020000000001
+135507,Modify the molecule C[C@@H]1CCCC[C@@H]1[NH2+]CCN1C(=O)CCC1=O to have a higher LogP value.,C[C@@H]1CCCC[C@@H]1[NH2+]CCN1C(=O)CCC1=O,0.27749999999999986
+126597,Modify the molecule CC(C)CCNC(=O)C(=O)Nc1cc(Br)c(=O)n(C)c1 to increase its LogP value.,CC(C)CCNC(=O)C(=O)Nc1cc(Br)c(=O)n(C)c1,1.2485999999999993
+7106,Modify the molecule CCOC(=O)Cc1csc(Nc2cccc(Cl)c2)n1 to have a higher LogP value.,CCOC(=O)Cc1csc(Nc2cccc(Cl)c2)n1,3.6457000000000024
+31209,Please optimize the molecule CC[C@@H]1c2ccsc2CCN1C(=O)CCc1c(C)nc(C)[nH]c1=O to have a lower LogP value.,CC[C@@H]1c2ccsc2CCN1C(=O)CCc1c(C)nc(C)[nH]c1=O,2.9168400000000005
+23005,Optimize the molecule Cc1cnc(CCNC(=O)N(C)[C@@H](C)[C@H](C)c2ccc(Cl)cc2)s1 to have a higher LogP value.,Cc1cnc(CCNC(=O)N(C)[C@@H](C)[C@H](C)c2ccc(Cl)cc2)s1,4.4810200000000036
+7215,Please modify the molecule C[C@@H]1CCC[C@@H](NC(=O)C(=O)Nc2cccc(Br)c2)[C@@H]1C to increase its LogP value.,C[C@@H]1CCC[C@@H](NC(=O)C(=O)Nc2cccc(Br)c2)[C@@H]1C,3.328500000000002
+212303,Modify the molecule C=CCCCC(=O)[C@H]1CSCCS1 to have a lower LogP value.,C=CCCCC(=O)[C@H]1CSCCS1,2.7604000000000015
+1806,Modify the molecule O=C(NCCc1cccc(O)c1)N1CCC[C@H]1CN1CCOCC1 to have a lower LogP value.,O=C(NCCc1cccc(O)c1)N1CCC[C@H]1CN1CCOCC1,1.4409
+119461,Optimize the molecule COc1ccc(OC)c(CN(C)S(=O)(=O)c2cc(C)c(C)s2)c1 to have a higher LogP value.,COc1ccc(OC)c(CN(C)S(=O)(=O)c2cc(C)c(C)s2)c1,3.202840000000002
+66973,Please modify the molecule Oc1ccc(-c2nc3ccccc3s2)cc1Cl to decrease its LogP value.,Oc1ccc(-c2nc3ccccc3s2)cc1Cl,4.322300000000001
+61142,Modify the molecule CC(C)c1ccc(NC(=O)/C(N)=N\O)cc1 to increase its LogP value.,CC(C)c1ccc(NC(=O)/C(N)=N\O)cc1,1.4949
+125139,Modify the molecule C[C@H]1CCC[C@H](C)N1C(=O)Cn1ccc(-c2ccccc2)n1 to have a lower LogP value.,C[C@H]1CCC[C@H](C)N1C(=O)Cn1ccc(-c2ccccc2)n1,3.3396000000000017
+224894,Optimize the molecule Cc1cnccc1-n1nc(C(C)C)nc1-c1cnc2cccc(C)n2c1=O to have a higher LogP value.,Cc1cnccc1-n1nc(C(C)C)nc1-c1cnc2cccc(C)n2c1=O,3.077440000000001
+194362,Modify the molecule NC(=O)c1ccc(NC(=O)Cn2ccc3cc(Cl)ccc32)cc1 to decrease its LogP value.,NC(=O)c1ccc(NC(=O)Cn2ccc3cc(Cl)ccc32)cc1,3.032300000000001
+134315,Please optimize the molecule COc1ccc(Cc2nc(N)nc(C)c2C(=O)NN)cc1 to have a lower LogP value.,COc1ccc(Cc2nc(N)nc(C)c2C(=O)NN)cc1,0.5701200000000002
+198111,Optimize the molecule C[C@@H](C(=O)NC(=O)NC(C)(C)C)N1CCN(c2ncccc2C#N)CC1 to have a lower LogP value.,C[C@@H](C(=O)NC(=O)NC(C)(C)C)N1CCN(c2ncccc2C#N)CC1,1.0880800000000002
+36277,Optimize the molecule Cc1ccc([C@@H](C)NC(=O)Nc2ccccc2CC(N)=O)cc1F to have a higher LogP value.,Cc1ccc([C@@H](C)NC(=O)Nc2ccccc2CC(N)=O)cc1F,3.044620000000001
+13663,Modify the molecule CCOc1ccc(C=O)c(C)n1 to increase its LogP value.,CCOc1ccc(C=O)c(C)n1,1.6012199999999999
+216626,Optimize the molecule Nc1cnc(-c2ccnc(N)n2)cn1 to have a higher LogP value.,Nc1cnc(-c2ccnc(N)n2)cn1,0.09799999999999998
+175864,Optimize the molecule COC[C@@H](O)C[NH+]1CCC(N[C@H](C)c2cccc3ccccc23)CC1 to have a higher LogP value.,COC[C@@H](O)C[NH+]1CCC(N[C@H](C)c2cccc3ccccc23)CC1,1.5450000000000013
+41207,Please modify the molecule CC(C)C(=O)N[C@H]1CCC[NH+]([C@@H]2CC[C@H](C)C2)C1 to decrease its LogP value.,CC(C)C(=O)N[C@H]1CCC[NH+]([C@@H]2CC[C@H](C)C2)C1,0.994500000000001
+88040,Please optimize the molecule CCOc1ccccc1NC(=O)c1cccc(OC)c1 to have a higher LogP value.,CCOc1ccccc1NC(=O)c1cccc(OC)c1,3.3462000000000014
+126992,Modify the molecule CNS(=O)(=O)c1ccc(CNC(=O)c2c(C)nn(C)c2C)cc1 to have a higher LogP value.,CNS(=O)(=O)c1ccc(CNC(=O)c2c(C)nn(C)c2C)cc1,0.8750399999999994
+222320,Optimize the molecule CN(c1ccc2nnc(-c3ccccc3F)n2n1)[C@@H]1CCC[NH+](C)C1 to have a lower LogP value.,CN(c1ccc2nnc(-c3ccccc3F)n2n1)[C@@H]1CCC[NH+](C)C1,1.0436999999999996
+226975,Please optimize the molecule COCCn1ccc2ccc(NC(=O)N3CCC[C@@H](C)[C@H]3CO)cc21 to have a higher LogP value.,COCCn1ccc2ccc(NC(=O)N3CCC[C@@H](C)[C@H]3CO)cc21,2.9124000000000017
+214969,Please optimize the molecule COc1cc(CN2CCN(Cc3cnc(C4CC4)s3)CC2)cc(OC)c1 to have a higher LogP value.,COc1cc(CN2CCN(Cc3cnc(C4CC4)s3)CC2)cc(OC)c1,3.355500000000002
+108843,Please optimize the molecule O=C(c1csc(-c2ccsc2)n1)N1CCO[C@@H]2CCCC[C@@H]21 to have a higher LogP value.,O=C(c1csc(-c2ccsc2)n1)N1CCO[C@@H]2CCCC[C@@H]21,3.6552000000000016
+196317,Modify the molecule Cc1c(Br)c(C(F)(F)F)nn1[C@@H](C)C(=O)Nc1cnn(CC2CC2)c1 to increase its LogP value.,Cc1c(Br)c(C(F)(F)F)nn1[C@@H](C)C(=O)Nc1cnn(CC2CC2)c1,3.779020000000002
+30454,Optimize the molecule CCOC(=O)c1sc(Sc2ccc(C(F)(F)F)cc2[N+](=O)[O-])nc1C to have a lower LogP value.,CCOC(=O)c1sc(Sc2ccc(C(F)(F)F)cc2[N+](=O)[O-])nc1C,4.706420000000002
+222995,Please optimize the molecule COCC[C@]1(C(=O)[O-])CCCN(C(=O)c2ccc(=O)[nH]c2)C1 to have a higher LogP value.,COCC[C@]1(C(=O)[O-])CCCN(C(=O)c2ccc(=O)[nH]c2)C1,-0.6162999999999985
+118066,Please modify the molecule COCc1nnc(NC(=O)c2ccc(N3CNc4ccccc4C3=O)cc2)s1 to increase its LogP value.,COCc1nnc(NC(=O)c2ccc(N3CNc4ccccc4C3=O)cc2)s1,2.9666000000000015
+200558,Please modify the molecule Cc1c(C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)sc2nc(Cc3ccccc3)[nH]c(=O)c12 to increase its LogP value.,Cc1c(C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)sc2nc(Cc3ccccc3)[nH]c(=O)c12,4.374720000000003
+54214,Modify the molecule CN(C)C(=O)c1cccc(NC(=O)C[NH+]2CCCC[C@@H]2C(N)=O)c1 to decrease its LogP value.,CN(C)C(=O)c1cccc(NC(=O)C[NH+]2CCCC[C@@H]2C(N)=O)c1,-0.7503999999999971
+233638,Please optimize the molecule C[C@@H](c1nc([C@H]2C[NH+](C)CCN2C)no1)[C@H](O)C(F)(F)F to have a higher LogP value.,C[C@@H](c1nc([C@H]2C[NH+](C)CCN2C)no1)[C@H](O)C(F)(F)F,-0.4024999999999998
+205111,Please modify the molecule Nc1ccc(SCc2ccc(Cl)cc2)nc1 to decrease its LogP value.,Nc1ccc(SCc2ccc(Cl)cc2)nc1,3.6095000000000015
+105010,Optimize the molecule CC1CCN(S(=O)(=O)c2cccn(CC#N)c2=O)CC1 to have a higher LogP value.,CC1CCN(S(=O)(=O)c2cccn(CC#N)c2=O)CC1,0.7924800000000001
+51745,Modify the molecule FC(F)(F)c1ccc(O[C@H]2CCN(CCn3cc[nH+]c3)C2)nc1 to decrease its LogP value.,FC(F)(F)c1ccc(O[C@H]2CCN(CCn3cc[nH+]c3)C2)nc1,1.8692999999999997
+177298,Modify the molecule CSc1ccccc1[C@@H](O)[C@H](C[NH3+])c1c(F)cccc1Cl to have a lower LogP value.,CSc1ccccc1[C@@H](O)[C@H](C[NH3+])c1c(F)cccc1Cl,3.2601000000000013
+166411,Optimize the molecule Cc1cc(C(=O)Nc2ccc(-n3ccnc3)c(F)c2)c2c(=O)[nH]n(C)c2n1 to have a higher LogP value.,Cc1cc(C(=O)Nc2ccc(-n3ccnc3)c(F)c2)c2c(=O)[nH]n(C)c2n1,2.14712
+64401,Please modify the molecule S=C(Nc1cccc(Cl)c1Cl)N(Cc1ccc2c(c1)OCO2)Cc1ccccn1 to decrease its LogP value.,S=C(Nc1cccc(Cl)c1Cl)N(Cc1ccc2c(c1)OCO2)Cc1ccccn1,5.516300000000004
+95880,Optimize the molecule C[C@@H](NC(=O)NNC(=O)C(C)(C)C)c1noc(-c2ccc(Cl)cc2)n1 to have a lower LogP value.,C[C@@H](NC(=O)NNC(=O)C(C)(C)C)c1noc(-c2ccc(Cl)cc2)n1,2.8275000000000006
+177699,Modify the molecule C[C@@H]1CCN(c2ccc([N+](=O)[O-])c(S(C)(=O)=O)c2)C[C@@H]1O to decrease its LogP value.,C[C@@H]1CCN(c2ccc([N+](=O)[O-])c(S(C)(=O)=O)c2)C[C@@H]1O,1.2054
+224490,Please optimize the molecule C[C@@H](C(=O)NCc1ccc(Cl)cc1)N(C)CC#N to have a lower LogP value.,C[C@@H](C(=O)NCc1ccc(Cl)cc1)N(C)CC#N,1.80008
+55076,Modify the molecule NC(=O)c1cc(Cl)ccc1NCC(=O)N1CCC[C@H]2CCCC[C@H]21 to have a lower LogP value.,NC(=O)c1cc(Cl)ccc1NCC(=O)N1CCC[C@H]2CCCC[C@H]21,3.032000000000002
+145635,Modify the molecule C[C@H](CCc1cccn1C)NC(=O)C(=O)Nc1ccnn1C(C)(C)C to increase its LogP value.,C[C@H](CCc1cccn1C)NC(=O)C(=O)Nc1ccnn1C(C)(C)C,2.0525999999999995
+30563,Modify the molecule CCOC(=O)c1cnn([C@@H]2CCCN(C(=O)c3cc(C)ccc3O)C2)c1 to have a higher LogP value.,CCOC(=O)c1cnn([C@@H]2CCCN(C(=O)c3cc(C)ccc3O)C2)c1,2.551120000000001
+183415,Modify the molecule CCCN(C(=O)[C@@H](C)N[C@@H](C)c1ccc(C)cc1)[C@H]1CCS(=O)(=O)C1 to increase its LogP value.,CCCN(C(=O)[C@@H](C)N[C@@H](C)c1ccc(C)cc1)[C@H]1CCS(=O)(=O)C1,2.4598199999999997
+42202,Please modify the molecule CNC(=O)CN(C)C(=O)CCCNC(=O)c1ccco1 to decrease its LogP value.,CNC(=O)CN(C)C(=O)CCCNC(=O)c1ccco1,-0.005999999999999728
+113054,Optimize the molecule CCc1nsc(SCC(=O)c2ccc(F)cc2)n1 to have a lower LogP value.,CCc1nsc(SCC(=O)c2ccc(F)cc2)n1,3.2146000000000017
+169704,Please optimize the molecule COC(=O)C[C@H](NC(=O)Nc1cccnc1OC)c1cccs1 to have a higher LogP value.,COC(=O)C[C@H](NC(=O)Nc1cccnc1OC)c1cccs1,2.5776000000000003
+56376,Modify the molecule C[C@@H]1C[C@@H]1C(=O)Nc1ccc2c(c1)N(C)C(=O)CO2 to have a higher LogP value.,C[C@@H]1C[C@@H]1C(=O)Nc1ccc2c(c1)N(C)C(=O)CO2,1.6362999999999999
+1331,Please optimize the molecule O=Cc1ccc(-c2cc(C(F)(F)F)cc(Cl)n2)cc1 to have a higher LogP value.,O=Cc1ccc(-c2cc(C(F)(F)F)cc(Cl)n2)cc1,4.233300000000002
+113821,Please modify the molecule C[C@@H](Cc1ccc(O)cc1)NC(=O)C(=O)Nc1ccc(Oc2ccccc2)cc1 to decrease its LogP value.,C[C@@H](Cc1ccc(O)cc1)NC(=O)C(=O)Nc1ccc(Oc2ccccc2)cc1,3.870400000000002
+157998,Optimize the molecule CCc1ccc(CN[C@@](C)(CC(C)C)C(N)=O)cc1 to have a lower LogP value.,CCc1ccc(CN[C@@](C)(CC(C)C)C(N)=O)cc1,2.6287000000000003
+132855,Optimize the molecule CC(=O)Nc1ccc(C)cc1S(=O)(=O)Nc1ccc(C2(C(=O)NC(C)C)CC2)cc1 to have a higher LogP value.,CC(=O)Nc1ccc(C)cc1S(=O)(=O)Nc1ccc(C2(C(=O)NC(C)C)CC2)cc1,3.3104200000000024
+197123,Please modify the molecule O=C(/C=C/C1CC1)NCCOc1cccc2ccccc12 to increase its LogP value.,O=C(/C=C/C1CC1)NCCOc1cccc2ccccc12,3.301000000000002
+154231,Optimize the molecule CC(C)NC(=O)C(=O)N/N=C/c1ccccn1 to have a higher LogP value.,CC(C)NC(=O)C(=O)N/N=C/c1ccccn1,0.05629999999999935
+52989,Optimize the molecule COCCCC(=O)N1CCCC[C@H]1[C@H]1CCC[NH2+]1 to have a higher LogP value.,COCCCC(=O)N1CCCC[C@H]1[C@H]1CCC[NH2+]1,0.5199000000000013
+106343,Modify the molecule CCC(CC)[NH+](C)CCS(=O)(=O)c1cccc(Br)c1 to have a lower LogP value.,CCC(CC)[NH+](C)CCS(=O)(=O)c1cccc(Br)c1,1.9261000000000004
+36073,Optimize the molecule CC(C)C[NH+]1[C@H]2CCC[C@@H]1CC(NC(=S)Nc1cccc(Cl)c1)C2 to have a higher LogP value.,CC(C)C[NH+]1[C@H]2CCC[C@@H]1CC(NC(=S)Nc1cccc(Cl)c1)C2,3.250800000000001
+126040,Please optimize the molecule C[C@H](O)CC(C)(C)C[NH2+][C@@H](C)CC(F)(F)F to have a lower LogP value.,C[C@H](O)CC(C)(C)C[NH2+][C@@H](C)CC(F)(F)F,1.6878
+191576,Modify the molecule Cc1cccc(NCC(=O)Nc2ccc(OC[C@@H]3CCCO3)cc2)c1 to decrease its LogP value.,Cc1cccc(NCC(=O)Nc2ccc(OC[C@@H]3CCCO3)cc2)c1,3.6034200000000025
+130338,Modify the molecule CSC1(CNc2ccc([N+](=O)[O-])cc2Cl)CCOCC1 to increase its LogP value.,CSC1(CNc2ccc([N+](=O)[O-])cc2Cl)CCOCC1,3.572300000000002
+239747,Please modify the molecule Cc1cn(-c2ccccc2Cl)nc1NC(=O)C(=O)N[C@@H](CO)c1ccccc1 to increase its LogP value.,Cc1cn(-c2ccccc2Cl)nc1NC(=O)C(=O)N[C@@H](CO)c1ccccc1,2.622420000000001
+71296,Optimize the molecule C[C@H](Cc1cccs1)C(=O)Nc1cccc(C[NH+]2CCC(O)CC2)c1 to have a higher LogP value.,C[C@H](Cc1cccs1)C(=O)Nc1cccc(C[NH+]2CCC(O)CC2)c1,2.1049999999999995
+39142,Please modify the molecule O=C(CSCc1ccccc1)N/N=C/c1cc(Br)cc(Br)c1O to decrease its LogP value.,O=C(CSCc1ccccc1)N/N=C/c1cc(Br)cc(Br)c1O,4.300700000000003
+187157,Please modify the molecule C[NH2+][C@@H]1[C@H]([NH+](C)Cc2ccc(F)cc2)CCCC1(C)C to decrease its LogP value.,C[NH2+][C@@H]1[C@H]([NH+](C)Cc2ccc(F)cc2)CCCC1(C)C,0.9809000000000012
+56090,Modify the molecule C=CCN1C(=O)NC(=N)C1(CCC)CCC to have a higher LogP value.,C=CCN1C(=O)NC(=N)C1(CCC)CCC,2.5138700000000007
+35264,Please optimize the molecule Nc1cc(N2CCC[C@@H](c3n[nH]c(=O)n3-c3ccccc3)C2)ncn1 to have a higher LogP value.,Nc1cc(N2CCC[C@@H](c3n[nH]c(=O)n3-c3ccccc3)C2)ncn1,1.3168
+65027,Please optimize the molecule CCCC[NH+]1CCC(NC(=O)NC[C@H]2C[C@]23CCc2ccccc23)CC1 to have a lower LogP value.,CCCC[NH+]1CCC(NC(=O)NC[C@H]2C[C@]23CCc2ccccc23)CC1,2.0371000000000015
+25364,Please optimize the molecule Cc1cc2occ(CC(=O)OCC3(C)COC3)c2cc1C to have a lower LogP value.,Cc1cc2occ(CC(=O)OCC3(C)COC3)c2cc1C,3.1718400000000013
+165760,Modify the molecule C[C@@H](Oc1ccccc1C#N)C(=O)Nc1ccn(Cc2ccccn2)n1 to have a lower LogP value.,C[C@@H](Oc1ccccc1C#N)C(=O)Nc1ccn(Cc2ccccn2)n1,2.6040800000000006
+185120,Optimize the molecule CC[NH2+]C1CCN(c2ccc(OC)cc2OC)CC1 to have a higher LogP value.,CC[NH2+]C1CCN(c2ccc(OC)cc2OC)CC1,1.2559000000000007
+2183,Modify the molecule COc1ccc(OC)c2sc(NC(=O)c3cc4c(ccc5ccccc54)oc3=O)nc12 to have a higher LogP value.,COc1ccc(OC)c2sc(NC(=O)c3cc4c(ccc5ccccc54)oc3=O)nc12,4.825400000000003
+194370,Optimize the molecule N#Cc1ccc(S(=O)(=O)CCN2CCC[C@H]2c2cccs2)cc1 to have a higher LogP value.,N#Cc1ccc(S(=O)(=O)CCN2CCC[C@H]2c2cccs2)cc1,3.2305800000000024
+221410,Modify the molecule COC(=O)c1cncc(N2C[C@@H](C)OC[C@H]2C)n1 to have a lower LogP value.,COC(=O)c1cncc(N2C[C@@H](C)OC[C@H]2C)n1,0.8768
+187082,Please modify the molecule Cc1ccc([C@@H]2SC[C@@H]3C(=O)N(c4cnn(C)c4C)C(=S)N32)cc1 to increase its LogP value.,Cc1ccc([C@@H]2SC[C@@H]3C(=O)N(c4cnn(C)c4C)C(=S)N32)cc1,2.7846400000000013
+243358,Please optimize the molecule Cc1ccc(NC(=O)COc2ccc(Br)cn2)cc1 to have a lower LogP value.,Cc1ccc(NC(=O)COc2ccc(Br)cn2)cc1,3.170020000000001
+86398,Modify the molecule CC[C@H](Sc1c([O-])on[n+]1-c1ccc(OC)cc1)C(=O)Nc1ccc(C)c(C)c1 to decrease its LogP value.,CC[C@H](Sc1c([O-])on[n+]1-c1ccc(OC)cc1)C(=O)Nc1ccc(C)c(C)c1,3.159740000000002
+20953,Modify the molecule Cc1[nH]ncc1S(=O)(=O)N[C@@H]1CC[NH2+]C[C@@H]1C to increase its LogP value.,Cc1[nH]ncc1S(=O)(=O)N[C@@H]1CC[NH2+]C[C@@H]1C,-1.0317799999999981
+47362,Optimize the molecule CC(=O)c1csc(N(C)Cc2cccc(C)n2)n1 to have a lower LogP value.,CC(=O)c1csc(N(C)Cc2cccc(C)n2)n1,2.6855200000000004
+82654,Modify the molecule C[C@@H]1CC(N(C)[C@@H](c2ccccc2)C(F)(F)F)C[C@@H](C)O1 to have a lower LogP value.,C[C@@H]1CC(N(C)[C@@H](c2ccccc2)C(F)(F)F)C[C@@H](C)O1,4.177800000000004
+157664,Please optimize the molecule COc1ccc(CNC(=O)Cn2c(N3CCCCC3)nc3ccsc3c2=O)cc1 to have a higher LogP value.,COc1ccc(CNC(=O)Cn2c(N3CCCCC3)nc3ccsc3c2=O)cc1,2.7733000000000008
+128614,Modify the molecule C[C@]1(C(=O)NC2CCCCCCC2)Oc2ccccc2NC1=O to increase its LogP value.,C[C@]1(C(=O)NC2CCCCCCC2)Oc2ccccc2NC1=O,3.005300000000001
+89246,Please optimize the molecule CC(C)Cn1cc(NC(=O)c2cccnc2[S-])cn1 to have a higher LogP value.,CC(C)Cn1cc(NC(=O)c2cccnc2[S-])cn1,2.0921999999999996
+244215,Please optimize the molecule CNC(=O)c1ccc([C@@H]2Nc3ccccc3C(=O)N2C[C@@H]2CCCO2)cc1 to have a lower LogP value.,CNC(=O)c1ccc([C@@H]2Nc3ccccc3C(=O)N2C[C@@H]2CCCO2)cc1,2.7917000000000014
+30639,Modify the molecule C[C@H](OC(=O)c1ccccc1Oc1cccnc1)[C@@H]1CCOC1 to increase its LogP value.,C[C@H](OC(=O)c1ccccc1Oc1cccnc1)[C@@H]1CCOC1,3.455700000000002
+13196,Please optimize the molecule CCN(C(=O)Cn1cc(S(=O)(=O)N2CCCCCC2)ccc1=O)c1ccccc1 to have a lower LogP value.,CCN(C(=O)Cn1cc(S(=O)(=O)N2CCCCCC2)ccc1=O)c1ccccc1,2.4661
+195964,Modify the molecule Cc1ccc(Cc2nnc(NC(=O)c3ccc4c(c3)OCO4)o2)c(C)c1 to have a higher LogP value.,Cc1ccc(Cc2nnc(NC(=O)c3ccc4c(c3)OCO4)o2)c(C)c1,3.2582400000000016
+58871,Please modify the molecule CCCN1CCc2nc[nH]c2C12CC[NH+](Cc1cc(OC)ccc1F)CC2 to increase its LogP value.,CCCN1CCc2nc[nH]c2C12CC[NH+](Cc1cc(OC)ccc1F)CC2,1.8997
+183437,Please modify the molecule C[C@H]1CSC(SCC(=O)Nc2ccccc2[N+](=O)[O-])=N1 to decrease its LogP value.,C[C@H]1CSC(SCC(=O)Nc2ccccc2[N+](=O)[O-])=N1,2.7578000000000005
+201670,Please optimize the molecule COCCn1c(C)c(C)c(S(=O)(=O)c2ccc(C)cc2)c1NC(=O)C1CCCCC1 to have a higher LogP value.,COCCn1c(C)c(C)c(S(=O)(=O)c2ccc(C)cc2)c1NC(=O)C1CCCCC1,4.411360000000004
+243106,Please modify the molecule CCC[C@@H](NC(=O)N1CCOCC1)C(N)=[NH2+] to increase its LogP value.,CCC[C@@H](NC(=O)N1CCOCC1)C(N)=[NH2+],-1.6867999999999963
+158620,Modify the molecule O[C@H]1CCC[C@H]1n1cccn1 to have a lower LogP value.,O[C@H]1CCC[C@H]1n1cccn1,0.969
+100864,Modify the molecule O=C(Nc1ccccc1)NC1CC[NH+](C[C@H](O)c2ccc(F)c(F)c2)CC1 to decrease its LogP value.,O=C(Nc1ccccc1)NC1CC[NH+](C[C@H](O)c2ccc(F)c(F)c2)CC1,1.8672000000000002
+22567,Modify the molecule N#Cc1ccc(COC(=O)c2nn(-c3ccccc3F)cc2Br)cc1 to increase its LogP value.,N#Cc1ccc(COC(=O)c2nn(-c3ccccc3F)cc2Br)cc1,4.002580000000002
+56045,Please modify the molecule Cc1cc(N)cc(C)c1S(=O)(=O)NCC1CC1 to increase its LogP value.,Cc1cc(N)cc(C)c1S(=O)(=O)NCC1CC1,1.57394
+56303,Optimize the molecule COc1ccccc1-n1nc(C(=O)N2CCCC[C@H]2C)c2ccccc2c1=O to have a higher LogP value.,COc1ccccc1-n1nc(C(=O)N2CCCC[C@H]2C)c2ccccc2c1=O,3.408900000000002
+220102,Please modify the molecule CNC(=O)c1cccc(NC(=O)[C@H](C)[NH+]2CCC([C@H](O)c3ccccc3)CC2)c1 to increase its LogP value.,CNC(=O)c1cccc(NC(=O)[C@H](C)[NH+]2CCC([C@H](O)c3ccccc3)CC2)c1,1.401700000000001
+4731,Modify the molecule COc1ccc(C)cc1[C@@H](C)[NH2+][C@H](C)C(=O)Nc1ccc(C)cc1F to have a lower LogP value.,COc1ccc(C)cc1[C@@H](C)[NH2+][C@H](C)C(=O)Nc1ccc(C)cc1F,3.1027400000000007
+146418,Modify the molecule C[C@@H]1CCC[C@H](CC(=O)Nc2ccc(F)c(C(=O)N(C)C)c2)C1 to have a higher LogP value.,C[C@@H]1CCC[C@H](CC(=O)Nc2ccc(F)c(C(=O)N(C)C)c2)C1,3.682400000000002
+810,Modify the molecule O=C(Nc1ccccc1)NC1CCN(C(=O)[C@H]2CCCC[C@H]2C(F)(F)F)CC1 to have a higher LogP value.,O=C(Nc1ccccc1)NC1CCN(C(=O)[C@H]2CCCC[C@H]2C(F)(F)F)CC1,4.167800000000004
+92203,Modify the molecule Cc1cc(Cl)ccc1NC(=O)C(=O)NCc1ccccc1C[NH+](C)C to decrease its LogP value.,Cc1cc(Cl)ccc1NC(=O)C(=O)NCc1ccccc1C[NH+](C)C,1.5478199999999993
+206572,Optimize the molecule COC[C@@H](O)CN(C)c1ccc(C(N)=O)nn1 to have a lower LogP value.,COC[C@@H](O)CN(C)c1ccc(C(N)=O)nn1,-0.9809999999999992
+248529,Modify the molecule O=C(Nc1cc([N+](=O)[O-])ccc1Cl)c1nc[nH]n1 to decrease its LogP value.,O=C(Nc1cc([N+](=O)[O-])ccc1Cl)c1nc[nH]n1,1.6185999999999996
+10043,Modify the molecule O=C([C@H](O)c1ccccc1Cl)N1CCN(c2ccccc2Cl)C(=O)C1 to increase its LogP value.,O=C([C@H](O)c1ccccc1Cl)N1CCN(c2ccccc2Cl)C(=O)C1,2.9022000000000014
+208585,Please optimize the molecule COc1cc([C@@H]2CN(C(=O)c3ccccc3)C[C@H]2C(=O)NC(C)C)cc(OC)c1OC to have a higher LogP value.,COc1cc([C@@H]2CN(C(=O)c3ccccc3)C[C@H]2C(=O)NC(C)C)cc(OC)c1OC,3.0928000000000013
+173827,Please optimize the molecule CO[C@H](CNC(=O)NC[C@@H](O)c1ccc(F)cc1)c1cccc(Cl)c1 to have a higher LogP value.,CO[C@H](CNC(=O)NC[C@@H](O)c1ccc(F)cc1)c1cccc(Cl)c1,3.1994000000000016
+149142,Please modify the molecule CCc1nc(C)c([C@@H](C)[NH2+]Cc2c(CC)nn(C)c2CC)s1 to increase its LogP value.,CCc1nc(C)c([C@@H](C)[NH2+]Cc2c(CC)nn(C)c2CC)s1,2.6968200000000007
+177127,Please optimize the molecule COc1ccccc1S(=O)(=O)C[C@@H]1CCC[NH2+]1 to have a higher LogP value.,COc1ccccc1S(=O)(=O)C[C@@H]1CCC[NH2+]1,0.19470000000000043
+154586,Optimize the molecule CCN1CC[NH+]([C@@H](c2ccc(Br)cc2)c2sc3nc(C)nn3c2[O-])CC1 to have a lower LogP value.,CCN1CC[NH+]([C@@H](c2ccc(Br)cc2)c2sc3nc(C)nn3c2[O-])CC1,1.2451200000000002
+96301,Please modify the molecule COc1ccc(S(=O)(=O)N(C2CC2)[C@@H](C)C2CC2)cc1OC to decrease its LogP value.,COc1ccc(S(=O)(=O)N(C2CC2)[C@@H](C)C2CC2)cc1OC,2.655400000000001
+68965,Modify the molecule CC(C)C(=O)N1CCC(NC(=O)C2(c3cccc(Cl)c3)CC2)CC1 to have a higher LogP value.,CC(C)C(=O)N1CCC(NC(=O)C2(c3cccc(Cl)c3)CC2)CC1,3.134800000000001
+184234,Please modify the molecule CC(C)CC[C@H]1CCCN(C(=O)C(=O)Nc2ccc(C(N)=O)cc2F)C1 to increase its LogP value.,CC(C)CC[C@H]1CCCN(C(=O)C(=O)Nc2ccc(C(N)=O)cc2F)C1,2.5379000000000005
+134012,Modify the molecule Cc1cc(F)ccc1[C@H](O)C1(C[NH3+])CCOCC1 to increase its LogP value.,Cc1cc(F)ccc1[C@H](O)C1(C[NH3+])CCOCC1,1.20622
+109591,Please modify the molecule COc1ccccc1CNC(=O)N1CCN([C@H](C)C(=O)NC2CC2)CC1 to increase its LogP value.,COc1ccccc1CNC(=O)N1CCN([C@H](C)C(=O)NC2CC2)CC1,1.1895
+52861,Please optimize the molecule CCc1ccc(C(C)(C)NC(=O)C2CCN(C(=O)c3ccoc3)CC2)cc1 to have a lower LogP value.,CCc1ccc(C(C)(C)NC(=O)C2CCN(C(=O)c3ccoc3)CC2)cc1,3.745700000000003
+241240,Please optimize the molecule COc1ccc(CN(C(=O)c2nc3nccc(C)n3n2)[C@H](C)C2CC2)cc1 to have a lower LogP value.,COc1ccc(CN(C(=O)c2nc3nccc(C)n3n2)[C@H](C)C2CC2)cc1,2.882220000000001
+113425,Please optimize the molecule C[C@@H]([NH2+]Cc1ccc(-n2ccnc2)cc1)c1cccnc1 to have a lower LogP value.,C[C@@H]([NH2+]Cc1ccc(-n2ccnc2)cc1)c1cccnc1,2.0919
+110477,Optimize the molecule COC(=O)/C=C/Sc1ccc(C(F)(F)F)cc1N to have a lower LogP value.,COC(=O)/C=C/Sc1ccc(C(F)(F)F)cc1N,3.0664000000000007
+19408,Please optimize the molecule Cc1ccc(N2CCC(C(=O)NCc3ccc[nH]3)CC2)[nH+]c1 to have a higher LogP value.,Cc1ccc(N2CCC(C(=O)NCc3ccc[nH]3)CC2)[nH+]c1,1.6700199999999996
+82776,Optimize the molecule CN(Cc1cc(Cl)cn1C)C(=O)NCc1ccnc(OC2CCC2)c1 to have a higher LogP value.,CN(Cc1cc(Cl)cn1C)C(=O)NCc1ccnc(OC2CCC2)c1,3.346400000000002
+145307,Please modify the molecule CC[C@H](NC(=O)N[C@@H]1CCCc2c1cnn2C)c1cccs1 to increase its LogP value.,CC[C@H](NC(=O)N[C@@H]1CCCc2c1cnn2C)c1cccs1,3.3095000000000017
+62856,Optimize the molecule Cc1ccncc1NC(=O)N1CCC2(C1)OCCO2 to have a higher LogP value.,Cc1ccncc1NC(=O)N1CCC2(C1)OCCO2,1.3707199999999997
+180601,Optimize the molecule C1CCN(c2nc(NC3CCCC3)nc3n[nH]nc23)CC1 to have a lower LogP value.,C1CCN(c2nc(NC3CCCC3)nc3n[nH]nc23)CC1,2.0927
+91767,Modify the molecule COc1ccc(C(=O)N[C@H](C(=O)NCc2cccnc2)C(C)C)cc1 to have a higher LogP value.,COc1ccc(C(=O)N[C@H](C(=O)NCc2cccnc2)C(C)C)cc1,2.1609999999999996
+188174,Please modify the molecule C[NH+](C)CCN(Cc1cccs1)C(=O)c1cc(Cl)c2c(c1)OCO2 to increase its LogP value.,C[NH+](C)CCN(Cc1cccs1)C(=O)c1cc(Cl)c2c(c1)OCO2,1.9171000000000002
+85647,Optimize the molecule O=C([O-])c1ccc(C(F)(F)F)nc1NC[C@@H]1CCOC1 to have a lower LogP value.,O=C([O-])c1ccc(C(F)(F)F)nc1NC[C@@H]1CCOC1,0.9122999999999999
+210269,Please optimize the molecule CCS(=O)(=O)N(C)C1CCN(C(=O)[C@@H]2CCO[C@@H]2C)CC1 to have a higher LogP value.,CCS(=O)(=O)N(C)C1CCN(C(=O)[C@@H]2CCO[C@@H]2C)CC1,0.6839000000000008
+186479,Modify the molecule COC[C@H]([NH2+]C1CCN(C(=O)[C@@H]2COc3ccccc3O2)CC1)C(C)C to have a higher LogP value.,COC[C@H]([NH2+]C1CCN(C(=O)[C@@H]2COc3ccccc3O2)CC1)C(C)C,1.051800000000002
+174207,Please optimize the molecule Cc1cc(NC(=O)CN2CCN(C(=O)[C@@H](C)Sc3cc(Cl)ccc3Cl)CC2)no1 to have a higher LogP value.,Cc1cc(NC(=O)CN2CCN(C(=O)[C@@H](C)Sc3cc(Cl)ccc3Cl)CC2)no1,3.553320000000002
+55027,Optimize the molecule Cc1ccc(C)c(-c2cc(C(=O)[O-])c3cc(C)ccc3n2)c1 to have a lower LogP value.,Cc1ccc(C)c(-c2cc(C(=O)[O-])c3cc(C)ccc3n2)c1,3.1905600000000014
+114133,Modify the molecule O=C(c1csc(-c2ccccc2)n1)N1CCC(Cn2cc[nH+]c2)CC1 to increase its LogP value.,O=C(c1csc(-c2ccccc2)n1)N1CCC(Cn2cc[nH+]c2)CC1,2.9781000000000004
+176782,Modify the molecule Cc1c(O)ccc2c(C[NH+]3CCC(C)CC3)cc(=O)oc12 to have a higher LogP value.,Cc1c(O)ccc2c(C[NH+]3CCC(C)CC3)cc(=O)oc12,1.62182
+187382,Modify the molecule N#Cc1ccc(NC(=O)[C@H]2CC(=O)N(Cc3ccccn3)C2)cc1 to have a lower LogP value.,N#Cc1ccc(NC(=O)[C@H]2CC(=O)N(Cc3ccccn3)C2)cc1,1.9404799999999998
+241468,Modify the molecule CCn1c(SCc2nccn2C)nc2sc(C)c(C)c2c1=O to have a higher LogP value.,CCn1c(SCc2nccn2C)nc2sc(C)c(C)c2c1=O,3.120540000000002
+22471,Please optimize the molecule CCOc1ccc(C(=O)N(C)[C@H](C)c2ccc(-n3cncn3)cc2)cc1 to have a higher LogP value.,CCOc1ccc(C(=O)N(C)[C@H](C)c2ccc(-n3cncn3)cc2)cc1,3.499200000000002
+233014,Please modify the molecule C=CCN(C(=O)[C@@H]1CCCN1S(C)(=O)=O)c1nc2ccccc2s1 to increase its LogP value.,C=CCN(C(=O)[C@@H]1CCCN1S(C)(=O)=O)c1nc2ccccc2s1,2.2393
+14686,Please modify the molecule COC[C@H](C)C(=O)NC[C@H]1C[C@H](O)C[NH+]1Cc1ccccc1 to increase its LogP value.,COC[C@H](C)C(=O)NC[C@H]1C[C@H](O)C[NH+]1Cc1ccccc1,-0.39659999999999673
+4704,Please modify the molecule CC(C)CNC(=O)[C@H](C)[NH+]1CCC[C@@H]1[C@@H]1CCCCC1=O to increase its LogP value.,CC(C)CNC(=O)[C@H](C)[NH+]1CCC[C@@H]1[C@@H]1CCCCC1=O,0.9537000000000011
+63212,Optimize the molecule CC(C)[C@@H](CO)NC(=O)NCCNC(=O)c1ccc(F)cc1 to have a higher LogP value.,CC(C)[C@@H](CO)NC(=O)NCCNC(=O)c1ccc(F)cc1,0.8716
+172690,Modify the molecule O=C([O-])CNC(=O)/C=C/c1c(Cl)cccc1Cl to have a higher LogP value.,O=C([O-])CNC(=O)/C=C/c1c(Cl)cccc1Cl,0.8727
+143010,Modify the molecule C[C@@H]1CSC(=O)N1CCC(=O)OCC1=NC(=O)[C@H]2SC=CC2=N1 to have a lower LogP value.,C[C@@H]1CSC(=O)N1CCC(=O)OCC1=NC(=O)[C@H]2SC=CC2=N1,1.4858
+44259,Optimize the molecule CCc1cccc(C)c1NC(=O)[C@H](CC)n1nc(C)c2sc3ccccc3c2c1=O to have a higher LogP value.,CCc1cccc(C)c1NC(=O)[C@H](CC)n1nc(C)c2sc3ccccc3c2c1=O,5.380240000000005
+236427,Please optimize the molecule Cc1cccc(C(C)(C)NC(=O)CCSc2nc(C)n[nH]2)c1 to have a lower LogP value.,Cc1cccc(C(C)(C)NC(=O)CCSc2nc(C)n[nH]2)c1,2.9552400000000008
+150457,Please optimize the molecule NC(=O)c1ccc(Oc2nccnc2[C@H]2CCCN(Cc3ccccn3)C2)cc1 to have a higher LogP value.,NC(=O)c1ccc(Oc2nccnc2[C@H]2CCCN(Cc3ccccn3)C2)cc1,3.142400000000002
+237469,Please optimize the molecule Cc1n[nH]c2cc(NC(=O)CCN3C(=O)COc4ccccc43)ccc12 to have a higher LogP value.,Cc1n[nH]c2cc(NC(=O)CCN3C(=O)COc4ccccc43)ccc12,2.6255200000000007
+195478,Modify the molecule C[C@H]1C[NH2+]CCN1C1CCCCC1 to decrease its LogP value.,C[C@H]1C[NH2+]CCN1C1CCCCC1,0.5866000000000002
+168319,Modify the molecule O=C(Nc1cccc(C[NH+]2CCCC2)c1)c1n[nH]c2ccccc12 to increase its LogP value.,O=C(Nc1cccc(C[NH+]2CCCC2)c1)c1n[nH]c2ccccc12,1.9938999999999991
+22235,Modify the molecule O=C1S/C(=C\c2ccc3c(c2)OCO3)C(=O)N1CNc1cccc(Cl)c1 to have a higher LogP value.,O=C1S/C(=C\c2ccc3c(c2)OCO3)C(=O)N1CNc1cccc(Cl)c1,4.174600000000002
+52258,Modify the molecule C[C@@H](NC(=O)c1csnn1)c1ccc(OCc2cccnc2)cc1 to have a lower LogP value.,C[C@@H](NC(=O)c1csnn1)c1ccc(OCc2cccnc2)cc1,3.0031000000000017
+68248,Please optimize the molecule CCCc1cc(NCCn2cccn2)n2ncnc2n1 to have a lower LogP value.,CCCc1cc(NCCn2cccn2)n2ncnc2n1,1.3853999999999997
+63944,Modify the molecule Cc1cc(C)cc(CS(=O)(=O)Cc2ccc(F)cc2)c1 to have a higher LogP value.,Cc1cc(C)cc(CS(=O)(=O)Cc2ccc(F)cc2)c1,3.557540000000002
+246660,Optimize the molecule COC(=O)Cn1cc(/C=C2/C(=O)NC(=O)N(c3ccccc3)C2=O)c2ccccc21 to have a higher LogP value.,COC(=O)Cn1cc(/C=C2/C(=O)NC(=O)N(c3ccccc3)C2=O)c2ccccc21,2.4807000000000006
+77515,Modify the molecule C[C@@H]1CC(C)(C)C[C@]2(C1)NC(=O)N(CC(=O)Oc1cccc(Cl)c1)C2=O to have a lower LogP value.,C[C@@H]1CC(C)(C)C[C@]2(C1)NC(=O)N(CC(=O)Oc1cccc(Cl)c1)C2=O,3.382200000000002
+142650,Modify the molecule CCc1ccc([C@@H](C)NC(=O)Nc2cccc(OC[C@H]3CCCO3)c2)cc1 to have a higher LogP value.,CCc1ccc([C@@H](C)NC(=O)Nc2cccc(OC[C@H]3CCCO3)c2)cc1,4.689500000000003
+161674,Modify the molecule Cc1ccc(NC(=O)[C@H]2CCCN(c3ccc(-n4ccnc4)nn3)C2)cc1 to have a higher LogP value.,Cc1ccc(NC(=O)[C@H]2CCCN(c3ccc(-n4ccnc4)nn3)C2)cc1,2.825820000000001
+47294,Please modify the molecule Cc1ccccc1NC(=O)c1c(F)c(F)cc(F)c1F to decrease its LogP value.,Cc1ccccc1NC(=O)c1c(F)c(F)cc(F)c1F,3.803720000000001
+28997,Please optimize the molecule C[C@@H]1C[NH+]2CCC[C@@H]2CN1c1ccc(N)cc1 to have a lower LogP value.,C[C@@H]1C[NH+]2CCC[C@@H]2CN1c1ccc(N)cc1,0.5246000000000005
+188273,Modify the molecule Cc1ccc(Cl)c2sc(N(CCCN3CCOCC3)C(=O)c3cnccn3)nc12 to have a higher LogP value.,Cc1ccc(Cl)c2sc(N(CCCN3CCOCC3)C(=O)c3cnccn3)nc12,3.4172200000000013
+245321,Optimize the molecule CC(C)(O)CCOc1ccc2c(c1)OC(C)(C)C[C@H]2[NH3+] to have a higher LogP value.,CC(C)(O)CCOc1ccc2c(c1)OC(C)(C)C[C@H]2[NH3+],2.0705
+48072,Optimize the molecule CO[C@H](CNCc1cc2ccccc2[nH]c1=O)c1ccccc1 to have a lower LogP value.,CO[C@H](CNCc1cc2ccccc2[nH]c1=O)c1ccccc1,3.0054000000000007
+92820,Please modify the molecule CC(=O)Nc1ccc(C)cc1S(=O)(=O)N1CCC(c2nnc(C(=O)Nc3ccccc3)s2)CC1 to increase its LogP value.,CC(=O)Nc1ccc(C)cc1S(=O)(=O)N1CCC(c2nnc(C(=O)Nc3ccccc3)s2)CC1,3.6255200000000025
+234590,Modify the molecule CC(C)[C@H](C)NC(=O)[C@@H](Cc1ccccc1)NC(=O)c1ccccc1 to have a higher LogP value.,CC(C)[C@H](C)NC(=O)[C@@H](Cc1ccccc1)NC(=O)c1ccccc1,3.1884000000000015
+136003,Modify the molecule C[C@H](Nc1ccccc1OC(F)(F)F)C1CC[NH+](C)CC1 to increase its LogP value.,C[C@H](Nc1ccccc1OC(F)(F)F)C1CC[NH+](C)CC1,2.3103
+51847,Optimize the molecule CC(=O)c1cccc(S(=O)(=O)Nc2ccc3c(c2)N(C(=O)C(C)(C)C)CC3)c1 to have a lower LogP value.,CC(=O)c1cccc(S(=O)(=O)Nc2ccc3c(c2)N(C(=O)C(C)(C)C)CC3)c1,3.625200000000002
+53125,Please modify the molecule CCOc1ccc(NC(=O)/C=C/c2ccc([N+](=O)[O-])cc2)c([N+](=O)[O-])c1 to decrease its LogP value.,CCOc1ccc(NC(=O)/C=C/c2ccc([N+](=O)[O-])cc2)c([N+](=O)[O-])c1,3.553600000000002
+116141,Please optimize the molecule Cc1cc(C(=O)N2CCN(C(=O)CCc3c(C)n[nH]c3C)CC2)c(C)o1 to have a lower LogP value.,Cc1cc(C(=O)N2CCN(C(=O)CCc3c(C)n[nH]c3C)CC2)c(C)o1,2.15358
+140770,Modify the molecule Cc1ccc(C(=O)NCC(=O)N2CC=C(c3ccccc3)CC2)s1 to have a higher LogP value.,Cc1ccc(C(=O)NCC(=O)N2CC=C(c3ccccc3)CC2)s1,3.1022200000000018
+1592,Modify the molecule COC(=O)c1cc([C@@H]2CC(=O)Nc3c2c(C(C)(C)C)nn3C)ccc1O to decrease its LogP value.,COC(=O)c1cc([C@@H]2CC(=O)Nc3c2c(C(C)(C)C)nn3C)ccc1O,2.6839000000000017
+242076,Please modify the molecule CCn1nccc1[C@@H](C)[NH2+]Cc1cc(-c2cccs2)n[nH]1 to decrease its LogP value.,CCn1nccc1[C@@H](C)[NH2+]Cc1cc(-c2cccs2)n[nH]1,2.1792000000000002
+54498,Please optimize the molecule O=C(Nc1ccccc1Cl)c1ccc(-n2cccn2)nn1 to have a lower LogP value.,O=C(Nc1ccccc1Cl)c1ccc(-n2cccn2)nn1,2.5680000000000005
+245263,Optimize the molecule COc1cc(C2(C(=O)Nc3ccc(C(=O)N(C)C)c(C)c3)CC2)ccc1C to have a higher LogP value.,COc1cc(C2(C(=O)Nc3ccc(C(=O)N(C)C)c(C)c3)CC2)ccc1C,3.684140000000003
+65302,Please optimize the molecule C[C@@H]1CC[C@H]([NH3+])[C@H](C(=O)NC[C@@H]2CN3CCC[C@@H]3CO2)C1 to have a higher LogP value.,C[C@@H]1CC[C@H]([NH3+])[C@H](C(=O)NC[C@@H]2CN3CCC[C@@H]3CO2)C1,0.012500000000001954
+146098,Modify the molecule C/[NH+]=C(/NC[C@@H]1CCO[C@@H]1c1ccccc1)N1CC[C@H](c2ccccc2)C1 to increase its LogP value.,C/[NH+]=C(/NC[C@@H]1CCO[C@@H]1c1ccccc1)N1CC[C@H](c2ccccc2)C1,1.9097000000000004
+3913,Optimize the molecule COC(=O)[C@@H]1CCCC[C@H]1NC(=O)c1cc(Cl)c(OC)c(Cl)c1 to have a lower LogP value.,COC(=O)[C@@H]1CCCC[C@H]1NC(=O)c1cc(Cl)c(OC)c(Cl)c1,3.4636000000000022
+117737,Modify the molecule [NH3+]C[C@@H]1CC[C@H](C(=O)OCc2ccccc2Cl)O1 to increase its LogP value.,[NH3+]C[C@@H]1CC[C@H](C(=O)OCc2ccccc2Cl)O1,1.1727000000000005
+184305,Please modify the molecule COC(=O)[C@]1(C)CCN(C(=O)Nc2cnc(-c3ccccc3)s2)C1 to decrease its LogP value.,COC(=O)[C@]1(C)CCN(C(=O)Nc2cnc(-c3ccccc3)s2)C1,3.227000000000001
+63537,Modify the molecule O=C(Cc1ccc(F)cc1)O[C@@H](c1ccccc1)c1ccccn1 to increase its LogP value.,O=C(Cc1ccc(F)cc1)O[C@@H](c1ccccc1)c1ccccn1,4.096000000000003
+72396,Please modify the molecule Cc1cc(CN2C(=O)[C@H]3CCCN3C(=O)[C@@H]2C)on1 to increase its LogP value.,Cc1cc(CN2C(=O)[C@H]3CCCN3C(=O)[C@@H]2C)on1,0.70472
+248027,Modify the molecule C[C@H](OCc1ccccc1)C(=O)Nc1ccc2c(c1)oc(=O)n2C to have a higher LogP value.,C[C@H](OCc1ccccc1)C(=O)Nc1ccc2c(c1)oc(=O)n2C,2.675300000000001
+181835,Optimize the molecule COc1ccc(S(=O)(=O)[N-]c2ccc(F)cc2C)c([N+](=O)[O-])c1 to have a higher LogP value.,COc1ccc(S(=O)(=O)[N-]c2ccc(F)cc2C)c([N+](=O)[O-])c1,3.445020000000002
+153733,Please optimize the molecule Cc1ccc(F)cc1NS(=O)(=O)c1ccc2c(c1)CCCC2 to have a lower LogP value.,Cc1ccc(F)cc1NS(=O)(=O)c1ccc2c(c1)CCCC2,3.8137200000000027
+9065,Optimize the molecule Cc1n[nH]c([C@H]2CN(CCCn3c(=O)oc4ccccc43)CCO2)n1 to have a lower LogP value.,Cc1n[nH]c([C@H]2CN(CCCn3c(=O)oc4ccccc43)CCO2)n1,1.4846199999999998
+71054,Please modify the molecule Cc1cccc(C2=CCN(C(=O)/C=C/c3ccc(C(N)=O)cc3)CC2)c1 to increase its LogP value.,Cc1cccc(C2=CCN(C(=O)/C=C/c3ccc(C(N)=O)cc3)CC2)c1,3.423020000000001
+186272,Please modify the molecule COc1ccccc1N1CCN(CC(=O)Nc2sc3c(c2C(N)=O)CCC3)CC1 to decrease its LogP value.,COc1ccccc1N1CCN(CC(=O)Nc2sc3c(c2C(N)=O)CCC3)CC1,2.1049999999999995
+6192,Please modify the molecule CCS(=O)(=O)CC(=O)OCc1ccc([N+](=O)[O-])cc1 to increase its LogP value.,CCS(=O)(=O)CC(=O)OCc1ccc([N+](=O)[O-])cc1,1.0726999999999998
+215162,Please optimize the molecule Cn1nc(NC(=O)c2ccccc2)c2c1NC(=O)C[C@H]2c1ccco1 to have a higher LogP value.,Cn1nc(NC(=O)c2ccccc2)c2c1NC(=O)C[C@H]2c1ccco1,2.7395000000000005
+141498,Optimize the molecule O=C(N[C@H]1CC=NN1C1CC[NH+](C[C@@H]2C=CN=N2)CC1)c1ccccc1 to have a higher LogP value.,O=C(N[C@H]1CC=NN1C1CC[NH+](C[C@@H]2C=CN=N2)CC1)c1ccccc1,0.829400000000001
+99573,Please modify the molecule COc1cc(C[NH2+][C@@H]2CCC[C@H](C)C2)ccc1OCc1ccncc1 to increase its LogP value.,COc1cc(C[NH2+][C@@H]2CCC[C@H](C)C2)ccc1OCc1ccncc1,3.311300000000002
+2546,Modify the molecule COc1ccc(C[NH+]2CCc3nnc([C@@H](C)NC(=O)C(C)C)n3CC2)cc1OC to increase its LogP value.,COc1ccc(C[NH+]2CCc3nnc([C@@H](C)NC(=O)C(C)C)n3CC2)cc1OC,0.7697000000000009
+161922,Please optimize the molecule COc1cc(C[NH+](C)[C@@H]2CC(=O)N(c3ccc(F)cc3)C2=O)ccc1O to have a higher LogP value.,COc1cc(C[NH+](C)[C@@H]2CC(=O)N(c3ccc(F)cc3)C2=O)ccc1O,0.8866999999999996
+207495,Optimize the molecule C[C@H]1CC[NH+](CCC(=O)NCc2ccccc2Cl)C[C@@H]1O to have a lower LogP value.,C[C@H]1CC[NH+](CCC(=O)NCc2ccccc2Cl)C[C@@H]1O,0.6319000000000001
+160344,Optimize the molecule Cc1csc(NC(=O)N2CCC[C@H](c3nc4ccccc4o3)C2)n1 to have a higher LogP value.,Cc1csc(NC(=O)N2CCC[C@H](c3nc4ccccc4o3)C2)n1,4.004220000000003
+2142,Please modify the molecule Cc1ccc([C@@]23CCC(=O)N2CCC[NH2+]3)cc1 to increase its LogP value.,Cc1ccc([C@@]23CCC(=O)N2CCC[NH2+]3)cc1,0.7373199999999999
+191746,Please optimize the molecule COC(=O)c1ccc(/C=c2\s/c(=C(/C#N)C(=O)NC3CC3)n(-c3ccccc3)c2=O)cc1 to have a higher LogP value.,COC(=O)c1ccc(/C=c2\s/c(=C(/C#N)C(=O)NC3CC3)n(-c3ccccc3)c2=O)cc1,1.4672799999999997
+129283,Please modify the molecule O=C(NCCS(=O)(=O)c1ccccc1)N[C@H]1CC=CCC1 to increase its LogP value.,O=C(NCCS(=O)(=O)c1ccccc1)N[C@H]1CC=CCC1,1.8682
+92848,Please optimize the molecule CC(C)[C@@H]([NH2+]Cc1cccnc1)c1ccc2c(c1)CCO2 to have a higher LogP value.,CC(C)[C@@H]([NH2+]Cc1cccnc1)c1ccc2c(c1)CCO2,2.4772
+241986,Modify the molecule COc1cccc(F)c1[C@H](C)NC(=O)N(CCO)Cc1ccccc1 to have a lower LogP value.,COc1cccc(F)c1[C@H](C)NC(=O)N(CCO)Cc1ccccc1,3.099400000000002
+79178,Modify the molecule Cc1ccc(C#N)c(Nn2c(C)ccc2C)n1 to have a higher LogP value.,Cc1ccc(C#N)c(Nn2c(C)ccc2C)n1,2.5552400000000004
+188312,Optimize the molecule CC(C)[C@H](C)[NH2+]CC1CCS(=O)(=O)CC1 to have a higher LogP value.,CC(C)[C@H](C)[NH2+]CC1CCS(=O)(=O)CC1,0.4191000000000009
+187906,Please modify the molecule CC(=O)c1cccc(S(=O)(=O)N(C)CC(N)=O)c1 to decrease its LogP value.,CC(=O)c1cccc(S(=O)(=O)N(C)CC(N)=O)c1,-0.0050000000000000044
+123691,Please modify the molecule C[C@H]1C[C@@H](C)CN(C(=O)c2ccccc2NC(=O)[C@@H](C)c2ccc3c(c2)OCCO3)C1 to decrease its LogP value.,C[C@H]1C[C@@H](C)CN(C(=O)c2ccccc2NC(=O)[C@@H](C)c2ccc3c(c2)OCCO3)C1,4.318100000000004
+65143,Modify the molecule CCCCC(=O)NC(=S)Nc1ccc(C)c(C)c1 to have a lower LogP value.,CCCCC(=O)NC(=S)Nc1ccc(C)c(C)c1,3.3066400000000016
+173429,Please modify the molecule O=C(Nc1cc2c3c(c1)CC(=O)N3CCC2)c1ccc(F)c(F)c1 to increase its LogP value.,O=C(Nc1cc2c3c(c1)CC(=O)N3CCC2)c1ccc(F)c(F)c1,3.0524000000000013
+176051,Modify the molecule CCCC(=O)N(CCN1CCOCC1)c1nc2c(C)ccc(C)c2s1 to have a lower LogP value.,CCCC(=O)N(CCN1CCOCC1)c1nc2c(C)ccc(C)c2s1,3.378440000000002
+55973,Please modify the molecule C[C@H]1CN(CCC(=O)[O-])S(=O)(=O)C1 to decrease its LogP value.,C[C@H]1CN(CCC(=O)[O-])S(=O)(=O)C1,-1.5920999999999985
+105877,Modify the molecule C[C@@H](N[C@@H](CCC#N)c1ccccc1)c1ccc(F)c(Cl)c1 to have a lower LogP value.,C[C@@H](N[C@@H](CCC#N)c1ccccc1)c1ccc(F)c(Cl)c1,5.174780000000004
+13117,Modify the molecule O=C([O-])/C(=C/c1ccsc1)c1ccccc1 to have a lower LogP value.,O=C([O-])/C(=C/c1ccsc1)c1ccccc1,2.0385999999999997
+245303,Please modify the molecule Cc1ccccc1C(=O)NNc1ncnc(N(C)C)c1N to decrease its LogP value.,Cc1ccccc1C(=O)NNc1ncnc(N(C)C)c1N,1.19012
+248909,Optimize the molecule O=C(N1CCN(C(c2ccccc2)c2ccccc2)CC1)C1(n2cnnn2)CCCCC1 to have a higher LogP value.,O=C(N1CCN(C(c2ccccc2)c2ccccc2)CC1)C1(n2cnnn2)CCCCC1,3.266300000000002
+25044,Please optimize the molecule CCOC(=O)C1CCC([NH+](C)C2CCS(=O)(=O)CC2)CC1 to have a higher LogP value.,CCOC(=O)C1CCC([NH+](C)C2CCS(=O)(=O)CC2)CC1,0.20020000000000215
+144916,Optimize the molecule Cc1csc(S(=O)(=O)CC(=O)N[C@H]2CCCC[C@H]2C)n1 to have a higher LogP value.,Cc1csc(S(=O)(=O)CC(=O)N[C@H]2CCCC[C@H]2C)n1,1.92012
+45462,Please optimize the molecule Cc1[nH]ncc1C(=O)NC[C@H](c1ccccc1)[NH+]1CCCC1 to have a higher LogP value.,Cc1[nH]ncc1C(=O)NC[C@H](c1ccccc1)[NH+]1CCCC1,0.8679199999999991
+172500,Please modify the molecule CC(=O)N1CCC(NC(=O)c2c(C)nn(C)c2Cl)CC1 to increase its LogP value.,CC(=O)N1CCC(NC(=O)c2c(C)nn(C)c2Cl)CC1,1.12262
+109051,Modify the molecule C[C@@H](O)C[C@H]1CCC[NH+]1CCC(=O)N(C)CCC#N to have a lower LogP value.,C[C@@H](O)C[C@H]1CCC[NH+]1CCC(=O)N(C)CCC#N,-0.4332199999999984
+23556,Modify the molecule COc1ccc([C@@H]2C[C@@H]3C(=O)N=N[C@@H](SCC(=O)Nc4ccc(C)cc4Cl)N3N2)cc1OC to have a lower LogP value.,COc1ccc([C@@H]2C[C@@H]3C(=O)N=N[C@@H](SCC(=O)Nc4ccc(C)cc4Cl)N3N2)cc1OC,3.9335200000000023
+11764,Modify the molecule O=c1[nH]c([O-])nc(/C=C\C2=c3ccccc3=[NH+]C2)c1[N+](=O)[O-] to decrease its LogP value.,O=c1[nH]c([O-])nc(/C=C\C2=c3ccccc3=[NH+]C2)c1[N+](=O)[O-],-2.670399999999998
+140187,Modify the molecule CC[C@@H](C)[NH2+][C@H]1CSCC(C)(C)C1 to have a higher LogP value.,CC[C@@H](C)[NH2+][C@H]1CSCC(C)(C)C1,1.8800000000000001
+135050,Please modify the molecule C[C@@]1(C(=O)NCCn2cc[nH+]c2)Sc2ccccc2NC1=O to increase its LogP value.,C[C@@]1(C(=O)NCCn2cc[nH+]c2)Sc2ccccc2NC1=O,0.9214999999999993
+69738,Modify the molecule CN(Cc1ccccc1)C(=O)CNS(=O)(=O)c1ccc([N+](=O)[O-])cc1 to increase its LogP value.,CN(Cc1ccccc1)C(=O)CNS(=O)(=O)c1ccc([N+](=O)[O-])cc1,1.5317
+1275,Modify the molecule O[C@@H]1c2ccccc2C[C@H]1CCC(F)(F)F to increase its LogP value.,O[C@@H]1c2ccccc2C[C@H]1CCC(F)(F)F,3.2348000000000017
+114575,Please optimize the molecule COc1ccc(NC(=O)c2ccc(C#N)cc2F)c(OC)c1 to have a higher LogP value.,COc1ccc(NC(=O)c2ccc(C#N)cc2F)c(OC)c1,2.9668800000000015
+170019,Optimize the molecule Cc1ccccc1C(=O)N1CCC2(CC1)NC(=O)c1cccc(C)c1N2 to have a lower LogP value.,Cc1ccccc1C(=O)N1CCC2(CC1)NC(=O)c1cccc(C)c1N2,3.091240000000001
+157672,Modify the molecule CCC(=O)Nc1nc2ccc(NC(=O)N[C@@H](C)CC)cc2s1 to have a lower LogP value.,CCC(=O)Nc1nc2ccc(NC(=O)N[C@@H](C)CC)cc2s1,3.5648000000000017
+117322,Please optimize the molecule Cc1nc2ccn(Cc3cccnc3)c(=O)c2cc1C(=O)Nc1cccc(F)c1 to have a lower LogP value.,Cc1nc2ccn(Cc3cccnc3)c(=O)c2cc1C(=O)Nc1cccc(F)c1,3.539620000000002
+103608,Modify the molecule Cc1cc(C)c(C#N)c(Nc2cccnc2C)n1 to have a lower LogP value.,Cc1cc(C)c(C#N)c(Nc2cccnc2C)n1,3.0171400000000004
+183807,Modify the molecule C[C@@H]1[C@@H](C(=O)[O-])CCN1C(=O)N(CCO)C1CCCC1 to decrease its LogP value.,C[C@@H]1[C@@H](C(=O)[O-])CCN1C(=O)N(CCO)C1CCCC1,-0.19639999999999858
+191395,Please optimize the molecule CC(C)(C)OC(=O)c1c(F)ccc(C(=O)[O-])c1N to have a higher LogP value.,CC(C)(C)OC(=O)c1c(F)ccc(C(=O)[O-])c1N,0.7267000000000001
+44617,Optimize the molecule COc1ccc2c(c1)CCN(C(=O)[C@@H]1CCCN(C(=O)NCc3cccs3)C1)C2 to have a higher LogP value.,COc1ccc2c(c1)CCN(C(=O)[C@@H]1CCCN(C(=O)NCc3cccs3)C1)C2,3.263200000000002
+172635,Modify the molecule CC(=O)O[C@@H](C)C(=O)N1CCN(c2nccc(-c3ccc(C(C)(C)C)cc3)n2)CC1 to have a lower LogP value.,CC(=O)O[C@@H](C)C(=O)N1CCN(c2nccc(-c3ccc(C(C)(C)C)cc3)n2)CC1,3.0413000000000014
+70241,Optimize the molecule C[C@H]1CC[C@@]([NH3+])(Cc2nccs2)[C@H](C)C1 to have a higher LogP value.,C[C@H]1CC[C@@]([NH3+])(Cc2nccs2)[C@H](C)C1,2.1224
+124376,Please modify the molecule NC(=O)c1c(Cl)cccc1NCC(=O)N1CCC[C@H]2CCCC[C@H]21 to decrease its LogP value.,NC(=O)c1c(Cl)cccc1NCC(=O)N1CCC[C@H]2CCCC[C@H]21,3.032000000000002
+39006,Please modify the molecule O=C([O-])[C@H]1C[C@@H]1C(=O)Nc1ccc(I)cc1 to decrease its LogP value.,O=C([O-])[C@H]1C[C@@H]1C(=O)Nc1ccc(I)cc1,0.6156999999999999
+198647,Please modify the molecule COc1ccc(C2(C(=O)Nc3ccc(C(=O)N4CCCC4)cc3)CCOCC2)cc1 to increase its LogP value.,COc1ccc(C2(C(=O)Nc3ccc(C(=O)N4CCCC4)cc3)CCOCC2)cc1,3.6181000000000028
+75482,Modify the molecule C[C@H](NC(=O)c1ccc(Cl)nc1)c1nc(-c2ccncc2)n[nH]1 to have a lower LogP value.,C[C@H](NC(=O)c1ccc(Cl)nc1)c1nc(-c2ccncc2)n[nH]1,2.4060999999999995
+212624,Please modify the molecule O=S(=O)(CC1CCC1)[N-]c1cccc(-c2cn[nH]c2)c1 to increase its LogP value.,O=S(=O)(CC1CCC1)[N-]c1cccc(-c2cn[nH]c2)c1,3.211800000000002
+83178,Modify the molecule O=C(NCc1ccc(O)cc1)N1CCOC[C@@H]1C1CC1 to have a lower LogP value.,O=C(NCc1ccc(O)cc1)N1CCOC[C@@H]1C1CC1,1.7126000000000003
+3685,Optimize the molecule CC[C@@H](O)[C@@]1(C[NH3+])CCC[C@H](C)C1 to have a lower LogP value.,CC[C@@H](O)[C@@]1(C[NH3+])CCC[C@H](C)C1,1.1956999999999993
+19420,Modify the molecule O=C(Cn1cccc1-c1nc(-c2ccc(F)c(Br)c2)no1)NCc1ccccc1F to decrease its LogP value.,O=C(Cn1cccc1-c1nc(-c2ccc(F)c(Br)c2)no1)NCc1ccccc1F,4.5622000000000025
+158606,Modify the molecule Cc1cc(NC(=O)[C@@H]2Cc3ccccc3O2)no1 to have a higher LogP value.,Cc1cc(NC(=O)[C@@H]2Cc3ccccc3O2)no1,1.9252199999999997
+127487,Modify the molecule CCC[NH2+][C@H](c1cccc(C)c1)[C@H]1C[NH+]2CCN1CC2 to have a higher LogP value.,CCC[NH2+][C@H](c1cccc(C)c1)[C@H]1C[NH+]2CCN1CC2,-0.40777999999999714
+37648,Please modify the molecule CCN(CC(=O)NC)c1cncc(C(=O)OC)n1 to decrease its LogP value.,CCN(CC(=O)NC)c1cncc(C(=O)OC)n1,-0.16449999999999987
+13656,Please modify the molecule CCn1ncc(Br)c1C(=O)NCC(=O)C(C)(C)C to decrease its LogP value.,CCn1ncc(Br)c1C(=O)NCC(=O)C(C)(C)C,2.0105000000000004
+10441,Please optimize the molecule O=C(NNC(=O)c1cccc(NC(=O)c2ccco2)c1)c1ccncc1 to have a lower LogP value.,O=C(NNC(=O)c1cccc(NC(=O)c2ccco2)c1)c1ccncc1,2.0016999999999996
+175401,Please modify the molecule Cc1ccc(-n2nnnc2SCC(=O)Nc2ccnn2C2CCCC2)cc1C to increase its LogP value.,Cc1ccc(-n2nnnc2SCC(=O)Nc2ccnn2C2CCCC2)cc1C,3.3215400000000015
+163303,Please modify the molecule CC(=O)N[C@@H]1[C@@H](Oc2cccc([N+](=O)[O-])c2)O[C@@H]2COC(C)(C)O[C@@H]2[C@@H]1O to decrease its LogP value.,CC(=O)N[C@@H]1[C@@H](Oc2cccc([N+](=O)[O-])c2)O[C@@H]2COC(C)(C)O[C@@H]2[C@@H]1O,0.7155999999999993
+207089,Please modify the molecule CC(C)C[C@@H](C)[NH2+]Cc1ccc(F)c(Br)c1 to decrease its LogP value.,CC(C)C[C@@H](C)[NH2+]Cc1ccc(F)c(Br)c1,3.0862000000000007
+229630,Please optimize the molecule C[C@H](Nc1ccc(CC#N)cc1)c1ccoc1 to have a lower LogP value.,C[C@H](Nc1ccc(CC#N)cc1)c1ccoc1,3.5187800000000022
+221940,Modify the molecule COC(=O)C1=C(C)NC(=O)N[C@@H]1c1ccc(-c2ccccc2)cc1 to decrease its LogP value.,COC(=O)C1=C(C)NC(=O)N[C@@H]1c1ccc(-c2ccccc2)cc1,3.1545000000000014
+38729,Modify the molecule CN1/C(=C\C=C2\C(=N)N3N=C(C(F)(F)F)SC3=NC2=O)C(C)(C)c2ccccc21 to increase its LogP value.,CN1/C(=C\C=C2\C(=N)N3N=C(C(F)(F)F)SC3=NC2=O)C(C)(C)c2ccccc21,4.022370000000002
+82460,Please optimize the molecule Cc1noc(C)c1C[NH+](C)C[C@@H]1CC(C2CCCCC2)=NO1 to have a higher LogP value.,Cc1noc(C)c1C[NH+](C)C[C@@H]1CC(C2CCCCC2)=NO1,2.0313399999999997
+119623,Optimize the molecule COc1ccc(-c2noc(CCC(=O)Nc3ccccn3)n2)cc1OC to have a higher LogP value.,COc1ccc(-c2noc(CCC(=O)Nc3ccccn3)n2)cc1OC,2.7201000000000004
+46624,Modify the molecule Cn1cc(C[C@H]([NH3+])[C@H]2CSCCS2)cn1 to decrease its LogP value.,Cn1cc(C[C@H]([NH3+])[C@H]2CSCCS2)cn1,0.4217000000000002
+235417,Optimize the molecule CCc1csc([C@@H]2CCCN(C(=O)[C@@H]3CCO[C@@H]3C)C2)n1 to have a lower LogP value.,CCc1csc([C@@H]2CCCN(C(=O)[C@@H]3CCO[C@@H]3C)C2)n1,2.836500000000001
+218805,Please optimize the molecule CCc1ccc([C@@H](C)C(=O)N[C@H](CO)c2ccco2)cc1 to have a lower LogP value.,CCc1ccc([C@@H](C)C(=O)N[C@H](CO)c2ccco2)cc1,2.795300000000001
+219049,Please modify the molecule Cc1ccc(C2=NO[C@@H]3[C@H]4C[C@@H]([C@H]23)[C@H]2C(=O)N(c3ccccc3)C(=O)[C@H]42)cc1 to increase its LogP value.,Cc1ccc(C2=NO[C@@H]3[C@H]4C[C@@H]([C@H]23)[C@H]2C(=O)N(c3ccccc3)C(=O)[C@H]42)cc1,3.169620000000002
+164768,Optimize the molecule C[C@H]([NH2+]C[C@H](O)c1ccccc1)[C@@H](C)O to have a lower LogP value.,C[C@H]([NH2+]C[C@H](O)c1ccccc1)[C@@H](C)O,0.0526999999999998
+145985,Modify the molecule C[C@H](C(=O)NC1CC1)N1CCN(C(=O)NCc2cscn2)CC1 to increase its LogP value.,C[C@H](C(=O)NC1CC1)N1CCN(C(=O)NCc2cscn2)CC1,0.6374
+103373,Optimize the molecule CO[C@H]1CCCC[C@@H]1[NH2+]C1COC1 to have a higher LogP value.,CO[C@H]1CCCC[C@@H]1[NH2+]C1COC1,-0.09379999999999922
+142114,Optimize the molecule O=[N+]([O-])c1ccc(N2CC[NH+](Cc3nc(COc4ccc(F)cc4)no3)CC2)cc1 to have a higher LogP value.,O=[N+]([O-])c1ccc(N2CC[NH+](Cc3nc(COc4ccc(F)cc4)no3)CC2)cc1,1.600999999999999
+107014,Please modify the molecule CC[C@H]([NH2+]Cc1ccccn1)c1cc(C)ccc1OC to decrease its LogP value.,CC[C@H]([NH2+]Cc1ccccn1)c1cc(C)ccc1OC,2.6133200000000008
+229526,Modify the molecule COc1cccc([C@@H](c2c(C)nn(-c3ccccc3)c2O)c2c(C)[nH]n(-c3ccccc3)c2=O)c1 to have a lower LogP value.,COc1cccc([C@@H](c2c(C)nn(-c3ccccc3)c2O)c2c(C)[nH]n(-c3ccccc3)c2=O)c1,4.8625400000000045
+8247,Please optimize the molecule CC1(C)C([NH2+][C@H]2CC[C@H]([NH3+])C2)C1(C)C to have a higher LogP value.,CC1(C)C([NH2+][C@H]2CC[C@H]([NH3+])C2)C1(C)C,0.14740000000000086
+241057,Modify the molecule Cc1nc(C2=C(N)N(C(C)C)CC2=O)sc1C to have a lower LogP value.,Cc1nc(C2=C(N)N(C(C)C)CC2=O)sc1C,1.6803400000000002
+54303,Please optimize the molecule Cc1cc(C)cc(NC(=S)NC(=O)CC2CCCC2)c1 to have a lower LogP value.,Cc1cc(C)cc(NC(=S)NC(=O)CC2CCCC2)c1,3.696740000000002
+762,Modify the molecule CC1(C)[C@H]2OCC[C@@H]2[C@H]1NC(=O)CCNC(=O)C12CC3CC(CC(C3)C1)C2 to decrease its LogP value.,CC1(C)[C@H]2OCC[C@@H]2[C@H]1NC(=O)CCNC(=O)C12CC3CC(CC(C3)C1)C2,2.6388000000000007
+52511,Modify the molecule Cc1cc(=O)oc2cc(OCC(=O)Nc3ccc(OC(F)F)cc3)ccc12 to have a higher LogP value.,Cc1cc(=O)oc2cc(OCC(=O)Nc3ccc(OC(F)F)cc3)ccc12,3.720320000000002
+220157,Please modify the molecule Cc1nc(C)n(-c2ccc(C(=O)N3C[C@H]4[C@@H](C3)C4(C)C)cc2)n1 to decrease its LogP value.,Cc1nc(C)n(-c2ccc(C(=O)N3C[C@H]4[C@@H](C3)C4(C)C)cc2)n1,2.612140000000001
+110358,Please modify the molecule O=C([O-])CN1C(=O)c2ccccc2[C@@H]1O to increase its LogP value.,O=C([O-])CN1C(=O)c2ccccc2[C@@H]1O,-1.1168000000000007
+125733,Please optimize the molecule COc1cccc(C(=O)Nc2nc(C(C)=O)cs2)c1F to have a lower LogP value.,COc1cccc(C(=O)Nc2nc(C(C)=O)cs2)c1F,2.7457000000000003
+216801,Optimize the molecule Clc1cc(CN2CCc3cncnc3C2)cc2c1OCCO2 to have a lower LogP value.,Clc1cc(CN2CCc3cncnc3C2)cc2c1OCCO2,2.4595000000000002
+134608,Modify the molecule O=C([O-])[C@@H]1CCC(=O)N(CCCOC2CCCCC2)[C@H]1c1ccco1 to increase its LogP value.,O=C([O-])[C@@H]1CCC(=O)N(CCCOC2CCCCC2)[C@H]1c1ccco1,2.048599999999999
+87341,Optimize the molecule Cc1cccc(O[C@@H](C)C(=O)NNC(=O)c2cccs2)c1C to have a lower LogP value.,Cc1cccc(O[C@@H](C)C(=O)NNC(=O)c2cccs2)c1C,2.593440000000001
+175644,Please optimize the molecule O=C(CN1CCN(c2ccc(F)cc2)C1=O)Nc1ccc(Cl)cc1Cl to have a lower LogP value.,O=C(CN1CCN(c2ccc(F)cc2)C1=O)Nc1ccc(Cl)cc1Cl,4.013200000000003
+218410,Modify the molecule Cc1cccc(N)c1-c1nc2cccc(C)c2o1 to increase its LogP value.,Cc1cccc(N)c1-c1nc2cccc(C)c2o1,3.6938400000000025
+32467,Optimize the molecule COCCNC(=O)[C@]1(C[C@@H]2CC(c3ccc(F)cc3)=NO2)CCC[NH2+]C1 to have a higher LogP value.,COCCNC(=O)[C@]1(C[C@@H]2CC(c3ccc(F)cc3)=NO2)CCC[NH2+]C1,0.815000000000001
+4878,Optimize the molecule COc1ccc2c(c1)CCC/C2=N\OCC(=O)NCc1ccco1 to have a lower LogP value.,COc1ccc2c(c1)CCC/C2=N\OCC(=O)NCc1ccco1,2.661600000000001
+124186,Modify the molecule CCc1nnc(-c2cccn2CC(=O)NCc2ccc(C)cc2)o1 to have a lower LogP value.,CCc1nnc(-c2cccn2CC(=O)NCc2ccc(C)cc2)o1,2.725320000000001
+157886,Please optimize the molecule O=C(OCCN1CCCC1=O)[C@@H]1CCCN(C(=O)c2ccc(F)cc2)C1 to have a lower LogP value.,O=C(OCCN1CCCC1=O)[C@@H]1CCCN(C(=O)c2ccc(F)cc2)C1,1.8434999999999993
+185399,Please optimize the molecule Cc1cc(C)cc(NC(=O)[C@@H]2CSc3ncc(C)c(=O)n3C2)c1 to have a lower LogP value.,Cc1cc(C)cc(NC(=O)[C@@H]2CSc3ncc(C)c(=O)n3C2)c1,2.529160000000001
+209139,Modify the molecule COc1cccc2cc(C(=O)NC[C@@](C)(O)CCSC)oc12 to have a lower LogP value.,COc1cccc2cc(C(=O)NC[C@@](C)(O)CCSC)oc12,2.675300000000001
+229178,Modify the molecule CCCCN(C)C(=O)c1cn(Cc2cccnc2)nn1 to have a higher LogP value.,CCCCN(C)C(=O)c1cn(Cc2cccnc2)nn1,1.5935
+14946,Modify the molecule CCCNC(=O)c1cccc(C(=O)NNC(=O)c2cccc(C#N)c2)c1 to have a higher LogP value.,CCCNC(=O)c1cccc(C(=O)NNC(=O)c2cccc(C#N)c2)c1,1.7728799999999996
+18152,Modify the molecule Cc1noc(C)c1CCC(=O)N1CCC2(CC1)Nc1ccccc1S(=O)(=O)N2 to decrease its LogP value.,Cc1noc(C)c1CCC(=O)N1CCC2(CC1)Nc1ccccc1S(=O)(=O)N2,1.9467399999999997
+49996,Please optimize the molecule CCc1ccc(O)c(C(=O)N2CCN(Cc3nc(-c4cccc(C(F)(F)F)c4)no3)CC2)c1 to have a higher LogP value.,CCc1ccc(O)c(C(=O)N2CCN(Cc3nc(-c4cccc(C(F)(F)F)c4)no3)CC2)c1,3.9814000000000034
+109653,Modify the molecule O=C1Nc2ccccc2/C1=C\c1cccc(F)c1 to have a lower LogP value.,O=C1Nc2ccccc2/C1=C\c1cccc(F)c1,3.3184000000000013
+105514,Optimize the molecule Cc1ccc(OCc2ccc(C(=O)Nc3nc(CN4C[C@H](C)O[C@@H](C)C4)cs3)o2)cc1 to have a higher LogP value.,Cc1ccc(OCc2ccc(C(=O)Nc3nc(CN4C[C@H](C)O[C@@H](C)C4)cs3)o2)cc1,4.485020000000004
+187716,Please modify the molecule O=C1CCC[C@H]1CCOc1ccc(C(F)(F)F)cc1 to increase its LogP value.,O=C1CCC[C@H]1CCOc1ccc(C(F)(F)F)cc1,3.8435000000000032
+61988,Please modify the molecule C[C@H](c1ccccc1)[NH+]1CC[C@H](NC[C@](C)(O)c2ccco2)C1 to increase its LogP value.,C[C@H](c1ccccc1)[NH+]1CC[C@H](NC[C@](C)(O)c2ccco2)C1,1.4950999999999999
+193069,Optimize the molecule O=[N+]([O-])c1ccc(C2=NOc3cc(Cl)ccc3N2)cc1 to have a higher LogP value.,O=[N+]([O-])c1ccc(C2=NOc3cc(Cl)ccc3N2)cc1,3.4143000000000017
+157849,Optimize the molecule COc1ccc(-n2nnnc2SCC(=O)Nc2ccc(F)cc2)c(OC)c1 to have a lower LogP value.,COc1ccc(-n2nnnc2SCC(=O)Nc2ccc(F)cc2)c(OC)c1,2.5494000000000003
+137407,Please modify the molecule Cc1nc2c(s1)[C@H](N(C)C(=O)NCCn1cccc1)CCC2 to increase its LogP value.,Cc1nc2c(s1)[C@H](N(C)C(=O)NCCn1cccc1)CCC2,2.9720200000000014
+201069,Optimize the molecule C[C@@H]1CC(=O)Nc2ccccc2N1C(=O)COC(=O)C=C1CCCCC1 to have a higher LogP value.,C[C@@H]1CC(=O)Nc2ccccc2N1C(=O)COC(=O)C=C1CCCCC1,3.184000000000002
+200600,Modify the molecule CCC(CC)(NC(=O)Cc1c(F)cccc1F)/C(N)=N/O to have a lower LogP value.,CCC(CC)(NC(=O)Cc1c(F)cccc1F)/C(N)=N/O,1.9286999999999999
+235503,Please modify the molecule COc1cccc(-c2nnc(S[C@H](C)C(=O)Nc3cccc(C(F)(F)F)c3)n2C)c1 to decrease its LogP value.,COc1cccc(-c2nnc(S[C@H](C)C(=O)Nc3cccc(C(F)(F)F)c3)n2C)c1,4.628800000000004
+50593,Modify the molecule C[C@H](Nc1nc2c(N)cccc2o1)[C@H]1CCCO1 to decrease its LogP value.,C[C@H](Nc1nc2c(N)cccc2o1)[C@H]1CCCO1,2.3894
+84146,Please optimize the molecule CN(CCC#N)C(=O)CC[NH+]1CCC(N2CCC[C@H]2C(N)=O)CC1 to have a higher LogP value.,CN(CCC#N)C(=O)CC[NH+]1CCC(N2CCC[C@H]2C(N)=O)CC1,-1.2544199999999943
+238291,Optimize the molecule O=C(NCCc1ccc(F)cc1)c1ccc2c(=O)[nH][nH]c(=O)c2c1 to have a lower LogP value.,O=C(NCCc1ccc(F)cc1)c1ccc2c(=O)[nH][nH]c(=O)c2c1,1.3279999999999996
+107609,Optimize the molecule CC(C)C(=O)NC[C@@H]1CCCN(C(=O)[C@@H]2Cc3cc(F)ccc3O2)C1 to have a higher LogP value.,CC(C)C(=O)NC[C@@H]1CCCN(C(=O)[C@@H]2Cc3cc(F)ccc3O2)C1,2.1399999999999997
+105448,Modify the molecule Cc1nnsc1C(=O)Nc1nnc(-c2ccc(Cl)cc2)o1 to have a lower LogP value.,Cc1nnsc1C(=O)Nc1nnc(-c2ccc(Cl)cc2)o1,2.80222
+90107,Optimize the molecule CC[NH+]1CCC[C@H](NS(=O)(=O)C[C@@H](C)CCl)C1 to have a lower LogP value.,CC[NH+]1CCC[C@H](NS(=O)(=O)C[C@@H](C)CCl)C1,-0.15209999999999857
+246589,Please optimize the molecule Cc1cc2ncn(CC3CCN(C(=O)C(C)(C)CCl)CC3)c2cc1C to have a lower LogP value.,Cc1cc2ncn(CC3CCN(C(=O)C(C)(C)CCl)CC3)c2cc1C,4.156740000000004
+69756,Please optimize the molecule Cn1cc(S(=O)(=O)N2CCN(C(=O)Cc3ccccc3F)CC2)c(-c2cccnc2)n1 to have a higher LogP value.,Cn1cc(S(=O)(=O)N2CCN(C(=O)Cc3ccccc3F)CC2)c(-c2cccnc2)n1,1.6968
+58938,Modify the molecule O=C(CCC1CCCCC1)NNC(=O)C1CCC1 to have a lower LogP value.,O=C(CCC1CCCCC1)NNC(=O)C1CCC1,2.2944000000000004
+86904,Modify the molecule CCc1cnc(NC(=O)CNC(=O)c2ccccn2)s1 to have a higher LogP value.,CCc1cnc(NC(=O)CNC(=O)c2ccccn2)s1,1.4689999999999999
+245509,Please modify the molecule Cc1cc(C[NH2+]Cc2c(C)nn(C)c2C)cc(C)c1F to decrease its LogP value.,Cc1cc(C[NH2+]Cc2c(C)nn(C)c2C)cc(C)c1F,2.0564799999999996
+226570,Optimize the molecule CCN(CC(=O)N(C)C)C(=O)c1ccnc(N2CCCC[C@@H]2C)c1 to have a lower LogP value.,CCN(CC(=O)N(C)C)C(=O)c1ccnc(N2CCCC[C@@H]2C)c1,2.0107
+212412,Modify the molecule COc1ccc2c(c1)CCN(S(=O)(=O)CCNC(=O)c1cc(OC)ccc1Br)C2 to have a higher LogP value.,COc1ccc2c(c1)CCN(S(=O)(=O)CCNC(=O)c1cc(OC)ccc1Br)C2,2.584200000000001
+220718,Modify the molecule CCc1c(C(=O)NC[C@@H]2COc3ccccc3O2)c(=O)cc(C)n1CC[NH+]1CCCCC1 to increase its LogP value.,CCc1c(C(=O)NC[C@@H]2COc3ccccc3O2)c(=O)cc(C)n1CC[NH+]1CCCCC1,1.357720000000001
+193122,Modify the molecule CCC1(CNC(=O)C(=O)Nc2cc(C)c(Cl)cc2OC)CC1 to increase its LogP value.,CCC1(CNC(=O)C(=O)Nc2cc(C)c(Cl)cc2OC)CC1,2.9019200000000014
+14443,Please modify the molecule [NH3+]C[C@H]1CC[C@@H](C(=O)N2CCCCCC2)O1 to increase its LogP value.,[NH3+]C[C@H]1CC[C@@H](C(=O)N2CCCCCC2)O1,0.17849999999999921
+42391,Please optimize the molecule COC(=O)[C@@H]1CCCCC[C@@H]1NC(=O)c1cnc2c(C)cccn2c1=O to have a higher LogP value.,COC(=O)[C@@H]1CCCCC[C@@H]1NC(=O)c1cnc2c(C)cccn2c1=O,1.85462
+239057,Modify the molecule C[C@@H](Sc1n[nH]c(N)n1)C(=O)Nc1ccc2ccccc2c1 to decrease its LogP value.,C[C@@H](Sc1n[nH]c(N)n1)C(=O)Nc1ccc2ccccc2c1,2.6594000000000007
+214025,Modify the molecule Cc1noc2nc(C(C)C)cc(C(=O)N(C)C(C)C)c12 to increase its LogP value.,Cc1noc2nc(C(C)C)cc(C(=O)N(C)C(C)C)c12,3.1350200000000017
+144603,Modify the molecule CC[C@H](C(=O)Nc1c(C)noc1C)n1ccc(C(=O)Nc2c(C)noc2C)n1 to decrease its LogP value.,CC[C@H](C(=O)Nc1c(C)noc1C)n1ccc(C(=O)Nc2c(C)noc2C)n1,2.9348800000000006
+214199,Optimize the molecule C[C@H]1CC(C(=O)OC2CCN(CC(F)(F)F)CC2)C[C@H](C)O1 to have a lower LogP value.,C[C@H]1CC(C(=O)OC2CCN(CC(F)(F)F)CC2)C[C@H](C)O1,2.759900000000001
+128405,Optimize the molecule CCO[C@@H]1CCC[NH+](Cc2ncc(-c3ccc(F)cc3)o2)C1 to have a lower LogP value.,CCO[C@@H]1CCC[NH+](Cc2ncc(-c3ccc(F)cc3)o2)C1,2.0645
+101575,Optimize the molecule C[C@H]([NH2+][C@@H]1CCCN(c2cccnn2)C1)c1ccc2c(c1)OCCCO2 to have a higher LogP value.,C[C@H]([NH2+][C@@H]1CCCN(c2cccnn2)C1)c1ccc2c(c1)OCCCO2,1.9312999999999998
+105470,Please optimize the molecule CCn1c(C)cn2c3c(=O)n(Cc4c(Cl)cccc4Cl)c(=O)n(C)c3nc12 to have a higher LogP value.,CCn1c(C)cn2c3c(=O)n(Cc4c(Cl)cccc4Cl)c(=O)n(C)c3nc12,2.832820000000001
+212284,Please modify the molecule Cc1ccc(C2=NO[C@@H](Cn3nnc4ccccc43)C2)cc1 to decrease its LogP value.,Cc1ccc(C2=NO[C@@H](Cn3nnc4ccccc43)C2)cc1,2.932920000000001
+135862,Please optimize the molecule CC(C)(C)OC(=O)[C@H]1CC[C@]1([NH3+])C(=O)[O-] to have a lower LogP value.,CC(C)(C)OC(=O)[C@H]1CC[C@]1([NH3+])C(=O)[O-],-1.5312999999999972
+64745,Modify the molecule C[C@H]1C(=O)N2CCC[C@@H]2C(=O)N1C1CCC(C)(C)CC1 to have a lower LogP value.,C[C@H]1C(=O)N2CCC[C@@H]2C(=O)N1C1CCC(C)(C)CC1,2.1769
+151719,Modify the molecule Cc1ccc(Cl)cc1NC(=O)C(=O)N1CCO[C@@H](C)C1 to increase its LogP value.,Cc1ccc(Cl)cc1NC(=O)C(=O)N1CCO[C@@H](C)C1,1.8342199999999995
+50523,Please modify the molecule COCCCNC(=O)c1ccc(-n2ccnn2)cc1 to decrease its LogP value.,COCCCNC(=O)c1ccc(-n2ccnn2)cc1,1.0335999999999994
+43846,Optimize the molecule Cn1nnnc1SCC[NH2+]C1CCN(c2ncnc3[nH]cnc23)CC1 to have a higher LogP value.,Cn1nnnc1SCC[NH2+]C1CCN(c2ncnc3[nH]cnc23)CC1,-0.7990999999999986
+210645,Modify the molecule O=C(NCc1ccccc1COCc1ccccc1)c1cc2ccoc2cn1 to have a lower LogP value.,O=C(NCc1ccccc1COCc1ccccc1)c1cc2ccoc2cn1,4.474600000000004
+68213,Please optimize the molecule N#CC1=C(N)Oc2cc(OC(=O)c3ccc(F)cc3)ccc2[C@@H]1c1cccc(F)c1 to have a higher LogP value.,N#CC1=C(N)Oc2cc(OC(=O)c3ccc(F)cc3)ccc2[C@@H]1c1cccc(F)c1,4.402180000000002
+132297,Modify the molecule CCC1(CC)CC[NH+](CC[NH2+]C[C@@H]2CCOC2)C1 to have a lower LogP value.,CCC1(CC)CC[NH+](CC[NH2+]C[C@@H]2CCOC2)C1,-0.318699999999996
+221301,Modify the molecule CCN1CCC[C@H]1C[NH+](Cc1ccncc1)Cc1cccc2ccccc12 to have a higher LogP value.,CCN1CCC[C@H]1C[NH+](Cc1ccncc1)Cc1cccc2ccccc12,3.3042000000000025
+199463,Modify the molecule C[C@H]1C[C@@H](N[C@@H]2CC(=O)N(CC(F)(F)F)C2)CC[NH+]1Cc1ccccc1 to have a higher LogP value.,C[C@H]1C[C@@H](N[C@@H]2CC(=O)N(CC(F)(F)F)C2)CC[NH+]1Cc1ccccc1,1.3752000000000004
+146700,Please optimize the molecule COc1cccc(OC[C@H]2CCCN(C(=O)c3ncoc3C3CC3)C2)c1 to have a lower LogP value.,COc1cccc(OC[C@H]2CCCN(C(=O)c3ncoc3C3CC3)C2)c1,3.4918000000000022
+54151,Modify the molecule COc1c(C[NH2+]CCCn2cnc3ccccc32)c(C)nn1C to have a lower LogP value.,COc1c(C[NH2+]CCCn2cnc3ccccc32)c(C)nn1C,1.2405199999999992
+22216,Please optimize the molecule C[C@H]1C[C@@H]1NC(=O)C(=O)Nc1cccc(Oc2ccc(C#N)cc2)c1 to have a higher LogP value.,C[C@H]1C[C@@H]1NC(=O)C(=O)Nc1cccc(Oc2ccc(C#N)cc2)c1,2.8136800000000006
+93110,Please modify the molecule N#CCC(=O)NNC(=O)c1ccccc1C(=O)[O-] to decrease its LogP value.,N#CCC(=O)NNC(=O)c1ccccc1C(=O)[O-],-1.27522
+43339,Please optimize the molecule CC(C)C[C@H](C)N(C)C(=O)COc1cccc(F)c1 to have a lower LogP value.,CC(C)C[C@H](C)N(C)C(=O)COc1cccc(F)c1,3.097500000000002
+183810,Modify the molecule Cc1ccc(C[n+]2ccccc2NC(=O)c2ccnc(NC3CC3)c2)cc1 to decrease its LogP value.,Cc1ccc(C[n+]2ccccc2NC(=O)c2ccnc(NC3CC3)c2)cc1,3.5524200000000015
+232840,Optimize the molecule Cn1cnnc1CNC(=O)NNC(=O)c1cccs1 to have a higher LogP value.,Cn1cnnc1CNC(=O)NNC(=O)c1cccs1,0.020799999999999763
+100133,Modify the molecule COc1cc2c(cc1OC)CN(C(=O)CCC(=O)c1ccc3c(c1)CCC3)CC2 to have a lower LogP value.,COc1cc2c(cc1OC)CN(C(=O)CCC(=O)c1ccc3c(c1)CCC3)CC2,3.740300000000003
+69138,Optimize the molecule COC(=O)c1c([O-])n(O)c2ccc(OC)cc2[n+]1=O to have a lower LogP value.,COC(=O)c1c([O-])n(O)c2ccc(OC)cc2[n+]1=O,-0.33810000000000007
+48904,Modify the molecule CC(C)(C)C(=O)NC[C@H]1CCCN(c2ncccc2Cl)C1 to increase its LogP value.,CC(C)(C)C(=O)NC[C@H]1CCCN(c2ncccc2Cl)C1,3.1137000000000015
+136071,Please modify the molecule COC(=O)[C@@H]1CCCC[C@H]1NC(=O)c1ncccc1C(F)(F)F to increase its LogP value.,COC(=O)[C@@H]1CCCC[C@H]1NC(=O)c1ncccc1C(F)(F)F,2.5620000000000003
+184106,Modify the molecule O=C(NNc1ccccc1Cl)N[C@@H]1CCC[C@@H](C(F)(F)F)C1 to have a lower LogP value.,O=C(NNc1ccccc1Cl)N[C@@H]1CCC[C@@H](C(F)(F)F)C1,4.087200000000003
+109806,Modify the molecule COc1ccccc1C[NH+]1CCC([C@H](NC(=O)c2ccccn2)c2nccs2)CC1 to decrease its LogP value.,COc1ccccc1C[NH+]1CCC([C@H](NC(=O)c2ccccn2)c2nccs2)CC1,2.5129
+190349,Modify the molecule O=C(CCc1ccc2c(c1)OCCCO2)O[C@H]1CCOC1 to have a lower LogP value.,O=C(CCc1ccc2c(c1)OCCCO2)O[C@H]1CCOC1,2.1125999999999996
+69055,Please optimize the molecule O=C([C@@H](c1ccccc1)N1CC[NH+]([C@@H]2CCS(=O)(=O)C2)CC1)N1CCCC1 to have a higher LogP value.,O=C([C@@H](c1ccccc1)N1CC[NH+]([C@@H]2CCS(=O)(=O)C2)CC1)N1CCCC1,-0.26229999999999687
+106245,Modify the molecule CC1=C[C@H](NC(=O)CS[C@@H]2Nc3ccccc3C(=O)N2NS(=O)(=O)c2ccc(C)cc2)N=N1 to have a higher LogP value.,CC1=C[C@H](NC(=O)CS[C@@H]2Nc3ccccc3C(=O)N2NS(=O)(=O)c2ccc(C)cc2)N=N1,2.5849200000000003
+201553,Please modify the molecule C[C@@H]([C@@H](C)O)[NH+](C)[C@@H]1CCC[C@@H]1C[NH3+] to decrease its LogP value.,C[C@@H]([C@@H](C)O)[NH+](C)[C@@H]1CCC[C@@H]1C[NH3+],-1.3189999999999966
+197163,Please modify the molecule O=C1c2ccccc2N[C@@H](c2ccc(OCc3cn4ccccc4n3)cc2)N1C[C@H]1CCCO1 to decrease its LogP value.,O=C1c2ccccc2N[C@@H](c2ccc(OCc3cn4ccccc4n3)cc2)N1C[C@H]1CCCO1,4.658800000000003
+109655,Optimize the molecule Cc1nn(-c2ccccc2)c(Oc2ccc(F)cc2)c1C[NH2+]C[C@H]1CCCO1 to have a lower LogP value.,Cc1nn(-c2ccccc2)c(Oc2ccc(F)cc2)c1C[NH2+]C[C@H]1CCCO1,3.3545200000000017
+161712,Optimize the molecule CC(C)(C)C1CCC(=CC(=O)NC[C@@H]2CCCN(c3ncccn3)C2)CC1 to have a higher LogP value.,CC(C)(C)C1CCC(=CC(=O)NC[C@@H]2CCCN(c3ncccn3)C2)CC1,3.9719000000000033
+51244,Optimize the molecule CCc1onc(C)c1NC(=O)C[C@H](C)SC to have a lower LogP value.,CCc1onc(C)c1NC(=O)C[C@H](C)SC,2.6255200000000007
+99489,Optimize the molecule Cc1ccc(N2C[C@H](C(=O)N3CCN(c4nccn4-c4cccc(Cl)c4)CC3)CC2=O)cc1C to have a higher LogP value.,Cc1ccc(N2C[C@H](C(=O)N3CCN(c4nccn4-c4cccc(Cl)c4)CC3)CC2=O)cc1C,3.8442400000000028
+17996,Modify the molecule CC(C)Oc1ccc(NC(=O)N2CC[C@@H](C)C[C@@H]2C)cc1C#N to have a higher LogP value.,CC(C)Oc1ccc(NC(=O)N2CC[C@@H](C)C[C@@H]2C)cc1C#N,3.997780000000003
+141762,Please optimize the molecule Cc1ccc(-c2ncco2)cc1NC(=O)N1CCOC(C)(C)C1 to have a higher LogP value.,Cc1ccc(-c2ncco2)cc1NC(=O)N1CCOC(C)(C)C1,3.292720000000002
+171710,Modify the molecule COc1ccc(OCCN(C)C(=O)C(=O)Nc2ccc(C)cc2)cc1 to increase its LogP value.,COc1ccc(OCCN(C)C(=O)C(=O)Nc2ccc(C)cc2)cc1,2.479520000000001
+159272,Please modify the molecule Cc1nc2ccccc2n1CCNC(=O)CCNC(=O)c1cccs1 to increase its LogP value.,Cc1nc2ccccc2n1CCNC(=O)CCNC(=O)c1cccs1,2.3425200000000004
+59408,Optimize the molecule Cc1cc([C@]2(C)NC(=O)N(Cc3cccc4cccnc34)C2=O)c(C)o1 to have a higher LogP value.,Cc1cc([C@]2(C)NC(=O)N(Cc3cccc4cccnc34)C2=O)c(C)o1,3.4118400000000024
+153819,Please modify the molecule CNC(=O)[C@@H](C)CN(C)C(=O)Nc1ccc(CCN2CCOCC2)cc1 to increase its LogP value.,CNC(=O)[C@@H](C)CN(C)C(=O)Nc1ccc(CCN2CCOCC2)cc1,1.4071000000000005
+93261,Please modify the molecule C[C@H](O/N=C(/N)c1cccs1)C(=O)N1CCN(c2ccccc2)CC1 to decrease its LogP value.,C[C@H](O/N=C(/N)c1cccs1)C(=O)N1CCN(c2ccccc2)CC1,2.1223
+89005,Please modify the molecule Cc1cccc(CN[C@H](C)c2nc(C)cs2)n1 to decrease its LogP value.,Cc1cccc(CN[C@H](C)c2nc(C)cs2)n1,3.005740000000001
+112658,Modify the molecule CC(=O)Nc1ccc(C)c(NC(=O)N2CCCSCC2)c1 to have a higher LogP value.,CC(=O)Nc1ccc(C)c(NC(=O)N2CCCSCC2)c1,2.924220000000001
+61767,Modify the molecule COC(=O)c1ccc(NC(=O)[C@@H](C)n2nc(-c3ccc(C)cc3)ccc2=O)cc1 to decrease its LogP value.,COC(=O)c1ccc(NC(=O)[C@@H](C)n2nc(-c3ccc(C)cc3)ccc2=O)cc1,3.205020000000002
+77445,Please modify the molecule Cc1n[nH]c2ncc(NC(=O)NCCCC[NH+]3CCCC[C@H]3C)cc12 to increase its LogP value.,Cc1n[nH]c2ncc(NC(=O)NCCCC[NH+]3CCCC[C@H]3C)cc12,1.6253199999999997
+40354,Optimize the molecule C=CCNC(=S)Nc1sc2c(c1C(N)=O)CCCC2 to have a higher LogP value.,C=CCNC(=S)Nc1sc2c(c1C(N)=O)CCCC2,2.1982
+77546,Please modify the molecule COc1ccc(N[C@@H](C)C(=O)N[C@H]2CCOc3ccccc32)cn1 to increase its LogP value.,COc1ccc(N[C@@H](C)C(=O)N[C@H]2CCOc3ccccc32)cn1,2.5306000000000006
+27018,Please optimize the molecule Cc1nn(C)c(C)c1CNC[C@H](c1cccs1)[NH+]1CCCC1 to have a higher LogP value.,Cc1nn(C)c(C)c1CNC[C@H](c1cccs1)[NH+]1CCCC1,1.60804
+154485,Modify the molecule O=C([O-])c1cc(NS(=O)(=O)c2cccc(F)c2)ccc1N1CCSCC1 to decrease its LogP value.,O=C([O-])c1cc(NS(=O)(=O)c2cccc(F)c2)ccc1N1CCSCC1,1.5432
+24787,Modify the molecule O=C1c2ccccc2N[C@H](c2cccc(Br)c2)N1Cc1ccco1 to have a higher LogP value.,O=C1c2ccccc2N[C@H](c2cccc(Br)c2)N1Cc1ccco1,4.808800000000003
+46165,Modify the molecule COC1CC[NH+](CCNC(=O)[C@H]2CCCS2)CC1 to decrease its LogP value.,COC1CC[NH+](CCNC(=O)[C@H]2CCCS2)CC1,-0.30809999999999715
+195474,Please optimize the molecule C[NH+](C)C[C@@H](O)CNC(=O)c1ccccc1Br to have a lower LogP value.,C[NH+](C)C[C@@H](O)CNC(=O)c1ccccc1Br,-0.3156999999999994
+197054,Please modify the molecule CC(C)(C)CC(C)(C)[NH2+]Cc1ncn(-c2ccccc2)n1 to increase its LogP value.,CC(C)(C)CC(C)(C)[NH2+]Cc1ncn(-c2ccccc2)n1,2.5455000000000005
+126353,Please modify the molecule CC(C)(C)c1nc(CNc2ccc(OC(F)F)cn2)no1 to increase its LogP value.,CC(C)(C)c1nc(CNc2ccc(OC(F)F)cn2)no1,2.975600000000001
+167479,Please modify the molecule CC(C)n1cc(C(=O)NCC2CCCCC2)c(=O)c(C(=O)N2C[C@H](C)O[C@H](C)C2)c1 to decrease its LogP value.,CC(C)n1cc(C(=O)NCC2CCCCC2)c(=O)c(C(=O)N2C[C@H](C)O[C@H](C)C2)c1,2.9887000000000015
