diff --git "a/benchmarks/open_generation/MolEdit/DelComponent/test.csv" "b/benchmarks/open_generation/MolEdit/DelComponent/test.csv"
new file mode 100644--- /dev/null
+++ "b/benchmarks/open_generation/MolEdit/DelComponent/test.csv"
@@ -0,0 +1,5001 @@
+index,Instruction,molecule,removed_group
+26974,Please remove a benzene_ring from the molecule O=C(Cc1ccc(Cl)cc1)NC[C@](O)(c1ccccc1)C(F)(F)F.,O=C(Cc1ccc(Cl)cc1)NC[C@](O)(c1ccccc1)C(F)(F)F,benzene_ring
+75570,Please remove a amide from the molecule O=C(C[NH+]1C[C@H]2CC=CC[C@H]2C1)NOCc1ccccc1.,O=C(C[NH+]1C[C@H]2CC=CC[C@H]2C1)NOCc1ccccc1,amide
+102138,Please remove a amide from the molecule COC(=O)c1c(C)[nH]c(C(=O)NC2=NCCS2)c1C.,COC(=O)c1c(C)[nH]c(C(=O)NC2=NCCS2)c1C,amide
+218964,Please remove a halo from the molecule C[C@H](Oc1ccc([N+](=O)[O-])cc1F)C(=O)[O-].,C[C@H](Oc1ccc([N+](=O)[O-])cc1F)C(=O)[O-],halo
+54266,Remove a amine from the molecule CCCN/C(N)=[NH+]/CC[C@@H](C)SC.,CCCN/C(N)=[NH+]/CC[C@@H](C)SC,amine
+226306,Please remove a halo from the molecule Ic1ncn(C2CCCC2)n1.,Ic1ncn(C2CCCC2)n1,halo
+116785,Please remove a benzene_ring from the molecule CC[C@H](C)Oc1ccc(NC(=O)/C=C/C(=O)[O-])cc1.,CC[C@H](C)Oc1ccc(NC(=O)/C=C/C(=O)[O-])cc1,benzene_ring
+129774,Please remove a benzene_ring from the molecule C[C@H]1COC[C@H](C)N1C(=O)c1cc(F)c(F)cc1Cl.,C[C@H]1COC[C@H](C)N1C(=O)c1cc(F)c(F)cc1Cl,benzene_ring
+4647,Remove a halo from the molecule O=C(NCCCc1n[nH]c(=O)[nH]1)[C@H]1C[C@@H]1c1c(F)cccc1F.,O=C(NCCCc1n[nH]c(=O)[nH]1)[C@H]1C[C@@H]1c1c(F)cccc1F,halo
+241035,Remove a benzene_ring from the molecule O=C([C@@H](O)c1ccccc1)N1CCN(c2ncc(Cl)cc2Cl)CC1.,O=C([C@@H](O)c1ccccc1)N1CCN(c2ncc(Cl)cc2Cl)CC1,benzene_ring
+80945,Remove a benzene_ring from the molecule CO[C@@H](C)C(=O)O[C@H](C)c1ccc(C)c([N+](=O)[O-])c1.,CO[C@@H](C)C(=O)O[C@H](C)c1ccc(C)c([N+](=O)[O-])c1,benzene_ring
+113549,Please remove a amide from the molecule COc1cccc(-c2cc(C3(C(=O)NC4CC[NH+](Cc5ccccc5)CC4)CC3)no2)c1.,COc1cccc(-c2cc(C3(C(=O)NC4CC[NH+](Cc5ccccc5)CC4)CC3)no2)c1,amide
+205850,Remove a halo from the molecule O=C(C1CCC1)N1C[C@@H]2CC[C@H](C1)N(C(=O)c1cc(Cl)ccc1O)C2.,O=C(C1CCC1)N1C[C@@H]2CC[C@H](C1)N(C(=O)c1cc(Cl)ccc1O)C2,halo
+95101,Please remove a amide from the molecule CCOc1ccccc1N1C[C@H](C(=O)NC)CC1=O.,CCOc1ccccc1N1C[C@H](C(=O)NC)CC1=O,amide
+239829,Remove a amide from the molecule COCCn1ccc2ccc(NC(=O)c3ncccc3OC(C)C)cc21.,COCCn1ccc2ccc(NC(=O)c3ncccc3OC(C)C)cc21,amide
+89230,Modify the molecule O=C(Cn1nc(-c2ccccc2F)ccc1=O)c1ccc(Cl)s1 by removing a halo.,O=C(Cn1nc(-c2ccccc2F)ccc1=O)c1ccc(Cl)s1,halo
+111718,Please remove a amide from the molecule CCC(C)(C)NC(=O)c1ccc(NC(=O)C(=O)NCC2CCC2)cc1.,CCC(C)(C)NC(=O)c1ccc(NC(=O)C(=O)NCC2CCC2)cc1,amide
+126892,Modify the molecule CCOc1ccc(NC(=O)Cc2csc(NC(=O)C3CC3)n2)cc1 by removing a benzene_ring.,CCOc1ccc(NC(=O)Cc2csc(NC(=O)C3CC3)n2)cc1,benzene_ring
+244370,Please remove a benzene_ring from the molecule O=C(NC(=S)Nc1cccc(N2CCCC2)c1)c1ccc(Br)cc1.,O=C(NC(=S)Nc1cccc(N2CCCC2)c1)c1ccc(Br)cc1,benzene_ring
+124586,Please remove a nitro from the molecule [NH3+]C[C@@H]1CCC[C@@H]1COCc1cc(Cl)ccc1[N+](=O)[O-].,[NH3+]C[C@@H]1CCC[C@@H]1COCc1cc(Cl)ccc1[N+](=O)[O-],nitro
+131953,Modify the molecule COc1cccc([C@@H]2C(C#N)=C(N)N(N(C)C)C3=C2C(=O)C[C@@H](c2ccccc2)C3)c1 by removing a amine.,COc1cccc([C@@H]2C(C#N)=C(N)N(N(C)C)C3=C2C(=O)C[C@@H](c2ccccc2)C3)c1,amine
+145253,Please remove a halo from the molecule CCC[C@H](C[NH3+])[C@@H](O)c1cc(Cl)c2c(c1)OCCCO2.,CCC[C@H](C[NH3+])[C@@H](O)c1cc(Cl)c2c(c1)OCCCO2,halo
+181034,Remove a hydroxyl from the molecule CC(C)[C@H](O)[C@@H](c1ccccc1O)n1nnc2ccccc21.,CC(C)[C@H](O)[C@@H](c1ccccc1O)n1nnc2ccccc21,hydroxyl
+111420,Modify the molecule COc1ccc(NC(=O)[C@@H]2CCC[NH+]2Cc2cc(-c3ccccc3)[nH]n2)cc1 by removing a benzene_ring.,COc1ccc(NC(=O)[C@@H]2CCC[NH+]2Cc2cc(-c3ccccc3)[nH]n2)cc1,benzene_ring
+209834,Remove a benzene_ring from the molecule COC(=O)c1cccc(SCCS(=O)(=O)c2ccc(C)cc2)c1.,COC(=O)c1cccc(SCCS(=O)(=O)c2ccc(C)cc2)c1,benzene_ring
+248810,Remove a amine from the molecule N/C([S-])=[NH+]/Nc1ccc(Cl)c(Cl)c1.,N/C([S-])=[NH+]/Nc1ccc(Cl)c(Cl)c1,amine
+117862,Remove a amide from the molecule C=CCCC[C@H](C)[NH+]1CCN(C(=O)Cc2c(C)noc2C)CC1.,C=CCCC[C@H](C)[NH+]1CCN(C(=O)Cc2c(C)noc2C)CC1,amide
+101109,Remove a amide from the molecule COCCNC(=O)NC(=O)CNc1cccc(F)c1C.,COCCNC(=O)NC(=O)CNc1cccc(F)c1C,amide
+54679,Please remove a benzene_ring from the molecule Cc1nn(Cc2c(Cl)cccc2Cl)c2sc(C(=O)OCc3ncon3)cc12.,Cc1nn(Cc2c(Cl)cccc2Cl)c2sc(C(=O)OCc3ncon3)cc12,benzene_ring
+167518,Modify the molecule O=C([O-])CC1(NC(=O)CC2C[C@@H]3CC[C@H](C2)[NH2+]3)CCC1 by removing a amide.,O=C([O-])CC1(NC(=O)CC2C[C@@H]3CC[C@H](C2)[NH2+]3)CCC1,amide
+211139,Please remove a amide from the molecule CC(C)NC(=O)c1cc([C@@H]2CN(C(=O)c3ccncc3)CCO2)nc2ccccc12.,CC(C)NC(=O)c1cc([C@@H]2CN(C(=O)c3ccncc3)CCO2)nc2ccccc12,amide
+6656,Modify the molecule O=C(OCc1cc(-c2ccccc2)on1)c1ccc(F)cc1 by removing a benzene_ring.,O=C(OCc1cc(-c2ccccc2)on1)c1ccc(F)cc1,benzene_ring
+194868,Modify the molecule CCS(=O)(=O)CCNC(=O)C1(c2cccc(C)c2)CCCC1 by removing a amide.,CCS(=O)(=O)CCNC(=O)C1(c2cccc(C)c2)CCCC1,amide
+47089,Modify the molecule C[C@H](Sc1nccn1-c1cccc(F)c1)C(=O)Nc1ccc2c(c1)OCCO2 by removing a halo.,C[C@H](Sc1nccn1-c1cccc(F)c1)C(=O)Nc1ccc2c(c1)OCCO2,halo
+112161,Modify the molecule CC(C)N1C(=O)C[C@@H]([NH+]2CC[C@H](C(=O)[O-])[C@@H]2C)C1=O by removing a amide.,CC(C)N1C(=O)C[C@@H]([NH+]2CC[C@H](C(=O)[O-])[C@@H]2C)C1=O,amide
+221214,Please remove a amide from the molecule CCc1c(C)sc2nc(S[C@H](C)C(=O)N3CCCC[C@@H]3CC)n(C[C@@H]3CCCO3)c(=O)c12.,CCc1c(C)sc2nc(S[C@H](C)C(=O)N3CCCC[C@@H]3CC)n(C[C@@H]3CCCO3)c(=O)c12,amide
+220385,Remove a amide from the molecule CCOc1ccc(NC(=O)c2sc3nc(C)nc(N4CCC(C)CC4)c3c2C)cc1.,CCOc1ccc(NC(=O)c2sc3nc(C)nc(N4CCC(C)CC4)c3c2C)cc1,amide
+163069,Remove a benzene_ring from the molecule C[C@@H](CCc1ccc(O)cc1)NC(=O)N1CCc2ccccc21.,C[C@@H](CCc1ccc(O)cc1)NC(=O)N1CCc2ccccc21,benzene_ring
+99508,Please remove a amine from the molecule C[NH+]1[C@H]2CC[C@@H]1CN(C(=O)COc1cccc(N)c1)CC2.,C[NH+]1[C@H]2CC[C@@H]1CN(C(=O)COc1cccc(N)c1)CC2,amine
+130517,Please remove a amide from the molecule C=CCNC(=S)NNC(=O)c1cnc(-c2cnn(C)c2)s1.,C=CCNC(=S)NNC(=O)c1cnc(-c2cnn(C)c2)s1,amide
+152902,Modify the molecule CCC1(CC)CCN(c2cccc(F)c2C(C)=O)C1 by removing a halo.,CCC1(CC)CCN(c2cccc(F)c2C(C)=O)C1,halo
+94604,Remove a amide from the molecule Cc1c(NC(=O)/C=C/c2ccccc2Br)c(=O)n(-c2ccccc2)n1C.,Cc1c(NC(=O)/C=C/c2ccccc2Br)c(=O)n(-c2ccccc2)n1C,amide
+237759,Remove a benzene_ring from the molecule c1ccc(-n2cnnc2SCC2CCOCC2)cc1.,c1ccc(-n2cnnc2SCC2CCOCC2)cc1,benzene_ring
+82724,Please remove a amine from the molecule O=C([O-])c1cccc(-c2cc(NCc3ccccn3)nc3[nH]ccc23)c1.,O=C([O-])c1cccc(-c2cc(NCc3ccccn3)nc3[nH]ccc23)c1,amine
+12679,Please remove a benzene_ring from the molecule CCCNC(=O)CNC(=O)Nc1ccccc1SC1CCCC1.,CCCNC(=O)CNC(=O)Nc1ccccc1SC1CCCC1,benzene_ring
+50786,Modify the molecule Cc1ccc([C@](C)(O)CNC(=O)C(=O)Nc2ccc(Cl)cc2)o1 by removing a amide.,Cc1ccc([C@](C)(O)CNC(=O)C(=O)Nc2ccc(Cl)cc2)o1,amide
+215018,Please remove a hydroxyl from the molecule CCC[NH+]1CCC(NC(=O)N[C@@H](CO)c2cccc(OC)c2)CC1.,CCC[NH+]1CCC(NC(=O)N[C@@H](CO)c2cccc(OC)c2)CC1,hydroxyl
+54702,Remove a benzene_ring from the molecule COc1cccc2c1N(S(=O)(=O)c1ccc(C#N)cc1C)CCC2.,COc1cccc2c1N(S(=O)(=O)c1ccc(C#N)cc1C)CCC2,benzene_ring
+141911,Please remove a amide from the molecule COc1ccc(-c2csc(NC(=O)CSc3ccc(NC(C)=O)cc3)n2)cc1.,COc1ccc(-c2csc(NC(=O)CSc3ccc(NC(C)=O)cc3)n2)cc1,amide
+196777,Modify the molecule Cc1cnc([C@@H](C)NC(=O)N[C@@H]2C[C@H](C)N(c3ccccc3)C2=O)s1 by removing a amide.,Cc1cnc([C@@H](C)NC(=O)N[C@@H]2C[C@H](C)N(c3ccccc3)C2=O)s1,amide
+231735,Please remove a hydroxyl from the molecule O=c1c2cnc3ncnn3c2ccn1CCCO.,O=c1c2cnc3ncnn3c2ccn1CCCO,hydroxyl
+19214,Please remove a amine from the molecule Cc1cc(C)c(C(N)=O)c(N[C@H]2C=C[C@H](C(=O)[O-])C2)[nH+]1.,Cc1cc(C)c(C(N)=O)c(N[C@H]2C=C[C@H](C(=O)[O-])C2)[nH+]1,amine
+190465,Remove a benzene_ring from the molecule C[C@H](Oc1ccccc1)c1nnc(NC(=O)Nc2cccc(Cl)c2)s1.,C[C@H](Oc1ccccc1)c1nnc(NC(=O)Nc2cccc(Cl)c2)s1,benzene_ring
+201410,Remove a halo from the molecule CC(C)Oc1ccc(CNC(=O)[C@@H](C)Oc2ccccc2)cc1F.,CC(C)Oc1ccc(CNC(=O)[C@@H](C)Oc2ccccc2)cc1F,halo
+162707,Remove a halo from the molecule CN(C(=O)N[C@H](Cc1ccccc1)c1ccccc1F)C1CCS(=O)CC1.,CN(C(=O)N[C@H](Cc1ccccc1)c1ccccc1F)C1CCS(=O)CC1,halo
+159092,Remove a amine from the molecule O=C(CN1CCN(C(=O)[C@@]23CNC[C@@H]2C[NH2+]C3)CC1)N1CCCCC1.,O=C(CN1CCN(C(=O)[C@@]23CNC[C@@H]2C[NH2+]C3)CC1)N1CCCCC1,amine
+64474,Modify the molecule Cc1cccc(O[C@@H](C)C(=O)Nc2nc3ccc(S(C)(=O)=O)cc3s2)c1 by removing a amide.,Cc1cccc(O[C@@H](C)C(=O)Nc2nc3ccc(S(C)(=O)=O)cc3s2)c1,amide
+167246,Please remove a hydroxyl from the molecule Cc1ccsc1[C@H](O)[C@@H]1CCOC2(CCSCC2)C1.,Cc1ccsc1[C@H](O)[C@@H]1CCOC2(CCSCC2)C1,hydroxyl
+54313,Please remove a halo from the molecule CSC[C@H](CCO)NC(=O)Nc1cc(Br)cn(C)c1=O.,CSC[C@H](CCO)NC(=O)Nc1cc(Br)cn(C)c1=O,halo
+166187,Please remove a benzene_ring from the molecule O=C(COc1ccc(-n2cnnn2)cc1)Nc1cccc(S(=O)(=O)N2CCCC2)c1.,O=C(COc1ccc(-n2cnnn2)cc1)Nc1cccc(S(=O)(=O)N2CCCC2)c1,benzene_ring
+150511,Remove a hydroxyl from the molecule COc1ccc([C@@H](C)[C@H](C)N[C@@H](CO)c2cc(F)c(F)c(F)c2)cc1.,COc1ccc([C@@H](C)[C@H](C)N[C@@H](CO)c2cc(F)c(F)c(F)c2)cc1,hydroxyl
+40740,Remove a amide from the molecule CCn1cc(NC(=O)C[NH+]2CCC[C@H](Cc3nc4ccccc4[nH]3)C2)c(C)n1.,CCn1cc(NC(=O)C[NH+]2CCC[C@H](Cc3nc4ccccc4[nH]3)C2)c(C)n1,amide
+80571,Remove a benzene_ring from the molecule CCOC(=O)[C@H]1C(C)=CC(=O)C[C@H]1c1ccccc1.,CCOC(=O)[C@H]1C(C)=CC(=O)C[C@H]1c1ccccc1,benzene_ring
+116681,Modify the molecule CCc1nc(C[NH+]2CCC(CNC(=O)C3CC[NH+](C)CC3)CC2)cs1 by removing a amide.,CCc1nc(C[NH+]2CCC(CNC(=O)C3CC[NH+](C)CC3)CC2)cs1,amide
+175679,Remove a halo from the molecule Fc1ccc(-c2cn3c(n2)-c2ccccc2C3)cc1.,Fc1ccc(-c2cn3c(n2)-c2ccccc2C3)cc1,halo
+197062,Remove a amide from the molecule O=C(CC[NH+]1CCC(C(F)(F)F)CC1)Nc1ccc(F)cc1.,O=C(CC[NH+]1CCC(C(F)(F)F)CC1)Nc1ccc(F)cc1,amide
+178309,Remove a amide from the molecule O=C(NCc1ccc(F)cc1F)C1CCN(c2ncnc3c2oc2ccccc23)CC1.,O=C(NCc1ccc(F)cc1F)C1CCN(c2ncnc3c2oc2ccccc23)CC1,amide
+212992,Remove a amide from the molecule COc1ccc2c(c1)CCC1=C2N=N[C@@H]1C(=O)N1CC[NH+](C)CC1.,COc1ccc2c(c1)CCC1=C2N=N[C@@H]1C(=O)N1CC[NH+](C)CC1,amide
+160405,Remove a benzene_ring from the molecule O=C(NCCc1nc2ccccc2s1)c1ccc(N2CCOCC2)cc1.,O=C(NCCc1nc2ccccc2s1)c1ccc(N2CCOCC2)cc1,benzene_ring
+162186,Remove a amide from the molecule Cc1ccc(-n2nc(C(=O)N3CCCC3)c(=O)n(Cc3ccccc3)c2=O)cc1C.,Cc1ccc(-n2nc(C(=O)N3CCCC3)c(=O)n(Cc3ccccc3)c2=O)cc1C,amide
+69710,Please remove a amide from the molecule CCc1c(C)sc(NC(=O)[C@H]2CC(C)=C(C)C[C@H]2C(=O)[O-])c1C(=O)NC1CC1.,CCc1c(C)sc(NC(=O)[C@H]2CC(C)=C(C)C[C@H]2C(=O)[O-])c1C(=O)NC1CC1,amide
+177502,Modify the molecule O=C(/C=C/c1ccc(Cl)cc1Cl)Nn1cnnc1 by removing a amide.,O=C(/C=C/c1ccc(Cl)cc1Cl)Nn1cnnc1,amide
+14220,Modify the molecule O=C(NCCCCN1CCOCC1)C(=O)Nc1cccc(F)c1 by removing a benzene_ring.,O=C(NCCCCN1CCOCC1)C(=O)Nc1cccc(F)c1,benzene_ring
+204754,Remove a benzene_ring from the molecule COc1ccc2c(c1OC)C(=O)O[C@@H]2NNC(=O)c1ccccc1Br.,COc1ccc2c(c1OC)C(=O)O[C@@H]2NNC(=O)c1ccccc1Br,benzene_ring
+196044,Remove a halo from the molecule C[C@@H]1CCCC[C@@H]1NC(=O)C[NH+]1CCC[C@H](n2c(=O)oc3ccc(Cl)cc32)C1.,C[C@@H]1CCCC[C@@H]1NC(=O)C[NH+]1CCC[C@H](n2c(=O)oc3ccc(Cl)cc32)C1,halo
+8872,Remove a benzene_ring from the molecule COc1cc(C#N)cc(I)c1OCC(=O)[O-].,COc1cc(C#N)cc(I)c1OCC(=O)[O-],benzene_ring
+77677,Remove a hydroxyl from the molecule CC(C)c1nc2sc3c(NCCCO)ncnc3c2c2c1CCCC2.,CC(C)c1nc2sc3c(NCCCO)ncnc3c2c2c1CCCC2,hydroxyl
+1800,Remove a amide from the molecule Cc1nc(C)c(C(=O)OCC(=O)N[C@H]2CCCc3ccccc32)s1.,Cc1nc(C)c(C(=O)OCC(=O)N[C@H]2CCCc3ccccc32)s1,amide
+10928,Please remove a amide from the molecule COc1ccc(NC(=O)[C@@H]2CC(=O)OC2(C)C)cn1.,COc1ccc(NC(=O)[C@@H]2CC(=O)OC2(C)C)cn1,amide