+220206,Modify the molecule CC1CCC(NC(=O)[C@H]2CCCN(S(=O)(=O)c3c[nH]c(C(=O)N4CCCC4)c3)C2)CC1 to have a higher LogP value.,CC1CCC(NC(=O)[C@H]2CCCN(S(=O)(=O)c3c[nH]c(C(=O)N4CCCC4)c3)C2)CC1,2.3462999999999994
+141243,Please modify the molecule CCc1nn(C)c(OC)c1CNC(=O)NC[C@@H]1CCO[C@@H]1C(C)C to increase its LogP value.,CCc1nn(C)c(OC)c1CNC(=O)NC[C@@H]1CCO[C@@H]1C(C)C,1.8514
+194006,Optimize the molecule COc1ncnc(NCc2c(C)noc2C)c1[N+](=O)[O-] to have a lower LogP value.,COc1ncnc(NCc2c(C)noc2C)c1[N+](=O)[O-],1.6103399999999999
+201393,Optimize the molecule COC(=O)[C@H](C)Sc1nc2ccc(Br)cc2c(=O)n1CC(C)C to have a lower LogP value.,COC(=O)[C@H](C)Sc1nc2ccc(Br)cc2c(=O)n1CC(C)C,3.468600000000002
+50691,Please optimize the molecule CC[C@@H]1S/C(=N\c2cccc(Cl)c2)NC1=O to have a higher LogP value.,CC[C@@H]1S/C(=N\c2cccc(Cl)c2)NC1=O,2.969100000000001
+95893,Please modify the molecule CC(=O)c1ccc(OCCSCC(C)C)cc1 to increase its LogP value.,CC(=O)c1ccc(OCCSCC(C)C)cc1,3.6572000000000022
+44766,Optimize the molecule COCC1CC[NH+]([C@@H]2CCC[C@@]([NH3+])(C(=O)[O-])C2)CC1 to have a higher LogP value.,COCC1CC[NH+]([C@@H]2CCC[C@@]([NH3+])(C(=O)[O-])C2)CC1,-2.3990999999999945
+167835,Modify the molecule CCc1cnc(C)nc1N(C)Cc1cnn(C)c1C to decrease its LogP value.,CCc1cnc(C)nc1N(C)Cc1cnn(C)c1C,2.02574
+114681,Please modify the molecule CCC(=O)N1CCC[C@H](C(=O)Oc2cccc(C(=O)N(C)C)c2)C1 to decrease its LogP value.,CCC(=O)N1CCC[C@H](C(=O)Oc2cccc(C(=O)N(C)C)c2)C1,1.9424000000000001
+117099,Modify the molecule CC(C)[C@H](C)NC(=O)c1cccc(SCC#N)c1 to have a higher LogP value.,CC(C)[C@H](C)NC(=O)c1cccc(SCC#N)c1,3.0765800000000016
+207050,Optimize the molecule C[C@@H](CNC(=O)N1CCC(OC[C@H]2CCCO2)CC1)C[NH+]1CCCCC1 to have a higher LogP value.,C[C@@H](CNC(=O)N1CCC(OC[C@H]2CCCO2)CC1)C[NH+]1CCCCC1,1.060900000000002
+97465,Modify the molecule CC[C@@H](Nc1ccc2nnc(C)n2n1)c1nc(C(F)(F)F)cs1 to decrease its LogP value.,CC[C@@H](Nc1ccc2nnc(C)n2n1)c1nc(C(F)(F)F)cs1,3.4712200000000015
+204469,Please modify the molecule CC(C)[NH2+]C[C@@H](C)C(=O)OC(C)(C)C to increase its LogP value.,CC(C)[NH2+]C[C@@H](C)C(=O)OC(C)(C)C,0.9359999999999997
+214116,Optimize the molecule CCn1c(S[C@@H](C)c2nc3ccccc3c(=O)[nH]2)nc2cc(S(=O)(=O)N3CCOCC3)ccc21 to have a higher LogP value.,CCn1c(S[C@@H](C)c2nc3ccccc3c(=O)[nH]2)nc2cc(S(=O)(=O)N3CCOCC3)ccc21,3.166900000000002
+119839,Please optimize the molecule Cc1nn(C)cc1[C@H](C)NC(=O)N1CCC(OCC(C)C)CC1 to have a lower LogP value.,Cc1nn(C)cc1[C@H](C)NC(=O)N1CCC(OCC(C)C)CC1,2.636120000000001
+78999,Optimize the molecule C[C@H]1CC([NH+]2CCN([C@@H](C)C(F)(F)F)CC2)C[C@@H](C)O1 to have a higher LogP value.,C[C@H]1CC([NH+]2CCN([C@@H](C)C(F)(F)F)CC2)C[C@@H](C)O1,1.0937000000000001
+172964,Optimize the molecule NC(=O)C[C@@H](NC(=O)c1cccc(C(=O)N2CCCC2)n1)C1CCCCC1 to have a lower LogP value.,NC(=O)C[C@@H](NC(=O)c1cccc(C(=O)N2CCCC2)n1)C1CCCCC1,1.8716999999999986
+156126,Please modify the molecule CSc1nc(N2CCOCC2)c2cnn(CCNC(=O)Cc3cccc(C)c3)c2n1 to increase its LogP value.,CSc1nc(N2CCOCC2)c2cnn(CCNC(=O)Cc3cccc(C)c3)c2n1,2.0521199999999995
+246966,Modify the molecule CN1CC[C@H](CNC(=O)Cn2ccc(=O)[nH]c2=O)c2ccccc21 to increase its LogP value.,CN1CC[C@H](CNC(=O)Cn2ccc(=O)[nH]c2=O)c2ccccc21,0.27650000000000047
+242542,Optimize the molecule C[C@H](CO)[NH2+]CCCOc1cccnc1 to have a higher LogP value.,C[C@H](CO)[NH2+]CCCOc1cccnc1,-0.20530000000000026
+28405,Modify the molecule COC(=O)c1cc(-c2ccc(/C=C3\C(=O)N(c4ccccc4)N=C3C)o2)ccc1Cl to have a higher LogP value.,COC(=O)c1cc(-c2ccc(/C=C3\C(=O)N(c4ccccc4)N=C3C)o2)ccc1Cl,5.192700000000004
+50974,Please optimize the molecule CC[C@@H](C)[C@@H](C[NH3+])N1CCc2ccccc2C1 to have a lower LogP value.,CC[C@@H](C)[C@@H](C[NH3+])N1CCc2ccccc2C1,1.7013
+76409,Please modify the molecule Cn1ncnc1CNC(=O)N(CC[NH+](C)C)Cc1ccc(F)cc1F to increase its LogP value.,Cn1ncnc1CNC(=O)N(CC[NH+](C)C)Cc1ccc(F)cc1F,-0.05039999999999778
+164832,Optimize the molecule COc1ccc(N2CCN(C(=O)c3ccccc3NC(=O)C3=C(C)OCCS3)CC2)cc1 to have a higher LogP value.,COc1ccc(N2CCN(C(=O)c3ccccc3NC(=O)C3=C(C)OCCS3)CC2)cc1,3.591000000000002
+125708,Modify the molecule Cc1cnc(CN2CC3(CCC2=O)CC[NH+](CCc2nccn2C)CC3)cn1 to have a lower LogP value.,Cc1cnc(CN2CC3(CCC2=O)CC[NH+](CCc2nccn2C)CC3)cn1,0.5487200000000023
+223994,Please optimize the molecule CC1(C)C[C@@H]2C[C@@](C)(CN2C(=O)CSc2cccc[n+]2[O-])C1 to have a lower LogP value.,CC1(C)C[C@@H]2C[C@@](C)(CN2C(=O)CSc2cccc[n+]2[O-])C1,2.8393000000000015
+242209,Modify the molecule C[C@@H](Cc1ccc(C(F)(F)F)cc1)NC(=O)[C@@H]1CSC(=O)N1 to increase its LogP value.,C[C@@H](Cc1ccc(C(F)(F)F)cc1)NC(=O)[C@@H]1CSC(=O)N1,2.5776000000000003
+4915,Modify the molecule O=C(Nc1ccccc1C(=O)NCc1ccccc1)c1cnc2ccccc2n1 to have a lower LogP value.,O=C(Nc1ccccc1C(=O)NCc1ccccc1)c1cnc2ccccc2n1,3.812100000000002
+169655,Please optimize the molecule C[C@]1(CNC(=O)N2CCC(OCc3ccccc3F)CC2)CCCS1 to have a lower LogP value.,C[C@]1(CNC(=O)N2CCC(OCc3ccccc3F)CC2)CCCS1,3.802000000000003
+48611,Please modify the molecule CCC[C@@H]1CCC(=O)[C@H](C(C)C)C1 to decrease its LogP value.,CCC[C@@H]1CCC(=O)[C@H](C(C)C)C1,3.427900000000002
+159363,Modify the molecule Cc1ccc(NC(=O)Cc2ccc(S(=O)(=O)N3CCCCC3)cc2)cc1C to have a higher LogP value.,Cc1ccc(NC(=O)Cc2ccc(S(=O)(=O)N3CCCCC3)cc2)cc1C,3.6592400000000023
+143556,Modify the molecule CSC[C@H]1CCN(C(=O)Nc2ccc(Br)nc2C)C1 to decrease its LogP value.,CSC[C@H]1CCN(C(=O)Nc2ccc(Br)nc2C)C1,3.369320000000002
+187677,Please optimize the molecule CC(C)(C)C(=O)N1CCC(C(=O)OCCCc2ccccc2)CC1 to have a lower LogP value.,CC(C)(C)C(=O)N1CCC(C(=O)OCCCc2ccccc2)CC1,3.4471000000000025
+173163,Modify the molecule CCCC(CCC)CC(=O)N1CCC[C@H]1c1c(C)n[nH]c1C to increase its LogP value.,CCCC(CCC)CC(=O)N1CCC[C@H]1c1c(C)n[nH]c1C,4.296540000000004
+58506,Please optimize the molecule C/[NH+]=C(/NCCC(=O)Nc1ccc(C)cn1)N1CCC[C@@H](C)C1 to have a higher LogP value.,C/[NH+]=C(/NCCC(=O)Nc1ccc(C)cn1)N1CCC[C@@H](C)C1,0.10652000000000106
+35627,Modify the molecule O=[N+]([O-])c1ccc(-n2nnnc2SCc2cccc(Cl)c2)cc1 to decrease its LogP value.,O=[N+]([O-])c1ccc(-n2nnnc2SCc2cccc(Cl)c2)cc1,3.516200000000002
+57528,Please modify the molecule CCc1c(C)nc(SCC(=O)Nc2nc(-c3ccc(OC)cc3)cs2)[nH]c1=O to increase its LogP value.,CCc1c(C)nc(SCC(=O)Nc2nc(-c3ccc(OC)cc3)cs2)[nH]c1=O,3.5036200000000015
+28769,Please optimize the molecule CCc1cc2c(Nc3cnn(CC(=O)N(C)C)c3)ncnc2s1 to have a lower LogP value.,CCc1cc2c(Nc3cnn(CC(=O)N(C)C)c3)ncnc2s1,2.282
+228088,Modify the molecule CC(C)(C)C(=O)CSc1nnc(-c2ccc3c(c2)OCO3)n1-c1ccccc1 to decrease its LogP value.,CC(C)(C)C(=O)CSc1nnc(-c2ccc3c(c2)OCO3)n1-c1ccccc1,4.370300000000004
+166022,Optimize the molecule Cc1ccc(Br)cc1S(=O)(=O)N1CCC[C@H](N2CCCC2=O)C1 to have a higher LogP value.,Cc1ccc(Br)cc1S(=O)(=O)N1CCC[C@H](N2CCCC2=O)C1,2.5330200000000005
+4593,Please optimize the molecule COc1ccc(/C=C2\SC(=O)N(CC(=O)NCC(=O)[O-])C2=O)cc1OC to have a lower LogP value.,COc1ccc(/C=C2\SC(=O)N(CC(=O)NCC(=O)[O-])C2=O)cc1OC,-0.3937999999999997
+225543,Modify the molecule COc1cc(NC(=O)C[NH+]2CCCN(c3ncccn3)CC2)ccc1Cl to have a lower LogP value.,COc1cc(NC(=O)C[NH+]2CCCN(c3ncccn3)CC2)ccc1Cl,0.8723000000000001
+225382,Modify the molecule CN(CC(=O)N1CCC(OCc2cccnc2)CC1)c1ccccc1 to increase its LogP value.,CN(CC(=O)N1CCC(OCc2cccnc2)CC1)c1ccccc1,2.7256
+18138,Optimize the molecule Brc1c[nH]c(-c2nc(-c3cccs3)no2)c1 to have a lower LogP value.,Brc1c[nH]c(-c2nc(-c3cccs3)no2)c1,3.5557000000000007
+122531,Optimize the molecule C[C@H]1C[C@@H](C)CN(C(=O)[C@@H](C)S(=O)(=O)c2nccn2C)C1 to have a lower LogP value.,C[C@H]1C[C@@H](C)CN(C(=O)[C@@H](C)S(=O)(=O)c2nccn2C)C1,1.0867999999999998
+78340,Modify the molecule C#CCN[C@H]1CCCC[C@H]1[C@@H]1CCCC[NH2+]1 to increase its LogP value.,C#CCN[C@H]1CCCC[C@H]1[C@@H]1CCCC[NH2+]1,0.8838999999999999
+222825,Please optimize the molecule O=C(Cc1ccc([N+](=O)[O-])cc1)NC[C@H](c1cccs1)N1CCOCC1 to have a higher LogP value.,O=C(Cc1ccc([N+](=O)[O-])cc1)NC[C@H](c1cccs1)N1CCOCC1,2.3885000000000005
+242709,Modify the molecule COC(=O)c1c(C)sc(-c2c(-c3ccc(OC)c(OC)c3)[nH]c3c2c(=O)n(C)c(=O)n3C)c1[O-] to increase its LogP value.,COC(=O)c1c(C)sc(-c2c(-c3ccc(OC)c(OC)c3)[nH]c3c2c(=O)n(C)c(=O)n3C)c1[O-],2.1466199999999986
+103644,Optimize the molecule CN1C(=O)NC(=O)/C(=C2\C[C@H](c3cccs3)NN2)C1=O to have a higher LogP value.,CN1C(=O)NC(=O)/C(=C2\C[C@H](c3cccs3)NN2)C1=O,0.24939999999999973
+206181,Modify the molecule COc1ncccc1C(=O)N1Cc2nn(-c3ccc(C)c(C)c3)c(-n3cccc3)c2C1 to increase its LogP value.,COc1ncccc1C(=O)N1Cc2nn(-c3ccc(C)c(C)c3)c(-n3cccc3)c2C1,3.8394400000000033
+88722,Modify the molecule CSc1ccccc1C(=O)NNC(=O)c1nn(-c2ccccc2)c(=O)c2ccccc12 to increase its LogP value.,CSc1ccccc1C(=O)NNC(=O)c1nn(-c2ccccc2)c(=O)c2ccccc12,3.182400000000002
+65830,Modify the molecule CCOc1cc2c(cc1NC(=O)Cc1csc(-c3ccsc3)n1)O[C@H](C)C2 to decrease its LogP value.,CCOc1cc2c(cc1NC(=O)Cc1csc(-c3ccsc3)n1)O[C@H](C)C2,4.774900000000004
+5903,Please modify the molecule CO[C@@H](C[NH2+][C@H](C)C1CCOCC1)c1cccc(Cl)c1 to increase its LogP value.,CO[C@@H](C[NH2+][C@H](C)C1CCOCC1)c1cccc(Cl)c1,2.4060000000000006
+42081,Optimize the molecule Cc1cccc(C(=O)NC2CCN(C(=O)NC3CCCCC3)CC2)c1 to have a lower LogP value.,Cc1cccc(C(=O)NC2CCN(C(=O)NC3CCCCC3)CC2)c1,3.2315200000000024
+12873,Please optimize the molecule C[C@H]1CCCC[C@@H]1NC(=O)[C@@H](C)Sc1nc2ccccc2c(=O)n1Cc1ccco1 to have a higher LogP value.,C[C@H]1CCCC[C@@H]1NC(=O)[C@@H](C)Sc1nc2ccccc2c(=O)n1Cc1ccco1,4.213300000000003
+141911,Modify the molecule COc1ccc(-c2csc(NC(=O)CSc3ccc(NC(C)=O)cc3)n2)cc1 to decrease its LogP value.,COc1ccc(-c2csc(NC(=O)CSc3ccc(NC(C)=O)cc3)n2)cc1,4.507900000000003
+56346,Optimize the molecule CC(C)=CC(=O)N1CCC(n2nccc2NC(=O)c2ccc3c(c2)OCO3)CC1 to have a lower LogP value.,CC(C)=CC(=O)N1CCC(n2nccc2NC(=O)c2ccc3c(c2)OCO3)CC1,2.993800000000001
+230978,Please modify the molecule CSCc1c(C(=O)Nc2cc(C)nn2-c2ccccc2F)oc2ccccc12 to increase its LogP value.,CSCc1c(C(=O)Nc2cc(C)nn2-c2ccccc2F)oc2ccccc12,5.181320000000004
+49655,Modify the molecule COc1cccc(C(=O)N2CCN(C(=O)Cn3cnc4ccccc43)CC2)c1 to increase its LogP value.,COc1cccc(C(=O)N2CCN(C(=O)Cn3cnc4ccccc43)CC2)c1,2.029499999999999
+85916,Please modify the molecule CC(C)CCn1nnnc1[C@H](C(C)C)[NH+]1CCN(c2ccccc2)CC1 to increase its LogP value.,CC(C)CCn1nnnc1[C@H](C(C)C)[NH+]1CCN(c2ccccc2)CC1,1.821400000000001
+26276,Optimize the molecule COc1ccccc1NC(=O)CNc1cccc(C#Cc2ccccc2)c1 to have a lower LogP value.,COc1ccccc1NC(=O)CNc1cccc(C#Cc2ccccc2)c1,4.145600000000002
+107095,Please modify the molecule C[NH+]1CCN(Cc2ccc(F)cc2Cl)CC1 to decrease its LogP value.,C[NH+]1CCN(Cc2ccc(F)cc2Cl)CC1,0.8093999999999999
+84125,Please optimize the molecule CS[C@@H]1CC[C@@H](NC(=O)N2CCC(CC(=O)N3CC[NH+](C)CC3)CC2)C1 to have a lower LogP value.,CS[C@@H]1CC[C@@H](NC(=O)N2CCC(CC(=O)N3CC[NH+](C)CC3)CC2)C1,0.4391000000000027
+55988,Please optimize the molecule CC(=O)Nc1cccc(NC(=O)c2cc(Cl)c[nH]2)c1C to have a lower LogP value.,CC(=O)Nc1cccc(NC(=O)c2cc(Cl)c[nH]2)c1C,3.187220000000001
+231676,Modify the molecule CCCCS(=O)(=O)NCc1cn(C)nc1C to have a lower LogP value.,CCCCS(=O)(=O)NCc1cn(C)nc1C,0.9480200000000001
+188426,Optimize the molecule CC[C@@H]1CCc2c(sc(NC(=O)COCC(=O)[O-])c2C(N)=O)C1 to have a higher LogP value.,CC[C@@H]1CCc2c(sc(NC(=O)COCC(=O)[O-])c2C(N)=O)C1,0.06690000000000051
+140495,Please modify the molecule CN1C(=O)c2ccccc2[C@@H](C(=O)Nc2nnc(C3CCC3)s2)[C@H]1c1ccc2c(c1)OCO2 to increase its LogP value.,CN1C(=O)c2ccccc2[C@@H](C(=O)Nc2nnc(C3CCC3)s2)[C@H]1c1ccc2c(c1)OCO2,4.083500000000003
+89474,Modify the molecule O=C(c1cc(Cl)ccn1)N1CCN(c2ccc([N+](=O)[O-])cc2)CC1 to increase its LogP value.,O=C(c1cc(Cl)ccn1)N1CCN(c2ccc([N+](=O)[O-])cc2)CC1,2.605600000000001
+93700,Please modify the molecule CCc1nc2ccccc2n1C[C@@H](O)COc1ccc(F)cc1 to increase its LogP value.,CCc1nc2ccccc2n1C[C@@H](O)COc1ccc(F)cc1,3.1777000000000015
+90032,Modify the molecule Cc1cc(C)c2c(=O)cc(C(=O)N(Cc3ccc(Cl)cc3)[C@@H]3CCS(=O)(=O)C3)oc2c1 to increase its LogP value.,Cc1cc(C)c2c(=O)cc(C(=O)N(Cc3ccc(Cl)cc3)[C@@H]3CCS(=O)(=O)C3)oc2c1,3.8927400000000025
+160815,Please modify the molecule C#Cc1cc(F)c(NC(=O)N[C@H]2CCCC[C@H]2C(N)=O)c(F)c1 to decrease its LogP value.,C#Cc1cc(F)c(NC(=O)N[C@H]2CCCC[C@H]2C(N)=O)c(F)c1,2.1117
+18768,Please modify the molecule COC[C@@H](C)NS(=O)(=O)Cc1ccc([N+](=O)[O-])cc1 to decrease its LogP value.,COC[C@@H](C)NS(=O)(=O)Cc1ccc([N+](=O)[O-])cc1,1.0491
+111722,Optimize the molecule COc1ccc(OC[C@H](C)NS(C)(=O)=O)cc1 to have a higher LogP value.,COc1ccc(OC[C@H](C)NS(C)(=O)=O)cc1,1.0116999999999998
+215426,Please optimize the molecule C[C@@H]1OCC[C@H]1C(=O)N(C)Cc1nc2c(s1)CCCC2 to have a higher LogP value.,C[C@@H]1OCC[C@H]1C(=O)N(C)Cc1nc2c(s1)CCCC2,2.4053000000000004
+4689,Optimize the molecule COc1ccc(-c2nc(CN3CCNC(=O)C3)c(C)o2)c2ccccc12 to have a lower LogP value.,COc1ccc(-c2nc(CN3CCNC(=O)C3)c(C)o2)c2ccccc12,2.743620000000001
+132588,Modify the molecule COc1cccc(CC(=O)N2CCN(Cc3csc(C)n3)CC2)c1 to have a lower LogP value.,COc1cccc(CC(=O)N2CCN(Cc3csc(C)n3)CC2)c1,2.3470200000000006
+82981,Please modify the molecule C=CCS(=O)(=O)NCCCO to decrease its LogP value.,C=CCS(=O)(=O)NCCCO,-0.5258
+28437,Modify the molecule O=S1(=O)CC[C@@H](C2(O)[C@H]3CCC[C@H]32)C1 to decrease its LogP value.,O=S1(=O)CC[C@@H](C2(O)[C@H]3CCC[C@H]32)C1,0.5821000000000001
+19617,Please optimize the molecule NC(=O)[C@H](c1ccc(F)cc1)N1CCCc2c(NC(=O)c3ccc(F)cc3)cccc21 to have a lower LogP value.,NC(=O)[C@H](c1ccc(F)cc1)N1CCCc2c(NC(=O)c3ccc(F)cc3)cccc21,4.1963000000000035
+192894,Modify the molecule O=C(NC[C@H](c1ccc2c(c1)OCO2)N1CCOCC1)C(=O)Nc1ccccc1F to increase its LogP value.,O=C(NC[C@H](c1ccc2c(c1)OCO2)N1CCOCC1)C(=O)Nc1ccccc1F,1.6825999999999994
+68209,Modify the molecule CCCNC(=O)CNC(=O)N1CCC[C@@H](COCC)C1 to have a higher LogP value.,CCCNC(=O)CNC(=O)N1CCC[C@@H](COCC)C1,0.9706999999999997
+72203,Please optimize the molecule CCC(=O)Nc1ccc(Cl)c(NC(=O)N(C)Cc2cnn(C)c2)c1 to have a lower LogP value.,CCC(=O)Nc1ccc(Cl)c(NC(=O)N(C)Cc2cnn(C)c2)c1,3.0859000000000014
+41275,Please modify the molecule CCC[C@H]([NH2+]C1CCN(S(=O)(=O)c2cnn(C)c2)CC1)C1CCCCC1 to decrease its LogP value.,CCC[C@H]([NH2+]C1CCN(S(=O)(=O)c2cnn(C)c2)CC1)C1CCCCC1,1.8856
+110498,Please modify the molecule CN(Cc1ccccc1)C(=O)CSc1ncn[nH]1 to decrease its LogP value.,CN(Cc1ccccc1)C(=O)CSc1ncn[nH]1,1.5554
+162862,Modify the molecule Cc1ccn2cc(-c3ccc(NC(=O)[C@H]4C[C@H]4C)cc3)nc2c1 to decrease its LogP value.,Cc1ccn2cc(-c3ccc(NC(=O)[C@H]4C[C@H]4C)cc3)nc2c1,3.9042200000000022
+228787,Modify the molecule CC(C)Cn1ccnc(N[C@@H]2CC[C@@H]([NH+](C)C)C2)c1=O to decrease its LogP value.,CC(C)Cn1ccnc(N[C@@H]2CC[C@@H]([NH+](C)C)C2)c1=O,0.37680000000000113
+219591,Modify the molecule O=C(Nc1ccccc1)NC1CCN(c2ccc([N+](=O)[O-])cc2[N+](=O)[O-])CC1 to have a higher LogP value.,O=C(Nc1ccccc1)NC1CCN(c2ccc([N+](=O)[O-])cc2[N+](=O)[O-])CC1,3.2935000000000016
+59937,Please optimize the molecule Cc1ccc(NC(=O)c2n[nH]c3c2CCC3)cc1C(=O)N(C)C to have a lower LogP value.,Cc1ccc(NC(=O)c2n[nH]c3c2CCC3)cc1C(=O)N(C)C,2.16092
+217629,Optimize the molecule O=C(NCC[C@H](O)c1ccccc1)Nc1ccc2c(c1)OCO2 to have a higher LogP value.,O=C(NCC[C@H](O)c1ccccc1)Nc1ccc2c(c1)OCO2,2.6605000000000008
+61498,Modify the molecule Cc1ncc([C@@H](C)NCC2(c3ccccc3C)CC2)s1 to have a higher LogP value.,Cc1ncc([C@@H](C)NCC2(c3ccccc3C)CC2)s1,4.1423400000000035
+108340,Please optimize the molecule CCOc1ccc(-c2[nH]ncc2C(=O)NCc2ccccn2)cc1Cl to have a lower LogP value.,CCOc1ccc(-c2[nH]ncc2C(=O)NCc2ccccn2)cc1Cl,3.453800000000001
+209223,Please modify the molecule C[NH+](C)[C@H]1CCN(C(=O)C(=O)c2ccccc2)C[C@H]1CCC(=O)[O-] to decrease its LogP value.,C[NH+](C)[C@H]1CCN(C(=O)C(=O)c2ccccc2)C[C@H]1CCC(=O)[O-],-1.238999999999996
+32650,Please optimize the molecule C[C@H](Cc1nnc(NC(=O)CC(C)(C)C)s1)c1ccccc1 to have a lower LogP value.,C[C@H](Cc1nnc(NC(=O)CC(C)(C)C)s1)c1ccccc1,4.259000000000003
+217455,Modify the molecule O=C(Cc1c[nH]c2cc(Cl)ccc12)NC[C@H]1CN2CCCC[C@@H]2CO1 to increase its LogP value.,O=C(Cc1c[nH]c2cc(Cl)ccc12)NC[C@H]1CN2CCCC[C@@H]2CO1,2.7333000000000007
+213943,Optimize the molecule Cc1ccc(N2C(=O)[C@@H]3[C@@H](N=NN3CC(=O)NCc3ccccc3Cl)C2=O)cc1C to have a higher LogP value.,Cc1ccc(N2C(=O)[C@@H]3[C@@H](N=NN3CC(=O)NCc3ccccc3Cl)C2=O)cc1C,2.56644
+210609,Please modify the molecule CN(CC(C)(C)C)C(=O)c1cccc(C(=O)N[C@@H](CO)c2ccco2)c1 to decrease its LogP value.,CN(CC(C)(C)C)C(=O)c1cccc(C(=O)N[C@@H](CO)c2ccco2)c1,2.8611000000000013
+57514,Please modify the molecule O=C(NC[C@H]1CC[NH+](C2CC2)C1)c1c[nH]c2nccc(Cl)c12 to increase its LogP value.,O=C(NC[C@H]1CC[NH+](C2CC2)C1)c1c[nH]c2nccc(Cl)c12,1.0133000000000003
+121857,Please modify the molecule Nc1cc[nH+]cc1[C@@H](O)c1cncc(Br)c1 to decrease its LogP value.,Nc1cc[nH+]cc1[C@@H](O)c1cncc(Br)c1,1.3221
+145006,Please optimize the molecule CCOc1ccc(CN2C(=O)c3ccccc3[C@H]2C(=O)NC[C@H]2CCCO2)cc1 to have a lower LogP value.,CCOc1ccc(CN2C(=O)c3ccccc3[C@H]2C(=O)NC[C@H]2CCCO2)cc1,3.0776000000000012
+152038,Optimize the molecule Cc1[nH]c2ccccc2c1/C=C(/C#N)C(=O)NC1CCCC1 to have a lower LogP value.,Cc1[nH]c2ccccc2c1/C=C(/C#N)C(=O)NC1CCCC1,3.4421000000000017
+113296,Please modify the molecule Cc1nc(C(=O)OC[C@@H]2CC(=O)N(C)[C@H]2c2cccc(Cl)c2)cs1 to increase its LogP value.,Cc1nc(C(=O)OC[C@@H]2CC(=O)N(C)[C@H]2c2cccc(Cl)c2)cs1,3.481320000000003
+125328,Modify the molecule CCCCOc1ccc(CN2C(=O)C3(OCCCO3)c3c(C)ccc(C)c32)cc1OC to have a lower LogP value.,CCCCOc1ccc(CN2C(=O)C3(OCCCO3)c3c(C)ccc(C)c32)cc1OC,4.627440000000004
+119613,Please modify the molecule C[C@H]1CCC[C@]2(CC1)C[NH+]=C(N)N2c1ccccc1F to decrease its LogP value.,C[C@H]1CCC[C@]2(CC1)C[NH+]=C(N)N2c1ccccc1F,1.3800000000000006
+47369,Modify the molecule CC[C@@H]([NH3+])[C@H](c1ccccc1F)N1CCC(C)(C)C1 to have a higher LogP value.,CC[C@@H]([NH3+])[C@H](c1ccccc1F)N1CCC(C)(C)C1,2.6192
+148525,Please optimize the molecule C=C(C)[C@@H](O)c1ccc2c(c1)OCO2 to have a higher LogP value.,C=C(C)[C@@H](O)c1ccc2c(c1)OCO2,2.0248
+190964,Modify the molecule CCCn1nccc1C(=O)NC[C@@H](O)c1ccc(C(C)C)cc1 to have a higher LogP value.,CCCn1nccc1C(=O)NC[C@@H](O)c1ccc(C(C)C)cc1,2.879900000000001
+194917,Modify the molecule COc1ccc2c(CC(=O)Oc3ccccc3C(F)(F)F)coc2c1 to have a higher LogP value.,COc1ccc2c(CC(=O)Oc3ccccc3C(F)(F)F)coc2c1,4.6083000000000025
+118079,Please optimize the molecule COc1ncnc(NC[C@@H]2CCCC[C@@H]2C)c1[N+](=O)[O-] to have a higher LogP value.,COc1ncnc(NC[C@@H]2CCCC[C@@H]2C)c1[N+](=O)[O-],2.6316000000000006
+138582,Please modify the molecule CC(=O)Oc1cc2c(C(=O)NCc3ccccc3)c(C)oc2c2ccccc12 to decrease its LogP value.,CC(=O)Oc1cc2c(C(=O)NCc3ccccc3)c(C)oc2c2ccccc12,4.7497200000000035
+80386,Modify the molecule COc1cc(C(=O)NNC(=O)c2cc(-c3ccccc3)[nH]n2)cc(OC)c1C to have a lower LogP value.,COc1cc(C(=O)NNC(=O)c2cc(-c3ccccc3)[nH]n2)cc(OC)c1C,2.47712
+587,Optimize the molecule O=C(Nc1cccc2ccccc12)NC1CC[NH+](CC(F)F)CC1 to have a lower LogP value.,O=C(Nc1cccc2ccccc12)NC1CC[NH+](CC(F)F)CC1,2.2737
+89354,Please modify the molecule O=C(NCc1ccnc(OCC(F)F)c1)N1CCC[C@H]2CCC[C@H]21 to increase its LogP value.,O=C(NCc1ccnc(OCC(F)F)c1)N1CCC[C@H]2CCC[C@H]21,3.199600000000002
+74193,Please modify the molecule COCCO[C@@H](C)C(=O)N1CCC(OC2CCCCC2)CC1 to decrease its LogP value.,COCCO[C@@H](C)C(=O)N1CCC(OC2CCCCC2)CC1,2.3781999999999996
+216452,Modify the molecule CCC[NH2+][C@H](CC)c1ccc(-c2cscc2Br)cc1 to increase its LogP value.,CCC[NH2+][C@H](CC)c1ccc(-c2cscc2Br)cc1,4.602100000000003
+95803,Modify the molecule O=C(NCC#CCOc1ccc2c(c1)OCO2)c1cccc(Br)c1 to have a lower LogP value.,O=C(NCC#CCOc1ccc2c(c1)OCO2)c1cccc(Br)c1,2.990000000000002
+179010,Modify the molecule CCSc1sccc1[C@H]1C(C#N)=C(N)N(c2cc([N+](=O)[O-])ccc2C)C2=C1C(=O)CC(C)(C)C2 to have a lower LogP value.,CCSc1sccc1[C@H]1C(C#N)=C(N)N(c2cc([N+](=O)[O-])ccc2C)C2=C1C(=O)CC(C)(C)C2,6.017600000000004
+109877,Please optimize the molecule COc1ncccc1C(=O)N1CCN(CCNC(=O)c2ccsc2)CC1 to have a lower LogP value.,COc1ncccc1C(=O)N1CCN(CCNC(=O)c2ccsc2)CC1,1.3394999999999997
+105764,Please modify the molecule COC(=O)[C@@H]1C[NH+](Cc2ccc(F)cc2C)C[C@@H]1C to increase its LogP value.,COC(=O)[C@@H]1C[NH+](Cc2ccc(F)cc2C)C[C@@H]1C,0.9579199999999997
+234574,Modify the molecule COc1cccc(C(=O)Nc2ccc(NC(=O)[C@@H]3[C@@H](C(=O)[O-])[C@@H]4C=C[C@H]3C4)cc2)c1 to have a higher LogP value.,COc1cccc(C(=O)Nc2ccc(NC(=O)[C@@H]3[C@@H](C(=O)[O-])[C@@H]4C=C[C@H]3C4)cc2)c1,2.0741999999999994
+93491,Optimize the molecule Cc1ccc([N+](=O)[O-])c(C)c1NC(=O)NCCCN1C[C@H](C)O[C@@H](C)C1 to have a lower LogP value.,Cc1ccc([N+](=O)[O-])c(C)c1NC(=O)NCCCN1C[C@H](C)O[C@@H](C)C1,2.832440000000001
+35436,Modify the molecule C[C@@H](C(=O)Nc1ccc(Cc2nc3ccccc3s2)cc1)[NH+]1CCN(c2ccc(O)cc2)CC1 to increase its LogP value.,C[C@@H](C(=O)Nc1ccc(Cc2nc3ccccc3s2)cc1)[NH+]1CCN(c2ccc(O)cc2)CC1,3.3248000000000015
+82562,Please modify the molecule Cc1cc(=O)n(CC(=O)Nc2ccc(C)c(Cl)c2)c(-n2nc(C)cc2C)n1 to increase its LogP value.,Cc1cc(=O)n(CC(=O)Nc2ccc(C)c(Cl)c2)c(-n2nc(C)cc2C)n1,2.9547800000000013
+194624,Optimize the molecule Cc1nn(C)c(Oc2cccc(-n3ccnc3)c2)c1[N+](=O)[O-] to have a higher LogP value.,Cc1nn(C)c(Oc2cccc(-n3ccnc3)c2)c1[N+](=O)[O-],2.614720000000001
+7194,Please optimize the molecule CCCNC(=O)NCC(=O)N1CCC(Cc2ccccc2)CC1 to have a lower LogP value.,CCCNC(=O)NCC(=O)N1CCC(Cc2ccccc2)CC1,2.176899999999999
+193400,Please optimize the molecule N#CCNC(=O)CN1C(=O)CCCc2cc(N)ccc21 to have a higher LogP value.,N#CCNC(=O)CN1C(=O)CCCc2cc(N)ccc21,0.5778799999999998
+84068,Modify the molecule COc1ccc(OC)c(NC(=O)CSc2nc3sc(C)c(C)c3c(=O)[nH]2)c1 to increase its LogP value.,COc1ccc(OC)c(NC(=O)CSc2nc3sc(C)c(C)c3c(=O)[nH]2)c1,3.3494400000000013
+232649,Please modify the molecule C=CCOc1ccc(C(=O)N2Cc3ccccc3C[C@H]2C(N)=O)cc1 to increase its LogP value.,C=CCOc1ccc(C(=O)N2Cc3ccccc3C[C@H]2C(N)=O)cc1,2.3038
+75719,Please optimize the molecule COc1ccc(CN[C@H](C)[C@H]2CCC[NH+](C)C2)cn1 to have a higher LogP value.,COc1ccc(CN[C@H](C)[C@H]2CCC[NH+](C)C2)cn1,0.49300000000000105
+239115,Modify the molecule CN(CC(=O)N[C@@H]1CCS(=O)(=O)C1)C(=O)Cc1cccc(Cl)c1 to increase its LogP value.,CN(CC(=O)N[C@@H]1CCS(=O)(=O)C1)C(=O)Cc1cccc(Cl)c1,0.6442000000000001
+182797,Modify the molecule CCn1cc(/C=c2/sc3n(c2=O)[C@H](c2cccs2)C(C(=O)Nc2ccccc2)=C(C)N=3)cn1 to increase its LogP value.,CCn1cc(/C=c2/sc3n(c2=O)[C@H](c2cccs2)C(C(=O)Nc2ccccc2)=C(C)N=3)cn1,3.1518000000000015
+146793,Optimize the molecule C[C@@H]1CCC[C@@H](C)N1C(=O)Cn1nc(-c2ccc(F)cc2)oc1=O to have a lower LogP value.,C[C@@H]1CCC[C@@H](C)N1C(=O)Cn1nc(-c2ccc(F)cc2)oc1=O,2.4319000000000006
+215501,Modify the molecule CCc1ccc(OCC(=O)N/N=C/c2ccc(Br)s2)cc1 to have a lower LogP value.,CCc1ccc(OCC(=O)N/N=C/c2ccc(Br)s2)cc1,3.602100000000002
+175574,Modify the molecule Nn1c([S-])nnc1CN1CCN(c2ccccc2)CC1 to increase its LogP value.,Nn1c([S-])nnc1CN1CCN(c2ccccc2)CC1,0.21989999999999976
+201120,Optimize the molecule CS[C@H]1CCC[C@H]1[NH+](C)CC1(CO)COC1 to have a lower LogP value.,CS[C@H]1CCC[C@H]1[NH+](C)CC1(CO)COC1,-0.20589999999999842
+47361,Please modify the molecule CCN(Cc1ccccn1)C(=O)NCc1ccc(C(C)(C)C)cc1 to increase its LogP value.,CCN(Cc1ccccn1)C(=O)NCc1ccc(C(C)(C)C)cc1,4.110800000000003
+32926,Optimize the molecule Cc1cccc(CN2CCN(CC(=O)N3CCC(C)CC3)C(=O)C2=O)c1 to have a higher LogP value.,Cc1cccc(CN2CCN(CC(=O)N3CCC(C)CC3)C(=O)C2=O)c1,1.4243199999999998
+179323,Please modify the molecule OC[C@@]1(CCc2ccccc2)CCC[NH+](Cc2cnc(N3CCOCC3)s2)C1 to decrease its LogP value.,OC[C@@]1(CCc2ccccc2)CCC[NH+](Cc2cnc(N3CCOCC3)s2)C1,1.7698999999999996
+76920,Please modify the molecule O=C1CN(C(=O)c2cc3ccccc3[nH]c2=O)CCN1 to decrease its LogP value.,O=C1CN(C(=O)c2cc3ccccc3[nH]c2=O)CCN1,0.10010000000000013
+70755,Modify the molecule COc1ccc2cc(/C([O-])=C(/C#N)C(=O)N3CCCC3)c(C)nc2c1 to have a lower LogP value.,COc1ccc2cc(/C([O-])=C(/C#N)C(=O)N3CCCC3)c(C)nc2c1,1.7691999999999999
+18510,Optimize the molecule O=C(C[C@@H](O)c1ccccc1)NCc1ccc(-c2cccnc2)cc1 to have a lower LogP value.,O=C(C[C@@H](O)c1ccccc1)NCc1ccc(-c2cccnc2)cc1,3.488500000000002
+18764,Optimize the molecule CCc1ccc(NS(=O)(=O)c2cc(-c3c(C)noc3C)ccc2C)cc1 to have a higher LogP value.,CCc1ccc(NS(=O)(=O)c2cc(-c3c(C)noc3C)ccc2C)cc1,4.630060000000004
+62111,Please optimize the molecule CCN(C(=O)Nc1cc(NC(C)=O)c(F)cc1F)[C@H](C)c1cccc(OC)c1 to have a lower LogP value.,CCN(C(=O)Nc1cc(NC(C)=O)c(F)cc1F)[C@H](C)c1cccc(OC)c1,4.546800000000003
+94313,Please modify the molecule O=C(CNC(=O)c1cccc(F)c1)OCC(=O)N1CCCc2ccccc21 to increase its LogP value.,O=C(CNC(=O)c1cccc(F)c1)OCC(=O)N1CCCc2ccccc21,2.0781
+72997,Modify the molecule CCc1cccc(C(=O)N2CCN(Cc3ccncc3)CC2)c1O to increase its LogP value.,CCc1cccc(C(=O)N2CCN(Cc3ccncc3)CC2)c1O,2.3076000000000003
+60299,Modify the molecule Cc1noc(Cl)c1CC(=O)N[C@H](C)Cc1c(Cl)cccc1Cl to increase its LogP value.,Cc1noc(Cl)c1CC(=O)N[C@H](C)Cc1c(Cl)cccc1Cl,4.233120000000002
+10373,Please modify the molecule C[C@@H](NS(=O)(=O)c1cccc2cnccc12)c1ccccc1 to increase its LogP value.,C[C@@H](NS(=O)(=O)c1cccc2cnccc12)c1ccccc1,3.274300000000002
+139490,Please modify the molecule CSc1ccc2c(c1)CCN(C(=O)c1c(C)cc(C)[nH]c1=O)C2 to increase its LogP value.,CSc1ccc2c(c1)CCN(C(=O)c1c(C)cc(C)[nH]c1=O)C2,2.912140000000001
+15488,Optimize the molecule Fc1ccc([C@@H](Cl)Cc2nc3ccccc3o2)c(F)c1F to have a lower LogP value.,Fc1ccc([C@@H](Cl)Cc2nc3ccccc3o2)c(F)c1F,4.767700000000002
+117619,Modify the molecule CCOC(=O)c1sc(NC(=O)CCC(=O)[O-])c(C#N)c1C to increase its LogP value.,CCOC(=O)c1sc(NC(=O)CCC(=O)[O-])c(C#N)c1C,0.5734999999999997
+27411,Please modify the molecule CCn1cnnc1-c1cccc(NC(=O)[C@@H]2CC(=O)N(CC[NH+](C)C)C2)c1 to decrease its LogP value.,CCn1cnnc1-c1cccc(NC(=O)[C@@H]2CC(=O)N(CC[NH+](C)C)C2)c1,-0.10349999999999815
+227566,Modify the molecule O=C(C[NH+]1CC[C@@H](O)C1)Nc1cc(F)ccc1F to have a lower LogP value.,O=C(C[NH+]1CC[C@@H](O)C1)Nc1cc(F)ccc1F,-0.44720000000000004
+56388,Please modify the molecule C[C@H](NC(=O)[C@@H](C)Sc1ccccc1)c1ccc2c(c1)CCC(=O)N2 to decrease its LogP value.,C[C@H](NC(=O)[C@@H](C)Sc1ccccc1)c1ccc2c(c1)CCC(=O)N2,3.9293000000000022
+14851,Please optimize the molecule Cc1ccc(-c2cc(C(F)(F)F)n3nc(C(=O)N4CCN(C)CC4)cc3n2)cc1 to have a higher LogP value.,Cc1ccc(-c2cc(C(F)(F)F)n3nc(C(=O)N4CCN(C)CC4)cc3n2)cc1,3.1111200000000014
+97625,Modify the molecule C[C@H](Oc1ccc(Cl)cc1Br)C(=O)NNC(=O)c1cccc([N+](=O)[O-])c1 to decrease its LogP value.,C[C@H](Oc1ccc(Cl)cc1Br)C(=O)NNC(=O)c1cccc([N+](=O)[O-])c1,3.2392000000000003
+51455,Optimize the molecule Cc1cccc(-n2nnnc2SCC(=O)N(C)[C@@H]2CCCc3ccccc32)c1 to have a higher LogP value.,Cc1cccc(-n2nnnc2SCC(=O)N(C)[C@@H]2CCCc3ccccc32)c1,3.5988200000000026
+97056,Please optimize the molecule Cc1nn(C)c2ncc(NC(=O)N(C)[C@H](C)CS(C)(=O)=O)cc12 to have a higher LogP value.,Cc1nn(C)c2ncc(NC(=O)N(C)[C@H](C)CS(C)(=O)=O)cc12,1.17352
+89674,Modify the molecule CC[NH2+]C[C@@H](CC1CCOCC1)c1cccc(Cl)c1 to decrease its LogP value.,CC[NH2+]C[C@@H](CC1CCOCC1)c1cccc(Cl)c1,2.8236000000000008
+223537,Please modify the molecule C[C@H]([NH3+])[C@H](c1ccsc1)N1CCO[C@H](C#N)C1 to increase its LogP value.,C[C@H]([NH3+])[C@H](c1ccsc1)N1CCO[C@H](C#N)C1,0.6439799999999996
+67394,Please modify the molecule NC(=O)c1ccc(NC(=O)NCc2ccc(F)cc2)c(F)c1 to decrease its LogP value.,NC(=O)c1ccc(NC(=O)NCc2ccc(F)cc2)c(F)c1,2.3853999999999997
+35562,Please optimize the molecule Cc1n[nH]c(C)c1C[C@H](C)C(=O)N1CCCCC[C@H]1CC(C)C to have a lower LogP value.,Cc1n[nH]c(C)c1C[C@H](C)C(=O)N1CCCCC[C@H]1CC(C)C,4.022440000000003
+135492,Modify the molecule COc1cc(Br)ccc1S(=O)(=O)NCc1cccnc1 to have a lower LogP value.,COc1cc(Br)ccc1S(=O)(=O)NCc1cccnc1,2.3312
+176002,Modify the molecule CC(C)(C)c1ccc(C=C2C[NH2+]C2)cc1 to increase its LogP value.,CC(C)(C)c1ccc(C=C2C[NH2+]C2)cc1,1.9445000000000001
+148467,Modify the molecule NS(=O)(=O)c1ccc(NC(=O)CSC2=NC(=O)C3=C4CCCC[C@H]4SC3=N2)cc1 to have a higher LogP value.,NS(=O)(=O)c1ccc(NC(=O)CSC2=NC(=O)C3=C4CCCC[C@H]4SC3=N2)cc1,2.2864000000000004
+177584,Modify the molecule CN1C(=O)C(=Cc2ccc(OCc3ccc([N+](=O)[O-])cc3)c(Br)c2)C(=O)N(C)C1=O to have a higher LogP value.,CN1C(=O)C(=Cc2ccc(OCc3ccc([N+](=O)[O-])cc3)c(Br)c2)C(=O)N(C)C1=O,3.3701000000000025
+25246,Please optimize the molecule CN(C(=O)c1ccc(-c2ccco2)[nH]c1=O)c1ccc(Oc2ccccc2)cc1 to have a lower LogP value.,CN(C(=O)c1ccc(-c2ccco2)[nH]c1=O)c1ccc(Oc2ccccc2)cc1,4.703800000000004
+194749,Modify the molecule CC[C@]1(C)C[C@@H]([C@H](Br)C(C)C)CCO1 to decrease its LogP value.,CC[C@]1(C)C[C@@H]([C@H](Br)C(C)C)CCO1,4.001200000000003
+164063,Please modify the molecule O=C(N[C@@H]1CC[NH+]2CCCC[C@H]12)C(c1ccccc1)c1ccccc1 to decrease its LogP value.,O=C(N[C@@H]1CC[NH+]2CCCC[C@H]12)C(c1ccccc1)c1ccccc1,2.1444
+45264,Modify the molecule Cc1cccc(-n2nnnc2SC[C@@H]2CNC(=O)O2)c1C to have a higher LogP value.,Cc1cccc(-n2nnnc2SC[C@@H]2CNC(=O)O2)c1C,1.47964
+158895,Please modify the molecule O=C(Nc1ccc(-n2cccn2)cc1)c1nc[nH]n1 to increase its LogP value.,O=C(Nc1ccc(-n2cccn2)cc1)c1nc[nH]n1,1.2426999999999997
+42910,Please modify the molecule C[C@H]1CCC[C@@]1(C[NH3+])Sc1ccccc1 to decrease its LogP value.,C[C@H]1CCC[C@@]1(C[NH3+])Sc1ccccc1,2.5794000000000006
+226918,Optimize the molecule CCNC(=O)NNC(=O)CSc1cccc2cccc(Cl)c12 to have a higher LogP value.,CCNC(=O)NNC(=O)CSc1cccc2cccc(Cl)c12,2.9356000000000018
+20387,Please modify the molecule Cc1nn(C[C@@H]2Cc3ccccc3S2)cc1C[NH3+] to decrease its LogP value.,Cc1nn(C[C@@H]2Cc3ccccc3S2)cc1C[NH3+],1.6504199999999996
+69142,Please optimize the molecule CN(Cc1ccc(OC(F)(F)F)cc1)C(=O)NCC#Cc1ccccc1 to have a higher LogP value.,CN(Cc1ccc(OC(F)(F)F)cc1)C(=O)NCC#Cc1ccccc1,3.7783000000000024
+183346,Modify the molecule CCCNC(=O)CN(C)C(=O)[C@@H]1CC[NH2+][C@H]1C to have a lower LogP value.,CCCNC(=O)CN(C)C(=O)[C@@H]1CC[NH2+][C@H]1C,-1.0571999999999966
+155693,Please optimize the molecule COc1cccc(C(=O)Nc2sc(SC)nc2-c2ccccc2)c1OC to have a lower LogP value.,COc1cccc(C(=O)Nc2sc(SC)nc2-c2ccccc2)c1OC,4.801500000000003
+133581,Please modify the molecule O=C1c2ccccc2S(=O)(=O)N1CNc1cccc(C(F)(F)F)c1 to decrease its LogP value.,O=C1c2ccccc2S(=O)(=O)N1CNc1cccc(C(F)(F)F)c1,2.919500000000001
+134667,Please modify the molecule CCn1c(N)c(C(=O)C[NH+]2CCC(C)CC2)c(=O)[nH]c1=O to decrease its LogP value.,CCn1c(N)c(C(=O)C[NH+]2CCC(C)CC2)c(=O)[nH]c1=O,-1.3637999999999977
+54704,Modify the molecule CN(CCc1cccs1)[C@H](C[NH3+])c1cc(F)c(F)c(F)c1 to decrease its LogP value.,CN(CCc1cccs1)[C@H](C[NH3+])c1cc(F)c(F)c(F)c1,2.6229000000000005
+173887,Optimize the molecule CCOC(=O)c1cccc(N[C@@H](C)[C@H]2CCCO2)n1 to have a higher LogP value.,CCOC(=O)c1cccc(N[C@@H](C)[C@H]2CCCO2)n1,2.2377000000000002
+146576,Please modify the molecule ON(c1ccccc1)[C@H](Br)[C@@H](Br)c1ccccc1 to decrease its LogP value.,ON(c1ccccc1)[C@H](Br)[C@@H](Br)c1ccccc1,4.739400000000003
+166433,Modify the molecule O=C1/C(=C\c2ccc(-c3ccc(Cl)cc3)o2)NC(=S)N1c1ccccc1 to have a higher LogP value.,O=C1/C(=C\c2ccc(-c3ccc(Cl)cc3)o2)NC(=S)N1c1ccccc1,4.862200000000003
+215424,Please modify the molecule Cc1ccc2c(NC(=O)c3cc(-c4ccccc4Cl)no3)n[nH]c2n1 to decrease its LogP value.,Cc1ccc2c(NC(=O)c3cc(-c4ccccc4Cl)no3)n[nH]c2n1,3.827020000000001
+203003,Modify the molecule CC[C@@H]([NH2+][C@H](c1ccccc1)C(C)C)c1nc(C)cs1 to increase its LogP value.,CC[C@@H]([NH2+][C@H](c1ccccc1)C(C)C)c1nc(C)cs1,3.8633200000000034
+78125,Please modify the molecule CC(C)C[C@@H]1CNC(=[NH2+])N1c1ccccc1Cl to decrease its LogP value.,CC(C)C[C@@H]1CNC(=[NH2+])N1c1ccccc1Cl,1.2794000000000003
+204648,Please modify the molecule CN(C)C(=O)C[NH+](C)CC(=O)NC1CCCCCCC1 to increase its LogP value.,CN(C)C(=O)C[NH+](C)CC(=O)NC1CCCCCCC1,-0.18159999999999754
+221671,Please optimize the molecule CCOc1ccccc1C(=O)N[C@H](C(=O)N1CCCC[C@@H]1C)C(C)C to have a higher LogP value.,CCOc1ccccc1C(=O)N[C@H](C(=O)N1CCCC[C@@H]1C)C(C)C,3.240700000000002
+64234,Modify the molecule O=C1[C@@H]2[C@H](C(=O)N1c1ccccc1F)C1c3ccccc3C2(Cl)c2ccccc21 to have a lower LogP value.,O=C1[C@@H]2[C@H](C(=O)N1c1ccccc1F)C1c3ccccc3C2(Cl)c2ccccc21,4.5728000000000035
+115211,Modify the molecule NC(=S)N1N=C(c2ccccc2)C[C@H]1c1cccs1 to increase its LogP value.,NC(=S)N1N=C(c2ccccc2)C[C@H]1c1cccs1,3.142800000000002
+81329,Optimize the molecule Cc1ccc(CCNC(=O)c2cc3sccc3n2CCc2ccccc2)o1 to have a higher LogP value.,Cc1ccc(CCNC(=O)c2cc3sccc3n2CCc2ccccc2)o1,4.819420000000004
+215194,Please modify the molecule Cc1ccoc1[C@@H](C)[NH2+][C@H](C)c1cccc([N-]S(C)(=O)=O)c1 to increase its LogP value.,Cc1ccoc1[C@@H](C)[NH2+][C@H](C)c1cccc([N-]S(C)(=O)=O)c1,2.9384200000000016
+121714,Please optimize the molecule C=CCN(C(=O)[C@H](C)S(C)(=O)=O)c1nc(-c2ccccc2)cs1 to have a higher LogP value.,C=CCN(C(=O)[C@H](C)S(C)(=O)=O)c1nc(-c2ccccc2)cs1,2.7622000000000018
+98694,Modify the molecule CCc1n[nH]c(SCCCOc2ccc(C#N)cc2)n1 to have a lower LogP value.,CCc1n[nH]c(SCCCOc2ccc(C#N)cc2)n1,2.7999800000000015
+212741,Modify the molecule Cc1ccc([C@H](N)CCN2CCOC(C)(C)C2)cc1F to have a lower LogP value.,Cc1ccc([C@H](N)CCN2CCOC(C)(C)C2)cc1F,2.6348200000000013
+218200,Please optimize the molecule Cn1nc(NC(=O)c2ccc(C(F)(F)F)cc2)c2c1NC(=O)C[C@H]2c1ccco1 to have a higher LogP value.,Cn1nc(NC(=O)c2ccc(C(F)(F)F)cc2)c2c1NC(=O)C[C@H]2c1ccco1,3.758300000000001
+133704,Please modify the molecule Cc1ccccc1N1CCN(C(=O)/C=C/c2cnn(C)c2)[C@H](C)C1 to increase its LogP value.,Cc1ccccc1N1CCN(C(=O)/C=C/c2cnn(C)c2)[C@H](C)C1,2.4790200000000002
+124583,Optimize the molecule C[C@@H](CO)C[NH2+][C@@H]1CCOC2(CCOCC2)C1 to have a higher LogP value.,C[C@@H](CO)C[NH2+][C@@H]1CCOC2(CCOCC2)C1,-0.09359999999999924
+70691,Optimize the molecule Cc1c([C@@H](C)NC(=O)c2ccc(NS(C)(=O)=O)cc2)cnn1C to have a higher LogP value.,Cc1c([C@@H](C)NC(=O)c2ccc(NS(C)(=O)=O)cc2)cnn1C,1.5910199999999999
+98249,Modify the molecule CCOC(=O)c1ccccc1NC(=O)c1ccccc1 to decrease its LogP value.,CCOC(=O)c1ccccc1NC(=O)c1ccccc1,3.1156000000000015
+169188,Optimize the molecule Cc1cc(C(=O)NCCCOc2ccccc2)no1 to have a higher LogP value.,Cc1cc(C(=O)NCCCOc2ccccc2)no1,2.18192
+230769,Please optimize the molecule COc1cccc(-c2nnc(S[C@H]3CCCC[C@@H]3O)n2N)c1 to have a higher LogP value.,COc1cccc(-c2nnc(S[C@H]3CCCC[C@@H]3O)n2N)c1,2.0630999999999995
+35244,Please modify the molecule CCc1c(C(=O)/C=C/c2ccc(NC(C)=O)cc2)oc2ccccc12 to decrease its LogP value.,CCc1c(C(=O)/C=C/c2ccc(NC(C)=O)cc2)oc2ccccc12,4.849700000000004
+80764,Please optimize the molecule CCOc1ccccc1NC(=O)Cc1c(C)nc2nc(SC)nn2c1C to have a higher LogP value.,CCOc1ccccc1NC(=O)Cc1c(C)nc2nc(SC)nn2c1C,3.0429400000000015
+101954,Please optimize the molecule Cc1cc(S(N)(=O)=O)cc(NC(=O)CSCc2ccccc2)c1C to have a higher LogP value.,Cc1cc(S(N)(=O)=O)cc(NC(=O)CSCc2ccccc2)c1C,2.8227400000000014
+207418,Modify the molecule Nc1ccc2oc(NCc3ccsc3)nc2c1 to increase its LogP value.,Nc1ccc2oc(NCc3ccsc3)nc2c1,3.0836000000000006
+32824,Please optimize the molecule Nc1cc(-c2cccs2)no1 to have a lower LogP value.,Nc1cc(-c2cccs2)no1,1.9852999999999998
+2106,Modify the molecule COC(=O)Cn1cc(/C=C2/C(=O)N(c3cccc(F)c3)C(=O)N=C2[O-])c2ccccc21 to have a higher LogP value.,COC(=O)Cn1cc(/C=C2/C(=O)N(c3cccc(F)c3)C(=O)N=C2[O-])c2ccccc21,2.2624000000000004
+60874,Please modify the molecule CN(C(=O)c1ccc(N2CCCC2)nc1)[C@@H]1CCc2ccccc2C1 to decrease its LogP value.,CN(C(=O)c1ccc(N2CCCC2)nc1)[C@@H]1CCc2ccccc2C1,3.311300000000002
+23865,Optimize the molecule CSc1ccc(O[C@@H](C)C(=O)Nc2c(C)cnn2-c2ccccc2)cc1 to have a lower LogP value.,CSc1ccc(O[C@@H](C)C(=O)Nc2c(C)cnn2-c2ccccc2)cc1,4.308620000000003
+9009,Please optimize the molecule CCOC(=O)C1=C(C)/C(=N\Nc2ccc(F)cc2)N=C1C to have a lower LogP value.,CCOC(=O)C1=C(C)/C(=N\Nc2ccc(F)cc2)N=C1C,2.9052000000000016
+21467,Modify the molecule O=C(CN1C(=O)[C@H]2[C@@H]3C=C[C@@H](C3)[C@@H]2C1=O)N1CCN(c2ccccc2Cl)CC1 to have a lower LogP value.,O=C(CN1C(=O)[C@H]2[C@@H]3C=C[C@@H](C3)[C@@H]2C1=O)N1CCN(c2ccccc2Cl)CC1,1.7956999999999999
+229891,Please modify the molecule CC[C@H](C)c1ccccc1OCC[NH+]1CCOCC1 to increase its LogP value.,CC[C@H](C)c1ccccc1OCC[NH+]1CCOCC1,1.4939999999999996
+81386,Modify the molecule Cc1cncc(NC(=O)c2cc3cc(C)ccc3nc2C)c1 to have a higher LogP value.,Cc1cncc(NC(=O)c2cc3cc(C)ccc3nc2C)c1,3.807360000000002
+149677,Modify the molecule Fc1cccc2c1OCC[C@H]2NCc1nncn1C1CC1 to have a higher LogP value.,Fc1cccc2c1OCC[C@H]2NCc1nncn1C1CC1,2.3655
+134302,Modify the molecule CC[C@@H](C)n1c([C@@H]2CCC[NH2+]2)nc2cc(C(F)(F)F)ccc21 to increase its LogP value.,CC[C@@H](C)n1c([C@@H]2CCC[NH2+]2)nc2cc(C(F)(F)F)ccc21,3.424400000000001
+36195,Modify the molecule CC(C)(C)C(=O)COC(=O)c1cc2ccccc2cc1O to have a lower LogP value.,CC(C)(C)C(=O)COC(=O)c1cc2ccccc2cc1O,3.3174000000000023
+10361,Optimize the molecule c1ccc2c(c1)C[C@H](C[NH2+]C(C1CC1)C1CC1)S2 to have a lower LogP value.,c1ccc2c(c1)C[C@H](C[NH2+]C(C1CC1)C1CC1)S2,2.4554
+170686,Please modify the molecule Cc1ccc(S(=O)(=O)Nc2ccc(C(=O)N(C)C)cc2)cc1[N+](=O)[O-] to decrease its LogP value.,Cc1ccc(S(=O)(=O)Nc2ccc(C(=O)N(C)C)cc2)cc1[N+](=O)[O-],2.4058200000000003
+192980,Please optimize the molecule Cc1ccc(NC(=O)c2cc(S(=O)(=O)c3ccccc3)ccc2Cl)cc1 to have a higher LogP value.,Cc1ccc(NC(=O)c2cc(S(=O)(=O)c3ccccc3)ccc2Cl)cc1,4.733520000000003
+169024,Please modify the molecule CC(C)c1noc(CN2C(=O)[C@H](C)N(c3ccc(F)cc3)C2=O)n1 to decrease its LogP value.,CC(C)c1noc(CN2C(=O)[C@H](C)N(c3ccc(F)cc3)C2=O)n1,2.689400000000001
+178775,Modify the molecule COc1ccc([C@@H]2CN(C(=O)c3cc(=O)[nH]c([O-])n3)C[C@H]2NC(C)=O)cc1 to increase its LogP value.,COc1ccc([C@@H]2CN(C(=O)c3cc(=O)[nH]c([O-])n3)C[C@H]2NC(C)=O)cc1,-0.4035999999999986
+211923,Modify the molecule CCNC(=O)c1ccc(CNS(=O)(=O)c2ccccc2Cl)cc1 to have a higher LogP value.,CCNC(=O)c1ccc(CNS(=O)(=O)c2ccccc2Cl)cc1,2.568200000000001
+138467,Please modify the molecule Cc1nn(C)c2sc(C(=O)Nc3ccc(OCC[NH+](C)C)cc3)cc12 to decrease its LogP value.,Cc1nn(C)c2sc(C(=O)Nc3ccc(OCC[NH+](C)C)cc3)cc12,1.7188199999999993
+136023,Optimize the molecule COc1ccccc1Nc1nc2ccc(N)cc2[nH]1 to have a higher LogP value.,COc1ccccc1Nc1nc2ccc(N)cc2[nH]1,2.8972999999999995
+129878,Please modify the molecule C[C@@H](NC(=O)c1cc2c(s1)CCC2)c1ccc(-n2cncn2)cc1 to increase its LogP value.,C[C@@H](NC(=O)c1cc2c(s1)CCC2)c1ccc(-n2cncn2)cc1,3.3085000000000013
+109949,Please optimize the molecule Cc1c(F)cccc1NCc1cc(Cl)cc2c1OCOC2 to have a higher LogP value.,Cc1c(F)cccc1NCc1cc(Cl)cc2c1OCOC2,4.266120000000003
+221070,Modify the molecule C[NH+](C)CCCNS(=O)(=O)Cc1ccc(Cl)c(Cl)c1 to have a lower LogP value.,C[NH+](C)CCCNS(=O)(=O)Cc1ccc(Cl)c(Cl)c1,0.9474000000000007
+232555,Optimize the molecule CC(=O)NS(=O)(=O)c1ccc(NC(=O)C2CCN(c3ccccc3)CC2)cc1 to have a higher LogP value.,CC(=O)NS(=O)(=O)c1ccc(NC(=O)C2CCN(c3ccccc3)CC2)cc1,2.3665000000000003
+40986,Optimize the molecule CN(C)S(=O)(=O)c1ccc(N2CCO[C@@H](C#N)C2)c(N)c1 to have a higher LogP value.,CN(C)S(=O)(=O)c1ccc(N2CCO[C@@H](C#N)C2)c(N)c1,0.24788000000000066
+155281,Optimize the molecule O=C1[C@@H](c2ccsc2)N(c2ccc(Cl)cc2)C(=O)CN1c1ccccc1F to have a higher LogP value.,O=C1[C@@H](c2ccsc2)N(c2ccc(Cl)cc2)C(=O)CN1c1ccccc1F,4.661700000000003
+86270,Optimize the molecule CC(C)CNC(=O)NC(=O)Cn1nnc2ccccc2c1=O to have a lower LogP value.,CC(C)CNC(=O)NC(=O)Cn1nnc2ccccc2c1=O,0.27329999999999927
+112756,Please optimize the molecule Cc1cc(=O)n(CC(=O)Nc2cccc(C)c2C)c(-c2cccc(Cl)c2)n1 to have a higher LogP value.,Cc1cc(=O)n(CC(=O)Nc2cccc(C)c2C)c(-c2cccc(Cl)c2)n1,4.127660000000003
+98232,Optimize the molecule CCCc1cc(OCC(=O)[O-])nc(Nc2ccc(C#N)cc2)n1 to have a lower LogP value.,CCCc1cc(OCC(=O)[O-])nc(Nc2ccc(C#N)cc2)n1,1.1730799999999997
+118157,Optimize the molecule Cc1oc(C(=O)NCCn2cccc2)cc1S(=O)(=O)N(C)C to have a lower LogP value.,Cc1oc(C(=O)NCCn2cccc2)cc1S(=O)(=O)N(C)C,1.06982
+245833,Please modify the molecule C[C@H](O)CN(C)C(=O)NCCCC[NH+]1CCCC1 to increase its LogP value.,C[C@H](O)CN(C)C(=O)NCCCC[NH+]1CCCC1,-0.5324999999999978
+244880,Optimize the molecule CCOc1ccc(-n2c(C)c(C)c3c2ncn2nc(-c4ccccc4O)nc32)cc1 to have a higher LogP value.,CCOc1ccc(-n2c(C)c(C)c3c2ncn2nc(-c4ccccc4O)nc32)cc1,4.456340000000004
+208738,Optimize the molecule Cc1cc([C@@H](C)NC(=O)NNC(=O)c2cccc(N(C)C)c2)c(C)s1 to have a lower LogP value.,Cc1cc([C@@H](C)NC(=O)NNC(=O)c2cccc(N(C)C)c2)c(C)s1,3.136140000000002
+30212,Please modify the molecule C/C(=C\CC[NH3+])C[C@@H]1CCCO1 to increase its LogP value.,C/C(=C\CC[NH3+])C[C@@H]1CCCO1,1.1338
+22277,Please optimize the molecule CC(C)NC(=O)c1ccc(NCC(=O)NCc2ccccc2F)cc1 to have a lower LogP value.,CC(C)NC(=O)c1ccc(NCC(=O)NCc2ccccc2F)cc1,2.6922000000000006
+203863,Please modify the molecule CCOC1CC[NH+](CC[C@H]2CCC[C@H]2O)CC1 to increase its LogP value.,CCOC1CC[NH+](CC[C@H]2CCC[C@H]2O)CC1,0.6213000000000006
+198195,Please optimize the molecule Cc1cc2c(cc1C)[C@@H](c1cc([N+](=O)[O-])ccc1Cl)CC(=O)N2 to have a lower LogP value.,Cc1cc2c(cc1C)[C@@H](c1cc([N+](=O)[O-])ccc1Cl)CC(=O)N2,4.339140000000003
+240773,Modify the molecule Cc1nn(CC(=O)N(C[C@@H]2CCOC2)C2CC2)c(=O)c2ccccc12 to decrease its LogP value.,Cc1nn(CC(=O)N(C[C@@H]2CCOC2)C2CC2)c(=O)c2ccccc12,1.7324199999999996
+173848,Please optimize the molecule C[C@H]1CCCCN1C(=O)NCc1ncnn1C to have a lower LogP value.,C[C@H]1CCCCN1C(=O)NCc1ncnn1C,0.8990999999999998
+64315,Please optimize the molecule C[C@H]1CN(c2ccc(CNS(=O)(=O)Cc3ccccc3)c[nH+]2)C[C@H](C)O1 to have a lower LogP value.,C[C@H]1CN(c2ccc(CNS(=O)(=O)Cc3ccccc3)c[nH+]2)C[C@H](C)O1,1.7339000000000002
+28992,Modify the molecule CCOC(=O)c1ccc(/N=C2\NC(=O)S\C2=C/c2ccc(OC)cc2)cc1 to increase its LogP value.,CCOC(=O)c1ccc(/N=C2\NC(=O)S\C2=C/c2ccc(OC)cc2)cc1,4.399400000000003
+78321,Optimize the molecule C[C@H](NC(=O)C(C)(C)C)C(=O)N[C@@H](CC(N)=O)C1CCCCC1 to have a lower LogP value.,C[C@H](NC(=O)C(C)(C)C)C(=O)N[C@@H](CC(N)=O)C1CCCCC1,1.4776999999999998
+124608,Please modify the molecule COc1ccc(Cl)cc1C1(CNS(=O)(=O)c2cccs2)CCOCC1 to decrease its LogP value.,COc1ccc(Cl)cc1C1(CNS(=O)(=O)c2cccs2)CCOCC1,3.4368000000000025
+132266,Modify the molecule CSCC[C@@H](NC(=O)C1=Cc2cc(Cl)ccc2OC1)c1nc2ccccc2[nH]1 to decrease its LogP value.,CSCC[C@@H](NC(=O)C1=Cc2cc(Cl)ccc2OC1)c1nc2ccccc2[nH]1,4.602700000000003
+19166,Optimize the molecule COc1ccc2c(c1)[C@H](N)[C@H]([NH+](C)CC(C)(C)C)CC2 to have a lower LogP value.,COc1ccc2c(c1)[C@H](N)[C@H]([NH+](C)CC(C)(C)C)CC2,1.5705999999999998
+56736,Please optimize the molecule C[C@@H](Oc1ccc(Cl)cc1)C(=O)NNC(=O)Cn1ccc2ccccc21 to have a lower LogP value.,C[C@@H](Oc1ccc(Cl)cc1)C(=O)NNC(=O)Cn1ccc2ccccc21,2.909600000000001
+153684,Please modify the molecule CC(C)c1nnc(SCC(=O)Nc2nncs2)o1 to decrease its LogP value.,CC(C)c1nnc(SCC(=O)Nc2nncs2)o1,1.7752999999999999
+11288,Please modify the molecule N#Cc1ccc(OC(=O)c2ccccc2SCC(N)=O)c(Cl)c1 to increase its LogP value.,N#Cc1ccc(OC(=O)c2ccccc2SCC(N)=O)c(Cl)c1,3.008280000000001
+147628,Optimize the molecule C[NH2+][C@H](Cc1nc([C@@H]2CSCCS2)no1)C(C)(C)C to have a higher LogP value.,C[NH2+][C@H](Cc1nc([C@@H]2CSCCS2)no1)C(C)(C)C,1.7411000000000003
+213699,Please optimize the molecule CCC(CC)[NH+](CC(C)C)[C@@H]1CCC[C@@H]1C[NH3+] to have a higher LogP value.,CCC(CC)[NH+](CC(C)C)[C@@H]1CCC[C@@H]1C[NH3+],1.126500000000002
+126939,Please optimize the molecule C[NH2+]C[C@@H](Cc1ccccc1OC)c1cccc(F)c1 to have a lower LogP value.,C[NH2+]C[C@@H](Cc1ccccc1OC)c1cccc(F)c1,2.3538000000000006
+147526,Modify the molecule C[NH+](C)[C@@H]1CC[C@@H](NC(=O)N2CCN(c3nnnn3-c3ccccc3)CC2)C1 to have a higher LogP value.,C[NH+](C)[C@@H]1CC[C@@H](NC(=O)N2CCN(c3nnnn3-c3ccccc3)CC2)C1,-0.4404999999999968
+26153,Modify the molecule Cc1ccc(CC(=O)Nc2ccccc2Sc2nc(Br)nn2C)cc1 to have a higher LogP value.,Cc1ccc(CC(=O)Nc2ccccc2Sc2nc(Br)nn2C)cc1,4.218420000000003
+87353,Optimize the molecule CCc1cccc(C)c1NC(=O)[C@H](C)O/N=C(/N)Cc1ccccc1C to have a higher LogP value.,CCc1cccc(C)c1NC(=O)[C@H](C)O/N=C(/N)Cc1ccccc1C,3.7243400000000015
+170648,Optimize the molecule CNC(=O)[C@H]1CCC[NH+]1Cc1cc(Br)c(OC)s1 to have a higher LogP value.,CNC(=O)[C@H]1CCC[NH+]1Cc1cc(Br)c(OC)s1,0.8124999999999996
+244720,Please optimize the molecule N/C(=N\OCCCCC(F)(F)F)C(F)(F)F to have a lower LogP value.,N/C(=N\OCCCCC(F)(F)F)C(F)(F)F,2.570100000000001
+70638,Please optimize the molecule CCn1nc(C)c(CNC(=O)C(=O)Nc2ccc3cc[nH]c3c2)c1C to have a lower LogP value.,CCn1nc(C)c(CNC(=O)C(=O)Nc2ccc3cc[nH]c3c2)c1C,2.2560399999999996
+109916,Please modify the molecule C[C@H](CC(=O)[O-])NC(=O)[C@@H]1Cc2ccccc2O1 to increase its LogP value.,C[C@H](CC(=O)[O-])NC(=O)[C@@H]1Cc2ccccc2O1,-0.36519999999999886
+179459,Please modify the molecule COc1ccc([C@H](C)[NH2+]C[C@@]2(C)CCCO2)c(O)c1 to increase its LogP value.,COc1ccc([C@H](C)[NH2+]C[C@@]2(C)CCCO2)c(O)c1,1.5942999999999998
+239946,Modify the molecule O=C([O-])/C=C/c1cc(F)cc(CSc2ccncc2)c1 to increase its LogP value.,O=C([O-])/C=C/c1cc(F)cc(CSc2ccncc2)c1,2.2761000000000005
+163551,Please optimize the molecule Cc1ccc(NC(=O)[C@@H]2CC(=O)N(c3cccc(Cl)c3C)C2)cc1 to have a lower LogP value.,Cc1ccc(NC(=O)[C@@H]2CC(=O)N(c3cccc(Cl)c3C)C2)cc1,3.9484400000000024
+23036,Please optimize the molecule O=S(=O)(/N=C(\[O-])[C@H]1C[C@@H]1c1ccc(C(F)(F)F)cc1)c1cccs1 to have a lower LogP value.,O=S(=O)(/N=C(\[O-])[C@H]1C[C@@H]1c1ccc(C(F)(F)F)cc1)c1cccs1,3.0181000000000013
+53501,Please modify the molecule CC[NH+](CC)Cc1nc(-c2ccc(C(F)(F)F)cc2)no1 to increase its LogP value.,CC[NH+](CC)Cc1nc(-c2ccc(C(F)(F)F)cc2)no1,2.1801000000000004
+7694,Modify the molecule COc1ccc(C(=O)NNC(=O)c2ccc(Cn3nnc(-c4ccccc4)n3)cc2)cc1 to have a lower LogP value.,COc1ccc(C(=O)NNC(=O)c2ccc(Cn3nnc(-c4ccccc4)n3)cc2)cc1,2.4718
+139918,Please modify the molecule Cc1cnc2c(c1)nc(CCCl)n2-c1ccc(F)c(C)c1 to increase its LogP value.,Cc1cnc2c(c1)nc(CCCl)n2-c1ccc(F)c(C)c1,3.957740000000003
+18627,Modify the molecule Cc1ccc(CNC(=O)[C@H](C)C2CCN(C(=O)[C@H]3C=c4cc(Cl)ccc4=[NH+]3)CC2)cc1 to have a lower LogP value.,Cc1ccc(CNC(=O)[C@H](C)C2CCN(C(=O)[C@H]3C=c4cc(Cl)ccc4=[NH+]3)CC2)cc1,0.7024200000000018
+61847,Please optimize the molecule Cc1cncc(C(=O)N2CCCc3cc(C)ccc32)c1 to have a lower LogP value.,Cc1cncc(C(=O)N2CCCc3cc(C)ccc32)c1,3.2914400000000024
+109803,Please modify the molecule COc1cccc(NC2CCN(C(=O)c3cccc([N+](=O)[O-])c3)CC2)c1 to increase its LogP value.,COc1cccc(NC2CCN(C(=O)c3cccc([N+](=O)[O-])c3)CC2)c1,3.320100000000002
+46484,Modify the molecule Cc1c(C(=O)NCc2cc(C#N)ccc2F)oc2ccc(Cl)cc12 to increase its LogP value.,Cc1c(C(=O)NCc2cc(C#N)ccc2F)oc2ccc(Cl)cc12,4.335400000000002
+240825,Optimize the molecule C[NH2+][C@@H](CC(C)C)[C@@H]1CCc2cccnc21 to have a lower LogP value.,C[NH2+][C@@H](CC(C)C)[C@@H]1CCc2cccnc21,1.7192999999999994
+200614,Modify the molecule CCCCN(C)C(=O)C1CC[NH+](C2CCC(C)CC2)CC1 to decrease its LogP value.,CCCCN(C)C(=O)C1CC[NH+](C2CCC(C)CC2)CC1,2.1185
+53268,Modify the molecule Nc1cc(C(=O)OCCF)ccc1Cl to decrease its LogP value.,Nc1cc(C(=O)OCCF)ccc1Cl,2.0484999999999998
+143741,Please modify the molecule Cc1cc([C@@H](O)[C@]2(C[NH3+])CCc3ccccc3C2)c(C)s1 to increase its LogP value.,Cc1cc([C@@H](O)[C@]2(C[NH3+])CCc3ccccc3C2)c(C)s1,2.8155400000000013
+229294,Optimize the molecule C[C@@H](NC(=O)c1ccccc1Cn1cccn1)c1cccc(C(F)(F)F)c1 to have a lower LogP value.,C[C@@H](NC(=O)c1ccccc1Cn1cccn1)c1cccc(C(F)(F)F)c1,4.441200000000004
+99671,Please modify the molecule CCOC(=O)N1CCC2(CC1)NC(=O)N(C1CC[NH+](Cc3cccc(F)c3)CC1)C2=O to decrease its LogP value.,CCOC(=O)N1CCC2(CC1)NC(=O)N(C1CC[NH+](Cc3cccc(F)c3)CC1)C2=O,0.9159000000000013
+180774,Please modify the molecule COC(=O)c1cc(CNC(=O)C[C@H](C)c2ccccc2)oc1C to decrease its LogP value.,COC(=O)c1cc(CNC(=O)C[C@H](C)c2ccccc2)oc1C,3.1846200000000016
+221959,Modify the molecule Cc1ccc(CNC(=O)[C@@H]2CCCN(c3nc4ccccc4[nH]c3=O)C2)o1 to have a higher LogP value.,Cc1ccc(CNC(=O)[C@@H]2CCCN(c3nc4ccccc4[nH]c3=O)C2)o1,2.3573200000000005
+177204,Please modify the molecule CC(C)C(=O)NC[C@H]1CCCN(C(=O)N[C@H](C)c2ccc(Cl)s2)C1 to increase its LogP value.,CC(C)C(=O)NC[C@H]1CCCN(C(=O)N[C@H](C)c2ccc(Cl)s2)C1,3.6563000000000017
+98860,Modify the molecule Oc1ccc(Cl)cc1CN(CC(F)F)C1CC1 to have a lower LogP value.,Oc1ccc(Cl)cc1CN(CC(F)F)C1CC1,3.275100000000002
+147728,Please optimize the molecule O=S(=O)(c1ccc(F)cc1)N1CCCN(Cc2cc(-c3ccco3)on2)CC1 to have a higher LogP value.,O=S(=O)(c1ccc(F)cc1)N1CCCN(Cc2cc(-c3ccco3)on2)CC1,2.9703000000000017
+148589,Modify the molecule C=CC[C@@H]1C(C)=NN(C(=O)c2ccc(C)cc2)[C@]1(C)O to have a lower LogP value.,C=CC[C@@H]1C(C)=NN(C(=O)c2ccc(C)cc2)[C@]1(C)O,2.7275200000000015
+55283,Modify the molecule Cc1ccc(C2=NCC(=O)N(CC(=O)N3CCCCC3)c3sc4c(c32)CCC4)cc1 to increase its LogP value.,Cc1ccc(C2=NCC(=O)N(CC(=O)N3CCCCC3)c3sc4c(c32)CCC4)cc1,3.7417200000000026
+188681,Modify the molecule CC(C)[C@H](NC(=O)[C@@H](C)Oc1ccccc1Cl)c1ccccn1 to decrease its LogP value.,CC(C)[C@H](NC(=O)[C@@H](C)Oc1ccccc1Cl)c1ccccn1,4.015800000000002
+216803,Please optimize the molecule Cc1ccc(C(=O)N2CCN(c3ccc(NC(=O)CSc4nnc(C)o4)cc3)CC2)cc1 to have a higher LogP value.,Cc1ccc(C(=O)N2CCN(c3ccc(NC(=O)CSc4nnc(C)o4)cc3)CC2)cc1,3.379640000000002
+141670,Modify the molecule O=C(/C(=C\C=C\c1ccccc1)c1nc2ccccc2o1)c1cccnc1 to increase its LogP value.,O=C(/C(=C\C=C\c1ccccc1)c1nc2ccccc2o1)c1cccnc1,5.202500000000004
+241873,Optimize the molecule COc1ccc([C@@H]2[C@@H](C(=O)Nc3ccc4[nH]ccc4c3)c3ccccc3C(=O)N2C)cc1 to have a higher LogP value.,COc1ccc([C@@H]2[C@@H](C(=O)Nc3ccc4[nH]ccc4c3)c3ccccc3C(=O)N2C)cc1,4.7257000000000025
+120174,Modify the molecule COc1ccccc1OCC(=O)Nc1ccc(Br)c(Cl)c1 to have a higher LogP value.,COc1ccccc1OCC(=O)Nc1ccc(Br)c(Cl)c1,4.128600000000003
+164241,Please modify the molecule C[C@@H](NC(=O)C(C)(C)C)C(=O)N1CCC(C(=O)N(C)C)CC1 to decrease its LogP value.,C[C@@H](NC(=O)C(C)(C)C)C(=O)N1CCC(C(=O)N(C)C)CC1,0.8640000000000008
+83956,Please modify the molecule COc1ccc([C@@H]2c3c(oc4ccccc4c3=O)C(=O)N2c2cc(C)on2)cc1OC to decrease its LogP value.,COc1ccc([C@@H]2c3c(oc4ccccc4c3=O)C(=O)N2c2cc(C)on2)cc1OC,3.8564200000000026
+152649,Modify the molecule Brc1ccc(-c2nnc(COc3ccccc3Br)o2)cc1 to have a lower LogP value.,Brc1ccc(-c2nnc(COc3ccccc3Br)o2)cc1,4.840600000000002
+191770,Modify the molecule COCC(=O)Nc1cccc(C(=O)Nc2cccc(OC)c2)c1 to decrease its LogP value.,COCC(=O)Nc1cccc(C(=O)Nc2cccc(OC)c2)c1,2.532400000000001
+139280,Please optimize the molecule COc1ccc([C@@H](O)[C@H]2CCCN2C(=O)CCc2nc(-c3ccsc3)no2)cc1 to have a lower LogP value.,COc1ccc([C@@H](O)[C@H]2CCCN2C(=O)CCc2nc(-c3ccsc3)no2)cc1,3.4639000000000024
+8009,Modify the molecule COc1ccc(Br)cc1-c1nnc2n(Cc3ccccc3)c3c(=O)n(C)c(=O)n(C)c3n12 to decrease its LogP value.,COc1ccc(Br)cc1-c1nnc2n(Cc3ccccc3)c3c(=O)n(C)c(=O)n(C)c3n12,2.5678
+248709,Modify the molecule C[NH2+][C@H](Cc1ccccn1)c1cc(C(F)(F)F)ccc1F to increase its LogP value.,C[NH2+][C@H](Cc1ccccn1)c1cc(C(F)(F)F)ccc1F,2.716500000000001
+21632,Modify the molecule O=C(Nc1ccc(F)c(F)c1F)c1cc2c(s1)CCC2 to increase its LogP value.,O=C(Nc1ccc(F)c(F)c1F)c1cc2c(s1)CCC2,3.9064000000000014
+171809,Modify the molecule Cc1cc(C)cc(NC(=O)CS[C@@H](C)[C@H](C)O)c1 to increase its LogP value.,Cc1cc(C)cc(NC(=O)CS[C@@H](C)[C@H](C)O)c1,2.744440000000001
+201965,Please modify the molecule C=C(C)CN(CC)C(=O)[C@H](C)[n+]1ccc(Cc2ccccc2)cc1 to increase its LogP value.,C=C(C)CN(CC)C(=O)[C@H](C)[n+]1ccc(Cc2ccccc2)cc1,3.550500000000002
+165417,Optimize the molecule Cc1ccc(C)c(OC2CCN(C[C@H](O)CN3CCOCC3)CC2)c1 to have a higher LogP value.,Cc1ccc(C)c(OC2CCN(C[C@H](O)CN3CCOCC3)CC2)c1,1.83974
+245940,Please optimize the molecule CCCCC[C@H](C)[NH2+][C@H]1CC[C@H]([NH+](C)C)C1 to have a lower LogP value.,CCCCC[C@H](C)[NH2+][C@H]1CC[C@H]([NH+](C)C)C1,0.5842000000000027
+61199,Please optimize the molecule C[C@@H](NC(=O)c1cnc([C@@H]2CCCO2)s1)c1ccc(-n2ccnc2)cc1 to have a lower LogP value.,C[C@@H](NC(=O)c1cnc([C@@H]2CCCO2)s1)c1ccc(-n2ccnc2)cc1,3.671300000000003
+114102,Optimize the molecule CC[C@@H]([NH2+][C@@H](COC)c1ccc(F)c(F)c1)c1cnn(C)c1 to have a lower LogP value.,CC[C@@H]([NH2+][C@@H](COC)c1ccc(F)c(F)c1)c1cnn(C)c1,2.1005
+93592,Modify the molecule CCOC(=O)c1c(NC(=O)c2cc3cccc(OC)c3oc2=O)sc(C)c1C to decrease its LogP value.,CCOC(=O)c1c(NC(=O)c2cc3cccc(OC)c3oc2=O)sc(C)c1C,3.908940000000003
+217129,Optimize the molecule CCCCc1ccc(CC(=O)NC2(C(N)=O)CCCCC2)cc1 to have a higher LogP value.,CCCCc1ccc(CC(=O)NC2(C(N)=O)CCCCC2)cc1,2.876100000000001
+11171,Modify the molecule Cc1ccccc1C(=O)NCCNC(=O)c1nc(Cn2nc(C)c(Cl)c2C)no1 to increase its LogP value.,Cc1ccccc1C(=O)NCCNC(=O)c1nc(Cn2nc(C)c(Cl)c2C)no1,2.05286
+144843,Please optimize the molecule COc1cc(OC)c(C(=O)N(C)CCC(C)C)cc1OC to have a higher LogP value.,COc1cc(OC)c(C(=O)N(C)CCC(C)C)cc1OC,2.8305000000000007
+148864,Modify the molecule CN(CC[NH+]1CCCC1)[C@@H](C(=O)Nc1ccccc1)c1ccccc1 to have a higher LogP value.,CN(CC[NH+]1CCCC1)[C@@H](C(=O)Nc1ccccc1)c1ccccc1,1.9769000000000003
+201642,Modify the molecule O=C(Nc1nc2c(s1)CCCC2)c1cc(F)ccc1Br to decrease its LogP value.,O=C(Nc1nc2c(s1)CCCC2)c1cc(F)ccc1Br,4.175800000000002
+167339,Please modify the molecule Cc1cccnc1NC(=O)c1ccc(/C=C2\SC(=O)NC2=O)cc1 to increase its LogP value.,Cc1cccnc1NC(=O)c1ccc(/C=C2\SC(=O)NC2=O)cc1,2.9662200000000007
+183421,Please optimize the molecule C[C@H](NC(=O)N1CC[C@@H](Nc2ccccc2)C1)c1ccc2c(c1)OCCO2 to have a lower LogP value.,C[C@H](NC(=O)N1CC[C@@H](Nc2ccccc2)C1)c1ccc2c(c1)OCCO2,3.4148000000000023
+184014,Please modify the molecule CC(C)[C@H](C)N1C[C@H]2CCCC[NH+]2C[C@@H]1C to decrease its LogP value.,CC(C)[C@H](C)N1C[C@H]2CCCC[NH+]2C[C@@H]1C,1.1724000000000003
+166818,Please modify the molecule N#Cc1ccsc1NC(=O)CCCOc1ccc(Cl)cc1Cl to decrease its LogP value.,N#Cc1ccsc1NC(=O)CCCOc1ccc(Cl)cc1Cl,4.724280000000002
+162806,Modify the molecule O=C(NC[C@H]1Cc2cccc(F)c2O1)c1c(F)cccc1F to have a higher LogP value.,O=C(NC[C@H]1Cc2cccc(F)c2O1)c1c(F)cccc1F,2.8374000000000006
+102114,Optimize the molecule Cc1noc(C)c1C(=O)N1CCC2(CCC(=O)N(CCCn3cc[nH+]c3)C2)CC1 to have a higher LogP value.,Cc1noc(C)c1C(=O)N1CCC2(CCC(=O)N(CCCn3cc[nH+]c3)C2)CC1,1.8421399999999999
+116490,Modify the molecule COC(C)(C)CNC(=O)N[C@@H]1CCO[C@H]1c1ccc(Cl)c(F)c1 to have a lower LogP value.,COC(C)(C)CNC(=O)N[C@@H]1CCO[C@H]1c1ccc(Cl)c(F)c1,3.0333000000000014
+183034,Please optimize the molecule COc1cc(OC)cc([C@H]2CCN(C(=O)c3c(F)cccc3Cl)C2)c1 to have a lower LogP value.,COc1cc(OC)cc([C@H]2CCN(C(=O)c3c(F)cccc3Cl)C2)c1,4.126000000000004
+177160,Modify the molecule Cc1n[nH]c(-c2ccc(NC(=O)c3cnn(-c4ccc(F)cc4)n3)cc2)n1 to decrease its LogP value.,Cc1n[nH]c(-c2ccc(NC(=O)c3cnn(-c4ccc(F)cc4)n3)cc2)n1,2.7522200000000003
+170125,Modify the molecule Cc1ncsc1CN(C)[C@H](C[NH3+])CC(=O)N(C)C to have a lower LogP value.,Cc1ncsc1CN(C)[C@H](C[NH3+])CC(=O)N(C)C,-0.027879999999998573
+218560,Please modify the molecule COc1cccc(CN(C[C@H]2CC(c3ccccc3)=NO2)C(=O)NC(C)C)c1 to increase its LogP value.,COc1cccc(CN(C[C@H]2CC(c3ccccc3)=NO2)C(=O)NC(C)C)c1,3.8084000000000024
+99209,Modify the molecule O=C(NCCCn1nc2n(c1=O)CCCC2)Nc1ccc(N2CCCS2(=O)=O)cc1 to have a higher LogP value.,O=C(NCCCn1nc2n(c1=O)CCCC2)Nc1ccc(N2CCCS2(=O)=O)cc1,1.1327999999999991
+101718,Please optimize the molecule Cc1cc(C)n(-c2ccc(NC(=O)[C@@H]3CCCCN3C(=O)C(=O)c3ccccc3)cc2)n1 to have a lower LogP value.,Cc1cc(C)n(-c2ccc(NC(=O)[C@@H]3CCCCN3C(=O)C(=O)c3ccccc3)cc2)n1,3.691640000000003
+47778,Optimize the molecule COc1cc(C)ccc1NC(=O)[C@@H]1CC(=O)N(C(C)C)C1 to have a lower LogP value.,COc1cc(C)ccc1NC(=O)[C@@H]1CC(=O)N(C(C)C)C1,2.19902
+88301,Please optimize the molecule c1ccc2c(c1)CCSC[C@@H]2[NH2+]C[C@@H]1C[NH+]2CCN1CC2 to have a higher LogP value.,c1ccc2c(c1)CCSC[C@@H]2[NH2+]C[C@@H]1C[NH+]2CCN1CC2,-0.8368999999999964
+30150,Please optimize the molecule CCC(=O)N[C@@H]1CCC[NH+](CCc2ccc(OC(F)(F)F)cc2)C1 to have a lower LogP value.,CCC(=O)N[C@@H]1CCC[NH+](CCc2ccc(OC(F)(F)F)cc2)C1,1.7011999999999996
+113565,Please modify the molecule C[C@@H]1C[C@@H](C(N)=O)c2ccccc2N1S(=O)(=O)c1ccccc1 to decrease its LogP value.,C[C@@H]1C[C@@H](C(N)=O)c2ccccc2N1S(=O)(=O)c1ccccc1,2.2430000000000003
+215145,Modify the molecule CCOc1ccc2[nH]c(=O)c([C@H](c3nnnn3C(C)(C)C)N3CCc4ccccc4C3)cc2c1 to have a higher LogP value.,CCOc1ccc2[nH]c(=O)c([C@H](c3nnnn3C(C)(C)C)N3CCc4ccccc4C3)cc2c1,3.8160000000000025
+136433,Optimize the molecule C=CCNC(=O)CSc1nnc2cc(C)c3ccc(OC)cc3n12 to have a lower LogP value.,C=CCNC(=O)CSc1nnc2cc(C)c3ccc(OC)cc3n12,2.593820000000001
+242928,Modify the molecule Cc1[nH]c2ccc(C(=O)N[C@@H]3CC[C@H]([NH+](C)C)C3)cc2c1C to increase its LogP value.,Cc1[nH]c2ccc(C(=O)N[C@@H]3CC[C@H]([NH+](C)C)C3)cc2c1C,1.5801399999999999
+196182,Modify the molecule C[C@H](NC(=O)C1CCN(S(C)(=O)=O)CC1)c1cccc(Cl)c1 to decrease its LogP value.,C[C@H](NC(=O)C1CCN(S(C)(=O)=O)CC1)c1cccc(Cl)c1,2.1887999999999996
+164899,Modify the molecule Cc1cc2cc(CNC(=O)c3ccc(S(=O)(=O)N4CCCC4)cc3)ccc2[nH]1 to have a lower LogP value.,Cc1cc2cc(CNC(=O)c3ccc(S(=O)(=O)N4CCCC4)cc3)ccc2[nH]1,3.1908200000000013
+212830,Optimize the molecule Cn1cc(C[C@@H](C[NH3+])c2cccc(F)c2)cn1 to have a lower LogP value.,Cn1cc(C[C@@H](C[NH3+])c2cccc(F)c2)cn1,1.1274000000000002
+120822,Modify the molecule CC(C)(Oc1ccc(Cl)cc1)C(=O)N1CCN(C2CC2)C[C@@H]1Cc1ccccc1 to have a higher LogP value.,CC(C)(Oc1ccc(Cl)cc1)C(=O)N1CCN(C2CC2)C[C@@H]1Cc1ccccc1,4.415300000000004
+127498,Please modify the molecule CC[C@H](Cc1ccc(C)cc1)NC(=O)NNC(=O)c1cc(C)oc1C to decrease its LogP value.,CC[C@H](Cc1ccc(C)cc1)NC(=O)NNC(=O)c1cc(C)oc1C,3.170160000000002
+18043,Modify the molecule Cc1cc(NC(=O)c2cc3c([nH]c2=O)CCCC3)ccc1C(N)=O to have a higher LogP value.,Cc1cc(NC(=O)c2cc3c([nH]c2=O)CCCC3)ccc1C(N)=O,1.91332
+208972,Modify the molecule O=C(Nc1ccc(Br)cc1F)[C@H]1C[C@H]2CC[C@@H]1O2 to increase its LogP value.,O=C(Nc1ccc(Br)cc1F)[C@H]1C[C@H]2CC[C@@H]1O2,3.0942000000000016
+1523,Please modify the molecule CC(C)(C)c1nc(CNC(=O)N[C@H]2CCCC2(C)C)no1 to increase its LogP value.,CC(C)(C)c1nc(CNC(=O)N[C@H]2CCCC2(C)C)no1,2.745000000000001
+148464,Please optimize the molecule COc1cc(-c2noc(-c3cnn(-c4ccccc4)c3)n2)ccn1 to have a higher LogP value.,COc1cc(-c2noc(-c3cnn(-c4ccccc4)c3)n2)ccn1,2.9929000000000006
+114876,Modify the molecule CC[C@H](C)[NH+]1CCN(c2nc(Br)cn3ccnc23)CC1 to increase its LogP value.,CC[C@H](C)[NH+]1CCN(c2nc(Br)cn3ccnc23)CC1,0.9951999999999996
+159090,Optimize the molecule O=C(CNc1ccc(C(F)(F)F)cn1)N1CCCC1 to have a lower LogP value.,O=C(CNc1ccc(C(F)(F)F)cn1)N1CCCC1,2.1346999999999996
+131805,Modify the molecule C[NH+](C)[C@@H]1CC[C@H](NC(=O)c2ccc(OCC(N)=O)cc2)C1 to decrease its LogP value.,C[NH+](C)[C@@H]1CC[C@H](NC(=O)c2ccc(OCC(N)=O)cc2)C1,-0.6538999999999966
+238682,Please modify the molecule CC(=O)N1CCN(Cc2cccc(NC(=O)c3ccc(C)c(C)c3)n2)CC1 to increase its LogP value.,CC(=O)N1CCN(Cc2cccc(NC(=O)c3ccc(C)c(C)c3)n2)CC1,2.614840000000001
+134670,Please optimize the molecule COc1ccc([C@H]2CC(c3ccccc3)=NN2C(=O)Cn2cnc3ccccc32)cc1 to have a higher LogP value.,COc1ccc([C@H]2CC(c3ccccc3)=NN2C(=O)Cn2cnc3ccccc32)cc1,4.422800000000004
+1379,Please optimize the molecule C=C(Br)CN1CCN(c2cc(C)[nH+]c(C)n2)CC1 to have a lower LogP value.,C=C(Br)CN1CCN(c2cc(C)[nH+]c(C)n2)CC1,1.54314
+78205,Modify the molecule Cc1ccc(CCC(=O)N[C@@H]2CCCC[C@H]2C)o1 to decrease its LogP value.,Cc1ccc(CCC(=O)N[C@@H]2CCCC[C@H]2C)o1,3.2155200000000015
+23830,Modify the molecule COc1ccc(OC)c(S(=O)(=O)NCC#CCOc2ccc(C)nc2)c1 to increase its LogP value.,COc1ccc(OC)c(S(=O)(=O)NCC#CCOc2ccc(C)nc2)c1,1.76792
+161689,Please modify the molecule Cc1noc(C)c1CC(=O)Nc1ccc2c(C)n[nH]c2c1 to decrease its LogP value.,Cc1noc(C)c1CC(=O)Nc1ccc2c(C)n[nH]c2c1,2.6573600000000006
+170277,Modify the molecule O=C(CCS(=O)(=O)c1ccccc1)NCC#CCOc1ccccc1F to decrease its LogP value.,O=C(CCS(=O)(=O)c1ccccc1)NCC#CCOc1ccccc1F,2.1881000000000004
+103967,Please optimize the molecule O=c1c(NCc2ccccc2Cl)c(-c2ccccc2)c1=O to have a higher LogP value.,O=c1c(NCc2ccccc2Cl)c(-c2ccccc2)c1=O,3.2151000000000014
+235714,Modify the molecule CC(C)[C@@H](C[NH3+])[C@H](O)CC12CC3CC(CC(C3)C1)C2 to have a higher LogP value.,CC(C)[C@@H](C[NH3+])[C@H](O)CC12CC3CC(CC(C3)C1)C2,2.4679
+210324,Modify the molecule CC(=O)N(c1cccc(Cl)c1)c1nc(CN2CCC[C@H]2[C@@H]2CCC[NH+]2C)cs1 to have a higher LogP value.,CC(=O)N(c1cccc(Cl)c1)c1nc(CN2CCC[C@H]2[C@@H]2CCC[NH+]2C)cs1,3.1226000000000003
+164896,Modify the molecule O=C(C[C@H]1S/C(=N/c2cccc3ccccc23)NC1=O)Nc1cccc(C(F)(F)F)c1 to have a higher LogP value.,O=C(C[C@H]1S/C(=N/c2cccc3ccccc23)NC1=O)Nc1cccc(C(F)(F)F)c1,5.106500000000002
+176125,Modify the molecule CCCOc1ccc2cc(C(=O)Nc3ccc(C)c(C)c3)c(=O)oc2c1 to increase its LogP value.,CCCOc1ccc2cc(C(=O)Nc3ccc(C)c(C)c3)c(=O)oc2c1,4.450940000000004
+241298,Please optimize the molecule CC1(C)CC[C@@H]([NH+]2CCC(C[NH+]3CCCC3)CC2)[C@@H]1[NH3+] to have a higher LogP value.,CC1(C)CC[C@@H]([NH+]2CCC(C[NH+]3CCCC3)CC2)[C@@H]1[NH3+],-1.240899999999994
+459,Please optimize the molecule Cc1ccc(-c2cnc(CCC(=O)NCC(C)(C)c3ccncc3)o2)cc1 to have a lower LogP value.,Cc1ccc(-c2cnc(CCC(=O)NCC(C)(C)c3ccncc3)o2)cc1,4.071620000000003
+47196,Modify the molecule Cc1ccc(C(=O)Nc2cc(Cl)c3nc(NN)sc3c2Cl)cc1 to have a lower LogP value.,Cc1ccc(C(=O)Nc2cc(Cl)c3nc(NN)sc3c2Cl)cc1,4.449420000000002
+35193,Optimize the molecule Cc1ccc(NNC(=O)NC[C@@H]2CCCN(c3ncccn3)C2)nc1 to have a higher LogP value.,Cc1ccc(NNC(=O)NC[C@@H]2CCCN(c3ncccn3)C2)nc1,1.7227199999999996
+7555,Optimize the molecule C[NH2+][C@H]1CC[C@@H](N2CCC([NH+](C)C)CC2)C1 to have a higher LogP value.,C[NH2+][C@H]1CC[C@@H](N2CCC([NH+](C)C)CC2)C1,-1.290399999999996
+1623,Please modify the molecule O=C(Nc1ccc2c(c1)OCCO2)c1cc2cc([N+](=O)[O-])ccc2s1 to decrease its LogP value.,O=C(Nc1ccc2c(c1)OCCO2)c1cc2cc([N+](=O)[O-])ccc2s1,3.833000000000002
+220916,Please optimize the molecule N#CCOc1cccc(CC(=O)N2CC[C@@H](O)C2)c1 to have a higher LogP value.,N#CCOc1cccc(CC(=O)N2CC[C@@H](O)C2)c1,0.7246800000000002
+233282,Please modify the molecule COCCOc1cc(C)ccc1NC(=O)C(=O)N[C@H]1CCC[C@@H](C)[C@@H]1C to increase its LogP value.,COCCOc1cc(C)ccc1NC(=O)C(=O)N[C@H]1CCC[C@@H](C)[C@@H]1C,2.8996200000000005
+210430,Modify the molecule Cc1cccnc1C[C@H](Cl)c1cc(F)ccc1F to increase its LogP value.,Cc1cccnc1C[C@H](Cl)c1cc(F)ccc1F,4.190820000000003
+241441,Modify the molecule CC(C)[NH+](C)C[C@H]1CN(C(=O)c2ccccc2)C[C@@H]1c1cccc(F)c1 to increase its LogP value.,CC(C)[NH+](C)C[C@H]1CN(C(=O)c2ccccc2)C[C@@H]1c1cccc(F)c1,2.6046000000000014
+136905,Optimize the molecule CC[C@H]1c2ccsc2CCN1C(=O)CNc1c(F)cccc1F to have a lower LogP value.,CC[C@H]1c2ccsc2CCN1C(=O)CNc1c(F)cccc1F,3.9742000000000033
+41679,Modify the molecule O=Cc1ccc(OCCC(=O)N[C@H]2CCc3cc(Cl)ccc32)cc1 to have a higher LogP value.,O=Cc1ccc(OCCC(=O)N[C@H]2CCc3cc(Cl)ccc32)cc1,3.725100000000002
+231391,Modify the molecule COc1cccc(NC(=O)NCCN2CCN(c3ccc(C)cc3)CC2)c1C to increase its LogP value.,COc1cccc(NC(=O)NCCN2CCN(c3ccc(C)cc3)CC2)c1C,3.255740000000002
+183577,Modify the molecule c1ccc(Cc2noc(CCc3cnccn3)n2)cc1 to decrease its LogP value.,c1ccc(Cc2noc(CCc3cnccn3)n2)cc1,2.2356
+93210,Modify the molecule CCn1nc(C)c([N+](=O)[O-])c1NCc1c(C)noc1C to have a higher LogP value.,CCn1nc(C)c([N+](=O)[O-])c1NCc1c(C)noc1C,2.3365600000000004
+226437,Modify the molecule COc1ccc2c(c1)CCC[C@@H]2CC(=O)N1CCNC(=O)CC1 to have a lower LogP value.,COc1ccc2c(c1)CCC[C@@H]2CC(=O)N1CCNC(=O)CC1,1.8536999999999997
+23864,Please modify the molecule CCNS(=O)(=O)[C@H]1CCN(C(=O)/C=C/c2cccc(OC)c2)C1 to decrease its LogP value.,CCNS(=O)(=O)[C@H]1CCN(C(=O)/C=C/c2cccc(OC)c2)C1,1.2485999999999993
+63489,Modify the molecule CCc1cccc(NC(=O)[C@H](C)Sc2nnc(-n3nc(C)cc3C)n2N)c1 to decrease its LogP value.,CCc1cccc(NC(=O)[C@H](C)Sc2nnc(-n3nc(C)cc3C)n2N)c1,2.47614
+139627,Modify the molecule Cc1nc(C(C)(C)c2ccccc2)sc1C(=O)NCc1ncoc1C to decrease its LogP value.,Cc1nc(C(C)(C)c2ccccc2)sc1C(=O)NCc1ncoc1C,4.003840000000003
+215144,Modify the molecule Cc1ccc(NC(=O)CN2C(=O)S/C(=C/c3c(C)n(C)c4ccccc34)C2=O)cc1 to have a lower LogP value.,Cc1ccc(NC(=O)CN2C(=O)S/C(=C/c3c(C)n(C)c4ccccc34)C2=O)cc1,4.470140000000003
+186986,Optimize the molecule Cc1cc(C[NH+]2CCC3(CC2)C[C@@H]3c2nnc(-c3ccccc3)o2)on1 to have a lower LogP value.,Cc1cc(C[NH+]2CCC3(CC2)C[C@@H]3c2nnc(-c3ccccc3)o2)on1,2.3856200000000003
+18692,Modify the molecule Cc1ccccc1N1CCN(Cc2cc(=O)n3ccsc3[nH+]2)CC1 to increase its LogP value.,Cc1ccccc1N1CCN(Cc2cc(=O)n3ccsc3[nH+]2)CC1,1.80572
+154105,Optimize the molecule CC(C)([C@H](N)c1ccccc1Cl)[NH+]1CCCCCC1 to have a lower LogP value.,CC(C)([C@H](N)c1ccccc1Cl)[NH+]1CCCCCC1,2.577300000000001
+113378,Modify the molecule Cc1ccccc1[C@@H]1CCCN1CN1C(=O)C[C@]2(CCSC2)C1=O to increase its LogP value.,Cc1ccccc1[C@@H]1CCCN1CN1C(=O)C[C@]2(CCSC2)C1=O,2.9716200000000015
+176603,Please optimize the molecule O=C(NC1CCCC1)[C@H]1CCCN(C(=O)c2ccc(NS(=O)(=O)c3ccc(F)cc3)cc2)C1 to have a higher LogP value.,O=C(NC1CCCC1)[C@H]1CCCN(C(=O)c2ccc(NS(=O)(=O)c3ccc(F)cc3)cc2)C1,3.5375000000000014
+40877,Please optimize the molecule C[C@@H](CCc1ccccc1)NC(=O)C(=O)NCc1ccccc1Cl to have a higher LogP value.,C[C@@H](CCc1ccccc1)NC(=O)C(=O)NCc1ccccc1Cl,3.093700000000001
+164010,Modify the molecule CC(C)c1ccc(N/N=C2/C(=O)NC(=O)N=C2[O-])cc1 to decrease its LogP value.,CC(C)c1ccc(N/N=C2/C(=O)NC(=O)N=C2[O-])cc1,0.5864999999999999
+223763,Modify the molecule Cc1cccc([C@@H](C)[NH2+]C[C@@]2(O)CCOC2)c1 to decrease its LogP value.,Cc1cccc([C@@H](C)[NH2+]C[C@@]2(O)CCOC2)c1,0.7708199999999998
+155254,Please optimize the molecule CCn1ncc(NC(=O)[C@H](C)n2cc3c(n2)c(C)nn3C)c1C to have a lower LogP value.,CCn1ncc(NC(=O)[C@H](C)n2cc3c(n2)c(C)nn3C)c1C,1.8027399999999998
+15103,Modify the molecule CC[C@H](C)NC(=O)c1c([O-])n(-c2ccc(OC)cc2)c2ncccc2c1=O to have a lower LogP value.,CC[C@H](C)NC(=O)c1c([O-])n(-c2ccc(OC)cc2)c2ncccc2c1=O,1.9961999999999998
+106687,Optimize the molecule CCOC(=O)c1cnn([C@@H]2CCCN(C(=O)C[C@H]3CCCO3)C2)c1 to have a higher LogP value.,CCOC(=O)c1cnn([C@@H]2CCCN(C(=O)C[C@H]3CCCO3)C2)c1,1.7924
+111692,Please optimize the molecule COC1(OC)CCOC[C@H]1O to have a higher LogP value.,COC1(OC)CCOC[C@H]1O,-0.24330000000000024
+64386,Modify the molecule CC(C)[NH2+][C@@]1(CO)CC[C@@H](Sc2ccc(C(C)C)cc2)C1 to have a lower LogP value.,CC(C)[NH2+][C@@]1(CO)CC[C@@H](Sc2ccc(C(C)C)cc2)C1,3.1575000000000015
+58067,Modify the molecule C[C@]1(O)CC[C@H]2[C@@H]3CCC4=C/C(=N/OCC(=O)N[C@@H](CO)C(=O)[O-])CC[C@]4(C)[C@H]3CC[C@@]21C to decrease its LogP value.,C[C@]1(O)CC[C@H]2[C@@H]3CCC4=C/C(=N/OCC(=O)N[C@@H](CO)C(=O)[O-])CC[C@]4(C)[C@H]3CC[C@@]21C,1.2997999999999998
+135763,Optimize the molecule COc1ccc(N2C[C@H](c3nnc(NC(=O)c4ccc(Cl)cc4)o3)CC2=O)cc1 to have a lower LogP value.,COc1ccc(N2C[C@H](c3nnc(NC(=O)c4ccc(Cl)cc4)o3)CC2=O)cc1,3.504400000000002
+217785,Modify the molecule NC1=[NH+]C[C@@]2(CCC[C@H](C3CC3)C2)N1c1ccc(Cl)cc1 to decrease its LogP value.,NC1=[NH+]C[C@@]2(CCC[C@H](C3CC3)C2)N1c1ccc(Cl)cc1,1.8942999999999992
+105444,Optimize the molecule CCOc1ccc(NC(=O)[C@@H]2CC(=O)N(CCc3ccccc3)C2)c(C)c1 to have a lower LogP value.,CCOc1ccc(NC(=O)[C@@H]2CC(=O)N(CCc3ccccc3)C2)c(C)c1,3.423420000000002
+211293,Modify the molecule C[NH+](CC(=O)NC(=O)NCc1ccco1)C[C@@H]1COc2ccccc2O1 to increase its LogP value.,C[NH+](CC(=O)NC(=O)NCc1ccco1)C[C@@H]1COc2ccccc2O1,-0.039899999999998936
+246630,Optimize the molecule OCC[C@H](Nc1ccc2nnc(-c3ccccc3)n2n1)c1cccs1 to have a higher LogP value.,OCC[C@H](Nc1ccc2nnc(-c3ccccc3)n2n1)c1cccs1,3.3884000000000016
+14498,Please modify the molecule C=CCN(Cc1ccc(C#N)cc1)[C@H]1CCN(CC(F)(F)F)C1=O to increase its LogP value.,C=CCN(Cc1ccc(C#N)cc1)[C@H]1CCN(CC(F)(F)F)C1=O,2.709480000000001
+8742,Please modify the molecule C[C@H]1C[NH+]2CCCC[C@@H]2CN1c1ccc(N)cc1Br to increase its LogP value.,C[C@H]1C[NH+]2CCCC[C@@H]2CN1c1ccc(N)cc1Br,1.6771999999999996
+213768,Please modify the molecule Cn1c(N2CCC(NC(=O)Nc3ccccc3)CC2)[nH+]c2ccccc21 to increase its LogP value.,Cn1c(N2CCC(NC(=O)Nc3ccccc3)CC2)[nH+]c2ccccc21,2.7829000000000006
+248982,Modify the molecule O=C(Nc1ccc(I)cc1)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1Cl to increase its LogP value.,O=C(Nc1ccc(I)cc1)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1Cl,4.013300000000002
+196672,Modify the molecule OCC1([NH+]2CCCC2)CC[NH2+]CC1 to decrease its LogP value.,OCC1([NH+]2CCCC2)CC[NH2+]CC1,-2.2465999999999964
+199739,Please optimize the molecule CCN(c1ccccc1)S(=O)(=O)c1ccc(NC2CCN(C(=O)C3CC3)CC2)nc1 to have a lower LogP value.,CCN(c1ccccc1)S(=O)(=O)c1ccc(NC2CCN(C(=O)C3CC3)CC2)nc1,3.109700000000002
+194217,Modify the molecule CCc1nn(C)c2c1[nH]c(=S)n2CCCOC to decrease its LogP value.,CCc1nn(C)c2c1[nH]c(=S)n2CCCOC,2.0312900000000003
+108872,Please optimize the molecule OC[C@@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@H]1O to have a higher LogP value.,OC[C@@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@H]1O,-3.2214000000000005
+226817,Please modify the molecule CCC[NH+]1CCC(NC(=O)NC2(CC(=O)[O-])CCC2)CC1 to increase its LogP value.,CCC[NH+]1CCC(NC(=O)NC2(CC(=O)[O-])CCC2)CC1,-1.194399999999997
+146668,Modify the molecule COc1ccc2c(c1)C=C(C(=O)N1CCc3[nH]ncc3C1)CO2 to decrease its LogP value.,COc1ccc2c(c1)C=C(C(=O)N1CCc3[nH]ncc3C1)CO2,1.779
+42942,Modify the molecule Cc1nc2cc(C(=O)[O-])ccc2n1CCCN1CCOCC1 to have a higher LogP value.,Cc1nc2cc(C(=O)[O-])ccc2n1CCCN1CCOCC1,0.43052
+36015,Modify the molecule CC(=O)c1ccc(NC(=O)c2cccc(NC(=O)N3CCSc4ncccc43)c2)cc1 to have a higher LogP value.,CC(=O)c1ccc(NC(=O)c2cccc(NC(=O)N3CCSc4ncccc43)c2)cc1,4.680700000000003
+11959,Please optimize the molecule Cn1cccc1CNc1cnn(CC(=O)N2CCOCC2)c1 to have a higher LogP value.,Cn1cccc1CNc1cnn(CC(=O)N2CCOCC2)c1,0.6924999999999997
+59294,Modify the molecule CC(C)[C@@H](c1nnnn1Cc1ccc(F)cc1)N1CCN(c2ccccc2F)CC1 to increase its LogP value.,CC(C)[C@@H](c1nnnn1Cc1ccc(F)cc1)N1CCN(c2ccccc2F)CC1,3.518900000000002
+97581,Please optimize the molecule CCN(C(=O)CSc1nnnn1-c1ccccc1C)[C@H]1CCS(=O)(=O)C1 to have a lower LogP value.,CCN(C(=O)CSc1nnnn1-c1ccccc1C)[C@H]1CCS(=O)(=O)C1,1.09842
+209937,Modify the molecule O=C(CSc1ccccc1Br)c1c[nH]c2ccccc12 to have a lower LogP value.,O=C(CSc1ccccc1Br)c1c[nH]c2ccccc12,4.905400000000003
+193497,Modify the molecule Cn1cccc1CN1CCc2c(Br)cccc2C1 to increase its LogP value.,Cn1cccc1CN1CCc2c(Br)cccc2C1,3.345900000000002
+78144,Modify the molecule CCC(CC)C(=O)NNC(=O)c1ccc(Br)s1 to increase its LogP value.,CCC(CC)C(=O)NNC(=O)c1ccc(Br)s1,2.7077999999999998
+186396,Modify the molecule COc1ccc(NC(=O)[C@@H]2[C@@H]3NC(=S)N[C@@]2(C)Oc2ccccc23)cc1 to decrease its LogP value.,COc1ccc(NC(=O)[C@@H]2[C@@H]3NC(=S)N[C@@]2(C)Oc2ccccc23)cc1,2.5775000000000006
+90260,Please modify the molecule COc1ccc(CNC(=O)NC[C@@H](O)c2ccco2)cc1OC to increase its LogP value.,COc1ccc(CNC(=O)NC[C@@H](O)c2ccco2)cc1OC,1.8296000000000001
+68676,Please modify the molecule CCCCN(CC)[C@H](C[NH3+])c1cc(Cl)cs1 to decrease its LogP value.,CCCCN(CC)[C@H](C[NH3+])c1cc(Cl)cs1,2.8064999999999998
+122885,Modify the molecule COC(=O)[C@@H]1CN(C(=O)c2cc(C(C)=O)c[nH]2)C[C@H]1C to have a higher LogP value.,COC(=O)[C@@H]1CN(C(=O)c2cc(C(C)=O)c[nH]2)C[C@H]1C,1.0984
+34501,Please modify the molecule O=C([C@@H]1CC(=O)N(c2ccccc2Cl)C1)N1CCO[C@H](c2ccc(F)cc2)C1 to increase its LogP value.,O=C([C@@H]1CC(=O)N(c2ccccc2Cl)C1)N1CCO[C@H](c2ccc(F)cc2)C1,3.432100000000002
+56665,Optimize the molecule CC[C@H](C)[C@@H](C(=O)Nc1ccn(C)n1)N1C(=O)c2ccccc2C1=O to have a lower LogP value.,CC[C@H](C)[C@@H](C(=O)Nc1ccn(C)n1)N1C(=O)c2ccccc2C1=O,2.0694999999999997
+75651,Modify the molecule CO[C@@H]1CCCN(C(=O)N[C@@H](C)c2nc(C(C)(C)C)no2)C1 to increase its LogP value.,CO[C@@H]1CCCN(C(=O)N[C@@H](C)c2nc(C(C)(C)C)no2)C1,2.2485
+168748,Optimize the molecule CC(C)(C)CC(=O)Nc1ccc(F)cc1F to have a lower LogP value.,CC(C)(C)CC(=O)Nc1ccc(F)cc1F,3.339500000000002
+93983,Optimize the molecule C#CCN1C(=O)c2ccccc2N[C@H]1c1ccc(OC)c(OCC)c1 to have a lower LogP value.,C#CCN1C(=O)c2ccccc2N[C@H]1c1ccc(OC)c(OCC)c1,3.2936000000000023
+175578,Modify the molecule O[C@H](C[C@@H]1CCCCC[NH+]1Cc1c[nH]nc1-c1cccnc1)c1ccccc1 to have a lower LogP value.,O[C@H](C[C@@H]1CCCCC[NH+]1Cc1c[nH]nc1-c1cccnc1)c1ccccc1,2.922900000000001
+40546,Modify the molecule CNc1nc(Cc2ccc(OC)nc2)ns1 to have a lower LogP value.,CNc1nc(Cc2ccc(OC)nc2)ns1,1.5742
+236962,Modify the molecule CCN(Cc1c(F)cccc1Cl)C(=O)CCc1c(C)nn(C)c1C to have a lower LogP value.,CCN(Cc1c(F)cccc1Cl)C(=O)CCc1c(C)nn(C)c1C,3.8107400000000027
+116275,Optimize the molecule COc1ccc(CCn2cc(C(=O)[O-])c(=O)[nH]c2=O)cc1 to have a higher LogP value.,COc1ccc(CCn2cc(C(=O)[O-])c(=O)[nH]c2=O)cc1,-0.8485999999999994
+16835,Optimize the molecule CC[C@H](C)[NH+](CC)CC(=O)N(C)c1ccc(N)cc1 to have a lower LogP value.,CC[C@H](C)[NH+](CC)CC(=O)N(C)c1ccc(N)cc1,0.9349000000000011
+61804,Modify the molecule [NH3+][C@H](c1ncc[nH]1)[C@@H]1CCCc2cccnc21 to decrease its LogP value.,[NH3+][C@H](c1ncc[nH]1)[C@@H]1CCCc2cccnc21,1.2077999999999987
+50516,Optimize the molecule O=C(C[C@@H]1C(=O)Nc2ncnn21)Nc1cccc(F)c1 to have a lower LogP value.,O=C(C[C@@H]1C(=O)Nc2ncnn21)Nc1cccc(F)c1,0.9391999999999995
+141349,Modify the molecule O=C1CC[C@H](C(=O)N[C@H]2CCc3ccccc32)N1 to increase its LogP value.,O=C1CC[C@H](C(=O)N[C@H]2CCc3ccccc32)N1,1.0687000000000002
+227915,Modify the molecule Cc1[nH]c2ccc(C(=O)N[C@H]3CC[C@@H]([NH+](C)C)C3)cc2c1C to have a lower LogP value.,Cc1[nH]c2ccc(C(=O)N[C@H]3CC[C@@H]([NH+](C)C)C3)cc2c1C,1.5801399999999999
+155378,Modify the molecule CCCCCNC(=O)NC1CC[NH+](CC(N)=O)CC1 to increase its LogP value.,CCCCCNC(=O)NC1CC[NH+](CC(N)=O)CC1,-0.9915999999999958
+132107,Modify the molecule O=C(C[NH+]1CC[C@](O)(C(F)(F)F)C1)NCc1ccc(Cl)cc1 to have a lower LogP value.,O=C(C[NH+]1CC[C@](O)(C(F)(F)F)C1)NCc1ccc(Cl)cc1,0.5382
+83051,Optimize the molecule CCn1c(SCC(=O)Nc2ccnn2C2CCCC2)nc2cc(S(N)(=O)=O)ccc21 to have a higher LogP value.,CCn1c(SCC(=O)Nc2ccnn2C2CCCC2)nc2cc(S(N)(=O)=O)ccc21,2.7460000000000004
+184803,Modify the molecule Clc1cc(N2CCC[C@H](OCc3cccnc3)C2)nc2[nH]ccc12 to decrease its LogP value.,Clc1cc(N2CCC[C@H](OCc3cccnc3)C2)nc2[nH]ccc12,3.7969000000000017
+68334,Please optimize the molecule COc1cc(N2CCN(C(=O)OC(C)(C)C)C[C@@H]2C)nc(SC)n1 to have a higher LogP value.,COc1cc(N2CCN(C(=O)OC(C)(C)C)C[C@@H]2C)nc(SC)n1,2.652700000000001
+102388,Modify the molecule C[C@H](CCCO)NC(=O)N(Cc1ccccc1)C1CC1 to have a lower LogP value.,C[C@H](CCCO)NC(=O)N(Cc1ccccc1)C1CC1,2.521600000000001
+2646,Please modify the molecule CN1CCN(C(=O)[C@@]23CC[C@@](C)(c4nc5cc6c(cc5nc42)OCO6)C3(C)C)CC1 to decrease its LogP value.,CN1CCN(C(=O)[C@@]23CC[C@@](C)(c4nc5cc6c(cc5nc42)OCO6)C3(C)C)CC1,2.4616000000000007
+155141,Optimize the molecule C[C@H]1CN(C[C@@H]2CCC[NH+]2CC(=O)NC[C@@H]2CCCO2)C[C@H](C)O1 to have a higher LogP value.,C[C@H]1CN(C[C@@H]2CCC[NH+]2CC(=O)NC[C@@H]2CCCO2)C[C@H](C)O1,-0.5618999999999952
+57338,Modify the molecule CCOC(=O)C1=C(Cc2ccc(OC)cc2)C(=O)c2ccccc2C1=O to have a higher LogP value.,CCOC(=O)C1=C(Cc2ccc(OC)cc2)C(=O)c2ccccc2C1=O,3.1766000000000023
+192257,Modify the molecule O=S(=O)([C@@H]1CCN(Cc2ccc(Cl)c(F)c2)C1)N1CCCC1 to have a higher LogP value.,O=S(=O)([C@@H]1CCN(Cc2ccc(Cl)c(F)c2)C1)N1CCCC1,2.479
+33404,Please modify the molecule CCOC(=O)c1sc(NC(=O)/C=C/c2cnn(C)c2)c(C#N)c1C to decrease its LogP value.,CCOC(=O)c1sc(NC(=O)/C=C/c2cnn(C)c2)c(C#N)c1C,2.4903000000000004
+247981,Optimize the molecule C[C@H](C(N)=O)N1C[C@@H](c2ccc(Cl)cc2)CC1=O to have a higher LogP value.,C[C@H](C(N)=O)N1C[C@@H](c2ccc(Cl)cc2)CC1=O,1.5297000000000003
+54903,Modify the molecule COc1ccnc(NC(=O)c2cc3c([nH]c2=O)CCCC3)c1 to decrease its LogP value.,COc1ccnc(NC(=O)c2cc3c([nH]c2=O)CCCC3)c1,1.9095999999999997
+22644,Optimize the molecule CC(C)(C)N1CCN(C(=O)CCCC(=O)[O-])CC1 to have a lower LogP value.,CC(C)(C)N1CCN(C(=O)CCCC(=O)[O-])CC1,-0.15069999999999872
+159133,Modify the molecule CCC[NH2+][C@H]1CC[C@@H]([NH+]2CCC(C[NH+]3CCCC3)CC2)C1 to have a lower LogP value.,CCC[NH2+][C@H]1CC[C@@H]([NH+]2CCC(C[NH+]3CCCC3)CC2)C1,-1.1454999999999946
+51055,Please optimize the molecule COc1ccc([C@@H](C#N)NC(=O)c2ccc3cc[nH]c3c2)c(OC)c1 to have a lower LogP value.,COc1ccc([C@@H](C#N)NC(=O)c2ccc3cc[nH]c3c2)c(OC)c1,3.179780000000001
+18606,Modify the molecule O=C(NC[C@@H]1CN2CCCC[C@H]2CO1)N1CCC(CN2CCOCC2)CC1 to increase its LogP value.,O=C(NC[C@@H]1CN2CCCC[C@H]2CO1)N1CCC(CN2CCOCC2)CC1,0.9935000000000007
+87740,Please optimize the molecule O=C(c1n[nH]c([O-])n1)N1CCC[C@H]1C[C@H](O)c1ccccc1 to have a higher LogP value.,O=C(c1n[nH]c([O-])n1)N1CCC[C@H]1C[C@H](O)c1ccccc1,0.6065999999999994
+84409,Modify the molecule COc1cc(Cl)ccc1C(=O)Nc1cnn(C(C)C)c1 to have a higher LogP value.,COc1cc(Cl)ccc1C(=O)Nc1cnn(C(C)C)c1,3.378300000000001
+12319,Modify the molecule C[NH+](C)[C@@H](CNC(=O)c1ccccc1C(F)(F)F)c1ccc(F)cc1 to increase its LogP value.,C[NH+](C)[C@@H](CNC(=O)c1ccccc1C(F)(F)F)c1ccc(F)cc1,2.4601000000000015
+18024,Please optimize the molecule Cc1cccc(S(N)(=O)=O)c1[N+](=O)[O-] to have a higher LogP value.,Cc1cccc(S(N)(=O)=O)c1[N+](=O)[O-],0.5506200000000001
+69670,Optimize the molecule Cc1ccc(-c2cc(C(=O)N(C)Cc3ccnc4ccccc34)[nH]n2)s1 to have a higher LogP value.,Cc1ccc(-c2cc(C(=O)N(C)Cc3ccnc4ccccc34)[nH]n2)s1,4.267020000000003
+159752,Please optimize the molecule CC(C)Oc1cccnc1C(=O)Nc1cccc(Oc2cnccn2)c1 to have a higher LogP value.,CC(C)Oc1cccnc1C(=O)Nc1cccc(Oc2cnccn2)c1,3.703400000000002
+85763,Modify the molecule CC[C@](C)([NH3+])C(=O)N1CC[C@H](COC)C1 to increase its LogP value.,CC[C@](C)([NH3+])C(=O)N1CC[C@H](COC)C1,-0.10809999999999942
+38826,Modify the molecule CCn1c(C)cc(C(=O)N(C)CC(=O)Nc2c(C)cccc2C)c1C to have a higher LogP value.,CCn1c(C)cc(C(=O)N(C)CC(=O)Nc2c(C)cccc2C)c1C,3.4523800000000024
+94406,Optimize the molecule C[NH+](Cc1csc(Br)c1)C[C@H]1CCC(C)(C)[C@H]1O to have a lower LogP value.,C[NH+](Cc1csc(Br)c1)C[C@H]1CCC(C)(C)[C@H]1O,2.3224000000000014
+125440,Modify the molecule Cc1cccc(CN(C)C(=O)[C@@]2(C(F)(F)F)CC[NH2+]C2)n1 to have a lower LogP value.,Cc1cccc(CN(C)C(=O)[C@@]2(C(F)(F)F)CC[NH2+]C2)n1,0.8642200000000001
+116179,Please optimize the molecule Cc1csc(Sc2ccc(NC(=O)c3cccnc3Cl)cc2)n1 to have a higher LogP value.,Cc1csc(Sc2ccc(NC(=O)c3cccnc3Cl)cc2)n1,4.903420000000002
+83040,Modify the molecule O=C(N[C@@H]1c2ccccc2C[C@H]1O)c1cccc(OCC(F)F)n1 to have a higher LogP value.,O=C(N[C@@H]1c2ccccc2C[C@H]1O)c1cccc(OCC(F)F)n1,2.1136
+65865,Please modify the molecule CCOC(=O)Cn1c([C@H](C)Br)nc2ccccc2c1=O to decrease its LogP value.,CCOC(=O)Cn1c([C@H](C)Br)nc2ccccc2c1=O,2.4155000000000006
+241919,Optimize the molecule CC(C)CC(=O)C1=C([O-])C(=O)N(CC[NH3+])[C@H]1c1ccc(F)cc1 to have a higher LogP value.,CC(C)CC(=O)C1=C([O-])C(=O)N(CC[NH3+])[C@H]1c1ccc(F)cc1,0.18050000000000105
+37559,Please optimize the molecule Cc1cc(C[C@@H](C)N[C@@H](C)c2ccncc2)n(-c2ccccc2)n1 to have a higher LogP value.,Cc1cc(C[C@@H](C)N[C@@H](C)c2ccncc2)n(-c2ccccc2)n1,3.8575200000000027
+56679,Optimize the molecule CCn1nc(C)c([C@H](C)[NH2+]C[C@H]2CCCN(c3ncccn3)C2)c1C to have a lower LogP value.,CCn1nc(C)c([C@H](C)[NH2+]C[C@H]2CCCN(c3ncccn3)C2)c1C,1.8508399999999998
+62574,Modify the molecule COc1cccc(-c2nnc3sc(-c4cc(OC)c(OC)c(OC)c4)nn23)c1 to increase its LogP value.,COc1cccc(-c2nnc3sc(-c4cc(OC)c(OC)c(OC)c4)nn23)c1,3.5542000000000025
+62581,Please optimize the molecule COc1ccc(-c2cc(CNC(=O)c3ccc([N+](=O)[O-])o3)no2)cc1 to have a higher LogP value.,COc1ccc(-c2cc(CNC(=O)c3ccc([N+](=O)[O-])o3)no2)cc1,2.7814000000000005
+137849,Modify the molecule COc1cc(C[C@@H](C)[C@@H](C)[C@H](O)c2ccc(O)c(OC)c2)ccc1O to have a lower LogP value.,COc1cc(C[C@@H](C)[C@@H](C)[C@H](O)c2ccc(O)c(OC)c2)ccc1O,3.6633000000000027
+47081,Optimize the molecule CCN[C@@]1(C(=O)OC)CC[C@H](Sc2n[nH]c(=O)n2C)C1 to have a higher LogP value.,CCN[C@@]1(C(=O)OC)CC[C@H](Sc2n[nH]c(=O)n2C)C1,0.2742999999999994
+175639,Modify the molecule Cn1c(SCCOc2cccc(Br)c2)nnc1[C@H]1CCS(=O)(=O)C1 to have a higher LogP value.,Cn1c(SCCOc2cccc(Br)c2)nnc1[C@H]1CCS(=O)(=O)C1,2.6508000000000003
+141829,Please modify the molecule COCCCOc1nc(C(F)(F)F)ccc1C[NH3+] to decrease its LogP value.,COCCCOc1nc(C(F)(F)F)ccc1C[NH3+],1.2576000000000003
+184948,Please optimize the molecule O=C1CN(C(=O)C[C@H]2CCCCO2)CCN1 to have a higher LogP value.,O=C1CN(C(=O)C[C@H]2CCCCO2)CCN1,-0.09599999999999959
+164219,Modify the molecule CC(C)c1n[nH]c(NC(=O)[C@H]2CCCN(c3ncccn3)C2)n1 to increase its LogP value.,CC(C)c1n[nH]c(NC(=O)[C@H]2CCCN(c3ncccn3)C2)n1,1.5732
+71964,Modify the molecule Cc1ccc(N(Cc2ccco2)C(=O)C2CCN(S(=O)(=O)c3ccc4c(c3)OCCO4)CC2)cc1 to have a lower LogP value.,Cc1ccc(N(Cc2ccco2)C(=O)C2CCN(S(=O)(=O)c3ccc4c(c3)OCCO4)CC2)cc1,3.9933200000000033
+70134,Modify the molecule C[NH+](C)CCO/N=C(/C=C\c1ccc(O)cc1)c1ccccc1F to increase its LogP value.,C[NH+](C)CCO/N=C(/C=C\c1ccc(O)cc1)c1ccccc1F,2.109900000000001
+154524,Please optimize the molecule CN(CCc1cccs1)C(=O)NCC1(c2ccc(F)cc2F)CC1 to have a higher LogP value.,CN(CCc1cccs1)C(=O)NCC1(c2ccc(F)cc2F)CC1,3.942000000000003
+117897,Modify the molecule OCC[NH+](Cc1cccnc1)[C@@H]1CCC[C@H](C2CC2)C1 to decrease its LogP value.,OCC[NH+](Cc1cccnc1)[C@@H]1CCC[C@H](C2CC2)C1,1.4275999999999998
+4158,Modify the molecule COc1ccc(C)cc1N[C@@H](C)C(=O)NC1CCCCC1 to have a higher LogP value.,COc1ccc(C)cc1N[C@@H](C)C(=O)NC1CCCCC1,3.2529200000000023
+92928,Please modify the molecule C[C@H](NC(=O)c1ccc(C(C)(C)C)cc1)C(=O)N(C)C1CCOCC1 to decrease its LogP value.,C[C@H](NC(=O)c1ccc(C(C)(C)C)cc1)C(=O)N(C)C1CCOCC1,2.7398000000000016
+123104,Modify the molecule O=C(CCn1cncn1)N(Cc1ccccc1)Cc1ccco1 to have a higher LogP value.,O=C(CCn1cncn1)N(Cc1ccccc1)Cc1ccco1,2.4902000000000006
+162591,Please modify the molecule CCOC(=O)c1c(/N=C/c2cc(I)ccc2O)sc2c1CC[NH+](C)C2 to increase its LogP value.,CCOC(=O)c1c(/N=C/c2cc(I)ccc2O)sc2c1CC[NH+](C)C2,2.556400000000001
+20717,Optimize the molecule COc1cc(OC)cc(C(=O)N2CCN(c3ccc(N4CCCC4)nn3)CC2)c1 to have a lower LogP value.,COc1cc(OC)cc(C(=O)N2CCN(c3ccc(N4CCCC4)nn3)CC2)c1,2.0564
+64569,Please modify the molecule CCc1ccc(NC(=O)[C@@H](C)Sc2nc(C)c(C)n2CC(C)C)cc1 to increase its LogP value.,CCc1ccc(NC(=O)[C@@H](C)Sc2nc(C)c(C)n2CC(C)C)cc1,4.837640000000004
+180517,Please optimize the molecule COc1ccc(C(=O)N2CCC([C@H](NC(=O)c3ccc(F)cc3)C(=O)N3CCOCC3)CC2)cc1 to have a lower LogP value.,COc1ccc(C(=O)N2CCC([C@H](NC(=O)c3ccc(F)cc3)C(=O)N3CCOCC3)CC2)cc1,2.3439000000000005
+103481,Optimize the molecule C[C@H](Cc1ccc(O)cc1)NC(=O)N[C@H]1CC[C@H]([NH+](C)C)C1 to have a higher LogP value.,C[C@H](Cc1ccc(O)cc1)NC(=O)N[C@H]1CC[C@H]([NH+](C)C)C1,0.6880000000000004
+11070,Please modify the molecule CCc1cc(C[NH+](C)C)c(O)c(C[NH+](C)C)c1 to decrease its LogP value.,CCc1cc(C[NH+](C)C)c(O)c(C[NH+](C)C)c1,-0.7563999999999977
+246409,Optimize the molecule CCOC(=O)c1ccc(NC(=O)c2c(C)cccc2C)c(O)c1 to have a higher LogP value.,CCOC(=O)c1ccc(NC(=O)c2c(C)cccc2C)c(O)c1,3.4380400000000018
+215250,Modify the molecule CCN([C@H](C)c1cc2ccccc2o1)S(=O)(=O)c1ccc(Cl)nc1 to have a lower LogP value.,CCN([C@H](C)c1cc2ccccc2o1)S(=O)(=O)c1ccc(Cl)nc1,4.253000000000004
+157604,Modify the molecule CCC[NH+](C)C[C@@H]1CCN(C(=O)NCc2cc[nH+]c(N3CCCC3)c2)C1 to decrease its LogP value.,CCC[NH+](C)C[C@@H]1CCN(C(=O)NCc2cc[nH+]c(N3CCCC3)c2)C1,0.5571000000000024
+158944,Modify the molecule CC(=O)N1CCCc2cc(S(=O)(=O)N(C)Cc3cccc(Cl)c3)ccc21 to increase its LogP value.,CC(=O)N1CCCc2cc(S(=O)(=O)N(C)Cc3cccc(Cl)c3)ccc21,3.459800000000002
+206775,Optimize the molecule C[NH+]1CCC(N[C@@H]2COc3cc(O)ccc32)CC1 to have a higher LogP value.,C[NH+]1CCC(N[C@@H]2COc3cc(O)ccc32)CC1,0.09240000000000093
+38739,Optimize the molecule Cc1ccc(NC(=O)CN2N=N[C@H]3C(=O)N(c4ccc(Cl)cc4)C(=O)[C@H]32)c(Cl)c1 to have a lower LogP value.,Cc1ccc(NC(=O)CN2N=N[C@H]3C(=O)N(c4ccc(Cl)cc4)C(=O)[C@H]32)c(Cl)c1,3.2337200000000017
+50136,Modify the molecule C[C@H](c1c(F)cccc1F)S(=O)(=O)CCOC1CCCCCC1 to have a lower LogP value.,C[C@H](c1c(F)cccc1F)S(=O)(=O)CCOC1CCCCCC1,4.180000000000004
+195676,Please modify the molecule N#Cc1cc(N2C[C@H]3CC=CC[C@@H]3C2)nc2ccccc12 to decrease its LogP value.,N#Cc1cc(N2C[C@H]3CC=CC[C@@H]3C2)nc2ccccc12,3.508880000000002
+9121,Modify the molecule C[NH2+][C@@]1(CO)CC[C@H](OCC2CCCCC2)C1 to have a lower LogP value.,C[NH2+][C@@]1(CO)CC[C@H](OCC2CCCCC2)C1,1.0600999999999998
+91793,Optimize the molecule COc1cc(NC(=O)c2ccc(-c3ccccc3[N+](=O)[O-])o2)ccc1NC(=O)C(C)C to have a lower LogP value.,COc1cc(NC(=O)c2ccc(-c3ccccc3[N+](=O)[O-])o2)ccc1NC(=O)C(C)C,4.710200000000003
+9449,Modify the molecule CC[C@@H](NC(=O)Cn1c(CS(C)(=O)=O)nc2ccccc21)c1cccc(Cl)c1 to increase its LogP value.,CC[C@@H](NC(=O)Cn1c(CS(C)(=O)=O)nc2ccccc21)c1cccc(Cl)c1,3.501800000000002
+62424,Modify the molecule CC[NH2+]C[C@@H]1CCO[C@@H]1c1cn2ccccc2n1 to increase its LogP value.,CC[NH2+]C[C@@H]1CCO[C@@H]1c1cn2ccccc2n1,0.9951999999999996
+6116,Modify the molecule Cc1cc(=O)c(C(=O)NO[C@@H]2CCCCO2)nn1-c1ccccc1 to decrease its LogP value.,Cc1cc(=O)c(C(=O)NO[C@@H]2CCCCO2)nn1-c1ccccc1,1.7289199999999991
+47283,Optimize the molecule COc1cccc([C@@H]2c3c(nc(N4CCCC[C@@H]4C)[nH]c3=O)NC(=O)[C@@H]2C#N)c1OC to have a higher LogP value.,COc1cccc([C@@H]2c3c(nc(N4CCCC[C@@H]4C)[nH]c3=O)NC(=O)[C@@H]2C#N)c1OC,2.3896799999999994
+54227,Modify the molecule Cc1ccc([C@@H](C)CNC(=O)N(C)Cc2nnc(C)n2C)cc1 to have a higher LogP value.,Cc1ccc([C@@H](C)CNC(=O)N(C)Cc2nnc(C)n2C)cc1,2.37704
+231526,Optimize the molecule CCC[C@@H](C)[NH2+]Cc1coc(-c2ccc(C)cc2)n1 to have a higher LogP value.,CCC[C@@H](C)[NH2+]Cc1coc(-c2ccc(C)cc2)n1,2.902020000000001
+22086,Modify the molecule CCOC(=O)c1sc(N/N=C/[C@H]2CC=CCC2)nc1C to have a higher LogP value.,CCOC(=O)c1sc(N/N=C/[C@H]2CC=CCC2)nc1C,3.382220000000002
+204686,Modify the molecule CCc1c(N)nnn1CCN1CCOCC1 to increase its LogP value.,CCc1c(N)nnn1CCN1CCOCC1,-0.24509999999999899
+189234,Please modify the molecule CCCn1cc(NS(=O)(=O)c2ccc(OC)c(OC)c2)ccc1=O to increase its LogP value.,CCCn1cc(NS(=O)(=O)c2ccc(OC)c(OC)c2)ccc1=O,2.0763
+126089,Please modify the molecule O=S(=O)(c1ccc2ccccc2c1)N1CCCSC[C@@H]1CN1CCOCC1 to increase its LogP value.,O=S(=O)(c1ccc2ccccc2c1)N1CCCSC[C@@H]1CN1CCOCC1,2.6682000000000006
+193842,Modify the molecule COc1c(CN[C@@H](c2ccc(C)cc2)c2cccs2)c(C)nn1C to increase its LogP value.,COc1c(CN[C@@H](c2ccc(C)cc2)c2cccs2)c(C)nn1C,3.986240000000003
+186097,Please modify the molecule CC(C)(CNCC(F)F)S(C)(=O)=O to increase its LogP value.,CC(C)(CNCC(F)F)S(C)(=O)=O,0.6643000000000001
+64285,Please optimize the molecule Cc1cc(C)c2nc3c(cc2c1)CN(Cc1cccnc1)/C(=[NH+]/C[C@@H]1CCCO1)S3 to have a lower LogP value.,Cc1cc(C)c2nc3c(cc2c1)CN(Cc1cccnc1)/C(=[NH+]/C[C@@H]1CCCO1)S3,2.9701400000000007
+13429,Please optimize the molecule COc1ccc(CNC(=O)N[C@H]2CCCC[C@H]2CO)c(OC)c1 to have a higher LogP value.,COc1ccc(CNC(=O)N[C@H]2CCCC[C@H]2CO)c(OC)c1,2.0541
+238257,Please modify the molecule C[C@H](NC(=O)Cc1ccc[nH]1)c1ccc(F)cc1F to increase its LogP value.,C[C@H](NC(=O)Cc1ccc[nH]1)c1ccc(F)cc1F,2.7128000000000005
+127323,Modify the molecule O=C(CC1C[C@@H]2CC[C@H](C1)[NH2+]2)Nc1ccccc1[N+](=O)[O-] to have a higher LogP value.,O=C(CC1C[C@@H]2CC[C@H](C1)[NH2+]2)Nc1ccccc1[N+](=O)[O-],1.4277999999999997
+221259,Modify the molecule CC(C)Cn1c(S[C@@H](C)C(=O)Nc2c(Cl)cc(Cl)cc2Cl)nnc1N1CCOCC1 to decrease its LogP value.,CC(C)Cn1c(S[C@@H](C)C(=O)Nc2c(Cl)cc(Cl)cc2Cl)nnc1N1CCOCC1,4.850200000000004
+46254,Modify the molecule CN(C(=O)c1ccc(-c2ccncc2)[nH]c1=O)c1ccccc1F to decrease its LogP value.,CN(C(=O)c1ccc(-c2ccncc2)[nH]c1=O)c1ccccc1F,2.8526000000000007
+66871,Please modify the molecule C[C@@H]([NH2+]Cc1ccc(-n2cccn2)cc1)c1ccc(N2CCCC2=O)cc1 to decrease its LogP value.,C[C@@H]([NH2+]Cc1ccc(-n2cccn2)cc1)c1ccc(N2CCCC2=O)cc1,2.8237000000000005
+78396,Please optimize the molecule Cc1ccc(CC(=O)Nc2ccc(N3CCO[C@@H](C)C3)cc2)cc1O to have a higher LogP value.,Cc1ccc(CC(=O)Nc2ccc(N3CCO[C@@H](C)C3)cc2)cc1O,3.106920000000002
+8198,Optimize the molecule C[C@H](NC(=O)[C@@H](C)Oc1ccc(Cl)cc1Br)C(=O)[O-] to have a lower LogP value.,C[C@H](NC(=O)[C@@H](C)Oc1ccc(Cl)cc1Br)C(=O)[O-],1.1243999999999998
+199027,Modify the molecule Cc1cc(C)n(NC(=O)[C@H](C)n2nc(C(F)(F)F)c(Cl)c2C)c(=O)c1 to have a higher LogP value.,Cc1cc(C)n(NC(=O)[C@H](C)n2nc(C(F)(F)F)c(Cl)c2C)c(=O)c1,2.973560000000001
+235695,Please optimize the molecule CCOc1ccccc1NC(=O)N[C@@H](C)c1c(-n2cccc2)sc2c1CC[NH+](CC)C2 to have a lower LogP value.,CCOc1ccccc1NC(=O)N[C@@H](C)c1c(-n2cccc2)sc2c1CC[NH+](CC)C2,3.781100000000002
+82885,Modify the molecule CN(C(=O)c1cc2ccccc2n1C)[C@@H]1CCCC[C@H]1S(C)(=O)=O to have a higher LogP value.,CN(C(=O)c1cc2ccccc2n1C)[C@@H]1CCCC[C@H]1S(C)(=O)=O,2.6061000000000005
+37855,Modify the molecule C#CC[NH+]1CCC[C@H]1COC(=O)c1cnc2c(C)cccn2c1=O to increase its LogP value.,C#CC[NH+]1CCC[C@H]1COC(=O)c1cnc2c(C)cccn2c1=O,-0.15978000000000026
+57902,Please optimize the molecule Cc1cc(Cl)ncc1NC(=O)C(=O)N[C@H]1C[C@H]2CCCc3cccc1c32 to have a higher LogP value.,Cc1cc(Cl)ncc1NC(=O)C(=O)N[C@H]1C[C@H]2CCCc3cccc1c32,3.663020000000003
+89548,Modify the molecule Cc1cn2c3c(=O)n(CC[NH+]4CCCCC4)c(=O)n(C)c3nc2n1-c1ccc(Cl)cc1 to increase its LogP value.,Cc1cn2c3c(=O)n(CC[NH+]4CCCCC4)c(=O)n(C)c3nc2n1-c1ccc(Cl)cc1,1.16922
+11408,Modify the molecule O=C(CC1CC1)c1scc(Br)c1Br to decrease its LogP value.,O=C(CC1CC1)c1scc(Br)c1Br,4.255900000000001
+30507,Please optimize the molecule FCCC[NH+]1CCC[C@H](c2nncn2C2CC2)C1 to have a lower LogP value.,FCCC[NH+]1CCC[C@H](c2nncn2C2CC2)C1,0.7348999999999994
+210334,Modify the molecule COc1cc(C[NH2+]Cc2ccccn2)ccc1OC(F)F to decrease its LogP value.,COc1cc(C[NH2+]Cc2ccccn2)ccc1OC(F)F,1.9551999999999994
+53937,Modify the molecule CC(C)NC(=O)c1cccc(S(=O)(=O)[C@@H]2CCS(=O)(=O)C2)c1 to have a lower LogP value.,CC(C)NC(=O)c1cccc(S(=O)(=O)[C@@H]2CCS(=O)(=O)C2)c1,0.7855999999999999
+189009,Please modify the molecule CSc1ccccc1Oc1cncc(C[NH2+]CC(C)C)n1 to decrease its LogP value.,CSc1ccccc1Oc1cncc(C[NH2+]CC(C)C)n1,2.7102000000000004
+138514,Please modify the molecule CNC(=S)Nc1n[nH]c(SC)n1 to increase its LogP value.,CNC(=S)Nc1n[nH]c(SC)n1,0.4427999999999998
+121280,Please modify the molecule CCN(C(=O)c1cncc(Br)c1)c1ccc2ccccc2c1 to increase its LogP value.,CCN(C(=O)c1cncc(Br)c1)c1ccc2ccccc2c1,4.664000000000003
+165164,Please modify the molecule COc1cccc(CNC(=O)Nc2cnn(C[C@@H]3CCCO3)c2)c1 to increase its LogP value.,COc1cccc(CNC(=O)Nc2cnn(C[C@@H]3CCCO3)c2)c1,2.3924000000000003
+239937,Modify the molecule Clc1cccc(Cl)c1N[C@@H]1CCO[C@@]2(CCOC2)C1 to have a higher LogP value.,Clc1cccc(Cl)c1N[C@@H]1CCO[C@@]2(CCOC2)C1,3.743400000000003
+165559,Modify the molecule CCc1nn(C)cc1C[NH2+][C@@H]1CCCSC1 to have a higher LogP value.,CCc1nn(C)cc1C[NH2+][C@@H]1CCCSC1,0.9415000000000001
+73100,Please modify the molecule COC(=O)c1sc(NC(=O)OC(C)(C)C)nc1C to decrease its LogP value.,COC(=O)c1sc(NC(=O)OC(C)(C)C)nc1C,2.5851200000000008
+165773,Optimize the molecule CN(Cc1ccccc1)C(=O)c1c[nH]nc1[C@H]1CCCN(Cc2ccccc2F)C1 to have a higher LogP value.,CN(Cc1ccccc1)C(=O)c1c[nH]nc1[C@H]1CCCN(Cc2ccccc2F)C1,4.200600000000003
+90114,Please optimize the molecule COc1ccc(-c2noc(C[NH+]3CC[C@@H](C(N)=O)C3)n2)cc1 to have a higher LogP value.,COc1ccc(-c2noc(C[NH+]3CC[C@@H](C(N)=O)C3)n2)cc1,-0.36469999999999847
+195586,Modify the molecule Cc1ccc(N[C@H](C)C(=O)N(C)CCC#N)cc1Cl to increase its LogP value.,Cc1ccc(N[C@H](C)C(=O)N(C)CCC#N)cc1Cl,2.820900000000001
+236930,Optimize the molecule CC[C@H](C#N)Oc1cccc(C[NH2+][C@@H](C)c2ccc(C)cc2)c1 to have a higher LogP value.,CC[C@H](C#N)Oc1cccc(C[NH2+][C@@H](C)c2ccc(C)cc2)c1,3.500600000000002
+104327,Modify the molecule CCOC(=O)C1C(C)=NC2=C(C(=O)[C@H](C(=O)OC)[C@@H](C)C2)[C@H]1c1ccc(SC)cc1 to have a higher LogP value.,CCOC(=O)C1C(C)=NC2=C(C(=O)[C@H](C(=O)OC)[C@@H](C)C2)[C@H]1c1ccc(SC)cc1,3.7981000000000034
+190947,Please modify the molecule c1nc(N2CCOCC2)ncc1CNCC1([NH+]2CCCCC2)CCCCC1 to increase its LogP value.,c1nc(N2CCOCC2)ncc1CNCC1([NH+]2CCCCC2)CCCCC1,1.1745000000000012
+33733,Optimize the molecule CC[C@H](C)NC(=O)C(=O)Nc1cc(Cl)ccc1C(=O)N1CCCC1 to have a lower LogP value.,CC[C@H](C)NC(=O)C(=O)Nc1cc(Cl)ccc1C(=O)N1CCCC1,2.4292000000000007
+211622,Please optimize the molecule COC(=O)CN(C(C)C)S(=O)(=O)c1cc(C)ccc1C to have a higher LogP value.,COC(=O)CN(C(C)C)S(=O)(=O)c1cc(C)ccc1C,1.8755399999999998
+31962,Please optimize the molecule Cc1ccc(CNC(=O)CN(C)S(=O)(=O)c2ccc3c(c2)CCCC(=O)N3)o1 to have a lower LogP value.,Cc1ccc(CNC(=O)CN(C)S(=O)(=O)c2ccc3c(c2)CCCC(=O)N3)o1,1.7997200000000002
+249316,Optimize the molecule CC(C)Cc1nnc(NC(=O)c2cccc(-n3nc([O-])ccc3=O)c2)s1 to have a higher LogP value.,CC(C)Cc1nnc(NC(=O)c2cccc(-n3nc([O-])ccc3=O)c2)s1,1.6083999999999998
+118077,Modify the molecule O=C1COc2ncc(C(=O)N[C@@H](C(=O)Nc3ccccc3)c3ccccc3)cc2N1 to decrease its LogP value.,O=C1COc2ncc(C(=O)N[C@@H](C(=O)Nc3ccccc3)c3ccccc3)cc2N1,2.5222999999999995
+195849,Modify the molecule C[C@H](NC(=O)COc1ccc(C(=O)[O-])cc1)C1CC1 to have a lower LogP value.,C[C@H](NC(=O)COc1ccc(C(=O)[O-])cc1)C1CC1,0.3435999999999997
+126689,Modify the molecule C[NH+]1CCCC[C@H]1CN1CCN(Cc2cc(-c3ccccc3)[nH]n2)CC1 to increase its LogP value.,C[NH+]1CCCC[C@H]1CN1CCN(Cc2cc(-c3ccccc3)[nH]n2)CC1,1.2615000000000014
+172407,Modify the molecule CCOc1ccc(C(=O)NC(=S)Nc2nnn(C)n2)cc1 to decrease its LogP value.,CCOc1ccc(C(=O)NC(=S)Nc2nnn(C)n2)cc1,0.7355999999999995
+149368,Modify the molecule CCC(C)(C)N(C)C(=O)/C=C/c1cccc(C)c1 to decrease its LogP value.,CCC(C)(C)N(C)C(=O)/C=C/c1cccc(C)c1,3.6552200000000026
+60436,Optimize the molecule COC(=O)c1ccc(NCC2CCOCC2)c(F)c1F to have a lower LogP value.,COC(=O)c1ccc(NCC2CCOCC2)c(F)c1F,2.589900000000001
+73484,Please optimize the molecule Cc1nn(C)cc1CN(C)C(=O)C[C@@H]1C(=O)NCC[NH+]1Cc1ccc2ccccc2c1 to have a higher LogP value.,Cc1nn(C)cc1CN(C)C(=O)C[C@@H]1C(=O)NCC[NH+]1Cc1ccc2ccccc2c1,0.8137200000000018
+140527,Modify the molecule Cn1nccc1CNC(=O)NC[C@@H]1CCC[C@H]1O to have a lower LogP value.,Cn1nccc1CNC(=O)NC[C@@H]1CCC[C@H]1O,0.38029999999999947
+152837,Please optimize the molecule COCCc1noc(-c2cc(Cl)ccc2NC(=O)[C@@H]2CCCS2)n1 to have a higher LogP value.,COCCc1noc(-c2cc(Cl)ccc2NC(=O)[C@@H]2CCCS2)n1,3.413000000000001
+67997,Optimize the molecule O=C(Nc1nnn[n-]1)c1ccc(OCC(F)F)nc1 to have a higher LogP value.,O=C(Nc1nnn[n-]1)c1ccc(OCC(F)F)nc1,0.11999999999999988
+116798,Please modify the molecule C=CC[NH+]1CCC(NC(=O)N2CCN(CCOC(C)C)CC2)CC1 to decrease its LogP value.,C=CC[NH+]1CCC(NC(=O)N2CCN(CCOC(C)C)CC2)CC1,-0.028099999999996017
+212251,Please modify the molecule CC(=O)c1ccc(NC[C@@H](c2ccc(F)cc2)N2CCOCC2)c([N+](=O)[O-])c1 to increase its LogP value.,CC(=O)c1ccc(NC[C@@H](c2ccc(F)cc2)N2CCOCC2)c([N+](=O)[O-])c1,3.4219000000000017
+200676,Optimize the molecule Cn1ccs/c1=N\C(=O)Nc1ccccc1 to have a higher LogP value.,Cn1ccs/c1=N\C(=O)Nc1ccccc1,2.2194000000000003
+78235,Please optimize the molecule Cc1ccccc1C[C@@H](C)NC(=O)CN(C)CC#N to have a higher LogP value.,Cc1ccccc1C[C@@H](C)NC(=O)CN(C)CC#N,1.4976
+52360,Optimize the molecule CNC(=O)c1ccc(C[S@](=O)[C@H](C)C(=O)Nc2ccccc2F)cc1 to have a higher LogP value.,CNC(=O)c1ccc(C[S@](=O)[C@H](C)C(=O)Nc2ccccc2F)cc1,2.4612000000000007
+169616,Modify the molecule CS[C@@H](C)c1cccc(NC(=O)c2c(C)c(C)nn(C)c2=O)c1 to decrease its LogP value.,CS[C@@H](C)c1cccc(NC(=O)c2c(C)c(C)nn(C)c2=O)c1,3.0734400000000015
+117239,Optimize the molecule c1ccc(Oc2ccc3c(c2)c2c4n3CC[NH2+][C@@H]4CCC2)cc1 to have a higher LogP value.,c1ccc(Oc2ccc3c(c2)c2c4n3CC[NH2+][C@@H]4CCC2)cc1,3.3880000000000017
+70124,Optimize the molecule O=C(NC1CCCCC1)NC1C[C@@H]2CCC[C@H](C1)[NH2+]2 to have a higher LogP value.,O=C(NC1CCCCC1)NC1C[C@@H]2CCC[C@H](C1)[NH2+]2,1.2652000000000005
+70768,Please optimize the molecule Cc1nc2c(cnn2C(C)C)cc1C(=O)NCc1ccc(NC(=O)C2CC2)cc1 to have a higher LogP value.,Cc1nc2c(cnn2C(C)C)cc1C(=O)NCc1ccc(NC(=O)C2CC2)cc1,3.599120000000002
+49820,Modify the molecule CCCOc1ccc(CNC(=O)N[C@H](C)c2nc(C)cs2)cc1 to decrease its LogP value.,CCCOc1ccc(CNC(=O)N[C@H](C)c2nc(C)cs2)cc1,3.800720000000002
+174735,Modify the molecule COc1ccc2nc(C[NH+]3CCC(c4nnc(-c5ccncc5)o4)CC3)ccc2c1 to have a lower LogP value.,COc1ccc2nc(C[NH+]3CCC(c4nnc(-c5ccncc5)o4)CC3)ccc2c1,2.650900000000001
+91753,Please optimize the molecule O=C(CCCl)Nc1ccc(NC(=O)c2ccccc2)cc1 to have a lower LogP value.,O=C(CCCl)Nc1ccc(NC(=O)c2ccccc2)cc1,3.5063000000000013
+95220,Modify the molecule N#Cc1cc(NC(=O)C2(O)Cc3ccccc3C2)ccc1F to decrease its LogP value.,N#Cc1cc(NC(=O)C2(O)Cc3ccccc3C2)ccc1F,2.16578
+76239,Please optimize the molecule CO[C@@H](C)c1cccc(NC(=O)C(=O)N[C@H](C)c2cn(C)nc2C)c1 to have a lower LogP value.,CO[C@@H](C)c1cccc(NC(=O)C(=O)N[C@H](C)c2cn(C)nc2C)c1,2.2518200000000004
+34817,Please optimize the molecule Cc1cc(C)c2c(c1)[C@H]([NH2+]C[C@H]1CCCS1(=O)=O)CCO2 to have a higher LogP value.,Cc1cc(C)c2c(c1)[C@H]([NH2+]C[C@H]1CCCS1(=O)=O)CCO2,1.2676399999999999
+83212,Modify the molecule COc1ccccc1Nc1ncccc1C(=O)Nc1ccc(C)c(S(N)(=O)=O)c1 to decrease its LogP value.,COc1ccccc1Nc1ncccc1C(=O)Nc1ccc(C)c(S(N)(=O)=O)c1,3.04192
+51571,Optimize the molecule C[C@H]1CN(c2ccc(C#N)c([N+](=O)[O-])c2)C[C@@H]1C to have a lower LogP value.,C[C@H]1CN(c2ccc(C#N)c([N+](=O)[O-])c2)C[C@@H]1C,2.5586800000000007
+113766,Please modify the molecule CCc1nc(CNc2cccc(Cl)c2-n2cccn2)no1 to decrease its LogP value.,CCc1nc(CNc2cccc(Cl)c2-n2cccn2)no1,3.0832000000000006
+12651,Please modify the molecule C[C@H]1Oc2ccccc2N(CCC(=O)N(Cc2cccs2)C[C@H]2CCCO2)C1=O to increase its LogP value.,C[C@H]1Oc2ccccc2N(CCC(=O)N(Cc2cccs2)C[C@H]2CCCO2)C1=O,3.459900000000002
+10149,Optimize the molecule Cc1noc(CN2CCOC[C@@H]2C2CC2)n1 to have a lower LogP value.,Cc1noc(CN2CCOC[C@@H]2C2CC2)n1,0.9888199999999998
+2327,Please modify the molecule COc1ccc(-c2onc(C(=O)c3ccc([N+](=O)[O-])cc3)c2S(=O)(=O)c2ccccc2)cc1 to increase its LogP value.,COc1ccc(-c2onc(C(=O)c3ccc([N+](=O)[O-])cc3)c2S(=O)(=O)c2ccccc2)cc1,4.322200000000003
+192255,Optimize the molecule CC(C)N(C)C(=O)[C@@H](C)S(=O)(=O)c1ccccc1 to have a lower LogP value.,CC(C)N(C)C(=O)[C@@H](C)S(=O)(=O)c1ccccc1,1.7156
+36246,Please optimize the molecule CCOc1cc2oc(=O)cc(C)c2cc1CC to have a higher LogP value.,CCOc1cc2oc(=O)cc(C)c2cc1CC,3.062520000000002
+136768,Please modify the molecule CC(C)Oc1ccc([C@@H]2CC(=O)Nc3c(C(=O)[O-])nsc32)cc1 to increase its LogP value.,CC(C)Oc1ccc([C@@H]2CC(=O)Nc3c(C(=O)[O-])nsc32)cc1,1.7678999999999998
+204257,Modify the molecule CCOC(=O)C[C@@H](C)[C@H]1CCCN(c2ncnc3nc(N)ccc23)C1 to increase its LogP value.,CCOC(=O)C[C@@H](C)[C@H]1CCCN(c2ncnc3nc(N)ccc23)C1,2.4127
+131602,Optimize the molecule CCCCCn1c(N)c(-c2nc3ccccc3o2)c2c([N+](=O)[O-])nn(C)c(=O)c21 to have a higher LogP value.,CCCCCn1c(N)c(-c2nc3ccccc3o2)c2c([N+](=O)[O-])nn(C)c(=O)c21,3.2238000000000016
+101124,Please modify the molecule C[C@@H]1CCC[C@@H](NC(=S)NNC(=O)c2cccc(-n3cccn3)n2)[C@@H]1C to decrease its LogP value.,C[C@@H]1CCC[C@@H](NC(=S)NNC(=O)c2cccc(-n3cccn3)n2)[C@@H]1C,2.2009
+230520,Modify the molecule CN(C[C@@H]1CCC[NH+]1C)[C@@H](C[NH3+])c1cc(Br)ccc1F to increase its LogP value.,CN(C[C@@H]1CCC[NH+]1C)[C@@H](C[NH3+])c1cc(Br)ccc1F,0.4801000000000017
+245554,Optimize the molecule COCCN(CC(=O)N(C)C)c1ccc2nnc(C)n2n1 to have a lower LogP value.,COCCN(CC(=O)N(C)C)c1ccc2nnc(C)n2n1,-0.02628000000000008
+228186,Optimize the molecule CCC(=O)N1CC[C@@H](NC(=O)Nc2ccnn2Cc2ccccn2)C1 to have a lower LogP value.,CCC(=O)N1CC[C@@H](NC(=O)Nc2ccnn2Cc2ccccn2)C1,1.4587999999999994
+83493,Modify the molecule C[C@@H](C(=O)N(C)Cc1ccccc1)[S@](=O)Cc1ncc(Cl)n1C to increase its LogP value.,C[C@@H](C(=O)N(C)Cc1ccccc1)[S@](=O)Cc1ncc(Cl)n1C,2.3693
+228527,Modify the molecule Cc1ccc([C@@H](CNC(=O)C2CCCCC2)N2CCOCC2)o1 to increase its LogP value.,Cc1ccc([C@@H](CNC(=O)C2CCCCC2)N2CCOCC2)o1,2.657820000000001
+133453,Please optimize the molecule Cc1cc(C)n(C2CN(C(=O)c3cnn4ccn(C)c34)C2)n1 to have a lower LogP value.,Cc1cc(C)n(C2CN(C(=O)c3cnn4ccn(C)c34)C2)n1,1.1832399999999998
+114260,Modify the molecule O[C@@H](c1ccc(F)c(F)c1)[C@@H]1CCOC2(CCC2)C1 to have a higher LogP value.,O[C@@H](c1ccc(F)c(F)c1)[C@@H]1CCOC2(CCC2)C1,3.347500000000002
+162559,Please modify the molecule CCO[n+]1ccc(-c2cc[n+](OCC)cc2)cc1 to decrease its LogP value.,CCO[n+]1ccc(-c2cc[n+](OCC)cc2)cc1,0.8255999999999997
+140367,Optimize the molecule COc1ccccc1NC(=O)c1ccc(-n2cccn2)nn1 to have a higher LogP value.,COc1ccccc1NC(=O)c1ccc(-n2cccn2)nn1,1.9231999999999996
+76583,Modify the molecule Cc1ccc(CN2C(=O)[C@H]3CCCC[C@@H]3C2=O)cc1S(=O)(=O)Nc1cccc(Cl)c1C to have a higher LogP value.,Cc1ccc(CN2C(=O)[C@H]3CCCC[C@@H]3C2=O)cc1S(=O)(=O)Nc1cccc(Cl)c1C,4.432840000000003
+136785,Modify the molecule CSC[C@@H](C)NC(=O)N(CC1CC1)[C@H](C)c1ccccc1 to increase its LogP value.,CSC[C@@H](C)NC(=O)N(CC1CC1)[C@H](C)c1ccccc1,3.9207000000000036
+105205,Modify the molecule CN(C)C(C)(C)[C@H]([NH3+])[C@H]1CCOC2(CCC2)C1 to increase its LogP value.,CN(C)C(C)(C)[C@H]([NH3+])[C@H]1CCOC2(CCC2)C1,1.2864
+226338,Please optimize the molecule Cc1nc(CC(C)C)sc1C(=O)NC[C@](C)(O)c1ccsc1 to have a lower LogP value.,Cc1nc(CC(C)C)sc1C(=O)NC[C@](C)(O)c1ccsc1,3.349020000000002
+130635,Please modify the molecule CCCN(C(=O)c1[nH]c(C)c(C(=O)OCC)c1C)[C@H]1CCc2ccccc2C1 to decrease its LogP value.,CCCN(C(=O)c1[nH]c(C)c(C(=O)OCC)c1C)[C@H]1CCc2ccccc2C1,4.217940000000004
+205789,Please modify the molecule CO[C@@H](C)C(=O)NCCOc1ccc(C)cc1 to decrease its LogP value.,CO[C@@H](C)C(=O)NCCOc1ccc(C)cc1,1.5249199999999996
+233851,Modify the molecule Cc1ccc2oc(C(=O)Nc3cccc(C(F)(F)F)c3)cc2n1 to have a lower LogP value.,Cc1ccc2oc(C(=O)Nc3cccc(C(F)(F)F)c3)cc2n1,4.407320000000002
+28864,Modify the molecule C[C@@H]1CCC[C@H](N(Cc2ccc3c(c2)OCO3)C(=O)Nc2cc3c(cc2Cl)NC(=O)CO3)[C@@H]1C to decrease its LogP value.,C[C@@H]1CCC[C@H](N(Cc2ccc3c(c2)OCO3)C(=O)Nc2cc3c(cc2Cl)NC(=O)CO3)[C@@H]1C,5.258400000000004
+22456,Modify the molecule CC[C@H](C)[C@H](C(=O)Nc1nnc(N)s1)c1ccccc1 to have a higher LogP value.,CC[C@H](C)[C@H](C(=O)Nc1nnc(N)s1)c1ccccc1,2.888700000000001
+27273,Modify the molecule ClCc1cnc(-c2cccs2)nc1 to decrease its LogP value.,ClCc1cnc(-c2cccs2)nc1,2.943900000000001
+92806,Please modify the molecule O=C(NCc1ccnc(Oc2ccc(F)cc2)c1)N1CCOC[C@H]1C1CC1 to increase its LogP value.,O=C(NCc1ccnc(Oc2ccc(F)cc2)c1)N1CCOC[C@H]1C1CC1,3.333400000000002
+15037,Optimize the molecule COc1cc(NC2CC[NH+]([C@H](C)C(=O)NC3CCCC3)CC2)cc(OC)c1 to have a lower LogP value.,COc1cc(NC2CC[NH+]([C@H](C)C(=O)NC3CCCC3)CC2)cc(OC)c1,1.6103
+136878,Please optimize the molecule CC(=O)Nc1cc(Nc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])ccc1C to have a higher LogP value.,CC(=O)Nc1cc(Nc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])ccc1C,3.5134200000000018
+1914,Please optimize the molecule Cc1ccccc1NC(=O)N1CCN(Cc2cc(=O)n3nc(-c4ccccc4F)sc3n2)CC1 to have a higher LogP value.,Cc1ccccc1NC(=O)N1CCN(Cc2cc(=O)n3nc(-c4ccccc4F)sc3n2)CC1,3.6152200000000025
+141937,Please modify the molecule COCCNC(=O)[C@H](C)N1CCc2cc(Br)sc2C1 to decrease its LogP value.,COCCNC(=O)[C@H](C)N1CCc2cc(Br)sc2C1,2.0198
+95055,Optimize the molecule Cc1noc(C)c1C[NH+]1CCC(C[NH+](C)Cc2ccccc2)CC1 to have a higher LogP value.,Cc1noc(C)c1C[NH+]1CCC(C[NH+](C)Cc2ccccc2)CC1,0.8012400000000024
+149243,Modify the molecule N#C[C@]1(N)CCC[C@H]1CCOc1ccc([N+](=O)[O-])cc1 to decrease its LogP value.,N#C[C@]1(N)CCC[C@H]1CCOc1ccc([N+](=O)[O-])cc1,2.3848800000000008
+6409,Modify the molecule Cc1cc(NC(=O)C(=O)c2ccc(C(C)(C)C)cc2)n(C)n1 to have a lower LogP value.,Cc1cc(NC(=O)C(=O)c2ccc(C(C)(C)C)cc2)n(C)n1,2.8474200000000014
+174214,Optimize the molecule CN1CCO[C@@H](C[NH2+]CC2CCCCCC2)C1 to have a higher LogP value.,CN1CCO[C@@H](C[NH2+]CC2CCCCCC2)C1,0.8508000000000004
+99942,Please modify the molecule COc1ccc(Cl)cc1NC(=O)CCNS(=O)(=O)c1ccc(C)cc1 to increase its LogP value.,COc1ccc(Cl)cc1NC(=O)CCNS(=O)(=O)c1ccc(C)cc1,2.964120000000001
+205986,Please optimize the molecule Cc1ccc(OC[C@H]2CCCN(C(=O)CCc3cnn(C)c3)C2)cc1 to have a higher LogP value.,Cc1ccc(OC[C@H]2CCCN(C(=O)CCc3cnn(C)c3)C2)cc1,2.978720000000002
+9662,Modify the molecule CC(C)OCCN1CCN(C(=O)[C@H](C(C)C)N2C[C@@H](C)O[C@H](C)C2)CC1 to have a higher LogP value.,CC(C)OCCN1CCN(C(=O)[C@H](C(C)C)N2C[C@@H](C)O[C@H](C)C2)CC1,1.6894000000000013
+135965,Modify the molecule CCCCC(=O)[C@H]1CCCc2cccnc21 to increase its LogP value.,CCCCC(=O)[C@H]1CCCc2cccnc21,3.2608000000000024
+139821,Modify the molecule O=C(CSc1nc2ccccc2[nH]1)N/N=C1/C(=O)N(Cc2ccccc2)c2ccccc21 to have a higher LogP value.,O=C(CSc1nc2ccccc2[nH]1)N/N=C1/C(=O)N(Cc2ccccc2)c2ccccc21,3.7223000000000024
+187740,Modify the molecule CCOc1ccc([C@H](O)C[NH+]2CCC(C)(C)C2)cc1 to increase its LogP value.,CCOc1ccc([C@H](O)C[NH+]2CCC(C)(C)C2)cc1,1.4334999999999996
+19169,Modify the molecule CCn1c(=O)n(CCC(=O)N2CCC[C@@H]2c2ccc(OC)c(OC)c2)c2ccccc21 to have a higher LogP value.,CCn1c(=O)n(CCC(=O)N2CCC[C@@H]2c2ccc(OC)c(OC)c2)c2ccccc21,3.5939000000000023
+46840,Modify the molecule Cc1cc(NC(=O)C(=O)NCC2CCN(C(=O)/C=C/c3ccco3)CC2)c2ccccc2n1 to decrease its LogP value.,Cc1cc(NC(=O)C(=O)NCC2CCN(C(=O)/C=C/c3ccco3)CC2)c2ccccc2n1,3.142920000000001
+12751,Please optimize the molecule O=C(Cn1ncn(-n2cccc2)c1=S)Nc1ccc(F)cc1F to have a higher LogP value.,O=C(Cn1ncn(-n2cccc2)c1=S)Nc1ccc(F)cc1F,2.4438899999999997
+214064,Please optimize the molecule Cc1[nH+]ccn1CCOc1c(F)cc(C[C@@H](C)[NH3+])cc1F to have a higher LogP value.,Cc1[nH+]ccn1CCOc1c(F)cc(C[C@@H](C)[NH3+])cc1F,1.1407199999999997
+6491,Optimize the molecule C[C@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)[O-] to have a higher LogP value.,C[C@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)[O-],0.5232999999999997
+249091,Modify the molecule O=C(CNC(=O)NCCCN1CCCCCC1=O)Nc1ccc(F)c(F)c1 to have a higher LogP value.,O=C(CNC(=O)NCCCN1CCCCCC1=O)Nc1ccc(F)c(F)c1,1.9951999999999992
+85589,Optimize the molecule Cn1c(C(=O)N2CCCO[C@H](Cn3cccn3)C2)cc(=O)n(C)c1=O to have a lower LogP value.,Cn1c(C(=O)N2CCCO[C@H](Cn3cccn3)C2)cc(=O)n(C)c1=O,-0.7881999999999985
+236403,Modify the molecule Cc1nc(CCC[S@](=O)C2CCCC2)cs1 to have a lower LogP value.,Cc1nc(CCC[S@](=O)C2CCCC2)cs1,3.075420000000002
+97449,Modify the molecule Cc1ccc(C)c(S(=O)(=O)c2nnn3c2nc(N(C)Cc2ccccc2)c2sccc23)c1 to have a higher LogP value.,Cc1ccc(C)c(S(=O)(=O)c2nnn3c2nc(N(C)Cc2ccccc2)c2sccc23)c1,4.425040000000004
+7182,Modify the molecule NS(=O)(=O)c1ccc(Cl)c(C(=O)NCc2ccco2)c1 to have a higher LogP value.,NS(=O)(=O)c1ccc(Cl)c(C(=O)NCc2ccco2)c1,1.5104000000000002
+198493,Modify the molecule COC[C@H](C)NC(=O)c1ccccc1SC[C@H]1CCCO1 to decrease its LogP value.,COC[C@H](C)NC(=O)c1ccccc1SC[C@H]1CCCO1,2.7224000000000013
+171506,Optimize the molecule Cc1ccc(C)c(NC(=O)COC(=O)c2cccc(N(C)C)c2)c1 to have a lower LogP value.,Cc1ccc(C)c(NC(=O)COC(=O)c2cccc(N(C)C)c2)c1,3.1649400000000014
+75170,Please optimize the molecule CCCCn1c(N)c(N(Cc2ccccc2)C(=O)c2ccc(Cl)c(Cl)c2)c(=O)[nH]c1=O to have a higher LogP value.,CCCCn1c(N)c(N(Cc2ccccc2)C(=O)c2ccc(Cl)c(Cl)c2)c(=O)[nH]c1=O,4.072700000000002
+60509,Modify the molecule C[C@@H](NC(=O)N(C1CC1)[C@H](C)C1CC1)c1ccc(-c2ccncc2)cc1 to decrease its LogP value.,C[C@@H](NC(=O)N(C1CC1)[C@H](C)C1CC1)c1ccc(-c2ccncc2)cc1,4.782100000000004
+150118,Please modify the molecule CCC1CN(c2cccc(F)c2C(=O)[O-])C1 to decrease its LogP value.,CCC1CN(c2cccc(F)c2C(=O)[O-])C1,1.0353999999999999
+8165,Modify the molecule COc1ccc([C@H]2C(C#N)=C(N)Oc3cc(C)n(Cc4ccccc4)c(=O)c32)cc1OC to have a lower LogP value.,COc1ccc([C@H]2C(C#N)=C(N)Oc3cc(C)n(Cc4ccccc4)c(=O)c32)cc1OC,3.440400000000002
+224654,Modify the molecule CN(C)CN1C(=O)/C(=N\c2sc3c(c2C#N)CCCC3)c2cc(Br)ccc21 to decrease its LogP value.,CN(C)CN1C(=O)/C(=N\c2sc3c(c2C#N)CCCC3)c2cc(Br)ccc21,4.247580000000004
+78271,Optimize the molecule O=C(c1cccc2c1N[C@@H](c1cccc3ccccc13)[C@H]1CC=C[C@H]21)N1CCCC1 to have a lower LogP value.,O=C(c1cccc2c1N[C@@H](c1cccc3ccccc13)[C@H]1CC=C[C@H]21)N1CCCC1,5.902300000000005
+179089,Please optimize the molecule Cc1ccc(-c2cc(C(=O)Nc3nccs3)no2)cc1F to have a higher LogP value.,Cc1ccc(-c2cc(C(=O)Nc3nccs3)no2)cc1F,3.4979200000000015
+67122,Optimize the molecule CC(=O)Nc1cccc2c1CCN(C(=O)c1[nH]c3ccccc3c1Cl)C2 to have a lower LogP value.,CC(=O)Nc1cccc2c1CCN(C(=O)c1[nH]c3ccccc3c1Cl)C2,3.978200000000002
+233330,Please modify the molecule O=C([O-])c1cc2n[nH]cc2cc1[N+](=O)[O-] to increase its LogP value.,O=C([O-])c1cc2n[nH]cc2cc1[N+](=O)[O-],-0.16540000000000016
+35493,Modify the molecule CCOc1ccc(CCC2CCN(C(=O)c3cccnc3-n3cncn3)CC2)cc1 to increase its LogP value.,CCOc1ccc(CCC2CCN(C(=O)c3cccnc3-n3cncn3)CC2)cc1,3.546000000000002
+109197,Modify the molecule Cc1c(OCC(=O)NC(=O)N[C@@H]2CCCC[C@H]2C)cccc1[N+](=O)[O-] to increase its LogP value.,Cc1c(OCC(=O)NC(=O)N[C@@H]2CCCC[C@H]2C)cccc1[N+](=O)[O-],2.6865200000000007
+175039,Modify the molecule C#CCN(CC#C)C(=O)c1cncc(C(=O)N(CC#C)CC#C)c1 to have a higher LogP value.,C#CCN(CC#C)C(=O)c1cncc(C(=O)N(CC#C)CC#C)c1,0.49880000000000013
+170371,Optimize the molecule Cn1ncc2c(=O)n(CC(=O)c3ccc4c(c3)OCCO4)cnc21 to have a lower LogP value.,Cn1ncc2c(=O)n(CC(=O)c3ccc4c(c3)OCCO4)cnc21,0.7840999999999995
+9842,Modify the molecule C[C@@H](OC1=C[C@H]2[NH+]=c3ccccc3=C2C=C1)C(=O)Nc1ccc(S(N)(=O)=O)cc1 to have a higher LogP value.,C[C@@H](OC1=C[C@H]2[NH+]=c3ccccc3=C2C=C1)C(=O)Nc1ccc(S(N)(=O)=O)cc1,-0.9353999999999969
+245056,Modify the molecule CCOc1ccc(C(=O)Nc2nnc(-c3ccc4c(c3)OCCO4)o2)cc1 to increase its LogP value.,CCOc1ccc(C(=O)Nc2nnc(-c3ccc4c(c3)OCCO4)o2)cc1,3.158800000000001
+125240,Modify the molecule CC(C)n1ncc2cc(/C=C/C(=O)Oc3ccccc3Cl)c(=O)[nH]c21 to increase its LogP value.,CC(C)n1ncc2cc(/C=C/C(=O)Oc3ccccc3Cl)c(=O)[nH]c21,3.577700000000002
+63053,Optimize the molecule O=c1c(/C([O-])=N/c2nc(-c3ccc(Cl)cc3)cs2)c[nH]c2cc(F)cc(F)c12 to have a lower LogP value.,O=c1c(/C([O-])=N/c2nc(-c3ccc(Cl)cc3)cs2)c[nH]c2cc(F)cc(F)c12,4.021800000000002
+191532,Optimize the molecule O=C([O-])[C@H](Sc1nnc(-c2ccncc2)n1-c1ccccc1)c1ccccc1 to have a higher LogP value.,O=C([O-])[C@H](Sc1nnc(-c2ccncc2)n1-c1ccccc1)c1ccccc1,2.912600000000001
+212819,Please modify the molecule O=Cc1cc([N+](=O)[O-])ccc1OCc1cc(=O)oc2cc3c(cc12)CCC3 to increase its LogP value.,O=Cc1cc([N+](=O)[O-])ccc1OCc1cc(=O)oc2cc3c(cc12)CCC3,3.581400000000002
+218501,Optimize the molecule C[C@H](C(N)=O)N1CCN(Cc2cnc(-c3cccs3)s2)CC1 to have a lower LogP value.,C[C@H](C(N)=O)N1CCN(Cc2cnc(-c3cccs3)s2)CC1,1.8630000000000002
+176144,Please modify the molecule Cc1ccccc1CNC(=O)CCc1ccc2[nH]ccc2c1 to increase its LogP value.,Cc1ccccc1CNC(=O)CCc1ccc2[nH]ccc2c1,3.7253200000000017
+80342,Optimize the molecule Cc1ccc(C(=O)Nc2ccc3c(c2)nc2n3CCSC2)cc1 to have a lower LogP value.,Cc1ccc(C(=O)Nc2ccc3c(c2)nc2n3CCSC2)cc1,3.843820000000002
+43491,Optimize the molecule COC(=O)C1=C(C)C(C(=O)c2cc3ccccc3o2)=N[C@H]1C to have a higher LogP value.,COC(=O)C1=C(C)C(C(=O)c2cc3ccccc3o2)=N[C@H]1C,2.948100000000001
+126075,Modify the molecule O=C(NCc1nnnn1-c1ccc(Cl)cc1)c1cccc2ccccc12 to have a lower LogP value.,O=C(NCc1nnnn1-c1ccc(Cl)cc1)c1cccc2ccccc12,3.398900000000002
+140046,Optimize the molecule C[C@H]1CCCCN1C(=O)Cn1c(CCCNC(=O)c2cccnc2)nc2ccccc21 to have a lower LogP value.,C[C@H]1CCCCN1C(=O)Cn1c(CCCNC(=O)c2cccnc2)nc2ccccc21,3.1949000000000014
+92290,Optimize the molecule Cc1ccc(C(=O)NNC(=O)N[C@H](CC(F)(F)F)c2ccc(F)cc2)s1 to have a lower LogP value.,Cc1ccc(C(=O)NNC(=O)N[C@H](CC(F)(F)F)c2ccc(F)cc2)s1,3.8333200000000014
+216726,Please optimize the molecule C[C@H](CO)N(C)C(=O)NC[C@H]1CCCN(c2ncccn2)C1 to have a higher LogP value.,C[C@H](CO)N(C)C(=O)NC[C@H]1CCCN(c2ncccn2)C1,0.7151999999999996
+164755,Optimize the molecule CN(CCN1CCOCC1)[C@@H](C(N)=O)c1ccccc1 to have a higher LogP value.,CN(CCN1CCOCC1)[C@@H](C(N)=O)c1ccccc1,0.4770000000000011
+171727,Modify the molecule C[C@@H](CC(=O)N1CC[NH2+]CC1)CC(C)(C)C to have a higher LogP value.,C[C@@H](CC(=O)N1CC[NH2+]CC1)CC(C)(C)C,0.8544
+113197,Please optimize the molecule CC[C@H]1C[NH+]2CCCC[C@@H]2CN1c1ccc2sccc2c1 to have a lower LogP value.,CC[C@H]1C[NH+]2CCCC[C@@H]2CN1c1ccc2sccc2c1,2.9373000000000014
+49061,Please optimize the molecule COc1cccc([C@H](CO)Nc2ccc(-n3ccc(C)n3)nn2)c1 to have a higher LogP value.,COc1cccc([C@H](CO)Nc2ccc(-n3ccc(C)n3)nn2)c1,2.1248199999999997
+68212,Please optimize the molecule CCc1nc2n(n1)[C@@H](C(=O)Nc1ccc(C(C)=O)cc1)CC(=O)N2 to have a lower LogP value.,CCc1nc2n(n1)[C@@H](C(=O)Nc1ccc(C(C)=O)cc1)CC(=O)N2,1.5650999999999997
+81989,Optimize the molecule C1C[NH2+]C[C@H](OCC2CC2)C1 to have a higher LogP value.,C1C[NH2+]C[C@H](OCC2CC2)C1,0.13880000000000026
+139308,Optimize the molecule COc1cccc(CCNC(=O)N(C)C[C@@H](C)O)c1 to have a lower LogP value.,COc1cccc(CCNC(=O)N(C)C[C@@H](C)O)c1,1.2598999999999998
+74611,Please modify the molecule O=c1ccc(-c2ccc(-n3ccnc3)cc2)n[nH]1 to decrease its LogP value.,O=c1ccc(-c2ccc(-n3ccnc3)cc2)n[nH]1,1.6225999999999998
+189474,Modify the molecule Cc1ccc(-c2csc3c(=O)[nH]c(N4CCC[C@H](C(=O)NCC(C)C)C4)nc23)cc1 to increase its LogP value.,Cc1ccc(-c2csc3c(=O)[nH]c(N4CCC[C@H](C(=O)NCC(C)C)C4)nc23)cc1,3.9486200000000027
+199947,Please modify the molecule COc1ccc(OC)c([C@@H](C)NCCc2ccncc2C)c1 to increase its LogP value.,COc1ccc(OC)c([C@@H](C)NCCc2ccncc2C)c1,3.3005200000000015
+209938,Please modify the molecule Cc1cnc(C[NH2+][C@@H](C)[C@@H](C)O)cn1 to increase its LogP value.,Cc1cnc(C[NH2+][C@@H](C)[C@@H](C)O)cn1,-0.3822799999999993
+176607,Optimize the molecule Cc1ccc(N2CCN(/N=C\c3ccc(C)o3)CC2)cc1 to have a higher LogP value.,Cc1ccc(N2CCN(/N=C\c3ccc(C)o3)CC2)cc1,3.0525400000000014
+32079,Modify the molecule C[C@@H]1C[NH+](Cc2ccc(C#CC[NH3+])cc2F)C[C@H]1C to increase its LogP value.,C[C@@H]1C[NH+](Cc2ccc(C#CC[NH3+])cc2F)C[C@H]1C,0.08980000000000121
+14804,Optimize the molecule O=C(NCCc1nnc2ccccn12)Nc1ccc(OC2CCCC2)cc1 to have a higher LogP value.,O=C(NCCc1nnc2ccccn12)Nc1ccc(OC2CCCC2)cc1,3.414900000000002
+200547,Modify the molecule Cc1[nH+]ccn1CC(=O)N1CCC[C@@H](c2nnc(C[NH+]3CCCC3)n2C)C1 to increase its LogP value.,Cc1[nH+]ccn1CC(=O)N1CCC[C@@H](c2nnc(C[NH+]3CCCC3)n2C)C1,-0.6759799999999963
+176551,Optimize the molecule C=C[C@H]1C[NH+]2CC[C@H]1C[C@@H]2CNC(=O)NC1CCCCC1 to have a higher LogP value.,C=C[C@H]1C[NH+]2CC[C@H]1C[C@@H]2CNC(=O)NC1CCCCC1,1.0976000000000008
+156858,Optimize the molecule Cc1c(NC(=O)c2cccc(NC(=O)[C@H]3CC=CC[C@H]3C(=O)[O-])c2)c(=O)n(-c2ccccc2)n1C to have a higher LogP value.,Cc1c(NC(=O)c2cccc(NC(=O)[C@H]3CC=CC[C@H]3C(=O)[O-])c2)c(=O)n(-c2ccccc2)n1C,2.0075199999999995
+34342,Optimize the molecule C[C@@H](NC(=O)CSCc1ccco1)c1ccccc1Cl to have a lower LogP value.,C[C@@H](NC(=O)CSCc1ccco1)c1ccccc1Cl,4.043600000000003
+154525,Modify the molecule Cc1ccc(C2=C[C@H]([C@H]3NN[C@H](SCC(=O)Nc4cccc(C(F)(F)F)c4)N3N)N=N2)cc1 to decrease its LogP value.,Cc1ccc(C2=C[C@H]([C@H]3NN[C@H](SCC(=O)Nc4cccc(C(F)(F)F)c4)N3N)N=N2)cc1,3.454220000000001
+103531,Modify the molecule COc1ccccc1[C@@H](NC(=O)NCC[NH+]1CCCCC1)c1ccccn1 to have a higher LogP value.,COc1ccccc1[C@@H](NC(=O)NCC[NH+]1CCCCC1)c1ccccn1,1.5476
+127093,Please optimize the molecule CCC(CC)CNC(=O)N1CCN(C(=O)[C@@H]2C[C@@H]2C)CC1 to have a lower LogP value.,CCC(CC)CNC(=O)N1CCN(C(=O)[C@@H]2C[C@@H]2C)CC1,1.9324
+223709,Please modify the molecule CC[C@H](O)c1ccn(C[C@@H]2Cc3cc(F)ccc3O2)c1 to decrease its LogP value.,CC[C@H](O)c1ccn(C[C@@H]2Cc3cc(F)ccc3O2)c1,3.074300000000002
+56820,Modify the molecule COc1ccccc1[C@H]1C[C@@H]1C(=O)N[C@@H]1CCCC[C@@H]1C(F)(F)F to have a lower LogP value.,COc1ccccc1[C@H]1C[C@@H]1C(=O)N[C@@H]1CCCC[C@@H]1C(F)(F)F,4.036000000000003
+201230,Please optimize the molecule C[C@@H]1C[C@H]1C(=O)N1CCC[C@@H]1C(=O)N1CCOCC1 to have a lower LogP value.,C[C@@H]1C[C@H]1C(=O)N1CCC[C@@H]1C(=O)N1CCOCC1,0.4922000000000002
+87270,Modify the molecule Nc1ccc(-n2cc(-c3cccc(Cl)c3)cn2)cc1 to have a lower LogP value.,Nc1ccc(-n2cc(-c3cccc(Cl)c3)cn2)cc1,3.7749000000000015
+202136,Please modify the molecule CC[NH2+][C@H](Cc1cccnc1)[C@@H](C)CC to decrease its LogP value.,CC[NH2+][C@H](Cc1cccnc1)[C@@H](C)CC,1.6220999999999994
+130805,Please modify the molecule C[C@H](NC(=O)C1(NS(C)(=O)=O)CCCCC1)C(=O)NC(C)(C)C to increase its LogP value.,C[C@H](NC(=O)C1(NS(C)(=O)=O)CCCCC1)C(=O)NC(C)(C)C,0.6578999999999997
+211612,Modify the molecule CC[NH+](Cc1ccc2c(c1)CC(C)(C)O2)[C@@H](C)CS(C)(=O)=O to have a lower LogP value.,CC[NH+](Cc1ccc2c(c1)CC(C)(C)O2)[C@@H](C)CS(C)(=O)=O,1.2380000000000002
+78527,Optimize the molecule C[C@H]1OCC[C@H]1C(=O)N1CCCC[C@@H]1CC(=O)[O-] to have a lower LogP value.,C[C@H]1OCC[C@H]1C(=O)N1CCCC[C@@H]1CC(=O)[O-],-0.067499999999999
+179458,Optimize the molecule COc1ccc(CC(=O)NCCOc2cccc(C)c2)cc1F to have a higher LogP value.,COc1ccc(CC(=O)NCCOc2cccc(C)c2)cc1F,2.8804200000000018
+142852,Modify the molecule COc1cc2c(cc1OC)[C@H](c1cccs1)N(C(=O)[C@H]1Cc3ccccc31)CC2 to have a higher LogP value.,COc1cc2c(cc1OC)[C@H](c1cccs1)N(C(=O)[C@H]1Cc3ccccc31)CC2,4.5793000000000035
+160501,Optimize the molecule CC(=O)N(C)[C@H](c1ccc2c(c1)OCO2)c1nnnn1-c1ccc(C)cc1 to have a higher LogP value.,CC(=O)N(C)[C@H](c1ccc2c(c1)OCO2)c1nnnn1-c1ccc(C)cc1,2.2671200000000002
+81663,Please modify the molecule CCCC[NH+](CCO)Cc1ncc(C)o1 to increase its LogP value.,CCCC[NH+](CCO)Cc1ncc(C)o1,0.16032000000000046
+145014,Please modify the molecule COc1ccc(-c2nonc2NC(=O)COc2ccc(C)c(C)c2)cc1 to increase its LogP value.,COc1ccc(-c2nonc2NC(=O)COc2ccc(C)c(C)c2)cc1,3.379540000000002
+194126,Modify the molecule CCC1(CC)[C@@H](OC)C[C@H]1[NH2+][C@@H]1CCN(Cc2ccccn2)C[C@@H]1C to decrease its LogP value.,CCC1(CC)[C@@H](OC)C[C@H]1[NH2+][C@@H]1CCN(Cc2ccccn2)C[C@@H]1C,2.4491000000000005
+248241,Modify the molecule Cc1nn(CC(=O)N(C)[C@H](C)c2ccccc2)c(C)c1S(=O)(=O)N(C)C to have a higher LogP value.,Cc1nn(CC(=O)N(C)[C@H](C)c2ccccc2)c(C)c1S(=O)(=O)N(C)C,1.9698400000000003
+62015,Modify the molecule C[C@H](C(=O)Nc1ncccn1)[NH+](C)Cc1ccccc1N1CCOCC1 to decrease its LogP value.,C[C@H](C(=O)Nc1ncccn1)[NH+](C)Cc1ccccc1N1CCOCC1,0.3551000000000015
+74562,Modify the molecule O=C(NCc1cccnc1OC1CCCC1)c1ccc2c(c1)COCO2 to have a lower LogP value.,O=C(NCc1cccnc1OC1CCCC1)c1ccc2c(c1)COCO2,3.1995000000000022
+15181,Please modify the molecule NC(=O)c1ccnc(N(CC(=O)[O-])CC(F)(F)F)c1 to increase its LogP value.,NC(=O)c1ccnc(N(CC(=O)[O-])CC(F)(F)F)c1,-0.7009000000000003
+198677,Please optimize the molecule COC(=O)c1ccccc1S(=O)(=O)Nc1cc2c(cc1Cl)OCCO2 to have a higher LogP value.,COC(=O)c1ccccc1S(=O)(=O)Nc1cc2c(cc1Cl)OCCO2,2.6986000000000008
+242873,Please modify the molecule CCn1cc(C(=O)N[C@@H]2CC3(CCCC3)Oc3ccccc32)c(C)n1 to increase its LogP value.,CCn1cc(C(=O)N[C@@H]2CC3(CCCC3)Oc3ccccc32)c(C)n1,3.777820000000003
+210741,Please optimize the molecule Cc1nn(-c2ccccc2)cc1CN1CCN(CC#N)CC1 to have a lower LogP value.,Cc1nn(-c2ccccc2)cc1CN1CCN(CC#N)CC1,1.8218999999999999
+44542,Optimize the molecule C[C@@H]1[NH2+]CC[C@@H]1C(=O)Nc1ccc(OC(F)(F)F)cc1 to have a higher LogP value.,C[C@@H]1[NH2+]CC[C@@H]1C(=O)Nc1ccc(OC(F)(F)F)cc1,1.4955
+217635,Please modify the molecule CC(=O)c1ccc(OCC(=O)Nc2ccccc2C(C)C)cc1 to increase its LogP value.,CC(=O)c1ccc(OCC(=O)Nc2ccccc2C(C)C)cc1,4.030100000000003
+53304,Please modify the molecule C[NH2+]C[C@@H](C)C(=O)Nc1ccc2c(c1)C(=O)NC2=O to decrease its LogP value.,C[NH2+]C[C@@H](C)C(=O)Nc1ccc2c(c1)C(=O)NC2=O,-0.661999999999999
+213595,Modify the molecule CC[C@@H](C)NC(=O)C(=O)Nc1ccc(S(=O)(=O)C(F)F)cc1 to increase its LogP value.,CC[C@@H](C)NC(=O)C(=O)Nc1ccc(S(=O)(=O)C(F)F)cc1,1.5361000000000002
+180477,Modify the molecule CCc1sc([C@H](C)[NH2+][C@@H](C)C2CC[NH+](C)CC2)cc1C to decrease its LogP value.,CCc1sc([C@H](C)[NH2+][C@@H](C)C2CC[NH+](C)CC2)cc1C,1.5565200000000008
+198645,Please modify the molecule O=[N+]([O-])c1ccc(F)c(NCc2ncc(-c3cccs3)o2)c1 to decrease its LogP value.,O=[N+]([O-])c1ccc(F)c(NCc2ncc(-c3cccs3)o2)c1,4.062500000000002
+108011,Modify the molecule O=C(CSc1ccccn1)N/N=C/c1cccc(I)c1 to have a lower LogP value.,O=C(CSc1ccccn1)N/N=C/c1cccc(I)c1,2.928600000000001
+129223,Please optimize the molecule C[C@H]1C[C@@H](NC(=O)N(C)CC2CC2)CC[NH+]1Cc1ccccc1 to have a lower LogP value.,C[C@H]1C[C@@H](NC(=O)N(C)CC2CC2)CC[NH+]1Cc1ccccc1,1.6738000000000002
+140271,Optimize the molecule C[C@@H](CNC(=O)c1cn(Cc2cccnc2)nn1)Cc1cccs1 to have a higher LogP value.,C[C@@H](CNC(=O)c1cn(Cc2cccnc2)nn1)Cc1cccs1,2.3915000000000006
+222049,Modify the molecule COc1ccc(NC(=O)N[C@@H]2C[C@@H]2C)cc1OCC(F)(F)F to have a lower LogP value.,COc1ccc(NC(=O)N[C@@H]2C[C@@H]2C)cc1OCC(F)(F)F,3.1662000000000017
+142403,Please optimize the molecule CC(=O)N1CC[C@H](NC(=O)Nc2cccc(CC[NH+]3CCCC3)c2)C1 to have a higher LogP value.,CC(=O)N1CC[C@H](NC(=O)Nc2cccc(CC[NH+]3CCCC3)c2)C1,0.6501000000000015
+161587,Modify the molecule CCC1CCC(C[NH2+][C@H]2CCOC3(CCSCC3)C2)CC1 to decrease its LogP value.,CCC1CCC(C[NH2+][C@H]2CCOC3(CCSCC3)C2)CC1,3.211000000000001
+117259,Optimize the molecule COCCOc1cc(C)ccc1NC(=O)[C@H]1CCOc2ccccc21 to have a higher LogP value.,COCCOc1cc(C)ccc1NC(=O)[C@H]1CCOc2ccccc21,3.5250200000000023
+25059,Modify the molecule C#CC[C@H](OC(=O)CCn1cnc2c(C)cccc2c1=O)C1CC1 to decrease its LogP value.,C#CC[C@H](OC(=O)CCn1cnc2c(C)cccc2c1=O)C1CC1,2.4401200000000003
+164968,Please modify the molecule O=C(NCc1nnc2n1CCCCC2)N[C@H]1C[C@H]2CCCc3cccc1c32 to decrease its LogP value.,O=C(NCc1nnc2n1CCCCC2)N[C@H]1C[C@H]2CCCc3cccc1c32,3.3686000000000016
+132115,Please modify the molecule Cc1ccc2nc(NC(=O)c3nc(S(C)(=O)=O)ncc3Br)sc2c1 to decrease its LogP value.,Cc1ccc2nc(NC(=O)c3nc(S(C)(=O)=O)ncc3Br)sc2c1,2.8130200000000007
+135724,Modify the molecule CCOCCCNC(=O)NCc1cc2ccccc2o1 to have a higher LogP value.,CCOCCCNC(=O)NCc1cc2ccccc2o1,2.6586000000000007
+57623,Please optimize the molecule O=C(COc1ccccc1)N/N=C(/C=C/c1ccccc1)c1ccccc1 to have a higher LogP value.,O=C(COc1ccccc1)N/N=C(/C=C/c1ccccc1)c1ccccc1,4.299300000000003
+26333,Modify the molecule CN(C)S(=O)(=O)N1CC[NH+](CCc2ccccc2C(F)(F)F)CC1 to have a higher LogP value.,CN(C)S(=O)(=O)N1CC[NH+](CCc2ccccc2C(F)(F)F)CC1,0.2548000000000028
+172382,Modify the molecule CO[C@@H](C)[C@H]([NH3+])c1ccc(F)c(F)c1 to increase its LogP value.,CO[C@@H](C)[C@H]([NH3+])c1ccc(F)c(F)c1,1.2827000000000002
+164543,Optimize the molecule N#Cc1nc(/C=C/c2cccc([N+](=O)[O-])c2)oc1N1CCN(C(=O)COc2ccccc2F)CC1 to have a lower LogP value.,N#Cc1nc(/C=C/c2cccc([N+](=O)[O-])c2)oc1N1CCN(C(=O)COc2ccccc2F)CC1,3.4915800000000026
+66137,Modify the molecule C[C@H]1C[C@H](C)CN(C(=O)NC[C@@H](c2ccccc2)N2CCOCC2)C1 to have a higher LogP value.,C[C@H]1C[C@H](C)CN(C(=O)NC[C@@H](c2ccccc2)N2CCOCC2)C1,2.7474000000000007
+91669,Optimize the molecule COc1ccc(F)c(CN2CCC[C@](O)(C[NH2+]C3(C(N)=O)CCCC3)C2=O)c1 to have a lower LogP value.,COc1ccc(F)c(CN2CCC[C@](O)(C[NH2+]C3(C(N)=O)CCCC3)C2=O)c1,0.04930000000000101
+85889,Please modify the molecule CC(C)[C@H](CCO)NC(=O)c1ccc(-n2ccnn2)cc1 to decrease its LogP value.,CC(C)[C@H](CCO)NC(=O)c1ccc(-n2ccnn2)cc1,1.4041
+159588,Please modify the molecule Cc1ccc(C)c(NC(=O)[C@H](c2ccccc2)N2CCN(C(=O)C3CC3)CC2)c1 to decrease its LogP value.,Cc1ccc(C)c(NC(=O)[C@H](c2ccccc2)N2CCN(C(=O)C3CC3)CC2)c1,3.537440000000002
+27252,Please optimize the molecule COc1cccc(C(=O)N2C[C@H](O)C[C@H]2c2cc(F)ccc2F)n1 to have a lower LogP value.,COc1cccc(C(=O)N2C[C@H](O)C[C@H]2c2cc(F)ccc2F)n1,2.3165000000000004
+155909,Modify the molecule O=C(NCc1ccccc1F)C(=O)Nc1ccccc1Br to have a higher LogP value.,O=C(NCc1ccccc1F)C(=O)Nc1ccccc1Br,2.8431000000000006
+6708,Please optimize the molecule COC(=O)C[C@@H]1CCCCN1C(=O)c1cccnc1 to have a higher LogP value.,COC(=O)C[C@@H]1CCCCN1C(=O)c1cccnc1,1.6394
+100269,Please modify the molecule O=S(=O)(/N=C1\N=c2ccccc2=[NH+][C@@H]1Nc1ccc2c(c1)OCO2)c1ccc(Cl)cc1 to increase its LogP value.,O=S(=O)(/N=C1\N=c2ccccc2=[NH+][C@@H]1Nc1ccc2c(c1)OCO2)c1ccc(Cl)cc1,0.6276999999999997
+233824,Modify the molecule COc1ccccc1[C@@H]1CC(=O)C2=C(C1)NC(C)=C(C(=O)OC[C@@H]1CCCO1)[C@@H]2c1ccccc1F to have a lower LogP value.,COc1ccccc1[C@@H]1CC(=O)C2=C(C1)NC(C)=C(C(=O)OC[C@@H]1CCCO1)[C@@H]2c1ccccc1F,4.918100000000004
+65576,Modify the molecule CCc1nc(CN2CCN(Cc3scnc3C)CC2)cs1 to have a higher LogP value.,CCc1nc(CN2CCN(Cc3scnc3C)CC2)cs1,2.788220000000001
+221994,Please modify the molecule Cc1ccc(Cl)cc1NC(=O)COC(=O)CN1C(=O)[C@H]2CCCC[C@@H]2C1=O to increase its LogP value.,Cc1ccc(Cl)cc1NC(=O)COC(=O)CN1C(=O)[C@H]2CCCC[C@@H]2C1=O,2.30532
+218853,Optimize the molecule CNC(=O)NCC(=O)N1CCC(=Cc2ccccc2)CC1 to have a lower LogP value.,CNC(=O)NCC(=O)N1CCC(=Cc2ccccc2)CC1,1.6213999999999997
+76706,Please optimize the molecule CCc1ccccc1N(CC(=O)N1CCN(C=O)CC1)S(C)(=O)=O to have a higher LogP value.,CCc1ccccc1N(CC(=O)N1CCN(C=O)CC1)S(C)(=O)=O,0.315600000000001
+67369,Modify the molecule CCNC(=S)NNC(=O)c1cn(C)nc1C to have a lower LogP value.,CCNC(=S)NNC(=O)c1cn(C)nc1C,-0.14267999999999992
+101058,Modify the molecule COc1cc(Br)c(CC(=O)NCC2CC2)cc1OC to have a lower LogP value.,COc1cc(Br)c(CC(=O)NCC2CC2)cc1OC,2.535
+167852,Modify the molecule O=C(Cn1cnc2sccc2c1=O)N1N=C2/C(=C/c3ccco3)CCC[C@H]2[C@@H]1c1ccco1 to have a higher LogP value.,O=C(Cn1cnc2sccc2c1=O)N1N=C2/C(=C/c3ccco3)CCC[C@H]2[C@@H]1c1ccco1,4.467200000000004
+138310,Modify the molecule CC(C)c1ccc2[nH+]c3c(cc2c1)CCN3 to have a lower LogP value.,CC(C)c1ccc2[nH+]c3c(cc2c1)CCN3,2.7453000000000003
+43585,Please modify the molecule C[C@@H](NC(=O)C(C)(C)C)C(=O)N1CCc2c(F)ccc(F)c2C1 to increase its LogP value.,C[C@@H](NC(=O)C(C)(C)C)C(=O)N1CCc2c(F)ccc(F)c2C1,2.4003000000000005
+61245,Modify the molecule CC[C@@H](C)NC(=O)c1snc(C(=O)NC(C)C)c1N to decrease its LogP value.,CC[C@@H](C)NC(=O)c1snc(C(=O)NC(C)C)c1N,1.3918000000000001
+20093,Optimize the molecule O=C(NCc1ccccc1F)N1CCN(S(=O)(=O)c2ccccc2F)CC1 to have a lower LogP value.,O=C(NCc1ccccc1F)N1CCN(S(=O)(=O)c2ccccc2F)CC1,2.1809000000000003
+189293,Modify the molecule NC(=O)NCC(=O)Nc1cccc(-c2ccc3c(c2)CCO3)c1 to increase its LogP value.,NC(=O)NCC(=O)Nc1cccc(-c2ccc3c(c2)CCO3)c1,1.8953
+94726,Please optimize the molecule CC(=O)Nc1ccc(CC(=O)OCc2cc(=O)n3ccc(C)cc3n2)cc1 to have a lower LogP value.,CC(=O)Nc1ccc(CC(=O)OCc2cc(=O)n3ccc(C)cc3n2)cc1,2.2472199999999996
+119851,Modify the molecule Nc1c(NCc2ccccc2)ncnc1Nc1ccccc1F to have a lower LogP value.,Nc1c(NCc2ccccc2)ncnc1Nc1ccccc1F,3.553600000000002
+36210,Optimize the molecule C[C@H]1C[C@@H](C)CN(C(=O)CN2CC[NH+](Cc3cccc(C(F)(F)F)c3)CC2)C1 to have a lower LogP value.,C[C@H]1C[C@@H](C)CN(C(=O)CN2CC[NH+](Cc3cccc(C(F)(F)F)c3)CC2)C1,1.9104000000000003
+43187,Optimize the molecule CCN(Cc1cc(=O)n(C)c(=O)n1C)[C@@H](C)c1cccc(OC)c1 to have a lower LogP value.,CCN(Cc1cc(=O)n(C)c(=O)n1C)[C@@H](C)c1cccc(OC)c1,1.6756999999999995
+38943,Please modify the molecule O=C(c1ccc(Cl)cc1F)N1CCC(CCc2ccc(O)cc2)CC1 to decrease its LogP value.,O=C(c1ccc(Cl)cc1F)N1CCC(CCc2ccc(O)cc2)CC1,4.669700000000003
+120509,Optimize the molecule FC(F)(F)c1cccc(OCCCCCS)c1 to have a lower LogP value.,FC(F)(F)c1cccc(OCCCCCS)c1,4.184300000000003
+8975,Please optimize the molecule COC(=O)c1c(NC(=S)Nc2ccc3c(c2)CCC3)sc2c1CC[C@H](C)C2 to have a higher LogP value.,COC(=O)c1c(NC(=S)Nc2ccc3c(c2)CCC3)sc2c1CC[C@H](C)C2,4.957100000000004
+12297,Please modify the molecule CN(C)C(=O)Sc1cccc(CN2C(=O)c3ccc(F)cc3C2=O)c1 to decrease its LogP value.,CN(C)C(=O)Sc1cccc(CN2C(=O)c3ccc(F)cc3C2=O)c1,3.3956000000000026
+101501,Modify the molecule Cn1c(C(=O)NCC(=O)Nc2cccc(Cl)c2)cc2occc21 to increase its LogP value.,Cn1c(C(=O)NCC(=O)Nc2cccc(Cl)c2)cc2occc21,2.7932000000000006
+8395,Optimize the molecule FC(F)(F)c1cccc(Nc2scc(-c3ccc(Cl)cc3)[n+]2CCc2ccccc2)c1 to have a higher LogP value.,FC(F)(F)c1cccc(Nc2scc(-c3ccc(Cl)cc3)[n+]2CCc2ccccc2)c1,7.361100000000005