+80795,Please remove a halo from the molecule N#C[C@H](NC(=O)[C@H]1CCOc2ccccc21)c1ccc(Cl)c(Cl)c1.,N#C[C@H](NC(=O)[C@H]1CCOc2ccccc21)c1ccc(Cl)c(Cl)c1,halo
+183163,Remove a amide from the molecule CCNC(=O)[C@@H]1CCCN(C(=O)N[C@@H](CCCO)c2ccccc2)C1.,CCNC(=O)[C@@H]1CCCN(C(=O)N[C@@H](CCCO)c2ccccc2)C1,amide
+145485,Remove a amine from the molecule CC(C)(C)OC(=O)[C@H](N)c1ccnc(C#N)c1.,CC(C)(C)OC(=O)[C@H](N)c1ccnc(C#N)c1,amine
+186523,Modify the molecule CCc1ccc(NS(=O)(=O)c2ccc3[nH]c(=O)c(=O)[nH]c3c2)cc1 by removing a amine.,CCc1ccc(NS(=O)(=O)c2ccc3[nH]c(=O)c(=O)[nH]c3c2)cc1,amine
+98075,Please remove a amide from the molecule CCCNC(=O)C[C@@H](C[NH3+])N1CC[NH+](C(C)(C)C)CC1.,CCCNC(=O)C[C@@H](C[NH3+])N1CC[NH+](C(C)(C)C)CC1,amide
+12410,Modify the molecule COc1cccc(NC(=O)[C@@H](NC(=O)c2ccco2)C(C)C)c1 by removing a amide.,COc1cccc(NC(=O)[C@@H](NC(=O)c2ccco2)C(C)C)c1,amide
+136377,Please remove a benzene_ring from the molecule O=C(COC(=O)c1ccccc1Br)NCC(F)(F)F.,O=C(COC(=O)c1ccccc1Br)NCC(F)(F)F,benzene_ring
+219376,Remove a benzene_ring from the molecule O=C([O-])CC1(Nc2ccc(C(F)(F)F)cc2)CCC1.,O=C([O-])CC1(Nc2ccc(C(F)(F)F)cc2)CCC1,benzene_ring
+91829,Please remove a amide from the molecule COc1ccc2c(c1)=C1CCN3C(=O)CN(Cc4ccco4)C(=O)[C@]3(C)[C@H]1[NH+]=2.,COc1ccc2c(c1)=C1CCN3C(=O)CN(Cc4ccco4)C(=O)[C@]3(C)[C@H]1[NH+]=2,amide
+247209,Please remove a hydroxyl from the molecule Cc1ccc(Oc2ccc(NC(=O)N[C@H]3[C@@H](CO)[C@H]4CC[C@@H]3C4)cc2)nn1.,Cc1ccc(Oc2ccc(NC(=O)N[C@H]3[C@@H](CO)[C@H]4CC[C@@H]3C4)cc2)nn1,hydroxyl
+74243,Please remove a benzene_ring from the molecule CCOCc1cccc(CNC(=O)c2cccc(NC(N)=O)c2)c1.,CCOCc1cccc(CNC(=O)c2cccc(NC(N)=O)c2)c1,benzene_ring
+170586,Remove a halo from the molecule CCOC(=O)[C@H](C)N(C)Cc1c[nH]nc1-c1c(F)cccc1F.,CCOC(=O)[C@H](C)N(C)Cc1c[nH]nc1-c1c(F)cccc1F,halo
+67195,Modify the molecule CNS(=O)(=O)c1cc(OC)c(Cl)cc1OC by removing a benzene_ring.,CNS(=O)(=O)c1cc(OC)c(Cl)cc1OC,benzene_ring
+5990,Please remove a amide from the molecule Cc1ccccc1C(=O)Nc1ccc(OCC(=O)[O-])c(-c2nc3ccccc3s2)c1.,Cc1ccccc1C(=O)Nc1ccc(OCC(=O)[O-])c(-c2nc3ccccc3s2)c1,amide
+200020,Remove a benzene_ring from the molecule CCc1cccc(C)c1NC(=O)N[C@@H](C)C[NH+]1CCCCC1.,CCc1cccc(C)c1NC(=O)N[C@@H](C)C[NH+]1CCCCC1,benzene_ring
+153121,Modify the molecule O=S(=O)(CC1CCC1)[N-]c1ccc(OC[C@@H]2CCCO2)cc1 by removing a benzene_ring.,O=S(=O)(CC1CCC1)[N-]c1ccc(OC[C@@H]2CCCO2)cc1,benzene_ring
+164821,Remove a halo from the molecule COc1ccc(F)cc1C(=O)N(CCc1cccc(F)c1)C1CC1.,COc1ccc(F)cc1C(=O)N(CCc1cccc(F)c1)C1CC1,halo
+221605,Modify the molecule Cc1c(Cl)c(C(=O)N2CCOC[C@@H](O)C2)nn1C by removing a amide.,Cc1c(Cl)c(C(=O)N2CCOC[C@@H](O)C2)nn1C,amide
+128109,Please remove a amine from the molecule COc1c(C)cnc(CNS(=O)(=O)N2CCCC[C@H]2C)c1C.,COc1c(C)cnc(CNS(=O)(=O)N2CCCC[C@H]2C)c1C,amine
+155047,Please remove a benzene_ring from the molecule CCOc1ccc(N2C(=O)O[C@@H](c3ccccc3)[C@]2(O)c2ccccc2)cc1.,CCOc1ccc(N2C(=O)O[C@@H](c3ccccc3)[C@]2(O)c2ccccc2)cc1,benzene_ring
+115677,Modify the molecule C[C@@H](C#N)CNC(=O)Nc1ccn(C)n1 by removing a nitrile.,C[C@@H](C#N)CNC(=O)Nc1ccn(C)n1,nitrile
+38125,Remove a amide from the molecule O=C1N[C@@H](/C=C/c2ccco2)N2CCOC[C@H]12.,O=C1N[C@@H](/C=C/c2ccco2)N2CCOC[C@H]12,amide
+136367,Remove a benzene_ring from the molecule Cc1ccccc1[C@H](CO)CCCS(C)(=O)=O.,Cc1ccccc1[C@H](CO)CCCS(C)(=O)=O,benzene_ring
+175475,Please remove a benzene_ring from the molecule COc1ccc(S(=O)(=O)N(C)C(=O)[C@@H](C)c2cccc(F)c2)cc1.,COc1ccc(S(=O)(=O)N(C)C(=O)[C@@H](C)c2cccc(F)c2)cc1,benzene_ring
+199100,Remove a benzene_ring from the molecule Cc1cccc(N2N=C(C(=O)NCc3ccccc3)CCC2=O)c1.,Cc1cccc(N2N=C(C(=O)NCc3ccccc3)CCC2=O)c1,benzene_ring
+80551,Please remove a benzene_ring from the molecule COc1cccc([C@]2(C(C)(C)C)CCC[NH2+]2)c1.,COc1cccc([C@]2(C(C)(C)C)CCC[NH2+]2)c1,benzene_ring
+1796,Please remove a benzene_ring from the molecule CC[C@H](C)NC(=O)CNC(=O)c1ccc(C)c(C)c1.,CC[C@H](C)NC(=O)CNC(=O)c1ccc(C)c(C)c1,benzene_ring
+61981,Please remove a halo from the molecule N#C/C(=C\c1cccc(OC2CCCC2)c1)c1ccc(C(F)(F)F)cn1.,N#C/C(=C\c1cccc(OC2CCCC2)c1)c1ccc(C(F)(F)F)cn1,halo
+48780,Modify the molecule C[C@H]1CN(C(=O)C[NH+](C)[C@@H](C)c2cccc(NC(=O)c3ccccc3)c2)CCO1 by removing a benzene_ring.,C[C@H]1CN(C(=O)C[NH+](C)[C@@H](C)c2cccc(NC(=O)c3ccccc3)c2)CCO1,benzene_ring
+144854,Please remove a amine from the molecule CC[C@@H]1CCCCN1c1ncccc1C(N)=S.,CC[C@@H]1CCCCN1c1ncccc1C(N)=S,amine
+19596,Remove a benzene_ring from the molecule COc1cccc(S(=O)(=O)/N=C([O-])/C(C#N)=C\c2ccco2)c1.,COc1cccc(S(=O)(=O)/N=C([O-])/C(C#N)=C\c2ccco2)c1,benzene_ring
+28562,Please remove a amide from the molecule CC1=NN(c2ccc(C(=O)N3CCN(Cc4ccsc4)CC3)cc2)CC1.,CC1=NN(c2ccc(C(=O)N3CCN(Cc4ccsc4)CC3)cc2)CC1,amide
+109320,Modify the molecule Cc1cc(C)c(C(=O)N[C@@H]2CCCc3ccccc32)c(=O)[nH]1 by removing a amide.,Cc1cc(C)c(C(=O)N[C@@H]2CCCc3ccccc32)c(=O)[nH]1,amide
+108288,Please remove a benzene_ring from the molecule CC[C@H]1C[NH+]2CCCC[C@@H]2CN1c1cccc(Cl)c1C.,CC[C@H]1C[NH+]2CCCC[C@@H]2CN1c1cccc(Cl)c1C,benzene_ring
+200821,Remove a benzene_ring from the molecule CC[C@H](NC(=O)NC[C@H](O)C1CCOCC1)c1cc(F)ccc1F.,CC[C@H](NC(=O)NC[C@H](O)C1CCOCC1)c1cc(F)ccc1F,benzene_ring
+147964,Modify the molecule CCCN[C@]1(C(=O)OC)CC[C@H](n2cc(Cl)cn2)C1 by removing a halo.,CCCN[C@]1(C(=O)OC)CC[C@H](n2cc(Cl)cn2)C1,halo
+223895,Modify the molecule COCC[C@]1(C)CC(=O)NC(=O)[C@@H]1C by removing a amide.,COCC[C@]1(C)CC(=O)NC(=O)[C@@H]1C,amide
+3843,Remove a amide from the molecule O=C(Nc1ccc(Cl)cc1)c1coc(NC(=O)c2ccco2)n1.,O=C(Nc1ccc(Cl)cc1)c1coc(NC(=O)c2ccco2)n1,amide
+123576,Remove a amide from the molecule COC(=O)CCC(=O)Nc1nc(C(C)C)cs1.,COC(=O)CCC(=O)Nc1nc(C(C)C)cs1,amide
+135005,Please remove a benzene_ring from the molecule CCCC(=O)N[C@@H]1CCCN(C(=O)[C@H]2CN(Cc3ccccc3)CCO2)C1.,CCCC(=O)N[C@@H]1CCCN(C(=O)[C@H]2CN(Cc3ccccc3)CCO2)C1,benzene_ring
+40171,Remove a amide from the molecule O=C(Nc1cccc(NC(=S)Nc2ccccc2)c1)c1ccco1.,O=C(Nc1cccc(NC(=S)Nc2ccccc2)c1)c1ccco1,amide
+77346,Please remove a amide from the molecule COCCC(=O)N1CCC[C@@H](C(=O)Nc2ccc(-c3cccc(OC)c3)cc2)C1.,COCCC(=O)N1CCC[C@@H](C(=O)Nc2ccc(-c3cccc(OC)c3)cc2)C1,amide
+111617,Please remove a benzene_ring from the molecule Cc1ccc(NC(=O)NC(=O)[C@H](C)[NH2+]CC2(N3CCOCC3)CCCCC2)c(C)c1.,Cc1ccc(NC(=O)NC(=O)[C@H](C)[NH2+]CC2(N3CCOCC3)CCCCC2)c(C)c1,benzene_ring
+60033,Remove a amide from the molecule CCCNC(=O)Cn1c(=O)oc2cc(S(=O)(=O)N3C[C@H](C)C[C@@H](C)C3)ccc21.,CCCNC(=O)Cn1c(=O)oc2cc(S(=O)(=O)N3C[C@H](C)C[C@@H](C)C3)ccc21,amide
+167157,Please remove a benzene_ring from the molecule CC[NH2+][C@H](Cc1nc(C)c(C)s1)c1cccc(OCC)c1.,CC[NH2+][C@H](Cc1nc(C)c(C)s1)c1cccc(OCC)c1,benzene_ring
+144717,Please remove a amide from the molecule COC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H]1c1cccnc1.,COC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H]1c1cccnc1,amide
+233621,Modify the molecule Cc1c[nH+]c(CNCCO)[nH]1 by removing a amine.,Cc1c[nH+]c(CNCCO)[nH]1,amine
+169526,Please remove a amide from the molecule O=C1CCCOc2ccc(C(=O)N3CCc4ccccc4C3)cc21.,O=C1CCCOc2ccc(C(=O)N3CCc4ccccc4C3)cc21,amide
+91316,Remove a nitrile from the molecule Cn1c(CN2CCNC[C@@H]2C#N)cc(=O)n(C)c1=O.,Cn1c(CN2CCNC[C@@H]2C#N)cc(=O)n(C)c1=O,nitrile
+145969,Please remove a benzene_ring from the molecule NC(=O)[C@H]1CCCN(C(=O)c2cc(F)cc(F)c2)C1.,NC(=O)[C@H]1CCCN(C(=O)c2cc(F)cc(F)c2)C1,benzene_ring
+110714,Please remove a amide from the molecule COc1cccc2ccc(C[NH+]3CCc4nnc([C@H](C)NC(=O)C5CC5)n4CC3)nc12.,COc1cccc2ccc(C[NH+]3CCc4nnc([C@H](C)NC(=O)C5CC5)n4CC3)nc12,amide
+24036,Please remove a benzene_ring from the molecule COc1ccc([C@H](CNC(=O)Nc2cc(C)ccc2C)[NH+]2CCCC2)cc1.,COc1ccc([C@H](CNC(=O)Nc2cc(C)ccc2C)[NH+]2CCCC2)cc1,benzene_ring
+86107,Modify the molecule CCCCN(C)C(=O)N[C@@H](c1ccccn1)c1ccccc1OC by removing a benzene_ring.,CCCCN(C)C(=O)N[C@@H](c1ccccn1)c1ccccc1OC,benzene_ring
+163264,Please remove a hydroxyl from the molecule COc1cc(C)c([C@@H](C)[NH2+][C@@H](CO)c2ccc(Cl)cc2)cc1OC.,COc1cc(C)c([C@@H](C)[NH2+][C@@H](CO)c2ccc(Cl)cc2)cc1OC,hydroxyl
+187087,Please remove a halo from the molecule Cc1nc(COC(=O)[C@@H](Oc2ccc(F)cc2F)C(C)C)no1.,Cc1nc(COC(=O)[C@@H](Oc2ccc(F)cc2F)C(C)C)no1,halo
+213352,Modify the molecule Cc1nc2ccccc2n1-c1ncc(Cl)cc1Cl by removing a halo.,Cc1nc2ccccc2n1-c1ncc(Cl)cc1Cl,halo
+165709,Modify the molecule COc1ccc2cc(Br)ccc2c1CC(=O)NNC(=O)c1ccc([N+](=O)[O-])cc1 by removing a benzene_ring.,COc1ccc2cc(Br)ccc2c1CC(=O)NNC(=O)c1ccc([N+](=O)[O-])cc1,benzene_ring
+127976,Modify the molecule [NH3+]CCOc1ccc(NC(=O)c2ccccn2)cc1 by removing a amide.,[NH3+]CCOc1ccc(NC(=O)c2ccccn2)cc1,amide
+151869,Modify the molecule COc1ccc([C@H](C)N[C@@H](C)C(=O)Nc2ccccc2)c(F)c1 by removing a amine.,COc1ccc([C@H](C)N[C@@H](C)C(=O)Nc2ccccc2)c(F)c1,amine
+184041,Please remove a halo from the molecule CC[NH+]1CCN(c2ncnc(Nc3cc(Cl)ccc3Cl)c2[N+](=O)[O-])CC1.,CC[NH+]1CCN(c2ncnc(Nc3cc(Cl)ccc3Cl)c2[N+](=O)[O-])CC1,halo
+11269,Modify the molecule COc1ccccc1C[NH2+]CC1(N(C)C)CCOCC1 by removing a benzene_ring.,COc1ccccc1C[NH2+]CC1(N(C)C)CCOCC1,benzene_ring
+164891,Please remove a benzene_ring from the molecule C[C@H]([NH2+]Cc1ccc(OC(F)(F)F)cc1)c1ccc(-n2cncn2)cc1.,C[C@H]([NH2+]Cc1ccc(OC(F)(F)F)cc1)c1ccc(-n2cncn2)cc1,benzene_ring
+44507,Remove a benzene_ring from the molecule CC1(C)CCN(C(=O)[C@H](c2ccccc2)N2CCSCC2)C1.,CC1(C)CCN(C(=O)[C@H](c2ccccc2)N2CCSCC2)C1,benzene_ring
+159151,Please remove a amide from the molecule Cc1cccc2sc(NC(=O)[C@@H]3C[C@@H]3C)nc12.,Cc1cccc2sc(NC(=O)[C@@H]3C[C@@H]3C)nc12,amide
+91444,Remove a amide from the molecule C[C@@H](C(=O)OCC(=O)N1CCCCC1)N1C(=O)c2ccccc2C1=O.,C[C@@H](C(=O)OCC(=O)N1CCCCC1)N1C(=O)c2ccccc2C1=O,amide
+211205,Remove a hydroxyl from the molecule CSc1ccc(C(=O)[C@@H]2CCC[NH+](Cc3ccc(C#CC(C)(C)O)s3)C2)cc1.,CSc1ccc(C(=O)[C@@H]2CCC[NH+](Cc3ccc(C#CC(C)(C)O)s3)C2)cc1,hydroxyl
+42213,Please remove a benzene_ring from the molecule O=C(Nc1ccccc1C(=O)N1CCCCC1)c1cccs1.,O=C(Nc1ccccc1C(=O)N1CCCCC1)c1cccs1,benzene_ring
+164760,Please remove a halo from the molecule COc1cc([C@H](O)c2cc(F)c(F)c(F)c2)ccc1Cl.,COc1cc([C@H](O)c2cc(F)c(F)c(F)c2)ccc1Cl,halo
+98529,Please remove a benzene_ring from the molecule CC[C@H](CSC)N(C)C(=O)NCc1ccc(OC)c(Cl)c1.,CC[C@H](CSC)N(C)C(=O)NCc1ccc(OC)c(Cl)c1,benzene_ring
+201989,Remove a amide from the molecule CCn1cc(C(=O)C(=O)NC2CC(C)(C)[NH2+]C(C)(C)C2)cn1.,CCn1cc(C(=O)C(=O)NC2CC(C)(C)[NH2+]C(C)(C)C2)cn1,amide
+8226,Modify the molecule O=C1C[C@H](C(=O)NCCC2=CCCCC2)Cc2nc(NC(=O)c3c(F)cccc3Cl)sc21 by removing a benzene_ring.,O=C1C[C@H](C(=O)NCCC2=CCCCC2)Cc2nc(NC(=O)c3c(F)cccc3Cl)sc21,benzene_ring
+192529,Remove a amide from the molecule CCc1cc(N2CCC(NC(=O)C3C[C@@H](C)O[C@H](C)C3)CC2)ncn1.,CCc1cc(N2CCC(NC(=O)C3C[C@@H](C)O[C@H](C)C3)CC2)ncn1,amide
+227697,Remove a benzene_ring from the molecule NC(=O)C[C@H](C(=O)[O-])N1C(=O)/C(=C/c2ccccc2)SC1=S.,NC(=O)C[C@H](C(=O)[O-])N1C(=O)/C(=C/c2ccccc2)SC1=S,benzene_ring
+179613,Remove a amide from the molecule Cc1cccnc1C[NH+]1CCC[C@H](C(=O)N(C)C)C1.,Cc1cccnc1C[NH+]1CCC[C@H](C(=O)N(C)C)C1,amide
+150430,Modify the molecule CC[NH2+][C@H]1CC[C@@H](SC[C@@H](C)CO)C1 by removing a hydroxyl.,CC[NH2+][C@H]1CC[C@@H](SC[C@@H](C)CO)C1,hydroxyl
+158,Modify the molecule COc1ccc([C@@H]([NH2+]Cc2ccc(Cl)nc2)c2ccc(F)cc2)cc1 by removing a halo.,COc1ccc([C@@H]([NH2+]Cc2ccc(Cl)nc2)c2ccc(F)cc2)cc1,halo
+134912,Remove a amide from the molecule C[C@H]1C[C@H]1C(=O)N1CCN(Cc2csc(CC(=O)N(C)C)n2)CC1.,C[C@H]1C[C@H]1C(=O)N1CCN(Cc2csc(CC(=O)N(C)C)n2)CC1,amide
+163661,Please remove a amide from the molecule Cc1ccc([C@H](C)NC(=O)CC2(C(=O)[O-])CCCC2)o1.,Cc1ccc([C@H](C)NC(=O)CC2(C(=O)[O-])CCCC2)o1,amide
+175871,Modify the molecule Cc1ccc(NC(=O)C2CCC(N3C(=O)[C@H]4[C@H]5CC[C@H](C5)[C@H]4C3=O)CC2)cc1 by removing a amide.,Cc1ccc(NC(=O)C2CCC(N3C(=O)[C@H]4[C@H]5CC[C@H](C5)[C@H]4C3=O)CC2)cc1,amide
+31076,Remove a benzene_ring from the molecule CCOCc1ccccc1NC(=O)c1ccc(-c2cscn2)cc1.,CCOCc1ccccc1NC(=O)c1ccc(-c2cscn2)cc1,benzene_ring