+143872,Optimize the molecule O=C(/C=C/c1ccccc1Cl)Nc1ccc([N+](=O)[O-])cn1 to have a lower LogP value.,O=C(/C=C/c1ccccc1Cl)Nc1ccc([N+](=O)[O-])cn1,3.2951000000000015
+97860,Modify the molecule Cc1nc(-c2c[nH]c(C(=O)NCC3(c4cccc(F)c4)CCOCC3)c2)cs1 to have a higher LogP value.,Cc1nc(-c2c[nH]c(C(=O)NCC3(c4cccc(F)c4)CCOCC3)c2)cs1,4.063920000000003
+78552,Modify the molecule CCCCN(C)C(=O)C(=O)Nc1cc(C(=O)NC(C)C)ccc1Cl to have a lower LogP value.,CCCCN(C)C(=O)C(=O)Nc1cc(C(=O)NC(C)C)ccc1Cl,2.6752000000000002
+173219,Modify the molecule CCCn1/c(=N/C(=O)c2ccc[nH]c2=S)[nH]c2ccccc21 to increase its LogP value.,CCCn1/c(=N/C(=O)c2ccc[nH]c2=S)[nH]c2ccccc21,3.178090000000001
+75597,Modify the molecule Cc1ccc(NCCC(=O)c2cccs2)cc1F to increase its LogP value.,Cc1ccc(NCCC(=O)c2cccs2)cc1F,3.8805200000000024
+217173,Optimize the molecule COc1cc(Br)cc(CN2CCO[C@@H](c3nccs3)C2)c1O to have a higher LogP value.,COc1cc(Br)cc(CN2CCO[C@@H](c3nccs3)C2)c1O,3.193300000000002
+233980,Modify the molecule CC(C)[NH2+]C[C@@H](C)[C@H](C)N(C)[C@@H](C)c1ccccc1F to decrease its LogP value.,CC(C)[NH2+]C[C@@H](C)[C@H](C)N(C)[C@@H](C)c1ccccc1F,2.8149000000000006
+46384,Modify the molecule Cc1ncccc1OC1(C(=O)[O-])CCN(C(=O)c2ccc([O-])nn2)CC1 to decrease its LogP value.,Cc1ncccc1OC1(C(=O)[O-])CCN(C(=O)c2ccc([O-])nn2)CC1,-0.9426799999999995
+119964,Modify the molecule O=C(NC1CC1)c1cccnc1Oc1ccc([N-]S(=O)(=O)c2ccc(Cl)s2)cc1 to increase its LogP value.,O=C(NC1CC1)c1cccnc1Oc1ccc([N-]S(=O)(=O)c2ccc(Cl)s2)cc1,4.875100000000003
+240204,Please modify the molecule CCc1cc(N2CC[C@@H]([NH3+])C2)nc(Nc2ccccc2)n1 to increase its LogP value.,CCc1cc(N2CC[C@@H]([NH3+])C2)nc(Nc2ccccc2)n1,1.6031999999999993
+165868,Modify the molecule Nc1nnc(SCC(=O)N2CCC(Cc3ccccc3)CC2)s1 to have a lower LogP value.,Nc1nnc(SCC(=O)N2CCC(Cc3ccccc3)CC2)s1,2.6937000000000006
+140225,Please optimize the molecule CCN1CCC2=C(C1)C(=O)NC(=O)[C@@H]2C#N to have a higher LogP value.,CCN1CCC2=C(C1)C(=O)NC(=O)[C@@H]2C#N,-0.19522000000000012
+45298,Optimize the molecule Cc1cc(C)n(CC2=NN=C(C(=O)NC[C@@H]3CCCCO3)C2)n1 to have a higher LogP value.,Cc1cc(C)n(CC2=NN=C(C(=O)NC[C@@H]3CCCCO3)C2)n1,1.3859399999999993
+192809,Optimize the molecule C[C@H](NC(=O)c1ccncc1F)c1cccc(-n2cccn2)c1 to have a higher LogP value.,C[C@H](NC(=O)c1ccncc1F)c1cccc(-n2cccn2)c1,2.897400000000001
+88033,Please optimize the molecule O=C(N[C@H](N1CCOCC1)C(Cl)(Cl)Cl)c1ccccc1 to have a higher LogP value.,O=C(N[C@H](N1CCOCC1)C(Cl)(Cl)Cl)c1ccccc1,2.4449000000000005
+49898,Modify the molecule CCOc1ccc([C@H](O)C2([NH+]3CCCC3)CCCC2)cc1 to have a higher LogP value.,CCOc1ccc([C@H](O)C2([NH+]3CCCC3)CCCC2)cc1,2.110199999999999
+210283,Please optimize the molecule COc1ccccc1[C@H](C)[NH2+][C@@H]1CN(C(=O)OC(C)(C)C)C[C@@H]1OC to have a lower LogP value.,COc1ccccc1[C@H](C)[NH2+][C@@H]1CN(C(=O)OC(C)(C)C)C[C@@H]1OC,1.9538999999999997
+131485,Modify the molecule O[C@H]1CCCc2[nH]c3cc(F)c(F)c(F)c3c21 to decrease its LogP value.,O[C@H]1CCCc2[nH]c3cc(F)c(F)c(F)c3c21,2.954900000000001
+183384,Optimize the molecule C[NH+]1CCC(CCNC(=O)C(=O)Nc2ccc(F)cc2F)CC1 to have a higher LogP value.,C[NH+]1CCC(CCNC(=O)C(=O)Nc2ccc(F)cc2F)CC1,0.3342999999999998
+103722,Please optimize the molecule OCC[C@H]1CN(c2ncnc3c2CC[NH2+]CC3)CCN1Cc1ccoc1 to have a higher LogP value.,OCC[C@H]1CN(c2ncnc3c2CC[NH2+]CC3)CCN1Cc1ccoc1,-0.19519999999999738
+33930,Modify the molecule CCOC(=O)c1cnc2ccc(Cl)nc2c1Cl to decrease its LogP value.,CCOC(=O)c1cnc2ccc(Cl)nc2c1Cl,3.1133000000000015
+105853,Please modify the molecule COC[C@@H](NC(=O)Cc1c[nH]c2ccccc12)c1ccc(F)c(F)c1 to increase its LogP value.,COC[C@@H](NC(=O)Cc1c[nH]c2ccccc12)c1ccc(F)c(F)c1,3.4925000000000015
+29417,Modify the molecule CC1=C[C@@H]([C@@H]2N=N[C@H](S)N2/N=C/c2ccc(C(=O)[O-])cc2)N=N1 to increase its LogP value.,CC1=C[C@@H]([C@@H]2N=N[C@H](S)N2/N=C/c2ccc(C(=O)[O-])cc2)N=N1,1.4295
+19528,Please modify the molecule CC1=N[C@@H](CNC(=O)[C@H]2C=C(C[NH+](C)Cc3ccccc3)ON2)N=C1 to decrease its LogP value.,CC1=N[C@@H](CNC(=O)[C@H]2C=C(C[NH+](C)Cc3ccccc3)ON2)N=C1,-0.5237999999999967
+196139,Modify the molecule Cc1cc(C[NH+]2CCN(C(=O)c3oc4ccc(Cl)cc4c3C)CC2)no1 to increase its LogP value.,Cc1cc(C[NH+]2CCN(C(=O)c3oc4ccc(Cl)cc4c3C)CC2)no1,2.23194
+217273,Please modify the molecule Nn1c(SCC(=O)Nc2cc(Cl)cc(Cl)c2)nnc1C(F)(F)F to decrease its LogP value.,Nn1c(SCC(=O)Nc2cc(Cl)cc(Cl)c2)nnc1C(F)(F)F,3.048300000000001
+69070,Optimize the molecule CN(C)[C@H](CNC(=O)c1cccc(S(C)(=O)=O)c1)c1cccs1 to have a higher LogP value.,CN(C)[C@H](CNC(=O)c1cccc(S(C)(=O)=O)c1)c1cccs1,2.1842999999999995
+133791,Modify the molecule COc1cccc(NC(=O)/C(C#N)=C/c2ccc(C)o2)c1 to have a lower LogP value.,COc1cccc(NC(=O)/C(C#N)=C/c2ccc(C)o2)c1,3.1423000000000014
+247532,Please optimize the molecule N#Cc1cc(-c2ccccc2)oc1/N=C/c1ccc(Cl)cc1 to have a higher LogP value.,N#Cc1cc(-c2ccccc2)oc1/N=C/c1ccc(Cl)cc1,5.222280000000003
+67743,Modify the molecule O=C(Nc1ccccc1)c1nnc(C(=O)N2CCC[C@@H](C(=O)N3CCCC3)C2)s1 to have a lower LogP value.,O=C(Nc1ccccc1)c1nnc(C(=O)N2CCC[C@@H](C(=O)N3CCCC3)C2)s1,2.2650000000000006
+88590,Please optimize the molecule C[NH+]1CCC[C@]2(CC1)CNC(=[NH2+])N2c1ccccc1F to have a higher LogP value.,C[NH+]1CCC[C@]2(CC1)CNC(=[NH2+])N2c1ccccc1F,-1.2121999999999966
+199167,Please modify the molecule O=C1C[C@@H](c2cc([N+](=O)[O-])ccc2Cl)c2cc3c(cc2N1)OCO3 to increase its LogP value.,O=C1C[C@@H](c2cc([N+](=O)[O-])ccc2Cl)c2cc3c(cc2N1)OCO3,3.4510000000000014
+21819,Modify the molecule CCOC(=O)/C=C/c1ccc(NC(=O)N[C@@H](C)[C@H]2CCCO2)cc1 to have a higher LogP value.,CCOC(=O)/C=C/c1ccc(NC(=O)N[C@@H](C)[C@H]2CCCO2)cc1,2.951900000000001
+158646,Optimize the molecule NNC(=O)[C@@H]1CCCN(C(=O)COc2ccc(-c3ccccc3)cc2)C1 to have a lower LogP value.,NNC(=O)[C@@H]1CCCN(C(=O)COc2ccc(-c3ccccc3)cc2)C1,1.9608999999999996
+15159,Modify the molecule Cc1cccc(Nc2ncnc(N(C)C)c2[N+](=O)[O-])c1C to have a higher LogP value.,Cc1cccc(Nc2ncnc(N(C)C)c2[N+](=O)[O-])c1C,2.8112400000000006
+90965,Optimize the molecule O=C(CCNS(=O)(=O)c1ccc2ccccc2c1)Nc1ccc(F)cc1 to have a higher LogP value.,O=C(CCNS(=O)(=O)c1ccc2ccccc2c1)Nc1ccc(F)cc1,3.2860000000000014
+147707,Please optimize the molecule Cc1ccc(OC[C@@H](O)C[NH+](C)Cc2cc(C)on2)c(C)c1 to have a higher LogP value.,Cc1ccc(OC[C@@H](O)C[NH+](C)Cc2cc(C)on2)c(C)c1,1.0544600000000002
+113034,Please optimize the molecule O=C(c1cc[nH]n1)N1CCC2(CC1)c1ccccc1[C@@H]([NH+]1CCCCC1)[C@@H]2O to have a lower LogP value.,O=C(c1cc[nH]n1)N1CCC2(CC1)c1ccccc1[C@@H]([NH+]1CCCCC1)[C@@H]2O,1.0680999999999998
+163237,Please optimize the molecule Cc1nc(Br)ccc1NC(=O)N1CCN(C(=O)CO)CC1 to have a lower LogP value.,Cc1nc(Br)ccc1NC(=O)N1CCN(C(=O)CO)CC1,0.8209199999999996
+158217,Modify the molecule CC(C)C[C@@H](C[NH3+])c1nc2ccccc2n1CC(F)(F)F to decrease its LogP value.,CC(C)C[C@@H](C[NH3+])c1nc2ccccc2n1CC(F)(F)F,2.970200000000001
+60889,Optimize the molecule C[C@H]1C[C@H]([NH3+])CN(Cc2cc(F)ccc2Br)C1 to have a higher LogP value.,C[C@H]1C[C@H]([NH3+])CN(Cc2cc(F)ccc2Br)C1,2.0404999999999998
+30041,Please optimize the molecule Cc1ccc([C@](C)([NH3+])CCC(C)C)cc1F to have a lower LogP value.,Cc1ccc([C@](C)([NH3+])CCC(C)C)cc1F,3.027420000000001
+164422,Modify the molecule COc1cc2c(cc1OC)[C@@H](CC(=O)[O-])N(C(=O)Nc1ccc(Cl)cc1)CC2 to decrease its LogP value.,COc1cc2c(cc1OC)[C@@H](CC(=O)[O-])N(C(=O)Nc1ccc(Cl)cc1)CC2,2.6285000000000007
+44048,Optimize the molecule CC[C@H](C)N(C)C(=O)c1c(O)cc(F)cc1F to have a lower LogP value.,CC[C@H](C)N(C)C(=O)c1c(O)cc(F)cc1F,2.5409000000000006
+222453,Optimize the molecule C[C@H](CCc1cccn1C)NC(=O)N[C@H]1CCC[C@@H]1CO to have a higher LogP value.,C[C@H](CCc1cccn1C)NC(=O)N[C@H]1CCC[C@@H]1CO,1.8063999999999996
+8378,Optimize the molecule C=CCNC(=O)N(Cc1ccsc1)C1CC1 to have a higher LogP value.,C=CCNC(=O)N(Cc1ccsc1)C1CC1,2.608100000000001
+178808,Please optimize the molecule Cc1ccc(OCC(=O)N(C)CCS(C)(=O)=O)cc1C to have a lower LogP value.,Cc1ccc(OCC(=O)N(C)CCS(C)(=O)=O)cc1C,1.18524
+158187,Modify the molecule Cc1cc(CNC(=O)c2cc(C)sc2NC(=O)C(C)(C)C)[nH]n1 to increase its LogP value.,Cc1cc(CNC(=O)c2cc(C)sc2NC(=O)C(C)(C)C)[nH]n1,3.0026400000000013
+34624,Please modify the molecule CC(C)(O)CNC(=O)[C@H]1C=C[C@@H]([NH3+])C1 to decrease its LogP value.,CC(C)(O)CNC(=O)[C@H]1C=C[C@@H]([NH3+])C1,-0.9398999999999988
+133352,Optimize the molecule CSCCOC(=O)[C@@H](C)Oc1cccc(Cl)c1 to have a lower LogP value.,CSCCOC(=O)[C@@H](C)Oc1cccc(Cl)c1,3.0135000000000014
+91038,Modify the molecule CCCn1nnnc1COc1ccnc2cc(OC)ccc12 to have a lower LogP value.,CCCn1nnnc1COc1ccnc2cc(OC)ccc12,2.2188999999999997
+196513,Optimize the molecule C[C@H](CCO)NC(=O)N[C@H](c1cccnc1)c1cccc(C(F)(F)F)c1 to have a lower LogP value.,C[C@H](CCO)NC(=O)N[C@H](c1cccnc1)c1cccc(C(F)(F)F)c1,3.259900000000002
+109637,Modify the molecule O=S(=O)(NCC1CCN(c2nsc3ccccc23)CC1)c1ccccc1F to have a lower LogP value.,O=S(=O)(NCC1CCN(c2nsc3ccccc23)CC1)c1ccccc1F,3.6303000000000027
+54994,Modify the molecule C[C@H](NC(=O)N(C)CCc1ccc(F)cc1)c1cccc(-n2cccn2)c1 to decrease its LogP value.,C[C@H](NC(=O)N(C)CCc1ccc(F)cc1)c1cccc(-n2cccn2)c1,3.956500000000003
+80570,Please optimize the molecule C=CCn1c(SCC(=O)c2ccc(C#N)cc2)nc2ccccc2c1=O to have a higher LogP value.,C=CCn1c(SCC(=O)c2ccc(C#N)cc2)nc2ccccc2c1=O,3.4291800000000023
+97472,Modify the molecule O=S1(=O)CC[C@@](O)([C@@H]2CCOC3(CCCC3)C2)C1 to have a lower LogP value.,O=S1(=O)CC[C@@](O)([C@@H]2CCOC3(CCCC3)C2)C1,1.2753999999999999
+24052,Modify the molecule CC[C@@](C)([C@H]([NH3+])CCC1CC1)N1CCOCC1 to decrease its LogP value.,CC[C@@](C)([C@H]([NH3+])CCC1CC1)N1CCOCC1,1.2880000000000007
+231616,Please optimize the molecule N#C/C(=C/c1cccn1-c1ccc(C(=O)[O-])cc1)C(=O)Nc1ccc(O)cc1 to have a higher LogP value.,N#C/C(=C/c1cccn1-c1ccc(C(=O)[O-])cc1)C(=O)Nc1ccc(O)cc1,2.0920799999999993
+70154,Optimize the molecule C[C@H](NC(=O)Nc1ccc(N(C)C)cc1)c1cc2ccccc2o1 to have a lower LogP value.,C[C@H](NC(=O)Nc1ccc(N(C)C)cc1)c1cc2ccccc2o1,4.381500000000003
+39885,Please optimize the molecule C=CCOc1c(Br)cc(/C=C(/C#N)C(=O)N(C)C)cc1I to have a lower LogP value.,C=CCOc1c(Br)cc(/C=C(/C#N)C(=O)N(C)C)cc1I,3.613680000000003
+155074,Modify the molecule O=C(c1cc(-c2ccccc2)on1)N1CC[C@H](c2ccccn2)C1 to increase its LogP value.,O=C(c1cc(-c2ccccc2)on1)N1CC[C@H](c2ccccn2)C1,3.3663000000000016
+223963,Modify the molecule COc1ccc(N[C@@H](c2ccc(Cl)cc2)c2nnc(-c3ccccc3)o2)cc1OC to have a lower LogP value.,COc1ccc(N[C@@H](c2ccc(Cl)cc2)c2nnc(-c3ccccc3)o2)cc1OC,5.608700000000005
+241363,Please modify the molecule C[C@@H](C(=O)Nc1ccccc1C#N)[NH+]1CCN(c2cccc(Cl)c2)CC1 to decrease its LogP value.,C[C@@H](C(=O)Nc1ccccc1C#N)[NH+]1CCN(c2cccc(Cl)c2)CC1,1.9437799999999996
+84372,Modify the molecule O=C(CCc1nc(-c2ccc(Cl)cc2)no1)Nc1cccc(Oc2cnccn2)c1 to increase its LogP value.,O=C(CCc1nc(-c2ccc(Cl)cc2)no1)Nc1cccc(Oc2cnccn2)c1,4.543600000000003
+881,Modify the molecule COc1c(C)cnc(CNC(=O)Nc2ccc(N(C)C)cc2)c1C to decrease its LogP value.,COc1c(C)cnc(CNC(=O)Nc2ccc(N(C)C)cc2)c1C,3.0947400000000016
+230264,Modify the molecule CS(=O)(=O)Cc1ccc(C(=O)Nc2nc[nH]n2)cc1 to decrease its LogP value.,CS(=O)(=O)Cc1ccc(C(=O)Nc2nc[nH]n2)cc1,0.6015999999999998
+192739,Please optimize the molecule Cc1ccc(F)cc1C(=O)NCCCCN1C[C@@H](C)O[C@H](C)C1 to have a lower LogP value.,Cc1ccc(F)cc1C(=O)NCCCCN1C[C@@H](C)O[C@H](C)C1,2.7533200000000013
+72883,Please modify the molecule Cc1n[nH]c(N/N=C\c2ccccc2)nc1=O to decrease its LogP value.,Cc1n[nH]c(N/N=C\c2ccccc2)nc1=O,0.9193199999999999
+49621,Optimize the molecule O=C(c1ccc2c(c1)OCCO2)C1CC[NH+](CCCO)CC1 to have a higher LogP value.,O=C(c1ccc2c(c1)OCCO2)C1CC[NH+](CCCO)CC1,0.3178000000000006
+157859,Modify the molecule Cc1ccccc1NCN1C(=O)S/C(=C\c2ccc(N(C)C)cc2)C1=O to decrease its LogP value.,Cc1ccccc1NCN1C(=O)S/C(=C\c2ccc(N(C)C)cc2)C1=O,4.166920000000003
+247108,Optimize the molecule COc1ccc([C@H]2c3c(C)n[nH]c3Nc3[nH]c(=O)[nH]c(=O)c32)c(OC)c1 to have a lower LogP value.,COc1ccc([C@H]2c3c(C)n[nH]c3Nc3[nH]c(=O)[nH]c(=O)c32)c(OC)c1,1.3491199999999999
+199870,Modify the molecule NC1=[NH+]C[C@@H]([C@@H]2CCCOC2)N1c1ccc(F)cc1 to have a higher LogP value.,NC1=[NH+]C[C@@H]([C@@H]2CCCOC2)N1c1ccc(F)cc1,-0.16379999999999995
+88345,Please modify the molecule Cc1ccc(NC(=O)/C=C/C2CC2)cc1NC(=O)c1ccncc1 to decrease its LogP value.,Cc1ccc(NC(=O)/C=C/C2CC2)cc1NC(=O)c1ccncc1,3.5470200000000016
+71097,Please modify the molecule CN1C(=O)Cc2cc([C@H]([NH3+])c3ccccc3F)ccc21 to increase its LogP value.,CN1C(=O)Cc2cc([C@H]([NH3+])c3ccccc3F)ccc21,1.6758999999999997
+195839,Optimize the molecule CS[C@H](C)C(=O)NCc1csc(Br)c1 to have a higher LogP value.,CS[C@H](C)C(=O)NCc1csc(Br)c1,2.878300000000001
+165348,Please optimize the molecule CC(CO)(CO)C[C@H]1Cc2ccccc2O1 to have a lower LogP value.,CC(CO)(CO)C[C@H]1Cc2ccccc2O1,1.3711
+244438,Please optimize the molecule CC[C@](C)([NH2+]CCC(=O)Nc1ccccc1)C(=O)[O-] to have a lower LogP value.,CC[C@](C)([NH2+]CCC(=O)Nc1ccccc1)C(=O)[O-],-0.502799999999999
+146843,Please optimize the molecule Cc1cccc(NC(=O)Cn2nc(-c3ccccc3)nc2-c2ccccc2)c1 to have a higher LogP value.,Cc1cccc(NC(=O)Cn2nc(-c3ccccc3)nc2-c2ccccc2)c1,4.559220000000003
+204296,Modify the molecule COC(=O)c1ccc(CSc2nnc(N)n2C(C)C)o1 to decrease its LogP value.,COC(=O)c1ccc(CSc2nnc(N)n2C(C)C)o1,2.1130999999999998
+1765,Modify the molecule Cc1cc(OC(=O)Cc2cccs2)cc2c1C(=O)/C(=C/c1ccccn1)O2 to increase its LogP value.,Cc1cc(OC(=O)Cc2cccs2)cc2c1C(=O)/C(=C/c1ccccn1)O2,4.2158200000000035
+150897,Optimize the molecule Cc1nc(Cc2ccccc2)sc1[C@@H](C)[NH2+]C[C@H]1CC[C@H](C(N)=O)O1 to have a lower LogP value.,Cc1nc(Cc2ccccc2)sc1[C@@H](C)[NH2+]C[C@H]1CC[C@H](C(N)=O)O1,1.69962
+245815,Optimize the molecule Nc1cncc(-c2nc3ccc(F)cc3s2)c1 to have a higher LogP value.,Nc1cncc(-c2nc3ccc(F)cc3s2)c1,3.079600000000001
+161103,Modify the molecule NC(=O)c1ccc(Cn2cc(C(F)(F)F)ccc2=O)c([N+](=O)[O-])c1 to decrease its LogP value.,NC(=O)c1ccc(Cn2cc(C(F)(F)F)ccc2=O)c([N+](=O)[O-])c1,1.9224999999999999
+226564,Please modify the molecule O=C(Cn1ncn2nccc2c1=O)N1CCC[C@@H](n2cncn2)C1 to decrease its LogP value.,O=C(Cn1ncn2nccc2c1=O)N1CCC[C@@H](n2cncn2)C1,-0.6537999999999993
+26242,Modify the molecule Cc1nc(COC(=O)[C@@H]2CSCN2C(=O)CC(C)(C)C)sc1C to increase its LogP value.,Cc1nc(COC(=O)[C@@H]2CSCN2C(=O)CC(C)(C)C)sc1C,3.1408400000000016
+85738,Modify the molecule C[C@H]1C(=O)N[C@@H](C(C)(C)C)C(=O)N1CC1C(C)(C)C1(C)C to decrease its LogP value.,C[C@H]1C(=O)N[C@@H](C(C)(C)C)C(=O)N1CC1C(C)(C)C1(C)C,2.4302
+231335,Modify the molecule CN(Cc1cnn(C)c1)C(=O)CN1CCN(C(=O)NC2CCCCC2)CC1 to decrease its LogP value.,CN(Cc1cnn(C)c1)C(=O)CN1CCN(C(=O)NC2CCCCC2)CC1,1.0384000000000013
+69009,Modify the molecule COCCN(C(=O)c1cccc2c1OCCO2)c1ccncc1 to decrease its LogP value.,COCCN(C(=O)c1cccc2c1OCCO2)c1ccncc1,2.146000000000001
+119855,Please optimize the molecule COc1ccc(CC[C@]2(C)NC(=O)N(Cc3ncc(-c4ccccc4)o3)C2=O)cc1 to have a higher LogP value.,COc1ccc(CC[C@]2(C)NC(=O)N(Cc3ncc(-c4ccccc4)o3)C2=O)cc1,3.7935000000000025
+139649,Please optimize the molecule Cc1ccnc2c1nc([C@@H](C)Cl)n2Cc1ccccc1 to have a higher LogP value.,Cc1ccnc2c1nc([C@@H](C)Cl)n2Cc1ccccc1,4.0878200000000025
+195495,Modify the molecule O=C1NC(=O)/C(=C/c2ccc(F)cc2F)S1 to have a lower LogP value.,O=C1NC(=O)/C(=C/c2ccc(F)cc2F)S1,2.2887000000000004
+194472,Optimize the molecule O=c1c2ccccc2nnn1COc1cccc(Cl)c1 to have a lower LogP value.,O=c1c2ccccc2nnn1COc1cccc(Cl)c1,2.4814
+29598,Modify the molecule CN(CC(=O)NC[C@H](O)c1c(F)cccc1F)C(=O)c1cccs1 to increase its LogP value.,CN(CC(=O)NC[C@H](O)c1c(F)cccc1F)C(=O)c1cccs1,1.9480999999999997
+50005,Optimize the molecule C=CCNC(=O)[C@@H](C)OC(=O)c1ccc2c(c1)OCCO2 to have a lower LogP value.,C=CCNC(=O)[C@@H](C)OC(=O)c1ccc2c(c1)OCCO2,1.3052999999999997
+7996,Optimize the molecule CNC(=O)C1=NN=C2NC(=O)C[C@H]([C@@H]3C=NN=C3C3CCCCC3)[C@H]21 to have a lower LogP value.,CNC(=O)C1=NN=C2NC(=O)C[C@H]([C@@H]3C=NN=C3C3CCCCC3)[C@H]21,0.8896999999999995
+4530,Modify the molecule O=C([O-])[C@@H]1C[C@@H](O)CN1C(=O)c1ccccc1 to decrease its LogP value.,O=C([O-])[C@@H]1C[C@@H](O)CN1C(=O)c1ccccc1,-0.9880999999999995
+143242,Please modify the molecule Cc1ccc([C@H]2[C@H](C(=O)N3CCN(c4ccc(Cl)cc4)CC3)OCC(=O)N2C)cc1 to increase its LogP value.,Cc1ccc([C@H]2[C@H](C(=O)N3CCN(c4ccc(Cl)cc4)CC3)OCC(=O)N2C)cc1,2.895520000000001
+135875,Modify the molecule CCNC(=O)NNC(=O)C[NH+]1CCC[C@@H]1C to have a higher LogP value.,CCNC(=O)NNC(=O)C[NH+]1CCC[C@@H]1C,-1.5960999999999972
+144562,Please optimize the molecule CCCC(=O)Oc1ccc([C@H]2NC(=O)c3ccccc3O2)cc1 to have a lower LogP value.,CCCC(=O)Oc1ccc([C@H]2NC(=O)c3ccccc3O2)cc1,3.2131000000000016
+130304,Modify the molecule CCn1nc(C)c(C[NH+]2CCC[C@@H](CNC(=O)c3ccccc3)C2)c1C to have a higher LogP value.,CCn1nc(C)c(C[NH+]2CCC[C@@H](CNC(=O)c3ccccc3)C2)c1C,1.7447400000000004
+232758,Optimize the molecule COc1cc2c(cc1OC)CN(CN1C(=O)N[C@]3(CCCC[C@@H]3C)C1=O)CC2 to have a lower LogP value.,COc1cc2c(cc1OC)CN(CN1C(=O)N[C@]3(CCCC[C@@H]3C)C1=O)CC2,2.5201000000000002
+133673,Optimize the molecule O=C(NCCC1CCN(c2cc[nH+]cc2)CC1)NC[C@]1(O)CCSC1 to have a higher LogP value.,O=C(NCCC1CCN(c2cc[nH+]cc2)CC1)NC[C@]1(O)CCSC1,1.2744
+224283,Please optimize the molecule C[C@H](NC(=O)Cc1ccc(S(=O)(=O)N2CCCCC2)cc1)c1ccccc1 to have a higher LogP value.,C[C@H](NC(=O)Cc1ccc(S(=O)(=O)N2CCCCC2)cc1)c1ccccc1,3.2811000000000012
+197292,Please modify the molecule O=c1cn[nH]c(N/N=C/c2ccc(O)cc2)n1 to decrease its LogP value.,O=c1cn[nH]c(N/N=C/c2ccc(O)cc2)n1,0.3164999999999997
+161643,Optimize the molecule C[C@@H]1C[C@H]1c1ccc(CN(Cc2ccco2)C(=O)c2cccc([N+](=O)[O-])c2)o1 to have a lower LogP value.,C[C@@H]1C[C@H]1c1ccc(CN(Cc2ccco2)C(=O)c2cccc([N+](=O)[O-])c2)o1,4.746800000000005
+9167,Modify the molecule CCn1cc([C@H]2C[C@@H](C(=O)Nc3ccc(Cl)cc3Cl)N(C)S(=O)(=O)N2)c(C)n1 to increase its LogP value.,CCn1cc([C@H]2C[C@@H](C(=O)Nc3ccc(Cl)cc3Cl)N(C)S(=O)(=O)N2)c(C)n1,2.7365200000000005
+162557,Modify the molecule Cc1ccc(C(=O)c2ccccc2C(=O)NCc2nnc3n2CCCCC3)cc1 to have a higher LogP value.,Cc1ccc(C(=O)c2ccccc2C(=O)NCc2nnc3n2CCCCC3)cc1,3.4739200000000023
+18518,Optimize the molecule COc1cc([C@H](C)NC(=O)N2CC[C@H](C)C2)cc(OC)c1OC to have a higher LogP value.,COc1cc([C@H](C)NC(=O)N2CC[C@H](C)C2)cc(OC)c1OC,2.8248000000000015
+10631,Please modify the molecule Cc1noc(C)c1CN1CCC[NH2+][C@H](C(C)C)C1 to decrease its LogP value.,Cc1noc(C)c1CN1CCC[NH2+][C@H](C(C)C)C1,1.0851400000000004
+61220,Modify the molecule O=c1ccc2c([nH]1)CCC[C@H]2[NH2+]C[C@@H]1C[C@H]1c1ccc(Cl)cc1Cl to decrease its LogP value.,O=c1ccc2c([nH]1)CCC[C@H]2[NH2+]C[C@@H]1C[C@H]1c1ccc(Cl)cc1Cl,3.4262000000000015
+125301,Modify the molecule Cc1cc(/C=C2\C(=O)N(C)C(=O)N(c3ccccc3)C2=O)c(C)n1-c1cccc(Cl)c1 to decrease its LogP value.,Cc1cc(/C=C2\C(=O)N(C)C(=O)N(c3ccccc3)C2=O)c(C)n1-c1cccc(Cl)c1,4.756140000000005
+130766,Optimize the molecule C[C@@H](CNC(=O)Nc1cncc2ccccc12)[S@](C)=O to have a lower LogP value.,C[C@@H](CNC(=O)Nc1cncc2ccccc12)[S@](C)=O,2.1233000000000004
+202463,Modify the molecule COc1ccc(C[NH+]2CCN(c3ccc(Cl)cc3N)CC2)cc1 to decrease its LogP value.,COc1ccc(C[NH+]2CCN(c3ccc(Cl)cc3N)CC2)cc1,1.8359
+5875,Modify the molecule CCc1noc(CC)c1CNC(=O)[C@@H]1Cc2cccc(F)c2O1 to have a higher LogP value.,CCc1noc(CC)c1CNC(=O)[C@@H]1Cc2cccc(F)c2O1,2.5584000000000007
+193685,Modify the molecule Cc1cccc(-n2nnnc2SCC(=O)Nc2cccc(Cl)c2C)c1 to increase its LogP value.,Cc1cccc(-n2nnnc2SCC(=O)Nc2cccc(Cl)c2C)c1,3.6633400000000025
+143578,Please optimize the molecule CCc1ccccc1Nc1nc(N)nc(CN(C)C[C@H]2COc3ccccc3O2)n1 to have a higher LogP value.,CCc1ccccc1Nc1nc(N)nc(CN(C)C[C@H]2COc3ccccc3O2)n1,3.031600000000001
+161979,Modify the molecule C[C@H](Oc1ccc(Br)cc1)C(=O)Nc1cccc(S(=O)(=O)N(C)C)c1 to increase its LogP value.,C[C@H](Oc1ccc(Br)cc1)C(=O)Nc1cccc(S(=O)(=O)N(C)C)c1,3.1054000000000013
+30814,Please optimize the molecule COc1ccccc1[C@@H]1CCCN1C(=O)NCCN1CCOCC1 to have a higher LogP value.,COc1ccccc1[C@@H]1CCCN1C(=O)NCCN1CCOCC1,1.8739
+124124,Optimize the molecule CC(C)CC(=O)Nc1cccc(CNC(=O)N2CCOCC[C@H]2C)c1 to have a lower LogP value.,CC(C)CC(=O)Nc1cccc(CNC(=O)N2CCOCC[C@H]2C)c1,2.991600000000002
+193238,Please modify the molecule C[C@@H](NC(=O)CCn1cnc2sccc2c1=O)c1ccc(Cl)cc1 to decrease its LogP value.,C[C@@H](NC(=O)CCn1cnc2sccc2c1=O)c1ccc(Cl)cc1,3.3789000000000016
+51535,Modify the molecule COc1ccc(Cl)cc1-n1nnc(C(=O)NCc2ccccc2Cl)c1C to have a lower LogP value.,COc1ccc(Cl)cc1-n1nnc(C(=O)NCc2ccccc2Cl)c1C,3.8211200000000023
+153527,Modify the molecule CCOC(=O)c1c(NC(=O)Cn2nc(C)cc2C)sc(C)c1C to decrease its LogP value.,CCOC(=O)c1c(NC(=O)Cn2nc(C)cc2C)sc(C)c1C,2.9936800000000012
+121371,Please modify the molecule Cn1nc(C(=O)Cl)cc1-c1ccccc1 to decrease its LogP value.,Cn1nc(C(=O)Cl)cc1-c1ccccc1,2.4661
+7217,Please modify the molecule C[C@@H](NC(=O)N(C)C[C@@H]1CCOC1)C(C)(C)C[NH+](C)C to increase its LogP value.,C[C@@H](NC(=O)N(C)C[C@@H]1CCOC1)C(C)(C)C[NH+](C)C,0.22350000000000292
+25991,Modify the molecule CCNC(=O)c1ccc(CNC(=O)N[C@@H]2CCCC2(C)C)cc1 to have a higher LogP value.,CCNC(=O)c1ccc(CNC(=O)N[C@@H]2CCCC2(C)C)cc1,2.8142000000000014
+226530,Modify the molecule Cc1ccc[nH+]c1NCCNC(=O)C[C@@H]1C(=O)NCC[NH+]1C1CCCC1 to have a higher LogP value.,Cc1ccc[nH+]c1NCCNC(=O)C[C@@H]1C(=O)NCC[NH+]1C1CCCC1,-0.9467799999999962
+107557,Modify the molecule CC[NH2+][C@@H](c1ccc(OC)c(Br)c1)[C@@]1(C)CCCO1 to have a higher LogP value.,CC[NH2+][C@@H](c1ccc(OC)c(Br)c1)[C@@]1(C)CCCO1,2.651200000000001
+226383,Modify the molecule C[C@@H](CNC(=O)c1cccc(NC(=O)C2CC2)c1)Oc1ccc(F)cc1 to have a lower LogP value.,C[C@@H](CNC(=O)c1cccc(NC(=O)C2CC2)c1)Oc1ccc(F)cc1,3.371500000000002
+224885,Please optimize the molecule CC[C@@](C)(Nc1ccccc1Br)C(=O)[O-] to have a lower LogP value.,CC[C@@](C)(Nc1ccccc1Br)C(=O)[O-],1.7795999999999996
+220382,Modify the molecule COc1ccc(C(=O)N(C)Cc2ccc(OC(F)F)cc2)cc1[N+](=O)[O-] to have a lower LogP value.,COc1ccc(C(=O)N(C)Cc2ccc(OC(F)F)cc2)cc1[N+](=O)[O-],3.477000000000002
+196350,Please modify the molecule c1ccc([C@@H](NC[C@H]2C[NH+]3CCN2CC3)C2CC2)cc1 to decrease its LogP value.,c1ccc([C@@H](NC[C@H]2C[NH+]3CCN2CC3)C2CC2)cc1,0.31000000000000094
+114659,Please modify the molecule O=C(NC(=S)Nc1ccc2oc(-c3ccccc3F)nc2c1)c1cccc(Cl)c1 to increase its LogP value.,O=C(NC(=S)Nc1ccc2oc(-c3ccccc3F)nc2c1)c1cccc(Cl)c1,5.414100000000002
+224724,Modify the molecule CC(C)NS(=O)(=O)c1ccc(NC(=O)C2=Cc3ccccc3OC2)cc1 to have a higher LogP value.,CC(C)NS(=O)(=O)c1ccc(NC(=O)C2=Cc3ccccc3OC2)cc1,2.7878000000000016
+160485,Please modify the molecule COc1cc(CNc2ccc(N3CCCC3=O)cn2)ccc1F to increase its LogP value.,COc1cc(CNc2ccc(N3CCCC3=O)cn2)ccc1F,2.9682000000000013
+69645,Please modify the molecule CCCC[NH+](CC)Cc1ccc2c(c1)COC2 to decrease its LogP value.,CCCC[NH+](CC)Cc1ccc2c(c1)COC2,1.9217000000000002
+123516,Modify the molecule C=CCN(C(=O)c1ccc2ccccc2n1)c1nc2c(s1)CCCC2 to increase its LogP value.,C=CCN(C(=O)c1ccc2ccccc2n1)c1nc2c(s1)CCCC2,4.402900000000003
+159539,Modify the molecule CCn1nnc(NCc2ccc(-c3ccc(C)c(Cl)c3)o2)n1 to have a lower LogP value.,CCn1nnc(NCc2ccc(-c3ccc(C)c(Cl)c3)o2)n1,3.5269200000000023
+74325,Please optimize the molecule Brc1cnc(Sc2nc(Cc3cccs3)n[nH]2)nc1 to have a lower LogP value.,Brc1cnc(Sc2nc(Cc3cccs3)n[nH]2)nc1,3.160700000000001
+115463,Please modify the molecule CCCCn1nnnc1Cn1cnc2sc(-c3ccccc3)cc2c1=O to decrease its LogP value.,CCCCn1nnnc1Cn1cnc2sc(-c3ccccc3)cc2c1=O,2.959900000000001
+91136,Optimize the molecule Cc1cccc(NC(=O)N[C@H]2CCC3(C2)OCCO3)c1Cl to have a higher LogP value.,Cc1cccc(NC(=O)N[C@H]2CCC3(C2)OCCO3)c1Cl,3.065520000000001
+109539,Modify the molecule CC[C@H](NC(=O)c1cc(CC(C)C)n[nH]1)c1c(C)nn(C)c1C to increase its LogP value.,CC[C@H](NC(=O)c1cc(CC(C)C)n[nH]1)c1c(C)nn(C)c1C,2.839640000000001
+80996,Modify the molecule Cc1ccn(C)c(=O)c1NC(=O)C(=O)NC[C@H](CC(C)C)[NH+](C)C to decrease its LogP value.,Cc1ccn(C)c(=O)c1NC(=O)C(=O)NC[C@H](CC(C)C)[NH+](C)C,-0.6923799999999967
+224908,Please modify the molecule CN1C(=O)C[C@@H](NC(=O)C(=O)Nc2ccccc2)[C@@H]1c1ccc(Cl)cc1 to decrease its LogP value.,CN1C(=O)C[C@@H](NC(=O)C(=O)Nc2ccccc2)[C@@H]1c1ccc(Cl)cc1,2.3667
+71819,Optimize the molecule N#Cc1ccc(C[NH+]2C[C@H]3CCCC[C@@H]3C2)o1 to have a higher LogP value.,N#Cc1ccc(C[NH+]2C[C@H]3CCCC[C@@H]3C2)o1,1.3561799999999995
+202528,Modify the molecule Cc1cc([C@H](O)[C@H](C)C(C)C)c(F)cc1F to have a higher LogP value.,Cc1cc([C@H](O)[C@H](C)C(C)C)c(F)cc1F,3.598720000000003
+84920,Modify the molecule C=CCOc1cccc([C@@H]2SCC(O)=Nc3n[nH]cc32)c1 to decrease its LogP value.,C=CCOc1cccc([C@@H]2SCC(O)=Nc3n[nH]cc32)c1,3.3987000000000016
+144355,Please modify the molecule CCNC(=O)[C@@H](C)NC(=O)c1ccc([N+](=O)[O-])c(C)c1 to increase its LogP value.,CCNC(=O)[C@@H](C)NC(=O)c1ccc([N+](=O)[O-])c(C)c1,1.1576199999999999
+206725,Please optimize the molecule CC[C@@H]1CCC[C@H](NC(=O)N2CCCN(c3ncccc3C#N)CC2)C1 to have a lower LogP value.,CC[C@@H]1CCC[C@H](NC(=O)N2CCCN(c3ncccc3C#N)CC2)C1,3.1437800000000014
+63889,Please optimize the molecule C#CCOc1c(C(F)(F)F)nn(-c2ccccc2)c1C to have a higher LogP value.,C#CCOc1c(C(F)(F)F)nn(-c2ccccc2)c1C,3.211520000000001
+13362,Please optimize the molecule CC1(C)CC(=O)C2=C(C1)NC1=C(C(=O)CC(C)(C)C1)C2c1ccc(F)cc1 to have a higher LogP value.,CC1(C)CC(=O)C2=C(C1)NC1=C(C(=O)CC(C)(C)C1)C2c1ccc(F)cc1,4.798900000000004
+127737,Optimize the molecule C[C@H]1CCc2ccccc2N1C(=O)COc1ccc(-c2nnco2)cc1 to have a lower LogP value.,C[C@H]1CCc2ccccc2N1C(=O)COc1ccc(-c2nnco2)cc1,3.4833000000000025
+55211,Modify the molecule O=C(COC(=O)c1cccc2c1C(=O)c1ccccc1C2=O)N[C@H]1CCS(=O)(=O)C1 to increase its LogP value.,O=C(COC(=O)c1cccc2c1C(=O)c1ccccc1C2=O)N[C@H]1CCS(=O)(=O)C1,0.9220999999999999
+37333,Modify the molecule Cc1ccc(S(C)(=O)=O)cc1C(=O)N1CC[C@@H](C)[C@H](O)C1 to have a higher LogP value.,Cc1ccc(S(C)(=O)=O)cc1C(=O)N1CC[C@@H](C)[C@H](O)C1,1.24142
+154215,Modify the molecule CSc1ccc([C@H]2CC(=O)NC3=C2C(=O)C[C@@H](c2ccc(C)cc2)C3)cc1 to increase its LogP value.,CSc1ccc([C@H]2CC(=O)NC3=C2C(=O)C[C@@H](c2ccc(C)cc2)C3)cc1,4.721220000000004
+239981,Please optimize the molecule C[C@H](Sc1nncn1C)C(=O)Nc1ccccc1SC(F)F to have a higher LogP value.,C[C@H](Sc1nncn1C)C(=O)Nc1ccccc1SC(F)F,3.249100000000001
+81758,Please modify the molecule C#Cc1cc(F)c(NC(=O)NC[C@H]2CC[NH+](CCC)C2)c(F)c1 to increase its LogP value.,C#Cc1cc(F)c(NC(=O)NC[C@H]2CC[NH+](CCC)C2)c(F)c1,1.3823999999999992
+153813,Optimize the molecule CN(CCCC(=O)N1CCC[C@H]1c1ccc[nH]1)S(=O)(=O)c1ccc(F)cc1 to have a lower LogP value.,CN(CCCC(=O)N1CCC[C@H]1c1ccc[nH]1)S(=O)(=O)c1ccc(F)cc1,2.9182000000000006
+207419,Optimize the molecule C[C@@H](NC(=O)c1cccs1)C(=O)NCCc1cc(F)cc(F)c1 to have a higher LogP value.,C[C@@H](NC(=O)c1cccs1)C(=O)NCCc1cc(F)cc(F)c1,2.5035000000000007
+24189,Modify the molecule O=c1[nH]nc(CC2CC[NH+](CCC(F)(F)F)CC2)n1-c1ccccc1 to decrease its LogP value.,O=c1[nH]nc(CC2CC[NH+](CCC(F)(F)F)CC2)n1-c1ccccc1,1.3503999999999994
+179527,Please optimize the molecule CCC[C@H]1CN(C(=O)[C@H](Cc2ccccc2)NC(=O)c2ccco2)CCO1 to have a lower LogP value.,CCC[C@H]1CN(C(=O)[C@H](Cc2ccccc2)NC(=O)c2ccco2)CCO1,2.648200000000001
+50680,Modify the molecule Cc1cccc([C@@H](CNS(=O)(=O)c2ccc(C)cc2F)N2CCOCC2)c1 to have a higher LogP value.,Cc1cccc([C@@H](CNS(=O)(=O)c2ccc(C)cc2F)N2CCOCC2)c1,2.794340000000001
+129694,Modify the molecule Cc1cc(NC(=O)[C@@H]2COCC(=O)N2Cc2ccccc2)no1 to decrease its LogP value.,Cc1cc(NC(=O)[C@@H]2COCC(=O)N2Cc2ccccc2)no1,1.3491199999999997
+198704,Please optimize the molecule C[NH+](C)[C@H](CNC(=O)N[C@@H](c1nccs1)C1CC1)c1cccs1 to have a lower LogP value.,C[NH+](C)[C@H](CNC(=O)N[C@@H](c1nccs1)C1CC1)c1cccs1,1.8407
+242439,Modify the molecule COC[C@@H](NC(=O)c1cc(C2CC2)nc2c1c(C)nn2C)C(N)=O to have a lower LogP value.,COC[C@@H](NC(=O)c1cc(C2CC2)nc2c1c(C)nn2C)C(N)=O,0.38422000000000034
+186726,Please modify the molecule C[C@@H](CO)NC(=O)C(=O)Nc1ccccc1COc1ccccc1 to decrease its LogP value.,C[C@@H](CO)NC(=O)C(=O)Nc1ccccc1COc1ccccc1,1.7010999999999994
+230191,Please optimize the molecule COc1ccc(NC(=O)c2ccc(OC(=S)N3CCC(C)CC3)cc2)cc1 to have a lower LogP value.,COc1ccc(NC(=O)c2ccc(OC(=S)N3CCC(C)CC3)cc2)cc1,4.343100000000003
+83079,Please optimize the molecule O=C(CCc1ccccc1)N(Cc1cccnc1)c1nc2ccc(Br)cc2s1 to have a lower LogP value.,O=C(CCc1ccccc1)N(Cc1cccnc1)c1nc2ccc(Br)cc2s1,5.619800000000004
+44670,Modify the molecule COc1ccc(N2CCN(CC(=O)NC3CCCC3)C2=O)cc1OC to increase its LogP value.,COc1ccc(N2CCN(CC(=O)NC3CCCC3)C2=O)cc1OC,2.0046
+132742,Please modify the molecule Cc1ccc(S(=O)(=O)N2CCN(C(=O)c3cccc(F)c3)CC2)cc1 to increase its LogP value.,Cc1ccc(S(=O)(=O)N2CCN(C(=O)c3cccc(F)c3)CC2)cc1,2.2808200000000003
+7968,Modify the molecule C[C@@H]1CCC[C@@H](C)N1S(=O)(=O)c1ccc(Br)cc1 to have a lower LogP value.,C[C@@H]1CCC[C@@H](C)N1S(=O)(=O)c1ccc(Br)cc1,3.4007000000000023
+161727,Please modify the molecule COc1ccc(NC(=O)[C@@H](C)S(=O)(=O)c2ccc(Br)cc2)cc1 to increase its LogP value.,COc1ccc(NC(=O)[C@@H](C)S(=O)(=O)c2ccc(Br)cc2)cc1,3.258600000000002
+31324,Modify the molecule C[C@@H]([NH2+][C@H](C)c1c[nH]c2ccc([N+](=O)[O-])cc12)C(=O)N1CCOCC1 to increase its LogP value.,C[C@@H]([NH2+][C@H](C)c1c[nH]c2ccc([N+](=O)[O-])cc12)C(=O)N1CCOCC1,0.9477999999999993
+123794,Modify the molecule O=C(NCC#CCOc1ccccc1F)c1ccccc1[N+](=O)[O-] to increase its LogP value.,O=C(NCC#CCOc1ccccc1F)c1ccccc1[N+](=O)[O-],2.546100000000001
+201514,Modify the molecule CS(=O)(=O)CC[NH+](Cc1ccc(N2CCCCC2)cc1)C1CC1 to increase its LogP value.,CS(=O)(=O)CC[NH+](Cc1ccc(N2CCCCC2)cc1)C1CC1,1.2688000000000013
+203178,Modify the molecule Cc1ccc(C2=CC(=O)N(CC(=O)Nc3ccccc3F)c3ccccc3N2)cc1 to decrease its LogP value.,Cc1ccc(C2=CC(=O)N(CC(=O)Nc3ccccc3F)c3ccccc3N2)cc1,4.572420000000003
+43888,Please modify the molecule CN(C)c1cc(C(=O)N2CCC[C@H](n3cccn3)C2)ccn1 to increase its LogP value.,CN(C)c1cc(C(=O)N2CCC[C@H](n3cccn3)C2)ccn1,1.8214
+155333,Please modify the molecule CN(CCN(C)c1ccccc1)C(=O)C(=O)Nc1ccc2c(c1)COC2 to increase its LogP value.,CN(CCN(C)c1ccccc1)C(=O)C(=O)Nc1ccc2c(c1)COC2,2.2500999999999998
+221693,Modify the molecule COc1cccc([C@@H](CO)NC(=O)N[C@H](c2ccc(F)cc2)C2CC2)c1 to have a higher LogP value.,COc1cccc([C@@H](CO)NC(=O)N[C@H](c2ccc(F)cc2)C2CC2)c1,3.318200000000002
+137239,Optimize the molecule O=C(C[C@@H]1CSc2nc3c(cnn3-c3ccc(Cl)cc3)c(=O)n21)NC[C@@H]1CCCO1 to have a lower LogP value.,O=C(C[C@@H]1CSc2nc3c(cnn3-c3ccc(Cl)cc3)c(=O)n21)NC[C@@H]1CCCO1,2.567700000000001
+247232,Modify the molecule O=C(CN1C(=O)N[C@H](CCc2ccccc2)C1=O)Nc1cccc(Br)c1 to have a lower LogP value.,O=C(CN1C(=O)N[C@H](CCc2ccccc2)C1=O)Nc1cccc(Br)c1,2.940800000000001
+125339,Modify the molecule Cc1ncccc1O[C@H]1C[C@@H]([NH3+])C12CCCC2 to decrease its LogP value.,Cc1ncccc1O[C@H]1C[C@@H]([NH3+])C12CCCC2,1.7120199999999997
+101976,Modify the molecule Cc1nc(-c2cccc(NC(=O)C(=O)N[C@@H]3C[C@H]3C3CCCCC3)c2)n[nH]1 to have a lower LogP value.,Cc1nc(-c2cccc(NC(=O)C(=O)N[C@@H]3C[C@H]3C3CCCCC3)c2)n[nH]1,2.8036200000000004
+62618,Modify the molecule Cc1cc(NC(=O)N(CC2CC2)C2CCCCC2)ccc1N(C)C to decrease its LogP value.,Cc1cc(NC(=O)N(CC2CC2)C2CCCCC2)ccc1N(C)C,4.6376200000000045
+76568,Please modify the molecule Cc1ccc(CCC(=O)Nc2cc(S(C)(=O)=O)ccc2Cl)cc1 to increase its LogP value.,Cc1ccc(CCC(=O)Nc2cc(S(C)(=O)=O)ccc2Cl)cc1,3.6232200000000017
+190222,Please modify the molecule Cc1nc(C[C@@H](O)c2cc(Cl)ccc2Br)sc1C to decrease its LogP value.,Cc1nc(C[C@@H](O)c2cc(Cl)ccc2Br)sc1C,4.451940000000001
+124554,Optimize the molecule CCC[NH+]1CCC(O)(C[C@@H]2C[C@H]3CC[C@@H]2C3)CC1 to have a lower LogP value.,CCC[NH+]1CCC(O)(C[C@@H]2C[C@H]3CC[C@@H]2C3)CC1,1.6324999999999994
+137420,Please modify the molecule Cc1cccc([C@@H]2[C@@H]3[NH+]=c4ccccc4=C3CCN2Cc2ccccn2)c1 to increase its LogP value.,Cc1cccc([C@@H]2[C@@H]3[NH+]=c4ccccc4=C3CCN2Cc2ccccn2)c1,1.2703199999999997
+231478,Please optimize the molecule CC(C)(C)c1nnc(CNc2ccc(F)cc2OCC2CC2)o1 to have a higher LogP value.,CC(C)(C)c1nnc(CNc2ccc(F)cc2OCC2CC2)o1,3.9071000000000025
+195464,Modify the molecule COc1ccc(OC)c(-c2cc(C(=O)N3CCC[C@@H](OC)C3)no2)c1 to increase its LogP value.,COc1ccc(OC)c(-c2cc(C(=O)N3CCC[C@@H](OC)C3)no2)c1,2.609800000000001
+106854,Modify the molecule NC(=O)[C@@H]1CN(C(=O)NCc2[nH+]ccn2CCCc2ccccc2)CCO1 to have a higher LogP value.,NC(=O)[C@@H]1CN(C(=O)NCc2[nH+]ccn2CCCc2ccccc2)CCO1,0.33070000000000066
+124705,Modify the molecule Cc1ccc(NC(=O)Cn2nc(-c3ccc(Br)cc3)ccc2=O)cc1F to decrease its LogP value.,Cc1ccc(NC(=O)Cn2nc(-c3ccc(Br)cc3)ccc2=O)cc1F,3.7590200000000014
+178437,Modify the molecule Cc1ccc2cc([C@H](c3nnnn3C(C)(C)C)[NH+]3CCN(C(=O)c4ccco4)CC3)c(=O)[nH]c2c1 to have a lower LogP value.,Cc1ccc2cc([C@H](c3nnnn3C(C)(C)C)[NH+]3CCN(C(=O)c4ccco4)CC3)c(=O)[nH]c2c1,1.3013200000000005
+103586,Modify the molecule COc1cc(CN2CCS(=O)(=O)[C@@H](C)[C@H]2C)ccc1OCC(F)(F)F to increase its LogP value.,COc1cc(CN2CCS(=O)(=O)[C@@H](C)[C@H]2C)ccc1OCC(F)(F)F,2.643700000000001
+56892,Please modify the molecule CNC(=O)COc1ccccc1CN1CCO[C@@H](C#N)C1 to decrease its LogP value.,CNC(=O)COc1ccccc1CN1CCO[C@@H](C#N)C1,0.5357799999999995
+125352,Please optimize the molecule Cc1cccc2sc(NC(=O)CCNS(=O)(=O)c3ccc([N+](=O)[O-])cc3)nc12 to have a lower LogP value.,Cc1cccc2sc(NC(=O)CCNS(=O)(=O)c3ccc([N+](=O)[O-])cc3)nc12,2.8200200000000004
+242574,Please modify the molecule CC(C)[C@@H](C[NH3+])C(=O)N1[C@@H](C(=O)[O-])CC[C@H]2CCCC[C@H]21 to decrease its LogP value.,CC(C)[C@@H](C[NH3+])C(=O)N1[C@@H](C(=O)[O-])CC[C@H]2CCCC[C@H]21,-0.19979999999999865
+74071,Modify the molecule Cc1cccc([C@H](C)[NH2+][C@@H](C)Cn2ncc3ccccc3c2=O)c1C to decrease its LogP value.,Cc1cccc([C@H](C)[NH2+][C@@H](C)Cn2ncc3ccccc3c2=O)c1C,2.726440000000001
+103389,Modify the molecule CC(=O)c1ccc(NC(=O)[C@H]2CCCN(S(C)(=O)=O)C2)cc1C to increase its LogP value.,CC(=O)c1ccc(NC(=O)[C@H]2CCCN(S(C)(=O)=O)C2)cc1C,1.8077200000000002
+66215,Modify the molecule Cc1nc(-c2nnc(NC(=O)c3ccc(S(=O)(=O)N4CCC[C@H](C)C4)cc3)o2)cs1 to decrease its LogP value.,Cc1nc(-c2nnc(NC(=O)c3ccc(S(=O)(=O)N4CCC[C@H](C)C4)cc3)o2)cs1,3.1744200000000022
+154895,Optimize the molecule CCc1c(C)nc([C@H]2CN(CC)CCO2)nc1NC to have a higher LogP value.,CCc1c(C)nc([C@H]2CN(CC)CCO2)nc1NC,1.7823199999999997
+100945,Modify the molecule CN1C(=O)/C(=C\c2cccc(OC(=O)c3cc([N+](=O)[O-])cc([N+](=O)[O-])c3)c2)SC1=S to have a higher LogP value.,CN1C(=O)/C(=C\c2cccc(OC(=O)c3cc([N+](=O)[O-])cc([N+](=O)[O-])c3)c2)SC1=S,3.553200000000002
+191590,Modify the molecule CCc1ccc([C@@H](O)c2cc3[nH]c(=O)[nH]c3cc2Br)o1 to have a higher LogP value.,CCc1ccc([C@@H](O)c2cc3[nH]c(=O)[nH]c3cc2Br)o1,2.8558000000000003
+233611,Please optimize the molecule [NH3+][C@H](c1cccc(F)c1)[C@@H]1CCc2cccnc21 to have a lower LogP value.,[NH3+][C@H](c1cccc(F)c1)[C@@H]1CCc2cccnc21,2.2337
+160705,Modify the molecule CN(Cc1ccc(Cl)nc1)C(=O)c1cccn1Cc1ccccc1 to have a lower LogP value.,CN(Cc1ccc(Cl)nc1)C(=O)c1cccn1Cc1ccccc1,3.857000000000003
+99189,Optimize the molecule CCCNC(=O)[C@@H](C)NC(=O)c1ccc(-c2ccc3c(c2)OCCO3)s1 to have a lower LogP value.,CCCNC(=O)[C@@H](C)NC(=O)c1ccc(-c2ccc3c(c2)OCCO3)s1,2.830800000000001
+149202,Modify the molecule Cc1nnc(SCc2nc(-c3cccs3)n[nH]2)n1[C@@H]1CCC[C@H](C)C1 to decrease its LogP value.,Cc1nnc(SCc2nc(-c3cccs3)n[nH]2)n1[C@@H]1CCC[C@H](C)C1,4.476620000000003
+127868,Please optimize the molecule O=C(Nc1ccc(Cl)c(S(=O)(=O)N2CCOCC2)c1)c1cn2ccccc2n1 to have a lower LogP value.,O=C(Nc1ccc(Cl)c(S(=O)(=O)N2CCOCC2)c1)c1cn2ccccc2n1,2.2609000000000004
+209888,Optimize the molecule COc1ccc(CNC(=O)C2CCN(c3ncccc3-c3nc(-c4cccc(F)c4)no3)CC2)cc1 to have a lower LogP value.,COc1ccc(CNC(=O)C2CCN(c3ncccc3-c3nc(-c4cccc(F)c4)no3)CC2)cc1,4.479100000000003
+135512,Please optimize the molecule Cn1cc(C(=O)NCc2cccnc2-n2cncn2)c(C(C)(C)C)n1 to have a lower LogP value.,Cn1cc(C(=O)NCc2cccnc2-n2cncn2)c(C(C)(C)C)n1,1.6233000000000002
+29076,Optimize the molecule C[C@H]1CCC[C@H](NS(=O)(=O)Cc2cccc(N)c2)[C@@H]1C to have a lower LogP value.,C[C@H]1CCC[C@H](NS(=O)(=O)Cc2cccc(N)c2)[C@@H]1C,2.512900000000001
+42561,Optimize the molecule CC(C)c1ccccc1NC(=O)CCc1ccc2c(c1)OCCO2 to have a higher LogP value.,CC(C)c1ccccc1NC(=O)CCc1ccc2c(c1)OCCO2,4.1525000000000025
+150120,Please optimize the molecule CC(C)C(=O)N[C@H]1CCC[NH+](Cc2ccc(N3CCOCC3)cc2)C1 to have a higher LogP value.,CC(C)C(=O)N[C@H]1CCC[NH+](Cc2ccc(N3CCOCC3)cc2)C1,0.842700000000002
+201799,Please modify the molecule Nc1ccccc1C(=O)N1CCC(c2nnc(-c3ccccc3)o2)CC1 to increase its LogP value.,Nc1ccccc1C(=O)N1CCC(c2nnc(-c3ccccc3)o2)CC1,3.3386000000000022
+201510,Please modify the molecule O[C@H](c1ccc(Cl)s1)[C@H]1CCc2ccccc2C1 to increase its LogP value.,O[C@H](c1ccc(Cl)s1)[C@H]1CCc2ccccc2C1,4.240000000000003
+220360,Modify the molecule O=C(NCC[NH+]1CCC(O)CC1)c1ccc([C@H]2CCC[NH2+]C2)cc1 to have a lower LogP value.,O=C(NCC[NH+]1CCC(O)CC1)c1ccc([C@H]2CCC[NH2+]C2)cc1,-1.1031999999999957
+36964,Optimize the molecule COc1ccc(CN[C@H](C(N)=O)C(C)(C)C)c(Br)c1OC to have a lower LogP value.,COc1ccc(CN[C@H](C(N)=O)C(C)(C)C)c(Br)c1OC,2.4558999999999997
+142875,Please optimize the molecule C[C@@H](NC(=O)N[C@H]1CCC[C@H](C2CC2)C1)c1ccc(-c2cncnc2)cc1 to have a higher LogP value.,C[C@@H](NC(=O)N[C@H]1CCC[C@H](C2CC2)C1)c1ccc(-c2cncnc2)cc1,4.472600000000004
+118208,Optimize the molecule C[C@@H](NC(=O)CCn1ccc2c(Br)cccc21)c1ccccc1 to have a lower LogP value.,C[C@@H](NC(=O)CCn1ccc2c(Br)cccc21)c1ccccc1,4.671300000000003
+72080,Modify the molecule [NH3+]C1CCN(c2nc3ccsc3c(=O)n2Cc2ccc(F)cc2)CC1 to have a lower LogP value.,[NH3+]C1CCN(c2nc3ccsc3c(=O)n2Cc2ccc(F)cc2)CC1,1.8561
+117868,Modify the molecule C[NH2+]Cc1ccccc1OCc1cccc(C)c1 to decrease its LogP value.,C[NH2+]Cc1ccccc1OCc1cccc(C)c1,2.26722
+34176,Please optimize the molecule O=C(Nc1ccc(F)cc1)C1CCN(C(=O)Nc2ccc(Cl)cc2)CC1 to have a lower LogP value.,O=C(Nc1ccc(F)cc1)C1CCN(C(=O)Nc2ccc(Cl)cc2)CC1,4.3617000000000035
+246037,Please optimize the molecule CS(=O)(=O)c1ccc(-n2c(N)nc3cnccc32)cc1 to have a higher LogP value.,CS(=O)(=O)c1ccc(-n2c(N)nc3cnccc32)cc1,1.4062
+46036,Modify the molecule CN1C(=O)c2sccc2N2[C@@H](CCCC(=O)NCCc3c[nH]c4ccccc34)NN[C@@H]12 to increase its LogP value.,CN1C(=O)c2sccc2N2[C@@H](CCCC(=O)NCCc3c[nH]c4ccccc34)NN[C@@H]12,2.3681
+143505,Modify the molecule CC1(C)CN(C(=O)c2ccc(CSc3ncn[nH]3)cc2)CCS1 to have a lower LogP value.,CC1(C)CN(C(=O)c2ccc(CSc3ncn[nH]3)cc2)CCS1,3.0646000000000013
+75333,Please modify the molecule CCN(C(=O)c1csc(-c2cccs2)n1)c1cccc(F)c1 to increase its LogP value.,CCN(C(=O)c1csc(-c2cccs2)n1)c1cccc(F)c1,4.677400000000003
+141853,Modify the molecule O=C(CCS(=O)(=O)C1CCCC1)Nc1cccc(-n2cnnn2)c1 to decrease its LogP value.,O=C(CCS(=O)(=O)C1CCCC1)Nc1cccc(-n2cnnn2)c1,1.3482999999999998
+54693,Modify the molecule CC[C@H](C(=O)NCCc1n[nH]c(=O)[nH]1)c1cccc(C(F)(F)F)c1 to have a lower LogP value.,CC[C@H](C(=O)NCCc1n[nH]c(=O)[nH]1)c1cccc(C(F)(F)F)c1,1.9692999999999998
+229034,Modify the molecule Cc1nc2ncnn2c(NCC2CCN(C(=O)c3ccccc3)CC2)c1C to have a higher LogP value.,Cc1nc2ncnn2c(NCC2CCN(C(=O)c3ccccc3)CC2)c1C,2.705440000000001
+123413,Modify the molecule C[C@@H]1C[C@H](Nc2cc(Cl)nc(N)n2)C(=O)N1c1ccccc1 to decrease its LogP value.,C[C@@H]1C[C@H](Nc2cc(Cl)nc(N)n2)C(=O)N1c1ccccc1,2.3181000000000003
+85156,Optimize the molecule CC(C)Oc1ccc([C@H](C)Nc2c(C#N)c(=O)n(C)c(=O)n2C)cc1 to have a higher LogP value.,CC(C)Oc1ccc([C@H](C)Nc2c(C#N)c(=O)n(C)c(=O)n2C)cc1,1.9159799999999996
+180873,Optimize the molecule Cc1cccc(C)c1NC(=O)CN1CC[NH+](Cc2cccc(Cl)c2)CC1 to have a higher LogP value.,Cc1cccc(C)c1NC(=O)CN1CC[NH+](Cc2cccc(Cl)c2)CC1,2.2960400000000005
+76247,Please modify the molecule COc1ccc(CCN2C(=O)/C(=C/c3ccc(Br)cc3)SC2=S)cc1OC to increase its LogP value.,COc1ccc(CCN2C(=O)/C(=C/c3ccc(Br)cc3)SC2=S)cc1OC,4.910200000000004
+190428,Please optimize the molecule C[C@@H](Oc1ccc(Cl)cc1)C(=O)NC1CCC(O)CC1 to have a higher LogP value.,C[C@@H](Oc1ccc(Cl)cc1)C(=O)NC1CCC(O)CC1,2.527
+181699,Please optimize the molecule CC(C)[C@@H](O)CCNC(=O)c1ccc([S@@](=O)C(C)C)cc1 to have a lower LogP value.,CC(C)[C@@H](O)CCNC(=O)c1ccc([S@@](=O)C(C)C)cc1,2.3394000000000004
+222880,Optimize the molecule CC/[NH+]=C(/NC[C@@H]1CC=CCC1)N1CCC(OCC)CC1 to have a higher LogP value.,CC/[NH+]=C(/NC[C@@H]1CC=CCC1)N1CCC(OCC)CC1,0.8897000000000004
+70421,Modify the molecule COc1ccc(C)cc1S(=O)(=O)NCCc1c[nH]c2ccccc12 to have a higher LogP value.,COc1ccc(C)cc1S(=O)(=O)NCCc1c[nH]c2ccccc12,3.0059200000000006
+233909,Optimize the molecule Cc1ccc(S(=O)(=O)/N=C(\[O-])N(Cc2cccc(Br)c2)C[C@H]2CCCO2)cc1 to have a lower LogP value.,Cc1ccc(S(=O)(=O)/N=C(\[O-])N(Cc2cccc(Br)c2)C[C@H]2CCCO2)cc1,2.843720000000001
+172835,Please optimize the molecule CSC1(C[NH2+][C@H](C)C(C)(C)C)CCOCC1 to have a higher LogP value.,CSC1(C[NH2+][C@H](C)C(C)(C)C)CCOCC1,1.8965999999999994
+183395,Optimize the molecule CCC[C@H]1C[C@H]1NC(=O)c1ccc(-n2cncn2)c(C)c1 to have a lower LogP value.,CCC[C@H]1C[C@H]1NC(=O)c1ccc(-n2cncn2)c(C)c1,2.4941200000000006
+56670,Modify the molecule C[C@@](O)(CNC(=O)c1ccccc1Nc1ccccc1)CN1CCOCC1 to have a lower LogP value.,C[C@@](O)(CNC(=O)c1ccccc1Nc1ccccc1)CN1CCOCC1,2.2432000000000007
+184686,Modify the molecule CCn1/c(=N/C(=O)CC2(O)CCCC2)[nH]c2cc(Br)ccc21 to decrease its LogP value.,CCn1/c(=N/C(=O)CC2(O)CCCC2)[nH]c2cc(Br)ccc21,2.8743000000000007
+194244,Modify the molecule C[C@@H]1CN(CC2CCCC2)C(C)(C)CO1 to have a higher LogP value.,C[C@@H]1CN(CC2CCCC2)C(C)(C)CO1,2.6759000000000013
+81988,Modify the molecule Cc1ccc(C(=O)C2C(C)(C)C2(C)C)c(C)c1 to decrease its LogP value.,Cc1ccc(C(=O)C2C(C)(C)C2(C)C)c(C)c1,4.168340000000003
+72638,Please modify the molecule c1ccc2c(c1)[nH]c1c(NC[C@@H]3CCCO3)ncnc12 to decrease its LogP value.,c1ccc2c(c1)[nH]c1c(NC[C@@H]3CCCO3)ncnc12,2.702
+249137,Please modify the molecule COc1ccc(OC)c2[nH]c(=O)c(CCNC(=O)c3ccc(Br)cc3)cc12 to increase its LogP value.,COc1ccc(OC)c2[nH]c(=O)c(CCNC(=O)c3ccc(Br)cc3)cc12,3.2803000000000013
+134472,Please optimize the molecule Cc1ccccc1CS[C@@H]1CC[C@@]([NH3+])(C(N)=O)C1 to have a lower LogP value.,Cc1ccccc1CS[C@@H]1CC[C@@]([NH3+])(C(N)=O)C1,1.2467199999999996
+196868,Please optimize the molecule O=C(Cc1ccc[nH]1)NCc1[nH+]ccn1CCc1ccccc1 to have a lower LogP value.,O=C(Cc1ccc[nH]1)NCc1[nH+]ccn1CCc1ccccc1,1.731899999999999
+109482,Please optimize the molecule Fc1cccc([C@@H]2CN(Cc3ccccc3N3CCOCC3)CCO2)c1 to have a lower LogP value.,Fc1cccc([C@@H]2CN(Cc3ccccc3N3CCOCC3)CCO2)c1,3.235800000000002
+167676,Please modify the molecule CC(C)NC(=O)Nc1cccc(C(=O)N2CCCCC[C@H]2[C@H]2CCCCC2=O)c1 to decrease its LogP value.,CC(C)NC(=O)Nc1cccc(C(=O)N2CCCCC[C@H]2[C@H]2CCCCC2=O)c1,4.360600000000004
+166583,Please optimize the molecule CC(C)(C)c1ccc([C@H](O)COc2ccc(N)cc2)cc1 to have a lower LogP value.,CC(C)(C)c1ccc([C@H](O)COc2ccc(N)cc2)cc1,3.678700000000002
+125214,Optimize the molecule C[NH+]1CCC[C@@H](C(=O)NCC(C)(C)Cc2ccccc2)C1 to have a higher LogP value.,C[NH+]1CCC[C@@H](C(=O)NCC(C)(C)Cc2ccccc2)C1,1.2962000000000007
+150533,Please optimize the molecule Cc1csc(/N=C2/S/C(=C3\C(=O)Nc4ccccc43)C(=O)N2C)n1 to have a higher LogP value.,Cc1csc(/N=C2/S/C(=C3\C(=O)Nc4ccccc43)C(=O)N2C)n1,3.007620000000002
+17166,Modify the molecule Cc1nc(C(=O)N2CCc3sccc3[C@@H]2c2cccs2)nn1-c1ccc(F)cc1 to increase its LogP value.,Cc1nc(C(=O)N2CCc3sccc3[C@@H]2c2cccs2)nn1-c1ccc(F)cc1,4.625720000000003
+207512,Optimize the molecule CC(C)CN(C(=O)CN1CCO[C@@H](c2ccc(F)cc2)C1)C1CC1 to have a lower LogP value.,CC(C)CN(C(=O)CN1CCO[C@@H](c2ccc(F)cc2)C1)C1CC1,2.846000000000001
+163779,Optimize the molecule CC[C@H](NC(=O)N1CCCC1(C)C)c1cccc([N+](=O)[O-])c1 to have a lower LogP value.,CC[C@H](NC(=O)N1CCCC1(C)C)c1cccc([N+](=O)[O-])c1,3.629900000000003
+55006,Please optimize the molecule C[S@](=O)c1cccc(NC(=O)NCCC[NH2+]C2CCCCC2)c1 to have a lower LogP value.,C[S@](=O)c1cccc(NC(=O)NCCC[NH2+]C2CCCCC2)c1,1.8316999999999997
+139705,Please modify the molecule Cc1ccc(S(=O)(=O)O[C@@H]2[C@@H]([O-])[C@@H]([NH2+][C@@H](C)c3ccccc3)[C@H]3CO[C@@H]2O3)cc1 to increase its LogP value.,Cc1ccc(S(=O)(=O)O[C@@H]2[C@@H]([O-])[C@@H]([NH2+][C@@H](C)c3ccccc3)[C@H]3CO[C@@H]2O3)cc1,0.24612000000000234
+188050,Modify the molecule CCC[NH2+][C@@H](CC)c1cncc(Br)c1 to increase its LogP value.,CCC[NH2+][C@@H](CC)c1cncc(Br)c1,2.2686
+79815,Please modify the molecule Cc1cc(/C=N/N=C2\C(=O)Nc3ccccc32)c(C)n1CC(C)C to decrease its LogP value.,Cc1cc(/C=N/N=C2\C(=O)Nc3ccccc32)c(C)n1CC(C)C,3.536240000000002
+36551,Please optimize the molecule CCCNC(=S)NNC(=O)c1cc(C)oc1C to have a higher LogP value.,CCCNC(=S)NNC(=O)c1cc(C)oc1C,1.4153399999999998
+210393,Please modify the molecule CC(C)(C)c1ccc(NC(=O)CN2C(=O)N[C@@](C)(c3ccccc3)C2=O)cc1 to decrease its LogP value.,CC(C)(C)c1ccc(NC(=O)CN2C(=O)N[C@@](C)(c3ccccc3)C2=O)cc1,3.389800000000002
+205794,Modify the molecule COc1ccc(N2C(=O)CCCC2=O)cc1S(=O)(=O)Nc1ccc(N2CC[NH+](C)CC2)cc1 to increase its LogP value.,COc1ccc(N2C(=O)CCCC2=O)cc1S(=O)(=O)Nc1ccc(N2CC[NH+](C)CC2)cc1,0.8742000000000019
+208743,Please optimize the molecule CCCC[C@@H](C(=O)[O-])[C@](O)(CC)c1ccc(Cl)cc1 to have a higher LogP value.,CCCC[C@@H](C(=O)[O-])[C@](O)(CC)c1ccc(Cl)cc1,2.493900000000001
+235629,Modify the molecule O=C(CC[C@H]1CCCO1)NCc1cccc(N2CCOC2=O)c1 to have a lower LogP value.,O=C(CC[C@H]1CCCO1)NCc1cccc(N2CCOC2=O)c1,2.2186000000000003
+158925,Modify the molecule COc1coc(C(=O)Nc2ccc(NC(C)=O)cc2)cc1=O to decrease its LogP value.,COc1coc(C(=O)Nc2ccc(NC(C)=O)cc2)cc1=O,1.8590999999999998
+53851,Modify the molecule CC(C)n1ccc2ccc(C(=O)NCc3nnc4ccccn34)cc21 to have a higher LogP value.,CC(C)n1ccc2ccc(C(=O)NCc3nnc4ccccn34)cc21,3.1949000000000014
+169197,Please optimize the molecule C[C@H](N[C@H]1CCCC[C@@H]1[C@@H]1CCCC[NH2+]1)c1ccccc1 to have a higher LogP value.,C[C@H](N[C@H]1CCCC[C@@H]1[C@@H]1CCCC[NH2+]1)c1ccccc1,3.0119000000000007
+88302,Modify the molecule CCC(=O)NC(=S)Nc1ccccc1I to decrease its LogP value.,CCC(=O)NC(=S)Nc1ccccc1I,2.5142000000000007
+120878,Please modify the molecule CCN(CC)C(=O)[C@@H]1CCC[NH+]1Cc1n[nH]c(=O)[nH]1 to increase its LogP value.,CCN(CC)C(=O)[C@@H]1CCC[NH+]1Cc1n[nH]c(=O)[nH]1,-1.4862999999999966
+59725,Please optimize the molecule COc1ccc(NC(=O)c2ccc(C)[nH]c2=O)cc1OCC(F)(F)F to have a lower LogP value.,COc1ccc(NC(=O)c2ccc(C)[nH]c2=O)cc1OCC(F)(F)F,2.885320000000001
+248456,Optimize the molecule CC(C)(C)[C@@H]([NH3+])CCc1cc(F)ccc1Br to have a lower LogP value.,CC(C)(C)[C@@H]([NH3+])CCc1cc(F)ccc1Br,3.1774000000000013
+230526,Please modify the molecule CC(=O)c1ccc2ccccc2c1OCc1ccccc1C#N to decrease its LogP value.,CC(=O)c1ccc2ccccc2c1OCc1ccccc1C#N,4.4930800000000035
+225324,Please modify the molecule Cc1cc2occ(CC(=O)O[C@H]3CCCCNC3=O)c2cc1C to increase its LogP value.,Cc1cc2occ(CC(=O)O[C@H]3CCCCNC3=O)c2cc1C,2.8040400000000005
+139720,Please optimize the molecule Cc1cc(C(=O)N[C@H](C(=O)[O-])c2c(C)n[nH]c2C)c2ccc(C)c(C)c2n1 to have a lower LogP value.,Cc1cc(C(=O)N[C@H](C(=O)[O-])c2c(C)n[nH]c2C)c2ccc(C)c(C)c2n1,1.7209999999999999
+135347,Modify the molecule Cc1ccccc1-n1nnnc1SCC(=O)c1c(N)n(C)c(=O)n(C)c1=O to increase its LogP value.,Cc1ccccc1-n1nnnc1SCC(=O)c1c(N)n(C)c(=O)n(C)c1=O,-0.07468000000000008
+88876,Modify the molecule CCNc1ncc(CN2C(=O)CN(C)C2=O)s1 to decrease its LogP value.,CCNc1ncc(CN2C(=O)CN(C)C2=O)s1,0.9689000000000001
+116281,Optimize the molecule CN(c1cccc(C#N)c1)[C@@H]1CCOC2(CCCCC2)C1 to have a higher LogP value.,CN(c1cccc(C#N)c1)[C@@H]1CCOC2(CCCCC2)C1,3.876380000000003
+172898,Modify the molecule O=C1CN(CC(=O)Nc2nc3ccccc3s2)CCN1 to have a lower LogP value.,O=C1CN(CC(=O)Nc2nc3ccccc3s2)CCN1,0.6665999999999994
+47145,Modify the molecule CC[C@@H]1CN(C(C)=O)CC[C@@H]1[NH2+]Cc1ccc(Cl)c(F)c1 to have a lower LogP value.,CC[C@@H]1CN(C(C)=O)CC[C@@H]1[NH2+]Cc1ccc(Cl)c(F)c1,2.1895000000000007
+139342,Please optimize the molecule C[C@@H]1CC[C@H](C#N)[C@H](n2cnc3ccccc32)C1 to have a higher LogP value.,C[C@@H]1CC[C@H](C#N)[C@H](n2cnc3ccccc32)C1,3.537180000000002
+37569,Modify the molecule CC[C@H](C)C(=O)NC(C)(C)c1ccc(F)cc1Cl to decrease its LogP value.,CC[C@H](C)C(=O)NC(C)(C)c1ccc(F)cc1Cl,3.8765000000000027
+233286,Please modify the molecule Cn1ncnc1CCNC1=NS(=O)(=O)c2ccccc21 to increase its LogP value.,Cn1ncnc1CCNC1=NS(=O)(=O)c2ccccc21,0.09630000000000033
+45251,Optimize the molecule CCC1([C@@H](O)c2cc(OC)c(OC)cc2Cl)CCCC1 to have a higher LogP value.,CCC1([C@@H](O)c2cc(OC)c(OC)cc2Cl)CCCC1,4.361000000000003
+223942,Please optimize the molecule Cc1csc2c(NNc3c4ccccc4nc4ccccc34)ncnc12 to have a lower LogP value.,Cc1csc2c(NNc3c4ccccc4nc4ccccc34)ncnc12,5.140120000000003
+37936,Please optimize the molecule COCCCNC(=O)[C@@H](C)S(=O)(=O)c1ccc2c(c1)OCCO2 to have a higher LogP value.,COCCCNC(=O)[C@@H](C)S(=O)(=O)c1ccc2c(c1)OCCO2,0.7726999999999999
+90099,Please modify the molecule COc1cc(NCCC[C@H](C)[NH3+])c2ncccc2c1 to decrease its LogP value.,COc1cc(NCCC[C@H](C)[NH3+])c2ncccc2c1,2.065899999999999
+178302,Modify the molecule CCOCCCC(=O)N1c2ccc(N)cc2C[C@H]1C to have a lower LogP value.,CCOCCCC(=O)N1c2ccc(N)cc2C[C@H]1C,2.3631
+17076,Modify the molecule C[NH+]1CCN(C(=O)c2cc(-c3ccc4c(c3)OCO4)nc3ccccc23)CC1 to have a higher LogP value.,C[NH+]1CCN(C(=O)c2cc(-c3ccc4c(c3)OCO4)nc3ccccc23)CC1,1.6010000000000002
+181219,Modify the molecule CC[C@]1(c2ccccc2)NC(=O)N(Cc2cc(=O)n(C)c(=O)n2C)C1=O to have a lower LogP value.,CC[C@]1(c2ccccc2)NC(=O)N(Cc2cc(=O)n(C)c(=O)n2C)C1=O,0.44130000000000025
+51627,Modify the molecule COc1cc(C)sc1C(=O)NNC(=O)Cc1cccc2ccccc12 to have a higher LogP value.,COc1cc(C)sc1C(=O)NNC(=O)Cc1cccc2ccccc12,3.2220200000000014
+77417,Please modify the molecule N#C[C@@H](C(=O)c1cscn1)c1nc(N)nc(Nc2ccccc2)n1 to decrease its LogP value.,N#C[C@@H](C(=O)c1cscn1)c1nc(N)nc(Nc2ccccc2)n1,2.14398
+18890,Optimize the molecule CC(C)([C@@H](N)c1ccc(Cl)s1)[NH+]1CCCCC1 to have a higher LogP value.,CC(C)([C@@H](N)c1ccc(Cl)s1)[NH+]1CCCCC1,2.2487000000000004
+42285,Please optimize the molecule Cc1nn(C)c(C)c1CC(=O)Nc1ccccc1N1CCc2sccc2C1 to have a higher LogP value.,Cc1nn(C)c(C)c1CC(=O)Nc1ccccc1N1CCc2sccc2C1,3.8423400000000028
+41022,Modify the molecule CCOC(=O)C1(C)CCN(C(=O)c2oc(C)nc2C)CC1 to have a higher LogP value.,CCOC(=O)C1(C)CCN(C(=O)c2oc(C)nc2C)CC1,2.0968400000000003
+102761,Optimize the molecule Cc1ccc(-c2nnc(C[NH2+]CCn3cc(C)cn3)o2)cc1 to have a higher LogP value.,Cc1ccc(-c2nnc(C[NH2+]CCn3cc(C)cn3)o2)cc1,1.3135399999999993
+51754,Please modify the molecule O=C(NCc1c(O)ccc2c1CCCC2)N[C@@H]1CCN(CC(F)(F)F)C1 to decrease its LogP value.,O=C(NCc1c(O)ccc2c1CCCC2)N[C@@H]1CCN(CC(F)(F)F)C1,2.706800000000001
+77364,Please modify the molecule Cc1noc(CCCNC(=O)N2C[C@@H](C)[C@H]2c2ccccc2)n1 to increase its LogP value.,Cc1noc(CCCNC(=O)N2C[C@@H](C)[C@H]2c2ccccc2)n1,2.7132200000000006
+230722,Please modify the molecule N#Cc1ccc(Cl)cc1NC(=O)C(=O)NCCC(c1ccccc1)c1ccccc1 to decrease its LogP value.,N#Cc1ccc(Cl)cc1NC(=O)C(=O)NCCC(c1ccccc1)c1ccccc1,4.4885800000000025
+149099,Optimize the molecule COC(=O)c1cc(S(=O)(=O)NCc2cc3ccccc3o2)cn1C to have a lower LogP value.,COC(=O)c1cc(S(=O)(=O)NCc2cc3ccccc3o2)cn1C,2.0364
+67521,Please optimize the molecule COc1ccc(CC(=O)Nc2ccn(Cc3cccc4ccccc34)n2)cc1 to have a lower LogP value.,COc1ccc(CC(=O)Nc2ccn(Cc3cccc4ccccc34)n2)cc1,4.274400000000003
+152409,Modify the molecule Cc1ccccc1[C@H]1CC(=O)c2c(C)nc(NCCCN3CCOCC3)nc2C1 to increase its LogP value.,Cc1ccccc1[C@H]1CC(=O)c2c(C)nc(NCCCN3CCOCC3)nc2C1,3.140340000000002
+6719,Please optimize the molecule COc1ncccc1Cn1cc(CCO)nn1 to have a lower LogP value.,COc1ncccc1Cn1cc(CCO)nn1,0.26479999999999976
+238828,Please modify the molecule C/C(=N\NC(=O)CNc1ccc(C)cc1)c1ccc(N)cc1 to decrease its LogP value.,C/C(=N\NC(=O)CNc1ccc(C)cc1)c1ccc(N)cc1,2.5295199999999998
+24122,Please modify the molecule CC[NH+](Cc1nc2cc(N)ccc2o1)C1CCCCC1 to increase its LogP value.,CC[NH+](Cc1nc2cc(N)ccc2o1)C1CCCCC1,2.1475
+47427,Please optimize the molecule CCOc1cc(SC(=S)N2CCCC2)ccc1[N+](=O)[O-] to have a higher LogP value.,CCOc1cc(SC(=S)N2CCCC2)ccc1[N+](=O)[O-],3.466300000000002
+249108,Please optimize the molecule NC(=O)N1CCC[C@@H](C(=O)Oc2ccc(Br)cc2)C1 to have a lower LogP value.,NC(=O)N1CCC[C@@H](C(=O)Oc2ccc(Br)cc2)C1,2.1452
+177687,Please optimize the molecule CS(=O)(=O)NC[C@H]1CCCN(C(=O)Cn2nnc3ccccc32)C1 to have a higher LogP value.,CS(=O)(=O)NC[C@H]1CCCN(C(=O)Cn2nnc3ccccc32)C1,0.21910000000000074
+221043,Please optimize the molecule CC[C@@H](Nc1ccn(C)n1)C(=O)[O-] to have a lower LogP value.,CC[C@@H](Nc1ccn(C)n1)C(=O)[O-],-0.6395000000000004
+69977,Modify the molecule CCS[C@H]1CCCC[C@H]1NC(=O)NCc1[nH+]ccn1CC(C)C to increase its LogP value.,CCS[C@H]1CCCC[C@H]1NC(=O)NCc1[nH+]ccn1CC(C)C,2.8217000000000008
+144097,Modify the molecule C=CCN1C(=O)C(C#N)=C(C)/C(=C\c2cn(-c3ccccc3)nc2-c2ccc(SCC)cc2)C1=O to have a lower LogP value.,C=CCN1C(=O)C(C#N)=C(C)/C(=C\c2cn(-c3ccccc3)nc2-c2ccc(SCC)cc2)C1=O,5.429580000000004
+158111,Modify the molecule COc1ccccc1NC(=O)N1CCC(CNC(=O)Cc2ccc([N+](=O)[O-])cc2)CC1 to decrease its LogP value.,COc1ccccc1NC(=O)N1CCC(CNC(=O)Cc2ccc([N+](=O)[O-])cc2)CC1,3.2062000000000017
+99132,Please modify the molecule Cc1ccc(N2CCCN(Cc3cnc(-c4cccnc4)s3)CC2)nn1 to decrease its LogP value.,Cc1ccc(N2CCCN(Cc3cnc(-c4cccnc4)s3)CC2)nn1,3.0158200000000015
+127764,Please modify the molecule Fc1ccc(-c2noc(CC3C[NH2+]C3)n2)nc1 to increase its LogP value.,Fc1ccc(-c2noc(CC3C[NH2+]C3)n2)nc1,0.006399999999999351
+187259,Please modify the molecule COc1ccc(Cl)c(NNC(=O)NCC[NH+]2CCC[C@@H](C)C2)c1 to decrease its LogP value.,COc1ccc(Cl)c(NNC(=O)NCC[NH+]2CCC[C@@H](C)C2)c1,1.2895000000000003
+83707,Modify the molecule CCN(CC)c1ccc(C(=O)N/N=C(/C)c2cccnc2)cc1 to increase its LogP value.,CCN(CC)c1ccc(C(=O)N/N=C(/C)c2cccnc2)cc1,3.081800000000001
+77596,Optimize the molecule O=C(NC[C@@H](O)c1ccc(C(F)(F)F)cc1)c1cnccn1 to have a higher LogP value.,O=C(NC[C@@H](O)c1ccc(C(F)(F)F)cc1)c1cnccn1,1.9588
+34200,Please optimize the molecule C[C@H]1C(=O)N(CC(=O)NC(=O)NC(C)(C)C)C(=O)N1c1ccc(F)cc1 to have a lower LogP value.,C[C@H]1C(=O)N(CC(=O)NC(=O)NC(C)(C)C)C(=O)N1c1ccc(F)cc1,1.6070999999999995
+203043,Optimize the molecule O=[N+]([O-])c1ccc(C[NH+]2CCC[C@@H]2C[C@H](O)c2ccco2)o1 to have a lower LogP value.,O=[N+]([O-])c1ccc(C[NH+]2CCC[C@@H]2C[C@H](O)c2ccco2)o1,1.4517999999999998
+45803,Modify the molecule COc1ccc2nc(-c3cccc(NC(=O)C(c4ccccc4)c4ccccc4)c3)cn2n1 to have a lower LogP value.,COc1ccc2nc(-c3cccc(NC(=O)C(c4ccccc4)c4ccccc4)c3)cn2n1,5.175500000000005
+15751,Modify the molecule Cc1ccc(S(=O)(=O)NCc2cnn(C)c2N)c(Br)c1 to decrease its LogP value.,Cc1ccc(S(=O)(=O)NCc2cnn(C)c2N)c(Br)c1,1.5517199999999998
+171058,Please optimize the molecule Cc1ccc(/C=N/N2C(=S)[NH+]=N[C@H]2c2ccc(C(C)(C)C)cc2)o1 to have a lower LogP value.,Cc1ccc(/C=N/N2C(=S)[NH+]=N[C@H]2c2ccc(C(C)(C)C)cc2)o1,3.051520000000002
+85827,Please modify the molecule CCc1nn(C)cc1C(=O)Oc1cccc(I)c1 to decrease its LogP value.,CCc1nn(C)cc1C(=O)Oc1cccc(I)c1,2.806300000000001
+1012,Please modify the molecule COc1ccc(S(=O)(=O)N(CC(=O)N2CC[NH2+]CC2)C(C)C)cc1 to increase its LogP value.,COc1ccc(S(=O)(=O)N(CC(=O)N2CC[NH2+]CC2)C(C)C)cc1,-0.5000999999999973
+215303,Modify the molecule O=C(NC[C@H]1CCCO1)[C@H](Cc1ccccc1)NC(=O)N1CCn2c1nc1ccccc12 to increase its LogP value.,O=C(NC[C@H]1CCCO1)[C@H](Cc1ccccc1)NC(=O)N1CCn2c1nc1ccccc12,2.4723999999999995
+105991,Please optimize the molecule Nc1cc(C[NH+]2CCC[C@H]2CO)ccc1[N+](=O)[O-] to have a higher LogP value.,Nc1cc(C[NH+]2CCC[C@H]2CO)ccc1[N+](=O)[O-],-0.28339999999999943
+204757,Optimize the molecule CC(=O)c1ccccc1NC(=O)CSc1nncs1 to have a higher LogP value.,CC(=O)c1ccccc1NC(=O)CSc1nncs1,2.4715000000000007
+81820,Modify the molecule O=C(COC(=O)c1ccccc1I)Nc1cccc(Cl)c1 to decrease its LogP value.,O=C(COC(=O)c1ccccc1I)Nc1cccc(Cl)c1,3.7401000000000026
+15080,Modify the molecule CCOC(=O)c1[nH]c(C)c(CCC(=O)Nc2cccc(C)c2C)c1C to have a higher LogP value.,CCOC(=O)c1[nH]c(C)c(CCC(=O)Nc2cccc(C)c2C)c1C,3.996380000000003
+4106,Modify the molecule O=C(N[C@H](c1ccccc1)C1CC1)N1CCC(OCc2ccc(F)cc2)CC1 to decrease its LogP value.,O=C(N[C@H](c1ccccc1)C1CC1)N1CCC(OCc2ccc(F)cc2)CC1,4.667600000000005
+205897,Please modify the molecule O=C(Nc1cccnc1)c1ccc(-c2cscn2)cc1 to increase its LogP value.,O=C(Nc1cccnc1)c1ccc(-c2cscn2)cc1,3.4574000000000016
+148380,Optimize the molecule COCCN1C(=O)C[C@](CC(=O)NC23C[C@@H]4C[C@@H](CC(O)(C4)C2)C3)(c2ccccc2C)C1=O to have a lower LogP value.,COCCN1C(=O)C[C@](CC(=O)NC23C[C@@H]4C[C@@H](CC(O)(C4)C2)C3)(c2ccccc2C)C1=O,2.2281199999999988
+213216,Modify the molecule CC(C)Oc1ncc(C(=O)N2C[C@H](C(N)=O)CC[C@@H]2C)cc1Cl to increase its LogP value.,CC(C)Oc1ncc(C(=O)N2C[C@H](C(N)=O)CC[C@@H]2C)cc1Cl,2.2481999999999998
+181540,Modify the molecule O=C(C[C@@H]1CCCC[C@H]1O)c1ccccc1 to decrease its LogP value.,O=C(C[C@@H]1CCCC[C@H]1O)c1ccccc1,2.810500000000001
+79705,Modify the molecule CC[C@H]1CN(C(=O)CCCN2C(=O)CNC2=O)CC[C@@H]1c1ccccc1 to have a higher LogP value.,CC[C@H]1CN(C(=O)CCCN2C(=O)CNC2=O)CC[C@@H]1c1ccccc1,2.3606999999999996
+94481,Modify the molecule COCCn1cc(NC(=O)N2CCC(Nc3cccc(OC)c3)CC2)cn1 to have a higher LogP value.,COCCn1cc(NC(=O)N2CCC(Nc3cccc(OC)c3)CC2)cn1,2.6465000000000005
+183039,Please optimize the molecule CC[C@H](C)CS(=O)(=O)NCCc1nc2ccccc2s1 to have a lower LogP value.,CC[C@H](C)CS(=O)(=O)NCCc1nc2ccccc2s1,2.8043000000000013
+84173,Modify the molecule C/C=C(\C)C[NH+]1C[C@@H]2C(C(=O)NCc3cn4cc(C)sc4n3)[C@@H]2C1 to increase its LogP value.,C/C=C(\C)C[NH+]1C[C@@H]2C(C(=O)NCc3cn4cc(C)sc4n3)[C@@H]2C1,1.0473199999999996
+25568,Optimize the molecule C[NH+]1CCN([C@@H]2CCCCN(C(=O)NCc3ccccn3)C2)CC1 to have a lower LogP value.,C[NH+]1CCN([C@@H]2CCCCN(C(=O)NCc3ccccn3)C2)CC1,-0.023999999999997135
+147384,Please modify the molecule Cc1cc(C(=O)N2CCC3=NN=C(c4ccc(F)c(F)c4)[C@@H]3C2)n(C)n1 to decrease its LogP value.,Cc1cc(C(=O)N2CCC3=NN=C(c4ccc(F)c(F)c4)[C@@H]3C2)n(C)n1,2.3277200000000002
+46548,Modify the molecule O=C(CCN1C(=O)NC2(CCCC2)C1=O)NC[C@H]1COc2ccccc2O1 to have a lower LogP value.,O=C(CCN1C(=O)NC2(CCCC2)C1=O)NC[C@H]1COc2ccccc2O1,1.1973000000000003
+95908,Modify the molecule NC(=O)c1cccnc1N1CCN(CN2CCCCC2=O)CC1 to have a lower LogP value.,NC(=O)c1cccnc1N1CCN(CN2CCCCC2=O)CC1,0.2724999999999993
+244293,Please optimize the molecule COC(=O)CN1C(=O)/C(=N\NC(=O)COc2cc(C)c(Cl)c(C)c2)c2ccccc21 to have a higher LogP value.,COC(=O)CN1C(=O)/C(=N\NC(=O)COc2cc(C)c(Cl)c(C)c2)c2ccccc21,2.3757400000000004
+157696,Modify the molecule COc1ccc(/C=C2/SC(=S)N(c3cccc(C(F)(F)F)c3)C2=O)cc1 to increase its LogP value.,COc1ccc(/C=C2/SC(=S)N(c3cccc(C(F)(F)F)c3)C2=O)cc1,5.119800000000002
+46228,Please optimize the molecule Cc1cc(N(C)Cc2nccn2Cc2ccccc2)n2ncnc2n1 to have a higher LogP value.,Cc1cc(N(C)Cc2nccn2Cc2ccccc2)n2ncnc2n1,2.3139200000000004
+13038,Please optimize the molecule CCc1ccc(CC)c(NC(=O)[C@H](C)OCC2CC2)c1 to have a higher LogP value.,CCc1ccc(CC)c(NC(=O)[C@H](C)OCC2CC2)c1,3.565000000000002
+117223,Optimize the molecule CCc1nc(N(C)C)c2c3c(sc2n1)CCC3 to have a higher LogP value.,CCc1nc(N(C)C)c2c3c(sc2n1)CCC3,2.8084000000000007
+244570,Modify the molecule COc1ccc(-c2c3sc(=O)[nH]c3nc3c2c(=O)[nH]n3C(C)C)c(OC)c1OC to have a lower LogP value.,COc1ccc(-c2c3sc(=O)[nH]c3nc3c2c(=O)[nH]n3C(C)C)c(OC)c1OC,2.9013000000000018
+178035,Please modify the molecule CC[NH2+][C@@H](C=C(C)C)[C@@H]1CCOc2ccccc21 to decrease its LogP value.,CC[NH2+][C@@H](C=C(C)C)[C@@H]1CCOc2ccccc21,2.4708000000000006
+57532,Modify the molecule CCCc1c(N)nnn1Cc1nc(C)c(C)s1 to decrease its LogP value.,CCCc1c(N)nnn1Cc1nc(C)c(C)s1,1.93444
+125057,Please modify the molecule C[C@H]1C[C@H](NC(=O)Cc2csc(NC(=O)c3cccs3)n2)CC(C)(C)C1 to decrease its LogP value.,C[C@H]1C[C@H](NC(=O)Cc2csc(NC(=O)c3cccs3)n2)CC(C)(C)C1,4.330400000000004
+171884,Optimize the molecule Cc1ccc(-c2nn3c(=O)cc(CNC(=O)Nc4cc(C)ccc4C)nc3s2)cc1 to have a lower LogP value.,Cc1ccc(-c2nn3c(=O)cc(CNC(=O)Nc4cc(C)ccc4C)nc3s2)cc1,4.064960000000002
+146537,Modify the molecule O=C1N[C@]2(CCCc3ccccc32)C(=O)N1Cc1nnc(-c2ccc(Cl)cc2)o1 to have a higher LogP value.,O=C1N[C@]2(CCCc3ccccc32)C(=O)N1Cc1nnc(-c2ccc(Cl)cc2)o1,3.673600000000002
+59196,Modify the molecule CC[C@H](C)[C@@](C)(O)C[NH2+][C@@H](C)c1cnc2cc(C)nn2c1C to decrease its LogP value.,CC[C@H](C)[C@@](C)(O)C[NH2+][C@@H](C)c1cnc2cc(C)nn2c1C,1.7676399999999994
+139131,Optimize the molecule C#CCN1CCN(CC(=O)Nc2cc(OC)ccc2OC)CC1 to have a lower LogP value.,C#CCN1CCN(CC(=O)Nc2cc(OC)ccc2OC)CC1,0.8930999999999996
+83736,Modify the molecule N/C(N[C@H]1CCOc2ccccc21)=[NH+]\Cc1ccc(Cn2cncn2)cc1 to decrease its LogP value.,N/C(N[C@H]1CCOc2ccccc21)=[NH+]\Cc1ccc(Cn2cncn2)cc1,0.3351000000000002
+48363,Optimize the molecule COc1ccc([C@@](C)([NH3+])[C@H]2CCOC3(CCCC3)C2)cc1 to have a lower LogP value.,COc1ccc([C@@](C)([NH3+])[C@H]2CCOC3(CCCC3)C2)cc1,2.891700000000001
+246518,Optimize the molecule Cc1c(C(=O)NCCc2ccccc2)cnn1-c1ccncc1 to have a higher LogP value.,Cc1c(C(=O)NCCc2ccccc2)cnn1-c1ccncc1,2.5482200000000006
+186406,Optimize the molecule COc1ccccc1Oc1ncnc(NNC(=O)c2ccc(Br)cc2)c1N to have a higher LogP value.,COc1ccccc1Oc1ncnc(NNC(=O)c2ccc(Br)cc2)c1N,3.3791
+229481,Please optimize the molecule Cc1ccc(NC(=O)c2ccc[n+]([O-])c2)cc1S(C)(=O)=O to have a higher LogP value.,Cc1ccc(NC(=O)c2ccc[n+]([O-])c2)cc1S(C)(=O)=O,1.28422
+239123,Modify the molecule CCN(CC)C(=O)[C@H]1Sc2nnc(C)n2N[C@@H]1c1ccc(OC)c(Br)c1 to increase its LogP value.,CCN(CC)C(=O)[C@H]1Sc2nnc(C)n2N[C@@H]1c1ccc(OC)c(Br)c1,2.985120000000001
+112397,Modify the molecule CC(=O)Nc1cc(C)nn1-c1ncnc2c1cnn2-c1ccc(C)cc1C to decrease its LogP value.,CC(=O)Nc1cc(C)nn1-c1ncnc2c1cnn2-c1ccc(C)cc1C,2.8848600000000015
+233635,Please modify the molecule CCOC(=O)[C@@H]1CC(=O)N(c2ccc(Br)cc2C)C1 to increase its LogP value.,CCOC(=O)[C@@H]1CC(=O)N(c2ccc(Br)cc2C)C1,2.673520000000001
+95711,Please optimize the molecule Cc1ccc(N2C[C@H](C(=O)Nc3nnc(CC(C)(C)C)s3)CC2=O)cc1 to have a higher LogP value.,Cc1ccc(N2C[C@H](C(=O)Nc3nnc(CC(C)(C)C)s3)CC2=O)cc1,3.426720000000002
+164523,Please modify the molecule CCn1cc(C[NH+]2CCC[C@H]2C(=O)[O-])c(C)n1 to decrease its LogP value.,CCn1cc(C[NH+]2CCC[C@H]2C(=O)[O-])c(C)n1,-1.491379999999998
+112959,Optimize the molecule Cc1nc(CC[NH+]2CCC(Oc3ccc(Cl)cc3)CC2)cs1 to have a higher LogP value.,Cc1nc(CC[NH+]2CCC(Oc3ccc(Cl)cc3)CC2)cs1,2.773720000000001
+172778,Modify the molecule C[C@@H](C(=O)[O-])[C@H](C)[S@@](=O)c1ccc(F)c(F)c1 to have a lower LogP value.,C[C@@H](C(=O)[O-])[C@H](C)[S@@](=O)c1ccc(F)c(F)c1,0.8469
+34908,Optimize the molecule CCC[C@@H](C)NC(=O)[C@@H]1CCCN(C(=O)C(C)(C)CC(C)C)C1 to have a higher LogP value.,CCC[C@@H](C)NC(=O)[C@@H]1CCCN(C(=O)C(C)(C)CC(C)C)C1,3.6021000000000027
+144914,Modify the molecule COc1ccccc1CNC(=O)CN1C[C@@H](C)C[C@H]([NH3+])C1 to have a lower LogP value.,COc1ccccc1CNC(=O)CN1C[C@@H](C)C[C@H]([NH3+])C1,0.26370000000000177
+195965,Modify the molecule Cc1ccc([C@](C)(O)CNC(=O)CN2CCCOC2=O)o1 to decrease its LogP value.,Cc1ccc([C@](C)(O)CNC(=O)CN2CCCOC2=O)o1,0.7540200000000001
+9579,Modify the molecule OCc1nn2c(c1Br)N[C@@H](c1ccc(Br)o1)C[C@@H]2C(F)(F)F to decrease its LogP value.,OCc1nn2c(c1Br)N[C@@H](c1ccc(Br)o1)C[C@@H]2C(F)(F)F,4.1537000000000015
+223988,Optimize the molecule Cc1ccc(CN(C)c2ccc([N+](=O)[O-])c3cnccc23)o1 to have a lower LogP value.,Cc1ccc(CN(C)c2ccc([N+](=O)[O-])c3cnccc23)o1,3.6808200000000024
+98054,Modify the molecule Clc1ccc2ncnc(O/N=C/c3ccc4c(c3)OCO4)c2c1 to have a lower LogP value.,Clc1ccc2ncnc(O/N=C/c3ccc4c(c3)OCO4)c2c1,3.424800000000001
+189624,Modify the molecule [S-]c1nnc(-c2cccnc2)n1/N=C/c1ccccc1Br to have a higher LogP value.,[S-]c1nnc(-c2cccnc2)n1/N=C/c1ccccc1Br,2.890600000000001
+40073,Please optimize the molecule O=C(Nc1ccc(F)c(Cl)c1)[C@H]1CCCN1S(=O)(=O)c1ccccc1 to have a lower LogP value.,O=C(Nc1ccc(F)c(Cl)c1)[C@H]1CCCN1S(=O)(=O)c1ccccc1,3.270900000000002
+189060,Please modify the molecule CN(C)S(=O)(=O)c1c[nH]c(C(=O)NCC(F)(F)F)c1 to decrease its LogP value.,CN(C)S(=O)(=O)c1c[nH]c(C(=O)NCC(F)(F)F)c1,0.5571
+210649,Please optimize the molecule CCOC(=O)C[C@@H](C)NC(=O)Cc1ccc(C)c(O)c1 to have a higher LogP value.,CCOC(=O)C[C@@H](C)NC(=O)Cc1ccc(C)c(O)c1,1.7010199999999995
+141028,Optimize the molecule COc1ccc(/C=N/NC(=O)c2cc(-c3ccc(Br)cc3)n[nH]2)cc1OC to have a lower LogP value.,COc1ccc(/C=N/NC(=O)c2cc(-c3ccc(Br)cc3)n[nH]2)cc1OC,3.620300000000001
+72379,Modify the molecule C=CCOc1ccccc1C(=O)Nc1ccc2ccccc2n1 to decrease its LogP value.,C=CCOc1ccccc1C(=O)Nc1ccc2ccccc2n1,4.0519000000000025
+8499,Please modify the molecule OCC#Cc1ccc(Br)cc1 to decrease its LogP value.,OCC#Cc1ccc(Br)cc1,1.7928999999999997
+28399,Please optimize the molecule COc1ccc(C(=O)Nc2nc(-c3ccc4c(c3)N(C)C(=O)[C@H](C)O4)cs2)cc1OC to have a higher LogP value.,COc1ccc(C(=O)Nc2nc(-c3ccc4c(c3)N(C)C(=O)[C@H](C)O4)cs2)cc1OC,3.8233000000000024
+249238,Modify the molecule CCc1ccccc1NC(=O)C(=O)NC[C@H](C)C[C@@H](C)O to increase its LogP value.,CCc1ccccc1NC(=O)C(=O)NC[C@H](C)C[C@@H](C)O,1.7106999999999999
+212519,Please modify the molecule Cc1ccc(NCC(=O)NNC(=O)c2ccc3c(c2)[nH]c(=O)n3C)cc1 to increase its LogP value.,Cc1ccc(NCC(=O)NNC(=O)c2ccc3c(c2)[nH]c(=O)n3C)cc1,1.0481199999999995
+174430,Please optimize the molecule Cc1ccccc1C(=O)NCCC(=O)OCc1scnc1C to have a lower LogP value.,Cc1ccccc1C(=O)NCCC(=O)OCc1scnc1C,2.623240000000001
+100541,Modify the molecule CN(CCc1ccccc1)S(=O)(=O)c1ccc2c(c1)OCCO2 to have a lower LogP value.,CN(CCc1ccccc1)S(=O)(=O)c1ccc2c(c1)OCCO2,2.3209999999999997
+59301,Modify the molecule CSc1ccccc1NC(=O)CN(C)C(=O)[C@@H]1CC(=O)N([C@H]2CCC[C@@H](C)[C@H]2C)C1 to have a lower LogP value.,CSc1ccccc1NC(=O)CN(C)C(=O)[C@@H]1CC(=O)N([C@H]2CCC[C@@H](C)[C@H]2C)C1,3.478600000000002
+103253,Optimize the molecule COc1cc(/C=C(\C#N)C(=O)Nc2cccc(C)c2C)cc2c1OCCO2 to have a lower LogP value.,COc1cc(/C=C(\C#N)C(=O)Nc2cccc(C)c2C)cc2c1OCCO2,3.6289200000000026
+158960,Please optimize the molecule C[C@@H]1C[C@H]1C(=O)N1CCN(Cc2ccc(F)c(F)c2)CC1 to have a lower LogP value.,C[C@@H]1C[C@H]1C(=O)N1CCN(Cc2ccc(F)c(F)c2)CC1,2.2650000000000006
+136931,Modify the molecule C[C@@H](C(=O)Nc1cccc(C2SCCS2)c1)n1cncn1 to increase its LogP value.,C[C@@H](C(=O)Nc1cccc(C2SCCS2)c1)n1cncn1,2.9564000000000012
+18470,Optimize the molecule C[C@@H](CNc1ncc(C(N)=O)cc1Cl)Nc1ccccc1 to have a higher LogP value.,C[C@@H](CNc1ncc(C(N)=O)cc1Cl)Nc1ccccc1,2.7464000000000004
+54669,Please modify the molecule C[NH+](C)[C@@H]1c2ccccc2C2(CCN(C(=O)CCc3cccnc3)CC2)[C@H]1O to increase its LogP value.,C[NH+](C)[C@@H]1c2ccccc2C2(CCN(C(=O)CCc3cccnc3)CC2)[C@H]1O,1.1346999999999996
+4173,Please modify the molecule CC(C)[NH+](C[C@@H](C)O)C1C[C@H](C)O[C@@H](C)C1 to increase its LogP value.,CC(C)[NH+](C[C@@H](C)O)C1C[C@H](C)O[C@@H](C)C1,0.6165000000000012
+222641,Please modify the molecule O=C(Cc1ccccc1)NCC(=O)N[C@@H]1CCN(c2cccc(Cl)c2)C1 to decrease its LogP value.,O=C(Cc1ccccc1)NCC(=O)N[C@@H]1CCN(c2cccc(Cl)c2)C1,2.3937999999999997
+228369,Modify the molecule CC(C)(C)[C@@H](Cn1cccn1)NC(=O)NC1CCCCC1 to decrease its LogP value.,CC(C)(C)[C@@H](Cn1cccn1)NC(=O)NC1CCCCC1,2.9297000000000013
+118576,Optimize the molecule CCOC(=O)C1=C(CN2CCc3c(F)ccc(F)c3C2)NC(=O)NC1 to have a higher LogP value.,CCOC(=O)C1=C(CN2CCc3c(F)ccc(F)c3C2)NC(=O)NC1,1.4528999999999999
+47957,Modify the molecule CCn1c(SCC(=O)NC2CCCC2)nnc1[C@H]1CCCN1C(=O)c1cccc(C)c1 to decrease its LogP value.,CCn1c(SCC(=O)NC2CCCC2)nnc1[C@H]1CCCN1C(=O)c1cccc(C)c1,3.7346200000000023
+230604,Optimize the molecule O=C(NOCC(=O)N1CCN(c2[nH+]cc(C(F)(F)F)cc2Cl)CC1)c1ccccc1 to have a lower LogP value.,O=C(NOCC(=O)N1CCN(c2[nH+]cc(C(F)(F)F)cc2Cl)CC1)c1ccccc1,2.1831000000000005
+11332,Modify the molecule Cc1cc(C)cc(NC(=O)[C@H](c2ccccc2)N2CC[NH+](CC(=O)N3CCOCC3)CC2)c1 to decrease its LogP value.,Cc1cc(C)cc(NC(=O)[C@H](c2ccccc2)N2CC[NH+](CC(=O)N3CCOCC3)CC2)c1,1.0425400000000018
+141697,Please optimize the molecule COc1cccc(C(=O)Nc2ccc(NC(=O)C3CC3)cc2)c1 to have a lower LogP value.,COc1cccc(C(=O)Nc2ccc(NC(=O)C3CC3)cc2)c1,3.296000000000001
+128676,Please optimize the molecule C=CCN(C(=O)CCCn1cnc2c1c(=O)n(C)c(=O)n2C)c1ccccc1 to have a lower LogP value.,C=CCN(C(=O)CCCn1cnc2c1c(=O)n(C)c(=O)n2C)c1ccccc1,1.4330999999999994
+59228,Please modify the molecule CC(C)(C)OC(=O)N1CCC[C@H](C[NH2+]C2CCC2)C1 to decrease its LogP value.,CC(C)(C)OC(=O)N1CCC[C@H](C[NH2+]C2CCC2)C1,1.7494
+98969,Optimize the molecule Fc1ccc(C[NH+]2CCC(NC3CCSCC3)CC2)cc1 to have a lower LogP value.,Fc1ccc(C[NH+]2CCC(NC3CCSCC3)CC2)cc1,1.8581999999999996
+2083,Please modify the molecule O=C(C[C@H](O)c1ccccc1)N1CCN(c2ccc(Cl)cc2)CC1 to decrease its LogP value.,O=C(C[C@H](O)c1ccccc1)N1CCN(c2ccc(Cl)cc2)CC1,3.112300000000001
+67655,Modify the molecule COC(=O)c1cccc(OC(=O)/C=C/c2ccccc2)c1 to increase its LogP value.,COC(=O)c1cccc(OC(=O)/C=C/c2ccccc2)c1,3.0920000000000014
+126012,Please optimize the molecule OC1(CNc2nc3ccc(F)cn3n2)CCCCCC1 to have a higher LogP value.,OC1(CNc2nc3ccc(F)cn3n2)CCCCCC1,2.3656000000000006
+73188,Modify the molecule C/C(=C/C[N+](C)(C)C)C[N+](C)(C)C to decrease its LogP value.,C/C(=C/C[N+](C)(C)C)C[N+](C)(C)C,1.3451
+223245,Modify the molecule Cc1cccc(C)c1NC(=O)CNC(=O)NCc1cc(C#N)ccc1F to have a higher LogP value.,Cc1cccc(C)c1NC(=O)CNC(=O)NCc1cc(C#N)ccc1F,2.7521200000000006
+115128,Modify the molecule CCc1cc(N(C)CC[C@H](C)O)nc(-c2ccccn2)n1 to have a higher LogP value.,CCc1cc(N(C)CC[C@H](C)O)nc(-c2ccccn2)n1,2.3081000000000005
+22505,Modify the molecule Cc1ccc(CCN(Cc2ccco2)C(=O)CC2(O)CCCC2)cc1 to have a lower LogP value.,Cc1ccc(CCN(Cc2ccco2)C(=O)CC2(O)CCCC2)cc1,3.8545200000000035
+16367,Modify the molecule CCc1nn(C)cc1NC(=O)N(CC)[C@@H](C)c1cc2ccccc2o1 to decrease its LogP value.,CCc1nn(C)cc1NC(=O)N(CC)[C@@H](C)c1cc2ccccc2o1,4.343700000000004
+194,Please optimize the molecule O=C(NCCS(=O)(=O)c1ccccc1)N1CCC[C@@H]2CCC[C@@H]21 to have a lower LogP value.,O=C(NCCS(=O)(=O)c1ccccc1)N1CCC[C@@H]2CCC[C@@H]21,2.434400000000001
+160720,Modify the molecule CC[C@@H](Oc1ccccc1F)C(=O)Nc1cc(OC)c(Cl)cc1OC to decrease its LogP value.,CC[C@@H](Oc1ccccc1F)C(=O)Nc1cc(OC)c(Cl)cc1OC,4.292400000000002
+54326,Please modify the molecule Cc1cc(C)n(C[C@@H](C)CNC(=O)NC23CC4CC(CC(C4)C2)C3)n1 to decrease its LogP value.,Cc1cc(C)n(C[C@@H](C)CNC(=O)NC23CC4CC(CC(C4)C2)C3)n1,3.404040000000002
+206696,Optimize the molecule C[C@H](NC(=O)c1ccc(Cl)cc1)C(=O)NNC(=O)c1cccs1 to have a higher LogP value.,C[C@H](NC(=O)c1ccc(Cl)cc1)C(=O)NNC(=O)c1cccs1,1.9809999999999999
+232878,Optimize the molecule CC1CCC(C(=O)c2ccccc2F)([NH+](C)C)CC1 to have a lower LogP value.,CC1CCC(C(=O)c2ccccc2F)([NH+](C)C)CC1,2.1018
+61419,Modify the molecule CCc1ccc(S(=O)(=O)N(CC)CC2CC[NH2+]CC2)s1 to decrease its LogP value.,CCc1ccc(S(=O)(=O)N(CC)CC2CC[NH2+]CC2)s1,1.2945
+112365,Please optimize the molecule CCCNC(=O)CNS(=O)(=O)c1ccc2c(c1)CCO2 to have a higher LogP value.,CCCNC(=O)CNS(=O)(=O)c1ccc2c(c1)CCO2,0.42599999999999977
+98035,Modify the molecule CCNC(=O)NC(C)(C)c1ncc(C)s1 to decrease its LogP value.,CCNC(=O)NC(C)(C)c1ncc(C)s1,2.00572
+15908,Please optimize the molecule CCc1nc(CN2CCC[C@H]([NH+](C)Cc3nc(C)c(C)o3)C2)no1 to have a lower LogP value.,CCc1nc(CN2CCC[C@H]([NH+](C)Cc3nc(C)c(C)o3)C2)no1,0.9161400000000008
+236079,Optimize the molecule C/C=C/C(=O)Nc1cccc(C)c1C to have a higher LogP value.,C/C=C/C(=O)Nc1cccc(C)c1C,2.8180400000000017
+170957,Please optimize the molecule CCOC(=O)c1c(NC(=O)C(C)C)sc2c1CC[C@@H](C)C2 to have a lower LogP value.,CCOC(=O)c1c(NC(=O)C(C)C)sc2c1CC[C@@H](C)C2,3.6441000000000026
+241546,Optimize the molecule Cc1ccc(O)c(CN(C)C[C@@H]2CC[NH+](Cc3ccccc3)C2)c1 to have a lower LogP value.,Cc1ccc(O)c(CN(C)C[C@@H]2CC[NH+](Cc3ccccc3)C2)c1,2.2374199999999993
+241063,Modify the molecule Cc1cccc(CN(C2CC2)S(=O)(=O)c2ccc3c(c2)C(=O)N(C)C3=O)c1 to have a higher LogP value.,Cc1cccc(CN(C2CC2)S(=O)(=O)c2ccc3c(c2)C(=O)N(C)C3=O)c1,2.5741200000000006
+106159,Modify the molecule CC[C@@H](C)[C@H](NC(=O)c1ccccc1)C(=O)N[C@@H](C)c1ccc(C)o1 to increase its LogP value.,CC[C@@H](C)[C@H](NC(=O)c1ccccc1)C(=O)N[C@@H](C)c1ccc(C)o1,3.6099200000000025
+200502,Modify the molecule O=C1C[C@H](Nc2cccc(F)c2)C(=O)N1c1cccc(Cl)c1 to increase its LogP value.,O=C1C[C@H](Nc2cccc(F)c2)C(=O)N1c1cccc(Cl)c1,3.2231000000000014
+56787,Optimize the molecule CCN(C(=O)[C@H](C)Sc1nc2sc(C)c(C)c2c(=O)n1CC)[C@H]1CCS(=O)(=O)C1 to have a higher LogP value.,CCN(C(=O)[C@H](C)Sc1nc2sc(C)c(C)c2c(=O)n1CC)[C@H]1CCS(=O)(=O)C1,2.610940000000001
+194692,Please optimize the molecule Cc1ccc(-n2ccnc2)c(C(=O)N2CCN(C(=O)[C@H]3C[C@H]3C)CC2)c1 to have a lower LogP value.,Cc1ccc(-n2ccnc2)c(C(=O)N2CCN(C(=O)[C@H]3C[C@H]3C)CC2)c1,2.1211199999999995
+197741,Modify the molecule COc1ccccc1OCc1ccc(C(=O)N2CCC[C@H](C(N)=O)C2)o1 to increase its LogP value.,COc1ccccc1OCc1ccc(C(=O)N2CCC[C@H](C(N)=O)C2)o1,2.2047
+145807,Modify the molecule O=C(Nc1cccc(NC(=O)c2cccnc2)c1)c1ccccc1 to increase its LogP value.,O=C(Nc1cccc(NC(=O)c2cccnc2)c1)c1ccccc1,3.5862000000000016
+109290,Optimize the molecule O=C([O-])c1cn2ccccc2n1 to have a lower LogP value.,O=C([O-])c1cn2ccccc2n1,-0.30220000000000047
+142399,Please optimize the molecule COc1ccc(F)cc1NC(=O)Cc1coc(-c2ccccc2)n1 to have a higher LogP value.,COc1ccc(F)cc1NC(=O)Cc1coc(-c2ccccc2)n1,3.6705000000000014
+149159,Please modify the molecule CC[C@@H]1Oc2ccc(S(=O)(=O)N3CCC(C(=O)N(C)C4CCCCC4)CC3)cc2NC1=O to decrease its LogP value.,CC[C@@H]1Oc2ccc(S(=O)(=O)N3CCC(C(=O)N(C)C4CCCCC4)CC3)cc2NC1=O,2.9879000000000007
+142849,Optimize the molecule COc1ccc(N2C(=O)CS[C@@]23C(=O)N(Cc2c(F)cccc2Cl)c2ccccc23)cc1 to have a lower LogP value.,COc1ccc(N2C(=O)CS[C@@]23C(=O)N(Cc2c(F)cccc2Cl)c2ccccc23)cc1,4.967300000000004
+169107,Modify the molecule CCC[C@@H](C)NC(=O)[C@@H]1CCCN(C(=O)Nc2cccc(-n3nnnc3C)c2)C1 to have a lower LogP value.,CCC[C@@H](C)NC(=O)[C@@H]1CCCN(C(=O)Nc2cccc(-n3nnnc3C)c2)C1,2.51942
+28236,Modify the molecule O=C(CNC(=O)c1ccc(Cl)cc1)N/N=C/c1ccc(F)cc1 to have a lower LogP value.,O=C(CNC(=O)c1ccc(Cl)cc1)N/N=C/c1ccc(F)cc1,2.3592000000000004
+39743,Optimize the molecule C[C@H]1C[C@@H](C)CN(C(=O)C(=O)Nc2ccc(Oc3cccnc3)nc2)C1 to have a higher LogP value.,C[C@H]1C[C@@H](C)CN(C(=O)C(=O)Nc2ccc(Oc3cccnc3)nc2)C1,2.711900000000001
+144959,Optimize the molecule O=[N+]([O-])c1cccc(OCc2nc(-c3ccncc3)no2)c1 to have a lower LogP value.,O=[N+]([O-])c1cccc(OCc2nc(-c3ccncc3)no2)c1,2.6188000000000002
+236919,Please optimize the molecule O=S(=O)(Nc1ccc2c(c1)CCCN2S(=O)(=O)c1cccs1)c1cccc(Cl)c1 to have a lower LogP value.,O=S(=O)(Nc1ccc2c(c1)CCCN2S(=O)(=O)c1cccs1)c1cccc(Cl)c1,4.343800000000003
+248624,Modify the molecule CCOC(=O)C[C@@H](C)CNC(=O)N[C@H]1c2ccccc2C[C@@H]1O to have a higher LogP value.,CCOC(=O)C[C@@H](C)CNC(=O)N[C@H]1c2ccccc2C[C@@H]1O,1.5331999999999997
+152073,Modify the molecule O=C1NC(=O)[C@](c2cccnc2)(C2CCN(C(=O)c3ccc[nH]3)CC2)N1 to have a higher LogP value.,O=C1NC(=O)[C@](c2cccnc2)(C2CCN(C(=O)c3ccc[nH]3)CC2)N1,0.9967999999999999
+184859,Modify the molecule COc1cc(OC)cc([C@H](N[C@@H](C)c2ccc(F)cn2)c2[nH+]ccn2C)c1 to have a higher LogP value.,COc1cc(OC)cc([C@H](N[C@@H](C)c2ccc(F)cn2)c2[nH+]ccn2C)c1,2.830700000000001
+123377,Please modify the molecule Cn1cc(C[NH+]2CCc3onc(-c4ccccc4F)c3C2)c(-c2ccccc2)n1 to decrease its LogP value.,Cn1cc(C[NH+]2CCc3onc(-c4ccccc4F)c3C2)c(-c2ccccc2)n1,3.022400000000001
+219949,Modify the molecule COc1ccc(F)cc1NC(=O)c1ccnc(C2CCCC2)n1 to have a lower LogP value.,COc1ccc(F)cc1NC(=O)c1ccnc(C2CCCC2)n1,3.534200000000002
+24351,Optimize the molecule CC(C)Cn1c(=O)c2ccc(C(=O)NC3CCCC3)cc2n2c(=O)n(Cc3ccc(Cl)cc3)nc12 to have a higher LogP value.,CC(C)Cn1c(=O)c2ccc(C(=O)NC3CCCC3)cc2n2c(=O)n(Cc3ccc(Cl)cc3)nc12,3.841000000000003
+101403,Modify the molecule CN1/C(=C(/C#N)C(=O)c2cc[n+](CC(=O)c3ccccc3)cc2)Nc2ccccc21 to increase its LogP value.,CN1/C(=C(/C#N)C(=O)c2cc[n+](CC(=O)c3ccccc3)cc2)Nc2ccccc21,3.336780000000002
+160524,Please modify the molecule Cc1ccccc1-c1noc(CCC(=O)NCc2ccc(F)cc2)n1 to increase its LogP value.,Cc1ccccc1-c1noc(CCC(=O)NCc2ccc(F)cc2)n1,3.4331200000000006
+233503,Optimize the molecule Cc1ccc2[nH]cc(CCC(=O)NC[C@H]3Cc4ccccc4O3)c2c1 to have a higher LogP value.,Cc1ccc2[nH]cc(CCC(=O)NC[C@H]3Cc4ccccc4O3)c2c1,3.5288200000000023
+88434,Please optimize the molecule O=C(NCC1(c2ccccc2)CCC1)c1ccc(Cn2cncn2)cc1 to have a lower LogP value.,O=C(NCC1(c2ccccc2)CCC1)c1ccc(Cn2cncn2)cc1,3.1781000000000015
+119190,Modify the molecule CC[C@H](CSC)[NH+](C)Cc1ccn(C(C)C)n1 to decrease its LogP value.,CC[C@H](CSC)[NH+](C)Cc1ccn(C(C)C)n1,1.6202999999999992
+171962,Modify the molecule CC[C@H](C)C(=O)N1Cc2ccccc2C[C@H]1C(=O)Nc1ccc(Cl)nc1 to have a lower LogP value.,CC[C@H](C)C(=O)N1Cc2ccccc2C[C@H]1C(=O)Nc1ccc(Cl)nc1,3.6731000000000025
+189977,Modify the molecule C[NH+](C)[C@H]1CCCN(Cn2nc(Br)nc2Br)C1 to increase its LogP value.,C[NH+](C)[C@H]1CCCN(Cn2nc(Br)nc2Br)C1,0.3694999999999997
+207145,Optimize the molecule C[C@H](Sc1nnc(-c2ccco2)n1C1CCCCC1)C(=O)N(C)Cc1ccccc1 to have a lower LogP value.,C[C@H](Sc1nnc(-c2ccco2)n1C1CCCCC1)C(=O)N(C)Cc1ccccc1,5.1825000000000045
+213309,Modify the molecule COc1ccccc1Nc1ncnc(N2CCc3ccccc3C2)c1N to increase its LogP value.,COc1ccccc1Nc1ncnc(N2CCc3ccccc3C2)c1N,3.3737000000000013
+221095,Please modify the molecule COc1ccc(CNC(=O)N[C@@H]2CCCC[C@@H]2C)cc1O to decrease its LogP value.,COc1ccc(CNC(=O)N[C@@H]2CCCC[C@@H]2C)cc1O,2.778700000000001
+212144,Please modify the molecule N#CCN(Cc1cnc(C2CCC2)s1)C1CCCC1 to increase its LogP value.,N#CCN(Cc1cnc(C2CCC2)s1)C1CCCC1,3.6787800000000033
+21436,Please modify the molecule C[NH+](C)[C@H](CNC(=O)N1CCC[C@H]1Cc1cccc(F)c1)c1ccco1 to decrease its LogP value.,C[NH+](C)[C@H](CNC(=O)N1CCC[C@H]1Cc1cccc(F)c1)c1ccco1,2.021
+79104,Please modify the molecule CN(C)c1ccc(CN(Cc2ccco2)C(=O)Nc2ccc(Cl)cc2)cc1 to increase its LogP value.,CN(C)c1ccc(CN(Cc2ccco2)C(=O)Nc2ccc(Cl)cc2)cc1,5.233300000000004
+165535,Please optimize the molecule C[C@H]1CCN(C(=O)Nc2cc(C(F)(F)F)c[nH]c2=O)[C@H](C)C1 to have a lower LogP value.,C[C@H]1CCN(C(=O)Nc2cc(C(F)(F)F)c[nH]c2=O)[C@H](C)C1,3.046000000000001
+194048,Modify the molecule CCCC(=O)N1CCC[C@@H](c2nc3c(c(=O)[nH]2)C[NH+](C)CC3)C1 to increase its LogP value.,CCCC(=O)N1CCC[C@@H](c2nc3c(c(=O)[nH]2)C[NH+](C)CC3)C1,-0.15319999999999734
+182116,Please optimize the molecule Cc1cc(C)c(N/C=C(\C#N)c2nc(-c3cccc([N+](=O)[O-])c3)cs2)c(C)c1 to have a higher LogP value.,Cc1cc(C)c(N/C=C(\C#N)c2nc(-c3cccc([N+](=O)[O-])c3)cs2)c(C)c1,5.620140000000004
+233874,Optimize the molecule CN(C)S(=O)(=O)n1cnc2ccccc21 to have a higher LogP value.,CN(C)S(=O)(=O)n1cnc2ccccc21,0.6907999999999996
+127049,Please modify the molecule Cc1cc(NC(=O)[C@H]2CCOc3ccccc32)n(-c2ccccc2F)n1 to increase its LogP value.,Cc1cc(NC(=O)[C@H]2CCOc3ccccc32)n(-c2ccccc2F)n1,3.824620000000002
+59785,Optimize the molecule CN(CCOCC1CC1)C(=O)c1ccc([S@](C)=O)cc1 to have a higher LogP value.,CN(CCOCC1CC1)C(=O)c1ccc([S@](C)=O)cc1,1.9226000000000003
+59662,Please optimize the molecule O=C(NCc1ccc2c(c1)OCO2)[C@@H]1COc2ccccc2C1 to have a higher LogP value.,O=C(NCc1ccc2c(c1)OCO2)[C@@H]1COc2ccccc2C1,2.2828
+56516,Modify the molecule CC[C@H](C)c1ccc(OCC(=O)Nc2ccc(NC(C)=O)cc2)cc1 to have a higher LogP value.,CC[C@H](C)c1ccc(OCC(=O)Nc2ccc(NC(C)=O)cc2)cc1,4.176000000000003
+144873,Please modify the molecule CCOC(=O)c1cnn2c(N)c(C(=O)Nc3ccccc3Cl)nnc12 to increase its LogP value.,CCOC(=O)c1cnn2c(N)c(C(=O)Nc3ccccc3Cl)nnc12,1.7888999999999995
+133726,Please optimize the molecule C[C@H]1Cc2ccccc2N1C(=O)Cn1c(=O)sc2cc(S(=O)(=O)N3CCCC3)ccc21 to have a higher LogP value.,C[C@H]1Cc2ccccc2N1C(=O)Cn1c(=O)sc2cc(S(=O)(=O)N3CCCC3)ccc21,2.8253000000000013
+154457,Modify the molecule Cn1nccc1CNC(=O)N1CCN(C(=O)c2cccs2)CC1 to increase its LogP value.,Cn1nccc1CNC(=O)N1CCN(C(=O)c2cccs2)CC1,1.1492
+204732,Modify the molecule Cn1cccc(NC(=O)NCC[C@@H](O)c2ccccc2)c1=O to have a lower LogP value.,Cn1cccc(NC(=O)NCC[C@@H](O)c2ccccc2)c1=O,1.6304999999999998
+13213,Optimize the molecule CC(C)(C)Cc1nnc(NC(=O)CS(=O)(=O)c2ccccc2)s1 to have a lower LogP value.,CC(C)(C)Cc1nnc(NC(=O)CS(=O)(=O)c2ccccc2)s1,2.5391000000000004
+239825,Please optimize the molecule O=S1(=O)CC[C@@H]([NH2+]Cc2ccc3c(c2)OCO3)C1 to have a lower LogP value.,O=S1(=O)CC[C@@H]([NH2+]Cc2ccc3c(c2)OCO3)C1,-0.33419999999999894
+208373,Please optimize the molecule CCN(CC(=O)N[C@@H]1CCS(=O)(=O)C1)S(=O)(=O)c1cc(Cl)ccc1Cl to have a higher LogP value.,CCN(CC(=O)N[C@@H]1CCS(=O)(=O)C1)S(=O)(=O)c1cc(Cl)ccc1Cl,1.3073000000000001
+176827,Modify the molecule CCCNC(=O)c1ccc(NC(=O)C2CCCC2)cc1 to have a higher LogP value.,CCCNC(=O)c1ccc(NC(=O)C2CCCC2)cc1,2.9551000000000016
+249377,Please modify the molecule CC(C)CO[C@@H]1CC[C@H](O)C1 to decrease its LogP value.,CC(C)CO[C@@H]1CC[C@H](O)C1,1.5724
+146378,Please optimize the molecule CN(C)C(=O)CCCC(=O)Nc1cccc(-c2nc(C3CC3)n[nH]2)c1 to have a lower LogP value.,CN(C)C(=O)CCCC(=O)Nc1cccc(-c2nc(C3CC3)n[nH]2)c1,2.5461
+123714,Modify the molecule COCCN(Cc1ccco1)C(=O)c1cc(C(C)C)n(C)n1 to have a lower LogP value.,COCCN(Cc1ccco1)C(=O)c1cc(C(C)C)n(C)n1,2.425300000000001
+138549,Please optimize the molecule C=CCCC(=O)Nc1ncc(C(F)(F)F)cc1Cl to have a lower LogP value.,C=CCCC(=O)Nc1ncc(C(F)(F)F)cc1Cl,3.658500000000002
+162908,Optimize the molecule O=C1N(CCc2ccccc2)C[C@H]2C[C@@H](c3cnc(-c4ccccc4)s3)[NH+]3CCC[C@]123 to have a higher LogP value.,O=C1N(CCc2ccccc2)C[C@H]2C[C@@H](c3cnc(-c4ccccc4)s3)[NH+]3CCC[C@]123,3.3735000000000017
+22769,Please modify the molecule O=S(=O)(c1ccc(Br)cc1Cl)N1CCN(Cc2cc(-c3ccccc3)no2)CC1 to increase its LogP value.,O=S(=O)(c1ccc(Br)cc1Cl)N1CCN(Cc2cc(-c3ccccc3)no2)CC1,4.264000000000005
+216501,Please optimize the molecule CS[C@H](C)C[NH2+][C@@H](C)c1nc2c(s1)CCCC2 to have a higher LogP value.,CS[C@H](C)C[NH2+][C@@H](C)c1nc2c(s1)CCCC2,2.397800000000001
+236434,Modify the molecule CCOC(=O)c1c(NC(=O)c2cc(=O)c3cc(C)cc(C)c3o2)sc(C)c1C to have a higher LogP value.,CCOC(=O)c1c(NC(=O)c2cc(=O)c3cc(C)cc(C)c3o2)sc(C)c1C,4.517180000000003
+229072,Please modify the molecule COC(=O)[C@H]1CN(c2cc3ccccc3c(=O)[nH]2)C[C@H]1C to decrease its LogP value.,COC(=O)[C@H]1CN(c2cc3ccccc3c(=O)[nH]2)C[C@H]1C,1.7733999999999999
+93356,Optimize the molecule COC(=O)[C@H](C)[C@H](C)[NH2+][C@H](C)c1ccccc1 to have a lower LogP value.,COC(=O)[C@H](C)[C@H](C)[NH2+][C@H](C)c1ccccc1,1.5085999999999995
+225299,Modify the molecule Cc1ccnn1CCC(=O)N1CCCC[C@@H]1c1ccnc2cc(C(C)(C)C)nn12 to decrease its LogP value.,Cc1ccnn1CCC(=O)N1CCCC[C@@H]1c1ccnc2cc(C(C)(C)C)nn12,3.675620000000002
+62382,Please modify the molecule O=C(Nc1cccc(-c2cn3ccsc3n2)c1)[C@H]1COc2ccccc2O1 to decrease its LogP value.,O=C(Nc1cccc(-c2cn3ccsc3n2)c1)[C@H]1COc2ccccc2O1,3.841300000000002
+51136,Please modify the molecule CC[C@H](C#N)OC(=O)c1cnn(Cc2ccccc2)c1 to decrease its LogP value.,CC[C@H](C#N)OC(=O)c1cnn(Cc2ccccc2)c1,2.3903800000000004
+87488,Modify the molecule CC(C)CNC(=O)Cc1ccc(NC(=O)c2cnc3c(c2)NC(=O)CO3)cc1 to have a lower LogP value.,CC(C)CNC(=O)Cc1ccc(NC(=O)c2cnc3c(c2)NC(=O)CO3)cc1,1.9794999999999994
+109860,Please modify the molecule O=C(C[NH+]1CCCCC1)N1CCC[C@@H]([NH+]2CCN(c3cccc(Cl)c3)CC2)C1 to increase its LogP value.,O=C(C[NH+]1CCCCC1)N1CCC[C@@H]([NH+]2CCN(c3cccc(Cl)c3)CC2)C1,0.1047000000000029
+187237,Please optimize the molecule COc1cccc(-n2cc(CN3C[C@@]4(CCOC4)CCC3=O)cn2)c1 to have a lower LogP value.,COc1cccc(-n2cc(CN3C[C@@]4(CCOC4)CCC3=O)cn2)c1,2.41
+151722,Please modify the molecule CCCN(Cc1csc(-c2ccc(C(F)(F)F)cc2)n1)[C@H]1CCS(=O)(=O)C1 to decrease its LogP value.,CCCN(Cc1csc(-c2ccc(C(F)(F)F)cc2)n1)[C@H]1CCS(=O)(=O)C1,4.228000000000004
+230567,Modify the molecule O=C(CNc1ccc(Cl)cc1NC(=O)c1ccco1)Nc1ccccc1 to have a higher LogP value.,O=C(CNc1ccc(Cl)cc1NC(=O)c1ccco1)Nc1ccccc1,4.235900000000002
+218138,Modify the molecule CCOc1ccc(-c2nc(NCc3cccc(OC)c3O)sc2C)cc1 to increase its LogP value.,CCOc1ccc(-c2nc(NCc3cccc(OC)c3O)sc2C)cc1,4.843520000000005
+141334,Please optimize the molecule CC(C)n1cc([C@@H](C)[NH2+]CCCC(=O)N2CCc3ccccc3C2)cn1 to have a higher LogP value.,CC(C)n1cc([C@@H](C)[NH2+]CCCC(=O)N2CCc3ccccc3C2)cn1,2.4535
+230546,Optimize the molecule O=C(OCc1cc(=O)oc2cc(O)c(O)cc12)c1nn(-c2ccccc2)c(=O)c2ccccc12 to have a lower LogP value.,O=C(OCc1cc(=O)oc2cc(O)c(O)cc12)c1nn(-c2ccccc2)c(=O)c2ccccc12,3.2603000000000018
+25722,Optimize the molecule O=C(c1ccco1)N1CCN(C(=O)[C@@H]2CCCN(c3nnc(-n4cccc4)s3)C2)CC1 to have a lower LogP value.,O=C(c1ccco1)N1CCN(C(=O)[C@@H]2CCCN(c3nnc(-n4cccc4)s3)C2)CC1,2.1228
+238875,Please modify the molecule CC[C@@H](C)C(=O)N1Cc2ccccc2C[C@H]1C(=O)Nc1cnn(C(C)C)c1 to decrease its LogP value.,CC[C@@H](C)C(=O)N1Cc2ccccc2C[C@H]1C(=O)Nc1cnn(C(C)C)c1,3.4021000000000017
+218841,Modify the molecule Cc1csc([C@@H](C)NCc2cccc(OC3CCCC3)c2)n1 to have a higher LogP value.,Cc1csc([C@@H](C)NCc2cccc(OC3CCCC3)c2)n1,4.623720000000003
+55216,Please optimize the molecule O=C1OCC(c2ccc(Br)s2)=C1c1ccc(F)cc1 to have a higher LogP value.,O=C1OCC(c2ccc(Br)s2)=C1c1ccc(F)cc1,4.117300000000002
+9807,Please optimize the molecule COc1ccccc1NC(=O)CNc1cccc(Cl)c1Cl to have a higher LogP value.,COc1ccccc1NC(=O)CNc1cccc(Cl)c1Cl,4.052600000000003
+38878,Modify the molecule Cc1ccc(C)c([C@H](C)NC(=O)c2ccc(CN3CCOCC3)cc2)c1 to have a higher LogP value.,Cc1ccc(C)c([C@H](C)NC(=O)c2ccc(CN3CCOCC3)cc2)c1,3.6266400000000028
+225327,Please optimize the molecule CN(C)C(=O)C1CC[NH+](Cc2cccc(C(=O)Nc3ccccc3)c2)CC1 to have a lower LogP value.,CN(C)C(=O)C1CC[NH+](Cc2cccc(C(=O)Nc3ccccc3)c2)CC1,1.8219999999999996
+163871,Please optimize the molecule O=C(Cc1cccs1)NCCCCN1C(=O)c2ccccc2C1=O to have a higher LogP value.,O=C(Cc1cccs1)NCCCCN1C(=O)c2ccccc2C1=O,2.483200000000001
+151299,Modify the molecule CCCCOCC(=O)N1CCc2c([nH]c3ccccc23)C1 to have a higher LogP value.,CCCCOCC(=O)N1CCc2c([nH]c3ccccc23)C1,2.869300000000001
+176804,Modify the molecule COc1cc(C[NH+]2C[C@H]3[C@@H](C2)OCCN3C)ccc1OCc1ccccc1 to have a higher LogP value.,COc1cc(C[NH+]2C[C@H]3[C@@H](C2)OCCN3C)ccc1OCc1ccccc1,1.3719000000000015
+29424,Optimize the molecule Cc1cc(C)n(-c2cncc(NCC(=O)N(C)CC(F)(F)F)n2)n1 to have a lower LogP value.,Cc1cc(C)n(-c2cncc(NCC(=O)N(C)CC(F)(F)F)n2)n1,1.7117399999999998
+218377,Modify the molecule CCN(Cc1cccc(F)c1)C(=O)/C=C/c1cc2c(cc1[N+](=O)[O-])OCO2 to have a higher LogP value.,CCN(Cc1cccc(F)c1)C(=O)/C=C/c1cc2c(cc1[N+](=O)[O-])OCO2,3.5245000000000024
+4111,Please modify the molecule O[C@@]12CCCC[C@@H]1[C@H](c1ccc(Cl)cc1Cl)[NH2+]CC2 to decrease its LogP value.,O[C@@]12CCCC[C@@H]1[C@H](c1ccc(Cl)cc1Cl)[NH2+]CC2,2.922900000000001
+73895,Optimize the molecule CCS(=O)(=O)CCC[C@@H](CBr)c1ccc(F)cc1 to have a higher LogP value.,CCS(=O)(=O)CCC[C@@H](CBr)c1ccc(F)cc1,3.5191000000000026
+54995,Please modify the molecule Cc1c(C)c(C)c([C@@H]([NH3+])CO)c(C)c1C to increase its LogP value.,Cc1c(C)c(C)c([C@@H]([NH3+])CO)c(C)c1C,1.5040000000000002
+16578,Modify the molecule N#Cc1nccnc1Sc1nnnn1C1CC1 to have a lower LogP value.,N#Cc1nccnc1Sc1nnnn1C1CC1,0.8208799999999998
+143251,Optimize the molecule CCOc1ccccc1OC/C([O-])=N/c1nc(-c2ccc(C)cc2)n[nH]1 to have a lower LogP value.,CCOc1ccccc1OC/C([O-])=N/c1nc(-c2ccc(C)cc2)n[nH]1,2.6481200000000005
+179448,Optimize the molecule CC(=O)Nc1cccc(NC(=O)COc2cccc3c2CCC[C@@H]3O)c1 to have a higher LogP value.,CC(=O)Nc1cccc(NC(=O)COc2cccc3c2CCC[C@@H]3O)c1,3.0322000000000013
+21051,Please optimize the molecule CC(C)Sc1ccc(C(=O)N2CCC(OCCN3C[C@@H](C)O[C@H](C)C3)CC2)cc1 to have a lower LogP value.,CC(C)Sc1ccc(C(=O)N2CCC(OCCN3C[C@@H](C)O[C@H](C)C3)CC2)cc1,3.917500000000003
+39093,Modify the molecule CC(C)c1nc(CC(=O)N(C2CCC(O)CC2)S(C)(=O)=O)cs1 to decrease its LogP value.,CC(C)c1nc(CC(=O)N(C2CCC(O)CC2)S(C)(=O)=O)cs1,1.9007000000000003
+171274,Please optimize the molecule O=C(Nc1nccs1)c1ccc(Cl)c(S(=O)(=O)N2CCCCCC2)c1 to have a lower LogP value.,O=C(Nc1nccs1)c1ccc(Cl)c(S(=O)(=O)N2CCCCCC2)c1,3.613500000000003
+147006,Please modify the molecule COc1ccccc1N(CCC[NH3+])C(=O)N1CCCCC1 to decrease its LogP value.,COc1ccccc1N(CCC[NH3+])C(=O)N1CCCCC1,1.7395
+139830,Modify the molecule CC[NH+](C)CC(=O)NCc1ccccc1Cn1cccn1 to have a higher LogP value.,CC[NH+](C)CC(=O)NCc1ccccc1Cn1cccn1,0.08220000000000116
+231701,Please modify the molecule Cc1ccc(C[C@@H](C)NC(=O)CSc2nc(C)n[nH]2)c(C)c1 to decrease its LogP value.,Cc1ccc(C[C@@H](C)NC(=O)CSc2nc(C)n[nH]2)c(C)c1,2.5694600000000003
+240402,Please optimize the molecule C[C@H]([NH3+])[C@H](Sc1ccncc1)c1ccccc1 to have a lower LogP value.,C[C@H]([NH3+])[C@H](Sc1ccncc1)c1ccccc1,2.5454000000000008
+213330,Please modify the molecule O=C(Nc1cc(Cl)ccc1-n1cncn1)c1ccc(OC(F)(F)F)cc1 to increase its LogP value.,O=C(Nc1cc(Cl)ccc1-n1cncn1)c1ccc(OC(F)(F)F)cc1,4.071600000000001
+146726,Optimize the molecule O=C(NC[C@H]1C[C@H](O)C[NH+]1Cc1ccccc1)c1cccs1 to have a higher LogP value.,O=C(NC[C@H]1C[C@H](O)C[NH+]1Cc1ccccc1)c1cccs1,0.696200000000001
+51270,Please optimize the molecule O=C(NC(c1cccs1)c1cccs1)c1cccc2cc[nH]c12 to have a lower LogP value.,O=C(NC(c1cccs1)c1cccs1)c1cccc2cc[nH]c12,4.810300000000003
+740,Please optimize the molecule CCc1ccc(/C=C(\C#N)C(N)=O)s1 to have a higher LogP value.,CCc1ccc(/C=C(\C#N)C(N)=O)s1,1.70278
+141518,Modify the molecule O=C(NC(=S)N1CCCC[C@H]1c1cccnc1)c1cccnc1 to have a higher LogP value.,O=C(NC(=S)N1CCCC[C@H]1c1cccnc1)c1cccnc1,2.7185000000000015
+115415,Please modify the molecule CC(=O)N[C@@H](CC(=O)NC1CCC(O)CC1)c1ccc(C)cc1 to decrease its LogP value.,CC(=O)N[C@@H](CC(=O)NC1CCC(O)CC1)c1ccc(C)cc1,1.9820199999999994
+185039,Optimize the molecule Cn1c(SCn2nnc3ccccc3c2=O)nnc1-c1ccncc1 to have a lower LogP value.,Cn1c(SCn2nnc3ccccc3c2=O)nnc1-c1ccncc1,1.7317999999999998
+120621,Please optimize the molecule COc1ccc(-c2nc3c(s2)CN(S(=O)(=O)c2ccc(Br)cc2)CC3)cc1 to have a higher LogP value.,COc1ccc(-c2nc3c(s2)CN(S(=O)(=O)c2ccc(Br)cc2)CC3)cc1,4.328200000000004
+25419,Optimize the molecule CCOc1ccccc1[C@@H](C)[NH2+]Cc1cc(F)cc(OC)c1 to have a lower LogP value.,CCOc1ccccc1[C@@H](C)[NH2+]Cc1cc(F)cc(OC)c1,3.0576000000000016
+237988,Please optimize the molecule O=C([O-])[C@H]1CC2=c3ccccc3=[NH+][C@H]2[C@@H](c2ccccc2)N1 to have a higher LogP value.,O=C([O-])[C@H]1CC2=c3ccccc3=[NH+][C@H]2[C@@H](c2ccccc2)N1,-2.2271999999999963
+173708,Please optimize the molecule COc1cc(C[NH2+]C2CC2)cc(Cl)c1OC[C@@H]1CCCO1 to have a lower LogP value.,COc1cc(C[NH2+]C2CC2)cc(Cl)c1OC[C@@H]1CCCO1,2.1322
+81109,Please optimize the molecule Cc1ccc(NC(=S)Nc2cc(C(F)(F)F)ccc2C)cc1 to have a lower LogP value.,Cc1ccc(NC(=S)Nc2cc(C(F)(F)F)ccc2C)cc1,5.131140000000003
+56929,Optimize the molecule N#CC1=C(N)Oc2cc(O)ccc2[C@H]1c1cc(C[NH+]2CCOCC2)cs1 to have a lower LogP value.,N#CC1=C(N)Oc2cc(O)ccc2[C@H]1c1cc(C[NH+]2CCOCC2)cs1,1.0869799999999996
+88041,Modify the molecule C[C@H](NC(=O)C(=O)Nc1ccc(Cl)c(Cl)c1)c1cccc(Cl)c1 to have a higher LogP value.,C[C@H](NC(=O)C(=O)Nc1ccc(Cl)c(Cl)c1)c1cccc(Cl)c1,4.462700000000002
+245417,Optimize the molecule Cc1ccc(C)n1CCN1CCN(S(=O)(=O)c2cnn(C)c2)CC1 to have a lower LogP value.,Cc1ccc(C)n1CCN1CCN(S(=O)(=O)c2cnn(C)c2)CC1,0.8449400000000002
+127626,Modify the molecule Cc1cc(C)c2c(C)c(C(=O)Nc3ccc4c(c3)NC(=O)[C@@H](C)O4)oc2c1 to decrease its LogP value.,Cc1cc(C)c2c(C)c(C(=O)Nc3ccc4c(c3)NC(=O)[C@@H](C)O4)oc2c1,4.329760000000002
+159341,Please modify the molecule C[C@H](Nc1ncnc2c1CCCCC2)c1ccccc1F to increase its LogP value.,C[C@H](Nc1ncnc2c1CCCCC2)c1ccccc1F,4.057700000000003
+226068,Please optimize the molecule Cc1noc(C2CCN(C(=O)N[C@@H](C)COc3ccc(F)cc3)CC2)n1 to have a higher LogP value.,Cc1noc(C2CCN(C(=O)N[C@@H](C)COc3ccc(F)cc3)CC2)n1,2.8736200000000016
+204191,Modify the molecule CCNC(=O)C[C@@H](C[NH3+])N1CCO[C@H]2CCCC[C@@H]21 to decrease its LogP value.,CCNC(=O)C[C@@H](C[NH3+])N1CCO[C@H]2CCCC[C@@H]21,-0.23349999999999804
+153957,Please optimize the molecule C[C@H]1CCC[C@@H]([NH+](C)C[C@H](O)COCc2ccc3c(c2)OCO3)C1 to have a higher LogP value.,C[C@H]1CCC[C@@H]([NH+](C)C[C@H](O)COCc2ccc3c(c2)OCO3)C1,1.3862000000000003
+246581,Modify the molecule Cc1cccc([N+](=O)[O-])c1NC(=O)COc1ccc(F)cc1Br to increase its LogP value.,Cc1cccc([N+](=O)[O-])c1NC(=O)COc1ccc(F)cc1Br,3.822320000000002
+239005,Modify the molecule C[C@H](NC(=O)c1ccc(CNC(=O)OC(C)(C)C)o1)c1cccc(C#N)c1 to have a higher LogP value.,C[C@H](NC(=O)c1ccc(CNC(=O)OC(C)(C)C)o1)c1cccc(C#N)c1,3.6669800000000023
+10002,Modify the molecule C[C@H]1CN(CCn2cc[nH+]c2)CC[C@@H]1[NH3+] to decrease its LogP value.,C[C@H]1CN(CCn2cc[nH+]c2)CC[C@@H]1[NH3+],-0.7454999999999974
+114307,Please optimize the molecule COCCn1c(C)cc(/C=C(/C#N)C(=O)N2CCCC[C@@H]2C)c1C to have a higher LogP value.,COCCn1c(C)cc(/C=C(/C#N)C(=O)N2CCCC[C@@H]2C)c1C,3.0593200000000014
+202409,Modify the molecule Cc1nn(C(C)C)c(C)c1NC(=O)[C@H]1CCCN(c2ncccn2)C1 to have a lower LogP value.,Cc1nn(C(C)C)c(C)c1NC(=O)[C@H]1CCCN(c2ncccn2)C1,2.7259400000000005
+187002,Please optimize the molecule CCN1/C(=N/C(=O)CCCC(=O)[O-])S[C@H]2CS(=O)(=O)C[C@@H]21 to have a higher LogP value.,CCN1/C(=N/C(=O)CCCC(=O)[O-])S[C@H]2CS(=O)(=O)C[C@@H]21,-0.9764999999999981
+246105,Optimize the molecule CC[C@H]1COCCN1Cc1cc(F)cc(Br)c1 to have a lower LogP value.,CC[C@H]1COCCN1Cc1cc(F)cc(Br)c1,3.1990000000000016
+30292,Optimize the molecule Cc1ccc(N2C(=O)C[C@H](Sc3ccccc3C(=O)[O-])C2=O)cc1 to have a lower LogP value.,Cc1ccc(N2C(=O)C[C@H](Sc3ccccc3C(=O)[O-])C2=O)cc1,1.7827199999999994
+168749,Modify the molecule CC[C@H](C)CS(=O)(=O)Cc1nc(-c2ccco2)no1 to increase its LogP value.,CC[C@H](C)CS(=O)(=O)Cc1nc(-c2ccco2)no1,2.2905000000000006
+18980,Optimize the molecule CC1(C)C[C@@H]2C[C@@](C)(CN2c2ncnc(NNC(=O)c3ccccc3F)c2N)C1 to have a higher LogP value.,CC1(C)C[C@@H]2C[C@@](C)(CN2c2ncnc(NNC(=O)c3ccccc3F)c2N)C1,3.359800000000001
+192095,Please optimize the molecule CCC[C@@H](C)N1C[C@@H](C(=O)NC2(C(N)=O)CCCC2)CC1=O to have a higher LogP value.,CCC[C@@H](C)N1C[C@@H](C(=O)NC2(C(N)=O)CCCC2)CC1=O,0.9377999999999995
+181946,Optimize the molecule COc1ccc(C(=O)Nc2c(O)cccc2F)cc1OC(F)F to have a lower LogP value.,COc1ccc(C(=O)Nc2c(O)cccc2F)cc1OC(F)F,3.393600000000001
+30452,Please modify the molecule Cc1cc(NC(=O)[C@H](C[NH3+])CC(C)C)ccc1Br to increase its LogP value.,Cc1cc(NC(=O)[C@H](C[NH3+])CC(C)C)ccc1Br,2.60022
+233685,Modify the molecule CN(C)c1ncccc1NC(=O)c1ccc(NC(=O)c2ccco2)s1 to have a higher LogP value.,CN(C)c1ncccc1NC(=O)c1ccc(NC(=O)c2ccco2)s1,3.306700000000001
+144382,Please optimize the molecule CC(C)[C@@H]1C[C@H](C(F)(F)F)n2nc([C@H]3CC[NH+](CC(N)=O)C3)cc2N1 to have a higher LogP value.,CC(C)[C@@H]1C[C@H](C(F)(F)F)n2nc([C@H]3CC[NH+](CC(N)=O)C3)cc2N1,0.684200000000001
+213849,Please modify the molecule C[C@@H]1OCC[C@@H]1C(=O)N1CC(C)(O)C1 to decrease its LogP value.,C[C@@H]1OCC[C@@H]1C(=O)N1CC(C)(O)C1,0.004599999999999993
+201424,Modify the molecule CCCS(=O)(=O)[N-]c1ccc(Nc2nccn(CC)c2=O)cc1 to have a higher LogP value.,CCCS(=O)(=O)[N-]c1ccc(Nc2nccn(CC)c2=O)cc1,2.751800000000001
+203647,Optimize the molecule C(=N/Nc1nc(Nc2ccccc2)nc(N2CCCC2)n1)\c1cccnc1 to have a lower LogP value.,C(=N/Nc1nc(Nc2ccccc2)nc(N2CCCC2)n1)\c1cccnc1,3.056400000000001
+194124,Modify the molecule CCc1ccccc1NC(=O)CNC(=O)N[C@H](c1ccc(Cl)cc1)C1CC1 to increase its LogP value.,CCc1ccccc1NC(=O)CNC(=O)N[C@H](c1ccc(Cl)cc1)C1CC1,4.291400000000003
+232513,Modify the molecule O=C(CCCC[C@H]1CCSS1)N[C@@H]1CCS(=O)(=O)C1 to have a lower LogP value.,O=C(CCCC[C@H]1CCSS1)N[C@@H]1CCS(=O)(=O)C1,2.0038
+7669,Modify the molecule CC[NH+](Cc1ccccc1NC(C)=O)[C@@H]1CCN(c2ccccc2)C1=O to have a lower LogP value.,CC[NH+](Cc1ccccc1NC(C)=O)[C@@H]1CCN(c2ccccc2)C1=O,1.8552999999999988
+61967,Optimize the molecule CCOc1ccc(N2C(=O)[C@@H]3CC4=c5ccccc5=[NH+][C@H]4[C@@H](c4ccccc4)N3C2=O)cc1 to have a lower LogP value.,CCOc1ccc(N2C(=O)[C@@H]3CC4=c5ccccc5=[NH+][C@H]4[C@@H](c4ccccc4)N3C2=O)cc1,1.3008000000000004
+185999,Optimize the molecule COc1cccc(C(=O)[C@@H]2CCC[NH+](Cc3nc(-c4cccs4)oc3C)C2)c1 to have a lower LogP value.,COc1cccc(C(=O)[C@@H]2CCC[NH+](Cc3nc(-c4cccs4)oc3C)C2)c1,3.397920000000002
+103901,Please optimize the molecule CCO[C@@H]1C[C@@H]1C(=O)NCc1ccc(OC)c(F)c1 to have a lower LogP value.,CCO[C@@H]1C[C@@H]1C(=O)NCc1ccc(OC)c(F)c1,1.8755
+82142,Modify the molecule Cc1ccc(C(C)C)c2c1[C@@H]([NH2+][C@@H]1CCCN(c3cccnn3)C1)CCO2 to have a higher LogP value.,Cc1ccc(C(C)C)c2c1[C@@H]([NH2+][C@@H]1CCCN(c3cccnn3)C1)CCO2,2.9644200000000014
+30377,Modify the molecule Clc1ccc2c(N3CC[NH+](Cc4csc5ccccc45)CC3)ncnc2c1 to increase its LogP value.,Clc1ccc2c(N3CC[NH+](Cc4csc5ccccc45)CC3)ncnc2c1,3.4030000000000022
+239811,Modify the molecule O=C(C[NH+]1CCCCC1)N[C@H]1CC(=O)N(Cc2cccc(F)c2)C1 to have a higher LogP value.,O=C(C[NH+]1CCCCC1)N[C@H]1CC(=O)N(Cc2cccc(F)c2)C1,0.11160000000000103
+75630,Please optimize the molecule CCC1(CC)CCN(C(=O)NC(=O)CCl)C1 to have a lower LogP value.,CCC1(CC)CCN(C(=O)NC(=O)CCl)C1,1.9734999999999998
+46431,Optimize the molecule Cc1cc(C)cc(NC(=O)CSc2nnc(NCc3ccccc3)s2)c1 to have a lower LogP value.,Cc1cc(C)cc(NC(=O)CSc2nnc(NCc3ccccc3)s2)c1,4.497840000000004
+237597,Modify the molecule C[C@H](C[NH2+]C1CCCC1)[NH+]1CCC(C)(C)C1 to have a higher LogP value.,C[C@H](C[NH2+]C1CCCC1)[NH+]1CCC(C)(C)C1,0.1957000000000011
+69198,Please optimize the molecule O=C(CSc1ncn[nH]1)N1CCc2ccccc2C1 to have a higher LogP value.,O=C(CSc1ncn[nH]1)N1CCc2ccccc2C1,1.4816999999999998
+98978,Modify the molecule O=C(NCc1ccncc1)Nc1ccc(Cl)c([N+](=O)[O-])c1 to have a higher LogP value.,O=C(NCc1ccncc1)Nc1ccc(Cl)c([N+](=O)[O-])c1,2.964900000000001
+214380,Please modify the molecule C/C=C/C[NH+](CCC)CC1CC[NH2+]CC1 to decrease its LogP value.,C/C=C/C[NH+](CCC)CC1CC[NH2+]CC1,-0.16919999999999735
+146748,Modify the molecule CSc1nccc(NC[C@@H]2CCCC[NH2+]2)n1 to have a higher LogP value.,CSc1nccc(NC[C@@H]2CCCC[NH2+]2)n1,0.7262999999999997
+129369,Modify the molecule C[C@H]1C[C@@H]1C(=O)NCCC1CCCCC1 to decrease its LogP value.,C[C@H]1C[C@@H]1C(=O)NCCC1CCCCC1,2.729000000000001
+82584,Optimize the molecule Cc1ccc(C(=O)N2CCCCC[C@H]2c2ccco2)c(C)n1 to have a higher LogP value.,Cc1ccc(C(=O)N2CCCCC[C@H]2c2ccco2)c(C)n1,4.048940000000003
+137306,Optimize the molecule COc1ccc(NC(=O)/C(C#N)=C/c2cccc(O)c2)cc1Cl to have a lower LogP value.,COc1ccc(NC(=O)/C(C#N)=C/c2cccc(O)c2)cc1Cl,3.5998800000000015
+248601,Please optimize the molecule O=C(NCc1ccc(Cl)nc1)c1c[nH]nc1-c1ccccc1 to have a higher LogP value.,O=C(NCc1ccc(Cl)nc1)c1c[nH]nc1-c1ccccc1,3.0551000000000013
+18165,Modify the molecule C[C@H]1C[C@H](NC(=O)Cn2ccnc2)CN1c1ccccc1 to decrease its LogP value.,C[C@H]1C[C@H](NC(=O)Cn2ccnc2)CN1c1ccccc1,1.666699999999999
+177121,Please modify the molecule C[C@H]1CCC[C@@]1(O)C1(C#N)CCCCC1 to decrease its LogP value.,C[C@H]1CCC[C@@]1(O)C1(C#N)CCCCC1,3.0115800000000013
+109817,Please optimize the molecule CCOC(=O)CS[C@H]1CC(=O)N(c2ccc(O)cc2C)C1=O to have a higher LogP value.,CCOC(=O)CS[C@H]1CC(=O)N(c2ccc(O)cc2C)C1=O,1.62882
+236141,Please optimize the molecule O=C(NC1CC[NH+](Cc2ccc(F)c(F)c2)CC1)[C@H]1CCCN1C(=O)C12CC3CC(CC(C3)C1)C2 to have a higher LogP value.,O=C(NC1CC[NH+](Cc2ccc(F)c(F)c2)CC1)[C@H]1CCCN1C(=O)C12CC3CC(CC(C3)C1)C2,2.8357
+241592,Optimize the molecule O=C(c1ccc(F)cc1Br)N1CCO[C@H](c2ccc(F)cc2)C1 to have a lower LogP value.,O=C(c1ccc(F)cc1Br)N1CCO[C@H](c2ccc(F)cc2)C1,3.9410000000000025
+198831,Modify the molecule C[C@@H]1c2cccn2CCN1S(=O)(=O)c1ccc2c(c1)oc(=O)n2C to decrease its LogP value.,C[C@@H]1c2cccn2CCN1S(=O)(=O)c1ccc2c(c1)oc(=O)n2C,1.6985000000000001
+187128,Please optimize the molecule Cc1cccc(C2=NC3(CCN(C(=O)OC(C)(C)C)CC3)NC2=S)c1 to have a higher LogP value.,Cc1cccc(C2=NC3(CCN(C(=O)OC(C)(C)C)CC3)NC2=S)c1,3.4419200000000023
+87536,Optimize the molecule Cc1c(Cl)ccc2sc(NC(=O)[C@@H]3CCCN(S(C)(=O)=O)C3)nc12 to have a higher LogP value.,Cc1c(Cl)ccc2sc(NC(=O)[C@@H]3CCCN(S(C)(=O)=O)C3)nc12,2.868220000000001
+26813,Please optimize the molecule C[C@H]1CCc2c(sc(NC(=O)Cc3cccc(C(F)(F)F)c3)c2C(N)=O)C1 to have a lower LogP value.,C[C@H]1CCc2c(sc(NC(=O)Cc3cccc(C(F)(F)F)c3)c2C(N)=O)C1,4.171800000000003
+61465,Modify the molecule CCOC(=O)c1c(NC(=O)c2ccc(C)c(S(=O)(=O)N3CCOCC3)c2)sc2c1CCC2 to have a lower LogP value.,CCOC(=O)c1c(NC(=O)c2ccc(C)c(S(=O)(=O)N3CCOCC3)c2)sc2c1CCC2,2.995120000000002
+75166,Please modify the molecule C/C=C(/C)C(=O)O[C@@H]1CCC[C@H]1n1cccn1 to decrease its LogP value.,C/C=C(/C)C(=O)O[C@@H]1CCC[C@H]1n1cccn1,2.4861000000000004
+98693,Please modify the molecule CCCOc1cccc(NC(=O)[C@H]2CC(=O)N(C)C2)c1 to decrease its LogP value.,CCCOc1cccc(NC(=O)[C@H]2CC(=O)N(C)C2)c1,1.8921999999999999
+233703,Modify the molecule C[C@H](CCc1ccccc1)CC(=O)N1C[C@@H](O)C[C@@H]1c1cc(F)ccc1F to decrease its LogP value.,C[C@H](CCc1ccccc1)CC(=O)N1C[C@@H](O)C[C@@H]1c1cc(F)ccc1F,4.258100000000003
+34999,Please optimize the molecule CC[C@@H](C)C(=O)N1CCC[C@H](C(=O)Nc2nc(-c3ccc(C)s3)c(C)s2)C1 to have a higher LogP value.,CC[C@@H](C)C(=O)N1CCC[C@H](C(=O)Nc2nc(-c3ccc(C)s3)c(C)s2)C1,4.711640000000004
+121670,Modify the molecule C[C@H]1CN(Cc2ccc(O)c(N)c2)C[C@H](C)O1 to have a lower LogP value.,C[C@H]1CN(Cc2ccc(O)c(N)c2)C[C@H](C)O1,1.5836000000000001
+112714,Modify the molecule Cc1ccccc1-c1cccc(C[NH+]2CCC[C@@H](c3ccn[nH]3)C2)c1 to decrease its LogP value.,Cc1ccccc1-c1cccc(C[NH+]2CCC[C@@H](c3ccn[nH]3)C2)c1,3.347620000000001
+208629,Please optimize the molecule O=C(N[C@@H]1CCCc2ccccc21)[C@@H]1CCCN(C2=NS(=O)(=O)c3ccccc32)C1 to have a lower LogP value.,O=C(N[C@@H]1CCCc2ccccc21)[C@@H]1CCCN(C2=NS(=O)(=O)c3ccccc32)C1,3.0413000000000014
+207209,Please optimize the molecule Cc1noc([C@H](C)OC(=O)[C@@H]2C[C@@H]2C)n1 to have a lower LogP value.,Cc1noc([C@H](C)OC(=O)[C@@H]2C[C@@H]2C)n1,1.63822
+177983,Modify the molecule CCOC(=O)c1cccc(OC(=O)C[C@@H]2C=CCC2)c1 to increase its LogP value.,CCOC(=O)c1cccc(OC(=O)C[C@@H]2C=CCC2)c1,3.1250000000000018
+195973,Optimize the molecule Cc1nc2n(n1)[C@H](c1ccc3c(c1)OCCCO3)C1=C(C[C@@H](c3ccco3)CC1=O)N2 to have a higher LogP value.,Cc1nc2n(n1)[C@H](c1ccc3c(c1)OCCCO3)C1=C(C[C@@H](c3ccco3)CC1=O)N2,3.756520000000002
+145700,Modify the molecule C[NH+]1CCCC[C@@H]1C(=O)N[C@H](CO)Cc1c[nH]c2ccccc12 to increase its LogP value.,C[NH+]1CCCC[C@@H]1C(=O)N[C@H](CO)Cc1c[nH]c2ccccc12,0.25470000000000154
+158228,Optimize the molecule COCCN(C(=O)[C@H]1CC[NH2+][C@@H]1C)[C@@H](C)C1CC1 to have a lower LogP value.,COCCN(C(=O)[C@H]1CC[NH2+][C@@H]1C)[C@@H](C)C1CC1,0.23170000000000202
+31210,Modify the molecule CS[C@H](CO)[C@H](C)NC(=O)N[C@@H](C)c1ccc(-c2cncnc2)cc1 to increase its LogP value.,CS[C@H](CO)[C@H](C)NC(=O)N[C@@H](C)c1ccc(-c2cncnc2)cc1,2.616200000000001
+26251,Optimize the molecule O=C(CCc1ccc(O)cc1)N/N=C\c1cc(Cl)cc(Cl)c1O to have a higher LogP value.,O=C(CCc1ccc(O)cc1)N/N=C\c1cc(Cl)cc(Cl)c1O,3.487500000000001
+1923,Modify the molecule COc1ccc2nc(-c3ccc(Cl)c(NC(=O)NCc4ccccc4)c3)cn2n1 to increase its LogP value.,COc1ccc2nc(-c3ccc(Cl)c(NC(=O)NCc4ccccc4)c3)cn2n1,4.3800000000000034
+205272,Please optimize the molecule Cn1ccnc1-c1nccn1C(c1ccccc1)c1ccccc1 to have a higher LogP value.,Cn1ccnc1-c1nccn1C(c1ccccc1)c1ccccc1,3.9213000000000022
+173964,Please modify the molecule Cc1ccc(CNC(=O)CSc2nnc3n(CC(C)C)c(=O)c4sccc4n23)cc1 to increase its LogP value.,Cc1ccc(CNC(=O)CSc2nnc3n(CC(C)C)c(=O)c4sccc4n23)cc1,3.478620000000002
+103611,Modify the molecule O=C1[C@H]2[C@@H]3C=C[C@@H](C3)[C@@H]2C(=O)N1CNc1ccccc1C(F)(F)F to increase its LogP value.,O=C1[C@H]2[C@@H]3C=C[C@@H](C3)[C@@H]2C(=O)N1CNc1ccccc1C(F)(F)F,2.881900000000001
+19314,Modify the molecule Cc1n[nH]c(C)c1NC(=O)NC1(c2ccc(F)cc2F)CCOCC1 to decrease its LogP value.,Cc1n[nH]c(C)c1NC(=O)NC1(c2ccc(F)cc2F)CCOCC1,3.1321400000000015
+144947,Optimize the molecule COCc1cc([N+](=O)[O-])ccc1NCc1ccc2c(c1)OCCCO2 to have a higher LogP value.,COCc1cc([N+](=O)[O-])ccc1NCc1ccc2c(c1)OCCCO2,3.5146000000000024
+103709,Modify the molecule COc1ccccc1NC(=O)COc1cccc(-c2noc(-c3ccc(F)cc3)n2)c1 to have a higher LogP value.,COc1ccccc1NC(=O)COc1cccc(-c2noc(-c3ccc(F)cc3)n2)c1,4.568800000000003
+209754,Please modify the molecule Cc1nonc1CN(C)C(=O)c1cc(-c2cccs2)nn1C to decrease its LogP value.,Cc1nonc1CN(C)C(=O)c1cc(-c2cccs2)nn1C,2.1122199999999998
+78979,Optimize the molecule CC/C(=N\NC(=O)[C@H]1C[C@@H]1c1ccccc1)c1ccc(C)cc1 to have a lower LogP value.,CC/C(=N\NC(=O)[C@H]1C[C@@H]1c1ccccc1)c1ccc(C)cc1,4.029020000000004
+162474,Optimize the molecule CC(C)c1cccc2c1OCC[C@@H]2[NH2+]C[C@]1(O)CCOC1 to have a higher LogP value.,CC(C)c1cccc2c1OCC[C@@H]2[NH2+]C[C@]1(O)CCOC1,1.3483999999999998
+2774,Modify the molecule CCOC(=O)C1=NN(c2ccccc2)[C@H](C(=O)NCC(F)(F)F)C1 to decrease its LogP value.,CCOC(=O)C1=NN(c2ccccc2)[C@H](C(=O)NCC(F)(F)F)C1,1.8629
+85643,Please optimize the molecule CC(=O)N/N=C(\C)CC(=O)Nc1ccc(Cl)cc1Cl to have a lower LogP value.,CC(=O)N/N=C(\C)CC(=O)Nc1ccc(Cl)cc1Cl,2.8340000000000005
+77755,Modify the molecule C[C@H](NC(=O)COc1cccc2c1OC(C)(C)C2)C1CC1 to have a lower LogP value.,C[C@H](NC(=O)COc1cccc2c1OC(C)(C)C2)C1CC1,2.693600000000001
+163221,Please optimize the molecule COCCOc1ncccc1C(=O)Nc1c(F)cc(F)cc1F to have a lower LogP value.,COCCOc1ncccc1C(=O)Nc1c(F)cc(F)cc1F,2.7764000000000006
+174250,Please optimize the molecule COc1cccc2cc(C(=O)C3=C([O-])C(=O)N(c4cc(C)on4)[C@H]3c3ccc(F)cc3)oc12 to have a higher LogP value.,COc1cccc2cc(C(=O)C3=C([O-])C(=O)N(c4cc(C)on4)[C@H]3c3ccc(F)cc3)oc12,3.4621200000000023
+62891,Modify the molecule C[C@H](O)[C@@H]1CCCC[NH+]1Cc1coc(-c2ccc(S(C)(=O)=O)cc2)n1 to have a lower LogP value.,C[C@H](O)[C@@H]1CCCC[NH+]1Cc1coc(-c2ccc(S(C)(=O)=O)cc2)n1,1.0632999999999997
+34265,Modify the molecule C=CCN(C(=O)[C@H](CC)c1ccccc1)c1nnc(-c2ccncc2)s1 to decrease its LogP value.,C=CCN(C(=O)[C@H](CC)c1ccccc1)c1nnc(-c2ccncc2)s1,4.3129000000000035
+235885,Modify the molecule Cc1cccc(-c2nnc(SCC(=O)Nc3cccc(C(F)(F)F)c3)n2N)c1 to decrease its LogP value.,Cc1cccc(-c2nnc(SCC(=O)Nc3cccc(C(F)(F)F)c3)n2N)c1,3.716920000000001
+30008,Please optimize the molecule O=C(C[C@@H]1CCCc2ccccc2[C@@H]1O)NCCO to have a higher LogP value.,O=C(C[C@@H]1CCCc2ccccc2[C@@H]1O)NCCO,1.1710999999999998
+69312,Optimize the molecule C[C@]1([C@@H](O)Cc2cccs2)CCCO1 to have a lower LogP value.,C[C@]1([C@@H](O)Cc2cccs2)CCCO1,2.2206
+194493,Modify the molecule Nc1c(S(=O)(=O)c2ccccc2)cnn1S(=O)(=O)c1ccc(Cl)cc1 to increase its LogP value.,Nc1c(S(=O)(=O)c2ccccc2)cnn1S(=O)(=O)c1ccc(Cl)cc1,2.1885000000000003
+187465,Optimize the molecule CC(=O)N[C@H](c1ccccn1)C1CC[NH+](Cc2cccc(OC(C)C)c2)CC1 to have a lower LogP value.,CC(=O)N[C@H](c1ccccn1)C1CC[NH+](Cc2cccc(OC(C)C)c2)CC1,2.5411
+215635,Modify the molecule O=C(CCN1CCCC1=O)NCC[C@@H](O)c1ccccc1 to decrease its LogP value.,O=C(CCN1CCCC1=O)NCC[C@@H](O)c1ccccc1,1.2387999999999997
+238819,Please modify the molecule Cc1cc(C)n(Cc2nnc(C)n2C2CC2)n1 to increase its LogP value.,Cc1cc(C)n(Cc2nnc(C)n2C2CC2)n1,1.7830599999999999
+179775,Modify the molecule CC(C)(C)n1nc2c(c1-n1cccc1)CN(C(=O)[C@@H]1COc3ccccc3O1)C2 to decrease its LogP value.,CC(C)(C)n1nc2c(c1-n1cccc1)CN(C(=O)[C@@H]1COc3ccccc3O1)C2,3.1110000000000015
+245768,Please optimize the molecule Cc1nc(C(C)(C)C)sc1[C@H](C)[NH2+][C@H](CO)C(C)C to have a higher LogP value.,Cc1nc(C(C)(C)C)sc1[C@H](C)[NH2+][C@H](CO)C(C)C,2.39032
+202507,Modify the molecule C[C@H](OC(=O)c1ccc2c(c1)C(=O)N(Cc1ccco1)C2=O)C(=O)NC1CCCCC1 to have a higher LogP value.,C[C@H](OC(=O)c1ccc2c(c1)C(=O)N(Cc1ccco1)C2=O)C(=O)NC1CCCCC1,3.070000000000002
+35975,Modify the molecule CS(=O)(=O)NC1CCC([NH2+][C@H]2CCCc3ccccc32)CC1 to have a higher LogP value.,CS(=O)(=O)NC1CCC([NH2+][C@H]2CCCc3ccccc32)CC1,1.4878
+95183,Optimize the molecule COc1cc(/C=C/C(=O)N(C)CCOc2ccc(Cl)cc2)cc2c1OCCO2 to have a higher LogP value.,COc1cc(/C=C/C(=O)N(C)CCOc2ccc(Cl)cc2)cc2c1OCCO2,3.6704000000000025
+49300,Please optimize the molecule CCS(=O)(=O)c1ccc(-c2cccc(NC(=O)c3cc(Cl)ccc3OC)c2)nn1 to have a lower LogP value.,CCS(=O)(=O)c1ccc(-c2cccc(NC(=O)c3cc(Cl)ccc3OC)c2)nn1,3.8515000000000024
+221589,Modify the molecule Cc1ccccc1-n1ccnc1SC[C@@H](O)CN1CCOCC1 to increase its LogP value.,Cc1ccccc1-n1ccnc1SC[C@@H](O)CN1CCOCC1,1.9659199999999997
+48337,Optimize the molecule O=C(NCCSc1ccccc1)NCCC(=O)N1CCCC1 to have a lower LogP value.,O=C(NCCSc1ccccc1)NCCC(=O)N1CCCC1,2.0904
+185482,Modify the molecule CCc1[nH+]c(C)cn1Cc1nc(-c2ccc3c(c2)OCO3)no1 to have a higher LogP value.,CCc1[nH+]c(C)cn1Cc1nc(-c2ccc3c(c2)OCO3)no1,2.0000199999999997
+210842,Modify the molecule CC(C)Cn1nccc1NC(=O)C[C@@H]1C=CCC1 to increase its LogP value.,CC(C)Cn1nccc1NC(=O)C[C@@H]1C=CCC1,2.8339000000000016
+48905,Optimize the molecule C[C@@H]1CCCN(C(=O)NCC(C)(C)c2ccncc2)CC1 to have a lower LogP value.,C[C@@H]1CCCN(C(=O)NCC(C)(C)c2ccncc2)CC1,3.190800000000002
+191345,Please optimize the molecule Cn1c(=O)n(Cc2ccc(Cl)cc2)c(=O)c2c1nc1n2CCN1c1ccccc1 to have a lower LogP value.,Cn1c(=O)n(Cc2ccc(Cl)cc2)c(=O)c2c1nc1n2CCN1c1ccccc1,2.7501000000000007
+172615,Modify the molecule CC(=O)c1ccc(-c2ccc(/C=N/[NH+]=C3/CCCCCN3)o2)cc1 to decrease its LogP value.,CC(=O)c1ccc(-c2ccc(/C=N/[NH+]=C3/CCCCCN3)o2)cc1,2.1258
+48762,Please optimize the molecule COc1cc(C(=O)N2Cc3cc4ccccc4nc3[C@@H]2C)cc(OC)c1OC to have a higher LogP value.,COc1cc(C(=O)N2Cc3cc4ccccc4nc3[C@@H]2C)cc(OC)c1OC,3.9776000000000034
+207118,Please modify the molecule Cc1cc(C)cc(NC(=O)CNc2cc3c(cc2Cl)NC(=O)CO3)c1 to decrease its LogP value.,Cc1cc(C)cc(NC(=O)CNc2cc3c(cc2Cl)NC(=O)CO3)c1,3.3383400000000005
+149222,Please modify the molecule Cc1cccc(N2CCN(c3ncnc(NCCCN4CCOCC4)c3N)CC2)c1C to decrease its LogP value.,Cc1cccc(N2CCN(c3ncnc(NCCCN4CCOCC4)c3N)CC2)c1C,2.1364400000000003
+183445,Modify the molecule Cn1ncc(N2CCO[C@@H](CCNc3nnc(C4CC4)o3)C2)cc1=O to increase its LogP value.,Cn1ncc(N2CCO[C@@H](CCNc3nnc(C4CC4)o3)C2)cc1=O,0.7480999999999993
+14777,Please modify the molecule COc1ccc(CCNC(=O)c2cc(-c3ccco3)on2)cc1OC to increase its LogP value.,COc1ccc(CCNC(=O)c2cc(-c3ccco3)on2)cc1OC,2.9243000000000015
+11861,Please modify the molecule O=C(C[NH+](Cc1ccco1)[C@H]1CCS(=O)(=O)C1)Nc1ccc(Br)cc1F to increase its LogP value.,O=C(C[NH+](Cc1ccco1)[C@H]1CCS(=O)(=O)C1)Nc1ccc(Br)cc1F,1.3919000000000004
+210791,Modify the molecule C[C@@H]1CN(C(=O)Nc2cccc(C(F)(F)F)c2)c2ccccc2S1 to have a lower LogP value.,C[C@@H]1CN(C(=O)Nc2cccc(C(F)(F)F)c2)c2ccccc2S1,5.238100000000003
+92698,Modify the molecule CCC[NH+]1CC[C@H](CNC(=O)Nc2cc(-c3ccccc3)nn2C(C)C)C1 to have a lower LogP value.,CCC[NH+]1CC[C@H](CNC(=O)Nc2cc(-c3ccccc3)nn2C(C)C)C1,2.5672999999999995
+98506,Modify the molecule NC(=O)c1ccc(Oc2cccc(C(=O)[O-])c2)nc1 to have a lower LogP value.,NC(=O)c1ccc(Oc2cccc(C(=O)[O-])c2)nc1,0.3362999999999998
+39159,Please modify the molecule COc1ccc(-c2cc3nc(C)c(C)c(NCCN4CCOCC4)n3n2)cc1 to decrease its LogP value.,COc1ccc(-c2cc3nc(C)c(C)c(NCCN4CCOCC4)n3n2)cc1,2.7658400000000007
+131283,Modify the molecule Cc1ccc(C[NH+]2CCC(CNC(=O)Nc3cccc(Br)c3)CC2)cc1 to decrease its LogP value.,Cc1ccc(C[NH+]2CCC(CNC(=O)Nc3cccc(Br)c3)CC2)cc1,3.3741200000000013
+106680,Please optimize the molecule CCc1ccc(NC(=O)[C@@H](NC(=O)N2C[C@@H]3C[C@H](C2)Cn2c3cccc2=O)C(C)C)cc1 to have a lower LogP value.,CCc1ccc(NC(=O)[C@@H](NC(=O)N2C[C@@H]3C[C@H](C2)Cn2c3cccc2=O)C(C)C)cc1,3.202700000000002
+150933,Modify the molecule CCc1cnc(C[NH+](C2CC2)[C@H](C)C2CC2)o1 to increase its LogP value.,CCc1cnc(C[NH+](C2CC2)[C@H](C)C2CC2)o1,1.5827999999999995
+222939,Modify the molecule COC(=O)[C@@H](NC(=O)Cc1ccc(C)o1)c1ccc(Cl)c(F)c1 to have a higher LogP value.,COC(=O)[C@@H](NC(=O)Cc1ccc(C)o1)c1ccc(Cl)c(F)c1,2.953520000000001
+218932,Please modify the molecule C[NH2+]Cc1cc(F)c(O[C@H]2CCCC[C@H]2O)c(F)c1 to increase its LogP value.,C[NH2+]Cc1cc(F)c(O[C@H]2CCCC[C@H]2O)c(F)c1,1.3403000000000003
+48061,Optimize the molecule Cc1ccc(NCc2ccccc2Br)c(C)n1 to have a higher LogP value.,Cc1ccc(NCc2ccccc2Br)c(C)n1,4.073040000000002
+79874,Optimize the molecule CCOc1ccc(NC(=O)CN2CCCCCCC2=O)c(C(F)(F)F)c1 to have a lower LogP value.,CCOc1ccc(NC(=O)CN2CCCCCCC2=O)c(C(F)(F)F)c1,3.835300000000003
+246144,Please optimize the molecule CC(C)[C@@H](NC(=O)c1ccccc1Cl)C(=O)OC[C@H]1CCCO1 to have a lower LogP value.,CC(C)[C@@H](NC(=O)c1ccccc1Cl)C(=O)OC[C@H]1CCCO1,2.816600000000001
+163381,Please optimize the molecule CCOc1ccc(NC(=O)[C@H]2C=C[C@@H]([NH3+])C2)cc1CO to have a higher LogP value.,CCOc1ccc(NC(=O)[C@H]2C=C[C@@H]([NH3+])C2)cc1CO,0.7026999999999999
+97745,Please optimize the molecule CCc1cc(=O)oc2cc(O[C@H](C)C(=O)N3CC[C@@]4(O)CCCC[C@@H]4C3)ccc12 to have a lower LogP value.,CCc1cc(=O)oc2cc(O[C@H](C)C(=O)N3CC[C@@]4(O)CCCC[C@@H]4C3)ccc12,3.2763000000000018
+164485,Modify the molecule CCOC(=O)C(=O)Nc1ccc(S(=O)(=O)NC(C)(C)C)cc1 to increase its LogP value.,CCOC(=O)C(=O)Nc1ccc(S(=O)(=O)NC(C)(C)C)cc1,1.2649999999999997
+202579,Modify the molecule CCn1cc[nH+]c1CN1CCN(Cc2ncc(C(C)(C)C)o2)C[C@@H]1C to decrease its LogP value.,CCn1cc[nH+]c1CN1CCN(Cc2ncc(C(C)(C)C)o2)C[C@@H]1C,2.3139000000000003
+166879,Modify the molecule Cc1ccn(-c2cnc(Br)cn2)n1 to have a lower LogP value.,Cc1ccn(-c2cnc(Br)cn2)n1,1.7332199999999998
+205751,Modify the molecule CCC[NH+]1CCC(N(C)[C@@H]2CCN(C(=O)OC(C)(C)C)C2)CC1 to have a higher LogP value.,CCC[NH+]1CCC(N(C)[C@@H]2CCN(C(=O)OC(C)(C)C)C2)CC1,1.384900000000001
+155628,Optimize the molecule COC(=O)[C@H](c1ccc(Cl)cc1)N1CCN(C(=O)Nc2ccccc2)CC1 to have a higher LogP value.,COC(=O)[C@H](c1ccc(Cl)cc1)N1CCN(C(=O)Nc2ccccc2)CC1,3.4038000000000013
+14603,Please modify the molecule CC[NH+](CC)CCn1/c(=N/C(=O)C2CCCC2)[nH]c2ccccc21 to decrease its LogP value.,CC[NH+](CC)CCn1/c(=N/C(=O)C2CCCC2)[nH]c2ccccc21,1.5116
+180248,Modify the molecule Cc1cccc(C[NH+](C)C[C@]2(C(=O)[O-])CCOC2)n1 to decrease its LogP value.,Cc1cccc(C[NH+](C)C[C@]2(C(=O)[O-])CCOC2)n1,-1.4386799999999973
+199120,Please optimize the molecule COCc1c(C(=O)NCc2ccccc2Cl)nnn1-c1cccc(C)c1 to have a lower LogP value.,COCc1c(C(=O)NCc2ccccc2Cl)nnn1-c1cccc(C)c1,3.3055200000000022
+135616,Please modify the molecule C/C(=C\c1ccccc1[N+](=O)[O-])C[NH2+]C(C)C to decrease its LogP value.,C/C(=C\c1ccccc1[N+](=O)[O-])C[NH2+]C(C)C,1.9699
+48451,Optimize the molecule CN(C)NC(=O)c1ccsc1NC(=O)Cc1ccccc1 to have a lower LogP value.,CN(C)NC(=O)c1ccsc1NC(=O)Cc1ccccc1,2.1357
+182051,Modify the molecule COc1cccc(OCc2ccc(C(N)=O)cc2N)c1 to have a lower LogP value.,COc1cccc(OCc2ccc(C(N)=O)cc2N)c1,1.9553
+161584,Modify the molecule Cc1ccccc1[C@H]1Nc2ccc(S(N)(=O)=O)cc2[C@@H]2C=CC[C@@H]12 to decrease its LogP value.,Cc1ccccc1[C@H]1Nc2ccc(S(N)(=O)=O)cc2[C@@H]2C=CC[C@@H]12,3.4689200000000016
+165341,Optimize the molecule CCc1cccc2c(CCNC(=O)Cc3ccc(C)c(O)c3)c[nH]c12 to have a higher LogP value.,CCc1cccc2c(CCNC(=O)Cc3ccc(C)c(O)c3)c[nH]c12,3.6457200000000016
+10337,Modify the molecule C[C@H]([NH2+]C1CCC(O)CC1)c1ccccc1O to decrease its LogP value.,C[C@H]([NH2+]C1CCC(O)CC1)c1ccccc1O,1.3200999999999994
+228233,Modify the molecule COCc1csc(NC(=O)NC[C@@](C)(O)c2ccc(F)cc2)n1 to have a lower LogP value.,COCc1csc(NC(=O)NC[C@@](C)(O)c2ccc(F)cc2)n1,2.4578000000000007
+57926,Modify the molecule Fc1cc(Oc2ncnc3c2CCCCC3)ccc1Br to increase its LogP value.,Fc1cc(Oc2ncnc3c2CCCCC3)ccc1Br,4.439400000000003
+142746,Optimize the molecule Cc1ccc(S(=O)(=O)N(C)C(C)C)cc1NCc1ccc(C#N)cc1 to have a higher LogP value.,Cc1ccc(S(=O)(=O)N(C)C(C)C)cc1NCc1ccc(C#N)cc1,3.5077000000000025
+162941,Optimize the molecule CC(C)(CNC(=O)NC[C@@H]1CC=CCC1)NC(=O)OC(C)(C)C to have a higher LogP value.,CC(C)(CNC(=O)NC[C@@H]1CC=CCC1)NC(=O)OC(C)(C)C,2.9452000000000016
+101087,Modify the molecule CCc1nn(C)c(OC)c1CN1CCC[NH+](CC2CCCCC2)CC1 to have a lower LogP value.,CCc1nn(C)c(OC)c1CN1CCC[NH+](CC2CCCCC2)CC1,1.6620000000000006
+65939,Modify the molecule O=C(NC[C@@H](c1ccccc1)[NH+]1CCCC1)c1ccc(C2SCCCS2)cc1 to decrease its LogP value.,O=C(NC[C@@H](c1ccccc1)[NH+]1CCCC1)c1ccc(C2SCCCS2)cc1,3.7051000000000025
+200835,Please modify the molecule CN(Cc1nnc(C2CC2)n1C)C(=O)N[C@H]1CC[C@H]([NH+](C)C)C1 to increase its LogP value.,CN(Cc1nnc(C2CC2)n1C)C(=O)N[C@H]1CC[C@H]([NH+](C)C)C1,-0.10049999999999804
+232069,Modify the molecule COc1ccc(CC(=O)NCC2CCN(C(=O)c3cc4ccccc4o3)CC2)cc1OC to increase its LogP value.,COc1ccc(CC(=O)NCC2CCN(C(=O)c3cc4ccccc4o3)CC2)cc1OC,3.661100000000003
+109649,Optimize the molecule CC[NH2+][C@@H](C(OC)OC)[C@H]1CCOC2(CCC2)C1 to have a lower LogP value.,CC[NH2+][C@@H](C(OC)OC)[C@H]1CCOC2(CCC2)C1,0.906500000000001
+219299,Please optimize the molecule C[NH2+][C@H](Cc1ccncc1)[C@@H]1CCOC2(CCSCC2)C1 to have a higher LogP value.,C[NH2+][C@H](Cc1ccncc1)[C@@H]1CCOC2(CCSCC2)C1,1.8783000000000005
+31882,Modify the molecule Cc1c(C(=O)NCC(F)(F)F)cccc1[N+](=O)[O-] to increase its LogP value.,Cc1c(C(=O)NCC(F)(F)F)cccc1[N+](=O)[O-],2.1953199999999997
+72663,Please optimize the molecule Cn1c(=O)oc2cc([C@H](Br)C3C(C)(C)C3(C)C)ccc21 to have a higher LogP value.,Cn1c(=O)oc2cc([C@H](Br)C3C(C)(C)C3(C)C)ccc21,4.249700000000003
+185787,Optimize the molecule CN1CCO[C@@H](CNC(=O)CC[C@H]([NH3+])c2ccccc2)C1 to have a lower LogP value.,CN1CCO[C@@H](CNC(=O)CC[C@H]([NH3+])c2ccccc2)C1,0.19660000000000277
+168629,Optimize the molecule CCCCCC(=O)Nc1cccc(-c2nn3c(CC)nnc3s2)c1 to have a higher LogP value.,CCCCCC(=O)Nc1cccc(-c2nn3c(CC)nnc3s2)c1,3.934000000000003
+23332,Please optimize the molecule CCCOc1cc(N2CCN(C(=O)C(C)C)CC2)nc(C)n1 to have a lower LogP value.,CCCOc1cc(N2CCN(C(=O)C(C)C)CC2)nc(C)n1,1.87842
+202279,Modify the molecule CC[C@@H](CC#N)N[C@@H]1CC[NH2+]C1 to have a lower LogP value.,CC[C@@H](CC#N)N[C@@H]1CC[NH2+]C1,-0.39601999999999915
+151359,Optimize the molecule O=C(Nc1n[nH]c2ccc([N+](=O)[O-])cc12)[C@H]1CC(=O)N(CC2CC2)C1 to have a higher LogP value.,O=C(Nc1n[nH]c2ccc([N+](=O)[O-])cc12)[C@H]1CC(=O)N(CC2CC2)C1,1.6680999999999997
+194962,Optimize the molecule CCCC[C@H](C)n1c([C@H](C)Cl)nc2c(CCC)nn(C)c21 to have a higher LogP value.,CCCC[C@H](C)n1c([C@H](C)Cl)nc2c(CCC)nn(C)c21,4.773300000000004
+19535,Modify the molecule CN(C)C(=O)C[NH+]1CCCN(C(=O)c2ccc(-n3cccc3)cc2)CC1 to have a lower LogP value.,CN(C)C(=O)C[NH+]1CCCN(C(=O)c2ccc(-n3cccc3)cc2)CC1,0.2963000000000027
+8390,Please modify the molecule O=C(Nc1ccc2c(c1)OCCCO2)c1ccc([N+](=O)[O-])o1 to decrease its LogP value.,O=C(Nc1ccc2c(c1)OCCCO2)c1ccc([N+](=O)[O-])o1,2.601400000000001
+172856,Modify the molecule CC1(C)C(C(=O)N2CCN(c3ncccc3C(N)=O)CC2)C1(C)C to have a lower LogP value.,CC1(C)C(C(=O)N2CCN(c3ncccc3C(N)=O)CC2)C1(C)C,1.5112999999999999
+148899,Modify the molecule Cc1ncsc1[C@H](C)N[C@@H]1CCC[C@@H]1c1ccc(F)cc1 to have a higher LogP value.,Cc1ncsc1[C@H](C)N[C@@H]1CCC[C@@H]1c1ccc(F)cc1,4.577520000000004
+240138,Please optimize the molecule CCOc1cc(C#N)ccc1OC(=O)Cc1cn2ccsc2n1 to have a lower LogP value.,CCOc1cc(C#N)ccc1OC(=O)Cc1cn2ccsc2n1,2.814280000000001
+170531,Optimize the molecule CCOC(=O)[C@H]1CCCN(c2ncnc(N3CCOCC3)c2N)C1 to have a lower LogP value.,CCOC(=O)[C@H]1CCCN(c2ncnc(N3CCOCC3)c2N)C1,0.6749000000000004
+158811,Modify the molecule COc1cccc(OC)c1C(=O)N1CCN(Cc2csc(-c3ccccc3)n2)CC1 to decrease its LogP value.,COc1cccc(OC)c1C(=O)N1CCN(Cc2csc(-c3ccccc3)n2)CC1,3.785300000000003
+172120,Modify the molecule Cc1cc(NC(=O)C(=O)N[C@H](C)[C@@H]2CCCO2)ccc1OC(C)C to decrease its LogP value.,Cc1cc(NC(=O)C(=O)N[C@H](C)[C@@H]2CCCO2)ccc1OC(C)C,2.40442
+141406,Please optimize the molecule CC(C)[NH+](Cc1cc(F)ccc1Br)C1CCOCC1 to have a higher LogP value.,CC(C)[NH+](Cc1cc(F)ccc1Br)C1CCOCC1,2.5605
+196293,Please modify the molecule CC(C)C[C@H]1NC(=O)OC1(c1ccccc1)c1ccccc1 to increase its LogP value.,CC(C)C[C@H]1NC(=O)OC1(c1ccccc1)c1ccccc1,4.084700000000003
+117849,Modify the molecule CNc1ncnc2c1[nH]c1ccccc12 to increase its LogP value.,CNc1ncnc2c1[nH]c1ccccc12,2.1528
+121842,Modify the molecule CCCCNC(=O)c1ccc(-n2cncn2)c([N+](=O)[O-])c1 to have a higher LogP value.,CCCCNC(=O)c1ccc(-n2cncn2)c([N+](=O)[O-])c1,1.7053999999999998
+5437,Please modify the molecule CCN1C(=O)/C(=C/c2c(C)c(C#N)c(=O)n(C)c2N2CCCC2)SC1=S to decrease its LogP value.,CCN1C(=O)/C(=C/c2c(C)c(C#N)c(=O)n(C)c2N2CCCC2)SC1=S,2.3867000000000003
+91016,Please modify the molecule CN(c1ccc(C(=O)[O-])cc1[N+](=O)[O-])C1CC1 to increase its LogP value.,CN(c1ccc(C(=O)[O-])cc1[N+](=O)[O-])C1CC1,0.5568999999999997
+153207,Please optimize the molecule C[C@H](NC(=O)N(C)C1CCC1)c1ccc(N2CCOCC2)cc1 to have a lower LogP value.,C[C@H](NC(=O)N(C)C1CCC1)c1ccc(N2CCOCC2)cc1,2.778100000000001
+198435,Modify the molecule Cc1ncccc1-c1nn(C)c(N)c1-c1cccc(Cl)c1 to increase its LogP value.,Cc1ncccc1-c1nn(C)c(N)c1-c1cccc(Cl)c1,3.6931200000000013
+88843,Please modify the molecule CCS(=O)(=O)NC[C@H](C)Oc1ccccc1 to increase its LogP value.,CCS(=O)(=O)NC[C@H](C)Oc1ccccc1,1.3931999999999998
+177794,Modify the molecule Cc1cc(C)n(-c2cc(N3CCC[C@@H](C(=O)Nc4ccc(Br)c(C)c4)C3)ncn2)n1 to increase its LogP value.,Cc1cc(C)n(-c2cc(N3CCC[C@@H](C(=O)Nc4ccc(Br)c(C)c4)C3)ncn2)n1,4.205160000000003
+60349,Please modify the molecule O=C(COC(=O)Cc1ccccc1)Nc1ccc(F)cc1 to increase its LogP value.,O=C(COC(=O)Cc1ccccc1)Nc1ccc(F)cc1,2.5501000000000005
+198819,Optimize the molecule Cc1ccc2c(c1)C1(OCCO1)C(=O)N2CCCOc1ccc2ccccc2c1 to have a higher LogP value.,Cc1ccc2c(c1)C1(OCCO1)C(=O)N2CCCOc1ccc2ccccc2c1,4.163520000000004
+149990,Modify the molecule Cc1ccc(CN2CCN(c3cc(C4CC[NH2+]CC4)nc(C)n3)CC2=O)cc1 to have a higher LogP value.,Cc1ccc(CN2CCN(c3cc(C4CC[NH2+]CC4)nc(C)n3)CC2=O)cc1,1.38304
+23357,Please modify the molecule O=C(COC(=O)c1ccccc1Br)c1ccc(Br)cc1 to decrease its LogP value.,O=C(COC(=O)c1ccccc1Br)c1ccc(Br)cc1,4.251300000000002
+9004,Optimize the molecule CCOC(=O)C1=C(C)N=C2C[C@@H](C)[C@H](C(=O)OC)C(=O)[C@@H]2[C@H]1c1ccc(C)cc1 to have a higher LogP value.,CCOC(=O)C1=C(C)N=C2C[C@@H](C)[C@H](C(=O)OC)C(=O)[C@@H]2[C@H]1c1ccc(C)cc1,3.3846200000000026
+135288,Modify the molecule Cc1[nH+]cn(C[C@H](C)NCc2nc(C(F)(F)F)cs2)c1C to have a lower LogP value.,Cc1[nH+]cn(C[C@H](C)NCc2nc(C(F)(F)F)cs2)c1C,2.5726400000000007
+206668,Modify the molecule COC(=O)c1ccc(CNC(=O)NC[C@H]2COc3ccccc3O2)cc1 to decrease its LogP value.,COC(=O)c1ccc(CNC(=O)NC[C@H]2COc3ccccc3O2)cc1,2.112399999999999
+31358,Modify the molecule COc1ccc(/C=N/c2cccc([N+](=O)[O-])c2C)c2ccccc12 to increase its LogP value.,COc1ccc(/C=N/c2cccc([N+](=O)[O-])c2C)c2ccccc12,4.8156200000000045
+101918,Please optimize the molecule O=S(=O)(c1ccccc1)n1ccc2ccc(Br)nc21 to have a lower LogP value.,O=S(=O)(c1ccccc1)n1ccc2ccc(Br)nc21,3.035800000000002
+102922,Please modify the molecule CC(C)(C(=O)N1CCn2c(nnc2C(F)(F)F)C1)c1cccc(C#N)c1 to increase its LogP value.,CC(C)(C(=O)N1CCn2c(nnc2C(F)(F)F)C1)c1cccc(C#N)c1,2.4885800000000007
+140428,Modify the molecule CSCC[NH+](C)[C@@H](C)C(=O)Nc1c(C)cccc1C to have a higher LogP value.,CSCC[NH+](C)[C@@H](C)C(=O)Nc1c(C)cccc1C,1.5081399999999998
+153812,Please modify the molecule Cc1ccc(Nc2cnn(C)c2)cc1N to increase its LogP value.,Cc1ccc(Nc2cnn(C)c2)cc1N,2.0543199999999997
+3775,Modify the molecule CCN(CC)c1ccc([C@@H]2C3=C([O-])CCCC3=NC3=NC(SC)=NC(=O)[C@@H]32)cc1 to have a higher LogP value.,CCN(CC)c1ccc([C@@H]2C3=C([O-])CCCC3=NC3=NC(SC)=NC(=O)[C@@H]32)cc1,3.143200000000002
+189246,Modify the molecule C[C@H]1CCC[C@H](C)N(C(=O)c2ccc(S(N)(=O)=O)c(F)c2)C1 to have a higher LogP value.,C[C@H]1CCC[C@H](C)N(C(=O)c2ccc(S(N)(=O)=O)c(F)c2)C1,2.1238
+226847,Optimize the molecule CCOc1cc(C[NH+]2CCC[C@@H](COC)C2)cc(Cl)c1OC to have a lower LogP value.,CCOc1cc(C[NH+]2CCC[C@@H](COC)C2)cc(Cl)c1OC,2.1886
+169316,Modify the molecule Clc1ccc(C[NH2+]C[C@H]2CN3CCCC[C@@H]3CO2)o1 to decrease its LogP value.,Clc1ccc(C[NH2+]C[C@H]2CN3CCCC[C@@H]3CO2)o1,1.2496999999999994
+155889,Optimize the molecule N[C@@H](c1cccc(F)c1F)[C@H]1CSCCO1 to have a higher LogP value.,N[C@@H](c1cccc(F)c1F)[C@H]1CSCCO1,2.0966
+192610,Optimize the molecule CC[C@@H](C[NH3+])C(=O)N1CCO[C@H](C#N)C1 to have a lower LogP value.,CC[C@@H](C[NH3+])C(=O)N1CCO[C@H](C#N)C1,-0.9945199999999985
+228536,Optimize the molecule CCN(CC)S(=O)(=O)c1ccc(NC(=O)c2cn(CC)c3ccc(F)cc3c2=O)cc1 to have a lower LogP value.,CCN(CC)S(=O)(=O)c1ccc(NC(=O)c2cn(CC)c3ccc(F)cc3c2=O)cc1,3.4433000000000025
+15985,Please modify the molecule C[C@H]1CCc2c(C(=O)NCc3ccc(S(N)(=O)=O)cc3)csc2C1 to decrease its LogP value.,C[C@H]1CCc2c(C(=O)NCc3ccc(S(N)(=O)=O)cc3)csc2C1,2.4503000000000004
+32981,Please modify the molecule O=c1/c(=C/c2cccc([N+](=O)[O-])c2)sc2nc(/C=C/c3ccc(F)cc3)nn12 to decrease its LogP value.,O=c1/c(=C/c2cccc([N+](=O)[O-])c2)sc2nc(/C=C/c3ccc(F)cc3)nn12,2.916400000000001
+123071,Optimize the molecule CC(=O)N[C@@H](CC(=O)Nc1cccc(C2=NN=CC2)c1)c1cccs1 to have a lower LogP value.,CC(=O)N[C@@H](CC(=O)Nc1cccc(C2=NN=CC2)c1)c1cccs1,3.1327000000000016
+206808,Please optimize the molecule COC(=O)c1cc(NC(=O)/C=C/c2ccco2)cc(C(=O)OC)c1 to have a lower LogP value.,COC(=O)c1cc(NC(=O)/C=C/c2ccco2)cc(C(=O)OC)c1,2.5047000000000006
+139641,Modify the molecule Cc1cc(F)ccc1CCNC(=O)c1ccc(CS(C)(=O)=O)cc1 to increase its LogP value.,Cc1cc(F)ccc1CCNC(=O)c1ccc(CS(C)(=O)=O)cc1,2.6512200000000012
+72678,Modify the molecule C[C@@H](C#N)Oc1ccc(/C=C(/C#N)c2nc(-c3ccncc3)cs2)cc1 to decrease its LogP value.,C[C@@H](C#N)Oc1ccc(/C=C(/C#N)c2nc(-c3ccncc3)cs2)cc1,4.560160000000002
+78050,Modify the molecule Cn1ncnc1C[NH+](C)CC(=O)NCc1ccc2c(c1)OCO2 to increase its LogP value.,Cn1ncnc1C[NH+](C)CC(=O)NCc1ccc2c(c1)OCO2,-1.1250999999999978
+134523,Please modify the molecule O=S(=O)(NCCc1csc(-n2cccn2)n1)c1cc(F)cc(F)c1 to decrease its LogP value.,O=S(=O)(NCCc1csc(-n2cccn2)n1)c1cc(F)cc(F)c1,2.128
+127576,Optimize the molecule Cc1cc(C(=O)Nc2cccc(NS(N)(=O)=O)c2)ccc1F to have a lower LogP value.,Cc1cc(C(=O)Nc2cccc(NS(N)(=O)=O)c2)ccc1F,2.0018200000000004
+130307,Modify the molecule COCCNC(=O)c1cc2cc(OC)ccc2oc1=O to have a higher LogP value.,COCCNC(=O)c1cc2cc(OC)ccc2oc1=O,1.1778
+14572,Modify the molecule CCc1nnc(NC(=O)c2cccc(C)c2C)s1 to have a lower LogP value.,CCc1nnc(NC(=O)c2cccc(C)c2C)s1,2.969640000000001
+21886,Please optimize the molecule CC1=C[C@@H](C(=O)N(C)C[C@@H]2CCC[NH+](CCc3ccc(Cl)cc3)C2)N=N1 to have a higher LogP value.,CC1=C[C@@H](C(=O)N(C)C[C@@H]2CCC[NH+](CCc3ccc(Cl)cc3)C2)N=N1,2.3740000000000006
+144895,Modify the molecule CCN(C[C@@H]1CCOC1)C(=O)c1nnn(-c2ccccc2Cl)c1C to decrease its LogP value.,CCN(C[C@@H]1CCOC1)C(=O)c1nnn(-c2ccccc2Cl)c1C,2.7277200000000006
+32361,Modify the molecule Cc1c(Cl)ccc2sc(N3CCN(C(=O)c4cc(Cl)ccc4[N+](=O)[O-])CC3)nc12 to decrease its LogP value.,Cc1c(Cl)ccc2sc(N3CCN(C(=O)c4cc(Cl)ccc4[N+](=O)[O-])CC3)nc12,4.782120000000003
+26292,Modify the molecule C[C@@H](C(=O)Nc1ccccc1Cl)n1cc(Br)cn1 to increase its LogP value.,C[C@@H](C(=O)Nc1ccccc1Cl)n1cc(Br)cn1,3.4987000000000013
+216244,Please modify the molecule Cc1cccc(Nc2nc(CC(=O)Nc3cccnc3)cs2)n1 to increase its LogP value.,Cc1cccc(Nc2nc(CC(=O)Nc3cccnc3)cs2)n1,3.1663200000000007
+150743,Modify the molecule CC(C)NC(=O)CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1 to increase its LogP value.,CC(C)NC(=O)CN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1,1.4503
+83898,Please modify the molecule Cc1cccc(CN2CCN(C(=O)CCC(=O)N(C)C)CC2)c1 to increase its LogP value.,Cc1cccc(CN2CCN(C(=O)CCC(=O)N(C)C)CC2)c1,1.5076199999999997
+193566,Please optimize the molecule CC[C@@H](c1ccccc1)c1nnc(NC(=O)Nc2ccccc2F)s1 to have a higher LogP value.,CC[C@@H](c1ccccc1)c1nnc(NC(=O)Nc2ccccc2F)s1,4.863100000000002
+180938,Modify the molecule CC1(C)CN(C(=O)CCc2nc(-c3ccco3)no2)CCO1 to have a lower LogP value.,CC1(C)CN(C(=O)CCc2nc(-c3ccco3)no2)CCO1,1.8996000000000002
+243102,Please modify the molecule C[C@H]1CN(C(=O)[C@@H]2C[C@@H]2c2cccnc2)C[C@@H]1N1CCOCC1 to increase its LogP value.,C[C@H]1CN(C(=O)[C@@H]2C[C@@H]2c2cccnc2)C[C@@H]1N1CCOCC1,1.3641999999999999