+140319,Modify the molecule C[C@@H](CCc1ccco1)[NH2+]C[C@](C)(O)c1ccc(F)cc1F by removing a halo.,C[C@@H](CCc1ccco1)[NH2+]C[C@](C)(O)c1ccc(F)cc1F,halo
+81274,Modify the molecule N#Cc1ccc(Cc2cnc(N)s2)cc1 by removing a amine.,N#Cc1ccc(Cc2cnc(N)s2)cc1,amine
+36847,Please remove a amine from the molecule O=[N+]([O-])c1ccc(F)c2c1[C@H]1C=CC[C@H]1[C@H](c1cccnc1)N2.,O=[N+]([O-])c1ccc(F)c2c1[C@H]1C=CC[C@H]1[C@H](c1cccnc1)N2,amine
+223814,Remove a amide from the molecule CCN(C(=O)[C@@H]1CC(=O)N(c2ccccc2Cl)C1)[C@H](C)c1cccc(OC)c1.,CCN(C(=O)[C@@H]1CC(=O)N(c2ccccc2Cl)C1)[C@H](C)c1cccc(OC)c1,amide
+191188,Please remove a benzene_ring from the molecule C[C@H](NC(=O)[C@@H]1CCC[NH+](C)C1)c1ccc(NC(=O)NC2CC2)cc1.,C[C@H](NC(=O)[C@@H]1CCC[NH+](C)C1)c1ccc(NC(=O)NC2CC2)cc1,benzene_ring
+1487,Remove a halo from the molecule CSc1ccc2c(C)cc(N3CCO[C@@H](C(F)(F)F)C3)nc2c1.,CSc1ccc2c(C)cc(N3CCO[C@@H](C(F)(F)F)C3)nc2c1,halo
+101368,Please remove a amide from the molecule CO[C@@H](CNC(=O)Nc1ccc(N(C)C(C)=O)cc1)c1ccc(F)cc1.,CO[C@@H](CNC(=O)Nc1ccc(N(C)C(C)=O)cc1)c1ccc(F)cc1,amide
+24927,Please remove a amide from the molecule C[C@H](CNC(=O)c1ccn(-c2ccccc2F)n1)c1ccsc1.,C[C@H](CNC(=O)c1ccn(-c2ccccc2F)n1)c1ccsc1,amide
+185091,Modify the molecule CN(C)S(=O)(=O)c1ccc(NC(=O)CSc2nnc(-c3ccc(F)cc3)o2)cc1 by removing a benzene_ring.,CN(C)S(=O)(=O)c1ccc(NC(=O)CSc2nnc(-c3ccc(F)cc3)o2)cc1,benzene_ring
+232673,Please remove a amine from the molecule CN(C(=O)[O-])c1ccc2c(c1)CCN2.,CN(C(=O)[O-])c1ccc2c(c1)CCN2,amine
+134392,Remove a amide from the molecule C[C@@H]1CC([NH+]2CCN(CC(=O)N3CCCCC3)CC2)C[C@@H](C)C1.,C[C@@H]1CC([NH+]2CCN(CC(=O)N3CCCCC3)CC2)C[C@@H](C)C1,amide
+53275,Remove a amide from the molecule CN(C)C(=O)CN(C)C(=O)c1cc2ccccc2[nH]1.,CN(C)C(=O)CN(C)C(=O)c1cc2ccccc2[nH]1,amide
+39033,Remove a nitrile from the molecule CC(=O)[C@@H]1[C@@H](c2ccc(F)cc2F)C(C#N)(C#N)[C@H]2c3ccccc3C=CN12.,CC(=O)[C@@H]1[C@@H](c2ccc(F)cc2F)C(C#N)(C#N)[C@H]2c3ccccc3C=CN12,nitrile
+90225,Remove a benzene_ring from the molecule C[C@@H]1CCN(C(=O)N[C@@H](CS(C)(=O)=O)c2ccccc2)C[C@H](C)C1.,C[C@@H]1CCN(C(=O)N[C@@H](CS(C)(=O)=O)c2ccccc2)C[C@H](C)C1,benzene_ring
+112651,Remove a amide from the molecule CCc1nn(C)c(OC)c1CNC(=O)CCN1c2ccccc2CC[C@@H]1C.,CCc1nn(C)c(OC)c1CNC(=O)CCN1c2ccccc2CC[C@@H]1C,amide
+138912,Please remove a amine from the molecule CC(C)Nc1cc2ccccc2cc1C(=O)[O-].,CC(C)Nc1cc2ccccc2cc1C(=O)[O-],amine
+88403,Please remove a halo from the molecule CC(C)(C)OC(=O)N1CCC[C@@H](CCOCc2ccc(Cl)nn2)C1.,CC(C)(C)OC(=O)N1CCC[C@@H](CCOCc2ccc(Cl)nn2)C1,halo
+246686,Remove a amine from the molecule C[C@@]12CCCC[C@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)/C(=N/N)CC[C@H]12.,C[C@@]12CCCC[C@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)/C(=N/N)CC[C@H]12,amine
+94134,Modify the molecule Cc1csc(C[S@@](=O)c2ccccc2F)n1 by removing a benzene_ring.,Cc1csc(C[S@@](=O)c2ccccc2F)n1,benzene_ring
+38010,Remove a halo from the molecule O=C([O-])c1nn(-c2ccc(Br)cc2)c(=O)c2ccccc12.,O=C([O-])c1nn(-c2ccc(Br)cc2)c(=O)c2ccccc12,halo
+227342,Remove a benzene_ring from the molecule CCCOc1ccccc1NC(=O)C(=O)NC[C@@H]1CCC[C@@H]1O.,CCCOc1ccccc1NC(=O)C(=O)NC[C@@H]1CCC[C@@H]1O,benzene_ring
+201716,Please remove a amide from the molecule CCCc1[nH]nc(C(=O)Nc2cnc(-c3ccccc3)s2)c1[N+](=O)[O-].,CCCc1[nH]nc(C(=O)Nc2cnc(-c3ccccc3)s2)c1[N+](=O)[O-],amide
+178188,Remove a amide from the molecule O=C1C[C@H](N2CCN(c3ccc(O)cc3)CC2)C(=O)N1c1cccc(Cl)c1.,O=C1C[C@H](N2CCN(c3ccc(O)cc3)CC2)C(=O)N1c1cccc(Cl)c1,amide
+96056,Modify the molecule CC(C)CNC(=O)c1c(N)n(/N=C/c2ccc(F)cc2)c2nc3ccccc3nc12 by removing a halo.,CC(C)CNC(=O)c1c(N)n(/N=C/c2ccc(F)cc2)c2nc3ccccc3nc12,halo
+217036,Please remove a benzene_ring from the molecule NC(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)CCN1S(=O)(=O)c1ccccc1.,NC(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)CCN1S(=O)(=O)c1ccccc1,benzene_ring
+96293,Modify the molecule CCc1nc2ncc3c(n2n1)C[C@@H](c1ccccc1C)CC3=O by removing a benzene_ring.,CCc1nc2ncc3c(n2n1)C[C@@H](c1ccccc1C)CC3=O,benzene_ring
+240132,Please remove a benzene_ring from the molecule CCc1ccc(C(=O)Cc2ccc([N+](=O)[O-])cc2)o1.,CCc1ccc(C(=O)Cc2ccc([N+](=O)[O-])cc2)o1,benzene_ring
+145284,Please remove a amide from the molecule COc1cccc([C@@H]2CCC[NH+]2CCCN2C(=O)NC(C)(C)C2=O)c1.,COc1cccc([C@@H]2CCC[NH+]2CCCN2C(=O)NC(C)(C)C2=O)c1,amide
+63031,Modify the molecule CC(C)(CNC(=O)CCC(F)(F)F)c1ccccc1F by removing a halo.,CC(C)(CNC(=O)CCC(F)(F)F)c1ccccc1F,halo
+75232,Remove a amide from the molecule CSc1cccc2sc(N3CCN(C(=O)C(C)C)CC3)nc12.,CSc1cccc2sc(N3CCN(C(=O)C(C)C)CC3)nc12,amide
+94343,Remove a hydroxyl from the molecule C[C@H](O)[C@@H](C)N1CC[NH2+]CC1(C)C.,C[C@H](O)[C@@H](C)N1CC[NH2+]CC1(C)C,hydroxyl
+117110,Remove a halo from the molecule C=C(Cl)CN(C(=O)Cc1c(C)noc1C)[C@H]1CCc2ccccc21.,C=C(Cl)CN(C(=O)Cc1c(C)noc1C)[C@H]1CCc2ccccc21,halo
+180180,Please remove a benzene_ring from the molecule CC(=O)c1ccc(S(=O)(=O)N(C)CC(=O)N[C@H]2C[C@@H]2C)cc1.,CC(=O)c1ccc(S(=O)(=O)N(C)CC(=O)N[C@H]2C[C@@H]2C)cc1,benzene_ring
+111311,Remove a benzene_ring from the molecule COc1ccc(Nc2nnc(SCC(=O)c3ccc[nH]3)s2)cc1.,COc1ccc(Nc2nnc(SCC(=O)c3ccc[nH]3)s2)cc1,benzene_ring
+232608,Remove a benzene_ring from the molecule CCC(=O)N1CCC[C@H]1c1nc2ccccc2n1CCOc1ccc(Cl)c(C)c1.,CCC(=O)N1CCC[C@H]1c1nc2ccccc2n1CCOc1ccc(Cl)c(C)c1,benzene_ring
+115125,Modify the molecule CCN(Cc1ccccc1)C(=O)c1ccccc1NC(=O)c1ccccc1 by removing a benzene_ring.,CCN(Cc1ccccc1)C(=O)c1ccccc1NC(=O)c1ccccc1,benzene_ring
+116916,Remove a halo from the molecule C[C@H](CNCc1cccc(F)c1)c1ccsc1.,C[C@H](CNCc1cccc(F)c1)c1ccsc1,halo
+82301,Modify the molecule CCOC(=O)c1c(NC(=O)c2ccc(C)cc2)sc2c1CC[NH+](C(C)C)C2 by removing a benzene_ring.,CCOC(=O)c1c(NC(=O)c2ccc(C)cc2)sc2c1CC[NH+](C(C)C)C2,benzene_ring
+12666,Please remove a amide from the molecule Cc1ccc2ncc(C(=O)Nc3nnc(CC(C)C)s3)n2c1.,Cc1ccc2ncc(C(=O)Nc3nnc(CC(C)C)s3)n2c1,amide
+140222,Modify the molecule Cc1noc(C)c1[C@H](C)NC(=O)[C@@H](C)C[NH3+] by removing a amide.,Cc1noc(C)c1[C@H](C)NC(=O)[C@@H](C)C[NH3+],amide