+247058,Optimize the molecule Cc1nn(C)c(C)c1NC(=O)[C@@H](C)Sc1nnc(NCc2ccco2)s1 to have a higher LogP value.,Cc1nn(C)c(C)c1NC(=O)[C@@H](C)Sc1nnc(NCc2ccco2)s1,3.212840000000001
+246917,Please optimize the molecule CCN(Cc1cnn(C)c1)S(=O)(=O)c1cccc(C(F)(F)F)c1 to have a lower LogP value.,CCN(Cc1cnn(C)c1)S(=O)(=O)c1cccc(C(F)(F)F)c1,2.649700000000001
+175322,Modify the molecule CC(C)n1ncc2cc(NC(=O)CN3C(=O)[C@@H](C)Oc4ccccc43)cnc21 to have a higher LogP value.,CC(C)n1ncc2cc(NC(=O)CN3C(=O)[C@@H](C)Oc4ccccc43)cnc21,2.764800000000001
+114191,Modify the molecule CCO[C@H]1C[C@H]([O-])C12CC[NH+]([C@@H]1CC[C@H](C)C1)CC2 to have a higher LogP value.,CCO[C@H]1C[C@H]([O-])C12CC[NH+]([C@@H]1CC[C@H](C)C1)CC2,0.3778000000000019
+9792,Please modify the molecule CCCC(=O)N1CCN(c2nc3c(c(=O)[nH]c(=O)n3C)n2Cc2ccc(C)cc2)CC1 to increase its LogP value.,CCCC(=O)N1CCN(c2nc3c(c(=O)[nH]c(=O)n3C)n2Cc2ccc(C)cc2)CC1,1.2287200000000007
+68384,Modify the molecule Cc1n[nH]c(C)c1NC(=O)Nc1ccc(F)cc1C(F)(F)F to increase its LogP value.,Cc1n[nH]c(C)c1NC(=O)Nc1ccc(F)cc1C(F)(F)F,3.8284400000000014
+126860,Modify the molecule CCCOc1cc(C)ccc1NC(=O)N[C@@H]1CCC[C@@H](S(C)(=O)=O)C1 to decrease its LogP value.,CCCOc1cc(C)ccc1NC(=O)N[C@@H]1CCC[C@@H](S(C)(=O)=O)C1,3.261120000000002
+47060,Modify the molecule OC[C@]1(Cc2ccccc2)CCC[NH+](Cc2cc(Cl)ccc2O)C1 to increase its LogP value.,OC[C@]1(Cc2ccccc2)CCC[NH+](Cc2cc(Cl)ccc2O)C1,2.4457000000000004
+145504,Optimize the molecule CCN[C@]1(C#N)CC[C@@H]([NH+]2CCC[C@H](OCC)C2)C1 to have a lower LogP value.,CCN[C@]1(C#N)CC[C@@H]([NH+]2CCC[C@H](OCC)C2)C1,0.49458000000000113
+13764,Optimize the molecule Cc1cc(OCC(=O)N(Cc2ccc(C(C)C)cc2)[C@@H]2CCS(=O)(=O)C2)ccc1Cl to have a lower LogP value.,Cc1cc(OCC(=O)N(Cc2ccc(C(C)C)cc2)[C@@H]2CCS(=O)(=O)C2)ccc1Cl,4.366520000000004
+249338,Modify the molecule CC[C@H](C)CN(C)C(=O)NCc1cccc(NC(C)=O)c1 to have a higher LogP value.,CC[C@H](C)CN(C)C(=O)NCc1cccc(NC(C)=O)c1,2.8325000000000014
+8974,Modify the molecule O=C(Cn1cnc2ccc([N+](=O)[O-])cc2c1=O)N1CCN(c2ccc(F)cc2)CC1 to have a higher LogP value.,O=C(Cn1cnc2ccc([N+](=O)[O-])cc2c1=O)N1CCN(c2ccc(F)cc2)CC1,1.7926000000000002
+246606,Modify the molecule CC1=C(C#N)c2nc(N)c(C#N)c(C)c2/C1=C/c1ccc(-c2ccc(C(=O)[O-])cc2)o1 to have a higher LogP value.,CC1=C(C#N)c2nc(N)c(C#N)c(C)c2/C1=C/c1ccc(-c2ccc(C(=O)[O-])cc2)o1,3.3186800000000023
+229566,Modify the molecule CC[NH+](CC)Cc1ccccc1CNC(=O)N1CCOCC1 to decrease its LogP value.,CC[NH+](CC)Cc1ccccc1CNC(=O)N1CCOCC1,0.6531000000000002
+37782,Modify the molecule COc1ccccc1N1CCN(C(=O)c2ccc(O)c(C)c2)CC1=O to decrease its LogP value.,COc1ccccc1N1CCN(C(=O)c2ccc(O)c(C)c2)CC1=O,2.19822
+114513,Modify the molecule Cc1cc(CN2CCCN(c3ncccn3)CC2)c(C)n1C1CC1 to have a higher LogP value.,Cc1cc(CN2CCCN(c3ncccn3)CC2)c(C)n1C1CC1,2.942140000000001
+50734,Modify the molecule COc1ccc(/C=C2\Oc3cc(OC(=O)[C@H]4CCCO4)ccc3C2=O)c(OC)c1OC to decrease its LogP value.,COc1ccc(/C=C2\Oc3cc(OC(=O)[C@H]4CCCO4)ccc3C2=O)c(OC)c1OC,3.413000000000002
+217237,Modify the molecule CC[C@@H]1CCCCN1C(=O)CSc1nnc(-c2cccs2)n1-c1ccccc1OC to have a lower LogP value.,CC[C@@H]1CCCCN1C(=O)CSc1nnc(-c2cccs2)n1-c1ccccc1OC,4.887600000000004
+67628,Please modify the molecule COc1cccc(C(=O)Nc2ccc(NC(=O)c3ccc(Cl)cc3)cc2)c1 to increase its LogP value.,COc1cccc(C(=O)Nc2ccc(NC(=O)c3ccc(Cl)cc3)cc2)c1,4.853200000000003
+219350,Please optimize the molecule Cc1nc(CNC(=O)Nc2ccc(OC(C)C)c(C)c2)c(C)s1 to have a higher LogP value.,Cc1nc(CNC(=O)Nc2ccc(OC(C)C)c(C)c2)c(C)s1,4.177260000000003
+49936,Modify the molecule CC[C@](C)(CCN(C(C)=O)[C@H]1CCOC(C)(C)C1)c1ccccc1 to increase its LogP value.,CC[C@](C)(CCN(C(C)=O)[C@H]1CCOC(C)(C)C1)c1ccccc1,4.550500000000004
+117742,Modify the molecule CCCN(CC(=O)N1CCc2sccc2[C@@H]1c1ccccc1)C(=O)C1CCCC1 to have a lower LogP value.,CCCN(CC(=O)N1CCc2sccc2[C@@H]1c1ccccc1)C(=O)C1CCCC1,4.651000000000004
+68420,Modify the molecule CCc1cc(CNC(=O)c2cccc3[nH]ccc23)on1 to increase its LogP value.,CCc1cc(CNC(=O)c2cccc3[nH]ccc23)on1,2.6483
+67134,Optimize the molecule CC(C)(CNC(=O)[C@H]1CCCN1C(=O)OCC(F)(F)F)c1ccncc1 to have a higher LogP value.,CC(C)(CNC(=O)[C@H]1CCCN1C(=O)OCC(F)(F)F)c1ccncc1,2.6387
+132132,Modify the molecule CCCC(=O)OC[C@H](O)CN1CCOCC1 to have a higher LogP value.,CCCC(=O)OC[C@H](O)CN1CCOCC1,0.02279999999999993
+118376,Modify the molecule O=C(c1csc(Nc2ccc(OC(F)F)cc2)n1)N1CCCC1 to have a higher LogP value.,O=C(c1csc(Nc2ccc(OC(F)F)cc2)n1)N1CCCC1,3.7241000000000026
+160067,Optimize the molecule COC(=O)[C@@H](C)[C@@H](NC(=O)Cc1c[nH]c2cc(F)ccc12)c1ccccc1 to have a higher LogP value.,COC(=O)[C@@H](C)[C@@H](NC(=O)Cc1c[nH]c2cc(F)ccc12)c1ccccc1,3.5161000000000016
+128724,Please optimize the molecule COc1ccc(-c2n[nH]cc2C[NH2+]C2CC2)cc1 to have a lower LogP value.,COc1ccc(-c2n[nH]cc2C[NH2+]C2CC2)cc1,1.3110999999999997
+181990,Optimize the molecule COCCN1C(=O)C([O-])=C(C(=O)c2cc(C)ccc2C)[C@@H]1c1cccc(OC)c1 to have a lower LogP value.,COCCN1C(=O)C([O-])=C(C(=O)c2cc(C)ccc2C)[C@@H]1c1cccc(OC)c1,2.33904
+167692,Modify the molecule c1csc(-c2csc(C[NH2+]C[C@@H]3CCc4nncn4C3)c2)c1 to have a lower LogP value.,c1csc(-c2csc(C[NH2+]C[C@@H]3CCc4nncn4C3)c2)c1,2.394100000000001
+203947,Modify the molecule COc1ccc(-c2nc3c4cnn(-c5ccc(C)cc5C)c4ncn3n2)c(O)c1 to increase its LogP value.,COc1ccc(-c2nc3c4cnn(-c5ccc(C)cc5C)c4ncn3n2)c(O)c1,3.461240000000001
+199191,Optimize the molecule Cc1csc(CCNc2ncnc3sc4c(c23)CC[C@@H](C)C4)n1 to have a lower LogP value.,Cc1csc(CCNc2ncnc3sc4c(c23)CC[C@@H](C)C4)n1,4.2356200000000035
+94378,Modify the molecule COc1ccc([C@H](CNC(=O)c2ccccc2S(C)(=O)=O)[NH+](C)C)cc1 to have a higher LogP value.,COc1ccc([C@H](CNC(=O)c2ccccc2S(C)(=O)=O)[NH+](C)C)cc1,0.7143000000000008
+117391,Modify the molecule COc1ccc2[nH]c(C)c(CCNC(=C3C(=O)N(C)C(=O)N(C)C3=O)c3ccc(Cl)cc3)c2c1 to have a higher LogP value.,COc1ccc2[nH]c(C)c(CCNC(=C3C(=O)N(C)C(=O)N(C)C3=O)c3ccc(Cl)cc3)c2c1,3.732120000000002
+149484,Modify the molecule CNC(=O)CC1CCN(C(=O)NC[C@H](C)Cc2cccs2)CC1 to increase its LogP value.,CNC(=O)CC1CCN(C(=O)NC[C@H](C)Cc2cccs2)CC1,2.4844
+133390,Please optimize the molecule O=C(OCc1ccccn1)c1cn(-c2cccc(F)c2)c(=O)c2ccccc12 to have a lower LogP value.,O=C(OCc1ccccn1)c1cn(-c2cccc(F)c2)c(=O)c2ccccc12,3.881800000000003
+207554,Modify the molecule C[C@H]1OCC[C@H]1C(=O)N(Cc1ccccc1F)c1ccc(F)cc1 to increase its LogP value.,C[C@H]1OCC[C@H]1C(=O)N(Cc1ccccc1F)c1ccc(F)cc1,3.9230000000000027
+52640,Please optimize the molecule Cc1ccccc1NC(=O)[C@@H](C)Sc1nnnn1Cc1ccccc1 to have a higher LogP value.,Cc1ccccc1NC(=O)[C@@H](C)Sc1nnnn1Cc1ccccc1,3.1491200000000017
+239954,Please modify the molecule Oc1cccc(C[C@@H](O)c2ccc(OC(F)(F)F)cc2)c1 to decrease its LogP value.,Oc1cccc(C[C@@H](O)c2ccc(OC(F)(F)F)cc2)c1,3.5669000000000013
+220691,Please optimize the molecule CCN(C(=O)c1ccc(SC)nc1)c1ccc(C)cc1C to have a lower LogP value.,CCN(C(=O)c1ccc(SC)nc1)c1ccc(C)cc1C,4.087040000000003
+87015,Optimize the molecule CCC(=O)Nc1ccccc1-c1nc2ccccc2n([C@@H](C)C(=O)Nc2cccc(C#N)c2)c1=O to have a higher LogP value.,CCC(=O)Nc1ccccc1-c1nc2ccccc2n([C@@H](C)C(=O)Nc2cccc(C#N)c2)c1=O,4.483380000000002
+68289,Modify the molecule Clc1ccc(CC[NH2+]C(C2CC2)C2CC2)cc1 to have a lower LogP value.,Clc1ccc(CC[NH2+]C(C2CC2)C2CC2)cc1,2.634500000000001
+167501,Please optimize the molecule Cc1cccc([C@@H](CCC[C@@H]2CCCO2)C(=O)[O-])c1 to have a higher LogP value.,Cc1cccc([C@@H](CCC[C@@H]2CCCO2)C(=O)[O-])c1,2.1778199999999996
+35805,Please optimize the molecule COc1ccc(C(=O)NCC(=O)N/N=C/c2ccc([N+](=O)[O-])s2)cc1 to have a lower LogP value.,COc1ccc(C(=O)NCC(=O)N/N=C/c2ccc([N+](=O)[O-])s2)cc1,1.545
+25977,Please optimize the molecule O=C(COc1cccc(Cl)c1)Nc1ccccc1[N+](=O)[O-] to have a higher LogP value.,O=C(COc1cccc(Cl)c1)Nc1ccccc1[N+](=O)[O-],3.2657000000000007
+122701,Modify the molecule O=C(Cc1cccs1)N1CCc2nocc2C1 to have a lower LogP value.,O=C(Cc1cccs1)N1CCc2nocc2C1,1.8635
+213186,Modify the molecule Cc1ccc(C(=O)NC[C@H](C)Cn2nc(C)cc2C)cn1 to have a lower LogP value.,Cc1ccc(C(=O)NC[C@H](C)Cn2nc(C)cc2C)cn1,2.2694600000000005
+111867,Modify the molecule O=C(C[NH+]1CCC[C@H](C(=O)NCC(F)(F)F)C1)Nc1cccnc1 to have a lower LogP value.,O=C(C[NH+]1CCC[C@H](C(=O)NCC(F)(F)F)C1)Nc1cccnc1,-0.006500000000000117
+27450,Optimize the molecule CN[C@@H](c1ccccc1C)C1([NH+]2CCCC2)CCCC1 to have a higher LogP value.,CN[C@@H](c1ccccc1C)C1([NH+]2CCCC2)CCCC1,2.24702
+169059,Modify the molecule c1cc2c(cc1Cc1nn3c(CN4CCOCC4)nnc3s1)CCCC2 to decrease its LogP value.,c1cc2c(cc1Cc1nn3c(CN4CCOCC4)nnc3s1)CCCC2,2.4876000000000005
+203892,Please modify the molecule CCCn1c(-c2cccc(C)c2)nnc1S(C)(=O)=O to decrease its LogP value.,CCCn1c(-c2cccc(C)c2)nnc1S(C)(=O)=O,2.0670199999999994
+221782,Optimize the molecule CC(=O)N(C)c1cccc(NC(=O)C[C@@H](O)c2ccccc2)c1 to have a lower LogP value.,CC(=O)N(C)c1cccc(NC(=O)C[C@@H](O)c2ccccc2)c1,2.7315000000000014
+210958,Modify the molecule C[NH+](C)CCSc1nc(-c2ccccc2)c[nH]1 to have a lower LogP value.,C[NH+](C)CCSc1nc(-c2ccccc2)c[nH]1,1.3133000000000001
+246858,Optimize the molecule COC(=O)c1sccc1NC(=O)c1ccc(O)cc1 to have a higher LogP value.,COC(=O)c1sccc1NC(=O)c1ccc(O)cc1,2.4926000000000004
+175529,Please optimize the molecule CC(C)(Cc1cccc(Cl)c1)C(=O)NCc1cc(=O)[nH]c2ccccc12 to have a higher LogP value.,CC(C)(Cc1cccc(Cl)c1)C(=O)NCc1cc(=O)[nH]c2ccccc12,4.066600000000002
+70164,Modify the molecule CCn1ncc(Br)c1C(=O)N1CCC[C@H](C)C1 to have a lower LogP value.,CCn1ncc(Br)c1C(=O)N1CCC[C@H](C)C1,2.537600000000001
+172951,Modify the molecule O=C(/C=C/c1nc2ccccc2s1)Nc1ccc(Cl)cc1 to increase its LogP value.,O=C(/C=C/c1nc2ccccc2s1)Nc1ccc(Cl)cc1,4.601600000000002
+98190,Modify the molecule O=C(Nc1ccc2c(c1)CCC2)[C@@H]1CCCN1S(=O)(=O)c1ccc(Cl)s1 to have a higher LogP value.,O=C(Nc1ccc2c(c1)CCC2)[C@@H]1CCCN1S(=O)(=O)c1ccc(Cl)s1,3.682000000000003
+61880,Modify the molecule Cc1ccc([N+](=O)[O-])cc1NC(=O)C(=O)NC[C@@H](c1cccn1C)[NH+]1CCOCC1 to decrease its LogP value.,Cc1ccc([N+](=O)[O-])cc1NC(=O)C(=O)NC[C@@H](c1cccn1C)[NH+]1CCOCC1,-0.04717999999999889
+128691,Please modify the molecule CC(=O)c1ccc(NC(=O)NC[C@H]2CCC[C@@H]2O)cc1C to decrease its LogP value.,CC(=O)c1ccc(NC(=O)NC[C@H]2CCC[C@@H]2O)cc1C,2.4801200000000003
+155130,Optimize the molecule CCOc1ccccc1/C=C(\NC(=O)c1ccccc1)C(=O)Nc1cccc(O)c1 to have a higher LogP value.,CCOc1ccccc1/C=C(\NC(=O)c1ccccc1)C(=O)Nc1cccc(O)c1,4.2005000000000035
+20931,Please modify the molecule COc1cc(/C=N/NC(=O)[C@H](C)Oc2ccc3ccccc3c2)ccc1O to decrease its LogP value.,COc1cc(/C=N/NC(=O)[C@H](C)Oc2ccc3ccccc3c2)ccc1O,3.4716000000000027
+142356,Modify the molecule CCNS(=O)(=O)[C@H]1CCN(C(=O)NCCc2sc(C)nc2C)C1 to increase its LogP value.,CCNS(=O)(=O)[C@H]1CCN(C(=O)NCCc2sc(C)nc2C)C1,1.0256399999999997
+204345,Optimize the molecule Cc1cccc(C(=O)Nc2ccnc(-c3ccccc3)n2)c1F to have a higher LogP value.,Cc1cccc(C(=O)Nc2ccnc(-c3ccccc3)n2)c1F,3.843420000000002
+172876,Please modify the molecule CCCn1ccnc1-c1nc(Cl)ncc1F to increase its LogP value.,CCCn1ccnc1-c1nc(Cl)ncc1F,2.5426
+191960,Please optimize the molecule O=C(Nc1ccc(Oc2ccccc2)cc1)N1CCN(C(=O)c2ccco2)CC1 to have a higher LogP value.,O=C(Nc1ccc(Oc2ccccc2)cc1)N1CCN(C(=O)c2ccco2)CC1,4.0618000000000025
+146353,Please optimize the molecule C[C@H](CC(=O)NCC(C)(C)c1ccncc1)c1ccccc1 to have a lower LogP value.,C[C@H](CC(=O)NCC(C)(C)c1ccncc1)c1ccccc1,3.6692000000000027
+142429,Please modify the molecule O=C(Nc1ccc(N2C(=O)CCCC2=O)cc1)[C@@H]1CCOc2ccccc21 to increase its LogP value.,O=C(Nc1ccc(N2C(=O)CCCC2=O)cc1)[C@@H]1CCOc2ccccc21,3.2349000000000023
+74502,Optimize the molecule CCCn1nc(C(=O)N2CCSCC2)c2c1CC[C@@H]([NH+](C)CCOC)C2 to have a lower LogP value.,CCCn1nc(C(=O)N2CCSCC2)c2c1CC[C@@H]([NH+](C)CCOC)C2,0.5005000000000026
+15476,Modify the molecule C[C@H](Sc1nnnn1C1CC1)C(=O)Nc1cncc2ccccc12 to decrease its LogP value.,C[C@H](Sc1nnnn1C1CC1)C(=O)Nc1cncc2ccccc12,2.6755000000000004
+18095,Modify the molecule ClCc1cncc(Oc2ccc(Cl)c3ccccc23)n1 to have a lower LogP value.,ClCc1cncc(Oc2ccc(Cl)c3ccccc23)n1,4.814300000000003
+43969,Please modify the molecule CC1(C)CC(=O)C2=C(C1)NC1=NC(SCc3ccccc3)=NC(=O)[C@@H]1[C@H]2c1ccncc1 to increase its LogP value.,CC1(C)CC(=O)C2=C(C1)NC1=NC(SCc3ccccc3)=NC(=O)[C@@H]1[C@H]2c1ccncc1,4.255900000000003
+41758,Modify the molecule C[C@H](NC(=O)C[NH+]1CC[C@H](C)[C@@H](O)C1)c1ccc2ccccc2c1 to increase its LogP value.,C[C@H](NC(=O)C[NH+]1CC[C@H](C)[C@@H](O)C1)c1ccc2ccccc2c1,1.302600000000001
+102340,Optimize the molecule O=c1[nH]c2ccccc2nc1CN1CCOCC1 to have a lower LogP value.,O=c1[nH]c2ccccc2nc1CN1CCOCC1,0.7552999999999999
+231663,Please modify the molecule CC(C)C[C@@H]1NC(=O)N(CCN2CCOCC2)C1=O to increase its LogP value.,CC(C)C[C@@H]1NC(=O)N(CCN2CCOCC2)C1=O,0.2851000000000006
+65995,Modify the molecule CNC(=O)[C@H]1Cc2ccccc2C[NH+]1Cc1nc(-c2ccccc2)no1 to have a higher LogP value.,CNC(=O)[C@H]1Cc2ccccc2C[NH+]1Cc1nc(-c2ccccc2)no1,0.9923999999999997
+209697,Please optimize the molecule CCN(Cc1cccs1)CN1C(=O)N[C@](CC)(c2ccccc2)C1=O to have a lower LogP value.,CCN(Cc1cccs1)CN1C(=O)N[C@](CC)(c2ccccc2)C1=O,3.384800000000002
+173098,Optimize the molecule COCCN1C[C@@H](C(=O)NC2CCC(C)CC2)CC1=O to have a lower LogP value.,COCCN1C[C@@H](C(=O)NC2CCC(C)CC2)CC1=O,1.1762
+113718,Please modify the molecule Cc1nnc(-c2ccc(C(=O)N(C)[C@@H](C)CNC(=O)OC(C)(C)C)cc2)o1 to decrease its LogP value.,Cc1nnc(-c2ccc(C(=O)N(C)[C@@H](C)CNC(=O)OC(C)(C)C)cc2)o1,3.0302200000000017
+142799,Please modify the molecule COc1ccc(CNC(=O)c2cc(S(=O)(=O)NC(C)(C)C)ccc2C)cc1 to decrease its LogP value.,COc1ccc(CNC(=O)c2cc(S(=O)(=O)NC(C)(C)C)ccc2C)cc1,3.0104200000000017
+218895,Please optimize the molecule CCOc1cc([N+](=O)[O-])c(C(=O)N2CCCc3cccc(C)c32)cc1OC to have a lower LogP value.,CCOc1cc([N+](=O)[O-])c(C(=O)N2CCCc3cccc(C)c32)cc1OC,3.903520000000003
+248116,Please modify the molecule OC[C@H]1CC[NH+](Cc2cccc(OCc3ccccc3F)c2)C1 to decrease its LogP value.,OC[C@H]1CC[NH+](Cc2cccc(OCc3ccccc3F)c2)C1,1.8017999999999994
+162756,Please optimize the molecule CC(C)c1cc(N2C[C@H](C(N)=O)CC[C@H]2C)nc(C(C)C)[nH+]1 to have a lower LogP value.,CC(C)c1cc(N2C[C@H](C(N)=O)CC[C@H]2C)nc(C(C)C)[nH+]1,2.2327
+177038,Optimize the molecule CC1CC[NH+]([C@H](C)CNC(=O)C(C)(C)Oc2ccc(Cl)cc2)CC1 to have a higher LogP value.,CC1CC[NH+]([C@H](C)CNC(=O)C(C)(C)Oc2ccc(Cl)cc2)CC1,2.3169000000000004
+177422,Please optimize the molecule COCC(=O)N1CCC[C@@H]1c1cccc(Cc2ccccc2)n1 to have a lower LogP value.,COCC(=O)N1CCC[C@@H]1c1cccc(Cc2ccccc2)n1,2.9823000000000013
+29811,Please optimize the molecule Cc1cccc([C@@H](C)NC(=O)c2cn(CC(N)=O)nn2)c1C to have a higher LogP value.,Cc1cccc([C@@H](C)NC(=O)c2cn(CC(N)=O)nn2)c1C,0.87124
+140680,Please modify the molecule CCNS(=O)(=O)[C@H]1CCN(C(=O)[C@H](C)c2ccc(OC)cc2)C1 to decrease its LogP value.,CCNS(=O)(=O)[C@H]1CCN(C(=O)[C@H](C)c2ccc(OC)cc2)C1,1.3388999999999993
+55385,Modify the molecule CCCCOC(=O)Cc1c(C)[nH]c(=O)[nH]c1=O to have a lower LogP value.,CCCCOC(=O)Cc1c(C)[nH]c(=O)[nH]c1=O,0.2574200000000001
+135160,Please optimize the molecule CCN(C(=O)Nc1cccnc1Cl)[C@@H](C)C(C)C to have a higher LogP value.,CCN(C(=O)Nc1cccnc1Cl)[C@@H](C)C(C)C,3.633300000000003
+162358,Optimize the molecule CC(C)C[C@@H](C)OCc1nc2ccc(N)cc2o1 to have a higher LogP value.,CC(C)C[C@@H](C)OCc1nc2ccc(N)cc2o1,3.361200000000001
+244846,Please modify the molecule C[NH2+][C@@H](c1cc(C)ccc1F)[C@H]1CN2CCC[C@@H]2CO1 to increase its LogP value.,C[NH2+][C@@H](c1cc(C)ccc1F)[C@H]1CN2CCC[C@@H]2CO1,1.2316199999999997
+214807,Modify the molecule COc1ccc(OC)c(S(=O)(=O)Nc2ccc(Oc3ccccc3)nc2)c1 to increase its LogP value.,COc1ccc(OC)c(S(=O)(=O)Nc2ccc(Oc3ccccc3)nc2)c1,3.691900000000002
+143643,Modify the molecule C[NH+]1CCCC[C@H]1CN1CCN(Cc2cnc(C3CCC3)s2)CC1 to decrease its LogP value.,C[NH+]1CCCC[C@H]1CN1CCN(Cc2cnc(C3CCC3)s2)CC1,1.5954000000000004
+38815,Please optimize the molecule CC[NH2+][C@@H](C(C)C)[C@H](C)c1cc(C)ccc1C to have a lower LogP value.,CC[NH2+][C@@H](C(C)C)[C@H](C)c1cc(C)ccc1C,3.0148400000000013
+176698,Please modify the molecule CC(C)CC[C@@]1(CC(=O)[O-])CCOC(C)(C)C1 to decrease its LogP value.,CC(C)CC[C@@]1(CC(=O)[O-])CCOC(C)(C)C1,2.138
+98582,Please optimize the molecule Cn1cc([C@H]2CN(C(=O)c3sccc3C#N)CCO2)cn1 to have a higher LogP value.,Cn1cc([C@H]2CN(C(=O)c3sccc3C#N)CCO2)cn1,1.56698
+32230,Optimize the molecule Cc1c(C(=O)OCc2nc3ccccc3o2)cnn1C(C)C to have a higher LogP value.,Cc1c(C(=O)OCc2nc3ccccc3o2)cnn1C(C)C,3.270620000000002
+222899,Modify the molecule Cc1ccc(-c2nnc(SCC(=O)Nc3ccccc3I)n2N)cc1 to have a higher LogP value.,Cc1ccc(-c2nnc(SCC(=O)Nc3ccccc3I)n2N)cc1,3.3027200000000008
+232539,Optimize the molecule OC[C@H](Nc1cccc(Br)c1)c1cccc(C2CC2)c1 to have a higher LogP value.,OC[C@H](Nc1cccc(Br)c1)c1cccc(C2CC2)c1,4.472000000000002
+96165,Optimize the molecule C#CCn1/c(=N/S(=O)(=O)c2ccc(OC)cc2)sc2cccc(F)c21 to have a lower LogP value.,C#CCn1/c(=N/S(=O)(=O)c2ccc(OC)cc2)sc2cccc(F)c21,2.7733000000000008
+107424,Optimize the molecule N#CC1=C(N)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CCC2)[C@H]1[C@@H]1C=NN=C1c1ccccc1 to have a higher LogP value.,N#CC1=C(N)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CCC2)[C@H]1[C@@H]1C=NN=C1c1ccccc1,4.947480000000003
+243859,Modify the molecule CC[C@](C)(C(=O)NC1CCCC1)N(C[C@H]1CCCO1)C(=O)c1ccc(=O)[nH]c1 to have a higher LogP value.,CC[C@](C)(C(=O)NC1CCCC1)N(C[C@H]1CCCO1)C(=O)c1ccc(=O)[nH]c1,2.2235999999999994
+164808,Please modify the molecule CCCCc1c([O-])nc(-c2ccccc2Br)oc1=O to increase its LogP value.,CCCCc1c([O-])nc(-c2ccccc2Br)oc1=O,2.8805000000000014
+107492,Please optimize the molecule Cc1nn(C)c(C)c1CCC(=O)N1CCC[C@H]1c1nc(-c2ccccc2)no1 to have a higher LogP value.,Cc1nn(C)c(C)c1CCC(=O)N1CCC[C@H]1c1nc(-c2ccccc2)no1,3.3832400000000025
+97423,Please optimize the molecule Cc1ccc([C@@H](C)NC(=O)N2CCC[C@@H](CNC(=O)C(C)(C)C)C2)cc1F to have a higher LogP value.,Cc1ccc([C@@H](C)NC(=O)N2CCC[C@@H](CNC(=O)C(C)(C)C)C2)cc1F,3.7790200000000027
+43073,Optimize the molecule C[C@H](N[C@H](C)c1nccs1)c1cc(F)ccc1N1CCC(O)CC1 to have a lower LogP value.,C[C@H](N[C@H](C)c1nccs1)c1cc(F)ccc1N1CCC(O)CC1,3.6551000000000027
+100264,Modify the molecule O=C(CCCN1C(=O)c2ccccc2N[C@@H]1O)NC1=CC2=CC=N[C@@H]2C=C1 to have a lower LogP value.,O=C(CCCN1C(=O)c2ccccc2N[C@@H]1O)NC1=CC2=CC=N[C@@H]2C=C1,1.5596999999999999
+196211,Modify the molecule O=C(NCc1ccc(F)cc1)N1CCC2(CC1)OCCN2S(=O)(=O)c1ccc(Cl)cc1 to decrease its LogP value.,O=C(NCc1ccc(F)cc1)N1CCC2(CC1)OCCN2S(=O)(=O)c1ccc(Cl)cc1,3.201900000000002
+122525,Modify the molecule CC(=O)Nc1cc(N[C@H]2CC(=O)N(c3ccc4ccccc4c3)C2=O)ccc1C to have a lower LogP value.,CC(=O)Nc1cc(N[C@H]2CC(=O)N(c3ccc4ccccc4c3)C2=O)ccc1C,3.850620000000003
+201330,Please optimize the molecule COc1cc(C)c(C(=O)N[C@@H]2CCCC2(C)C)cc1OC to have a lower LogP value.,COc1cc(C)c(C(=O)N[C@@H]2CCCC2(C)C)cc1OC,3.3207200000000023
+70012,Modify the molecule Cc1ccc(NCCNc2ccc(C)cc2C)cc1 to increase its LogP value.,Cc1ccc(NCCNc2ccc(C)cc2C)cc1,4.135860000000003
+73200,Please optimize the molecule O=C1c2ccccc2C(=O)N1N1C(=O)c2ccc(Oc3cccc([N+](=O)[O-])c3)cc2C1=O to have a lower LogP value.,O=C1c2ccccc2C(=O)N1N1C(=O)c2ccc(Oc3cccc([N+](=O)[O-])c3)cc2C1=O,3.194300000000002
+14314,Optimize the molecule COc1ccccc1-n1ncc2c([O-])nc(-n3nc(C)cc3NC(=O)C3CCCC3)nc21 to have a lower LogP value.,COc1ccccc1-n1ncc2c([O-])nc(-n3nc(C)cc3NC(=O)C3CCCC3)nc21,2.5205200000000003
+91401,Modify the molecule Cc1ccc(C)c(OCCSCc2cc(=O)n3ccccc3n2)c1 to have a higher LogP value.,Cc1ccc(C)c(OCCSCc2cc(=O)n3ccccc3n2)c1,3.623540000000002
+39321,Please modify the molecule CCOC(=O)c1ccc(OS(=O)(=O)c2ccc3c(c2)OCCO3)cc1 to decrease its LogP value.,CCOC(=O)c1ccc(OS(=O)(=O)c2ccc3c(c2)OCCO3)cc1,2.4022000000000006
+119051,Please modify the molecule Cc1c(C)c(C)c(S(=O)(=O)N(Cc2ccc(C(N)=O)cc2)C2CC2)c(C)c1C to decrease its LogP value.,Cc1c(C)c(C)c(S(=O)(=O)N(Cc2ccc(C(N)=O)cc2)C2CC2)c(C)c1C,3.680900000000003
+27807,Please modify the molecule C[C@H]1C[C@H]1c1ccc(CN(C)C(=O)c2ccc(N3CCCC3=O)cc2)o1 to decrease its LogP value.,C[C@H]1C[C@H]1c1ccc(CN(C)C(=O)c2ccc(N3CCCC3=O)cc2)o1,3.802000000000003
+244205,Please modify the molecule CC[NH2+]Cc1ccc(OCC(=O)NC2CCCC2)cn1 to decrease its LogP value.,CC[NH2+]Cc1ccc(OCC(=O)NC2CCCC2)cn1,0.6025
+1292,Modify the molecule CCCCC(=O)N1CCN(c2nc3cccnc3s2)CC1 to have a lower LogP value.,CCCCC(=O)N1CCN(c2nc3cccnc3s2)CC1,2.530100000000001
+203179,Modify the molecule CCOC(=O)c1cccc(NC(=O)NC[C@@H](O)c2ccc(F)cc2)c1 to increase its LogP value.,CCOC(=O)c1cccc(NC(=O)NC[C@@H](O)c2ccc(F)cc2)c1,2.8575000000000017
+137980,Please modify the molecule Cc1nc(SCC(=O)c2cccc(Br)c2)oc1C to increase its LogP value.,Cc1nc(SCC(=O)c2cccc(Br)c2)oc1C,4.028940000000002
+28492,Please optimize the molecule CCCCC(=O)N(C)CC(=O)Nc1cc(Cl)ccc1OC to have a lower LogP value.,CCCCC(=O)N(C)CC(=O)Nc1cc(Cl)ccc1OC,2.9357000000000006
+235420,Please optimize the molecule CC(C)=CCC[C@@]1(C)CCC(=O)N(Cc2csc3[n+]2CCN3)C1 to have a lower LogP value.,CC(C)=CCC[C@@]1(C)CCC(=O)N(Cc2csc3[n+]2CCN3)C1,3.3362000000000016
+221047,Optimize the molecule CN(CC(C)(C)O)C(=O)Cc1ccc(C(F)(F)F)cc1 to have a higher LogP value.,CN(CC(C)(C)O)C(=O)Cc1ccc(C(F)(F)F)cc1,2.4772000000000007
+8015,Optimize the molecule O=C(Nc1ccccc1)[C@H]1CCCN(C(=O)[C@@H]2C=C(c3ccncc3)N=N2)C1 to have a lower LogP value.,O=C(Nc1ccccc1)[C@H]1CCCN(C(=O)[C@@H]2C=C(c3ccncc3)N=N2)C1,3.1342000000000017
+64479,Optimize the molecule COc1ccc2c(c1)N(S(=O)(=O)CC1CCC1)CCO2 to have a lower LogP value.,COc1ccc2c(c1)N(S(=O)(=O)CC1CCC1)CCO2,2.0239
+4123,Modify the molecule C=CCn1c(C)nn(C[NH+]2CCC[C@H](C(=O)NCCC)C2)c1=S to have a higher LogP value.,C=CCn1c(C)nn(C[NH+]2CCC[C@H](C(=O)NCCC)C2)c1=S,0.6871100000000008
+5752,Please optimize the molecule Cc1ccc(N2CC[NH2+][C@H](C)C2)c(C)n1 to have a lower LogP value.,Cc1ccc(N2CC[NH2+][C@H](C)C2)c(C)n1,0.47034
+29694,Please modify the molecule OCC#Cc1ccsc1CN1CC[NH+]2CCCC[C@@H]2C1 to decrease its LogP value.,OCC#Cc1ccsc1CN1CC[NH+]2CCCC[C@@H]2C1,0.34490000000000043
+58815,Modify the molecule CCOc1cc2c(cc1/C=C(\C#N)c1nc3ccccc3[nH]1)OCO2 to have a lower LogP value.,CCOc1cc2c(cc1/C=C(\C#N)c1nc3ccccc3[nH]1)OCO2,3.7544800000000036
+28318,Modify the molecule C[C@H](Cc1ccccc1F)C(=O)N[C@@H]1CCN(c2ccccc2F)C1=O to have a higher LogP value.,C[C@H](Cc1ccccc1F)C(=O)N[C@@H]1CCN(c2ccccc2F)C1=O,3.065100000000001
+167098,Modify the molecule C[C@@H](NC(=O)CCC1CCCCC1)c1ccc(S(N)(=O)=O)cc1 to have a lower LogP value.,C[C@@H](NC(=O)CCC1CCCCC1)c1ccc(S(N)(=O)=O)cc1,2.8717000000000006
+185242,Modify the molecule O=C(CNC(=O)c1ccc(-c2cscn2)cc1)Nc1ccc(F)cc1 to have a lower LogP value.,O=C(CNC(=O)c1ccc(-c2cscn2)cc1)Nc1ccc(F)cc1,3.317700000000001
+106099,Modify the molecule COc1ncncc1NC(=O)N[C@@H](CC(F)(F)F)c1ccc(F)cc1 to increase its LogP value.,COc1ncncc1NC(=O)N[C@@H](CC(F)(F)F)c1ccc(F)cc1,3.4395000000000016
+1408,Modify the molecule [NH3+]C[C@H]1CCC[C@H]1N1CCOCC1 to increase its LogP value.,[NH3+]C[C@H]1CCC[C@H]1N1CCOCC1,-0.27080000000000015
+165333,Please optimize the molecule N#Cc1ccc(C(=O)Nc2cccnc2Cl)cc1 to have a higher LogP value.,N#Cc1ccc(C(=O)Nc2cccnc2Cl)cc1,2.8589800000000007
+221571,Optimize the molecule O=C([O-])/C=C/C(=O)Nc1ccccn1 to have a higher LogP value.,O=C([O-])/C=C/C(=O)Nc1ccccn1,-0.6738000000000008
+195104,Modify the molecule Cc1c(NS(=O)(=O)c2cccc3c2C(=O)c2ccccc2C3=O)c(=O)n(-c2ccccc2)n1C to have a lower LogP value.,Cc1c(NS(=O)(=O)c2cccc3c2C(=O)c2ccccc2C3=O)c(=O)n(-c2ccccc2)n1C,3.060620000000001
+160886,Please modify the molecule Cc1cc(S(=O)(=O)N[C@H](C)CC(C)C)cc(N)c1C to decrease its LogP value.,Cc1cc(S(=O)(=O)N[C@H](C)CC(C)C)cc(N)c1C,2.5985400000000007
+167975,Optimize the molecule COc1ccc(NC(=O)Nc2nnc(CCc3ccccc3)s2)cc1 to have a higher LogP value.,COc1ccc(NC(=O)Nc2nnc(CCc3ccccc3)s2)cc1,3.975900000000002
+187637,Modify the molecule CC1(CNC(=O)Cc2ccc(S(=O)(=O)C(F)F)cc2)CCCC1 to have a lower LogP value.,CC1(CNC(=O)Cc2ccc(S(=O)(=O)C(F)F)cc2)CCCC1,2.9219000000000017
+149974,Please modify the molecule C/C(=N\NC(=O)c1cc(-c2ccc(F)cc2)[nH]n1)c1cccc2ccccc12 to increase its LogP value.,C/C(=N\NC(=O)c1cc(-c2ccc(F)cc2)[nH]n1)c1cccc2ccccc12,4.523000000000002
+241775,Modify the molecule O=C(COc1ccccc1)Nc1cccc(-c2cnc3ccccc3n2)c1 to have a higher LogP value.,O=C(COc1ccccc1)Nc1cccc(-c2cnc3ccccc3n2)c1,4.314300000000003
+180795,Modify the molecule CC(C)C[C@H]1C[NH2+]CCC12Cc1ccccc1C2 to increase its LogP value.,CC(C)C[C@H]1C[NH2+]CCC12Cc1ccccc1C2,2.4010000000000007
+111600,Modify the molecule Cc1nn(Cc2ccccc2)c(Cl)c1C(=O)N1CCC1 to have a higher LogP value.,Cc1nn(Cc2ccccc2)c(Cl)c1C(=O)N1CCC1,2.7391200000000016
+117881,Modify the molecule CC[C@H](CCO)C[NH2+][C@@H](C)c1cc(C)sc1C to decrease its LogP value.,CC[C@H](CCO)C[NH2+][C@@H](C)c1cc(C)sc1C,2.39794
+7576,Please optimize the molecule C[NH2+][C@@H](C)c1nc2ncc(C)cc2[n-]1 to have a lower LogP value.,C[NH2+][C@@H](C)c1nc2ncc(C)cc2[n-]1,0.14961999999999964
+97676,Please modify the molecule Cc1ccc(CC(=O)N2CCN(CC(=O)N(C)CCC#N)CC2)cc1 to increase its LogP value.,Cc1ccc(CC(=O)N2CCN(CC(=O)N(C)CCC#N)CC2)cc1,1.0538000000000005
+97245,Please optimize the molecule [O-]c1ncnc2c(Br)[nH]nc12 to have a higher LogP value.,[O-]c1ncnc2c(Br)[nH]nc12,0.189
+114532,Please modify the molecule O=C(CCCn1cncn1)N[C@H]1CCc2[nH+]ccn2C1 to increase its LogP value.,O=C(CCCn1cncn1)N[C@H]1CCc2[nH+]ccn2C1,-0.19489999999999963
+209955,Modify the molecule C[C@@H]1CCC[C@@H]([NH+]2CCC(N[C@@H](CO)c3cc(F)c(F)c(F)c3)CC2)C1 to have a higher LogP value.,C[C@@H]1CCC[C@@H]([NH+]2CCC(N[C@@H](CO)c3cc(F)c(F)c(F)c3)CC2)C1,2.3529
+234183,Modify the molecule O=C([C@@H]1CCCCN1C(=O)c1cccc2[nH]ccc12)N1CCOCC1 to have a higher LogP value.,O=C([C@@H]1CCCCN1C(=O)c1cccc2[nH]ccc12)N1CCOCC1,2.0214
+112582,Modify the molecule Cc1cc(NC(=O)C[C@@H]2Oc3ccccc3NC2=O)ccc1Br to have a lower LogP value.,Cc1cc(NC(=O)C[C@@H]2Oc3ccccc3NC2=O)ccc1Br,3.4858200000000013
+174868,Modify the molecule C[C@H](CC(=O)[O-])Sc1ccc(F)cc1 to have a lower LogP value.,C[C@H](CC(=O)[O-])Sc1ccc(F)cc1,1.4463000000000001
+71984,Modify the molecule O=C(Nc1nnc(-c2cc3ccccc3o2)o1)c1ccccc1Br to decrease its LogP value.,O=C(Nc1nnc(-c2cc3ccccc3o2)o1)c1ccccc1Br,4.497600000000001
+183179,Optimize the molecule CC[S@@](=O)[C@H]1CCCC[C@@H]1[NH2+]Cc1ccc(F)cc1F to have a higher LogP value.,CC[S@@](=O)[C@H]1CCCC[C@@H]1[NH2+]Cc1ccc(F)cc1F,2.1079999999999997
+156969,Modify the molecule O=C(c1nn(Cc2ccncc2)c2c1CN(C(=O)[C@@H](c1ccccc1)C1CCCC1)CC2)N1CCCC1 to decrease its LogP value.,O=C(c1nn(Cc2ccncc2)c2c1CN(C(=O)[C@@H](c1ccccc1)C1CCCC1)CC2)N1CCCC1,4.4211000000000045
+238542,Please optimize the molecule C=CCN(CC=C)C(=O)c1cccc([N+](=O)[O-])c1 to have a higher LogP value.,C=CCN(CC=C)C(=O)c1cccc([N+](=O)[O-])c1,2.4090000000000007
+50248,Modify the molecule O=[N+]([O-])c1ccc2nc(NC[C@H]3CCC[C@@H]3O)oc2c1 to have a lower LogP value.,O=[N+]([O-])c1ccc2nc(NC[C@H]3CCC[C@@H]3O)oc2c1,2.3089000000000004
+58399,Please optimize the molecule Cc1ccc2c(c1)=[NH+]C(=O)[C@H](CN(C(=O)C1CCCCC1)C(C)(C)C)C=2 to have a higher LogP value.,Cc1ccc2c(c1)=[NH+]C(=O)[C@H](CN(C(=O)C1CCCCC1)C(C)(C)C)C=2,0.8395200000000012
+112135,Modify the molecule Cc1ccccc1-n1c(SCC(N)=O)nnc1-c1ccccn1 to have a lower LogP value.,Cc1ccccc1-n1c(SCC(N)=O)nnc1-c1ccccn1,2.2151199999999998
+64632,Modify the molecule COc1cc(NC2CCN(S(=O)(=O)C3CC3)CC2)ccc1[N+](=O)[O-] to have a lower LogP value.,COc1cc(NC2CCN(S(=O)(=O)C3CC3)CC2)ccc1[N+](=O)[O-],1.9718999999999995
+240384,Modify the molecule CN(C)C(=O)c1cccc(C(=O)OC2CCN(CC(F)(F)F)CC2)c1 to have a lower LogP value.,CN(C)C(=O)c1cccc(C(=O)OC2CCN(CC(F)(F)F)CC2)c1,2.571900000000001
+68205,Please modify the molecule Cc1ccccc1[C@@H](Nc1cncc(C(N)=O)n1)C(C)(C)C to decrease its LogP value.,Cc1ccccc1[C@@H](Nc1cncc(C(N)=O)n1)C(C)(C)C,3.0832200000000016
+213140,Optimize the molecule Cc1noc(C)c1C[NH+]1CC[C@H](NC(=O)OC(C)(C)C)C1 to have a lower LogP value.,Cc1noc(C)c1C[NH+]1CC[C@H](NC(=O)OC(C)(C)C)C1,0.9733400000000001
+46252,Please modify the molecule Cc1ccc2oc(SCCCS(C)(=O)=O)nc2c1 to increase its LogP value.,Cc1ccc2oc(SCCCS(C)(=O)=O)nc2c1,2.6630200000000004
+199089,Please modify the molecule COC(=O)c1cc(Nc2cccnc2C)c(F)cc1N to decrease its LogP value.,COC(=O)c1cc(Nc2cccnc2C)c(F)cc1N,2.64152
+203010,Please optimize the molecule Cc1cc(C[C@@H](C)[NH2+]C2CCN(c3ccc(Cl)cc3)CC2)n[nH]1 to have a lower LogP value.,Cc1cc(C[C@@H](C)[NH2+]C2CCN(c3ccc(Cl)cc3)CC2)n[nH]1,2.5349199999999996
+189737,Modify the molecule C[S@@](=O)c1ccc(CNCC(C)(C)c2ccc(F)cc2)cc1 to have a higher LogP value.,C[S@@](=O)c1ccc(CNCC(C)(C)c2ccc(F)cc2)cc1,3.6305000000000023
+164671,Modify the molecule Cc1ncc([C@@H](C)N[C@@H]2CCN(c3ccccc3Cl)C2=O)c(C)n1 to increase its LogP value.,Cc1ncc([C@@H](C)N[C@@H]2CCN(c3ccccc3Cl)C2=O)c(C)n1,3.2029400000000017
+159284,Please optimize the molecule CC(C)[C@H](NC(=O)C=C1CCSCC1)c1nc(-c2ccncc2)no1 to have a higher LogP value.,CC(C)[C@H](NC(=O)C=C1CCSCC1)c1nc(-c2ccncc2)no1,3.3983000000000025
+68542,Optimize the molecule COC(=O)[C@@](C)(NCC(=O)N[C@@H]1CCCC[C@H]1C)C1CC1 to have a lower LogP value.,COC(=O)[C@@](C)(NCC(=O)N[C@@H]1CCCC[C@H]1C)C1CC1,1.6125999999999991
+178948,Please optimize the molecule Clc1cccc2c1OCC[C@@H]2NCc1cnc(-c2ccccn2)s1 to have a lower LogP value.,Clc1cccc2c1OCC[C@@H]2NCc1cnc(-c2ccccn2)s1,4.471900000000002
+92524,Optimize the molecule Cc1ccc(NC(=O)C2CCN(C(=O)Nc3ccc(C)c(C)c3)CC2)nc1 to have a higher LogP value.,Cc1ccc(NC(=O)C2CCN(C(=O)Nc3ccc(C)c(C)c3)CC2)nc1,3.8894600000000024
+186735,Modify the molecule C[C@@H](Oc1ccccc1C#N)C(=O)Oc1ccc(F)cc1 to have a lower LogP value.,C[C@@H](Oc1ccccc1C#N)C(=O)Oc1ccc(F)cc1,3.0702800000000012
+83805,Modify the molecule C[NH2+]C[C@H](C)C(=O)N(C)[C@H](C)c1cccc(Cl)c1 to have a lower LogP value.,C[NH2+]C[C@H](C)C(=O)N(C)[C@H](C)c1cccc(Cl)c1,1.6886999999999999
+178477,Modify the molecule N#C[C@H](OC(=O)COc1ccc(I)cc1)C1CC1 to increase its LogP value.,N#C[C@H](OC(=O)COc1ccc(I)cc1)C1CC1,2.5153800000000004
+230803,Modify the molecule CCOCCN(C)C(=O)Nc1ccc(-c2nnc(C)o2)cc1 to increase its LogP value.,CCOCCN(C)C(=O)Nc1ccc(-c2nnc(C)o2)cc1,2.5452200000000005
+191092,Modify the molecule CC#CCOc1ccc(S(=O)(=O)N2CCOCC2)cc1 to increase its LogP value.,CC#CCOc1ccc(S(=O)(=O)N2CCOCC2)cc1,1.1096
+49895,Please optimize the molecule Cc1cc(-c2cc(C(=O)N3CCCN(C(=O)OCC(C)C)CC3)c3cnn(C(C)C)c3n2)c(C)s1 to have a lower LogP value.,Cc1cc(-c2cc(C(=O)N3CCCN(C(=O)OCC(C)C)CC3)c3cnn(C(C)C)c3n2)c(C)s1,5.298040000000006
+88503,Modify the molecule C=CCn1c(Sc2nc(CC)ns2)nnc1-c1ccccc1C to have a higher LogP value.,C=CCn1c(Sc2nc(CC)ns2)nnc1-c1ccccc1C,4.004620000000003
+213459,Modify the molecule CCCOc1ccc2c(=O)c(-c3cc(C(=O)OC)oc3C)c(C)oc2c1 to have a higher LogP value.,CCCOc1ccc2c(=O)c(-c3cc(C(=O)OC)oc3C)c(C)oc2c1,4.2452400000000035
+51404,Please modify the molecule C[C@@H](OC(=O)c1csc(-c2cccs2)n1)[C@H]1CCOC1 to decrease its LogP value.,C[C@@H](OC(=O)c1csc(-c2cccs2)n1)[C@H]1CCOC1,3.453400000000002
+195841,Please optimize the molecule CC(C)CNC(=O)C(=O)Nc1cccnc1Br to have a higher LogP value.,CC(C)CNC(=O)C(=O)Nc1cccnc1Br,1.5547999999999995
+90396,Please modify the molecule CSc1ccsc1C(=O)NC[C@H](O)c1c(Cl)cccc1Cl to decrease its LogP value.,CSc1ccsc1C(=O)NC[C@H](O)c1c(Cl)cccc1Cl,4.240200000000002
+122,Please modify the molecule Cc1ccc2ncc(C(=O)Nc3ncccc3OCc3ccncc3)n2c1 to increase its LogP value.,Cc1ccc2ncc(C(=O)Nc3ncccc3OCc3ccncc3)n2c1,3.2640200000000013
+215535,Optimize the molecule CC(C)[C@H](C)NC(=O)CS(=O)(=O)Cc1cccc(C(N)=O)c1 to have a higher LogP value.,CC(C)[C@H](C)NC(=O)CS(=O)(=O)Cc1cccc(C(N)=O)c1,0.861
+29635,Please optimize the molecule Cc1cc(NCCCc2c(C)noc2C)nc(C)[nH+]1 to have a higher LogP value.,Cc1cc(NCCCc2c(C)noc2C)nc(C)[nH+]1,2.16208
+85173,Please modify the molecule O=c1c2ccc3c(=O)n(-c4nccs4)c(=O)c4ccc(c(=O)n1-c1nccs1)c2c34 to increase its LogP value.,O=c1c2ccc3c(=O)n(-c4nccs4)c(=O)c4ccc(c(=O)n1-c1nccs1)c2c34,3.354000000000002
+78212,Modify the molecule COC(=O)c1occc1CSc1ccc(Cl)cc1N to have a lower LogP value.,COC(=O)c1occc1CSc1ccc(Cl)cc1N,3.594100000000002
+238913,Optimize the molecule O=C(CCc1ccc(Cl)s1)Nc1cnn(CC[NH+]2CCCCC2)c1 to have a lower LogP value.,O=C(CCc1ccc(Cl)s1)Nc1cnn(CC[NH+]2CCCCC2)c1,2.2380999999999993
+64708,Please modify the molecule CCO[C@H]1C[C@H]1C(=O)Nc1ccccc1-n1ncc2c(=O)[nH]cnc21 to increase its LogP value.,CCO[C@H]1C[C@H]1C(=O)Nc1ccccc1-n1ncc2c(=O)[nH]cnc21,1.4722999999999997
+166324,Optimize the molecule CCOC(=O)c1c(C)c(C)cc(C)c1C to have a lower LogP value.,CCOC(=O)c1c(C)c(C)cc(C)c1C,3.096980000000002
+51923,Modify the molecule C#CCCOc1ccc(CN2CCC[C@@H](CN3CCOCC3)C2)cc1 to have a lower LogP value.,C#CCCOc1ccc(CN2CCC[C@@H](CN3CCOCC3)C2)cc1,2.632900000000001
+245615,Modify the molecule CCN(C(=O)NC1CC[NH+](C2CC2)CC1)C1CCCC1 to decrease its LogP value.,CCN(C(=O)NC1CC[NH+](C2CC2)CC1)C1CCCC1,1.1702000000000006
+107354,Optimize the molecule O=C(CCc1ccccc1Cl)NNC(=O)Cc1cccc2ccccc12 to have a higher LogP value.,O=C(CCc1ccccc1Cl)NNC(=O)Cc1cccc2ccccc12,3.815900000000002
+4893,Optimize the molecule O=C(Cc1ccc(N(Cc2ccccc2)C(=O)/C=C/c2ccccc2)cc1)N1CCOCC1 to have a lower LogP value.,O=C(Cc1ccc(N(Cc2ccccc2)C(=O)/C=C/c2ccccc2)cc1)N1CCOCC1,4.334500000000004
+195282,Modify the molecule CC(C)c1cc(NC(=O)CN(C)CC(C)(C)C[NH3+])on1 to have a lower LogP value.,CC(C)c1cc(NC(=O)CN(C)CC(C)(C)C[NH3+])on1,0.9364000000000006
+126994,Please modify the molecule Cc1cccc(C2(NC(=O)[C@H]3CCO[C@@H]3C)CCCC2)c1 to increase its LogP value.,Cc1cccc(C2(NC(=O)[C@H]3CCO[C@@H]3C)CCCC2)c1,3.3055200000000022
+30253,Optimize the molecule COC(OCC[NH+]1CCCCC1)(c1ccccc1)c1ccccc1 to have a lower LogP value.,COC(OCC[NH+]1CCCCC1)(c1ccccc1)c1ccccc1,2.6195000000000004
+18828,Please optimize the molecule Fc1cccc(-c2nnco2)c1 to have a higher LogP value.,Fc1cccc(-c2nnco2)c1,1.8756999999999997
+191117,Modify the molecule COc1ccccc1N1C[C@@H](C(=O)Nc2ccc(N3CCCCC3)c(Cl)c2)CC1=O to decrease its LogP value.,COc1ccccc1N1C[C@@H](C(=O)Nc2ccc(N3CCCCC3)c(Cl)c2)CC1=O,4.330500000000003
+97769,Please modify the molecule Cc1nn(-c2cccc(Br)c2)c(C)c1[C@@H]1C=C[C@@H]([NH2+]Cc2cccc(C#N)c2)C1 to decrease its LogP value.,Cc1nn(-c2cccc(Br)c2)c(C)c1[C@@H]1C=C[C@@H]([NH2+]Cc2cccc(C#N)c2)C1,4.299020000000003
+17139,Please optimize the molecule Cc1c(C(=O)N2CCCC2)sc2nc(-c3cccc([N+](=O)[O-])c3)cn12 to have a higher LogP value.,Cc1c(C(=O)N2CCCC2)sc2nc(-c3cccc([N+](=O)[O-])c3)cn12,3.5154200000000024
+85726,Please modify the molecule CC(C)NC(=O)CSc1ccccc1C(=O)N[C@H]1CCCC[C@@H]1C to decrease its LogP value.,CC(C)NC(=O)CSc1ccccc1C(=O)N[C@H]1CCCC[C@@H]1C,3.6118000000000023
+76153,Modify the molecule CCOC(=O)c1cc(C#N)c([O-])nc1C(F)(F)F to have a lower LogP value.,CCOC(=O)c1cc(C#N)c([O-])nc1C(F)(F)F,1.22238
+62979,Modify the molecule Cc1ccc(Cl)cc1NC(=O)CN1CCN(C2=[NH+]C[C@@H](C)S2)CC1 to increase its LogP value.,Cc1ccc(Cl)cc1NC(=O)CN1CCN(C2=[NH+]C[C@@H](C)S2)CC1,0.7764199999999999
+183178,Please optimize the molecule COc1ccc2c(c1)[C@H]([NH2+][C@H](C)CCN1CCOCC1)CCCO2 to have a higher LogP value.,COc1ccc2c(c1)[C@H]([NH2+][C@H](C)CCN1CCOCC1)CCCO2,1.5831000000000004
+232235,Please optimize the molecule CN(C(=O)CC(c1ccccc1)c1ccccc1)C1(C#N)CCC1 to have a higher LogP value.,CN(C(=O)CC(c1ccccc1)c1ccccc1)C1(C#N)CCC1,4.113280000000003
+97688,Modify the molecule C=CCNC(=O)c1ccc(COc2ccc(F)cc2)o1 to have a lower LogP value.,C=CCNC(=O)c1ccc(COc2ccc(F)cc2)o1,2.9135000000000018
+95208,Modify the molecule O=C(CSc1nnc(Cc2ccccc2)o1)c1cc([N+](=O)[O-])ccc1Cl to have a higher LogP value.,O=C(CSc1nnc(Cc2ccccc2)o1)c1cc([N+](=O)[O-])ccc1Cl,4.197000000000003
+197614,Modify the molecule O=C(Nc1ccnn1C1CCCCC1)c1cccc(Cl)c1 to have a lower LogP value.,O=C(Nc1ccnn1C1CCCCC1)c1cccc(Cl)c1,4.294000000000003
+66891,Optimize the molecule Cc1cc(Br)ccc1NC(=O)CN(C)S(=O)(=O)c1cccc(C#N)c1 to have a higher LogP value.,Cc1cc(Br)ccc1NC(=O)CN(C)S(=O)(=O)c1cccc(C#N)c1,2.8884000000000007
+209475,Modify the molecule CCC[NH+](C)C[C@H]1CCN(C(=O)c2ccc(Cl)c(Cl)c2)C1 to decrease its LogP value.,CCC[NH+](C)C[C@H]1CCN(C(=O)c2ccc(Cl)c(Cl)c2)C1,2.3802000000000003
+4245,Optimize the molecule O=C(CSCc1ccccc1)N(Cc1ccsc1)C1CC1 to have a higher LogP value.,O=C(CSCc1ccccc1)N(Cc1ccsc1)C1CC1,4.172500000000003
+105792,Please optimize the molecule CCc1nn(C)c(OC)c1CNC(=O)N1CC[C@H](CC)C1 to have a lower LogP value.,CCc1nn(C)c(OC)c1CNC(=O)N1CC[C@H](CC)C1,1.9325999999999997
+91905,Modify the molecule O=C(NCCc1ccco1)c1ccc(NC2=N[C@H]3CS(=O)(=O)C[C@H]3S2)cc1 to have a higher LogP value.,O=C(NCCc1ccco1)c1ccc(NC2=N[C@H]3CS(=O)(=O)C[C@H]3S2)cc1,1.9323999999999997
+570,Modify the molecule CCc1noc(CN(CC)C(=O)C(C)(C)NC(=O)c2cccs2)n1 to have a higher LogP value.,CCc1noc(CN(CC)C(=O)C(C)(C)NC(=O)c2cccs2)n1,2.2506000000000004
+19657,Modify the molecule Cc1ccc(NS(=O)(=O)c2ccccc2[N+](=O)[O-])cc1N1CCCC1=O to have a higher LogP value.,Cc1ccc(NS(=O)(=O)c2ccccc2[N+](=O)[O-])cc1N1CCCC1=O,2.830820000000001
+126711,Modify the molecule O=C(N[C@@H](c1ccc(Cl)cc1)c1ncon1)N(CC1CC1)CC1CC1 to decrease its LogP value.,O=C(N[C@@H](c1ccc(Cl)cc1)c1ncon1)N(CC1CC1)CC1CC1,3.644000000000002
+82894,Optimize the molecule Cc1ccc(C[C@@H]([NH3+])CC23CC4CC(CC(C4)C2)C3)cc1 to have a higher LogP value.,Cc1ccc(C[C@@H]([NH3+])CC23CC4CC(CC(C4)C2)C3)cc1,3.754520000000003
+197422,Please modify the molecule CC(C)(C)C(=O)NCC(=O)Nc1cc(Cl)ccc1C(=O)[O-] to decrease its LogP value.,CC(C)(C)C(=O)NCC(=O)Nc1cc(Cl)ccc1C(=O)[O-],0.8042999999999997
+196509,Please modify the molecule COc1ccc([C@@H](C)COC(=O)c2csc(-c3ncccn3)n2)cc1 to increase its LogP value.,COc1ccc([C@@H](C)COC(=O)c2csc(-c3ncccn3)n2)cc1,3.569200000000002
+59011,Modify the molecule CCCc1ccc(OC(=O)C2C[C@H](C)O[C@@H](C)C2)cc1 to decrease its LogP value.,CCCc1ccc(OC(=O)C2C[C@H](C)O[C@@H](C)C2)cc1,3.7481000000000027
+199886,Modify the molecule Cc1ccccc1Oc1nc2ccccn2c(=O)c1[N+](=O)[O-] to increase its LogP value.,Cc1ccccc1Oc1nc2ccccn2c(=O)c1[N+](=O)[O-],2.7034200000000004
+237156,Please modify the molecule CCOc1ccc2oc(C(=O)N3CCC(C(=O)OC)CC3)c(C)c2c1 to increase its LogP value.,CCOc1ccc2oc(C(=O)N3CCC(C(=O)OC)CC3)c(C)c2c1,3.1651200000000017
+55342,Modify the molecule CN(Cc1ccc(Cl)s1)C(=O)CN1C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O to have a lower LogP value.,CN(Cc1ccc(Cl)s1)C(=O)CN1C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O,3.0043000000000015
+233759,Modify the molecule CCC[NH+](C1CC1)[C@@H]1CCC[C@](NC2CC2)(C(N)=O)C1 to increase its LogP value.,CCC[NH+](C1CC1)[C@@H]1CCC[C@](NC2CC2)(C(N)=O)C1,0.3624000000000015
+98219,Please optimize the molecule C[C@@H]1CC(=O)C2=C(CC[C@@]3(O)[C@@H](O)c4c(O)cccc4C(=O)[C@H]23)C1 to have a lower LogP value.,C[C@@H]1CC(=O)C2=C(CC[C@@]3(O)[C@@H](O)c4c(O)cccc4C(=O)[C@H]23)C1,2.0586
+218375,Optimize the molecule C=CCNC(=O)c1cnn(-c2ncc3c(n2)-c2ccccc2CCC3)c1C1CC1 to have a lower LogP value.,C=CCNC(=O)c1cnn(-c2ncc3c(n2)-c2ccccc2CCC3)c1C1CC1,3.611200000000002
+65377,Optimize the molecule COc1ccc([C@@H]2C(C(=O)c3ccc(C)o3)=C([O-])C(=O)N2c2nc3c(C)cc(C)cc3s2)cc1 to have a lower LogP value.,COc1ccc([C@@H]2C(C(=O)c3ccc(C)o3)=C([O-])C(=O)N2c2nc3c(C)cc(C)cc3s2)cc1,4.408360000000004
+94167,Please modify the molecule Cn1nc(C(=O)N2C[C@@H](O)C[C@H]2C(=O)[O-])ccc1=O to decrease its LogP value.,Cn1nc(C(=O)N2C[C@@H](O)C[C@H]2C(=O)[O-])ccc1=O,-2.8943999999999983
+151281,Please optimize the molecule Cn1c(C2CC2)nc2cc(NC(=O)C(=O)N3CCC[C@@](C)(CO)C3)ccc21 to have a higher LogP value.,Cn1c(C2CC2)nc2cc(NC(=O)C(=O)N3CCC[C@@](C)(CO)C3)ccc21,2.0101999999999993
+163338,Modify the molecule Cc1ccc(C[NH2+]C2CCN(C3CC3)CC2)cc1C to increase its LogP value.,Cc1ccc(C[NH2+]C2CCN(C3CC3)CC2)cc1C,1.9936399999999996
+50811,Modify the molecule CC(=O)N1CCC[C@@H](C(=O)NCCC[NH+]2CCN(c3cccc(C)c3)CC2)C1 to have a higher LogP value.,CC(=O)N1CCC[C@@H](C(=O)NCCC[NH+]2CCN(c3cccc(C)c3)CC2)C1,0.4647200000000036
+181594,Optimize the molecule CCOC(=O)c1[nH]ncc1CN1CCO[C@@H](c2cccc(O)c2)C1 to have a higher LogP value.,CCOC(=O)c1[nH]ncc1CN1CCO[C@@H](c2cccc(O)c2)C1,1.8655000000000002
+62596,Optimize the molecule CC[C@H](C)NC(=O)c1cccc(CNC(=O)C(=O)Nc2ccc(F)cc2)c1 to have a lower LogP value.,CC[C@H](C)NC(=O)c1cccc(CNC(=O)C(=O)Nc2ccc(F)cc2)c1,2.6089
+63880,Please optimize the molecule Cc1nc(N2CCn3c(nn(C)c3=O)C2)c2c(CC(C)C)csc2n1 to have a higher LogP value.,Cc1nc(N2CCn3c(nn(C)c3=O)C2)c2c(CC(C)C)csc2n1,2.11362
+217866,Optimize the molecule NC(=O)c1cc(NC(=O)Cc2ccc(Cl)c(Cl)c2)c(F)cc1F to have a lower LogP value.,NC(=O)c1cc(NC(=O)Cc2ccc(Cl)c(Cl)c2)c(F)cc1F,3.551700000000001
+162054,Modify the molecule C[C@@H]1SCCN(C(=O)[C@@H]2CCC(=O)O2)[C@H]1c1ccccc1 to decrease its LogP value.,C[C@@H]1SCCN(C(=O)[C@@H]2CCC(=O)O2)[C@H]1c1ccccc1,2.3972000000000007
+106465,Optimize the molecule O=C(Nc1ccccn1)c1cc2ccc(O)cc2o/c1=[NH+]\c1cccc(F)c1 to have a higher LogP value.,O=C(Nc1ccccn1)c1cc2ccc(O)cc2o/c1=[NH+]\c1cccc(F)c1,2.2378
+130525,Please optimize the molecule CC(=O)c1ccc(NC(=O)c2cc3occc3n2C)cc1 to have a higher LogP value.,CC(=O)c1ccc(NC(=O)c2cc3occc3n2C)cc1,3.2262000000000013
+58432,Optimize the molecule CCOc1ccc(N(Cc2nc3nc(C)cc([O-])n3n2)C(=O)c2cccc(C)c2)cc1 to have a lower LogP value.,CCOc1ccc(N(Cc2nc3nc(C)cc([O-])n3n2)C(=O)c2cccc(C)c2)cc1,3.0604400000000016
+133171,Please optimize the molecule CCCCNC(=O)NC[C@H](OC)c1ccc(F)cc1 to have a higher LogP value.,CCCCNC(=O)NC[C@H](OC)c1ccc(F)cc1,2.6125000000000007
+92962,Please optimize the molecule O=C(CN1CCCOC1=O)NCc1cccnc1 to have a lower LogP value.,O=C(CN1CCCOC1=O)NCc1cccnc1,0.5400999999999998
+15046,Please optimize the molecule [NH3+][C@@H](c1ccc(F)c(F)c1F)c1csc2ccccc12 to have a lower LogP value.,[NH3+][C@@H](c1ccc(F)c(F)c1F)c1csc2ccccc12,3.6499000000000006
+111315,Optimize the molecule C[C@@H]1CN(C2CCN(c3c(C#N)cnc4ccc(Cl)cc34)CC2)CCO1 to have a higher LogP value.,C[C@@H]1CN(C2CCN(c3c(C#N)cnc4ccc(Cl)cc34)CC2)CCO1,3.4493800000000023
+171310,Modify the molecule O=C(Cc1ccc(Cl)c(Cl)c1)N1CCC(CN2CCOCC2)CC1 to have a lower LogP value.,O=C(Cc1ccc(Cl)c(Cl)c1)N1CCC(CN2CCOCC2)CC1,3.106700000000002
+78531,Please modify the molecule Cc1csc(N(C(=O)c2cccc(NC(=O)CCn3cc[nH+]c3)c2)c2ccccc2)n1 to decrease its LogP value.,Cc1csc(N(C(=O)c2cccc(NC(=O)CCn3cc[nH+]c3)c2)c2ccccc2)n1,4.074420000000002
+151298,Optimize the molecule COC(=O)[C@H](C)Sc1nnc(N2CCC[C@@H](C)C2)n1Cc1ccco1 to have a lower LogP value.,COC(=O)[C@H](C)Sc1nnc(N2CCC[C@@H](C)C2)n1Cc1ccco1,2.8093000000000012
+148928,Modify the molecule CNC(=O)[C@@H](C)NC(=O)c1cccc(C(F)(F)F)c1F to have a higher LogP value.,CNC(=O)[C@@H](C)NC(=O)c1cccc(C(F)(F)F)c1F,1.7087999999999997
+206776,Optimize the molecule CCc1nn(C)cc1NC(=O)N(CCO)C1CC1 to have a lower LogP value.,CCc1nn(C)cc1NC(=O)N(CCO)C1CC1,0.9710999999999999
+230827,Optimize the molecule CC1=C(/C=C/C(C)=N/NC(N)=[NH2+])C(C)(C)CCC1 to have a higher LogP value.,CC1=C(/C=C/C(C)=N/NC(N)=[NH2+])C(C)(C)CCC1,1.1085
+214957,Modify the molecule Cc1csc(N(C(=O)CN2C(=O)N[C@@]3(CCc4ccccc43)C2=O)c2ccccc2)n1 to decrease its LogP value.,Cc1csc(N(C(=O)CN2C(=O)N[C@@]3(CCc4ccccc43)C2=O)c2ccccc2)n1,3.5097200000000024
+232839,Optimize the molecule COc1ccccc1CNC(=O)[C@H]1CCCN(C(=O)c2cnn(-c3ccccc3)c2-n2cccc2)C1 to have a lower LogP value.,COc1ccccc1CNC(=O)[C@H]1CCCN(C(=O)c2cnn(-c3ccccc3)c2-n2cccc2)C1,3.840200000000003
+42491,Modify the molecule Cc1cc(N2CCO[C@@H](c3ccc(F)c(F)c3)C2)ncc1[N+](=O)[O-] to have a higher LogP value.,Cc1cc(N2CCO[C@@H](c3ccc(F)c(F)c3)C2)ncc1[N+](=O)[O-],3.154320000000002
+193677,Modify the molecule COc1ccc(C[NH+]2CCNC(=O)[C@@H]2CC(N)=O)cc1C to increase its LogP value.,COc1ccc(C[NH+]2CCNC(=O)[C@@H]2CC(N)=O)cc1C,-1.2376799999999966
+93812,Modify the molecule COc1ccc([C@H]2CC(=O)NC3=C2C(=O)C[C@@H](c2ccc(OC(C)C)c(OC)c2)C3)cc1Cl to increase its LogP value.,COc1ccc([C@H]2CC(=O)NC3=C2C(=O)C[C@@H](c2ccc(OC(C)C)c(OC)c2)C3)cc1Cl,5.148700000000005
+68255,Modify the molecule Cc1cc(N2CCCCC2)nc(NCCNC(=O)Nc2ccc(C)c(Cl)c2)n1 to increase its LogP value.,Cc1cc(N2CCCCC2)nc(NCCNC(=O)Nc2ccc(C)c(Cl)c2)n1,3.970740000000002
+117154,Modify the molecule CCO[C@@H](C)c1noc(CN(C)Cc2c(F)cccc2Cl)n1 to increase its LogP value.,CCO[C@@H](C)c1noc(CN(C)Cc2c(F)cccc2Cl)n1,3.5916000000000023
+57209,Optimize the molecule O=C([O-])[C@@H](Cc1cccc(F)c1)[C@H]1CCCCC[C@@H]1O to have a higher LogP value.,O=C([O-])[C@@H](Cc1cccc(F)c1)[C@H]1CCCCC[C@@H]1O,1.6754999999999993
+213615,Modify the molecule COc1ccc(-c2c(=O)n(OC)c3ccccc3[n+]2[O-])cc1 to increase its LogP value.,COc1ccc(-c2c(=O)n(OC)c3ccccc3[n+]2[O-])cc1,1.3689
+202335,Please optimize the molecule Cc1ccc2c(c1)N(C)C(=O)[C@](C)(C(=O)Nc1cccc(C)n1)O2 to have a lower LogP value.,Cc1ccc2c(c1)N(C)C(=O)[C@](C)(C(=O)Nc1cccc(C)n1)O2,2.45104
+72418,Please optimize the molecule CCn1nc(C)c(CNC(=O)C2CCN(C(=O)/C=C/c3ccccc3)CC2)c1C to have a lower LogP value.,CCn1nc(C)c(CNC(=O)C2CCN(C(=O)/C=C/c3ccccc3)CC2)c1C,3.0880400000000012
+118076,Please modify the molecule COc1ccccc1-c1cc(C(=O)Nc2ccc(C)cn2)no1 to increase its LogP value.,COc1ccccc1-c1cc(C(=O)Nc2ccc(C)cn2)no1,3.3059200000000004
+84161,Please modify the molecule CC(C)c1c(C(=O)NCCO)nnn1Cc1ccccc1 to decrease its LogP value.,CC(C)c1c(C(=O)NCCO)nnn1Cc1ccccc1,1.1718999999999995
+40278,Please optimize the molecule Cc1cc(C)cc(N(CC(=O)NCC(C)C)S(C)(=O)=O)c1 to have a higher LogP value.,Cc1cc(C)cc(N(CC(=O)NCC(C)C)S(C)(=O)=O)c1,1.84164
+115430,Please optimize the molecule Fc1cccc(F)c1N[C@@H]1CCOC2(CCCC2)C1 to have a lower LogP value.,Fc1cccc(F)c1N[C@@H]1CCOC2(CCCC2)C1,3.8685000000000027
+227036,Please optimize the molecule COc1ccc(CN2C(=O)[C@@H]([NH3+])[C@H]2[C@H]2COC(C)(C)O2)cc1OC to have a higher LogP value.,COc1ccc(CN2C(=O)[C@@H]([NH3+])[C@H]2[C@H]2COC(C)(C)O2)cc1OC,0.17660000000000187
+69065,Please modify the molecule Cc1cc2cc(/C(N)=N/O)c(=O)[nH]c2cc1C to increase its LogP value.,Cc1cc2cc(/C(N)=N/O)c(=O)[nH]c2cc1C,1.2394399999999999
+177497,Please modify the molecule O=S(=O)(c1ccc(Br)cc1)N1CCN(C2CC2)C[C@@H]1c1ccccc1 to decrease its LogP value.,O=S(=O)(c1ccc(Br)cc1)N1CCN(C2CC2)C[C@@H]1c1ccccc1,3.659100000000003
+224493,Please optimize the molecule CC(C)[C@H]1CCC[NH+]([C@@H](C)[C@@H](C)C[NH3+])CC1 to have a lower LogP value.,CC(C)[C@H]1CCC[NH+]([C@@H](C)[C@@H](C)C[NH3+])CC1,0.5939000000000028
+105104,Please optimize the molecule O=C(CN1C(=O)S/C(=C\c2cccn2-c2ccc(O)cc2)C1=O)N1CCN(c2ccccc2)CC1 to have a lower LogP value.,O=C(CN1C(=O)S/C(=C\c2cccn2-c2ccc(O)cc2)C1=O)N1CCN(c2ccccc2)CC1,3.5680000000000023
+93217,Please modify the molecule O=Cc1ccc(OCCC(=O)Nc2cccnc2-n2cccn2)cc1 to decrease its LogP value.,O=Cc1ccc(OCCC(=O)Nc2cccnc2-n2cccn2)cc1,2.4874
+53180,Please modify the molecule COCc1cccc(CNC(=O)Cn2ccc(=O)[nH]c2=O)c1 to decrease its LogP value.,COCc1cccc(CNC(=O)Cn2ccc(=O)[nH]c2=O)c1,-0.0005999999999996564
+33205,Please optimize the molecule CN(Cc1cn(-c2ccccc2)nc1-c1cccs1)C(=O)Cc1ccc(N2CCCC2=O)cc1 to have a higher LogP value.,CN(Cc1cn(-c2ccccc2)nc1-c1cccs1)C(=O)Cc1ccc(N2CCCC2=O)cc1,4.9287000000000045
+200536,Modify the molecule Cc1ccc(C(=O)N2CCN(C(=O)C3(c4cccc(Cl)c4)CC3)CC2)s1 to have a lower LogP value.,Cc1ccc(C(=O)N2CCN(C(=O)C3(c4cccc(Cl)c4)CC3)CC2)s1,3.7261200000000034
+52132,Optimize the molecule C[C@H]1c2[nH]c3ccccc3c2CCN1C(=O)NCCS(=O)(=O)c1ccccc1 to have a lower LogP value.,C[C@H]1c2[nH]c3ccccc3c2CCN1C(=O)NCCS(=O)(=O)c1ccccc1,3.270500000000002
+68606,Modify the molecule O=C(Cc1cccnc1)NCc1cc2n(n1)CC[NH+](C1CCCCC1)C2 to decrease its LogP value.,O=C(Cc1cccnc1)NCc1cc2n(n1)CC[NH+](C1CCCCC1)C2,0.8681999999999999
+50522,Modify the molecule CC1CC[NH+]([C@@H](CNC(=O)Nc2ccc([C@H](C)N3CCOCC3)cc2)C(C)C)CC1 to increase its LogP value.,CC1CC[NH+]([C@@H](CNC(=O)Nc2ccc([C@H](C)N3CCOCC3)cc2)C(C)C)CC1,2.540700000000001
+26335,Please modify the molecule O=C1C[C@@H](c2ccccc2[N+](=O)[O-])c2ccc3ccccc3c2N1 to increase its LogP value.,O=C1C[C@@H](c2ccccc2[N+](=O)[O-])c2ccc3ccccc3c2N1,4.222100000000002
+7152,Modify the molecule COc1ncccc1-c1cc(C)ccc1N1CCOC1=O to have a higher LogP value.,COc1ncccc1-c1cc(C)ccc1N1CCOC1=O,3.0222200000000017
+185866,Modify the molecule COCC[S@](=O)[C@H](C)C(=O)Nc1ccc(C)c(Cl)c1 to have a lower LogP value.,COCC[S@](=O)[C@H](C)C(=O)Nc1ccc(C)c(Cl)c1,2.37052
+88141,Optimize the molecule Cc1c(N2CCCC[C@@H]2c2cn[nH]c2)cc(C#N)cc1[N+](=O)[O-] to have a lower LogP value.,Cc1c(N2CCCC[C@@H]2c2cn[nH]c2)cc(C#N)cc1[N+](=O)[O-],3.2296000000000014
+41729,Modify the molecule COc1ccc(C(=O)Cn2nc(-c3ccc(SC)cc3)ccc2=O)cc1OC to decrease its LogP value.,COc1ccc(C(=O)Cn2nc(-c3ccc(SC)cc3)ccc2=O)cc1OC,3.532300000000002
+104528,Please optimize the molecule COc1ccc([C@@H]2CCCN2C(=O)CCCn2cnc3c2c(=O)n(C)c(=O)n3C)cc1 to have a lower LogP value.,COc1ccc([C@@H]2CCCN2C(=O)CCCn2cnc3c2c(=O)n(C)c(=O)n3C)cc1,1.5861999999999996
+47679,Modify the molecule C[C@H](C(=O)Nc1ccc(C#N)cc1)[NH+](C)CC(=O)Nc1cccc2ccccc12 to have a lower LogP value.,C[C@H](C(=O)Nc1ccc(C#N)cc1)[NH+](C)CC(=O)Nc1cccc2ccccc12,2.1918800000000003
+77650,Modify the molecule CSCc1ccc(C(=O)N[C@@H](Cc2c[nH+]c[nH]2)C(=O)[O-])o1 to have a lower LogP value.,CSCc1ccc(C(=O)N[C@@H](Cc2c[nH+]c[nH]2)C(=O)[O-])o1,-0.6241999999999988
+140022,Optimize the molecule NC(=O)CN1C(=O)[C@]2(CCN(C(=O)c3cn[nH]n3)C2)c2ccccc21 to have a higher LogP value.,NC(=O)CN1C(=O)[C@]2(CCN(C(=O)c3cn[nH]n3)C2)c2ccccc21,-0.5794999999999981
+96143,Please modify the molecule CC(C)(C)c1ccc(/C=C/C(=O)N2CC(=O)Nc3ccccc32)cc1 to increase its LogP value.,CC(C)(C)c1ccc(/C=C/C(=O)N2CC(=O)Nc3ccccc32)cc1,3.9826000000000032
+101116,Modify the molecule COc1cccc(C(=O)NCC(=O)Nc2ccon2)c1 to have a higher LogP value.,COc1cccc(C(=O)NCC(=O)Nc2ccon2)c1,1.0516999999999996
+120517,Please modify the molecule CCOc1ccc(-c2ccc(=O)n(CC(=O)Nc3cc(C(F)(F)F)ccc3Cl)n2)cc1 to increase its LogP value.,CCOc1ccc(-c2ccc(=O)n(CC(=O)Nc3cc(C(F)(F)F)ccc3Cl)n2)cc1,4.619900000000003
+97191,Please optimize the molecule C[NH+]1CCN(c2nc(C(=O)NC3CCCC3)cs2)CC1 to have a higher LogP value.,C[NH+]1CCN(c2nc(C(=O)NC3CCCC3)cs2)CC1,0.15020000000000078
+157468,Modify the molecule Nc1ccccc1C(=O)CCN1C(=O)c2ccccc2C1=O to increase its LogP value.,Nc1ccccc1C(=O)CCN1C(=O)c2ccccc2C1=O,2.1378000000000004
+185451,Optimize the molecule CC[NH+]1CCOC(=O)[C@H]1CC(=O)Nc1ccc2c(c1)OCCO2 to have a lower LogP value.,CC[NH+]1CCOC(=O)[C@H]1CC(=O)Nc1ccc2c(c1)OCCO2,-0.3833999999999991
+176578,Please optimize the molecule COc1ccc(Cl)c2sc(N(Cc3ccncc3)C(=O)[C@H]3CCCN3S(C)(=O)=O)nc12 to have a higher LogP value.,COc1ccc(Cl)c2sc(N(Cc3ccncc3)C(=O)[C@H]3CCCN3S(C)(=O)=O)nc12,3.310500000000002
+231751,Optimize the molecule Cc1cnc(CCN(C)C(=O)N[C@@H]2CCCC[C@@H]2OC2CCCC2)s1 to have a higher LogP value.,Cc1cnc(CCN(C)C(=O)N[C@@H]2CCCC[C@@H]2OC2CCCC2)s1,3.905820000000003
+37033,Please optimize the molecule CN(Cc1[nH]c(-c2ccccc2)c[nH+]1)[C@@H]1CCCC[C@@H]1O to have a higher LogP value.,CN(Cc1[nH]c(-c2ccccc2)c[nH+]1)[C@@H]1CCCC[C@@H]1O,2.231100000000001
+219581,Please modify the molecule Fc1cccc([C@@H]2N[C@H](c3nccs3)Cc3ccsc32)c1F to decrease its LogP value.,Fc1cccc([C@@H]2N[C@H](c3nccs3)Cc3ccsc32)c1F,4.459200000000002
+110056,Optimize the molecule Cc1ccc(C)c(CC(=O)Nc2nnc(Cc3ccc(C)c(C)c3)o2)c1 to have a lower LogP value.,Cc1ccc(C)c(CC(=O)Nc2nnc(Cc3ccc(C)c(C)c3)o2)c1,4.075280000000003
+60619,Modify the molecule COc1ccc(SCc2nc3ccc(Cl)cc3c(=O)[nH]2)cc1 to increase its LogP value.,COc1ccc(SCc2nc3ccc(Cl)cc3c(=O)[nH]2)cc1,3.8774000000000024
+31235,Please optimize the molecule Cc1nc(N(C)C)sc1C[NH+](C)[C@H]1CCCc2c1cnn2C to have a lower LogP value.,Cc1nc(N(C)C)sc1C[NH+](C)[C@H]1CCCc2c1cnn2C,1.3433199999999994
+41007,Please modify the molecule C[C@@H]([NH+]1CCC(n2cccc2C(=O)[O-])CC1)C1(C)CC1 to decrease its LogP value.,C[C@@H]([NH+]1CCC(n2cccc2C(=O)[O-])CC1)C1(C)CC1,0.26
+46752,Please modify the molecule O=c1occ(CN2CCN(c3ccccc3)CC2)c([O-])c1CN1CCOCC1 to decrease its LogP value.,O=c1occ(CN2CCN(c3ccccc3)CC2)c([O-])c1CN1CCOCC1,0.8677999999999999
+47940,Optimize the molecule C[C@@H]1C[C@@H]2CCCC[C@@H]2[NH+]1Cc1n[nH]c(=O)[nH]1 to have a lower LogP value.,C[C@@H]1C[C@@H]2CCCC[C@@H]2[NH+]1Cc1n[nH]c(=O)[nH]1,-0.1660999999999987
+135193,Please modify the molecule Cc1cc(F)ccc1CCNC(=O)C(=O)Nc1nn(C(C)C)cc1C#N to decrease its LogP value.,Cc1cc(F)ccc1CCNC(=O)C(=O)Nc1nn(C(C)C)cc1C#N,2.0805999999999996
+3408,Please optimize the molecule Cc1ccc(C(=O)N[C@@H](C)c2ccccc2)cc1S(=O)(=O)N1CCOCC1 to have a lower LogP value.,Cc1ccc(C(=O)N[C@@H](C)c2ccccc2)cc1S(=O)(=O)N1CCOCC1,2.506920000000001
+136475,Modify the molecule CCN(Cc1ccccc1)S(=O)(=O)[C@H]1C=NC(C(=O)OC)=C1 to have a higher LogP value.,CCN(Cc1ccccc1)S(=O)(=O)[C@H]1C=NC(C(=O)OC)=C1,1.3482
+51657,Please modify the molecule O=C(N/N=C\c1ccc(OCc2cccc(F)c2)cc1)c1cccs1 to increase its LogP value.,O=C(N/N=C\c1ccc(OCc2cccc(F)c2)cc1)c1cccs1,4.230100000000003
+198012,Optimize the molecule C[C@@H]1CCC[C@@H]1NC(=O)C(=O)Nc1ccc(COc2ccccc2)cc1 to have a lower LogP value.,C[C@@H]1CCC[C@@H]1NC(=O)C(=O)Nc1ccc(COc2ccccc2)cc1,3.5089000000000024
+179973,Modify the molecule COc1ccc(F)c(N[C@H](C[NH3+])C2CCCCC2)c1 to decrease its LogP value.,COc1ccc(F)c(N[C@H](C[NH3+])C2CCCCC2)c1,2.4370000000000003
+248327,Please optimize the molecule CC[NH+](CC)C(C)(C)C(=O)Cc1ccc(C)c(C)c1 to have a higher LogP value.,CC[NH+](CC)C(C)(C)C(=O)Cc1ccc(C)c(C)c1,2.11834
+101513,Please optimize the molecule C[C@H]1Sc2ccc(C(=O)NCc3ccc4c(n3)CCCC4=O)cc2NC1=O to have a lower LogP value.,C[C@H]1Sc2ccc(C(=O)NCc3ccc4c(n3)CCCC4=O)cc2NC1=O,2.963300000000001
+5301,Modify the molecule CN(Cc1nccn1Cc1ccccc1)C(=O)c1ccc(C(N)=O)cc1 to increase its LogP value.,CN(Cc1nccn1Cc1ccccc1)C(=O)c1ccc(C(N)=O)cc1,2.3025
+58150,Modify the molecule Cc1cc(CNS(=O)(=O)CC(C)C)c(C)o1 to have a lower LogP value.,Cc1cc(CNS(=O)(=O)CC(C)C)c(C)o1,1.97184
+91813,Please modify the molecule CC[NH2+][C@H](c1cc(C)oc1C)C1(CC)CCCC1 to increase its LogP value.,CC[NH2+][C@H](c1cc(C)oc1C)C1(CC)CCCC1,3.491240000000002
+165059,Modify the molecule Cc1cc2c(SCC(=O)N[C@H](C)C(=O)N(C)C)ncnc2s1 to have a higher LogP value.,Cc1cc2c(SCC(=O)N[C@H](C)C(=O)N(C)C)ncnc2s1,1.6847199999999996
+140542,Please optimize the molecule CCC[NH2+][C@H](CC(F)(F)F)[C@@H]1CCCc2cccnc21 to have a lower LogP value.,CCC[NH2+][C@H](CC(F)(F)F)[C@@H]1CCCc2cccnc21,2.7959000000000014
+112915,Modify the molecule COC(=O)[C@@H](NC[C@H]1CCCO1)c1ccccc1Cl to have a higher LogP value.,COC(=O)[C@@H](NC[C@H]1CCCO1)c1ccccc1Cl,2.3226999999999993
+64320,Please optimize the molecule Nc1nc2n(n1)[C@H](c1ccccc1Br)C1=C(C[C@@H](c3cccs3)CC1=O)N2 to have a lower LogP value.,Nc1nc2n(n1)[C@H](c1ccccc1Br)C1=C(C[C@@H](c3cccs3)CC1=O)N2,4.100000000000002
+103104,Modify the molecule CC1=C(C(N)=O)[C@H](c2cccs2)N2NC(c3ccccc3Cl)=NC2=N1 to decrease its LogP value.,CC1=C(C(N)=O)[C@H](c2cccs2)N2NC(c3ccccc3Cl)=NC2=N1,2.8385000000000007
+147238,Please optimize the molecule COc1ccc([C@@H]2C[C@H](C)N(C(=O)c3cc(F)ccc3C)C2)cc1 to have a lower LogP value.,COc1ccc([C@@H]2C[C@H](C)N(C(=O)c3cc(F)ccc3C)C2)cc1,4.1609200000000035
+210904,Please optimize the molecule CC(C)(CNC(=O)NCc1c(F)cccc1OC(F)F)c1ccncc1 to have a lower LogP value.,CC(C)(CNC(=O)NCc1c(F)cccc1OC(F)F)c1ccncc1,3.5991000000000026
+189967,Modify the molecule CC(C)(C)OC(=O)N1CCC[C@@H](C[NH+]2CCC[C@H](c3ncc[nH]3)C2)C1 to decrease its LogP value.,CC(C)(C)OC(=O)N1CCC[C@@H](C[NH+]2CCC[C@H](c3ncc[nH]3)C2)C1,1.8190999999999997
+219895,Modify the molecule COC[C@@H](O)CN1CCC([NH2+][C@H]2CC[C@@H](C)C2)CC1 to increase its LogP value.,COC[C@@H](O)CN1CCC([NH2+][C@H]2CC[C@@H](C)C2)CC1,0.21010000000000173
+42296,Optimize the molecule COc1cccc(CNC(=O)C[C@@H]2CSc3nc4c(cnn4-c4cccc(Cl)c4)c(=O)n32)c1 to have a higher LogP value.,COc1cccc(CNC(=O)C[C@@H]2CSc3nc4c(cnn4-c4cccc(Cl)c4)c(=O)n32)c1,3.597500000000002
+202897,Modify the molecule COC(=O)CSc1nc2[nH]ncc2c(=O)n1-c1ccccc1 to increase its LogP value.,COC(=O)CSc1nc2[nH]ncc2c(=O)n1-c1ccccc1,1.3738999999999997
+65204,Modify the molecule COc1ccccc1NC(=O)N1CCC(Oc2ccccc2)CC1 to decrease its LogP value.,COc1ccccc1NC(=O)N1CCC(Oc2ccccc2)CC1,3.770500000000003
+4035,Please modify the molecule O=C(N=C1NCCCCCN1)c1ccc(Br)cc1 to increase its LogP value.,O=C(N=C1NCCCCCN1)c1ccc(Br)cc1,2.3084
+108909,Modify the molecule Cc1nc(C[NH+]2CCC[C@H](NCCOc3ccccc3C)C2)no1 to have a lower LogP value.,Cc1nc(C[NH+]2CCC[C@H](NCCOc3ccccc3C)C2)no1,0.9023400000000013
+211486,Optimize the molecule O=C(NCc1cc2ccccc2o1)C(=O)Nc1ccc(F)c(F)c1F to have a higher LogP value.,O=C(NCc1cc2ccccc2o1)C(=O)Nc1ccc(F)c(F)c1F,3.1050000000000004
+125884,Optimize the molecule CCc1nc([C@H](C)NC(=O)c2nc(C3CC3)n3ccccc23)cs1 to have a lower LogP value.,CCc1nc([C@H](C)NC(=O)c2nc(C3CC3)n3ccccc23)cs1,3.7216000000000022
+193385,Please modify the molecule COCCCN1C(=O)CC[C@@H](C(=O)[O-])[C@@H]1c1ccc(F)cc1 to decrease its LogP value.,COCCCN1C(=O)CC[C@@H](C(=O)[O-])[C@@H]1c1ccc(F)cc1,0.8918000000000001
+7037,Please optimize the molecule CC(C)N(C(=O)CSC(=S)N1CCCCC1)C(C)C to have a lower LogP value.,CC(C)N(C(=O)CSC(=S)N1CCCCC1)C(C)C,3.1358000000000015
+14866,Modify the molecule COc1ccc([C@@H]2CCCCCN2C(=O)Cn2ccccc2=O)cc1 to have a lower LogP value.,COc1ccc([C@@H]2CCCCCN2C(=O)Cn2ccccc2=O)cc1,3.0008000000000017
+208417,Modify the molecule O=c1[nH]c(CCl)nc2ccc(O)cc12 to increase its LogP value.,O=c1[nH]c(CCl)nc2ccc(O)cc12,1.3675
+123715,Modify the molecule CC1CCN(S(=O)(=O)c2ccc(C(=O)N(C)Cc3cccc(Cl)c3)cc2)CC1 to decrease its LogP value.,CC1CCN(S(=O)(=O)c2ccc(C(=O)N(C)Cc3cccc(Cl)c3)cc2)CC1,4.0328000000000035
+106002,Please modify the molecule Cn1ccnc1S[C@H]1CC[C@@](C#N)(NC2CC2)C1 to increase its LogP value.,Cn1ccnc1S[C@H]1CC[C@@](C#N)(NC2CC2)C1,2.0790800000000003
+104623,Modify the molecule COc1ccc(CN2CC[NH+](CC(C)C)[C@H](CCO)C2)c(C)c1C to have a lower LogP value.,COc1ccc(CN2CC[NH+](CC(C)C)[C@H](CCO)C2)c(C)c1C,1.4195400000000007
+22270,Modify the molecule CC1(C)[C@H](N2CCOCC2)[C@H](Cl)S1(=O)=O to have a higher LogP value.,CC1(C)[C@H](N2CCOCC2)[C@H](Cl)S1(=O)=O,0.4591000000000003
+54842,Modify the molecule CNC(=O)[C@@H](CC(C)C)N[C@H](C)C[C@@H]1CCCCC[NH2+]1 to have a higher LogP value.,CNC(=O)[C@@H](CC(C)C)N[C@H](C)C[C@@H]1CCCCC[NH2+]1,1.021300000000001
+153449,Optimize the molecule Cc1cc(CNC(=O)c2n[nH]c(C(C)C)n2)cc(C)c1F to have a lower LogP value.,Cc1cc(CNC(=O)c2n[nH]c(C(C)C)n2)cc(C)c1F,2.614040000000001
+32898,Modify the molecule OC[C@H](C[C@H]1CCCO1)c1ccccc1F to increase its LogP value.,OC[C@H](C[C@H]1CCCO1)c1ccccc1F,2.470700000000001
+186346,Modify the molecule CCn1nc(C)cc1C(=O)NCC(=O)NCc1cccnc1 to decrease its LogP value.,CCn1nc(C)cc1C(=O)NCC(=O)NCc1cccnc1,0.6526199999999993
+177140,Please modify the molecule Cc1ccc(OCC(=O)N2CCN(c3ccc([N+](=O)[O-])c(N4CCOCC4)c3)CC2)cc1 to increase its LogP value.,Cc1ccc(OCC(=O)N2CCN(c3ccc([N+](=O)[O-])c(N4CCOCC4)c3)CC2)cc1,2.4674200000000006
+237660,Modify the molecule C[C@H]1Cc2ccccc2N1C(=O)CNCC[NH+](C)C to have a higher LogP value.,C[C@H]1Cc2ccccc2N1C(=O)CNCC[NH+](C)C,-0.3016999999999974
+222127,Modify the molecule COc1ccccc1NC(=O)C[NH+]1CCC(c2nc3ccccc3[nH]2)CC1 to decrease its LogP value.,COc1ccccc1NC(=O)C[NH+]1CCC(c2nc3ccccc3[nH]2)CC1,1.9724999999999993
+110735,Modify the molecule O=C(c1nn2c(c1Cl)N[C@H](c1ccc(Br)cc1)C[C@@H]2C(F)(F)F)N1CCOCC1 to have a lower LogP value.,O=C(c1nn2c(c1Cl)N[C@H](c1ccc(Br)cc1)C[C@@H]2C(F)(F)F)N1CCOCC1,4.431700000000003
+121046,Modify the molecule CCCc1n[nH]c2c1[C@@H](c1ccc(SC)cc1)C(C#N)=C(N)O2 to decrease its LogP value.,CCCc1n[nH]c2c1[C@@H](c1ccc(SC)cc1)C(C#N)=C(N)O2,3.3022800000000014
+209988,Modify the molecule O=C(c1cnc(Nc2ccccc2)nc1)N1CCC2(CC[NH2+]CC2)CC1 to decrease its LogP value.,O=C(c1cnc(Nc2ccccc2)nc1)N1CCC2(CC[NH2+]CC2)CC1,1.7997999999999996
+221667,Optimize the molecule Cc1ccc2nc(C)cc(C(=O)Nc3ccc(C)c(S(N)(=O)=O)c3)c2c1 to have a higher LogP value.,Cc1ccc2nc(C)cc(C(=O)Nc3ccc(C)c(S(N)(=O)=O)c3)c2c1,3.0597600000000007
+226882,Please modify the molecule CSc1cccc(NC(=O)[C@H]2CCCN2S(=O)(=O)c2ccc3c(c2)C[C@H](C)N3C(C)=O)c1 to decrease its LogP value.,CSc1cccc(NC(=O)[C@H]2CCCN2S(=O)(=O)c2ccc3c(c2)C[C@H](C)N3C(C)=O)c1,3.4978000000000025
+117911,Modify the molecule O=C(C1=C([O-])C(=O)N(c2cccc(C(F)(F)F)c2)[C@@H]1c1cccc([N+](=O)[O-])c1)c1ccccc1 to have a higher LogP value.,O=C(C1=C([O-])C(=O)N(c2cccc(C(F)(F)F)c2)[C@@H]1c1cccc([N+](=O)[O-])c1)c1ccccc1,4.198800000000003
+230216,Please modify the molecule O=C1C[C@H](c2cccc(O)c2)[C@@H]2C(=O)N=C(SCc3ccc(F)cc3)N=C2N1 to decrease its LogP value.,O=C1C[C@H](c2cccc(O)c2)[C@@H]2C(=O)N=C(SCc3ccc(F)cc3)N=C2N1,2.9791000000000007
+194593,Modify the molecule CCN(C[C@H](C)C(=O)OC)C(=O)c1c(C)cc(C)c([N+](=O)[O-])c1C to have a lower LogP value.,CCN(C[C@H](C)C(=O)OC)C(=O)c1c(C)cc(C)c([N+](=O)[O-])c1C,2.791260000000001
+157356,Please modify the molecule CCc1nc(CNC(=O)c2ccc(C)nc2)cs1 to increase its LogP value.,CCc1nc(CNC(=O)c2ccc(C)nc2)cs1,2.3389200000000008
+22605,Please modify the molecule CC[C@@H](NC(=O)[C@@H](C)NC1=NS(=O)(=O)c2ccccc21)c1ccc(C)cc1 to decrease its LogP value.,CC[C@@H](NC(=O)[C@@H](C)NC1=NS(=O)(=O)c2ccccc21)c1ccc(C)cc1,2.689520000000001
+140692,Please optimize the molecule COC(=O)[C@H](Nc1ncnc(OC(C)C)c1N)C(C)C to have a higher LogP value.,COC(=O)[C@H](Nc1ncnc(OC(C)C)c1N)C(C)C,1.4554999999999991
+235042,Modify the molecule Cc1cn2c([nH+]1)CC[C@H](NC(=O)[C@H](C)c1cccs1)C2 to increase its LogP value.,Cc1cn2c([nH+]1)CC[C@H](NC(=O)[C@H](C)c1cccs1)C2,1.9068199999999993
+19720,Modify the molecule CC[C@@H](Nc1cc(C)ccc1N)c1cccs1 to have a lower LogP value.,CC[C@@H](Nc1cc(C)ccc1N)c1cccs1,4.201920000000003
+56523,Optimize the molecule CC(C)C[C@@H]1NC(=O)[C@H]2CN(Cc3cccc4ncccc34)CCN2C1=O to have a lower LogP value.,CC(C)C[C@@H]1NC(=O)[C@H]2CN(Cc3cccc4ncccc34)CCN2C1=O,1.7920999999999996
+149613,Please optimize the molecule CC[NH2+][C@@H]1[C@H](CN(C)Cc2ccccn2)CCC1(C)C to have a lower LogP value.,CC[NH2+][C@@H]1[C@H](CN(C)Cc2ccccn2)CCC1(C)C,1.9015
+202160,Please modify the molecule CC(C)[C@@H](CS)CN1C(=O)CC(C)(C)C1=O to increase its LogP value.,CC(C)[C@@H](CS)CN1C(=O)CC(C)(C)C1=O,1.9735
+36657,Optimize the molecule COC(=O)[C@@H]1CN(C(=O)c2ncccc2[O-])C[C@H]1C to have a higher LogP value.,COC(=O)[C@@H]1CN(C(=O)c2ncccc2[O-])C[C@H]1C,0.036299999999999555
+99600,Please modify the molecule COC(=O)c1ccc(NC(=O)CN2CCN(c3ccccc3F)CC2)cc1 to decrease its LogP value.,COC(=O)c1ccc(NC(=O)CN2CCN(c3ccccc3F)CC2)cc1,2.373
+160493,Optimize the molecule Cc1cccc(-n2c(SCC(N)=O)nc3sc(C)c(C)c3c2=O)c1C to have a higher LogP value.,Cc1cccc(-n2c(SCC(N)=O)nc3sc(C)c(C)c3c2=O)c1C,3.258280000000002
+162175,Please optimize the molecule O=C(NNC(=O)c1ccnc2ccccc12)c1ccc(Cl)cc1 to have a higher LogP value.,O=C(NNC(=O)c1ccnc2ccccc12)c1ccc(Cl)cc1,2.963000000000001
+10502,Please modify the molecule CC(=O)N[C@@H](CC(=O)Nc1ccccc1I)c1ccccc1 to decrease its LogP value.,CC(=O)N[C@@H](CC(=O)Nc1ccccc1I)c1ccccc1,3.497200000000002
+246036,Please optimize the molecule COc1ccc(C[NH+]2CCC[C@@H]([NH+]3CCCC3)C2)cc1SC to have a lower LogP value.,COc1ccc(C[NH+]2CCC[C@@H]([NH+]3CCCC3)C2)cc1SC,0.6431000000000013
+83451,Please optimize the molecule O=C([C@@H]1CC[C@@H]2CCCC[C@@H]2[NH2+]1)N1CCc2ccccc21 to have a lower LogP value.,O=C([C@@H]1CC[C@@H]2CCCC[C@@H]2[NH2+]1)N1CCc2ccccc21,1.8603
+54042,Modify the molecule COc1ccc(-c2n[nH]c(S[C@H](C)C(=O)Nc3cc(Cl)ccc3OC)n2)cc1 to decrease its LogP value.,COc1ccc(-c2n[nH]c(S[C@H](C)C(=O)Nc3cc(Cl)ccc3OC)n2)cc1,4.261600000000002
+14148,Modify the molecule CCOC(=O)/C(CC)=C(\C)NNC(=O)c1ccccc1I to decrease its LogP value.,CCOC(=O)/C(CC)=C(\C)NNC(=O)c1ccccc1I,2.7727000000000013
+88625,Modify the molecule O=C1c2cccc3c(N4CCCC4)ccc(c23)C(=O)N1CCc1ccccc1 to have a higher LogP value.,O=C1c2cccc3c(N4CCCC4)ccc(c23)C(=O)N1CCc1ccccc1,4.278700000000004
+202858,Optimize the molecule COc1ccc(Cl)cc1NC(=O)/C(C#N)=C/c1ccc(N2CCOCC2)o1 to have a higher LogP value.,COc1ccc(Cl)cc1NC(=O)/C(C#N)=C/c1ccc(N2CCOCC2)o1,3.3238800000000017
+192146,Optimize the molecule CCn1nc(C(C)C)cc1C(=O)OCC(=O)N1CCCCCC1 to have a lower LogP value.,CCn1nc(C(C)C)cc1C(=O)OCC(=O)N1CCCCCC1,2.5858000000000008
+200845,Modify the molecule COc1ccc(Cl)cc1NC(=O)c1c(-n2cnnn2)sc2c1CCC2 to decrease its LogP value.,COc1ccc(Cl)cc1NC(=O)c1c(-n2cnnn2)sc2c1CCC2,3.126800000000001
+141861,Please modify the molecule O=C(COc1ccc(F)cc1)N1CCN(c2cc(N3CCCCC3)c(F)cc2[N+](=O)[O-])CC1 to increase its LogP value.,O=C(COc1ccc(F)cc1)N1CCN(c2cc(N3CCCCC3)c(F)cc2[N+](=O)[O-])CC1,3.590900000000002
+139333,Modify the molecule COCC[C@]1(C)CC(=O)NC(=O)[C@H]1c1cccc(C)c1 to decrease its LogP value.,COCC[C@]1(C)CC(=O)NC(=O)[C@H]1c1cccc(C)c1,2.1679199999999996
+166695,Modify the molecule O=C(C=C1CCSCC1)Nc1ccc(Cl)c(Cl)c1 to decrease its LogP value.,O=C(C=C1CCSCC1)Nc1ccc(Cl)c(Cl)c1,4.385300000000003
+182487,Modify the molecule N#C[C@H](NS(=O)(=O)c1ccc(Cl)s1)c1ccccc1F to have a lower LogP value.,N#C[C@H](NS(=O)(=O)c1ccc(Cl)s1)c1ccccc1F,3.083780000000001
+109964,Please modify the molecule COc1cc(I)c(Cl)cc1C(=O)NCCC[C@H]1CCC[C@@H]1O to decrease its LogP value.,COc1cc(I)c(Cl)cc1C(=O)NCCC[C@H]1CCC[C@@H]1O,3.6242000000000023
+62659,Optimize the molecule COCCC1(C(=O)N[C@@H](CO)c2ccco2)CCC1 to have a higher LogP value.,COCCC1(C(=O)N[C@@H](CO)c2ccco2)CCC1,1.636
+42580,Modify the molecule Cc1sc2nc(CSc3ccc(C(C)C)cc3)[nH]c(=O)c2c1C to have a lower LogP value.,Cc1sc2nc(CSc3ccc(C(C)C)cc3)[nH]c(=O)c2c1C,5.017140000000004
+210261,Modify the molecule C[C@H](Br)[C@H](C)c1ccc(Cl)cc1 to have a lower LogP value.,C[C@H](Br)[C@H](C)c1ccc(Cl)cc1,4.226900000000003
+132355,Optimize the molecule CCN1CCO[C@@H]([C@@H](CCc2ccsc2)[NH2+]C)C1 to have a higher LogP value.,CCN1CCO[C@@H]([C@@H](CCc2ccsc2)[NH2+]C)C1,0.9632000000000004
+207344,Please optimize the molecule CO[C@H]1CCCC[C@H]1NC(=O)N[C@@H](C)c1cccc(-n2ccnc2)c1 to have a lower LogP value.,CO[C@H]1CCCC[C@H]1NC(=O)N[C@@H](C)c1cccc(-n2ccnc2)c1,3.190100000000002
+236142,Modify the molecule CC[C@H]1COCCN1C(=O)N[C@@H](C)c1ccc(S(C)(=O)=O)c(F)c1 to decrease its LogP value.,CC[C@H]1COCCN1C(=O)N[C@@H](C)c1ccc(S(C)(=O)=O)c(F)c1,2.1106000000000003
+245432,Optimize the molecule COc1ccc(CNC(=O)c2cn(C)nc2OC)cc1 to have a lower LogP value.,COc1ccc(CNC(=O)c2cn(C)nc2OC)cc1,1.3673
+207993,Please optimize the molecule CCOC(=O)C1=C(C)Nc2nc(SCc3ccccc3Cl)nn2[C@@H]1c1cccc(O)c1 to have a lower LogP value.,CCOC(=O)C1=C(C)Nc2nc(SCc3ccccc3Cl)nn2[C@@H]1c1cccc(O)c1,4.781400000000004
+125598,Modify the molecule CN(C)C(=O)c1cc2ncc(C(=O)N3CCCC3)cc2n1C to have a lower LogP value.,CN(C)C(=O)c1cc2ncc(C(=O)N3CCCC3)cc2n1C,1.5110999999999999
+216860,Please optimize the molecule C[C@H](NC(=O)Nc1ccccc1SCCC(N)=O)c1ccncc1 to have a higher LogP value.,C[C@H](NC(=O)Nc1ccccc1SCCC(N)=O)c1ccncc1,2.931800000000001
+182514,Please optimize the molecule COCCCNC(=O)CSc1nc2ccccc2c2nc3ccccc3n12 to have a higher LogP value.,COCCCNC(=O)CSc1nc2ccccc2c2nc3ccccc3n12,3.2805000000000017
+249169,Modify the molecule CCc1ccc(CC(CO)(CO)c2ccccc2Cl)cc1 to increase its LogP value.,CCc1ccc(CC(CO)(CO)c2ccccc2Cl)cc1,3.3675000000000015
+216660,Modify the molecule COc1cc(F)cc(NC(=O)NCc2ncn(C)n2)c1 to decrease its LogP value.,COc1cc(F)cc(NC(=O)NCc2ncn(C)n2)c1,1.2844999999999998
+159750,Modify the molecule CC[C@@H]1Oc2ccccc2N(CC(=O)Nc2ccccc2OC)C1=O to decrease its LogP value.,CC[C@@H]1Oc2ccccc2N(CC(=O)Nc2ccccc2OC)C1=O,2.837900000000001
+88394,Please optimize the molecule C[C@@H]1CCC[NH+](CC(=O)Nc2nc(-c3ccc(F)cc3)cs2)C1 to have a lower LogP value.,C[C@@H]1CCC[NH+](CC(=O)Nc2nc(-c3ccc(F)cc3)cs2)C1,2.2024999999999997
+8475,Please optimize the molecule Nc1ccc(Cl)cc1SCCC(=O)NC1CC1 to have a lower LogP value.,Nc1ccc(Cl)cc1SCCC(=O)NC1CC1,2.6830000000000007
+88540,Optimize the molecule COc1cc(C)c(N)cc1S(=O)(=O)N[C@@H]1CC[C@H](C)[C@@H]1C to have a lower LogP value.,COc1cc(C)c(N)cc1S(=O)(=O)N[C@@H]1CC[C@H](C)[C@@H]1C,2.2987200000000003
+232275,Optimize the molecule Cc1nn(-c2ncccn2)c2c1[C@@H](c1cccc(OCC(C)C)c1)SCC(O)=N2 to have a lower LogP value.,Cc1nn(-c2ncccn2)c2c1[C@@H](c1cccc(OCC(C)C)c1)SCC(O)=N2,4.429720000000003
+230522,Please optimize the molecule C[C@@H](O)[C@@H](NC(=O)CCOc1ccc(Br)cc1)C(=O)[O-] to have a higher LogP value.,C[C@@H](O)[C@@H](NC(=O)CCOc1ccc(Br)cc1)C(=O)[O-],-0.16650000000000076
+137687,Please optimize the molecule O=C([O-])Cn1nnnc1Sc1ncnc2c1CCCC2 to have a higher LogP value.,O=C([O-])Cn1nnnc1Sc1ncnc2c1CCCC2,-0.7570000000000008
+125411,Optimize the molecule O=C(NCc1ncccc1F)N[C@H]1CCCC[C@H]1OC1CCCC1 to have a higher LogP value.,O=C(NCc1ncccc1F)N[C@H]1CCCC[C@H]1OC1CCCC1,3.290300000000002
+157405,Modify the molecule COc1cc(C(=O)Nc2nc3ccc(S(C)(=O)=O)cc3s2)ccc1OC(C)C to have a higher LogP value.,COc1cc(C(=O)Nc2nc3ccc(S(C)(=O)=O)cc3s2)ccc1OC(C)C,3.747900000000003
+2648,Modify the molecule Cc1noc(C)c1CCCNC(=O)c1c(Cl)ccc(Cl)c1Cl to have a lower LogP value.,Cc1noc(C)c1CCCNC(=O)c1c(Cl)ccc(Cl)c1Cl,4.614240000000003
+108390,Modify the molecule COc1ccc2[nH]cc(CC(=O)NC[C@](C)(O)c3ccsc3)c2c1 to decrease its LogP value.,COc1ccc2[nH]cc(CC(=O)NC[C@](C)(O)c3ccsc3)c2c1,2.804400000000001
+86851,Please optimize the molecule COC[C@H](Nc1ncnc2ncccc12)c1ccc(F)c(F)c1 to have a higher LogP value.,COC[C@H](Nc1ncnc2ncccc12)c1ccc(F)c(F)c1,3.1026000000000016
+111651,Please optimize the molecule CCOc1ccccc1C(=O)N1CCN([C@@H](C)C(=O)N2CCCC2)CC1 to have a higher LogP value.,CCOc1ccccc1C(=O)N1CCN([C@@H](C)C(=O)N2CCCC2)CC1,1.8539999999999999
+194243,Optimize the molecule Cc1ccc(F)c(NC(=O)[C@H](C)N2C(=O)c3cc(Cl)c(Cl)cc3C2=O)c1 to have a lower LogP value.,Cc1ccc(F)c(NC(=O)[C@H](C)N2C(=O)c3cc(Cl)c(Cl)cc3C2=O)c1,4.064120000000003
+129114,Modify the molecule NN[C@@H]1CS(=O)(=O)C[C@H]1O to decrease its LogP value.,NN[C@@H]1CS(=O)(=O)C[C@H]1O,-2.392399999999999
+177748,Modify the molecule C[C@@H]1CCCC[NH+]1CCCNC(=O)c1cccc(-c2cc(N3CCCC3)ncn2)c1 to increase its LogP value.,C[C@@H]1CCCC[NH+]1CCCNC(=O)c1cccc(-c2cc(N3CCCC3)ncn2)c1,2.3209999999999997
+16572,Modify the molecule CC[C@H]1SC(=S)N(CC(=O)Nc2cc(C)ccc2C)C1=O to increase its LogP value.,CC[C@H]1SC(=S)N(CC(=O)Nc2cc(C)ccc2C)C1=O,2.880840000000001
+69910,Optimize the molecule CC(C)C[NH+]1CCCC[C@H]1C(=O)NC[C@@H]1CCN(c2ccc(F)c(F)c2)C1 to have a higher LogP value.,CC(C)C[NH+]1CCCC[C@H]1C(=O)NC[C@@H]1CCN(c2ccc(F)c(F)c2)C1,2.0006999999999997
+133782,Modify the molecule Cc1cc(S(=O)(=O)N[C@@H](CO)c2ccc(Cl)c(F)c2)sc1C to have a lower LogP value.,Cc1cc(S(=O)(=O)N[C@@H](CO)c2ccc(Cl)c(F)c2)sc1C,3.169340000000002
+22142,Modify the molecule CC(C)(C)OC(=O)N1CCC[C@@H]1[C@@H]1CCCCN1S(=O)(=O)c1cccc(S(N)(=O)=O)c1 to increase its LogP value.,CC(C)(C)OC(=O)N1CCC[C@@H]1[C@@H]1CCCCN1S(=O)(=O)c1cccc(S(N)(=O)=O)c1,2.276700000000001
+151607,Optimize the molecule Cc1nc(C)c(C(=O)NC[C@H](O)c2c(F)cccc2F)s1 to have a higher LogP value.,Cc1nc(C)c(C(=O)NC[C@H](O)c2c(F)cccc2F)s1,2.5015400000000003
+195145,Modify the molecule O=C(Nc1ccc(O)c(C(=O)[O-])c1)c1ccc(Br)o1 to increase its LogP value.,O=C(Nc1ccc(O)c(C(=O)[O-])c1)c1ccc(Br)o1,1.3635
+241115,Optimize the molecule O=S(=O)(Nc1cc(F)ccc1F)c1ccccc1Br to have a lower LogP value.,O=S(=O)(Nc1cc(F)ccc1F)c1ccccc1Br,3.528100000000001
+47762,Modify the molecule Oc1ccc([C@H]2Nc3c(F)cccc3[C@H]3C=CC[C@H]32)cc1 to decrease its LogP value.,Oc1ccc([C@H]2Nc3c(F)cccc3[C@H]3C=CC[C@H]32)cc1,4.357800000000003
+127744,Optimize the molecule Cc1n[nH]c(C)c1[C@@H]1CCCN1C(=O)Nc1ccc(OC(C)C)c(Cl)c1 to have a lower LogP value.,Cc1n[nH]c(C)c1[C@@H]1CCCN1C(=O)Nc1ccc(OC(C)C)c(Cl)c1,4.836140000000004
+98719,Please optimize the molecule CCSCC[C@H](C)NC(=O)C(=O)Nc1ccc2c(c1)oc(=O)n2C to have a lower LogP value.,CCSCC[C@H](C)NC(=O)C(=O)Nc1ccc2c(c1)oc(=O)n2C,1.7178999999999993
+205566,Optimize the molecule CCCN(CCO)C[C@@H]1CCC(C)(C)[C@@H]1[NH3+] to have a lower LogP value.,CCCN(CCO)C[C@@H]1CCC(C)(C)[C@@H]1[NH3+],0.7374000000000007
+18515,Modify the molecule CCOC(=O)[C@]1(N)CC[C@@H](Sc2nnc(N(C)C)s2)C1 to decrease its LogP value.,CCOC(=O)[C@]1(N)CC[C@@H](Sc2nnc(N(C)C)s2)C1,1.5092999999999992
+245019,Modify the molecule O=C(Nc1nc(-c2cccc(F)c2)cs1)c1csc(-c2nc[nH]n2)n1 to increase its LogP value.,O=C(Nc1nc(-c2cccc(F)c2)cs1)c1csc(-c2nc[nH]n2)n1,3.443100000000001
+140921,Modify the molecule COC(=O)CSc1nnc(-c2ccccc2)n1-c1ccccc1C to have a higher LogP value.,COC(=O)CSc1nnc(-c2ccccc2)n1-c1ccccc1C,3.5078200000000024
+221633,Optimize the molecule CN(Cc1ccc2c(c1)OCO2)S(=O)(=O)c1ncn(C)c1Cl to have a higher LogP value.,CN(Cc1ccc2c(c1)OCO2)S(=O)(=O)c1ncn(C)c1Cl,1.6228999999999998
+108517,Modify the molecule CN(C[C@@H](O)C1CC1)C(=O)c1c(O)cc(F)cc1F to have a higher LogP value.,CN(C[C@@H](O)C1CC1)C(=O)c1c(O)cc(F)cc1F,1.5133
+33870,Optimize the molecule Cn1c(=O)c2c(nc(N/N=C/c3ccccc3O)n2CCO)n(C)c1=O to have a higher LogP value.,Cn1c(=O)c2c(nc(N/N=C/c3ccccc3O)n2CCO)n(C)c1=O,-0.4224000000000001
+27962,Optimize the molecule C[C@H](NC(=O)C[NH+]1CCCC1)c1ccccc1Cl to have a lower LogP value.,C[C@H](NC(=O)C[NH+]1CCCC1)c1ccccc1Cl,1.1959000000000006
+134541,Modify the molecule COc1ccc(NC(=O)N2C[C@@H](C)C[C@H](C)C2)c(OC)c1OC to have a higher LogP value.,COc1ccc(NC(=O)N2C[C@@H](C)C[C@H](C)C2)c(OC)c1OC,3.2222000000000017
+134033,Modify the molecule CN(C(=O)NC[C@H]1COc2ccccc2O1)[C@@H]1CCS(=O)(=O)C1 to increase its LogP value.,CN(C(=O)NC[C@H]1COc2ccccc2O1)[C@@H]1CCS(=O)(=O)C1,0.6548999999999998
+71164,Please optimize the molecule CCNC(=O)[C@@H]1CCC[NH+](Cn2nc(-c3ccc(OC)cc3)n(C)c2=S)C1 to have a higher LogP value.,CCNC(=O)[C@@H]1CCC[NH+](Cn2nc(-c3ccc(OC)cc3)n(C)c2=S)C1,1.015190000000001
+35413,Modify the molecule Cn1ccnc1[C@H](O)C1CC[NH+](C[C@H]2CC=CCC2)CC1 to have a higher LogP value.,Cn1ccnc1[C@H](O)C1CC[NH+](C[C@H]2CC=CCC2)CC1,1.1046999999999993
+230139,Please optimize the molecule Cc1nn(Cc2ccccc2)c(C)c1CNC(=O)NCCO to have a lower LogP value.,Cc1nn(Cc2ccccc2)c(C)c1CNC(=O)NCCO,1.3397399999999997
+243228,Optimize the molecule CC[C@@H](C)N1C(=O)[C@H]2[C@@H](C1=O)[C@@H](C)N[C@@]21C(=O)Nc2ccc(Cl)cc21 to have a lower LogP value.,CC[C@@H](C)N1C(=O)[C@H]2[C@@H](C1=O)[C@@H](C)N[C@@]21C(=O)Nc2ccc(Cl)cc21,1.8787999999999996
+111281,Optimize the molecule COC(=O)/C=c1/sc2n(c1=O)C[NH+]([C@H]1CCC[C@@H](C)[C@H]1C)CN=2 to have a higher LogP value.,COC(=O)/C=c1/sc2n(c1=O)C[NH+]([C@H]1CCC[C@@H](C)[C@H]1C)CN=2,-0.8788999999999976
+207153,Optimize the molecule Cc1ccc(NC(=O)N2CCc3cn(C)c4cccc(c34)C2)cc1F to have a higher LogP value.,Cc1ccc(NC(=O)N2CCc3cn(C)c4cccc(c34)C2)cc1F,4.216020000000003
+205242,Modify the molecule CCN1C[C@@H](C(=O)[O-])CC1=O to decrease its LogP value.,CCN1C[C@@H](C(=O)[O-])CC1=O,-1.395299999999999
+179557,Modify the molecule O=C(c1c[nH]c2ccccc12)[C@H](NC[C@@H]1CCCO1)c1ccccc1 to increase its LogP value.,O=C(c1c[nH]c2ccccc12)[C@H](NC[C@@H]1CCCO1)c1ccccc1,3.8605000000000027
+136144,Optimize the molecule Cc1nc([C@H](Cc2ccsc2)NC(=O)C[C@@H]2C(=O)NCC[NH+]2C)sc1C to have a higher LogP value.,Cc1nc([C@H](Cc2ccsc2)NC(=O)C[C@@H]2C(=O)NCC[NH+]2C)sc1C,0.624640000000001
+223904,Please optimize the molecule CCOc1ccc(-n2nnc3c(=O)n(Cc4nc(-c5ccc(CC)cc5)no4)cnc32)cc1 to have a lower LogP value.,CCOc1ccc(-n2nnc3c(=O)n(Cc4nc(-c5ccc(CC)cc5)no4)cnc32)cc1,3.036600000000001
+13850,Modify the molecule COc1ccc2c(c1)CC[C@H]1C2=NN(C(C)=O)[C@H]1c1ccccc1 to decrease its LogP value.,COc1ccc2c(c1)CC[C@H]1C2=NN(C(C)=O)[C@H]1c1ccccc1,3.565100000000003
+106744,Modify the molecule C[C@H](C(=O)NN)[C@H](C)n1cc(C(F)(F)F)cn1 to have a lower LogP value.,C[C@H](C(=O)NN)[C@H](C)n1cc(C(F)(F)F)cn1,1.0889
+216552,Please optimize the molecule CC(=O)c1ccccc1OCCOn1nnc2ccccc21 to have a higher LogP value.,CC(=O)c1ccccc1OCCOn1nnc2ccccc21,2.1414999999999997
+2452,Please optimize the molecule CC(=O)NCCCC(=O)Nc1cc(NC(C)=O)ccc1F to have a lower LogP value.,CC(=O)NCCCC(=O)Nc1cc(NC(C)=O)ccc1F,1.6388999999999996
+202792,Please modify the molecule CCCn1c([C@@H]2CC(=O)N(Cc3ccccc3)C2)nc2ccccc21 to increase its LogP value.,CCCn1c([C@@H]2CC(=O)N(Cc3ccccc3)C2)nc2ccccc21,3.9624000000000033
+151201,Modify the molecule CCNC(=O)[C@@H](C)[NH+]1CCC(n2nccc2NC(=O)c2ccccc2C)CC1 to have a higher LogP value.,CCNC(=O)[C@@H](C)[NH+]1CCC(n2nccc2NC(=O)c2ccccc2C)CC1,1.1882200000000007
+162013,Modify the molecule Cn1cc(C(=O)N2CCC[C@@H](Cn3ccnn3)C2)c(-c2ccccc2)n1 to have a higher LogP value.,Cn1cc(C(=O)N2CCC[C@@H](Cn3ccnn3)C2)c(-c2ccccc2)n1,2.231
+196566,Please modify the molecule O=C([O-])c1ccccc1N1CC[NH+]2CCCC[C@@H]2C1 to decrease its LogP value.,O=C([O-])c1ccccc1N1CC[NH+]2CCCC[C@@H]2C1,-0.6924999999999988
+240835,Please optimize the molecule CC1CC[NH+](CCNS(=O)(=O)c2ccccc2C(F)(F)F)CC1 to have a higher LogP value.,CC1CC[NH+](CCNS(=O)(=O)c2ccccc2C(F)(F)F)CC1,1.2985000000000002
+18790,Please modify the molecule O=C(NN1CCCCC1)[C@H]1C[C@@H]1c1ccc(F)cc1F to increase its LogP value.,O=C(NN1CCCCC1)[C@H]1C[C@@H]1c1ccc(F)cc1F,2.585400000000001
+3277,Please modify the molecule CC[C@@H](C[NH3+])c1nc2cccc(C)c2o1 to increase its LogP value.,CC[C@@H](C[NH3+])c1nc2cccc(C)c2o1,1.8717199999999996
+109397,Modify the molecule CC[C@H]1CCc2sc(C(=O)NC3COC3)cc2C1 to have a higher LogP value.,CC[C@H]1CCc2sc(C(=O)NC3COC3)cc2C1,2.3916000000000004
+39786,Modify the molecule CC(C)c1csc(/C(C#N)=C\c2csc(-c3ccc(F)cc3)n2)n1 to decrease its LogP value.,CC(C)c1csc(/C(C#N)=C\c2csc(-c3ccc(F)cc3)n2)n1,5.593280000000004
+203080,Modify the molecule CC(C)[NH+](CCCO)C[C@@H]1CN(C)CCO1 to increase its LogP value.,CC(C)[NH+](CCCO)C[C@@H]1CN(C)CCO1,-1.0072999999999965
+183706,Please modify the molecule CCC[C@H](C)CC(=O)Nc1cnn(CC(C)C)c1 to decrease its LogP value.,CCC[C@H](C)CC(=O)Nc1cnn(CC(C)C)c1,3.3039000000000023
+108758,Optimize the molecule O=S(=O)(c1ccccc1)[C@@H](c1ccccc1)c1ccccn1 to have a higher LogP value.,O=S(=O)(c1ccccc1)[C@@H](c1ccccc1)c1ccccn1,3.6449000000000025
+90534,Please optimize the molecule C[C@H]1CCC[C@H](CC(=O)Nc2ccc(C(=O)NC3CCOCC3)cc2)C1 to have a higher LogP value.,C[C@H]1CCC[C@H](CC(=O)Nc2ccc(C(=O)NC3CCOCC3)cc2)C1,3.750300000000003
+200952,Modify the molecule CC(=O)O/N=c1\oc2cc3c(cc2c2c1CCC2)CCC(C)(C)O3 to increase its LogP value.,CC(=O)O/N=c1\oc2cc3c(cc2c2c1CCC2)CCC(C)(C)O3,3.403900000000002
+148232,Optimize the molecule CCS[C@H]1CCCC[C@@H]1NC(=O)N1CCC[C@H]([NH+](C)C)C1 to have a lower LogP value.,CCS[C@H]1CCCC[C@@H]1NC(=O)N1CCC[C@H]([NH+](C)C)C1,1.369200000000001
+170630,Please modify the molecule CCOC(=O)c1c(NC(=O)Cn2ccc(=O)c3cccc(F)c32)sc2c1CCCC2 to increase its LogP value.,CCOC(=O)c1c(NC(=O)Cn2ccc(=O)c3cccc(F)c32)sc2c1CCCC2,3.8963000000000036
+19580,Modify the molecule CCC[C@H](CC(=O)OC)NC(=O)c1cnc2ccccn12 to have a higher LogP value.,CCC[C@H](CC(=O)OC)NC(=O)c1cnc2ccccn12,1.7959
+153650,Please optimize the molecule Cc1nc(C)n([C@@H](C)CC(=O)Nc2ccc3c(c2)OC(C)(C)O3)n1 to have a lower LogP value.,Cc1nc(C)n([C@@H](C)CC(=O)Nc2ccc3c(c2)OC(C)(C)O3)n1,2.992040000000001
+47573,Please optimize the molecule O=c1[nH]c(NCc2ccccc2)nc2nccc(-c3ccccc3)c12 to have a lower LogP value.,O=c1[nH]c(NCc2ccccc2)nc2nccc(-c3ccccc3)c12,3.5972000000000026
+63907,Optimize the molecule O=C(NC1CCN(C(=O)c2cc3ccccc3[nH]2)CC1)c1ccncc1 to have a lower LogP value.,O=C(NC1CCN(C(=O)c2cc3ccccc3[nH]2)CC1)c1ccncc1,2.5975
+212684,Please modify the molecule CN(CC(F)F)C(=O)C(=O)Nc1ccc(NC(=O)c2ccccc2)nc1 to increase its LogP value.,CN(CC(F)F)C(=O)C(=O)Nc1ccc(NC(=O)c2ccccc2)nc1,1.9958999999999998
+4153,Optimize the molecule Cc1noc(C)c1CN(C)C(=O)c1cccc(C[S@](C)=O)c1 to have a higher LogP value.,Cc1noc(C)c1CN(C)C(=O)c1cccc(C[S@](C)=O)c1,2.44214
+177746,Optimize the molecule C[C@@H](NC(=O)N1CCN(C(=O)N2CCOCC2)CC1)c1ccccc1 to have a higher LogP value.,C[C@@H](NC(=O)N1CCN(C(=O)N2CCOCC2)CC1)c1ccccc1,1.5270000000000004
+234861,Optimize the molecule O=C(c1ccc(-c2ccccc2F)o1)N1CCN(c2ccccc2O)CC1 to have a lower LogP value.,O=C(c1ccc(-c2ccccc2F)o1)N1CCN(c2ccccc2O)CC1,3.753700000000002
+226379,Modify the molecule C=CCNC(=O)NC(=O)C[NH+]1CCC(C(=O)N2CCCCCC2)CC1 to decrease its LogP value.,C=CCNC(=O)NC(=O)C[NH+]1CCC(C(=O)N2CCCCCC2)CC1,-0.30429999999999735
+18202,Optimize the molecule CCO[C@@H]1CCCN(C(=O)Nc2ccn(CCCOC)n2)C1 to have a higher LogP value.,CCO[C@@H]1CCCN(C(=O)Nc2ccn(CCCOC)n2)C1,1.9523999999999997
+139928,Please optimize the molecule CC(=O)c1cccc(NC(=O)[C@@H](C)Nc2cccc3c2CCCC3)c1 to have a higher LogP value.,CC(=O)c1cccc(NC(=O)[C@@H](C)Nc2cccc3c2CCCC3)c1,4.207100000000003
+249226,Please modify the molecule Cc1ccc(C(=O)NC[C@@H](c2cccs2)S(=O)(=O)c2ccc(Cl)cc2)cc1 to decrease its LogP value.,Cc1ccc(C(=O)NC[C@@H](c2cccs2)S(=O)(=O)c2ccc(Cl)cc2)cc1,4.654920000000004
+91359,Please optimize the molecule CCOCCN(C)C(=O)c1ccn(-c2cc(C)ccc2OC)n1 to have a higher LogP value.,CCOCCN(C)C(=O)c1ccn(-c2cc(C)ccc2OC)n1,2.2978200000000006
+27949,Modify the molecule CCc1[nH+]ccn1Cc1noc(-c2cc(OC)c(OC)c(OC)c2)n1 to have a lower LogP value.,CCc1[nH+]ccn1Cc1noc(-c2cc(OC)c(OC)c(OC)c2)n1,1.9887
+240762,Please optimize the molecule O=C(CSc1ccc(Cl)cc1)Nc1cccc(C(=O)Nc2ccc(C(=O)[O-])cc2)c1 to have a lower LogP value.,O=C(CSc1ccc(Cl)cc1)Nc1cccc(C(=O)Nc2ccc(C(=O)[O-])cc2)c1,3.686600000000001
+104898,Please modify the molecule CN(CC(=O)N1CCCc2cc(S(=O)(=O)N(C)C)ccc21)c1ccccc1 to increase its LogP value.,CN(CC(=O)N1CCCc2cc(S(=O)(=O)N(C)C)ccc21)c1ccccc1,2.3525
+38063,Please modify the molecule Cc1csc(N(C(=O)c2ccc(-n3cccn3)cc2)c2ccccc2)n1 to decrease its LogP value.,Cc1csc(N(C(=O)c2ccc(-n3cccn3)cc2)c2ccccc2)n1,4.615720000000003
+15737,Please modify the molecule Cc1nc(C(F)(F)F)nc(C2=CN=NC2)c1C to increase its LogP value.,Cc1nc(C(F)(F)F)nc(C2=CN=NC2)c1C,2.918940000000001
+140881,Modify the molecule Cc1nn(-c2ccc3nnc(C)n3n2)c2c1[C@H](c1ccccc1OCC(C)C)CC(O)=N2 to increase its LogP value.,Cc1nn(-c2ccc3nnc(C)n3n2)c2c1[C@H](c1ccccc1OCC(C)C)CC(O)=N2,4.085240000000002
+224298,Modify the molecule COc1ccc(/N=C/c2cccc(O)c2)cc1 to increase its LogP value.,COc1ccc(/N=C/c2cccc(O)c2)cc1,3.1514000000000015
+111200,Please modify the molecule Cc1cc([C@H]([NH3+])C2CCCCCC2)sc1Br to decrease its LogP value.,Cc1cc([C@H]([NH3+])C2CCCCCC2)sc1Br,4.072420000000003
+200391,Modify the molecule Cc1oc(C(=O)N(C)[C@H](C)c2ccccc2)cc1S(=O)(=O)N(C)C to decrease its LogP value.,Cc1oc(C(=O)N(C)[C@H](C)c2ccccc2)cc1S(=O)(=O)N(C)C,2.671520000000001
+63223,Optimize the molecule Cc1ccsc1C(=O)OCC(=O)NCc1ccc(C(F)(F)F)cc1 to have a higher LogP value.,Cc1ccsc1C(=O)OCC(=O)NCc1ccc(C(F)(F)F)cc1,3.5485200000000017
+78665,Optimize the molecule O=C(c1ccc(-n2cnnc2)cc1)N1CCN([C@@H]2CCC[C@H]2O)CC1 to have a higher LogP value.,O=C(c1ccc(-n2cnnc2)cc1)N1CCN([C@@H]2CCC[C@H]2O)CC1,0.9384999999999999
+188840,Modify the molecule Cc1occc1-c1nnc(SCC(=O)c2ccc(C(C)C)cc2)o1 to have a higher LogP value.,Cc1occc1-c1nnc(SCC(=O)c2ccc(C(C)C)cc2)o1,4.736420000000003
+118056,Optimize the molecule CC(=S)N(C)c1ccccc1 to have a higher LogP value.,CC(=S)N(C)c1ccccc1,2.4701000000000004
+171069,Modify the molecule CC(=O)Nc1ccc(NC(=O)N[C@@H]2C[C@H]2c2cccc(Cl)c2)cc1 to decrease its LogP value.,CC(=O)Nc1ccc(NC(=O)N[C@@H]2C[C@H]2c2cccc(Cl)c2)cc1,3.9760000000000018
+239705,Optimize the molecule Oc1cccc(-c2cccc(Cl)c2)c1 to have a higher LogP value.,Oc1cccc(-c2cccc(Cl)c2)c1,3.712600000000001
+140122,Optimize the molecule Cc1n[nH]c(C)c1CCC(=O)N1CCO[C@](C)(C(N)=O)C1 to have a higher LogP value.,Cc1n[nH]c(C)c1CCC(=O)N1CCO[C@](C)(C(N)=O)C1,0.06194000000000044
+133880,Please optimize the molecule [O-]c1c(F)cc(C[NH2+][C@@H]2CCC[C@@H](O)C2)cc1F to have a higher LogP value.,[O-]c1c(F)cc(C[NH2+][C@@H]2CCC[C@@H](O)C2)cc1F,0.40529999999999916
+39346,Modify the molecule CNC(=O)[C@@H](NS(=O)(=O)c1cnn(C)c1)c1ccc(F)c(F)c1 to decrease its LogP value.,CNC(=O)[C@@H](NS(=O)(=O)c1cnn(C)c1)c1ccc(F)c(F)c1,0.4639
+107642,Optimize the molecule O=C(NCC[C@@H]1C[C@H]2CC[C@@H]1C2)N1CCCC1 to have a higher LogP value.,O=C(NCC[C@@H]1C[C@H]2CC[C@@H]1C2)N1CCCC1,2.618100000000001
+156399,Please optimize the molecule C[C@@H](O)[C@@H](C)Nc1cnn(C)c1 to have a lower LogP value.,C[C@@H](O)[C@@H](C)Nc1cnn(C)c1,0.6012999999999997
+87904,Modify the molecule CN(CC(C)(C)C[NH3+])C(=O)c1ccc[nH]1 to decrease its LogP value.,CN(CC(C)(C)C[NH3+])C(=O)c1ccc[nH]1,0.35480000000000084
+12617,Modify the molecule Cc1cc(OC[C@@H]2CCCO2)c([C@H](C)[NH3+])cc1F to increase its LogP value.,Cc1cc(OC[C@@H]2CCCO2)c([C@H](C)[NH3+])cc1F,1.9948199999999998
+234275,Modify the molecule Cc1nn(-c2ccccc2)c(C)c1CNCc1c(F)cccc1F to increase its LogP value.,Cc1nn(-c2ccccc2)c(C)c1CNCc1c(F)cccc1F,4.057140000000003
+55866,Please optimize the molecule CCOC(=O)C1=C(C)N/C(=C\c2cccc(Cl)c2)C1=O to have a lower LogP value.,CCOC(=O)C1=C(C)N/C(=C\c2cccc(Cl)c2)C1=O,2.6903000000000006
+159877,Please modify the molecule CCCC[NH+](CC)[C@H]1Cc2ccc(OC)cc2[C@@H]1O to increase its LogP value.,CCCC[NH+](CC)[C@H]1Cc2ccc(OC)cc2[C@@H]1O,1.3582
+156744,Please modify the molecule COc1ccc([C@@H]2[C@H](C(=O)NC[C@](C)(O)C(C)C)CCC(=O)N2C)cc1 to increase its LogP value.,COc1ccc([C@@H]2[C@H](C(=O)NC[C@](C)(O)C(C)C)CCC(=O)N2C)cc1,2.1278999999999995
+21860,Please optimize the molecule CC(C)n1cnnc1S[C@@H](C)c1ccc(Cl)c(Cl)c1 to have a lower LogP value.,CC(C)n1cnnc1S[C@@H](C)c1ccc(Cl)c(Cl)c1,5.0191000000000034
+88255,Modify the molecule Cc1n[nH]c(-n2cnnc2)c1NC(=O)c1ccccc1Cl to decrease its LogP value.,Cc1n[nH]c(-n2cnnc2)c1NC(=O)c1ccccc1Cl,2.2045199999999996
+157059,Modify the molecule C[C@H]1CCC[C@@]2(CC[NH2+]C[C@@H]2c2ccccc2F)C1 to have a higher LogP value.,C[C@H]1CCC[C@@]2(CC[NH2+]C[C@@H]2c2ccccc2F)C1,3.0729000000000015
+222856,Modify the molecule COc1ccc(CCCC(=O)N2CCc3nn(C)c(=O)cc3C2)cc1F to have a higher LogP value.,COc1ccc(CCCC(=O)N2CCc3nn(C)c(=O)cc3C2)cc1F,1.8356
+244933,Modify the molecule N#Cc1ccc(NC(=O)N2CCNC(=O)C[C@H]2c2ccccc2)cc1 to have a lower LogP value.,N#Cc1ccc(NC(=O)N2CCNC(=O)C[C@H]2c2ccccc2)cc1,2.653380000000001
+51465,Please modify the molecule COC(=O)C1=C(C)N=C2S[C@H](C)C(=O)N2[C@H]1c1ccc(C)cc1 to increase its LogP value.,COC(=O)C1=C(C)N=C2S[C@H](C)C(=O)N2[C@H]1c1ccc(C)cc1,2.8166200000000012
+59674,Please modify the molecule Cc1ccc(-n2nnc(C(=O)N3CCC[NH+](C(C)C)CC3)c2C)cc1 to increase its LogP value.,Cc1ccc(-n2nnc(C(=O)N3CCC[NH+](C(C)C)CC3)c2C)cc1,1.0233400000000004
+27061,Please modify the molecule CC(C)N1CCO[C@H](C(=O)CC2CCOCC2)C1 to decrease its LogP value.,CC(C)N1CCO[C@H](C(=O)CC2CCOCC2)C1,1.4813999999999996
+131848,Optimize the molecule Cc1ccccc1NC(=O)C1CCN(S(=O)(=O)c2ccccc2)CC1 to have a higher LogP value.,Cc1ccccc1NC(=O)C1CCN(S(=O)(=O)c2ccccc2)CC1,3.0344200000000017
+196937,Please optimize the molecule CCN1CC(=O)N(CCCCC(=O)NN)CC1=O to have a higher LogP value.,CCN1CC(=O)N(CCCCC(=O)NN)CC1=O,-1.1626999999999978
+18840,Please optimize the molecule C[C@H]1CC[C@H](CCC(=O)Nc2c(F)cccc2F)O1 to have a higher LogP value.,C[C@H]1CC[C@H](CCC(=O)Nc2c(F)cccc2F)O1,3.2510000000000012
+2681,Please optimize the molecule COc1ccc([N+](=O)[O-])cc1S(=O)(=O)NC1CCCCCCC1 to have a lower LogP value.,COc1ccc([N+](=O)[O-])cc1S(=O)(=O)NC1CCCCCCC1,2.994600000000002
+168925,Please modify the molecule COc1c(Cl)cc(Cl)cc1/C=C(\C#N)c1nn(CCO)c(N)c1C#N to decrease its LogP value.,COc1c(Cl)cc(Cl)cc1/C=C(\C#N)c1nn(CCO)c(N)c1C#N,2.708860000000001
+70362,Optimize the molecule C#CCNCC(=O)N[C@@H](C)c1cnn(C)c1C to have a higher LogP value.,C#CCNCC(=O)N[C@@H](C)c1cnn(C)c1C,0.12851999999999952
+145848,Please optimize the molecule CCOc1ccc(NC(=O)[C@@H]2Cc3ccccc3CN2C(C)=O)cc1OC to have a higher LogP value.,CCOc1ccc(NC(=O)[C@@H]2Cc3ccccc3CN2C(C)=O)cc1OC,3.0058000000000016
+200857,Please modify the molecule OCCCn1c(SCc2ccccc2Cl)nnc1-c1cccnc1 to increase its LogP value.,OCCCn1c(SCc2ccccc2Cl)nnc1-c1cccnc1,3.6682000000000023
+43342,Modify the molecule O=C(COC(=O)c1cc2ccccc2oc1=O)NC1CCCCC1 to have a higher LogP value.,O=C(COC(=O)c1cc2ccccc2oc1=O)NC1CCCCC1,2.3987000000000007
+78338,Modify the molecule COc1ccccc1C[C@H](O)C(C)(C)[NH+]1CCCCCC1 to have a higher LogP value.,COc1ccccc1C[C@H](O)C(C)(C)[NH+]1CCCCCC1,1.8360999999999996
+101204,Optimize the molecule N#CCCNS(=O)(=O)c1ccc(C(=O)NCC(F)(F)F)cc1 to have a higher LogP value.,N#CCCNS(=O)(=O)c1ccc(C(=O)NCC(F)(F)F)cc1,1.17068
+22,Please optimize the molecule O=C(NCCNC(=O)N1C[C@H]2CC=CC[C@@H]2C1)c1cccnc1 to have a higher LogP value.,O=C(NCCNC(=O)N1C[C@H]2CC=CC[C@@H]2C1)c1cccnc1,1.4189999999999996
+104611,Optimize the molecule CCOC[C@@H](O)CN1CCN(c2ccc(CC)cc2)CC1 to have a higher LogP value.,CCOC[C@@H](O)CN1CCN(c2ccc(CC)cc2)CC1,1.7683999999999997
+221182,Modify the molecule C#CCOc1ccc(C[NH2+][C@@H](C)c2ccccc2)cc1 to decrease its LogP value.,C#CCOc1ccc(C[NH2+][C@@H](C)c2ccccc2)cc1,2.523200000000001
+236189,Modify the molecule CCC(=O)N[C@@H](CCSC)C(=O)Nc1ccc(C)cc1 to decrease its LogP value.,CCC(=O)N[C@@H](CCSC)C(=O)Nc1ccc(C)cc1,2.5814200000000005
+58046,Please modify the molecule Cc1cc(C)c(S(=O)(=O)Nc2ccc(N3CC[NH2+]CC3)c(C(=O)N3CCOCC3)c2)c(C)c1 to decrease its LogP value.,Cc1cc(C)c(S(=O)(=O)Nc2ccc(N3CC[NH2+]CC3)c(C(=O)N3CCOCC3)c2)c(C)c1,1.2684600000000021
+156472,Please optimize the molecule CC(C)[C@@H](NC(=O)c1cnsn1)c1cccs1 to have a lower LogP value.,CC(C)[C@@H](NC(=O)c1cnsn1)c1cccs1,2.726700000000001
+110571,Please optimize the molecule CC[C@@H](C)NS(=O)(=O)c1ccc(C(=O)Nc2ccc(-n3cnc4ccccc43)cc2)cc1 to have a higher LogP value.,CC[C@@H](C)NS(=O)(=O)c1ccc(C(=O)Nc2ccc(-n3cnc4ccccc43)cc2)cc1,4.354600000000003
+29131,Please optimize the molecule N/C(NCCc1csc(-c2ccccc2)n1)=[NH+]\C[C@@H]1CCCO1 to have a higher LogP value.,N/C(NCCc1csc(-c2ccccc2)n1)=[NH+]\C[C@@H]1CCCO1,0.5165
+232917,Modify the molecule CC(C)[C@@H](CNC(=O)N1CCN(c2nccs2)CC1)[NH+]1CCCCCC1 to have a lower LogP value.,CC(C)[C@@H](CNC(=O)N1CCN(c2nccs2)CC1)[NH+]1CCCCCC1,1.4582000000000013
+229531,Please modify the molecule Cc1noc2nc(-c3cnn(C)c3)cc(C(=O)NCCCn3nccc3C3CC3)c12 to increase its LogP value.,Cc1noc2nc(-c3cnn(C)c3)cc(C(=O)NCCCn3nccc3C3CC3)c12,2.8257200000000013
+187443,Please modify the molecule CCCOc1cccc(/C=c2\s/c(=C\C(=O)c3ccco3)[nH]c2=O)c1 to increase its LogP value.,CCCOc1cccc(/C=c2\s/c(=C\C(=O)c3ccco3)[nH]c2=O)c1,2.3104000000000005
+1810,Please optimize the molecule C[C@@H](N[C@H]1CCc2c(Cl)cc(Cl)cc21)c1nnc2ccccn12 to have a higher LogP value.,C[C@@H](N[C@H]1CCc2c(Cl)cc(Cl)cc21)c1nnc2ccccn12,4.374200000000004
+125311,Modify the molecule Cc1cc(S(=O)(=O)N[C@H](c2nccs2)C2CC2)c(F)cc1F to decrease its LogP value.,Cc1cc(S(=O)(=O)N[C@H](c2nccs2)C2CC2)c(F)cc1F,3.159320000000002
+132058,Please optimize the molecule O=[N+]([O-])c1ccc(C(F)(F)F)nc1Cl to have a lower LogP value.,O=[N+]([O-])c1ccc(C(F)(F)F)nc1Cl,2.662000000000001
+13524,Optimize the molecule COC(=O)c1ncccc1N[C@@H]1CCO[C@H]1c1ccc(Cl)cc1 to have a lower LogP value.,COC(=O)c1ncccc1N[C@@H]1CCO[C@H]1c1ccc(Cl)cc1,3.463700000000002
+112989,Optimize the molecule COC(=O)CC(=O)c1cc(Cl)cc(Cl)c1 to have a higher LogP value.,COC(=O)CC(=O)c1cc(Cl)cc(Cl)c1,2.739200000000001
+47409,Optimize the molecule CCc1nc([C@@H]2CCCN2Cc2ccc(C#N)cc2F)no1 to have a lower LogP value.,CCc1nc([C@@H]2CCCN2Cc2ccc(C#N)cc2F)no1,2.9798800000000014
+241398,Modify the molecule CCOc1ccc(C2=N[C@@H](c3cccc(F)c3)[NH2+][C@H](c3cccc(OCC)c3O)C2)cc1 to increase its LogP value.,CCOc1ccc(C2=N[C@@H](c3cccc(F)c3)[NH2+][C@H](c3cccc(OCC)c3O)C2)cc1,4.525000000000004
+23222,Modify the molecule C[NH+](C)[C@H]1CCN(c2nc3ccc(Cl)cc3s2)C[C@H]1CCCO to decrease its LogP value.,C[NH+](C)[C@H]1CCN(c2nc3ccc(Cl)cc3s2)C[C@H]1CCCO,2.0616000000000008
+245866,Modify the molecule O=C(CCn1c(=O)oc2ccccc21)NN1C(=O)NC(c2ccccc2)(c2ccccc2)C1=O to have a lower LogP value.,O=C(CCn1c(=O)oc2ccccc21)NN1C(=O)NC(c2ccccc2)(c2ccccc2)C1=O,2.5114
+32643,Modify the molecule CCN(Cc1ccc(OC)c(OC)c1)C(=O)c1oc(C)nc1C to have a higher LogP value.,CCN(Cc1ccc(OC)c(OC)c1)C(=O)c1oc(C)nc1C,2.9709400000000015
+216665,Please modify the molecule CCOc1cc2[nH]c(=S)n([C@@H](C)CC)c(=O)c2cc1OCC to decrease its LogP value.,CCOc1cc2[nH]c(=S)n([C@@H](C)CC)c(=O)c2cc1OCC,3.8274900000000027
+160588,Please modify the molecule O=C(CCN1C(=O)[C@H]2CC=CC[C@H]2C1=O)NC1CCCCCC1 to decrease its LogP value.,O=C(CCN1C(=O)[C@H]2CC=CC[C@H]2C1=O)NC1CCCCCC1,2.1666999999999996
+15165,Modify the molecule Cc1ccc(C[NH2+]CCCN2CCCCCC2=O)s1 to decrease its LogP value.,Cc1ccc(C[NH2+]CCCN2CCCCCC2=O)s1,1.9126199999999998
+230238,Modify the molecule CN(C)c1cnn(CCC[NH+]2CCN(c3cccc(Cl)c3)CC2)c(=O)c1 to increase its LogP value.,CN(C)c1cnn(CCC[NH+]2CCN(c3cccc(Cl)c3)CC2)c(=O)c1,0.7579000000000009
+204346,Please modify the molecule CCOC(=O)C1(C(=O)Nc2cnc(-c3ccccc3)s2)CC1 to decrease its LogP value.,CCOC(=O)C1(C(=O)Nc2cnc(-c3ccccc3)s2)CC1,3.0919000000000016
+191649,Optimize the molecule CCOC(=O)c1cc(-c2cccs2)nc2c1c(C)nn2-c1cccc(C)c1 to have a higher LogP value.,CCOC(=O)c1cc(-c2cccs2)nc2c1c(C)nn2-c1cccc(C)c1,4.942540000000005
+134524,Please modify the molecule NC(=O)C1([NH2+]Cc2nnc(Cc3ccccc3)o2)CCCCC1 to decrease its LogP value.,NC(=O)C1([NH2+]Cc2nnc(Cc3ccccc3)o2)CCCCC1,0.9120000000000001
+66125,Please optimize the molecule CC[C@@]1(c2ccc(NC(=O)c3nc(-c4ccco4)sc3C)cc2)CCC(=O)NC1=O to have a higher LogP value.,CC[C@@]1(c2ccc(NC(=O)c3nc(-c4ccco4)sc3C)cc2)CCC(=O)NC1=O,4.048220000000002
+152959,Modify the molecule COc1cccc(Nc2ncnc(-n3cnc4ccccc43)c2[N+](=O)[O-])c1 to decrease its LogP value.,COc1cccc(Nc2ncnc(-n3cnc4ccccc43)c2[N+](=O)[O-])c1,3.475900000000002
+194866,Modify the molecule Nc1nc(Cl)c2ncn([C@@H]3O[C@H](CO)[C@H](O)[C@@H]3O)c2n1 to increase its LogP value.,Nc1nc(Cl)c2ncn([C@@H]3O[C@H](CO)[C@H](O)[C@@H]3O)c2n1,-1.3266000000000007
+190364,Please optimize the molecule CCS[C@H]1CCCC[C@H]1NC(=O)N[C@@H]1CCN(C(C)C)C1=O to have a lower LogP value.,CCS[C@H]1CCCC[C@H]1NC(=O)N[C@@H]1CCN(C(C)C)C1=O,2.3592000000000004
+25970,Modify the molecule O=C(CCc1ccsc1)N1Cc2ccccc2[C@H](c2ccccc2)C1 to have a higher LogP value.,O=C(CCc1ccsc1)N1Cc2ccccc2[C@H](c2ccccc2)C1,4.855000000000005
+207146,Modify the molecule C/C(CC(=O)Nc1ccc(F)cc1F)=N\NC(=O)c1ccc(O)cc1 to decrease its LogP value.,C/C(CC(=O)Nc1ccc(F)cc1F)=N\NC(=O)c1ccc(O)cc1,2.804900000000001
+11694,Optimize the molecule COC(=O)c1cc(C[NH+]2[C@@H](C)CC[C@@H]2C)c[nH]1 to have a higher LogP value.,COC(=O)c1cc(C[NH+]2[C@@H](C)CC[C@@H]2C)c[nH]1,0.7569999999999999
+146946,Optimize the molecule C[C@@H](NC(=O)COc1cc(F)ccc1F)c1cccc(NC(=O)c2ccccc2)c1 to have a higher LogP value.,C[C@@H](NC(=O)COc1cc(F)ccc1F)c1cccc(NC(=O)c2ccccc2)c1,4.473300000000003
+233083,Modify the molecule Cc1cccn2c(=O)c(C(=O)N3CC[C@H](c4ccccc4)[C@H]3C)cnc12 to have a higher LogP value.,Cc1cccn2c(=O)c(C(=O)N3CC[C@H](c4ccccc4)[C@H]3C)cnc12,3.0211200000000016
+138275,Please modify the molecule CC(=O)NC(=S)Nc1ccc(C(=O)NC(C)(C)C)cc1 to increase its LogP value.,CC(=O)NC(=S)Nc1ccc(C(=O)NC(C)(C)C)cc1,2.0478
+67658,Optimize the molecule C[NH+](Cc1ccc(C(=O)NC2CC2)cc1)Cc1cc2c(cc1Br)OCCO2 to have a lower LogP value.,C[NH+](Cc1ccc(C(=O)NC2CC2)cc1)Cc1cc2c(cc1Br)OCCO2,2.327400000000001
+57506,Optimize the molecule C[C@H]1CCC[C@H](OCc2cccc(NC(=O)[C@H](C)[NH+](C)C)c2)C1 to have a higher LogP value.,C[C@H]1CCC[C@H](OCc2cccc(NC(=O)[C@H](C)[NH+](C)C)c2)C1,2.2534
+88667,Please optimize the molecule Cc1cccc(N/C([O-])=C(\C#N)C(=O)Cn2nc3n(c2=O)CCCCC3)c1 to have a lower LogP value.,Cc1cccc(N/C([O-])=C(\C#N)C(=O)Cn2nc3n(c2=O)CCCCC3)c1,0.8562999999999992
+22960,Please modify the molecule CC(C)C[NH+]1CC[C@H](N2CCOCC2)C[C@H]1C to increase its LogP value.,CC(C)C[NH+]1CC[C@H](N2CCOCC2)C[C@H]1C,0.4104000000000012
+61439,Please optimize the molecule CC(C)(O)CC[NH+]1CCN(c2ccc(F)cc2)CC1 to have a lower LogP value.,CC(C)(O)CC[NH+]1CCN(c2ccc(F)cc2)CC1,0.6916000000000002
+46267,Please modify the molecule C[NH+](CC(=O)NC1(C#N)CCCCCC1)[C@@H]1CCCc2ccccc21 to increase its LogP value.,C[NH+](CC(=O)NC1(C#N)CCCCCC1)[C@@H]1CCCc2ccccc21,2.3114799999999995
+110439,Modify the molecule CC[C@H]1CCCN(C(=O)NCc2ccccc2C)C1 to increase its LogP value.,CC[C@H]1CCCN(C(=O)NCc2ccccc2C)C1,3.326620000000002
+186566,Modify the molecule COc1ccc([C@@H]2CCCN2C(=O)Nc2ccc3oc(C4CC4)nc3c2)c(OC)c1 to have a higher LogP value.,COc1ccc([C@@H]2CCCN2C(=O)Nc2ccc3oc(C4CC4)nc3c2)c(OC)c1,5.091400000000005
+214340,Optimize the molecule Fc1cc(CNc2ncnc3[nH]cnc23)ccc1Oc1cccnc1 to have a higher LogP value.,Fc1cc(CNc2ncnc3[nH]cnc23)ccc1Oc1cccnc1,3.291400000000001
+89051,Please modify the molecule O=C(CC1=c2ccccc2=[NH+]C1)OCC(=O)N1CCc2ccccc21 to increase its LogP value.,O=C(CC1=c2ccccc2=[NH+]C1)OCC(=O)N1CCc2ccccc21,-0.926299999999997
+5532,Optimize the molecule C[NH2+]Cc1ccc(OCc2c[nH+]cn2C)c(Cl)c1 to have a lower LogP value.,C[NH2+]Cc1ccc(OCc2c[nH+]cn2C)c(Cl)c1,0.7647999999999995
+210001,Modify the molecule NC(=O)c1ccc(NCc2cc(Cl)cs2)cc1Cl to have a higher LogP value.,NC(=O)c1ccc(NCc2cc(Cl)cs2)cc1Cl,3.765900000000001
+10717,Optimize the molecule COc1ccccc1NC(=O)c1sc2ncn(C[C@@H](O)CO)c(=O)c2c1C to have a lower LogP value.,COc1ccccc1NC(=O)c1sc2ncn(C[C@@H](O)CO)c(=O)c2c1C,1.3805199999999997
+16263,Optimize the molecule CN(C[C@H]1CCCCO1)C(=O)c1cc2ccccc2c(=O)[nH]1 to have a lower LogP value.,CN(C[C@H]1CCCCO1)C(=O)c1cc2ccccc2c(=O)[nH]1,2.1692
+244247,Modify the molecule CC(C)n1nc(C[NH2+]CCCO)c(-c2ccccc2)n1 to decrease its LogP value.,CC(C)n1nc(C[NH2+]CCCO)c(-c2ccccc2)n1,0.9717999999999996
+16580,Modify the molecule CCC(=O)N(C)c1ccccc1C(=O)Nc1ccc2c(c1)OCCO2 to increase its LogP value.,CCC(=O)N(C)c1ccccc1C(=O)Nc1ccc2c(c1)OCCO2,3.0829000000000013
+119786,Modify the molecule CN(C)c1ccc(/C=N/N2C(=O)[C@@H]3[C@@H](C2=O)[C@H]2C=C[C@@H]3C23CC3)cc1Br to have a higher LogP value.,CN(C)c1ccc(/C=N/N2C(=O)[C@@H]3[C@@H](C2=O)[C@H]2C=C[C@@H]3C23CC3)cc1Br,3.0462000000000016
+198554,Modify the molecule CC[C@@](C)([NH2+]CC(=O)N[C@@H](C)C(C)C)C(=O)[O-] to have a higher LogP value.,CC[C@@](C)([NH2+]CC(=O)N[C@@H](C)C(C)C)C(=O)[O-],-1.3708999999999976
+151999,Please optimize the molecule COc1ncccc1C(=O)OCc1nnc(-c2ccccc2)n1C to have a higher LogP value.,COc1ncccc1C(=O)OCc1nnc(-c2ccccc2)n1C,2.2427
+190438,Please modify the molecule CC(=O)Nc1cc(NC(=O)C(C)(C)F)ccc1F to increase its LogP value.,CC(=O)Nc1cc(NC(=O)C(C)(C)F)ccc1F,2.4707
+175353,Modify the molecule C=C(C)[C@@H]1CC=C(CN2C[C@H](NC(=O)c3cc(C)nc4ccccc34)C[C@H]2C(=O)OC)CC1 to increase its LogP value.,C=C(C)[C@@H]1CC=C(CN2C[C@H](NC(=O)c3cc(C)nc4ccccc34)C[C@H]2C(=O)OC)CC1,4.191520000000003
+77561,Modify the molecule CN(Cc1nc2c(F)cccc2[nH]1)[C@@H]1CCSC1 to increase its LogP value.,CN(Cc1nc2c(F)cccc2[nH]1)[C@@H]1CCSC1,2.6393000000000004
+117432,Modify the molecule C=CC[C@@H]1CC=C[C@@H](c2ccccc2)N1C(=O)CCc1c(C)nn(C)c1C to have a higher LogP value.,C=CC[C@@H]1CC=C[C@@H](c2ccccc2)N1C(=O)CCc1c(C)nn(C)c1C,4.444040000000004
+214022,Please modify the molecule CC(=O)Nc1ccc(OC(=O)[C@H](NC(=O)c2cccs2)C(C)C)cc1 to decrease its LogP value.,CC(=O)Nc1ccc(OC(=O)[C@H](NC(=O)c2cccs2)C(C)C)cc1,3.0665000000000013
+16255,Modify the molecule COc1ccc(/C=C\C(=O)N2CCN(c3nccn3-c3ccc(C)cc3)CC2)cc1OC to have a lower LogP value.,COc1ccc(/C=C\C(=O)N2CCN(c3nccn3-c3ccc(C)cc3)CC2)cc1OC,3.5599200000000026
+82853,Modify the molecule Cn1c(-c2nnc(SCC(=O)Nc3cccc(F)c3)o2)cc2ccccc21 to increase its LogP value.,Cn1c(-c2nnc(SCC(=O)Nc3cccc(F)c3)o2)cc2ccccc21,4.098200000000002
+104576,Please optimize the molecule CC1(C)Cc2cc([C@@H]3NC(=O)[C@@H]4CCCCN43)ccc2O1 to have a higher LogP value.,CC1(C)Cc2cc([C@@H]3NC(=O)[C@@H]4CCCCN43)ccc2O1,2.383
+248398,Modify the molecule Cc1ccc2c(Nc3ccc(C)c(C)c3)c(C(=O)N3CCCC[C@@H]3C)cnc2n1 to have a lower LogP value.,Cc1ccc2c(Nc3ccc(C)c(C)c3)c(C(=O)N3CCCC[C@@H]3C)cnc2n1,5.313260000000005
+107722,Optimize the molecule S=C(NCc1ccco1)Nc1ccc(Nc2ccccc2)cc1 to have a higher LogP value.,S=C(NCc1ccco1)Nc1ccc(Nc2ccccc2)cc1,4.509800000000002
+216348,Optimize the molecule Cc1nn(C)cc1C[NH+]1CCCCC[C@@H]1c1cccc(F)c1 to have a lower LogP value.,Cc1nn(C)cc1C[NH+]1CCCCC[C@@H]1c1cccc(F)c1,2.56782
+224406,Optimize the molecule CC[C@@H](CNC(=O)N[C@@H]1CCC[C@@H]1C(N)=O)c1ccccc1 to have a lower LogP value.,CC[C@@H](CNC(=O)N[C@@H]1CCC[C@@H]1C(N)=O)c1ccccc1,2.133399999999999
+182209,Modify the molecule O=C(COc1cccc(-c2nnco2)c1)N(C1CCCC1)C1CC1 to increase its LogP value.,O=C(COc1cccc(-c2nnco2)c1)N(C1CCCC1)C1CC1,3.0490000000000013
+198116,Modify the molecule C/[NH+]=C(/NC[C@H](C)C#N)NC[C@@H]1CCC[NH+](C)C1 to have a higher LogP value.,C/[NH+]=C(/NC[C@H](C)C#N)NC[C@@H]1CCC[NH+](C)C1,-2.683619999999995
+174823,Please modify the molecule COc1ccc2c(c1)c(=O)c(S(=O)(=O)c1ccc(F)cc1)cn2CC(=O)Nc1cc(C)ccc1C to increase its LogP value.,COc1ccc2c(c1)c(=O)c(S(=O)(=O)c1ccc(F)cc1)cn2CC(=O)Nc1cc(C)ccc1C,4.237540000000003
+95154,Modify the molecule CCN(C1CC[NH+](Cc2ccc(F)c(C(F)(F)F)c2)CC1)S(C)(=O)=O to have a lower LogP value.,CCN(C1CC[NH+](Cc2ccc(F)c(C(F)(F)F)c2)CC1)S(C)(=O)=O,1.6733000000000005
+71370,Please modify the molecule COc1cc(C2=Nn3c(nnc3-c3ccc4ccccc4c3)SC2)cc(OC)c1OC to increase its LogP value.,COc1cc(C2=Nn3c(nnc3-c3ccc4ccccc4c3)SC2)cc(OC)c1OC,4.482200000000004
+84116,Please optimize the molecule CC(CO)(CO)NC(=O)CN1CCN(c2ccc(F)cc2)C1=O to have a higher LogP value.,CC(CO)(CO)NC(=O)CN1CCN(c2ccc(F)cc2)C1=O,-0.07279999999999998
+150676,Please modify the molecule CCOc1ccc(C2(CNC(=O)c3ccc(Br)cc3F)CCOCC2)cc1 to increase its LogP value.,CCOc1ccc(C2(CNC(=O)c3ccc(Br)cc3F)CCOCC2)cc1,4.465100000000003
+120006,Please modify the molecule O=C(C[C@H](O)c1cccc(F)c1)N1CCC[C@H]1c1cccc2c1OCCO2 to decrease its LogP value.,O=C(C[C@H](O)c1cccc(F)c1)N1CCC[C@H]1c1cccc2c1OCCO2,3.384100000000002
+25013,Please modify the molecule Cc1ccc2c(CC(=O)N3CCN(S(=O)(=O)/C=C/c4ccccc4)CC3)coc2c1 to decrease its LogP value.,Cc1ccc2c(CC(=O)N3CCN(S(=O)(=O)/C=C/c4ccccc4)CC3)coc2c1,3.428620000000002
+204720,Please modify the molecule O=C(CN1C(=O)S/C(=C\c2ccncc2)C1=O)N1CCOCC1 to decrease its LogP value.,O=C(CN1C(=O)S/C(=C\c2ccncc2)C1=O)N1CCOCC1,0.9767000000000002
+156113,Modify the molecule CC(C)C[C@@H](O)C1CC[NH+](Cc2cc(F)cc(Cl)c2)CC1 to have a higher LogP value.,CC(C)C[C@@H](O)C1CC[NH+](Cc2cc(F)cc(Cl)c2)CC1,2.681000000000001
+6747,Modify the molecule C[C@H](C(=O)Nc1cnn(C)c1)N1CC2(CCOCC2)Oc2ccccc2C1=O to have a lower LogP value.,C[C@H](C(=O)Nc1cnn(C)c1)N1CC2(CCOCC2)Oc2ccccc2C1=O,1.831099999999999
+168148,Please optimize the molecule Cc1cccnc1CN1CCN(c2[nH+]ncc3ccccc23)CC1 to have a higher LogP value.,Cc1cccnc1CN1CCN(c2[nH+]ncc3ccccc23)CC1,2.0745199999999997
+99736,Optimize the molecule C[C@@H]1[NH2+]C2(CCCCC2)CO[C@@H]1C to have a lower LogP value.,C[C@@H]1[NH2+]C2(CCCCC2)CO[C@@H]1C,1.0598999999999994
+234079,Optimize the molecule O=C(c1ccc(NCc2ccccc2)nc1)N1CCCN(c2ncccn2)CC1 to have a lower LogP value.,O=C(c1ccc(NCc2ccccc2)nc1)N1CCCN(c2ncccn2)CC1,2.8362000000000007
+171188,Please modify the molecule Cc1cc(F)cc(C(=O)N2C[C@H](C(N)=O)CC[C@H]2C)c1 to increase its LogP value.,Cc1cc(F)cc(C(=O)N2C[C@H](C(N)=O)CC[C@H]2C)c1,1.8601199999999998
+133616,Please modify the molecule CCSC[C@@H](C)N(C)C(=O)CCn1cc(C)cn1 to increase its LogP value.,CCSC[C@@H](C)N(C)C(=O)CCn1cc(C)cn1,2.1816199999999997
+9220,Please optimize the molecule CC[NH+]1CCN(CCC(=O)N2CCO[C@H](c3ccc(F)cc3)C2)CC1 to have a higher LogP value.,CC[NH+]1CCN(CCC(=O)N2CCO[C@H](c3ccc(F)cc3)C2)CC1,0.33610000000000206
+63275,Modify the molecule Cc1ccc(C(=O)NC(Nc2c(C)n(C)n(-c3ccccc3)c2=O)(C(F)(F)F)C(F)(F)F)cc1 to decrease its LogP value.,Cc1ccc(C(=O)NC(Nc2c(C)n(C)n(-c3ccccc3)c2=O)(C(F)(F)F)C(F)(F)F)cc1,4.455640000000003
+21393,Please optimize the molecule Cc1cc([C@H](C)NS(=O)(=O)c2cc3c(cc2Cl)NC(=O)CO3)c(C)o1 to have a higher LogP value.,Cc1cc([C@H](C)NS(=O)(=O)c2cc3c(cc2Cl)NC(=O)CO3)c(C)o1,2.9202400000000006
+208992,Please modify the molecule C=Cc1ccc(Cn2nc3n(C)c(=O)c4ccc(C(=O)N[C@@H](C)CC)cc4n3c2=O)cc1 to increase its LogP value.,C=Cc1ccc(Cn2nc3n(C)c(=O)c4ccc(C(=O)N[C@@H](C)CC)cc4n3c2=O)cc1,2.567500000000001
+88072,Optimize the molecule Cc1ccncc1NC(=O)NCCn1cc[nH+]c1 to have a higher LogP value.,Cc1ccncc1NC(=O)NCCn1cc[nH+]c1,0.8273199999999998
+156483,Modify the molecule COCc1cc(C(=O)N(Cc2ccco2)C[C@@H]2CCCO2)no1 to have a higher LogP value.,COCc1cc(C(=O)N(Cc2ccco2)C[C@@H]2CCCO2)no1,2.2354000000000003
+56294,Modify the molecule Cc1ccc([C@H]2c3c(oc4cc(C)c(Cl)cc4c3=O)C(=O)N2CCN2CCOCC2)cc1 to have a higher LogP value.,Cc1ccc([C@H]2c3c(oc4cc(C)c(Cl)cc4c3=O)C(=O)N2CCN2CCOCC2)cc1,3.940640000000003
+122594,Modify the molecule Cc1ccc(S(=O)(=O)CCC(=O)Oc2ccc(Cl)cc2Cl)cc1 to increase its LogP value.,Cc1ccc(S(=O)(=O)CCC(=O)Oc2ccc(Cl)cc2Cl)cc1,4.071220000000003
+236967,Please modify the molecule Cc1cnc(C(C)(C)NC(=O)c2cccc(C(=O)OC(C)(C)C)c2)s1 to increase its LogP value.,Cc1cnc(C(C)(C)NC(=O)c2cccc(C(=O)OC(C)(C)C)c2)s1,4.071920000000003
+102886,Modify the molecule COc1cccc(OCC2CCN(C(=O)c3cnc4c(c3)NC(=O)CO4)CC2)c1 to have a lower LogP value.,COc1cccc(OCC2CCN(C(=O)c3cnc4c(c3)NC(=O)CO4)CC2)c1,2.3523000000000005
+179097,Modify the molecule O=C(c1c[nH]c2ncccc12)N1CCC[C@H]1Cn1cccn1 to increase its LogP value.,O=C(c1c[nH]c2ncccc12)N1CCC[C@H]1Cn1cccn1,2.0641999999999996
+220907,Please optimize the molecule Cc1cccc(C)c1NC(=O)N[C@H](C)c1ccc(-c2cncnc2)cc1 to have a lower LogP value.,Cc1cccc(C)c1NC(=O)N[C@H](C)c1ccc(-c2cncnc2)cc1,4.643140000000003
+70793,Please modify the molecule Cc1nonc1NC(=O)c1cccc(C(F)(F)F)c1 to increase its LogP value.,Cc1nonc1NC(=O)c1cccc(C(F)(F)F)c1,2.649120000000001
+113516,Modify the molecule CN(C)c1ncnc(NCc2ccc(Cl)cc2)c1[N+](=O)[O-] to decrease its LogP value.,CN(C)c1ncnc(NCc2ccc(Cl)cc2)c1[N+](=O)[O-],2.7163000000000013
+112069,Please optimize the molecule Cc1cc(C)c(N(C=O)C(=O)[C@H]2[C@H](C)[C@@H]3C=C[C@H]2C32CC2)c(C)c1 to have a lower LogP value.,Cc1cc(C)c(N(C=O)C(=O)[C@H]2[C@H](C)[C@@H]3C=C[C@H]2C32CC2)c(C)c1,3.9495600000000035
+155625,Modify the molecule Cc1ccccc1Cc1noc(C[NH+](C[C@H](C)O)C2CCCCC2)n1 to increase its LogP value.,Cc1ccccc1Cc1noc(C[NH+](C[C@H](C)O)C2CCCCC2)n1,2.06722
+246491,Optimize the molecule C=C(Cl)CN1C[C@@H](c2ccccc2C)OC[C@H]1C to have a lower LogP value.,C=C(Cl)CN1C[C@@H](c2ccccc2C)OC[C@H]1C,3.5093200000000024
+187615,Please optimize the molecule c1cc(-c2nc(C3CC3)no2)c2cc[nH]c2c1 to have a lower LogP value.,c1cc(-c2nc(C3CC3)no2)c2cc[nH]c2c1,3.095300000000001
+62238,Please optimize the molecule CCOc1ccc2c(c1)=[NH+][C@@H](SCC(=O)Nc1ccc(Cl)cn1)[NH+]=2 to have a lower LogP value.,CCOc1ccc2c(c1)=[NH+][C@@H](SCC(=O)Nc1ccc(Cl)cn1)[NH+]=2,-1.7967999999999966
+12501,Please modify the molecule Cc1ccc2ncc(CN3CCN(Cc4ccc(Cl)nc4)CC3)n2c1 to decrease its LogP value.,Cc1ccc2ncc(CN3CCN(Cc4ccc(Cl)nc4)CC3)n2c1,3.0089200000000016
+118757,Modify the molecule CCC[C@@H](C)[C@H]([NH2+]CC)[C@@H](C)c1ccncc1 to have a lower LogP value.,CCC[C@@H](C)[C@H]([NH2+]CC)[C@@H](C)c1ccncc1,2.573200000000001
+134729,Optimize the molecule O=C(c1ccc(N2CCCS2(=O)=O)cc1)N(CCCN1CCOCC1)c1ccccc1 to have a lower LogP value.,O=C(c1ccc(N2CCCS2(=O)=O)cc1)N(CCCN1CCOCC1)c1ccccc1,2.5956
+16706,Modify the molecule CC(C)Cn1cc(NC(=O)C[C@H](NC(N)=O)c2cccs2)cn1 to have a lower LogP value.,CC(C)Cn1cc(NC(=O)C[C@H](NC(N)=O)c2cccs2)cn1,2.3388
+41704,Modify the molecule COc1ccc(OC)c([C@@H]2CCCN2C(=O)CSc2nnnn2-c2ccc(O)cc2)c1 to have a lower LogP value.,COc1ccc(OC)c([C@@H]2CCCN2C(=O)CSc2nnnn2-c2ccc(O)cc2)c1,2.8409000000000013
+209043,Optimize the molecule CC(C)(C[NH2+][C@@H]1CCCC[C@H]1[C@@H]1CCC[NH2+]1)NS(C)(=O)=O to have a lower LogP value.,CC(C)(C[NH2+][C@@H]1CCCC[C@H]1[C@@H]1CCC[NH2+]1)NS(C)(=O)=O,-0.8377999999999945
+207312,Please optimize the molecule C#CCN1CCN(c2cccc(F)c2[N+](=O)[O-])CC1 to have a lower LogP value.,C#CCN1CCN(c2cccc(F)c2[N+](=O)[O-])CC1,1.4891
+69671,Modify the molecule C[C@H](c1nc2ccccc2s1)[NH+](C)CC(=O)Nc1ccc2c(c1)OCCCO2 to have a lower LogP value.,C[C@H](c1nc2ccccc2s1)[NH+](C)CC(=O)Nc1ccc2c(c1)OCCCO2,2.6720000000000006
+134486,Please modify the molecule CC(C)Oc1nnc(SCc2nc3ccccc3c(=O)[nH]2)s1 to decrease its LogP value.,CC(C)Oc1nnc(SCc2nc3ccccc3c(=O)[nH]2)s1,2.8541000000000007
+68337,Please modify the molecule CC(C)n1cc(NC(=O)Nc2cccnc2Cl)cn1 to increase its LogP value.,CC(C)n1cc(NC(=O)Nc2cccnc2Cl)cn1,3.1564000000000005
+224215,Please optimize the molecule O=S(=O)(CCN1CCN(c2ccccc2)CC1)c1ccccc1 to have a lower LogP value.,O=S(=O)(CCN1CCN(c2ccccc2)CC1)c1ccccc1,2.2824999999999998
+166401,Please optimize the molecule Cc1ccc(OCCC[C@@H]2CCCCN2C(=O)OC(C)(C)C)nc1 to have a higher LogP value.,Cc1ccc(OCCC[C@@H]2CCCCN2C(=O)OC(C)(C)C)nc1,4.338620000000004
+102463,Optimize the molecule CN(Cc1cccs1)C(=O)CSc1ccc2ccccc2n1 to have a higher LogP value.,CN(Cc1cccs1)C(=O)CSc1ccc2ccccc2n1,4.047000000000003
+8769,Modify the molecule COc1ccccc1[C@H]1CC(=O)N=C(SCC(=O)Nc2nccs2)[C@H]1C#N to decrease its LogP value.,COc1ccccc1[C@H]1CC(=O)N=C(SCC(=O)Nc2nccs2)[C@H]1C#N,3.075780000000001
+10427,Modify the molecule CC(C)[C@]1(O)CN(C(=O)CNC(N)=O)C[C@H]1C to have a higher LogP value.,CC(C)[C@]1(O)CN(C(=O)CNC(N)=O)C[C@H]1C,-0.4798999999999989
+61624,Please modify the molecule Cc1ncsc1CN(Cc1ccccc1)C(=O)C1=NNC(=O)CC1 to increase its LogP value.,Cc1ncsc1CN(Cc1ccccc1)C(=O)C1=NNC(=O)CC1,2.24632
+127483,Please modify the molecule COc1ccc(-c2nnn(CC(=O)Nc3cccc(Br)c3)n2)cc1OC to decrease its LogP value.,COc1ccc(-c2nnn(CC(=O)Nc3cccc(Br)c3)n2)cc1OC,2.7585000000000006
+246082,Please modify the molecule CCC(=O)Nc1cccc(NC(=O)N2CCC(CCc3ccccc3)CC2)c1 to increase its LogP value.,CCC(=O)Nc1cccc(NC(=O)N2CCC(CCc3ccccc3)CC2)c1,4.911800000000004
+161272,Modify the molecule Cc1c(F)cc(C(N)=O)cc1NC(=O)c1ncccc1C(F)(F)F to increase its LogP value.,Cc1c(F)cc(C(N)=O)cc1NC(=O)c1ncccc1C(F)(F)F,2.899120000000001
+172542,Please modify the molecule Cc1oc(C)c(C(=O)NCc2ccc(C[NH+]3CCCC3)cc2)c1C to decrease its LogP value.,Cc1oc(C)c(C(=O)NCc2ccc(C[NH+]3CCCC3)cc2)c1C,2.31356
+153302,Please modify the molecule C[C@H](Oc1cc(Cl)ccc1Cl)C(=O)NC[C@@H]1CCCO1 to increase its LogP value.,C[C@H](Oc1cc(Cl)ccc1Cl)C(=O)NC[C@@H]1CCCO1,3.055900000000001
+82491,Modify the molecule Cc1cc(Br)ccc1NS(=O)(=O)c1cccc(C#N)c1 to have a lower LogP value.,Cc1cc(Br)ccc1NS(=O)(=O)c1cccc(C#N)c1,3.4300000000000015
+90807,Please optimize the molecule CCc1ccc(O)c(NC(=O)[C@@H](C[NH3+])c2ccccc2)c1 to have a lower LogP value.,CCc1ccc(O)c(NC(=O)[C@@H](C[NH3+])c2ccccc2)c1,1.9187999999999996
+180198,Modify the molecule Cc1ccc(NC(=O)c2c(C)oc3ccc(O)c(C[NH+]4CCCCC4)c23)cc1 to increase its LogP value.,Cc1ccc(NC(=O)c2c(C)oc3ccc(O)c(C[NH+]4CCCCC4)c23)cc1,3.5763400000000027
+7797,Modify the molecule O=C(NC1CC[NH+](CC2(O)CCCCC2)CC1)c1nc2ccccc2s1 to increase its LogP value.,O=C(NC1CC[NH+](CC2(O)CCCCC2)CC1)c1nc2ccccc2s1,1.7686000000000002
+159851,Modify the molecule C#CCNC(=O)[C@@H]1CCO[C@H]1C to increase its LogP value.,C#CCNC(=O)[C@@H]1CCO[C@H]1C,0.16080000000000005
+23835,Please optimize the molecule Cc1cc(NC(=O)c2cc(Cl)c[nH]2)n(Cc2ccccn2)n1 to have a higher LogP value.,Cc1cc(NC(=O)c2cc(Cl)c[nH]2)n(Cc2ccccn2)n1,2.86862
+206791,Please modify the molecule CC(=O)c1cccc(NCC(=O)N2CCCc3ccccc32)c1 to increase its LogP value.,CC(=O)c1cccc(NCC(=O)N2CCCc3ccccc32)c1,3.2805000000000017
+140949,Please optimize the molecule CC1(C)CCC[C@@H]1NC(=O)NC[C@@H](O)C1CCCC1 to have a lower LogP value.,CC1(C)CCC[C@@H]1NC(=O)NC[C@@H](O)C1CCCC1,2.4154
+108079,Please optimize the molecule Cc1ccc2oc(=O)n(CC(=O)N3CCC[C@@]4(CCOC4)C3)c2c1 to have a lower LogP value.,Cc1ccc2oc(=O)n(CC(=O)N3CCC[C@@]4(CCOC4)C3)c2c1,1.9320199999999998
+29013,Modify the molecule CCNC(=O)Cc1cc(-c2ccc(C)cc2)on1 to have a lower LogP value.,CCNC(=O)Cc1cc(-c2ccc(C)cc2)on1,2.32862
+32765,Please modify the molecule Cc1noc(C)c1[C@@H](C)NC(=O)CCOc1ccc2ccccc2c1 to decrease its LogP value.,Cc1noc(C)c1[C@@H](C)NC(=O)CCOc1ccc2ccccc2c1,4.090940000000003
+199318,Modify the molecule Cc1n[nH]c(C)c1C[C@H](C)C(=O)Nc1ccc(CN2CCOCC2)cc1 to have a higher LogP value.,Cc1n[nH]c(C)c1C[C@H](C)C(=O)Nc1ccc(CN2CCOCC2)cc1,2.6760400000000004
+19323,Optimize the molecule O=C(Cn1cnc2cc(F)ccc2c1=O)NCc1ccco1 to have a higher LogP value.,O=C(Cn1cnc2cc(F)ccc2c1=O)NCc1ccco1,1.445
+189179,Please modify the molecule O=C(N[C@]1(C(=O)[O-])CCSC1)c1nnn[n-]1 to decrease its LogP value.,O=C(N[C@]1(C(=O)[O-])CCSC1)c1nnn[n-]1,-2.8157999999999994
+35737,Please optimize the molecule Cc1ccc(-c2nnc(S[C@@H](C)C(=O)Nc3nc(-c4ccccc4)cs3)n2N)cc1 to have a higher LogP value.,Cc1ccc(-c2nnc(S[C@@H](C)C(=O)Nc3nc(-c4ccccc4)cs3)n2N)cc1,4.210120000000002
+176270,Modify the molecule CN(Cc1ccc(Cl)c(Cl)c1)C(=O)COc1ccc(-c2nnco2)cc1 to have a higher LogP value.,CN(Cc1ccc(Cl)c(Cl)c1)C(=O)COc1ccc(-c2nnco2)cc1,4.080800000000003
+66081,Please modify the molecule Cc1ccc([C@@H](N)c2cc(Br)ccc2Cl)s1 to increase its LogP value.,Cc1ccc([C@@H](N)c2cc(Br)ccc2Cl)s1,4.520520000000001
+63607,Modify the molecule O=C(c1cnccn1)N1CC[C@H](n2cnnc2-c2ccccc2)C1 to have a higher LogP value.,O=C(c1cnccn1)N1CC[C@H](n2cnnc2-c2ccccc2)C1,1.8223
+52074,Please modify the molecule Cc1nc2c(c(C)c1CCC(=O)N1CCCSCC1)c(=O)[nH]n2C to decrease its LogP value.,Cc1nc2c(c(C)c1CCC(=O)N1CCCSCC1)c(=O)[nH]n2C,1.7765399999999998
+4248,Please modify the molecule CC(C)(C)Sc1ccc(NC(=O)NCC2(O)CCCCCC2)cc1 to decrease its LogP value.,CC(C)(C)Sc1ccc(NC(=O)NCC2(O)CCCCCC2)cc1,4.784000000000003
+101152,Modify the molecule COc1ccc([C@@H]2OCC[C@H]2C[NH2+]C(C)C)cc1F to have a lower LogP value.,COc1ccc([C@@H]2OCC[C@H]2C[NH2+]C(C)C)cc1F,1.8837
+140857,Optimize the molecule C[NH+](C)CC(C)(C)CNS(=O)(=O)C[C@@]12CC[C@@H](CC1=O)C2(C)C to have a higher LogP value.,C[NH+](C)CC(C)(C)CNS(=O)(=O)C[C@@]12CC[C@@H](CC1=O)C2(C)C,0.47190000000000265
+238191,Optimize the molecule CCCN(CC#N)Cc1csc2ccccc12 to have a lower LogP value.,CCCN(CC#N)Cc1csc2ccccc12,3.6368800000000023
+158888,Modify the molecule CC(C)(C)C(=O)Nc1ccc(NC(=O)c2ccccc2O)cc1 to decrease its LogP value.,CC(C)(C)C(=O)Nc1ccc(NC(=O)c2ccccc2O)cc1,3.629100000000001
+246756,Optimize the molecule CC1=C[C@H]2C(=O)NC(CSCC(=O)Nc3ncc(C)s3)=N[C@H]2S1 to have a lower LogP value.,CC1=C[C@H]2C(=O)NC(CSCC(=O)Nc3ncc(C)s3)=N[C@H]2S1,2.24442
+87859,Optimize the molecule CN[C@]1(C#N)CC[C@H](SCCS(C)(=O)=O)C1 to have a lower LogP value.,CN[C@]1(C#N)CC[C@H](SCCS(C)(=O)=O)C1,0.7984799999999999
+242949,Please modify the molecule Cc1ccc(CN(C(=O)Nc2ccccc2)[C@H]2CCS(=O)(=O)C2)cc1 to increase its LogP value.,Cc1ccc(CN(C(=O)Nc2ccccc2)[C@H]2CCS(=O)(=O)C2)cc1,3.2162200000000016
+11870,Modify the molecule CCn1c(SCC(=O)N[C@H]2CCC[C@@H](C)[C@@H]2C)nc2sc(C)c(C)c2c1=O to decrease its LogP value.,CCn1c(SCC(=O)N[C@H]2CCC[C@@H](C)[C@@H]2C)nc2sc(C)c(C)c2c1=O,4.127740000000004
+173729,Modify the molecule CCOc1cc(NCc2cn[nH]c2N)ccc1[N+](=O)[O-] to increase its LogP value.,CCOc1cc(NCc2cn[nH]c2N)ccc1[N+](=O)[O-],1.9108999999999998
+119331,Please optimize the molecule C[C@H](NC(=O)N[C@](C)(C(=O)[O-])C(F)(F)F)C(N)=O to have a lower LogP value.,C[C@H](NC(=O)N[C@](C)(C(=O)[O-])C(F)(F)F)C(N)=O,-1.7696999999999994
+239035,Modify the molecule CC(C)Cn1c(S[C@@H](C)C(=O)N(C)C)nc2sc3c(c2c1=O)CC[C@H](C)C3 to increase its LogP value.,CC(C)Cn1c(S[C@@H](C)C(=O)N(C)C)nc2sc3c(c2c1=O)CC[C@H](C)C3,3.8076000000000025
+32994,Modify the molecule CCOc1cccc([C@H]2NC(=O)[C@@H]3COCCN32)c1OC(F)F to have a lower LogP value.,CCOc1cccc([C@H]2NC(=O)[C@@H]3COCCN32)c1OC(F)F,1.5158999999999998
+212697,Please modify the molecule COc1ccc(NC(=O)c2cccc(CN3CCCC3=O)c2)cn1 to increase its LogP value.,COc1ccc(NC(=O)c2cccc(CN3CCCC3=O)c2)cn1,2.4649
+235673,Modify the molecule C[C@@H](C#N)[C@@](C)(O)c1cccc(Cl)c1 to have a lower LogP value.,C[C@@H](C#N)[C@@](C)(O)c1cccc(Cl)c1,2.707180000000001
+199113,Optimize the molecule COCCOc1ccccc1CNc1cc(C)ccc1C to have a lower LogP value.,COCCOc1ccccc1CNc1cc(C)ccc1C,3.9407400000000026
+146386,Optimize the molecule COc1ccc([C@@]2(O)CC(c3ccc(F)cc3)=[N+]3CCCCCN32)cc1 to have a lower LogP value.,COc1ccc([C@@]2(O)CC(c3ccc(F)cc3)=[N+]3CCCCCN32)cc1,3.285800000000002
+211536,Modify the molecule NC(=O)CSc1ccccc1NC(=O)Cc1cccs1 to have a higher LogP value.,NC(=O)CSc1ccccc1NC(=O)Cc1cccs1,2.5067000000000013
+172704,Modify the molecule CCC(C)(C)NC(=O)[C@@H](C)S(=O)(=O)Cc1ccc(C(C)(C)C)cc1 to have a lower LogP value.,CCC(C)(C)NC(=O)[C@@H](C)S(=O)(=O)Cc1ccc(C(C)(C)C)cc1,3.5922000000000027
+245756,Please optimize the molecule C[C@@H]1CC[C@H](C(N)=O)CN1C(=O)c1ccc(Br)cc1F to have a lower LogP value.,C[C@@H]1CC[C@H](C(N)=O)CN1C(=O)c1ccc(Br)cc1F,2.3141999999999996
+170555,Please optimize the molecule O=C(OCc1ccc([N+](=O)[O-])cc1)[C@@H]1C[C@H]1c1ccccc1F to have a higher LogP value.,O=C(OCc1ccc([N+](=O)[O-])cc1)[C@@H]1C[C@H]1c1ccccc1F,3.5808000000000018
+207723,Optimize the molecule COc1cccc(CCNC(=O)c2cc3c(Cl)cccc3n2C)c1 to have a higher LogP value.,COc1cccc(CCNC(=O)c2cc3c(Cl)cccc3n2C)c1,3.812800000000002
+120324,Optimize the molecule C[C@H](C(=O)N1CCC[C@H](C(N)=O)C1)[NH+](C)Cc1cccc(N(C)C)c1 to have a lower LogP value.,C[C@H](C(=O)N1CCC[C@H](C(N)=O)C1)[NH+](C)Cc1cccc(N(C)C)c1,-0.12029999999999652
+47492,Please optimize the molecule C[C@@H]1C[C@H](NC(=O)CCCNC(=O)c2ccccc2)CN1c1ccccc1 to have a lower LogP value.,C[C@@H]1C[C@H](NC(=O)CCCNC(=O)c2ccccc2)CN1c1ccccc1,2.980200000000001
+242120,Optimize the molecule Cc1ccc([S@](=O)Cc2nc(-c3ccc(C(=O)NCc4ccccc4)cc3)oc2C)cc1 to have a lower LogP value.,Cc1ccc([S@](=O)Cc2nc(-c3ccc(C(=O)NCc4ccccc4)cc3)oc2C)cc1,5.196240000000005
+15252,Please optimize the molecule Cc1[nH]c(-c2ccc(OCC(=O)[O-])cc2)[nH+]c1C to have a higher LogP value.,Cc1[nH]c(-c2ccc(OCC(=O)[O-])cc2)[nH+]c1C,0.24133999999999972
+35096,Modify the molecule CNC(=S)N/N=C/c1cc(OC)cc(OC)c1 to have a higher LogP value.,CNC(=S)N/N=C/c1cc(OC)cc(OC)c1,1.1316
+202853,Please optimize the molecule CNC(=O)c1c(NC(=O)[C@H](C)SC)sc2c1-c1ccccc1C2 to have a lower LogP value.,CNC(=O)c1c(NC(=O)[C@H](C)SC)sc2c1-c1ccccc1C2,3.368900000000002
+72355,Modify the molecule COCC[C@H](C)C(=O)Nc1cc(F)ccc1Sc1nccn1C to have a higher LogP value.,COCC[C@H](C)C(=O)Nc1cc(F)ccc1Sc1nccn1C,3.3215000000000012
+85126,Modify the molecule CCCCC[C@H](Br)[C@H](C)c1ccncc1 to have a lower LogP value.,CCCCC[C@H](Br)[C@H](C)c1ccncc1,4.528900000000004
+149209,Optimize the molecule COc1ccc(COCCNC(=O)[C@@]2(C)CCCS2)cc1 to have a higher LogP value.,COc1ccc(COCCNC(=O)[C@@]2(C)CCCS2)cc1,2.6137000000000006
+196605,Modify the molecule O=C(NCc1cccnc1)C1CC[NH+](Cc2ccccc2O)CC1 to have a higher LogP value.,O=C(NCc1cccnc1)C1CC[NH+](Cc2ccccc2O)CC1,0.8985000000000001
+105862,Please modify the molecule Cc1nnc(SCC(=O)Nc2ccc(F)c(Cl)c2)n1-n1cccc1 to increase its LogP value.,Cc1nnc(SCC(=O)Nc2ccc(F)c(Cl)c2)n1-n1cccc1,3.2227200000000007
+77759,Please optimize the molecule CC(C)N(C(=O)[C@H](C)Oc1ccc(F)c(F)c1)C1CCC1 to have a higher LogP value.,CC(C)N(C(=O)[C@H](C)Oc1ccc(F)c(F)c1)C1CCC1,3.521600000000002
+167010,Modify the molecule C[C@H]1CC[C@H](C)N(C(=O)c2cc(C(C)(C)C)nn2C)C1 to decrease its LogP value.,C[C@H]1CC[C@H](C)N(C(=O)c2cc(C(C)(C)C)nn2C)C1,2.978200000000001
+51149,Please optimize the molecule O=C(CO)[C@H](O)[C@@H](O)CO to have a higher LogP value.,O=C(CO)[C@H](O)[C@@H](O)CO,-2.7381000000000006
+169625,Please modify the molecule O=c1[nH]ncc(N[C@@H]2CCCC[C@@H]2OC2CCCC2)c1Cl to increase its LogP value.,O=c1[nH]ncc(N[C@@H]2CCCC[C@@H]2OC2CCCC2)c1Cl,3.105600000000001
+100505,Please modify the molecule CCC[C@@H](C[NH3+])[C@H](O)CCC1CCCCC1 to decrease its LogP value.,CCC[C@@H](C[NH3+])[C@H](O)CCC1CCCCC1,2.3659999999999997
+229954,Optimize the molecule C[C@@H](CCO)N(Cc1ccccc1)C(=O)c1cc(C2CC2)[nH]n1 to have a lower LogP value.,C[C@@H](CCO)N(Cc1ccccc1)C(=O)c1cc(C2CC2)[nH]n1,2.7004
+25478,Please modify the molecule Cc1cccc(C)c1NC(=O)CCCN1CCOC[C@@H]1C1CC1 to increase its LogP value.,Cc1cccc(C)c1NC(=O)CCCN1CCOC[C@@H]1C1CC1,3.1329400000000014
+157950,Modify the molecule Cc1ccc([C@@H](O)CNC(=O)Nc2ccc(C)cc2F)cc1 to decrease its LogP value.,Cc1ccc([C@@H](O)CNC(=O)Nc2ccc(C)cc2F)cc1,3.2976400000000012
+195208,Please modify the molecule CN(C)C(=O)N1CCN(C(=O)Nc2ccc([N+](=O)[O-])cc2)CC1 to increase its LogP value.,CN(C)C(=O)N1CCN(C(=O)Nc2ccc([N+](=O)[O-])cc2)CC1,1.4259
+163348,Optimize the molecule COC[C@H](NC(=O)Cc1ccc(C)c(O)c1)c1ccc(C)o1 to have a lower LogP value.,COC[C@H](NC(=O)Cc1ccc(C)c(O)c1)c1ccc(C)o1,2.648440000000001
+14664,Modify the molecule CCN[C@@]1(C(=O)[O-])CC[C@H]([NH+]2CCC(C(C)(C)C)CC2)C1 to increase its LogP value.,CCN[C@@]1(C(=O)[O-])CC[C@H]([NH+]2CCC(C(C)(C)C)CC2)C1,-0.021899999999998032
+85533,Please modify the molecule Cn1c(C[C@@H](O)c2ccccc2Cl)nc2ccccc21 to increase its LogP value.,Cn1c(C[C@@H](O)c2ccccc2Cl)nc2ccccc21,3.5028000000000024
+17521,Please modify the molecule Cc1ccc(C)c(C[NH2+][C@H](C)c2ccc(C)c(F)c2)c1 to increase its LogP value.,Cc1ccc(C)c(C[NH2+][C@H](C)c2ccc(C)c(F)c2)c1,3.575560000000002
+4573,Modify the molecule O=C(NCCC1=CCCCC1)c1ccccc1O to increase its LogP value.,O=C(NCCC1=CCCCC1)c1ccccc1O,3.0125000000000024
+87596,Modify the molecule O=C(Cn1cccn1)NCc1ccc(C(=O)N2CCCC2)cc1 to decrease its LogP value.,O=C(Cn1cccn1)NCc1ccc(C(=O)N2CCCC2)cc1,1.4354999999999996
+235491,Please optimize the molecule CCCC[NH2+]Cc1cccc(OC)c1 to have a higher LogP value.,CCCC[NH2+]Cc1cccc(OC)c1,1.5586999999999995
+81250,Please modify the molecule CC(C)c1cc(C(=O)Nc2ccc(N3C(=O)CCCC3=O)cc2)n(C)n1 to decrease its LogP value.,CC(C)c1cc(C(=O)Nc2ccc(N3C(=O)CCCC3=O)cc2)n(C)n1,2.8393000000000015
+132346,Please modify the molecule COc1ccc(NS(=O)(=O)c2c(C)nc3sccn3c2=O)cc1 to decrease its LogP value.,COc1ccc(NS(=O)(=O)c2c(C)nc3sccn3c2=O)cc1,1.8738199999999998
+38463,Please optimize the molecule Cc1ccc(C)c(OC[C@H](O)Cn2cnc3c(Cl)cc(Cl)cc3c2=O)c1 to have a higher LogP value.,Cc1ccc(C)c(OC[C@H](O)Cn2cnc3c(Cl)cc(Cl)cc3c2=O)c1,3.7600400000000027
+59964,Please optimize the molecule CCN(C(=O)c1ccc(NC(=O)C2CC2)cc1)c1ccccc1C to have a higher LogP value.,CCN(C(=O)c1ccc(NC(=O)C2CC2)cc1)c1ccccc1C,4.010220000000003
+191096,Please optimize the molecule CC1(C)CSC[C@@]([NH2+]CCN=[N+]=[N-])(C(N)=O)C1 to have a higher LogP value.,CC1(C)CSC[C@@]([NH2+]CCN=[N+]=[N-])(C(N)=O)C1,0.2473000000000002
+6190,Modify the molecule C[NH+](C)CCCC[NH2+][C@@H]1CC(C)(C)OC1(C)C to have a lower LogP value.,C[NH+](C)CCCC[NH2+][C@@H]1CC(C)(C)OC1(C)C,-0.17939999999999645
+149569,Please modify the molecule Cc1ccc(NC(=O)C(=O)N[C@@H](C)C(C)(C)C[NH+](C)C)c(Cl)n1 to decrease its LogP value.,Cc1ccc(NC(=O)C(=O)N[C@@H](C)C(C)(C)C[NH+](C)C)c(Cl)n1,0.6573200000000008
+160756,Modify the molecule COc1ccc(CO/N=C(/N)[C@H]2CCOC2)cc1F to have a higher LogP value.,COc1ccc(CO/N=C(/N)[C@H]2CCOC2)cc1F,1.6596
+124654,Please modify the molecule COCCC(=O)N[C@@H](C)c1nnc2n1CCN(Cc1ccccc1C)CC2 to increase its LogP value.,COCCC(=O)N[C@@H](C)c1nnc2n1CCN(Cc1ccccc1C)CC2,1.8585199999999995
+184653,Optimize the molecule CSc1nc(-c2ccccc2)c(NC(=O)COc2ccccc2F)s1 to have a higher LogP value.,CSc1nc(-c2ccccc2)c(NC(=O)COc2ccccc2F)s1,4.688600000000001
+7988,Please modify the molecule CC1CC[NH+](CCCCNC(=O)c2ccc(-n3cc[nH]c3=S)cc2)CC1 to increase its LogP value.,CC1CC[NH+](CCCCNC(=O)c2ccc(-n3cc[nH]c3=S)cc2)CC1,2.3596899999999996
+25400,Please optimize the molecule CC1CCC([C@H]2OCCC[C@H]2C[NH2+]C(C)C)CC1 to have a lower LogP value.,CC1CCC([C@H]2OCCC[C@H]2C[NH2+]C(C)C)CC1,2.5797
+209054,Modify the molecule CC[C@H](C)[C@@H](C)[NH+](Cc1ccccc1NC(C)=O)C1CC1 to decrease its LogP value.,CC[C@H](C)[C@@H](C)[NH+](Cc1ccccc1NC(C)=O)C1CC1,2.6269
+230493,Please optimize the molecule CC(=O)c1ccccc1C(=O)N(C)[C@@H]1CCCN(c2ccccc2)C1=O to have a higher LogP value.,CC(=O)c1ccccc1C(=O)N(C)[C@@H]1CCCN(c2ccccc2)C1=O,3.1568000000000023
+232541,Optimize the molecule CCOC(=O)c1ccc(N2N=C(C)[C@@]3(Cc4ccccc4N4CCCC[C@@H]43)C2=O)cc1 to have a higher LogP value.,CCOC(=O)c1ccc(N2N=C(C)[C@@]3(Cc4ccccc4N4CCCC[C@@H]43)C2=O)cc1,4.187400000000004
+65624,Please modify the molecule CCS(=O)(=O)N1CCC(NC(=O)[C@H](C)N2C(=O)[C@H]3CC=CC[C@H]3C2=O)CC1 to decrease its LogP value.,CCS(=O)(=O)N1CCC(NC(=O)[C@H](C)N2C(=O)[C@H]3CC=CC[C@H]3C2=O)CC1,0.25640000000000085
+236601,Modify the molecule Cc1cc(-n2c(C)cc(C(=O)CSc3nnc(-c4cccnc4)n3C)c2C)no1 to have a higher LogP value.,Cc1cc(-n2c(C)cc(C(=O)CSc3nnc(-c4cccnc4)n3C)c2C)no1,3.5560600000000013
+240411,Modify the molecule C[C@H]1CN(c2cc(CNC(=O)CCCC(C)(C)C)cc[nH+]2)CCO1 to have a higher LogP value.,C[C@H]1CN(c2cc(CNC(=O)CCCC(C)(C)C)cc[nH+]2)CCO1,2.5584000000000007
+202455,Please modify the molecule CCOC(=O)/C(C#N)=C\c1ccc(N)cc1 to decrease its LogP value.,CCOC(=O)/C(C#N)=C\c1ccc(N)cc1,1.73888
+87614,Please optimize the molecule O=C(CCn1ncc(=O)c2ccccc21)Oc1ccccc1-c1ccccc1 to have a lower LogP value.,O=C(CCn1ncc(=O)c2ccccc21)Oc1ccccc1-c1ccccc1,4.059200000000002
+200741,Please optimize the molecule CN(C)C(=O)C[NH+]1CCC(NC(=O)/C=C/SCc2ccco2)CC1 to have a higher LogP value.,CN(C)C(=O)C[NH+]1CCC(NC(=O)/C=C/SCc2ccco2)CC1,0.27820000000000267
+116049,Modify the molecule Cc1ccc(S(C)(=O)=O)cc1C(=O)Nc1cncc2ccccc12 to increase its LogP value.,Cc1ccc(S(C)(=O)=O)cc1C(=O)Nc1cncc2ccccc12,3.1990200000000018
+223373,Modify the molecule COc1ccc([C@@H](C)NC(=O)c2cccc(Br)n2)c(OC)c1 to decrease its LogP value.,COc1ccc([C@@H](C)NC(=O)c2cccc(Br)n2)c(OC)c1,3.3523000000000014
+165741,Modify the molecule COC(=O)[C@H](C)NC(=O)c1cc2cc(C)c(C)cc2o1 to increase its LogP value.,COC(=O)[C@H](C)NC(=O)c1cc2cc(C)c(C)cc2o1,2.34094
+89454,Modify the molecule CCOc1cc(F)ccc1NC(=O)CC1(C(=O)[O-])CCCCC1 to have a lower LogP value.,CCOc1cc(F)ccc1NC(=O)CC1(C(=O)[O-])CCCCC1,2.2534
+81317,Please modify the molecule CCc1ccccc1NC(=O)C(=O)NC1CCCC1 to increase its LogP value.,CCc1ccccc1NC(=O)C(=O)NC1CCCC1,2.2462999999999997
+8664,Modify the molecule O=C(NC[C@@H]1CC[NH+](C2CC2)C1)N1CCN(c2nccs2)CC1 to have a lower LogP value.,O=C(NC[C@@H]1CC[NH+](C2CC2)C1)N1CCN(c2nccs2)CC1,0.041900000000000714
+35936,Please optimize the molecule Cc1sc(C(=O)NNC(=O)CCOc2ccccc2)cc1[N+](=O)[O-] to have a lower LogP value.,Cc1sc(C(=O)NNC(=O)CCOc2ccccc2)cc1[N+](=O)[O-],2.19482
+211219,Please modify the molecule CCOc1nc(-n2cnc3ccccc32)ccc1N to increase its LogP value.,CCOc1nc(-n2cnc3ccccc32)ccc1N,2.4013999999999998
+42537,Please optimize the molecule O=C1C[C@H](c2ccc3c(c2)OCO3)[C@H]2C(=O)[NH+]=c3ccccc3=C2O1 to have a higher LogP value.,O=C1C[C@H](c2ccc3c(c2)OCO3)[C@H]2C(=O)[NH+]=c3ccccc3=C2O1,-0.8891999999999989
+247768,Please modify the molecule CCCCC(=O)Nc1nc(-c2cc3cccc(OCC)c3o2)cs1 to increase its LogP value.,CCCCC(=O)Nc1nc(-c2cc3cccc(OCC)c3o2)cs1,5.083700000000004
+21947,Please modify the molecule O=C=Nc1ccc2c(c1)O[C@@H](F)C(F)(F)O2 to increase its LogP value.,O=C=Nc1ccc2c(c1)O[C@@H](F)C(F)(F)O2,2.3135000000000003
+52663,Optimize the molecule CC(C)(C)[C@H](NC(=O)c1cccc(C(F)(F)F)c1F)C(N)=O to have a higher LogP value.,CC(C)(C)[C@H](NC(=O)c1cccc(C(F)(F)F)c1F)C(N)=O,2.4742999999999995
+174829,Optimize the molecule CC[NH2+][C@@H](C)[C@@H]1CCCC(C)(C)CC1 to have a higher LogP value.,CC[NH2+][C@@H](C)[C@@H]1CCCC(C)(C)CC1,2.5647
+46443,Please optimize the molecule O=C(CCC(=O)N1CCOc2ccccc21)NCCCN1CCOCC1 to have a lower LogP value.,O=C(CCC(=O)N1CCOc2ccccc21)NCCCN1CCOCC1,1.0307000000000006
+131976,Modify the molecule Cn1ncnc1NC(=O)N1CCCN(c2nccs2)CC1 to have a lower LogP value.,Cn1ncnc1NC(=O)N1CCCN(c2nccs2)CC1,1.0158
+90118,Please modify the molecule CCOC(=O)c1c([O-])n(C)c2ccccc2c1=O to decrease its LogP value.,CCOC(=O)c1c([O-])n(C)c2ccccc2c1=O,0.7887999999999998
+58858,Please optimize the molecule CC(C)COc1ccc(Cc2c([O-])nc(N)[nH]c2=O)cc1 to have a higher LogP value.,CC(C)COc1ccc(Cc2c([O-])nc(N)[nH]c2=O)cc1,1.0513
+128578,Please modify the molecule CCCCC1CCC(C(=O)N2CCN(C(=O)[C@H]3CCCO3)CC2)CC1 to increase its LogP value.,CCCCC1CCC(C(=O)N2CCN(C(=O)[C@H]3CCCO3)CC2)CC1,2.8328000000000015
+34381,Modify the molecule CC(C)n1cnnc1[S@](=O)[C@@H](C)C(=O)N[C@@H](C)c1ccc(F)cc1 to decrease its LogP value.,CC(C)n1cnnc1[S@](=O)[C@@H](C)C(=O)N[C@@H](C)c1ccc(F)cc1,2.3716
+33707,Modify the molecule C[NH+](CCc1ccccc1F)C[C@@H]1CCCN(S(C)(=O)=O)C1 to decrease its LogP value.,C[NH+](CCc1ccccc1F)C[C@@H]1CCCN(S(C)(=O)=O)C1,0.5545000000000007