+203995,Modify the molecule COc1ccc(NC(=O)C2=Cc3ccccc3OC2)cc1 by removing a benzene_ring.,COc1ccc(NC(=O)C2=Cc3ccccc3OC2)cc1,benzene_ring
+157830,Remove a amide from the molecule COC[C@@H]1CN(CCC(=O)N2CCC[C@H]2C)CCO1.,COC[C@@H]1CN(CCC(=O)N2CCC[C@H]2C)CCO1,amide
+82382,Remove a amine from the molecule CCS(=O)(=O)NCCc1cc2c(C)ccc(C)c2[nH]c1=O.,CCS(=O)(=O)NCCc1cc2c(C)ccc(C)c2[nH]c1=O,amine
+93578,Modify the molecule Cc1cc(N2CCC[C@H](C(=O)c3ccc(F)cc3)C2)ncc1[N+](=O)[O-] by removing a benzene_ring.,Cc1cc(N2CCC[C@H](C(=O)c3ccc(F)cc3)C2)ncc1[N+](=O)[O-],benzene_ring
+10060,Modify the molecule Cc1nn(-c2ccccc2F)c2ncc3c(c12)C(=O)N(c1ccc(C(C)C)cc1)C3=O by removing a halo.,Cc1nn(-c2ccccc2F)c2ncc3c(c12)C(=O)N(c1ccc(C(C)C)cc1)C3=O,halo
+221599,Please remove a benzene_ring from the molecule CC(=O)N1CC[C@@H](c2c(C(=O)Nc3cccc(OC(C)C)c3)sc3ccccc23)C1.,CC(=O)N1CC[C@@H](c2c(C(=O)Nc3cccc(OC(C)C)c3)sc3ccccc23)C1,benzene_ring
+44621,Please remove a benzene_ring from the molecule CCOc1cc(C)ccc1NC(=O)c1cccc(NC(=O)c2cccs2)c1.,CCOc1cc(C)ccc1NC(=O)c1cccc(NC(=O)c2cccs2)c1,benzene_ring
+47584,Please remove a amine from the molecule CCOc1ccc(S(=O)(=O)NC[C@H](C)C#N)cc1.,CCOc1ccc(S(=O)(=O)NC[C@H](C)C#N)cc1,amine
+14007,Remove a benzene_ring from the molecule C[C@H](CC(=O)N[C@H](C)c1nc2ccccc2[nH]1)Cc1cccc(F)c1.,C[C@H](CC(=O)N[C@H](C)c1nc2ccccc2[nH]1)Cc1cccc(F)c1,benzene_ring
+178339,Modify the molecule CCc1nc(-c2cc(C)[nH+]c3ccccc23)nc([O-])c1Br by removing a halo.,CCc1nc(-c2cc(C)[nH+]c3ccccc23)nc([O-])c1Br,halo
+232970,Remove a halo from the molecule CN(Cc1ccccc1)S(=O)(=O)c1cc(C(=O)Nc2ccc(Br)cc2)ccc1F.,CN(Cc1ccccc1)S(=O)(=O)c1cc(C(=O)Nc2ccc(Br)cc2)ccc1F,halo
+220560,Modify the molecule CC[C@@H](C)[C@@]1(O)CSCC(C)(C)C1 by removing a hydroxyl.,CC[C@@H](C)[C@@]1(O)CSCC(C)(C)C1,hydroxyl
+51392,Remove a benzene_ring from the molecule CCN(c1ccccc1)c1[nH+]cnc(Nc2nc3ccccc3s2)c1N.,CCN(c1ccccc1)c1[nH+]cnc(Nc2nc3ccccc3s2)c1N,benzene_ring
+154647,Modify the molecule CC(C)Oc1ccccc1NC(=O)Cc1csc(-c2ccoc2)n1 by removing a benzene_ring.,CC(C)Oc1ccccc1NC(=O)Cc1csc(-c2ccoc2)n1,benzene_ring
+97482,Modify the molecule C[NH+](Cc1ccccc1NC(=O)NC[C@H](O)c1ccco1)C1CCCCC1 by removing a benzene_ring.,C[NH+](Cc1ccccc1NC(=O)NC[C@H](O)c1ccco1)C1CCCCC1,benzene_ring
+190597,Please remove a benzene_ring from the molecule COC(=O)[C@@H](c1cccc(Br)c1)N(C)CC1=CCCOC1.,COC(=O)[C@@H](c1cccc(Br)c1)N(C)CC1=CCCOC1,benzene_ring
+171299,Modify the molecule C[C@@H](CSC(C)(C)C)[NH2+]C[C@]1(O)CCc2ccccc21 by removing a hydroxyl.,C[C@@H](CSC(C)(C)C)[NH2+]C[C@]1(O)CCc2ccccc21,hydroxyl
+201753,Please remove a amide from the molecule O=C(Cn1c(=O)cnc2ccccc21)N[C@H]1C[C@@H]2CCCc3cccc1c32.,O=C(Cn1c(=O)cnc2ccccc21)N[C@H]1C[C@@H]2CCCc3cccc1c32,amide
+245517,Please remove a benzene_ring from the molecule CCS(=O)(=O)[N-]c1ccc(C(=O)/C=C/c2ccc(C)c(F)c2)cc1.,CCS(=O)(=O)[N-]c1ccc(C(=O)/C=C/c2ccc(C)c(F)c2)cc1,benzene_ring
+89835,Please remove a amide from the molecule Cc1ccc(OC(=O)N2CCN3C(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]3C2)cc1.,Cc1ccc(OC(=O)N2CCN3C(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]3C2)cc1,amide
+171158,Modify the molecule CCOc1ccc(C(=O)CC(F)(F)F)c(Br)c1 by removing a halo.,CCOc1ccc(C(=O)CC(F)(F)F)c(Br)c1,halo
+224402,Please remove a amine from the molecule COC(=O)c1cc(N)ccc1N1CCCCC1.,COC(=O)c1cc(N)ccc1N1CCCCC1,amine
+233105,Modify the molecule COc1cccc(N2CC[NH+]([C@H](C)c3nc(C(C)(C)C)no3)CC2)c1 by removing a benzene_ring.,COc1cccc(N2CC[NH+]([C@H](C)c3nc(C(C)(C)C)no3)CC2)c1,benzene_ring
+211193,Remove a amide from the molecule CCCC(=O)Nc1cccc(C(=O)Nc2ccccn2)c1.,CCCC(=O)Nc1cccc(C(=O)Nc2ccccn2)c1,amide
+211399,Modify the molecule C[C@H](NC(=O)C(=O)Nc1cc(F)cc(F)c1)C(=O)NCc1ccco1 by removing a halo.,C[C@H](NC(=O)C(=O)Nc1cc(F)cc(F)c1)C(=O)NCc1ccco1,halo
+139627,Please remove a benzene_ring from the molecule Cc1nc(C(C)(C)c2ccccc2)sc1C(=O)NCc1ncoc1C.,Cc1nc(C(C)(C)c2ccccc2)sc1C(=O)NCc1ncoc1C,benzene_ring
+150825,Please remove a amide from the molecule Cc1ccc(S(=O)(=O)c2ncsc2SCC(=O)NCc2ccc(C)o2)cc1.,Cc1ccc(S(=O)(=O)c2ncsc2SCC(=O)NCc2ccc(C)o2)cc1,amide
+53880,Please remove a amide from the molecule Cc1nc(C[NH+]2CCC[C@H](CNC(=O)c3ccccc3)C2)sc1C.,Cc1nc(C[NH+]2CCC[C@H](CNC(=O)c3ccccc3)C2)sc1C,amide
+20057,Remove a benzene_ring from the molecule CCn1cnnc1[C@@H]1CCCN(C(=O)Nc2ccc(OC)cc2)C1.,CCn1cnnc1[C@@H]1CCCN(C(=O)Nc2ccc(OC)cc2)C1,benzene_ring
+232684,Modify the molecule CS(=O)(=O)c1ccc(C(=O)N2C[C@@H](C(=O)[O-])[C@H](c3ccncc3)C2)cc1 by removing a amide.,CS(=O)(=O)c1ccc(C(=O)N2C[C@@H](C(=O)[O-])[C@H](c3ccncc3)C2)cc1,amide
+68106,Modify the molecule CN[C@@](C)(c1ccoc1)C(F)(F)F by removing a halo.,CN[C@@](C)(c1ccoc1)C(F)(F)F,halo
+99379,Modify the molecule O=C1NC(=S)NC(=O)C1=CNCCc1ccc(F)cc1 by removing a benzene_ring.,O=C1NC(=S)NC(=O)C1=CNCCc1ccc(F)cc1,benzene_ring
+20520,Modify the molecule Cc1nc(NC(=O)CCn2c([S-])nnc2-c2cccs2)sc1C by removing a amide.,Cc1nc(NC(=O)CCn2c([S-])nnc2-c2cccs2)sc1C,amide
+221860,Remove a benzene_ring from the molecule O=C(/C=C1/Sc2ccccc2N(Cc2ccccc2F)C1=O)NCc1ccc2c(c1)OCO2.,O=C(/C=C1/Sc2ccccc2N(Cc2ccccc2F)C1=O)NCc1ccc2c(c1)OCO2,benzene_ring
+153806,Please remove a halo from the molecule COc1ccccc1OCCCOc1ccc(F)cc1.,COc1ccccc1OCCCOc1ccc(F)cc1,halo
+224265,Modify the molecule O=C(Nc1ccc(NC(=O)[C@@H]2CCCO2)cc1)c1cccnc1 by removing a benzene_ring.,O=C(Nc1ccc(NC(=O)[C@@H]2CCCO2)cc1)c1cccnc1,benzene_ring
+99991,Please remove a amide from the molecule C[C@H]1C[C@H](Nc2ccc(NC(=O)C[NH+](C)C)cc2)C(=O)O1.,C[C@H]1C[C@H](Nc2ccc(NC(=O)C[NH+](C)C)cc2)C(=O)O1,amide
+230837,Remove a amine from the molecule Cc1ccc(S(=O)(=O)Nc2ccc(Oc3ncnc4sccc34)cc2)cc1.,Cc1ccc(S(=O)(=O)Nc2ccc(Oc3ncnc4sccc34)cc2)cc1,amine
+34415,Remove a amide from the molecule O=C(NCc1csc(=O)[nH]1)c1coc(-c2ccccc2)n1.,O=C(NCc1csc(=O)[nH]1)c1coc(-c2ccccc2)n1,amide
+123592,Remove a benzene_ring from the molecule Cc1ccc(C(=O)N[C@@H]2C[C@H]3CC[C@]2(C)C3(C)C)cc1.,Cc1ccc(C(=O)N[C@@H]2C[C@H]3CC[C@]2(C)C3(C)C)cc1,benzene_ring
+243030,Remove a amine from the molecule CC(N[C@H]1CCCC[C@@H]1C)=C1C(=O)NC(=S)NC1=O.,CC(N[C@H]1CCCC[C@@H]1C)=C1C(=O)NC(=S)NC1=O,amine
+79276,Remove a benzene_ring from the molecule CC(C)c1ccc([C@@H](C)[NH2+]Cc2cnn(C)c2)cc1.,CC(C)c1ccc([C@@H](C)[NH2+]Cc2cnn(C)c2)cc1,benzene_ring
+21905,Modify the molecule COc1ccc(C(=O)NCc2ccc(-c3nn4cnnc4s3)cc2)cc1OC by removing a amide.,COc1ccc(C(=O)NCc2ccc(-c3nn4cnnc4s3)cc2)cc1OC,amide
+71916,Remove a halo from the molecule O=C(Nc1ccc2c(c1)OCCO2)N1CCN(c2ccc(Cl)c(Cl)c2)CC1.,O=C(Nc1ccc2c(c1)OCCO2)N1CCN(c2ccc(Cl)c(Cl)c2)CC1,halo
+152848,Remove a benzene_ring from the molecule O=C(NOCc1ccccc1)N1CCC(c2nc3ccccc3s2)CC1.,O=C(NOCc1ccccc1)N1CCC(c2nc3ccccc3s2)CC1,benzene_ring
+29264,Please remove a benzene_ring from the molecule Cc1ccc(C(CO)(CO)CCSc2ccccc2)cc1.,Cc1ccc(C(CO)(CO)CCSc2ccccc2)cc1,benzene_ring
+183946,Remove a amide from the molecule Cc1ccc([N+](=O)[O-])cc1NC(=O)c1cccc(OCCC(C)C)c1.,Cc1ccc([N+](=O)[O-])cc1NC(=O)c1cccc(OCCC(C)C)c1,amide
+244301,Remove a amide from the molecule CC(C)[C@H](C(=O)Nc1ccc(C(=O)N(C)C)cc1)c1ccc(Cl)cc1.,CC(C)[C@H](C(=O)Nc1ccc(C(=O)N(C)C)cc1)c1ccc(Cl)cc1,amide
+54689,Remove a amide from the molecule CC(C)[C@H](C)CC(=O)N1CCc2cc([N+](=O)[O-])ccc21.,CC(C)[C@H](C)CC(=O)N1CCc2cc([N+](=O)[O-])ccc21,amide
+29878,Modify the molecule CN(C[C@@H]1CCOC1)C(=O)Nc1ccc(Cl)c(CS(C)(=O)=O)c1 by removing a halo.,CN(C[C@@H]1CCOC1)C(=O)Nc1ccc(Cl)c(CS(C)(=O)=O)c1,halo
+158767,Modify the molecule CCn1c(CCNC(=O)C2(c3ccc(C(C)C)cc3)CCCC2)n[nH]c1=S by removing a benzene_ring.,CCn1c(CCNC(=O)C2(c3ccc(C(C)C)cc3)CCCC2)n[nH]c1=S,benzene_ring
+96802,Please remove a amine from the molecule C[C@H](Oc1ccc(Cl)cc1Cl)C(=O)NC(=S)Nc1ccccc1F.,C[C@H](Oc1ccc(Cl)cc1Cl)C(=O)NC(=S)Nc1ccccc1F,amine
+31213,Remove a amide from the molecule C[C@@H](SCC1=NC(=O)C2=C3CCCC[C@@H]3SC2=N1)C(=O)NC1CC1.,C[C@@H](SCC1=NC(=O)C2=C3CCCC[C@@H]3SC2=N1)C(=O)NC1CC1,amide
+84509,Modify the molecule C=CCOc1ccccc1CN1CCNC(=O)[C@@H]1c1ccccc1 by removing a amide.,C=CCOc1ccccc1CN1CCNC(=O)[C@@H]1c1ccccc1,amide
+48716,Modify the molecule O=C([O-])C[C@H]1C(=O)NCCN1C(=O)CC1CCCC1 by removing a amide.,O=C([O-])C[C@H]1C(=O)NCCN1C(=O)CC1CCCC1,amide
+222258,Remove a amide from the molecule CCc1cc(C(F)(F)F)c2c(C3CCN(C(=O)c4cn(C)nc4C)CC3)noc2n1.,CCc1cc(C(F)(F)F)c2c(C3CCN(C(=O)c4cn(C)nc4C)CC3)noc2n1,amide
+134818,Remove a halo from the molecule Nc1cnc(N(Cc2cccs2)C2CC2)c(Br)c1.,Nc1cnc(N(Cc2cccs2)C2CC2)c(Br)c1,halo
+92415,Remove a benzene_ring from the molecule COc1cccc(/N=C(\O)[C@H](C)Sc2nncn2-c2ccccc2)c1.,COc1cccc(/N=C(\O)[C@H](C)Sc2nncn2-c2ccccc2)c1,benzene_ring
+215341,Modify the molecule CC1(C)CC(NCCC(N)=O)CC(C)(C)[NH2+]1 by removing a amide.,CC1(C)CC(NCCC(N)=O)CC(C)(C)[NH2+]1,amide
+137966,Remove a halo from the molecule C[C@H]1CCCN(C(=O)Nc2ccc(CCC(F)(F)F)cc2)[C@H]1CO.,C[C@H]1CCCN(C(=O)Nc2ccc(CCC(F)(F)F)cc2)[C@H]1CO,halo
+215190,Remove a halo from the molecule COc1cccc2sc(N(C[C@H]3CCCO3)C(=O)c3ccc(Cl)cc3)nc12.,COc1cccc2sc(N(C[C@H]3CCCO3)C(=O)c3ccc(Cl)cc3)nc12,halo
+190880,Please remove a amide from the molecule CCN(Cc1ccc(OC)c(OC)c1)C(=O)CN1C[C@@H](C)O[C@H](C)C1.,CCN(Cc1ccc(OC)c(OC)c1)C(=O)CN1C[C@@H](C)O[C@H](C)C1,amide
+9486,Remove a amide from the molecule Cc1cc(NC(=O)C2CCN(C(=O)N3CCCC3)CC2)no1.,Cc1cc(NC(=O)C2CCN(C(=O)N3CCCC3)CC2)no1,amide
+41012,Please remove a amide from the molecule Cc1ccccc1NS(=O)(=O)c1ccc2[nH]cc(C(=O)N[C@@H]3CCCC[C@@H]3C)c(=O)c2c1.,Cc1ccccc1NS(=O)(=O)c1ccc2[nH]cc(C(=O)N[C@@H]3CCCC[C@@H]3C)c(=O)c2c1,amide
+43394,Please remove a benzene_ring from the molecule Cc1cc(/C=C2/C(=O)NC(=S)N=C2[O-])c(C)n1-c1cccc(C(=O)[O-])c1.,Cc1cc(/C=C2/C(=O)NC(=S)N=C2[O-])c(C)n1-c1cccc(C(=O)[O-])c1,benzene_ring
+138550,Please remove a benzene_ring from the molecule O=C(CCc1ccccc1)[C@@H]1CCCN(C(=O)CN2CCCCCC2=O)C1.,O=C(CCc1ccccc1)[C@@H]1CCCN(C(=O)CN2CCCCCC2=O)C1,benzene_ring
+67985,Modify the molecule C=CCSCC(=O)N[C@@H](C)C(=O)OC by removing a amide.,C=CCSCC(=O)N[C@@H](C)C(=O)OC,amide
+27276,Modify the molecule OC1CCC([NH2+][C@H]2CCCc3ccc(Br)cc32)CC1 by removing a hydroxyl.,OC1CCC([NH2+][C@H]2CCCc3ccc(Br)cc32)CC1,hydroxyl
+89483,Remove a halo from the molecule C[C@]1([C@H]([NH3+])c2ccc(Cl)cc2Cl)CCCO1.,C[C@]1([C@H]([NH3+])c2ccc(Cl)cc2Cl)CCCO1,halo
+227843,Remove a benzene_ring from the molecule Cc1ccc(C)c(CSc2ncc(CO)n2Cc2ccccc2)c1.,Cc1ccc(C)c(CSc2ncc(CO)n2Cc2ccccc2)c1,benzene_ring
+162863,Modify the molecule NC(=O)c1cccc(CNC(=O)NCC2CCN(c3cc[nH+]cc3)CC2)c1 by removing a amide.,NC(=O)c1cccc(CNC(=O)NCC2CCN(c3cc[nH+]cc3)CC2)c1,amide
+240712,Please remove a halo from the molecule CC1(C)C(C[NH2+]Cc2ccc(Br)cn2)C1(C)C.,CC1(C)C(C[NH2+]Cc2ccc(Br)cn2)C1(C)C,halo
+96447,Remove a benzene_ring from the molecule Cn1c([O-])c(Sc2ccc([N+](=O)[O-])cc2)c(=O)c2ccccc21.,Cn1c([O-])c(Sc2ccc([N+](=O)[O-])cc2)c(=O)c2ccccc21,benzene_ring
+220810,Please remove a benzene_ring from the molecule Cc1ccccc1[C@@H](C)NC(=O)[C@H]1CC(=O)N(CC2CC2)C1.,Cc1ccccc1[C@@H](C)NC(=O)[C@H]1CC(=O)N(CC2CC2)C1,benzene_ring
+123657,Please remove a amine from the molecule O=S(=O)(Cc1ccccc1Cl)NCCc1csc(-c2ccc(F)cc2)n1.,O=S(=O)(Cc1ccccc1Cl)NCCc1csc(-c2ccc(F)cc2)n1,amine
+194796,Remove a benzene_ring from the molecule COc1ccc(/C=C(/CC(=O)Nc2ccc3c(c2)OCO3)c2nc3ccccc3s2)cc1OC.,COc1ccc(/C=C(/CC(=O)Nc2ccc3c(c2)OCO3)c2nc3ccccc3s2)cc1OC,benzene_ring
+74617,Please remove a amide from the molecule CCCc1ccc(-c2nc(NC(=O)c3cccc(S(C)(=O)=O)c3)sc2C)cc1.,CCCc1ccc(-c2nc(NC(=O)c3cccc(S(C)(=O)=O)c3)sc2C)cc1,amide
+206997,Please remove a hydroxyl from the molecule CCC1=NN(C(=O)c2ccncc2)[C@](O)(c2ccc(Cl)cc2)C1.,CCC1=NN(C(=O)c2ccncc2)[C@](O)(c2ccc(Cl)cc2)C1,hydroxyl
+215074,Please remove a benzene_ring from the molecule C[NH2+][C@H](c1ccc(OC(C)C)cc1)c1ncc[nH]1.,C[NH2+][C@H](c1ccc(OC(C)C)cc1)c1ncc[nH]1,benzene_ring
+77717,Remove a amide from the molecule C[C@@H](NC(=O)NCCCC(=O)N(C)C)c1ccc(-c2ccc(F)cc2)cc1.,C[C@@H](NC(=O)NCCCC(=O)N(C)C)c1ccc(-c2ccc(F)cc2)cc1,amide
+185226,Remove a halo from the molecule COc1ccc(Br)cc1CNC(=O)CCl.,COc1ccc(Br)cc1CNC(=O)CCl,halo