+40059,Optimize the molecule Cc1ccc([C@@H](CNC(=O)N2CCC(C)(C)C2)N2CCOCC2)cc1 to have a lower LogP value.,Cc1ccc([C@@H](CNC(=O)N2CCC(C)(C)C2)N2CCOCC2)cc1,2.809820000000001
+5785,Please modify the molecule C[C@@H]1CCN(C(=O)NCCC2CCCC2)C[C@@H]1O to increase its LogP value.,C[C@@H]1CCN(C(=O)NCCC2CCCC2)C[C@@H]1O,1.9790000000000005
+131799,Please modify the molecule COCCN1C(=O)/C(=C\C=C\c2ccccc2)SC1=S to increase its LogP value.,COCCN1C(=O)/C(=C\C=C\c2ccccc2)SC1=S,3.0904000000000016
+224023,Please optimize the molecule COC(=O)[C@@]1(F)CCN(c2cncc(-n3nc(C)cc3C)n2)C1 to have a lower LogP value.,COC(=O)[C@@]1(F)CCN(c2cncc(-n3nc(C)cc3C)n2)C1,1.3705399999999999
+246907,Modify the molecule CCn1cc(C(=O)NCc2ccc3c(c2)OCO3)c(=O)c2cc(S(=O)(=O)N3CCOCC3)ccc21 to decrease its LogP value.,CCn1cc(C(=O)NCc2ccc3c(c2)OCO3)c(=O)c2cc(S(=O)(=O)N3CCOCC3)ccc21,1.701
+182073,Please modify the molecule CC(C)(C)C(=O)NCCCc1cc(N)n(-c2ccccc2)n1 to decrease its LogP value.,CC(C)(C)C(=O)NCCCc1cc(N)n(-c2ccccc2)n1,2.549400000000001
+107508,Please modify the molecule Cc1cnc(-c2cccc(NC(=O)C(=O)NC[C@H](C(C)C)[NH+]3CCCC3)c2)o1 to decrease its LogP value.,Cc1cnc(-c2cccc(NC(=O)C(=O)NC[C@H](C(C)C)[NH+]3CCCC3)c2)o1,1.4080199999999998
+118213,Modify the molecule Cc1ccc(CN[C@@H](CC(F)(F)F)c2ccc(F)cc2)cc1[N+](=O)[O-] to increase its LogP value.,Cc1ccc(CN[C@@H](CC(F)(F)F)c2ccc(F)cc2)cc1[N+](=O)[O-],4.825620000000003
+15700,Modify the molecule O=C(CN1CCOCC1)N1CCN([C@@H]2CCN(c3ccccc3)C2=O)CC1 to decrease its LogP value.,O=C(CN1CCOCC1)N1CCN([C@@H]2CCN(c3ccccc3)C2=O)CC1,0.268300000000002
+106123,Please modify the molecule C[NH2+]C/C(C)=C/C1CCCCC1 to decrease its LogP value.,C[NH2+]C/C(C)=C/C1CCCCC1,1.7061999999999995
+16248,Please modify the molecule O=C(N[C@H](Cc1ccccc1)C(=O)N1CCC2(CC1)[NH2+]CCC1=NC=N[C@@H]12)c1ccc2c(c1)OCO2 to increase its LogP value.,O=C(N[C@H](Cc1ccccc1)C(=O)N1CCC2(CC1)[NH2+]CCC1=NC=N[C@@H]12)c1ccc2c(c1)OCO2,0.9362000000000019
+185448,Modify the molecule CN(C)c1ccc(CNc2cc(C(=O)[O-])[nH]n2)cc1 to increase its LogP value.,CN(C)c1ccc(CNc2cc(C(=O)[O-])[nH]n2)cc1,0.4512999999999995
+55649,Modify the molecule O=C(CCCC(=O)c1ccccc1)Nc1ccc(Cl)cn1 to decrease its LogP value.,O=C(CCCC(=O)c1ccccc1)Nc1ccc(Cl)cn1,3.726700000000002
+117931,Optimize the molecule CCN(Cc1ccnc(Cl)c1)Cc1cccc(C)n1 to have a lower LogP value.,CCN(Cc1ccnc(Cl)c1)Cc1cccc(C)n1,3.4605200000000025
+213002,Please optimize the molecule C[NH2+][C@H](c1cscc1C)[C@H]1CCOC2(CCC2)C1 to have a lower LogP value.,C[NH2+][C@H](c1cscc1C)[C@H]1CCOC2(CCC2)C1,2.6401200000000014
+23994,Optimize the molecule CC[N+](CC)=C1S[C@H]2CS(=O)(=O)C[C@H]2S1 to have a higher LogP value.,CC[N+](CC)=C1S[C@H]2CS(=O)(=O)C[C@H]2S1,1.0402999999999998
+11490,Please optimize the molecule C[C@H](Cc1ccsc1)NC(=O)[C@H]1C=C[C@@H]([NH3+])C1 to have a higher LogP value.,C[C@H](Cc1ccsc1)NC(=O)[C@H]1C=C[C@@H]([NH3+])C1,0.9819
+103731,Please optimize the molecule COC[C@@H]1CCCN(C(=O)Cc2cccc(OC)c2)C1 to have a lower LogP value.,COC[C@@H]1CCCN(C(=O)Cc2cccc(OC)c2)C1,2.1227
+96491,Modify the molecule C#Cc1cccc(N(C(=O)[C@H]2Cc3ccccc3O2)C(C)C)c1 to decrease its LogP value.,C#Cc1cccc(N(C(=O)[C@H]2Cc3ccccc3O2)C(C)C)c1,3.413000000000002
+110066,Modify the molecule CCCN[C@]1(C#N)CCC[C@@H](n2cc(I)cn2)C1 to decrease its LogP value.,CCCN[C@]1(C#N)CCC[C@@H](n2cc(I)cn2)C1,2.8647800000000014
+85711,Please optimize the molecule CCc1nc2n(n1)CCC[C@H]2NC(=O)[C@@H]1CCC[C@H](C(F)(F)F)C1 to have a lower LogP value.,CCc1nc2n(n1)CCC[C@H]2NC(=O)[C@@H]1CCC[C@H](C(F)(F)F)C1,3.160300000000002
+58188,Optimize the molecule Cc1cccc(SCc2cc(N)cc[nH+]2)c1 to have a lower LogP value.,Cc1cccc(SCc2cc(N)cc[nH+]2)c1,2.6836200000000003
+215419,Modify the molecule COc1ccccc1COC1CCN(C(=O)N[C@H]2C[C@@H]2c2ccccc2)CC1 to have a lower LogP value.,COc1ccccc1COC1CCN(C(=O)N[C@H]2C[C@@H]2c2ccccc2)CC1,3.941900000000003
+152003,Please modify the molecule COCCCN1C(=O)c2[nH]nc(-c3ccccc3)c2[C@H]1c1cccc(F)c1 to increase its LogP value.,COCCCN1C(=O)c2[nH]nc(-c3ccccc3)c2[C@H]1c1cccc(F)c1,3.797500000000003
+216449,Modify the molecule O=C(NCc1cccc([N+](=O)[O-])c1)Nc1ccc2c(c1)CCC2 to decrease its LogP value.,O=C(NCc1cccc([N+](=O)[O-])c1)Nc1ccc2c(c1)CCC2,3.4052000000000016
+31240,Modify the molecule O=C(NCCC[NH+]1CCCC1)C1CCN(S(=O)(=O)c2ccc(F)cc2F)CC1 to have a higher LogP value.,O=C(NCCC[NH+]1CCCC1)C1CCN(S(=O)(=O)c2ccc(F)cc2F)CC1,0.5505000000000013
+4601,Please modify the molecule CC(C)N(CC#N)C(=O)CC12CC3CC(CC(C3)C1)C2 to decrease its LogP value.,CC(C)N(CC#N)C(=O)CC12CC3CC(CC(C3)C1)C2,3.353480000000002
+216147,Modify the molecule CC(C)Oc1cccc(-c2nnc(CCC(=O)N3CCSCC3)c([O-])n2)c1 to have a lower LogP value.,CC(C)Oc1cccc(-c2nnc(CCC(=O)N3CCSCC3)c([O-])n2)c1,1.9073999999999998
+214396,Modify the molecule FC(F)(F)c1ccc(NN2CCCCC2)cn1 to increase its LogP value.,FC(F)(F)c1ccc(NN2CCCCC2)cn1,2.9132000000000007
+167824,Modify the molecule CN(CC(=O)NC(C)(C)C)C(=O)c1cc(N2CCCC2=O)ccc1Cl to increase its LogP value.,CN(CC(=O)NC(C)(C)C)C(=O)c1cc(N2CCCC2=O)ccc1Cl,2.4535
+220261,Optimize the molecule COc1nc2ccccc2nc1NC[C@@H]1CCN(C(=O)OC(C)(C)C)C1 to have a higher LogP value.,COc1nc2ccccc2nc1NC[C@@H]1CCN(C(=O)OC(C)(C)C)C1,3.3073000000000023
+112919,Modify the molecule Cc1nc(NC[C@H]([C@@H]2CCOC2)N2CCOCC2)c2cc[nH]c2n1 to increase its LogP value.,Cc1nc(NC[C@H]([C@@H]2CCOC2)N2CCOCC2)c2cc[nH]c2n1,1.4155199999999997
+172454,Modify the molecule C[C@H](CN(C)C(=O)CCc1nc2ccccc2o1)C(=O)[O-] to increase its LogP value.,C[C@H](CN(C)C(=O)CCc1nc2ccccc2o1)C(=O)[O-],0.6048
+86026,Please optimize the molecule O[C@@H](C[C@@H]1CCC[NH+]1Cc1cc[nH]n1)c1cccs1 to have a higher LogP value.,O[C@@H](C[C@@H]1CCC[NH+]1Cc1cc[nH]n1)c1cccs1,1.1421999999999997
+43411,Please optimize the molecule CC[C@H](C)NC(=O)CCNC(=O)NCc1cccc(C)n1 to have a lower LogP value.,CC[C@H](C)NC(=O)CCNC(=O)NCc1cccc(C)n1,1.4940199999999995
+149900,Modify the molecule C[N+](C)([O-])CC[C@H](c1ccc(Cl)cc1)c1ccccn1 to increase its LogP value.,C[N+](C)([O-])CC[C@H](c1ccc(Cl)cc1)c1ccccn1,3.8312000000000026
+238441,Modify the molecule CCS(=O)(=O)c1ccc([C@H](C)N[C@@H](C)c2csc(C(C)C)n2)cc1 to decrease its LogP value.,CCS(=O)(=O)c1ccc([C@H](C)N[C@@H](C)c2csc(C(C)C)n2)cc1,4.471900000000003
+53894,Please modify the molecule Cc1nccn1-c1cncc(N2CC[NH+]3CCCC[C@@H]3C2)n1 to increase its LogP value.,Cc1nccn1-c1cncc(N2CC[NH+]3CCCC[C@@H]3C2)n1,0.22812000000000032
+224364,Please optimize the molecule C=CCN(CC=C)C(=O)[C@@H](C)Nc1ccc2c(c1)OCCO2 to have a lower LogP value.,C=CCN(CC=C)C(=O)[C@@H](C)Nc1ccc2c(c1)OCCO2,2.4588
+171695,Modify the molecule CC(=O)N1CCc2ccccc2[C@@H]1CC(=O)N1Cc2ccccc2C[C@H]1C(N)=O to have a higher LogP value.,CC(=O)N1CCc2ccccc2[C@@H]1CC(=O)N1Cc2ccccc2C[C@H]1C(N)=O,1.9612
+124745,Modify the molecule COc1nn(C)cc1C(=O)Nc1nc2c(cc3c4c(cccc42)CC3)s1 to decrease its LogP value.,COc1nn(C)cc1C(=O)Nc1nc2c(cc3c4c(cccc42)CC3)s1,3.542500000000002
+57762,Modify the molecule CC(/C=C/c1ccco1)=N\NC1=N[C@@H]2[NH+]=c3ccccc3=C2N=[NH+]1 to have a higher LogP value.,CC(/C=C/c1ccco1)=N\NC1=N[C@@H]2[NH+]=c3ccccc3=C2N=[NH+]1,-1.990999999999996
+150986,Please optimize the molecule O=C(CNC(=O)N1CC(O)=Nc2ccccc21)Nc1nccs1 to have a lower LogP value.,O=C(CNC(=O)N1CC(O)=Nc2ccccc21)Nc1nccs1,1.8994
+16879,Modify the molecule O=C(Nc1ccc2c(c1)Cc1ccccc1-2)c1cc(=O)c2ccccc2o1 to decrease its LogP value.,O=C(Nc1ccc2c(c1)Cc1ccccc1-2)c1cc(=O)c2ccccc2o1,4.616500000000003
+173522,Please optimize the molecule Cc1cc2nc(SCC(=O)N3CCN(c4ccc(F)cc4)CC3)n(-c3ccc(F)cc3)c(=O)c2[nH]1 to have a higher LogP value.,Cc1cc2nc(SCC(=O)N3CCN(c4ccc(F)cc4)CC3)n(-c3ccc(F)cc3)c(=O)c2[nH]1,3.7413200000000018
+222848,Please modify the molecule Cc1noc2ncnc(N3CC[C@@H](NC(=O)c4ccccn4)[C@H](O)C3)c12 to increase its LogP value.,Cc1noc2ncnc(N3CC[C@@H](NC(=O)c4ccccn4)[C@H](O)C3)c12,0.6908199999999995
+96003,Modify the molecule Cc1n[nH]cc1CNC(=O)CSc1ccc(Br)cc1 to decrease its LogP value.,Cc1n[nH]cc1CNC(=O)CSc1ccc(Br)cc1,2.889120000000001
+60924,Modify the molecule C[C@@H]1CCN(C(=O)NCCCc2ccc(N(C)C)cc2)C[C@@H]1O to have a lower LogP value.,C[C@@H]1CCN(C(=O)NCCCc2ccc(N(C)C)cc2)C[C@@H]1O,2.0975000000000006
+122857,Modify the molecule CC(C)(C)n1nnn(CN(Cc2cccs2)CC(F)(F)F)c1=S to have a lower LogP value.,CC(C)(C)n1nnn(CN(Cc2cccs2)CC(F)(F)F)c1=S,3.6475900000000028
+95019,Modify the molecule COc1cc2c(cc1OC)[C@@H]1c3ccccc3[C@](C#N)(C2)N(C(=O)c2ccccc2)[C@@H]1O to have a higher LogP value.,COc1cc2c(cc1OC)[C@@H]1c3ccccc3[C@](C#N)(C2)N(C(=O)c2ccccc2)[C@@H]1O,3.585080000000002
+13999,Modify the molecule CC[NH+](CC)C1(C(=O)c2ccc(F)cc2)CCCC1 to decrease its LogP value.,CC[NH+](CC)C1(C(=O)c2ccc(F)cc2)CCCC1,2.2459
+111332,Modify the molecule CC(C)Oc1cccc(/C=C/C(=O)NCc2ccc[nH]2)c1 to have a lower LogP value.,CC(C)Oc1cccc(/C=C/C(=O)NCc2ccc[nH]2)c1,3.131500000000001
+91356,Optimize the molecule C#CCN(C(=O)NC1CC1)[C@@H]1CCS(=O)(=O)C1 to have a higher LogP value.,C#CCN(C(=O)NC1CC1)[C@@H]1CCS(=O)(=O)C1,-0.019300000000000095
+76536,Modify the molecule C[C@@H](Cn1cc(Br)cn1)N[C@@H]1CCN(C2CCCCC2)C1=O to increase its LogP value.,C[C@@H](Cn1cc(Br)cn1)N[C@@H]1CCN(C2CCCCC2)C1=O,2.5573000000000006
+16946,Modify the molecule Cc1cc(N2CCC([NH2+]CCO)CC2)n2c(nc3ccccc32)c1C#N to increase its LogP value.,Cc1cc(N2CCC([NH2+]CCO)CC2)n2c(nc3ccccc32)c1C#N,1.1921000000000006
+47522,Please optimize the molecule Cn1ncnc1CNC(=O)C(=O)Nc1ccc(OC(F)(F)F)cc1 to have a lower LogP value.,Cn1ncnc1CNC(=O)C(=O)Nc1ccc(OC(F)(F)F)cc1,0.9686000000000002
+183447,Optimize the molecule CC[C@@H](C)NS(=O)(=O)c1ccc(S(=O)(=O)N2CCN(c3nc4ccccc4s3)CC2)cc1 to have a higher LogP value.,CC[C@@H](C)NS(=O)(=O)c1ccc(S(=O)(=O)N2CCN(c3nc4ccccc4s3)CC2)cc1,2.8840000000000012
+206956,Optimize the molecule CCN(Cc1cccc(C)c1)C(=O)CNC(=O)Cc1ccccc1 to have a lower LogP value.,CCN(Cc1cccc(C)c1)C(=O)CNC(=O)Cc1ccccc1,2.702420000000001
+134776,Please modify the molecule Cc1cc(C)n(-c2nc3c(c(=O)n(CCC(C)C)c(=O)n3C)n2C)n1 to increase its LogP value.,Cc1cc(C)n(-c2nc3c(c(=O)n(CCC(C)C)c(=O)n3C)n2C)n1,1.2823399999999998
+54803,Please modify the molecule CC(=O)CSc1ncc2cnccn12 to decrease its LogP value.,CC(=O)CSc1ncc2cnccn12,1.4103999999999999
+214895,Optimize the molecule CCc1ccc(Oc2ncnc(Oc3ccccc3)c2N)cc1 to have a lower LogP value.,CCc1ccc(Oc2ncnc(Oc3ccccc3)c2N)cc1,4.205800000000003
+28490,Modify the molecule C=CCN1C(=O)S/C(=C/c2ccccc2[N+](=O)[O-])C1=O to increase its LogP value.,C=CCN1C(=O)S/C(=C/c2ccccc2[N+](=O)[O-])C1=O,2.817100000000001
+121622,Please modify the molecule CC[C@H](NC(=O)N1CCCN(c2nccs2)CC1)c1ccc(OC)cc1 to increase its LogP value.,CC[C@H](NC(=O)N1CCCN(c2nccs2)CC1)c1ccc(OC)cc1,3.524700000000003
+140444,Modify the molecule CCC1(CC)Nc2c(c(C)nn2C)NC1=O to have a lower LogP value.,CCC1(CC)Nc2c(c(C)nn2C)NC1=O,1.6513199999999997
+111117,Optimize the molecule O=C(Nc1nnc(Cc2c[nH]c3ccccc23)s1)c1ccccc1 to have a lower LogP value.,O=C(Nc1nnc(Cc2c[nH]c3ccccc23)s1)c1ccccc1,3.8625000000000016
+63564,Modify the molecule CC(C)c1ccc(OCC(=O)N2CCOC23CCCCC3)cc1 to have a lower LogP value.,CC(C)c1ccc(OCC(=O)N2CCOC23CCCCC3)cc1,3.708000000000003
+223216,Please optimize the molecule CCCn1c(=O)c2ccccc2n(CC(=O)Nc2ccccc2)c1=O to have a higher LogP value.,CCCn1c(=O)c2ccccc2n(CC(=O)Nc2ccccc2)c1=O,2.2119
+169091,Please optimize the molecule CN(C(=O)c1cccc(C(F)(F)F)c1F)c1cccc2ncccc12 to have a lower LogP value.,CN(C(=O)c1cccc(C(F)(F)F)c1F)c1cccc2ncccc12,4.669300000000003
+23858,Please modify the molecule Cc1cc(CNC(=O)CCc2nc3ccccc3[nH]2)ccc1F to increase its LogP value.,Cc1cc(CNC(=O)CCc2nc3ccccc3[nH]2)ccc1F,3.2594200000000013
+30931,Please modify the molecule C[C@@H]1CCN(C(=O)CCCc2ccccc2)C[C@@H]1O to increase its LogP value.,C[C@@H]1CCN(C(=O)CCCc2ccccc2)C[C@@H]1O,2.2386000000000004
+40516,Optimize the molecule Cc1nc(C)c(C[NH2+][C@@H]2c3ccccc3C[C@H]2C)s1 to have a lower LogP value.,Cc1nc(C)c(C[NH2+][C@@H]2c3ccccc3C[C@H]2C)s1,2.7568400000000013
+132823,Modify the molecule O=C(NC[C@@H](CCO)c1ccccc1)c1ccn(-c2ccccc2)n1 to decrease its LogP value.,O=C(NC[C@@H](CCO)c1ccccc1)c1ccn(-c2ccccc2)n1,2.768300000000001
+162429,Please optimize the molecule N#C/C(=C\C1=Cc2ccccc2OC1)C(=O)c1cccc2c1OCCO2 to have a lower LogP value.,N#C/C(=C\C1=Cc2ccccc2OC1)C(=O)c1cccc2c1OCCO2,3.566480000000001
+67257,Please optimize the molecule C[C@H](Cc1cccs1)N(C)S(=O)(=O)c1cnc(Cl)nc1 to have a lower LogP value.,C[C@H](Cc1cccs1)N(C)S(=O)(=O)c1cnc(Cl)nc1,2.4432
+163433,Modify the molecule CCCC(=O)Nc1ccc(CNC(=O)c2ccc(-n3ccnc3)cc2)cc1 to have a higher LogP value.,CCCC(=O)Nc1ccc(CNC(=O)c2ccc(-n3ccnc3)cc2)cc1,3.5409000000000015
+66057,Modify the molecule C[C@@H](NC(=O)Nc1ccccc1CS(C)(=O)=O)c1ccc2ccccc2c1 to have a higher LogP value.,C[C@@H](NC(=O)Nc1ccccc1CS(C)(=O)=O)c1ccc2ccccc2c1,4.267100000000004
+36530,Modify the molecule Cc1cc(C)nc(SCc2ccccc2C(=O)N2CCN(Cc3ccc(C#N)cc3)CC2)n1 to increase its LogP value.,Cc1cc(C)nc(SCc2ccccc2C(=O)N2CCN(Cc3ccc(C#N)cc3)CC2)n1,4.2154200000000035
+118833,Please modify the molecule CCCOc1ccc2ccccc2c1C[NH2+]Cc1ccco1 to increase its LogP value.,CCCOc1ccc2ccccc2c1C[NH2+]Cc1ccco1,3.4852000000000016
+78141,Please modify the molecule O=C(CC1C[C@@H]2CC[C@H](C1)[NH2+]2)NCCc1ccc(Cl)cc1 to increase its LogP value.,O=C(CC1C[C@@H]2CC[C@H](C1)[NH2+]2)NCCc1ccc(Cl)cc1,1.8932000000000004
+68533,Modify the molecule COC(=O)c1cc(CNC(=O)N[C@H]2CCC[C@@H](C(F)(F)F)C2)oc1C to decrease its LogP value.,COC(=O)c1cc(CNC(=O)N[C@H]2CCC[C@@H](C(F)(F)F)C2)oc1C,3.294920000000002
+192019,Modify the molecule Fc1ccc(-c2nc(COc3ccccc3)co2)cc1 to have a lower LogP value.,Fc1ccc(-c2nc(COc3ccccc3)co2)cc1,4.059700000000002
+133626,Please modify the molecule C[C@H]([NH2+]Cc1ccc(Br)cc1)C1CC[NH+](C)CC1 to decrease its LogP value.,C[C@H]([NH2+]Cc1ccc(Br)cc1)C1CC[NH+](C)CC1,0.8256999999999999
+143220,Please optimize the molecule COc1cc(NC(=O)[C@H]2CCC[NH+](Cc3ccccc3)C2)ccc1NC(=O)c1cccnc1 to have a higher LogP value.,COc1cc(NC(=O)[C@H]2CCC[NH+](Cc3ccccc3)C2)ccc1NC(=O)c1cccnc1,2.7760999999999996
+46306,Please modify the molecule COC(=O)[C@@H](C)O/N=C1\C=C[C@@](C)(C(Cl)(Cl)Cl)C=C1C to decrease its LogP value.,COC(=O)[C@@H](C)O/N=C1\C=C[C@@](C)(C(Cl)(Cl)Cl)C=C1C,3.813100000000003
+63671,Modify the molecule O=C(Cn1c(C(=O)c2cccc(F)c2)nc2ccccc21)NCc1ccc(Cl)cc1 to increase its LogP value.,O=C(Cn1c(C(=O)c2cccc(F)c2)nc2ccccc21)NCc1ccc(Cl)cc1,4.376200000000003
+84149,Please modify the molecule C#CCNC(=O)c1ccc(NC[C@H]2CCC[NH+](C)C2)nc1 to increase its LogP value.,C#CCNC(=O)c1ccc(NC[C@H]2CCC[NH+](C)C2)nc1,-0.21879999999999833
+234677,Optimize the molecule O=c1oc2cccnc2n1CC[NH+]1CCC[C@@H]1c1ccccc1 to have a lower LogP value.,O=c1oc2cccnc2n1CC[NH+]1CCC[C@@H]1c1ccccc1,1.409499999999999
+199775,Optimize the molecule CCc1noc(CC)c1CNC(=O)NCC(C)(C)c1cccc(F)c1 to have a lower LogP value.,CCc1noc(CC)c1CNC(=O)NCC(C)(C)c1cccc(F)c1,3.7155000000000022
+209435,Optimize the molecule O=[N+]([O-])c1ccc(/C=N/N[C@H]2N=NNN2)s1 to have a lower LogP value.,O=[N+]([O-])c1ccc(/C=N/N[C@H]2N=NNN2)s1,0.33839999999999987
+71842,Please modify the molecule C[NH+](C)CCCN1C(=O)C([O-])=C(C(=O)c2ccc3ccccc3c2O)[C@H]1c1ccccc1 to decrease its LogP value.,C[NH+](C)CCCN1C(=O)C([O-])=C(C(=O)c2ccc3ccccc3c2O)[C@H]1c1ccccc1,1.4606000000000012
+230055,Modify the molecule NC(=O)c1cc(NC(=O)c2ccc(Cl)c(Cl)c2)c(F)cc1F to have a higher LogP value.,NC(=O)c1cc(NC(=O)c2ccc(Cl)c(Cl)c2)c(F)cc1F,3.6228000000000007
+206074,Modify the molecule Cn1nnn([C@@H]2CC(=O)[C@H]3OC[C@@H]2O3)c1=S to have a lower LogP value.,Cn1nnn([C@@H]2CC(=O)[C@H]3OC[C@@H]2O3)c1=S,-0.3985099999999999
+203364,Please modify the molecule C#CCN1CCN(S(=O)(=O)CCC2CC2)CC1 to decrease its LogP value.,C#CCN1CCN(S(=O)(=O)CCC2CC2)CC1,0.36709999999999976
+124182,Modify the molecule COc1ccc(OC)c(NC(=O)C2=C(C)NC(=O)N[C@@H]2c2ccc(O)cc2)c1 to decrease its LogP value.,COc1ccc(OC)c(NC(=O)C2=C(C)NC(=O)N[C@@H]2c2ccc(O)cc2)c1,2.676
+157982,Optimize the molecule COc1ccccc1NC(=O)c1cccc(C)c1OC to have a lower LogP value.,COc1ccccc1NC(=O)c1cccc(C)c1OC,3.264520000000002
+147988,Modify the molecule Cc1cc([C@H]2CCCN(C(=O)c3cc(Br)c[nH]3)C2)n[nH]1 to have a higher LogP value.,Cc1cc([C@H]2CCCN(C(=O)c3cc(Br)c[nH]3)C2)n[nH]1,2.82852
+193720,Please optimize the molecule Cc1ccc(NC(=O)[C@@H]2[C@@H](C(=O)[O-])[C@@H]3C=C[C@H]2C3)cc1NC(=O)c1ccc(Cl)cc1 to have a lower LogP value.,Cc1ccc(NC(=O)[C@@H]2[C@@H](C(=O)[O-])[C@@H]3C=C[C@H]2C3)cc1NC(=O)c1ccc(Cl)cc1,3.027420000000001
+248404,Please modify the molecule Nc1cc(N)nc(SCC(=O)Nc2ccc(F)c(F)c2)n1 to increase its LogP value.,Nc1cc(N)nc(SCC(=O)Nc2ccc(F)c(F)c2)n1,1.65
+168430,Optimize the molecule [NH3+][C@@H](CO)c1cc(Cl)ccc1Cl to have a higher LogP value.,[NH3+][C@@H](CO)c1cc(Cl)ccc1Cl,1.2687000000000006
+80338,Please modify the molecule CC(C)[NH2+]C[C@](C)(O)c1ccccc1 to increase its LogP value.,CC(C)[NH2+]C[C@](C)(O)c1ccccc1,0.8659000000000003
+228946,Modify the molecule Cc1ncn(C[C@H](C)[NH2+][C@H](C)C2CCCCC2)c1C to decrease its LogP value.,Cc1ncn(C[C@H](C)[NH2+][C@H](C)C2CCCCC2)c1C,2.4206399999999997
+173435,Modify the molecule C[C@H](C[C@@H]1CCCC[NH2+]1)Nc1ccc(OCC#N)cc1 to have a lower LogP value.,C[C@H](C[C@@H]1CCCC[NH2+]1)Nc1ccc(OCC#N)cc1,1.8953799999999992
+47676,Modify the molecule Cc1ccc(C(=O)C[C@]2(O)C(=O)N(C)c3ccc(Cl)cc32)c(C)c1 to decrease its LogP value.,Cc1ccc(C(=O)C[C@]2(O)C(=O)N(C)c3ccc(Cl)cc32)c(C)c1,3.3938400000000017
+33728,Modify the molecule Cn1ccnc1-c1sc(NC(=O)c2ccccc2Br)nc1-c1ccccc1 to have a lower LogP value.,Cn1ccnc1-c1sc(NC(=O)c2ccccc2Br)nc1-c1ccccc1,5.225400000000003
+28216,Modify the molecule O=C(CCc1ccsc1)N(C[C@@H]1CCCO1)c1nc2ccccc2s1 to decrease its LogP value.,O=C(CCc1ccsc1)N(C[C@@H]1CCCO1)c1nc2ccccc2s1,4.502600000000004
+121865,Please modify the molecule O=C(Nc1nc2ccc(F)cc2s1)c1ccccc1[N-]S(=O)(=O)c1ccccc1 to decrease its LogP value.,O=C(Nc1nc2ccc(F)cc2s1)c1ccccc1[N-]S(=O)(=O)c1ccccc1,5.081800000000003
+224612,Modify the molecule C[C@@H](Oc1ccccc1C#N)/C([O-])=N/c1nc(C(F)(F)F)n[nH]1 to have a higher LogP value.,C[C@@H](Oc1ccccc1C#N)/C([O-])=N/c1nc(C(F)(F)F)n[nH]1,1.5529799999999998
+143647,Optimize the molecule CCC(CC)N(C)C(=O)Nc1ccc2c(c1)CCN2C(C)=O to have a higher LogP value.,CCC(CC)N(C)C(=O)Nc1ccc2c(c1)CCN2C(C)=O,3.2479000000000022
+236989,Please optimize the molecule C[C@H](O)[C@H](C)Oc1cc(F)ccc1[C@@H](C)[NH3+] to have a higher LogP value.,C[C@H](O)[C@H](C)Oc1cc(F)ccc1[C@@H](C)[NH3+],1.2767
+139062,Please optimize the molecule C[C@H](c1ccncn1)N(C)C(=O)c1csc2nc(-c3ccc(F)cc3)cn12 to have a higher LogP value.,C[C@H](c1ccncn1)N(C)C(=O)c1csc2nc(-c3ccc(F)cc3)cn12,3.8251000000000026
+28599,Optimize the molecule Cc1nn(Cc2ccc(C(=O)Nc3cc(C[NH+](C)C)n[nH]3)o2)c(C)c1Br to have a lower LogP value.,Cc1nn(Cc2ccc(C(=O)Nc3cc(C[NH+](C)C)n[nH]3)o2)c(C)c1Br,1.5236399999999999
+79159,Please modify the molecule C[C@@H]1CS(=O)(=O)N(c2ccc(S(=O)(=O)N3CCN(c4ncccn4)CC3)cc2)C1=O to decrease its LogP value.,C[C@@H]1CS(=O)(=O)N(c2ccc(S(=O)(=O)N3CCN(c4ncccn4)CC3)cc2)C1=O,0.30000000000000004
+80323,Modify the molecule Cc1ccc(C)n1-c1ccc(C(=O)N/N=C/c2cc([N+](=O)[O-])ccc2Cl)cc1 to decrease its LogP value.,Cc1ccc(C)n1-c1ccc(C(=O)N/N=C/c2cc([N+](=O)[O-])ccc2Cl)cc1,4.419640000000003
+12189,Modify the molecule CSCC[C@H](C(=O)Nc1ccc(C(C)=O)cc1)N1C(=O)c2ccccc2C1=O to have a lower LogP value.,CSCC[C@H](C(=O)Nc1ccc(C(C)=O)cc1)N1C(=O)c2ccccc2C1=O,3.2456000000000023
+134629,Modify the molecule COc1ccc(-c2[nH]c3ccccc3c2CCC(=O)N(C)c2ccccc2)cc1 to have a higher LogP value.,COc1ccc(-c2[nH]c3ccccc3c2CCC(=O)N(C)c2ccccc2)cc1,5.439100000000004
+166575,Modify the molecule O=C(CSc1nnc(-c2c[nH]c3ccccc23)n1C1CC1)c1ccccc1 to decrease its LogP value.,O=C(CSc1nnc(-c2c[nH]c3ccccc23)n1C1CC1)c1ccccc1,4.7363000000000035
+183917,Please modify the molecule [NH3+]C[C@H]1CC[C@H](C(=O)OC[C@H]2CCCO2)O1 to decrease its LogP value.,[NH3+]C[C@H]1CC[C@H](C(=O)OC[C@H]2CCCO2)O1,-0.5018999999999993
+32357,Please optimize the molecule Cc1ncsc1CN1CCN(Cc2scnc2C)CC1 to have a higher LogP value.,Cc1ncsc1CN1CCN(Cc2scnc2C)CC1,2.5342400000000005
+3284,Optimize the molecule CCc1ccsc1CNC(=O)C(=O)Nc1cc(F)cc(F)c1 to have a higher LogP value.,CCc1ccsc1CNC(=O)C(=O)Nc1cc(F)cc(F)c1,2.8436000000000003
+173058,Optimize the molecule CC(=O)N[C@H]1CCCN(C(=O)c2cccc[n+]2[O-])C1 to have a higher LogP value.,CC(=O)N[C@H]1CCCN(C(=O)c2cccc[n+]2[O-])C1,0.0607000000000002
+67106,Please optimize the molecule [NH3+][C@H](Cc1ccccc1Br)[C@@H]1CCOC2(CCOCC2)C1 to have a higher LogP value.,[NH3+][C@H](Cc1ccccc1Br)[C@@H]1CCOC2(CCOCC2)C1,2.5779000000000005
+71552,Modify the molecule COCc1cc(C(=O)N(C)Cc2nnc(C3CC3)n2C)ccc1F to have a higher LogP value.,COCc1cc(C(=O)N(C)Cc2nnc(C3CC3)n2C)ccc1F,2.2502000000000004
+184970,Modify the molecule O=C(c1cc(Cl)ccc1[N+](=O)[O-])N1CCCc2cc(F)ccc21 to have a lower LogP value.,O=C(c1cc(Cl)ccc1[N+](=O)[O-])N1CCCc2cc(F)ccc21,3.9803000000000024
+109017,Modify the molecule COc1ccccc1/C=C/C(=O)Nc1cc(N2CCOC2=O)ccc1C to have a higher LogP value.,COc1ccccc1/C=C/C(=O)Nc1cc(N2CCOC2=O)ccc1C,3.6121200000000018
+223488,Optimize the molecule Cc1cc(OC(C)(C)C(=O)N[C@H](C)[C@@H]2CCCO2)ccc1Cl to have a lower LogP value.,Cc1cc(OC(C)(C)C(=O)N[C@H](C)[C@@H]2CCCO2)ccc1Cl,3.4895200000000024
+238226,Modify the molecule C[C@H](NC(=O)NC12CC3CC(CC(C3)C1)C2)c1ccc2c(c1)NC(=O)CO2 to have a higher LogP value.,C[C@H](NC(=O)NC12CC3CC(CC(C3)C1)C2)c1ccc2c(c1)NC(=O)CO2,3.3465000000000016
+54724,Modify the molecule O=C(Nc1ccc(NC(=O)[C@@H]2CCCC[C@H]2C(=O)[O-])cc1)c1ccco1 to have a higher LogP value.,O=C(Nc1ccc(NC(=O)[C@@H]2CCCC[C@H]2C(=O)[O-])cc1)c1ccco1,2.0267
+7685,Please optimize the molecule CC(C)(C)c1cc(C(=O)[C@H](C#N)c2nc3cc(Cl)ccc3s2)[nH]n1 to have a higher LogP value.,CC(C)(C)c1cc(C(=O)[C@H](C#N)c2nc3cc(Cl)ccc3s2)[nH]n1,4.4603800000000025
+22904,Please optimize the molecule Cc1oc(-c2cccs2)nc1COc1nnc(-c2ccccc2)o1 to have a higher LogP value.,Cc1oc(-c2cccs2)nc1COc1nnc(-c2ccccc2)o1,4.340520000000003
+112774,Modify the molecule NC(=S)[C@@H]1CN(c2snc3ccccc23)CCO1 to increase its LogP value.,NC(=S)[C@@H]1CN(c2snc3ccccc23)CCO1,1.7876
+172198,Optimize the molecule CC[NH+](C)Cc1ccc(C(=O)NCc2cnc3ccccc3c2)c(=O)[nH]1 to have a lower LogP value.,CC[NH+](C)Cc1ccc(C(=O)NCc2cnc3ccccc3c2)c(=O)[nH]1,0.8876999999999999
+76248,Please optimize the molecule O=C(c1ccc2cc[nH]c2c1)N(C[C@@H]1CCCO1)[C@H]1CCS(=O)(=O)C1 to have a lower LogP value.,O=C(c1ccc2cc[nH]c2c1)N(C[C@@H]1CCCO1)[C@H]1CCS(=O)(=O)C1,1.9762
+130862,Please optimize the molecule CCn1nc(C)c2c1c(=O)n(Cc1ccccc1)c(=O)n2CC(N)=O to have a higher LogP value.,CCn1nc(C)c2c1c(=O)n(Cc1ccccc1)c(=O)n2CC(N)=O,0.22162000000000004
+2600,Please modify the molecule CC(C)c1noc(-c2ccc(N3CCCC[C@H]3CC(N)=O)nc2)n1 to decrease its LogP value.,CC(C)c1noc(-c2ccc(N3CCCC[C@H]3CC(N)=O)nc2)n1,2.4893
+182711,Please modify the molecule O=C(NCc1csc(C2CC2)n1)N[C@H]1C[C@H]1c1cccc(Cl)c1 to decrease its LogP value.,O=C(NCc1csc(C2CC2)n1)N[C@H]1C[C@H]1c1cccc(Cl)c1,4.029200000000003
+7251,Modify the molecule Cn1cc(C#N)c(NC(=O)C[NH+](Cc2ccccc2)Cc2ccccc2)n1 to increase its LogP value.,Cn1cc(C#N)c(NC(=O)C[NH+](Cc2ccccc2)Cc2ccccc2)n1,1.5155799999999993
+237602,Modify the molecule c1ccc(N[C@@H]2CCC[NH+](Cc3ccc(N4CCCC4)nc3)C2)cc1 to have a lower LogP value.,c1ccc(N[C@@H]2CCC[NH+](Cc3ccc(N4CCCC4)nc3)C2)cc1,2.3411999999999997
+182848,Please optimize the molecule COc1ccc(F)cc1S(=O)(=O)NCCc1c(C)[nH]c2c(Cl)cccc12 to have a higher LogP value.,COc1ccc(F)cc1S(=O)(=O)NCCc1c(C)[nH]c2c(Cl)cccc12,3.798420000000002
+171234,Optimize the molecule O=C(Nc1ccc(F)c(Cl)c1)C1CCN(C(=O)Cn2ccnc2)CC1 to have a lower LogP value.,O=C(Nc1ccc(F)c(Cl)c1)C1CCN(C(=O)Cn2ccnc2)CC1,2.552900000000001
+90042,Please optimize the molecule COc1ccc2c(C)c(CCC(=O)N[C@@H]3C[C@@H]3C)c(=O)oc2c1 to have a higher LogP value.,COc1ccc2c(C)c(CCC(=O)N[C@@H]3C[C@@H]3C)c(=O)oc2c1,2.5672200000000007
+130546,Optimize the molecule CCN1CCO[C@H](c2noc(-c3n[nH]c(N)n3)n2)C1 to have a higher LogP value.,CCN1CCO[C@H](c2noc(-c3n[nH]c(N)n3)n2)C1,-0.16990000000000055
+77549,Optimize the molecule CC1=C(C(=O)Nc2ccc(C)cc2)[C@H](c2cccc3ccccc23)n2ncnc2N1 to have a higher LogP value.,CC1=C(C(=O)Nc2ccc(C)cc2)[C@H](c2cccc3ccccc23)n2ncnc2N1,4.667320000000004
+241513,Optimize the molecule COc1ccc(F)c(CN(Cc2sccc2C)C[C@H](C)O)c1 to have a higher LogP value.,COc1ccc(F)c(CN(Cc2sccc2C)C[C@H](C)O)c1,3.587220000000003
+54193,Please optimize the molecule O=S(=O)(N1CCCC1)N1CCN(Cc2nnsc2Cl)CC1 to have a higher LogP value.,O=S(=O)(N1CCCC1)N1CCN(Cc2nnsc2Cl)CC1,0.6496999999999999
+129581,Modify the molecule C[C@@H](Oc1ccccc1[N+](=O)[O-])C(=O)Nc1ccc2ccccc2c1 to have a lower LogP value.,C[C@@H](Oc1ccccc1[N+](=O)[O-])C(=O)Nc1ccc2ccccc2c1,4.154000000000003
+183947,Optimize the molecule Cc1cscc1C(=O)Nc1cc(Cl)ccc1N to have a higher LogP value.,Cc1cscc1C(=O)Nc1cc(Cl)ccc1N,3.5444200000000015
+231778,Please modify the molecule C=C(C)[C@@H](NC)c1[nH+]ccc2ccccc12 to increase its LogP value.,C=C(C)[C@@H](NC)c1[nH+]ccc2ccccc12,2.4905
+237952,Modify the molecule O=S(=O)(NCC[C@@H](O)C1CC1)C1CC1 to decrease its LogP value.,O=S(=O)(NCC[C@@H](O)C1CC1)C1CC1,0.2291999999999994
+237926,Optimize the molecule CN(C(=O)c1cc2ccccc2s1)[C@@H]1CCC[NH+](CCc2ccccc2)C1 to have a lower LogP value.,CN(C(=O)c1cc2ccccc2s1)[C@@H]1CCC[NH+](CCc2ccccc2)C1,3.263300000000002
+108854,Modify the molecule O=C1NC(=O)C(=C/C=C/c2coc3ccccc3c2=O)C(=O)N1 to have a higher LogP value.,O=C1NC(=O)C(=C/C=C/c2coc3ccccc3c2=O)C(=O)N1,1.0985999999999998
+134536,Modify the molecule C[C@H]1C[NH+]2CCCC[C@@H]2CN1c1ncccc1CCl to decrease its LogP value.,C[C@H]1C[NH+]2CCCC[C@@H]2CN1c1ncccc1CCl,1.4662999999999997
+123943,Modify the molecule CN(C[C@@H](O)C1CC1)C(=O)[C@@H]1C[C@@H]1c1ccc(Cl)c(Cl)c1 to have a lower LogP value.,CN(C[C@@H](O)C1CC1)C(=O)[C@@H]1C[C@@H]1c1ccc(Cl)c(Cl)c1,3.326200000000002
+213925,Optimize the molecule COC(=O)[C@H](C)C[NH2+]Cc1ccccn1 to have a lower LogP value.,COC(=O)[C@H](C)C[NH2+]Cc1ccccn1,-0.04589999999999983
+150702,Please modify the molecule COC[C@@H](NC(=O)c1ccccc1C(=O)c1ccc(F)cc1)C(N)=O to increase its LogP value.,COC[C@@H](NC(=O)c1ccccc1C(=O)c1ccc(F)cc1)C(N)=O,1.2868
+1751,Please modify the molecule O=C(CCCN1C(=O)CNC1=O)N[C@H]1CCN(c2c(F)cccc2F)C1 to decrease its LogP value.,O=C(CCCN1C(=O)CNC1=O)N[C@H]1CCN(c2c(F)cccc2F)C1,0.9917000000000004
+123406,Modify the molecule NC(=O)c1ccc(NC(=O)[C@H]2CCCC[C@@H]2C(=O)OCC(F)(F)F)cc1 to have a lower LogP value.,NC(=O)c1ccc(NC(=O)[C@H]2CCCC[C@@H]2C(=O)OCC(F)(F)F)cc1,2.6359000000000004
+169355,Modify the molecule CC(C)[C@@H](Cc1ccc(F)cc1)NC(=O)C(=O)Nc1ccc(N(C)C)nc1 to decrease its LogP value.,CC(C)[C@@H](Cc1ccc(F)cc1)NC(=O)C(=O)Nc1ccc(N(C)C)nc1,2.6087000000000007
+168313,Modify the molecule CC(C)C[NH+]1CCN([C@H](C)C(=O)Nc2cccc(C#N)c2)CC1 to decrease its LogP value.,CC(C)C[NH+]1CCN([C@H](C)C(=O)Nc2cccc(C#N)c2)CC1,0.7417800000000014
+220470,Please optimize the molecule CN(C)C(=O)Cn1cc(C(=O)N[C@H]2CC[C@@H]([NH+](C)C)C2)nn1 to have a lower LogP value.,CN(C)C(=O)Cn1cc(C(=O)N[C@H]2CC[C@@H]([NH+](C)C)C2)nn1,-1.8382999999999963
+127117,Please modify the molecule CCOC(=O)c1[nH]c(C)c(C(=O)[C@@H](C)Oc2ccc(F)cc2F)c1C to increase its LogP value.,CCOC(=O)c1[nH]c(C)c(C(=O)[C@@H](C)Oc2ccc(F)cc2F)c1C,3.736640000000003
+60279,Please optimize the molecule C[C@H]1CCCC[C@]1(NC(=O)N1CCC[C@@H](C)C1)C(=O)[O-] to have a lower LogP value.,C[C@H]1CCCC[C@]1(NC(=O)N1CCC[C@@H](C)C1)C(=O)[O-],1.1267
+35576,Modify the molecule CC[C@H]1CCCCN1C(=O)[C@@H](C)OC(=O)c1cncc(C)c1 to have a higher LogP value.,CC[C@H]1CCCCN1C(=O)[C@@H](C)OC(=O)c1cncc(C)c1,2.726420000000001
+168030,Modify the molecule Cc1ccc(CNC(=O)N[C@H](C)[C@H](C)N2CCOCC2)c(N(C)C)c1 to have a higher LogP value.,Cc1ccc(CNC(=O)N[C@H](C)[C@H](C)N2CCOCC2)c(N(C)C)c1,1.9694200000000002
+196214,Modify the molecule C[C@@H](OC(=O)C(C)(C)c1cccc(Cl)c1)c1ccccn1 to increase its LogP value.,C[C@@H](OC(=O)C(C)(C)c1cccc(Cl)c1)c1ccccn1,4.317000000000004
+99413,Modify the molecule CC[C@@H](NC(=O)COc1ccc2c(c1)CCC(=O)N2)c1ccc(OC)cc1 to have a higher LogP value.,CC[C@@H](NC(=O)COc1ccc2c(c1)CCC(=O)N2)c1ccc(OC)cc1,3.2262000000000013
+22846,Please modify the molecule CCCc1nccn1-c1cccc([C@@H](C)[NH2+]CC)c1 to decrease its LogP value.,CCCc1nccn1-c1cccc([C@@H](C)[NH2+]CC)c1,2.4691
+240104,Please optimize the molecule O=C1O[C@@H](N2CCN(Cc3ccccc3)CC2)c2ccccc21 to have a lower LogP value.,O=C1O[C@@H](N2CCN(Cc3ccccc3)CC2)c2ccccc21,2.673400000000001
+111151,Please modify the molecule OCC[C@H](CNc1ncnc2cccc(F)c12)c1ccccc1 to increase its LogP value.,OCC[C@H](CNc1ncnc2cccc(F)c12)c1ccccc1,3.3470000000000013
+6074,Modify the molecule CCCCN1C(=O)S[C@H](Nc2cccc(C(F)(F)F)c2)C1=O to have a lower LogP value.,CCCCN1C(=O)S[C@H](Nc2cccc(C(F)(F)F)c2)C1=O,3.938900000000003
+145248,Please modify the molecule COc1ccc(CN2CCC[C@@H](c3cc(=O)[nH]c(-c4ccncc4)n3)C2)c(OC)c1OC to increase its LogP value.,COc1ccc(CN2CCC[C@@H](c3cc(=O)[nH]c(-c4ccncc4)n3)C2)c(OC)c1OC,3.237300000000002
+31427,Please modify the molecule O=C(Nc1ccccc1OCC(F)(F)F)c1c[nH]c2cccc(F)c12 to increase its LogP value.,O=C(Nc1ccccc1OCC(F)(F)F)c1c[nH]c2cccc(F)c12,4.500400000000002
+61135,Optimize the molecule O=C1N(Cc2ccc(Cl)cc2Cl)C[C@@H]2C[NH2+]CCN12 to have a higher LogP value.,O=C1N(Cc2ccc(Cl)cc2Cl)C[C@@H]2C[NH2+]CCN12,1.1765999999999999
+214748,Optimize the molecule Cc1onc(-c2ccccc2Cl)c1C1=NCCO1 to have a lower LogP value.,Cc1onc(-c2ccccc2Cl)c1C1=NCCO1,3.0802200000000024
+56141,Please optimize the molecule Cc1ccc([C@@H](C)NC(=O)NCc2cc[nH+]c(N3CCOCC3)c2)o1 to have a higher LogP value.,Cc1ccc([C@@H](C)NC(=O)NCc2cc[nH+]c(N3CCOCC3)c2)o1,1.7991199999999998
+13664,Modify the molecule Cc1nc(-c2ccc(OS(=O)(=O)c3ccccc3-c3ccccc3)cc2)no1 to increase its LogP value.,Cc1nc(-c2ccc(OS(=O)(=O)c3ccccc3-c3ccccc3)cc2)no1,4.479720000000004
+61683,Please modify the molecule COc1cc(CN2CCO[C@@H](c3ccc(F)c(Cl)c3)C2)c([N+](=O)[O-])cc1O to decrease its LogP value.,COc1cc(CN2CCO[C@@H](c3ccc(F)c(Cl)c3)C2)c([N+](=O)[O-])cc1O,3.675000000000003
+102439,Modify the molecule Cc1cccc(OCC[NH2+]Cc2nc3ccccc3n2C)c1 to have a higher LogP value.,Cc1cccc(OCC[NH2+]Cc2nc3ccccc3n2C)c1,2.0241199999999995
+101494,Modify the molecule CCN1C(=O)N[C@@H](c2cccc(F)c2)[C@@H]2C(=O)CC(C)(C)C[C@@]21O to have a lower LogP value.,CCN1C(=O)N[C@@H](c2cccc(F)c2)[C@@H]2C(=O)CC(C)(C)C[C@@]21O,2.6058000000000017
+83775,Optimize the molecule Cc1nc(CCC(=O)N2C[C@@H](C[NH+]3CCCCCC3)[C@@H](CO)C2)n[nH]1 to have a lower LogP value.,Cc1nc(CCC(=O)N2C[C@@H](C[NH+]3CCCCCC3)[C@@H](CO)C2)n[nH]1,-0.4284799999999968
+23276,Optimize the molecule CCc1cccc(NC(=O)CN2C(=O)C(C)(C)c3cc(S(=O)(=O)N4CCCC4)ccc32)c1 to have a higher LogP value.,CCc1cccc(NC(=O)CN2C(=O)C(C)(C)c3cc(S(=O)(=O)N4CCCC4)ccc32)c1,3.296400000000001
+49831,Please modify the molecule C[NH+](C1CCSCC1)[C@H]1CCN(c2ccccc2)C1=O to increase its LogP value.,C[NH+](C1CCSCC1)[C@H]1CCN(c2ccccc2)C1=O,1.2022
+134406,Please modify the molecule N#Cc1cc([N+](=O)[O-])ccc1N[C@@H]1CCCC[C@@H]1O to increase its LogP value.,N#Cc1cc([N+](=O)[O-])ccc1N[C@@H]1CCCC[C@@H]1O,2.181880000000001
+222861,Modify the molecule CCO[C@H]1CCCN(C(=O)NCc2ccnc(OCc3ccccc3)c2)C1 to decrease its LogP value.,CCO[C@H]1CCCN(C(=O)NCc2ccnc(OCc3ccccc3)c2)C1,3.371100000000002
+143347,Modify the molecule Cc1cnc(CN2CCc3cnc(C)nc3C2)cn1 to increase its LogP value.,Cc1cnc(CN2CCc3cnc(C)nc3C2)cn1,1.44174
+192233,Please optimize the molecule Cc1ccc(F)c(S(=O)(=O)NCc2cscn2)c1 to have a higher LogP value.,Cc1ccc(F)c(S(=O)(=O)NCc2cscn2)c1,2.06912
+178730,Please modify the molecule O=C(CSc1ccc(Cl)cc1)Nc1ccc([N+](=O)[O-])cc1N1CCOCC1 to increase its LogP value.,O=C(CSc1ccc(Cl)cc1)Nc1ccc([N+](=O)[O-])cc1N1CCOCC1,3.8156000000000025
+201929,Please optimize the molecule Cn1cc(C[NH+]2CCC[C@@H]2CC(C)(C)C)c(-c2ccncc2)n1 to have a lower LogP value.,Cn1cc(C[NH+]2CCC[C@@H]2CC(C)(C)C)c(-c2ccncc2)n1,2.4656000000000002
+12032,Please modify the molecule CCc1onc(C)c1NC(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@H](C)CC to decrease its LogP value.,CCc1onc(C)c1NC(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@H](C)CC,3.483520000000002
+87986,Modify the molecule Fc1ccc(/C=C/C[NH+]2CCC[C@@H](c3cn[nH]c3)C2)cc1 to have a higher LogP value.,Fc1ccc(/C=C/C[NH+]2CCC[C@@H](c3cn[nH]c3)C2)cc1,2.0244999999999997
+63541,Optimize the molecule C[C@@H]1C[NH+](C)CC[C@@H]1NC(=O)CCc1ccccc1 to have a lower LogP value.,C[C@@H]1C[NH+](C)CC[C@@H]1NC(=O)CCc1ccccc1,0.6585000000000012
+79907,Please modify the molecule C[C@@H](CCO)Sc1cccnn1 to increase its LogP value.,C[C@@H](CCO)Sc1cccnn1,1.3396
+75632,Optimize the molecule O=C(CNC(=O)c1ccc2sncc2c1)NCC1CCCCC1 to have a lower LogP value.,O=C(CNC(=O)c1ccc2sncc2c1)NCC1CCCCC1,2.722600000000001
+116947,Optimize the molecule CCCNC(=O)Nc1cc2c(cc1OCC)C[C@@H](C)O2 to have a higher LogP value.,CCCNC(=O)Nc1cc2c(cc1OCC)C[C@@H](C)O2,2.940200000000001
+15774,Optimize the molecule CCn1c(SCC(N)=O)nnc1-c1ccc(Cl)cc1 to have a lower LogP value.,CCn1c(SCC(N)=O)nnc1-c1ccc(Cl)cc1,2.1958
+140766,Optimize the molecule C[C@@H](CCc1ccc(O)cc1)NC(=O)N1CCN(c2ccccc2Cl)CC1 to have a lower LogP value.,C[C@@H](CCc1ccc(O)cc1)NC(=O)N1CCN(c2ccccc2Cl)CC1,3.898500000000003
+91701,Modify the molecule COc1ccc(CNS(=O)(=O)Cc2ccccc2)cc1 to have a higher LogP value.,COc1ccc(CNS(=O)(=O)Cc2ccccc2)cc1,2.3148
+37696,Modify the molecule Cc1cccc(COC(=O)Cn2c(=O)sc3cccc(Cl)c32)c1 to have a higher LogP value.,Cc1cccc(COC(=O)Cn2c(=O)sc3cccc(Cl)c32)c1,3.768220000000003
+221833,Optimize the molecule O=C1/C(=C\c2cccc(O)c2)SC(=S)N1c1cccc2ccccc12 to have a lower LogP value.,O=C1/C(=C\c2cccc(O)c2)SC(=S)N1c1cccc2ccccc12,4.951200000000003
+25906,Optimize the molecule CCOc1ccc(-n2nnc3c(=O)n(Cc4nc(-c5ccccc5Cl)no4)cnc32)cc1 to have a higher LogP value.,CCOc1ccc(-n2nnc3c(=O)n(Cc4nc(-c5ccccc5Cl)no4)cnc32)cc1,3.127600000000001
+119070,Please optimize the molecule COC[C@H](C)NC(=O)C[NH+](C)CCO to have a higher LogP value.,COC[C@H](C)NC(=O)C[NH+](C)CCO,-2.355499999999996
+210468,Please optimize the molecule Cc1ccccc1CC(=O)Nc1ccc(SCc2nc3ccccc3[nH]c2=O)cc1 to have a lower LogP value.,Cc1ccccc1CC(=O)Nc1ccc(SCc2nc3ccccc3[nH]c2=O)cc1,4.705020000000004
+192648,Please modify the molecule CC(C)(C)C(=O)NC[C@H]1CCCN(C(=O)[C@H]2SCCc3ccccc32)C1 to decrease its LogP value.,CC(C)(C)C(=O)NC[C@H]1CCCN(C(=O)[C@H]2SCCc3ccccc32)C1,3.417900000000002
+225220,Optimize the molecule COc1ccc(OC)c([C@@H]2CC(=O)NC3=NC(SC)=NC(=O)[C@@H]32)c1 to have a higher LogP value.,COc1ccc(OC)c([C@@H]2CC(=O)NC3=NC(SC)=NC(=O)[C@@H]32)c1,1.5812
+127128,Please modify the molecule CCN(C(=O)CSc1nncn1-c1ccccc1C)C1CCCCC1 to decrease its LogP value.,CCN(C(=O)CSc1nncn1-c1ccccc1C)C1CCCCC1,3.849020000000003
+125752,Modify the molecule C[NH+]1CCN(c2cc(CNC(=O)NCc3cccs3)cc[nH+]2)CC1 to decrease its LogP value.,C[NH+]1CCN(c2cc(CNC(=O)NCc3cccs3)cc[nH+]2)CC1,-0.10369999999999702
+98596,Modify the molecule Cc1ccc(NC(=O)N2CCC(c3nnc(C(=O)Nc4ccccc4)s3)CC2)cc1 to have a lower LogP value.,Cc1ccc(NC(=O)N2CCC(c3nnc(C(=O)Nc4ccccc4)s3)CC2)cc1,4.510320000000003
+180875,Please optimize the molecule CCc1ccsc1CNc1cc(F)ccc1[N+](=O)[O-] to have a higher LogP value.,CCc1ccsc1CNc1cc(F)ccc1[N+](=O)[O-],3.9699000000000026
+17345,Please modify the molecule COc1ccc([C@H]2CC(=O)C3=C(C2)OC(N)=C(C#N)[C@@H]3c2ccc(Cl)cc2)cc1 to decrease its LogP value.,COc1ccc([C@H]2CC(=O)C3=C(C2)OC(N)=C(C#N)[C@@H]3c2ccc(Cl)cc2)cc1,4.557080000000004
+13506,Please optimize the molecule CC(C)[C@@H]([NH2+][C@@H]1CSCC(C)(C)C1)C(=O)[O-] to have a lower LogP value.,CC(C)[C@@H]([NH2+][C@@H]1CSCC(C)(C)C1)C(=O)[O-],-0.14399999999999857
+188374,Please modify the molecule CCC(=O)NC(=S)NNC(=O)Cc1ccccc1 to decrease its LogP value.,CCC(=O)NC(=S)NNC(=O)Cc1ccccc1,0.6609999999999997
+22738,Please modify the molecule O=C(c1ccccc1[N+](=O)[O-])N(CCC(F)(F)F)C1CCCCC1 to increase its LogP value.,O=C(c1ccccc1[N+](=O)[O-])N(CCC(F)(F)F)C1CCCCC1,4.322100000000003
+214937,Please optimize the molecule c1ccc2c(c1)C[C@@H](CN1CCC[C@@H]1[C@@H]1CCC[NH2+]1)S2 to have a higher LogP value.,c1ccc2c(c1)C[C@@H](CN1CCC[C@@H]1[C@@H]1CCC[NH2+]1)S2,1.8936
+196215,Modify the molecule CCCCN1C[C@@H](C(=O)N(CC)CC)CC1=O to increase its LogP value.,CCCCN1C[C@@H](C(=O)N(CC)CC)CC1=O,1.5033999999999998
+85700,Optimize the molecule O=C(Cn1cnc2ccccc21)Nc1ccc(Oc2ccccc2)cc1 to have a higher LogP value.,O=C(Cn1cnc2ccccc21)Nc1ccc(Oc2ccccc2)cc1,4.4673000000000025
+216565,Optimize the molecule COc1ccc(-c2cc3nccc(-c4cc(O)ccc4O)n3n2)cc1 to have a higher LogP value.,COc1ccc(-c2cc3nccc(-c4cc(O)ccc4O)n3n2)cc1,3.483100000000002
+77547,Please optimize the molecule COc1ccc(Cl)cc1N1C[C@H](C(=O)NCc2cccs2)CC1=O to have a lower LogP value.,COc1ccc(Cl)cc1N1C[C@H](C(=O)NCc2cccs2)CC1=O,3.0794000000000006
+164850,Please optimize the molecule COc1ccccc1N(C)C(=O)c1cc2c([nH]c1=O)CCCC2 to have a lower LogP value.,COc1ccccc1N(C)C(=O)c1cc2c([nH]c1=O)CCCC2,2.538900000000001
+113915,Please optimize the molecule Cc1ccc(NC(=O)C[NH+](C)Cc2cc(C)on2)c([N+](=O)[O-])c1 to have a higher LogP value.,Cc1ccc(NC(=O)C[NH+](C)Cc2cc(C)on2)c([N+](=O)[O-])c1,0.8530400000000005
+211382,Modify the molecule CC(C)n1ccnc1[C@H](C)Br to decrease its LogP value.,CC(C)n1ccnc1[C@H](C)Br,2.919900000000001
+180700,Please modify the molecule Cc1nn([C@H]2CCS(=O)(=O)C2)c(C)c1CC(=O)Nc1nc2c(C)cccc2s1 to increase its LogP value.,Cc1nn([C@H]2CCS(=O)(=O)C2)c(C)c1CC(=O)Nc1nc2c(C)cccc2s1,2.9588600000000014
+68778,Modify the molecule Cc1c([C@@H]2C[C@H](Cl)CCO2)cnn1C to have a lower LogP value.,Cc1c([C@@H]2C[C@H](Cl)CCO2)cnn1C,2.1874199999999995
+74481,Modify the molecule Cc1cccc(CSC2=NCCN2C(=O)[C@H](C)Oc2ccccc2)c1 to have a lower LogP value.,Cc1cccc(CSC2=NCCN2C(=O)[C@H](C)Oc2ccccc2)c1,3.893920000000003
+82794,Modify the molecule CCC[C@@H](C[NH3+])[C@H](O)c1sccc1CC to have a higher LogP value.,CCC[C@@H](C[NH3+])[C@H](O)c1sccc1CC,2.0021
+209235,Please modify the molecule Nc1ccc(Br)c(N)c1Br to increase its LogP value.,Nc1ccc(Br)c(N)c1Br,2.3760000000000003
+59416,Modify the molecule O=C(NCCc1nnc(-c2ccccc2)o1)[C@@H]1CCCc2ccccc21 to have a higher LogP value.,O=C(NCCc1nnc(-c2ccccc2)o1)[C@@H]1CCCc2ccccc21,3.5154000000000023
+141486,Optimize the molecule COC(=O)Cn1/c(=N/C(=O)c2cc3ccccc3oc2=O)sc2cc(C)ccc21 to have a lower LogP value.,COC(=O)Cn1/c(=N/C(=O)c2cc3ccccc3oc2=O)sc2cc(C)ccc21,3.031720000000001
+22737,Modify the molecule COc1ccc(C(=O)N/N=C2/C(=O)N(CN3CCCC3)c3ccc(Br)cc32)cc1 to increase its LogP value.,COc1ccc(C(=O)N/N=C2/C(=O)N(CN3CCCC3)c3ccc(Br)cc32)cc1,2.9917000000000016
+145719,Modify the molecule C[C@H]1CN(C(=O)Cl)[C@H](C)CO1 to increase its LogP value.,C[C@H]1CN(C(=O)Cl)[C@H](C)CO1,1.4544000000000001
+117548,Please optimize the molecule O=C1CCN(c2cccc(Cl)c2F)C(=O)C1 to have a higher LogP value.,O=C1CCN(c2cccc(Cl)c2F)C(=O)C1,2.175
+153593,Modify the molecule CCS(=O)(=O)c1ccc(C(=O)N(Cc2ccccn2)c2nc3c(Cl)cccc3s2)cc1 to have a higher LogP value.,CCS(=O)(=O)c1ccc(C(=O)N(Cc2ccccn2)c2nc3c(Cl)cccc3s2)cc1,4.985300000000004
+70084,Modify the molecule Cc1c(NC(=O)c2ccc([N+](=O)[O-])cc2F)cccc1C(N)=O to decrease its LogP value.,Cc1c(NC(=O)c2ccc([N+](=O)[O-])cc2F)cccc1C(N)=O,2.3935199999999996
+102415,Please modify the molecule COc1cc(C[NH2+][C@H](CO)c2ccc(Cl)cc2)cc2c1OCO2 to increase its LogP value.,COc1cc(C[NH2+][C@H](CO)c2ccc(Cl)cc2)cc2c1OCO2,1.8743
+81196,Modify the molecule COc1nc(C)cc(=O)n1CCC[NH2+]C(C)C to have a lower LogP value.,COc1nc(C)cc(=O)n1CCC[NH2+]C(C)C,-0.07777999999999907
+15618,Modify the molecule O=C(NC1CCCC1)[C@H]1CCCN(C(=O)c2cc(-c3ccccn3)[nH]n2)C1 to increase its LogP value.,O=C(NC1CCCC1)[C@H]1CCCN(C(=O)c2cc(-c3ccccn3)[nH]n2)C1,2.3827
+241325,Please modify the molecule Cc1nc(-c2ccccc2)c(C(=O)N(C)Cc2nc3ccccc3[nH]2)s1 to decrease its LogP value.,Cc1nc(-c2ccccc2)c(C(=O)N(C)Cc2nc3ccccc3[nH]2)s1,4.267020000000003
+91322,Please modify the molecule O=C(CSc1cc(N2CCN(c3ccc(F)cc3)CC2)ncn1)Nc1cccc(Cl)c1Cl to increase its LogP value.,O=C(CSc1cc(N2CCN(c3ccc(F)cc3)CC2)ncn1)Nc1cccc(Cl)c1Cl,4.979900000000004
+193335,Modify the molecule C[C@H]1C[C@H](C)C[NH+](Cc2ccccc2CNC(=O)c2ccc(Cl)cc2[N+](=O)[O-])C1 to increase its LogP value.,C[C@H]1C[C@H](C)C[NH+](Cc2ccccc2CNC(=O)c2ccc(Cl)cc2[N+](=O)[O-])C1,3.2390000000000008
+114576,Please optimize the molecule Cc1cccc([C@H](O)c2cccc(C3CC3)c2)c1C to have a higher LogP value.,Cc1cccc([C@H](O)c2cccc(C3CC3)c2)c1C,4.262540000000003
+246352,Please optimize the molecule CS(=O)(=O)N1CCC[C@@H](Cc2ccnc(Cl)c2)CC1 to have a higher LogP value.,CS(=O)(=O)N1CCC[C@@H](Cc2ccnc(Cl)c2)CC1,2.3392
+99010,Optimize the molecule O=C(NCCC[NH+]1CCCCC1)N1CCCCCCC1 to have a higher LogP value.,O=C(NCCC[NH+]1CCCCC1)N1CCCCCCC1,1.4209999999999996
+183796,Optimize the molecule Cn1nc(C(=O)OCC(=O)N2CCC(c3ccccc3)=N2)c2ccccc2c1=O to have a higher LogP value.,Cn1nc(C(=O)OCC(=O)N2CCC(c3ccccc3)=N2)c2ccccc2c1=O,1.7268999999999999
+75665,Modify the molecule O=C(NC[C@H]1CN2CCCC[C@@H]2CO1)N1CCC(n2cccn2)CC1 to have a higher LogP value.,O=C(NC[C@H]1CN2CCCC[C@@H]2CO1)N1CCC(n2cccn2)CC1,1.482899999999999
+21065,Please optimize the molecule CC(=O)[C@@H]1CC[C@@H]([NH2+]C2CCC([N+](=O)[O-])CC2)[C@H]([N+](=O)[O-])C1 to have a lower LogP value.,CC(=O)[C@@H]1CC[C@@H]([NH2+]C2CCC([N+](=O)[O-])CC2)[C@H]([N+](=O)[O-])C1,0.5407000000000015
+234555,Please modify the molecule CC[C@H]1CCN(c2cc(OC)ccc2F)CC[C@H](C)[NH2+]1 to increase its LogP value.,CC[C@H]1CCN(c2cc(OC)ccc2F)CC[C@H](C)[NH2+]1,2.165
+216300,Optimize the molecule Cc1ccc(C=C2C(=O)OC3(CCCC3)OC2=O)cc1Br to have a lower LogP value.,Cc1ccc(C=C2C(=O)OC3(CCCC3)OC2=O)cc1Br,3.5112200000000025
+57559,Optimize the molecule CC(C)CC(=O)Nc1ccc(Cl)c(C(=O)N(C)C2CCOCC2)c1 to have a higher LogP value.,CC(C)CC(=O)Nc1ccc(Cl)c(C(=O)N(C)C2CCOCC2)c1,3.5756000000000023
+92009,Optimize the molecule C[C@H]1CCC[C@@](CNC(=O)C[C@H](O)c2cccc(F)c2)([NH+](C)C)C1 to have a lower LogP value.,C[C@H]1CCC[C@@](CNC(=O)C[C@H](O)c2cccc(F)c2)([NH+](C)C)C1,1.4588
+36424,Please modify the molecule Cc1ccc(Cl)c(NC(=O)C[NH+]2CCC[C@H]2C(=O)[O-])c1Cl to decrease its LogP value.,Cc1ccc(Cl)c(NC(=O)C[NH+]2CCC[C@H]2C(=O)[O-])c1Cl,0.03751999999999933
+211146,Modify the molecule CS(=O)(=O)c1cnc(-c2ccncc2)nc1[C@@H]1CCCN(C(=O)C2CCCC2)C1 to decrease its LogP value.,CS(=O)(=O)c1cnc(-c2ccncc2)nc1[C@@H]1CCCN(C(=O)C2CCCC2)C1,2.838300000000001
+8001,Please modify the molecule C=CC(=O)N[C@@H](OC)C(=O)OC to increase its LogP value.,C=CC(=O)N[C@@H](OC)C(=O)OC,-0.5659000000000001
+58157,Modify the molecule CN(C[C@H](O)CN1CC[NH+](C)CC1)C(=O)Nc1ccc([N+](=O)[O-])cc1Cl to have a lower LogP value.,CN(C[C@H](O)CN1CC[NH+](C)CC1)C(=O)Nc1ccc([N+](=O)[O-])cc1Cl,-0.09689999999999704
+231156,Please modify the molecule CC[C@@H](OC(=O)[C@@H](C)C1CCOCC1)c1cc(C)ccc1OC to decrease its LogP value.,CC[C@@H](OC(=O)[C@@H](C)C1CCOCC1)c1cc(C)ccc1OC,4.060620000000004
+93668,Optimize the molecule COC(=O)[C@@H]1C(=O)C2=C(CC1(C)C)N1CCc3ccccc3[C@@H]1CC2=O to have a lower LogP value.,COC(=O)[C@@H]1C(=O)C2=C(CC1(C)C)N1CCc3ccccc3[C@@H]1CC2=O,2.600900000000001
+134740,Optimize the molecule COCCCN1CC2(CCN(C(=O)CCn3nnnc3C)CC2)CC1=O to have a lower LogP value.,COCCCN1CC2(CCN(C(=O)CCn3nnnc3C)CC2)CC1=O,0.24922000000000133
+140138,Optimize the molecule Cc1cccc(C)c1OCC(=O)NNC(=S)NC(=O)c1ccccc1F to have a lower LogP value.,Cc1cccc(C)c1OCC(=O)NNC(=S)NC(=O)c1ccccc1F,2.1570399999999994
+59694,Please optimize the molecule C[C@@H](O)[C@@H](NC(=O)Nc1ccc(F)cc1F)C(=O)[O-] to have a higher LogP value.,C[C@@H](O)[C@@H](NC(=O)Nc1ccc(F)cc1F)C(=O)[O-],-0.4144000000000003
+124291,Modify the molecule O=C1CCC[C@H]1[C@H]1CCCC[NH+]1CCC(F)(F)F to have a higher LogP value.,O=C1CCC[C@H]1[C@H]1CCCC[NH+]1CCC(F)(F)F,1.7454
+220071,Modify the molecule CN1CCO[C@@H](C[NH+](C)C2CCC([NH3+])CC2)C1 to decrease its LogP value.,CN1CCO[C@@H](C[NH+](C)C2CCC([NH3+])CC2)C1,-1.6151999999999962
+68956,Please modify the molecule O=C(Nc1nc(-c2cc3ccccc3oc2=O)cs1)c1c[nH]c2ccccc12 to decrease its LogP value.,O=C(Nc1nc(-c2cc3ccccc3oc2=O)cs1)c1c[nH]c2ccccc12,4.650100000000003
+54825,Modify the molecule Cc1noc(C)c1CC(=O)O[C@@H](C)Cn1cccn1 to increase its LogP value.,Cc1noc(C)c1CC(=O)O[C@@H](C)Cn1cccn1,1.66234
+5756,Please optimize the molecule CN(C)c1cccc(C(=O)N(Cc2ccsc2)C2CC2)c1 to have a higher LogP value.,CN(C)c1cccc(C(=O)N(Cc2ccsc2)C2CC2)c1,3.6189000000000027
+60369,Modify the molecule COc1cc([C@@H]2CC(=O)Nc3nc(C)[nH]c(=O)c32)ccc1OCc1ccccc1F to decrease its LogP value.,COc1cc([C@@H]2CC(=O)Nc3nc(C)[nH]c(=O)c32)ccc1OCc1ccccc1F,3.2791200000000016
+189795,Optimize the molecule Cc1ccc(CCNC(=O)CC2CN(C(=O)OC(C)(C)C)C2)c(C)c1 to have a higher LogP value.,Cc1ccc(CCNC(=O)CC2CN(C(=O)OC(C)(C)C)C2)c(C)c1,3.219140000000002
+227806,Optimize the molecule COC(=O)[C@H](CCSC)NC(=O)N1CCc2[nH]c[nH+]c2[C@@H]1c1ccc(F)c(F)c1F to have a higher LogP value.,COC(=O)[C@H](CCSC)NC(=O)N1CCc2[nH]c[nH+]c2[C@@H]1c1ccc(F)c(F)c1F,2.1978999999999997
+146375,Optimize the molecule O=C(Cc1csc(NC(=O)c2ccccc2)n1)Nc1cccc(Cl)c1F to have a higher LogP value.,O=C(Cc1csc(NC(=O)c2ccccc2)n1)Nc1cccc(Cl)c1F,4.369100000000001
+184299,Please modify the molecule O=C(CCCSc1ccc(F)cc1)Nc1nnc(-c2ccc3c(c2)OCCO3)o1 to decrease its LogP value.,O=C(CCCSc1ccc(F)cc1)Nc1nnc(-c2ccc3c(c2)OCCO3)o1,4.157900000000002
+171645,Modify the molecule Cn1nc(C(=O)N2CCC[C@H](c3cccc(-c4cccc(Cl)c4)n3)C2)ccc1=O to have a higher LogP value.,Cn1nc(C(=O)N2CCC[C@H](c3cccc(-c4cccc(Cl)c4)n3)C2)ccc1=O,3.515500000000002
+130161,Optimize the molecule CCCOc1ccc2cc(C(=O)Nc3ccccc3[N+](=O)[O-])c(=O)oc2c1 to have a lower LogP value.,CCCOc1ccc2cc(C(=O)Nc3ccccc3[N+](=O)[O-])c(=O)oc2c1,3.742300000000002
+92531,Modify the molecule COC1(C[NH2+][C@@H](C)CC(=O)N(C)c2ccccc2)CCOCC1 to increase its LogP value.,COC1(C[NH2+][C@@H](C)CC(=O)N(C)c2ccccc2)CCOCC1,1.1870000000000005
+213635,Please optimize the molecule CC[C@H]1NC(=O)C[C@H](C)N(Cc2cccc(C)n2)C1=O to have a lower LogP value.,CC[C@H]1NC(=O)C[C@H](C)N(Cc2cccc(C)n2)C1=O,1.4056199999999996
+40912,Please modify the molecule CC[C@](C)(NC(=O)Nc1cc(CC(C)C)nn1C)c1nccs1 to decrease its LogP value.,CC[C@](C)(NC(=O)Nc1cc(CC(C)C)nn1C)c1nccs1,3.522000000000003
+76159,Please optimize the molecule O=C(CNC(=O)c1ccc2c(c1)OCO2)NCC1(c2ccccc2)CCCC1 to have a lower LogP value.,O=C(CNC(=O)c1ccc2c(c1)OCO2)NCC1(c2ccccc2)CCCC1,2.7733000000000008
+172480,Optimize the molecule Cc1ccc(NC(=O)c2cc3c(=O)c4ccccc4oc3o2)c(C)c1 to have a lower LogP value.,Cc1ccc(NC(=O)c2cc3c(=O)c4ccccc4oc3o2)c(C)c1,4.408340000000003
+60947,Modify the molecule Cc1nc(Cl)sc1C(=O)N1CCC(OCc2ccccc2F)CC1 to have a higher LogP value.,Cc1nc(Cl)sc1C(=O)N1CCC(OCc2ccccc2F)CC1,4.065420000000003
+191024,Modify the molecule O=C(NCCCn1cc[nH+]c1)N1CCO[C@H](c2ccc(F)c(Cl)c2)C1 to have a higher LogP value.,O=C(NCCCn1cc[nH+]c1)N1CCO[C@H](c2ccc(F)c(Cl)c2)C1,2.2679
+216405,Optimize the molecule Cc1cccc(OCc2nnc(SCCS(C)(=O)=O)o2)c1 to have a lower LogP value.,Cc1cccc(OCc2nnc(SCCS(C)(=O)=O)o2)c1,2.09372
+138691,Optimize the molecule CCc1cc(=O)[nH]c(SCC(=O)Nc2cccc(Cl)c2)n1 to have a lower LogP value.,CCc1cc(=O)[nH]c(SCC(=O)Nc2cccc(Cl)c2)n1,2.716500000000001
+171668,Please modify the molecule Cc1cc(C[NH2+]Cc2c(C)nc3sccn23)cc(C)c1F to increase its LogP value.,Cc1cc(C[NH2+]Cc2c(C)nc3sccn23)cc(C)c1F,2.7237600000000013
+9938,Please optimize the molecule O=C(N[C@H](CC(=O)N1CCC[C@H]2CCCC[C@@H]21)c1ccccc1)c1ccccc1Cl to have a lower LogP value.,O=C(N[C@H](CC(=O)N1CCC[C@H]2CCCC[C@@H]21)c1ccccc1)c1ccccc1Cl,5.382400000000006
+163135,Modify the molecule Cc1ccc2nc(COC(=O)c3ccccc3OCc3csc(C)n3)cc(=O)n2c1 to have a higher LogP value.,Cc1ccc2nc(COC(=O)c3ccccc3OCc3csc(C)n3)cc(=O)n2c1,3.7038400000000022
+220555,Optimize the molecule CCOC(=O)c1cccc(N2CCCC[C@@H](SCC)C2)n1 to have a lower LogP value.,CCOC(=O)c1cccc(N2CCCC[C@@H](SCC)C2)n1,3.370300000000002
+209361,Please optimize the molecule Nc1ccc(N2CCSC2=O)nc1 to have a lower LogP value.,Nc1ccc(N2CCSC2=O)nc1,1.337
+105945,Optimize the molecule C[NH+]1CCN(C[C@@H]2CO2)CC1 to have a lower LogP value.,C[NH+]1CCN(C[C@@H]2CO2)CC1,-1.7844999999999973
+43849,Modify the molecule C[NH+](C)C[C@@H]1C[C@H](C(C)(C)C)CCC1=O to have a lower LogP value.,C[NH+](C)C[C@@H]1C[C@H](C(C)(C)C)CCC1=O,1.1623999999999999
+148772,Optimize the molecule Cn1ccc(C(=O)NCCc2ccc3c(c2)OCO3)cc1=O to have a lower LogP value.,Cn1ccc(C(=O)NCCc2ccc3c(c2)OCO3)cc1=O,1.0864999999999998
+194647,Please modify the molecule CC(C)(C)c1cc(NC(=O)C(=O)N2CCCC2)no1 to increase its LogP value.,CC(C)(C)c1cc(NC(=O)C(=O)N2CCCC2)no1,1.533
+66529,Modify the molecule COc1ccccc1/C=C/C(=O)NC(=S)NNC(=O)c1ccccc1Br to increase its LogP value.,COc1ccccc1/C=C/C(=O)NC(=S)NNC(=O)c1ccccc1Br,2.8066000000000004
+116089,Modify the molecule CCOc1ccc(CC(=O)N[C@@H](CC)c2c(C)nn(C)c2C)cc1 to have a higher LogP value.,CCOc1ccc(CC(=O)N[C@@H](CC)c2c(C)nn(C)c2C)cc1,3.2456400000000016
+40046,Modify the molecule O=C(CC[S@@](=O)c1ccc2c(c1)OCCO2)NCCC(F)(F)F to have a higher LogP value.,O=C(CC[S@@](=O)c1ccc2c(c1)OCCO2)NCCC(F)(F)F,2.0241
+206348,Please optimize the molecule O=C(NCCC[NH2+]C1CCCCC1)Nc1cnn(-c2ccccc2F)c1 to have a lower LogP value.,O=C(NCCC[NH2+]C1CCCCC1)Nc1cnn(-c2ccccc2F)c1,2.4191000000000003
+214341,Modify the molecule Cc1cc(C)c(C(=O)N(C)CC(C)(C)C)c(C)c1 to have a lower LogP value.,Cc1cc(C)c(C(=O)N(C)CC(C)(C)C)c(C)c1,3.729960000000003
+51668,Modify the molecule Cc1nc2ccc(NC(=O)N3CCC[C@@H](C)CC3)cc2o1 to decrease its LogP value.,Cc1nc2ccc(NC(=O)N3CCC[C@@H](C)CC3)cc2o1,3.7901200000000026
+15225,Please modify the molecule CCN(CC(=O)N(C)C)C(=O)[C@@H]1CC[C@@H]2CCCC[C@@H]2[NH2+]1 to decrease its LogP value.,CCN(CC(=O)N(C)C)C(=O)[C@@H]1CC[C@@H]2CCCC[C@@H]2[NH2+]1,0.2077000000000021
+144928,Optimize the molecule CCn1c(=S)[nH]c(=O)c2c(C(=O)OC)cc(-c3ccccc3F)nc21 to have a higher LogP value.,CCn1c(=S)[nH]c(=O)c2c(C(=O)OC)cc(-c3ccccc3F)nc21,3.0666900000000012
+164006,Modify the molecule COC(=O)c1ccccc1OC(=O)c1ccsc1 to have a higher LogP value.,COC(=O)c1ccccc1OC(=O)c1ccsc1,2.7539000000000016
+95432,Optimize the molecule CCOc1ccc(NC(=O)NCCCN2CCOCC2)cc1F to have a higher LogP value.,CCOc1ccc(NC(=O)NCCCN2CCOCC2)cc1F,2.0681999999999996
+141385,Optimize the molecule Cc1ccc2cccc(NC(=O)[C@@H](C)SCc3nc4scc(-c5ccccc5)c4c(=O)[nH]3)c2n1 to have a higher LogP value.,Cc1ccc2cccc(NC(=O)[C@@H](C)SCc3nc4scc(-c5ccccc5)c4c(=O)[nH]3)c2n1,5.768620000000005
+41774,Optimize the molecule CC(C)[C@]1(O)CN(S(=O)(=O)c2ccc3c(c2)CCC(=O)N3)C[C@H]1C to have a lower LogP value.,CC(C)[C@]1(O)CN(S(=O)(=O)c2ccc3c(c2)CCC(=O)N3)C[C@H]1C,1.5988000000000002
+87612,Please modify the molecule C/C(=N\N[C@@H]1N=CN=N1)c1ccc(Cl)c(Cl)c1 to decrease its LogP value.,C/C(=N\N[C@@H]1N=CN=N1)c1ccc(Cl)c(Cl)c1,3.0847000000000016
+24658,Modify the molecule COc1cc(NS(C)(=O)=O)c(OC)cc1Cl to increase its LogP value.,COc1cc(NS(C)(=O)=O)c(OC)cc1Cl,1.7287
+195458,Modify the molecule CCNC(=O)N1CCN(Cc2csc(-c3ccc(Cl)cc3)n2)CC1 to have a higher LogP value.,CCNC(=O)N1CCN(Cc2csc(-c3ccc(Cl)cc3)n2)CC1,3.3106000000000018
+196808,Optimize the molecule O=C([O-])c1ccccc1C(=O)N1CCS[C@H]1c1ccccc1 to have a lower LogP value.,O=C([O-])c1ccccc1C(=O)N1CCS[C@H]1c1ccccc1,1.9379
+66708,Modify the molecule Cc1ccc(/C=C/C(=O)N2CCN(Cc3cccnc3)CC2)cc1Cl to have a higher LogP value.,Cc1ccc(/C=C/C(=O)N2CCN(Cc3cccnc3)CC2)cc1Cl,3.4010200000000026
+213589,Optimize the molecule Cc1noc(C)c1S(=O)(=O)NNC(=O)CC12CC3CC(CC(C3)C1)C2 to have a lower LogP value.,Cc1noc(C)c1S(=O)(=O)NNC(=O)CC12CC3CC(CC(C3)C1)C2,2.207439999999999
+49679,Modify the molecule COc1ccccc1[C@H](NC(=O)NCc1ccccn1)c1ccccn1 to have a higher LogP value.,COc1ccccc1[C@H](NC(=O)NCc1ccccn1)c1ccccn1,3.0740000000000016
+9655,Please modify the molecule CC[C@H]([NH2+][C@@H]1CCCC1(C)C)c1ccc(C)cc1 to increase its LogP value.,CC[C@H]([NH2+][C@@H]1CCCC1(C)C)c1ccc(C)cc1,3.5882200000000024
+123027,Modify the molecule CC(C)CCO[C@@H]1CCCC[C@@H]1NC(=O)c1nccn2ccnc12 to have a lower LogP value.,CC(C)CCO[C@@H]1CCCC[C@@H]1NC(=O)c1nccn2ccnc12,2.833000000000001
+122084,Optimize the molecule Cc1cccc(OCCNC(=O)COc2ccc3c(C)cc(=O)oc3c2)c1 to have a lower LogP value.,Cc1cccc(OCCNC(=O)COc2ccc3c(C)cc(=O)oc3c2)c1,2.9838400000000007
+242460,Please optimize the molecule CS(=O)(=O)c1ccc(SCCCCS)cc1 to have a higher LogP value.,CS(=O)(=O)c1ccc(SCCCCS)cc1,2.8922000000000017
+53602,Optimize the molecule CCCCN1C(=O)c2ccc(C(=O)Nc3ccc(-n4cnnn4)cc3)cc2C1=O to have a higher LogP value.,CCCCN1C(=O)c2ccc(C(=O)Nc3ccc(-n4cnnn4)cc3)cc2C1=O,2.3106999999999998
+21276,Modify the molecule Cc1nn(CCO)c(C)c1C[NH+]1CCC(CC[NH+](C)C)CC1 to have a higher LogP value.,Cc1nn(CCO)c(C)c1C[NH+]1CCC(CC[NH+](C)C)CC1,-1.1782599999999943
+61340,Modify the molecule COCc1cccc(C(=O)Nc2cc(C)nn2-c2ccc(C)nn2)c1 to have a higher LogP value.,COCc1cccc(C(=O)Nc2cc(C)nn2-c2ccc(C)nn2)c1,2.6778400000000007
+90190,Modify the molecule Cc1[nH]n(-c2nc(-c3ccccc3)cs2)c(=O)c1[C@@H](c1ccccc1)[C@@H](C#N)C(N)=O to decrease its LogP value.,Cc1[nH]n(-c2nc(-c3ccccc3)cs2)c(=O)c1[C@@H](c1ccccc1)[C@@H](C#N)C(N)=O,3.3545000000000016
+166520,Please modify the molecule NC(=S)c1[nH+]ccn1CC(=O)Nc1ccc(Br)cc1 to decrease its LogP value.,NC(=S)c1[nH+]ccn1CC(=O)Nc1ccc(Br)cc1,1.3375999999999997
+118480,Modify the molecule O=C([C@H]1CC(=O)N(c2cccc(F)c2)C1)N1CCCCC1 to increase its LogP value.,O=C([C@H]1CC(=O)N(c2cccc(F)c2)C1)N1CCCCC1,2.1911000000000005
+174379,Modify the molecule O=C(COc1ccccc1)Nc1nc(-c2ccc(Br)cc2)ns1 to increase its LogP value.,O=C(COc1ccccc1)Nc1nc(-c2ccc(Br)cc2)ns1,3.985100000000002
+52819,Optimize the molecule N#Cc1ccc(Cl)c(NC(=O)NCCCCn2ccccc2=O)c1 to have a lower LogP value.,N#Cc1ccc(Cl)c(NC(=O)NCCCCn2ccccc2=O)c1,2.9752800000000015
+179095,Modify the molecule COc1cccc([C@H]2NC(=O)NC(C)=C2C(=O)OCCC#N)c1 to decrease its LogP value.,COc1cccc([C@H]2NC(=O)NC(C)=C2C(=O)OCCC#N)c1,1.77998
+133740,Please optimize the molecule Cc1nc2ccccc2c(=O)n1N[C@@H](O)C(Cl)(Cl)Cl to have a lower LogP value.,Cc1nc2ccccc2c(=O)n1N[C@@H](O)C(Cl)(Cl)Cl,1.93702
+149637,Please modify the molecule COc1ccc(NC(=O)COc2ccc(C)cc2-n2cnnc2)cc1OC to decrease its LogP value.,COc1ccc(NC(=O)COc2ccc(C)cc2-n2cnnc2)cc1OC,2.6104200000000004
+213870,Please modify the molecule O=C1CC[C@H](COC(=O)c2cccc(Br)c2)N1 to increase its LogP value.,O=C1CC[C@H](COC(=O)c2cccc(Br)c2)N1,1.8844999999999998
+9689,Please modify the molecule CC(=O)c1cc(F)c(C)cc1N1CCO[C@H](C)C1 to increase its LogP value.,CC(=O)c1cc(F)c(C)cc1N1CCO[C@H](C)C1,2.561820000000001
+215148,Modify the molecule COCCn1nc(C)c(CNC(=O)N[C@@H]2CCC[C@H]2C(N)=O)c1C to increase its LogP value.,COCCn1nc(C)c(CNC(=O)N[C@@H]2CCC[C@H]2C(N)=O)c1C,0.5995400000000014
+56806,Optimize the molecule C[C@H]1Cc2ccc(CNC(=O)CSCc3ccc(F)cc3)cc2N1C(=O)c1ccccc1 to have a lower LogP value.,C[C@H]1Cc2ccc(CNC(=O)CSCc3ccc(F)cc3)cc2N1C(=O)c1ccccc1,4.966700000000005
+31911,Modify the molecule Cc1cc(C)c2oc(=O)n(C3CCN(C(=O)c4ccc(C#N)cc4)CC3)c2c1 to have a higher LogP value.,Cc1cc(C)c2oc(=O)n(C3CCN(C(=O)c4ccc(C#N)cc4)CC3)c2c1,3.5603200000000026
+22748,Modify the molecule Cc1cccc(-c2nnc([S-])n2CC(=O)NCc2ccccc2CN2C[C@H](C)O[C@@H](C)C2)c1 to decrease its LogP value.,Cc1cccc(-c2nnc([S-])n2CC(=O)NCc2ccccc2CN2C[C@H](C)O[C@@H](C)C2)c1,3.084920000000001
+7891,Optimize the molecule O=C(Nc1ccccc1C(=O)NCc1ccco1)C1=CCCCO1 to have a lower LogP value.,O=C(Nc1ccccc1C(=O)NCc1ccco1)C1=CCCCO1,2.8424000000000014
+207235,Optimize the molecule CC[C@H](NC(=O)NCc1ccc(C)cc1OC(C)(C)C)c1nccs1 to have a higher LogP value.,CC[C@H](NC(=O)NCc1ccc(C)cc1OC(C)(C)C)c1nccs1,4.579320000000004
+134022,Modify the molecule Cc1nn(CN2CCO[C@@H](C(N)=O)C2)c(C)c1Br to have a higher LogP value.,Cc1nn(CN2CCO[C@@H](C(N)=O)C2)c(C)c1Br,0.40603999999999985
+97354,Modify the molecule N#Cc1cccc(OS(=O)(=O)c2ccc([N+](=O)[O-])cc2F)c1 to have a higher LogP value.,N#Cc1cccc(OS(=O)(=O)c2ccc([N+](=O)[O-])cc2F)c1,2.3732800000000003
+179382,Please optimize the molecule COCc1cc(NC(=O)C(=O)NCCc2ccc(Cl)cc2)ncn1 to have a lower LogP value.,COCc1cc(NC(=O)C(=O)NCCc2ccc(Cl)cc2)ncn1,1.5737999999999999
+196992,Please modify the molecule CC[NH2+][C@H](C)[C@H]1CCC[NH+](C(CC)CC)C1 to increase its LogP value.,CC[NH2+][C@H](C)[C@H]1CCC[NH+](C(CC)CC)C1,0.441700000000002
+217225,Please modify the molecule Cn1ccc(C(=O)N[C@@H]2CCCN(Cc3ccccc3)C2=O)c1 to increase its LogP value.,Cn1ccc(C(=O)N[C@@H]2CCCN(Cc3ccccc3)C2=O)c1,1.9461
+3565,Modify the molecule [NH3+][C@H](C(=O)[O-])[C@H](O)c1ccc(F)cc1 to decrease its LogP value.,[NH3+][C@H](C(=O)[O-])[C@H](O)c1ccc(F)cc1,-1.7804999999999995
+156539,Modify the molecule COc1ccc(CN2C[C@H](C)OCC2(C)C)cc1 to decrease its LogP value.,COc1ccc(CN2C[C@H](C)OCC2(C)C)cc1,2.6945000000000006
+177417,Optimize the molecule O=C(Cc1noc(-c2csc([N+](=O)[O-])c2)n1)NCc1ccccc1 to have a higher LogP value.,O=C(Cc1noc(-c2csc([N+](=O)[O-])c2)n1)NCc1ccccc1,2.565200000000001
+172617,Optimize the molecule O=C(NCCCOc1cccc2cccnc12)c1cc2ccccc2oc1=O to have a lower LogP value.,O=C(NCCCOc1cccc2cccnc12)c1cc2ccccc2oc1=O,3.5401000000000025
+248384,Modify the molecule CC(=O)c1ccc(NC(=O)N[C@H]2[C@@H]3CCO[C@@H]3C23CCC3)cc1C to have a higher LogP value.,CC(=O)c1ccc(NC(=O)N[C@H]2[C@@H]3CCO[C@@H]3C23CCC3)cc1C,3.276720000000002
+138763,Please modify the molecule CCc1ccc2c(c1)C(c1cccs1)=NNC(c1cccnc1)=N2 to increase its LogP value.,CCc1ccc2c(c1)C(c1cccs1)=NNC(c1cccnc1)=N2,4.139400000000003
+10063,Please optimize the molecule CCC[C@@H]1CN(Cc2cc(Cl)ccc2[N+](=O)[O-])CC[NH2+]1 to have a lower LogP value.,CCC[C@@H]1CN(Cc2cc(Cl)ccc2[N+](=O)[O-])CC[NH2+]1,1.7959
+241619,Modify the molecule C[C@H](CNC(=O)Cn1cnc2ccc(F)cc2c1=O)Cn1cccn1 to increase its LogP value.,C[C@H](CNC(=O)Cn1cnc2ccc(F)cc2c1=O)Cn1cccn1,1.1845999999999992
+176807,Please modify the molecule CNC(=O)c1ccc(/C=C/C(=O)NC[C@@H](OC)c2ccccc2)cc1 to increase its LogP value.,CNC(=O)c1ccc(/C=C/C(=O)NC[C@@H](OC)c2ccccc2)cc1,2.563300000000001
+219650,Modify the molecule COc1cccc(OC)c1C(=O)NCC[NH+]1CCN(c2ccc(F)cc2)CC1 to increase its LogP value.,COc1cccc(OC)c1C(=O)NCC[NH+]1CCN(c2ccc(F)cc2)CC1,0.9778000000000009
+94616,Please optimize the molecule CN1C(=O)C[C@H](NC(=O)C2([NH+](C)C)CCC2)[C@@H]1c1ccc(Cl)cc1 to have a higher LogP value.,CN1C(=O)C[C@H](NC(=O)C2([NH+](C)C)CCC2)[C@@H]1c1ccc(Cl)cc1,0.7952000000000012
+17046,Please optimize the molecule N#CCCCC(=O)c1ccccc1I to have a lower LogP value.,N#CCCCC(=O)c1ccccc1I,3.1677800000000023
+49317,Please modify the molecule CC[NH+](Cc1cc(Br)ccc1O)[C@H](C)c1nnc(C)o1 to increase its LogP value.,CC[NH+](Cc1cc(Br)ccc1O)[C@H](C)c1nnc(C)o1,2.01212
+31212,Modify the molecule COc1cc2c(c(OC)c1OC)[C@@H](c1ccc(Br)cc1)CC(=O)N2 to increase its LogP value.,COc1cc2c(c(OC)c1OC)[C@@H](c1ccc(Br)cc1)CC(=O)N2,3.9490000000000025
+125734,Please modify the molecule CC(C)/C(=C\C1CCCC1)CBr to decrease its LogP value.,CC(C)/C(=C\C1CCCC1)CBr,4.153900000000004
+193899,Optimize the molecule CCC[C@H](NC(=O)CSc1nc2ccccc2n(C)c1=O)c1cccs1 to have a higher LogP value.,CCC[C@H](NC(=O)CSc1nc2ccccc2n(C)c1=O)c1cccs1,3.7447000000000026
+229186,Modify the molecule CC(=O)N1CCCc2cc(S(=O)(=O)NCc3ccc(OC(C)C)cc3)ccc21 to increase its LogP value.,CC(=O)N1CCCc2cc(S(=O)(=O)NCc3ccc(OC(C)C)cc3)ccc21,3.251400000000002
+51582,Please optimize the molecule CC[NH+](CC)CCNc1cc(OC)cc2nccnc12 to have a higher LogP value.,CC[NH+](CC)CCNc1cc(OC)cc2nccnc12,0.9750000000000003
+16742,Modify the molecule CCOc1ccc(NC(=O)CN(c2cccc(F)c2)S(C)(=O)=O)cc1 to have a higher LogP value.,CCOc1ccc(NC(=O)CN(c2cccc(F)c2)S(C)(=O)=O)cc1,2.629100000000001
+213955,Modify the molecule [NH3+]C1CCC(OC(=O)Nc2ccc(F)cc2)CC1 to have a higher LogP value.,[NH3+]C1CCC(OC(=O)Nc2ccc(F)cc2)CC1,1.9272999999999993
+171503,Modify the molecule CON(C)C(=O)CN(C)[C@H]1CCCN(c2ccccc2)C1 to decrease its LogP value.,CON(C)C(=O)CN(C)[C@H]1CCCN(c2ccccc2)C1,1.6069999999999989
+224715,Modify the molecule CCOc1ccc(N(C)S(=O)(=O)Cc2cccc(C#N)c2)cc1 to increase its LogP value.,CCOc1ccc(N(C)S(=O)(=O)Cc2cccc(C#N)c2)cc1,2.923180000000001
+186638,Optimize the molecule O=C(NCc1cccc2cccnc12)c1csc(-c2ccco2)n1 to have a lower LogP value.,O=C(NCc1cccc2cccnc12)c1csc(-c2ccco2)n1,3.881300000000003
+214780,Modify the molecule CCn1cc(C[NH2+]Cc2ccc(OC)cc2OC)cn1 to have a lower LogP value.,CCn1cc(C[NH2+]Cc2ccc(OC)cc2OC)cn1,1.183799999999999
+168131,Optimize the molecule Cc1csc(NC(=O)c2sc(-c3ccccc3F)nc2C)n1 to have a higher LogP value.,Cc1csc(NC(=O)c2sc(-c3ccccc3F)nc2C)n1,4.274840000000003
+31676,Please modify the molecule CC(C)Cn1ccnc(Oc2ccc(OCC(N)=O)cc2)c1=O to decrease its LogP value.,CC(C)Cn1ccnc(Oc2ccc(OCC(N)=O)cc2)c1=O,1.5556999999999999
+91319,Modify the molecule CC(C)(C)C[NH+](CCC#N)Cc1nc(-c2cccc(Br)c2)no1 to decrease its LogP value.,CC(C)(C)C[NH+](CCC#N)Cc1nc(-c2cccc(Br)c2)no1,2.8437800000000015
+148032,Modify the molecule CN(C)c1ccc(/C=C(/C#N)C(N)=O)cc1 to have a lower LogP value.,CN(C)c1ccc(/C=C(/C#N)C(N)=O)cc1,1.14488
+138843,Modify the molecule Cc1ccn2nc(N[C@@H](C)c3cccs3)nc2c1 to have a higher LogP value.,Cc1ccn2nc(N[C@@H](C)c3cccs3)nc2c1,3.2723200000000014
+89029,Please modify the molecule COc1ccc(-n2nc(C(=O)Oc3c(F)cccc3OC)cc2C)cc1 to increase its LogP value.,COc1ccc(-n2nc(C(=O)Oc3c(F)cccc3OC)cc2C)cc1,3.5562200000000024
+132729,Modify the molecule COc1ccc2cccc(CC(=O)N[C@@H]3CCCc4cn[nH]c43)c2c1 to increase its LogP value.,COc1ccc2cccc(CC(=O)N[C@@H]3CCCc4cn[nH]c43)c2c1,3.307800000000001
+226936,Modify the molecule CCc1nnc(SCCC(=O)Nc2ccc(C)cc2)n1-c1ccccc1 to have a lower LogP value.,CCc1nnc(SCCC(=O)Nc2ccc(C)cc2)n1-c1ccccc1,4.259020000000003
+32370,Please modify the molecule COc1ccc(OC)c2[nH]c(C(F)(F)F)nc12 to decrease its LogP value.,COc1ccc(OC)c2[nH]c(C(F)(F)F)nc12,2.5989000000000004
+56914,Please optimize the molecule C[S@](=O)CCNC(=O)Nc1cc(-c2ccccc2)on1 to have a lower LogP value.,C[S@](=O)CCNC(=O)Nc1cc(-c2ccccc2)on1,1.8415999999999995
+59612,Please optimize the molecule C[C@@H]1CN(Cc2ccccc2CNC(=O)c2cccc3cn[nH]c23)C[C@@H](C)O1 to have a lower LogP value.,C[C@@H]1CN(Cc2ccccc2CNC(=O)c2cccc3cn[nH]c23)C[C@@H](C)O1,3.102100000000001
+97640,Modify the molecule CCC(=O)N1CCN(c2cc(C)cc(C)c2)C(=O)[C@@H]1C to have a higher LogP value.,CCC(=O)N1CCN(c2cc(C)cc(C)c2)C(=O)[C@@H]1C,2.27714
+202381,Please modify the molecule COCc1ccccc1C(=O)N1CCC[C@@H](c2nc(C)cs2)C1 to increase its LogP value.,COCc1ccccc1C(=O)N1CCC[C@@H](c2nc(C)cs2)C1,3.617720000000003
+74820,Modify the molecule CC[C@H](C)NS(=O)(=O)c1ccc(NC=C2C(=O)CC(C)(C)CC2=O)cc1 to decrease its LogP value.,CC[C@H](C)NS(=O)(=O)c1ccc(NC=C2C(=O)CC(C)(C)CC2=O)cc1,3.017400000000001
+189845,Please modify the molecule CC(C)OC(=O)C1=C(N)Oc2c(c(=O)sc3ccccc23)[C@H]1c1cccnc1 to increase its LogP value.,CC(C)OC(=O)C1=C(N)Oc2c(c(=O)sc3ccccc23)[C@H]1c1cccnc1,3.3027000000000015
+242747,Please optimize the molecule C[C@H]1CCC[C@@H]([NH+]2CCN(C(=O)c3cccc(Cl)c3)CC2)C1 to have a lower LogP value.,C[C@H]1CCC[C@@H]([NH+]2CCN(C(=O)c3cccc(Cl)c3)CC2)C1,2.2594000000000003
+196372,Modify the molecule C[C@H](Sc1nnc(C2CC2)n1C)C(=O)Nc1c(F)cccc1F to increase its LogP value.,C[C@H](Sc1nnc(C2CC2)n1C)C(=O)Nc1c(F)cccc1F,3.0900000000000016
+5953,Please modify the molecule O=C(c1ccc(Cn2c(=O)[nH]c3ccccc3c2=O)cc1)N1CCN(c2ccccc2)CC1 to decrease its LogP value.,O=C(c1ccc(Cn2c(=O)[nH]c3ccccc3c2=O)cc1)N1CCN(c2ccccc2)CC1,2.700500000000001
+244602,Please optimize the molecule COc1ccc(Br)cc1[C@@H]1CC(=O)N2CN(c3ccc(Cl)cc3)CSC2=C1C#N to have a higher LogP value.,COc1ccc(Br)cc1[C@@H]1CC(=O)N2CN(c3ccc(Cl)cc3)CSC2=C1C#N,5.330580000000003
+82239,Modify the molecule CC[S@](=O)[C@H]1CCCC[C@@H]1NC(=O)C(=O)Nc1cccc(C(C)C)c1 to increase its LogP value.,CC[S@](=O)[C@H]1CCCC[C@@H]1NC(=O)C(=O)Nc1cccc(C(C)C)c1,2.9445000000000006
+48077,Please optimize the molecule CCC[C@H](C)NC(=O)[C@H](C)N1CCN(C(=O)c2ccco2)CC1 to have a higher LogP value.,CCC[C@H](C)NC(=O)[C@H](C)N1CCN(C(=O)c2ccco2)CC1,1.7306999999999997