+61811,Modify the molecule CCN(Cc1ccccn1)c1ccc(C=O)o1 by removing a aldehyde.,CCN(Cc1ccccn1)c1ccc(C=O)o1,aldehyde
+75178,Remove a nitrile from the molecule CC(C)[C@@H](CO)NC(=O)[C@@H](C#N)Cc1ccccc1.,CC(C)[C@@H](CO)NC(=O)[C@@H](C#N)Cc1ccccc1,nitrile
+73799,Please remove a amide from the molecule CCN(CC(=O)N1CCn2cccc2[C@H]1c1ccccc1Cl)C(=O)C1CCC1.,CCN(CC(=O)N1CCn2cccc2[C@H]1c1ccccc1Cl)C(=O)C1CCC1,amide
+179620,Modify the molecule CCn1c(C(=O)NCCCc2c(C)noc2C)cc2ccccc21 by removing a amide.,CCn1c(C(=O)NCCCc2c(C)noc2C)cc2ccccc21,amide
+175651,Please remove a amide from the molecule CC(C)[C@@H](CO)NC(=O)C(=O)N1C[C@H](C)Oc2ccccc21.,CC(C)[C@@H](CO)NC(=O)C(=O)N1C[C@H](C)Oc2ccccc21,amide
+195373,Modify the molecule CCOc1cccc(CNC(=O)c2cccc(C#N)c2)c1 by removing a nitrile.,CCOc1cccc(CNC(=O)c2cccc(C#N)c2)c1,nitrile
+104768,Remove a hydroxyl from the molecule COC(=O)Cn1cc(C[NH+]2CC[C@@H]([NH+]3CCOCC3)[C@H](O)C2)c2ccccc21.,COC(=O)Cn1cc(C[NH+]2CC[C@@H]([NH+]3CCOCC3)[C@H](O)C2)c2ccccc21,hydroxyl
+3221,Modify the molecule Cc1cc2oc3c(c(=O)c2cc1Cl)[C@H](c1cccnc1)N(CCCN1CCOCC1)C3=O by removing a amide.,Cc1cc2oc3c(c(=O)c2cc1Cl)[C@H](c1cccnc1)N(CCCN1CCOCC1)C3=O,amide
+63614,Please remove a nitrile from the molecule C[C@H](C#N)NC(=O)CCn1ccc2ccccc21.,C[C@H](C#N)NC(=O)CCn1ccc2ccccc21,nitrile
+166229,Please remove a amide from the molecule CCO[C@H](C)C(=O)NC1CCC([NH+]2CCCCC2)CC1.,CCO[C@H](C)C(=O)NC1CCC([NH+]2CCCCC2)CC1,amide
+228539,Modify the molecule COc1ccc([C@@H]2C(C#N)=C(N)O[C@H]3N=NC(C)=C23)c2ccccc12 by removing a nitrile.,COc1ccc([C@@H]2C(C#N)=C(N)O[C@H]3N=NC(C)=C23)c2ccccc12,nitrile
+217312,Remove a amine from the molecule COCCn1c(-c2ccc(C(C)C)cc2)c[nH+]c1N.,COCCn1c(-c2ccc(C(C)C)cc2)c[nH+]c1N,amine
+157230,Please remove a benzene_ring from the molecule Cc1cc(C)n([C@H](C)C(=O)NCc2ccccc2-c2ccc(Cn3ccnc3)cc2)n1.,Cc1cc(C)n([C@H](C)C(=O)NCc2ccccc2-c2ccc(Cn3ccnc3)cc2)n1,benzene_ring
+244724,Please remove a amine from the molecule Nc1cc2[nH]c(=O)[nH]c2cc1S(=O)(=O)[O-].,Nc1cc2[nH]c(=O)[nH]c2cc1S(=O)(=O)[O-],amine
+122638,Remove a amine from the molecule Cc1ccc(S(=O)(=O)/N=C(\[O-])Nc2nnc(C3CC3)s2)cc1.,Cc1ccc(S(=O)(=O)/N=C(\[O-])Nc2nnc(C3CC3)s2)cc1,amine
+43397,Remove a halo from the molecule Cc1nn(C)c2c1nc(CCCl)n2[C@@H](C)[C@@H]1CCCO1.,Cc1nn(C)c2c1nc(CCCl)n2[C@@H](C)[C@@H]1CCCO1,halo
+78415,Please remove a benzene_ring from the molecule O=C(Cc1noc(-c2ccc(-n3ccnn3)cc2)n1)NC1CCCCC1.,O=C(Cc1noc(-c2ccc(-n3ccnn3)cc2)n1)NC1CCCCC1,benzene_ring
+90983,Modify the molecule CCNS(=O)(=O)[C@H]1CCN(C(=O)[C@H]2C[C@@H]2c2sccc2C)C1 by removing a amine.,CCNS(=O)(=O)[C@H]1CCN(C(=O)[C@H]2C[C@@H]2c2sccc2C)C1,amine
+227520,Remove a amine from the molecule O=C(NCc1ccc(N2CCOCC2)c(F)c1)N1CC[C@H](Nc2ccccc2)C1.,O=C(NCc1ccc(N2CCOCC2)c(F)c1)N1CC[C@H](Nc2ccccc2)C1,amine
+169498,Modify the molecule Cc1cccc(OC[C@@H](C)NC(=O)/C=C/C2CC2)c1 by removing a amide.,Cc1cccc(OC[C@@H](C)NC(=O)/C=C/C2CC2)c1,amide
+31939,Please remove a benzene_ring from the molecule Cc1ccc(-n2c(=O)c3sccc3n(Cc3cccc(F)c3)c2=O)cc1.,Cc1ccc(-n2c(=O)c3sccc3n(Cc3cccc(F)c3)c2=O)cc1,benzene_ring
+152017,Modify the molecule CC(C)c1ccccc1NC(=O)CN1C(=O)N[C@@](C)(c2ccccc2)C1=O by removing a amide.,CC(C)c1ccccc1NC(=O)CN1C(=O)N[C@@](C)(c2ccccc2)C1=O,amide
+73347,Remove a benzene_ring from the molecule C[C@@H](NC[C@@H](O)c1cccc(C(F)(F)F)c1)c1cc(F)cc(F)c1.,C[C@@H](NC[C@@H](O)c1cccc(C(F)(F)F)c1)c1cc(F)cc(F)c1,benzene_ring
+36435,Modify the molecule CCOC(=O)/C(=C/c1ccc2c(c1)OCO2)NC(=O)c1cccc([N+](=O)[O-])c1 by removing a amide.,CCOC(=O)/C(=C/c1ccc2c(c1)OCO2)NC(=O)c1cccc([N+](=O)[O-])c1,amide
+215667,Modify the molecule O=C(NCCN1CCOCC1)c1cccc(I)c1 by removing a benzene_ring.,O=C(NCCN1CCOCC1)c1cccc(I)c1,benzene_ring
+230357,Modify the molecule C[C@H]1CC[C@@H](C)CN1C(=O)Nc1cnn(-c2ccccc2S(C)(=O)=O)c1 by removing a benzene_ring.,C[C@H]1CC[C@@H](C)CN1C(=O)Nc1cnn(-c2ccccc2S(C)(=O)=O)c1,benzene_ring
+246869,Remove a benzene_ring from the molecule CCc1noc(-c2ccc(C)c(NC(=O)NCc3ncnn3C)c2)n1.,CCc1noc(-c2ccc(C)c(NC(=O)NCc3ncnn3C)c2)n1,benzene_ring
+142563,Modify the molecule COc1ccc(OC(=O)c2ccccc2-c2cncnc2)cc1F by removing a benzene_ring.,COc1ccc(OC(=O)c2ccccc2-c2cncnc2)cc1F,benzene_ring
+121145,Modify the molecule CN1C(=O)C[C@@H](Nc2ccc(OC(F)F)cn2)[C@@H]1c1ccc(F)cc1 by removing a amide.,CN1C(=O)C[C@@H](Nc2ccc(OC(F)F)cn2)[C@@H]1c1ccc(F)cc1,amide
+77881,Modify the molecule C[C@H]1CN(Cc2ccccc2NC(=O)c2ccncc2F)C[C@H](C)O1 by removing a amide.,C[C@H]1CN(Cc2ccccc2NC(=O)c2ccncc2F)C[C@H](C)O1,amide
+168321,Modify the molecule CC(C)=CC[NH+]1CCC(CCC(=O)Nc2ccccc2)CC1 by removing a benzene_ring.,CC(C)=CC[NH+]1CCC(CCC(=O)Nc2ccccc2)CC1,benzene_ring
+162342,Remove a amide from the molecule CNC(=O)c1c(C)cccc1[N-]S(=O)(=O)c1cc(C)c(F)cc1F.,CNC(=O)c1c(C)cccc1[N-]S(=O)(=O)c1cc(C)c(F)cc1F,amide
+77977,Modify the molecule COc1cc(/C=C2/SC(=S)N([C@H]3CCS(=O)(=O)C3)C2=O)ccc1O by removing a amide.,COc1cc(/C=C2/SC(=S)N([C@H]3CCS(=O)(=O)C3)C2=O)ccc1O,amide
+119212,Modify the molecule CC(=O)N1CCN(C(=O)[C@H](C)[NH+](C)Cc2nc3ccccc3n2C)CC1 by removing a amide.,CC(=O)N1CCN(C(=O)[C@H](C)[NH+](C)Cc2nc3ccccc3n2C)CC1,amide
+15064,Remove a hydroxyl from the molecule COc1ccc(C(=O)N/N=C/c2cc([N+](=O)[O-])ccc2O)cc1OC.,COc1ccc(C(=O)N/N=C/c2cc([N+](=O)[O-])ccc2O)cc1OC,hydroxyl
+234051,Please remove a nitrile from the molecule N#Cc1cccc(NC(=O)c2ccc(C[C@H]3CC(=O)NC3=O)cc2)c1.,N#Cc1cccc(NC(=O)c2ccc(C[C@H]3CC(=O)NC3=O)cc2)c1,nitrile
+13189,Remove a amide from the molecule C[C@H](NC(=O)C(=O)Nc1ccc(F)cc1F)c1cccc(N2CCCC2=O)c1.,C[C@H](NC(=O)C(=O)Nc1ccc(F)cc1F)c1cccc(N2CCCC2=O)c1,amide
+187173,Please remove a amide from the molecule CCc1nnsc1C(=O)N1CC[C@@]2(CCc3ccccc3C(=O)N2)C1.,CCc1nnsc1C(=O)N1CC[C@@]2(CCc3ccccc3C(=O)N2)C1,amide
+153234,Please remove a amide from the molecule COc1ncccc1CNC(=O)c1cc(C2CC2)on1.,COc1ncccc1CNC(=O)c1cc(C2CC2)on1,amide
+146635,Please remove a amine from the molecule Cc1ccc([C@H](C)NC(=O)c2csc(C#CCN)c2)s1.,Cc1ccc([C@H](C)NC(=O)c2csc(C#CCN)c2)s1,amine
+39554,Modify the molecule CC[C@@H](C)N(Cc1c[nH]c2ccccc12)C(=S)Nc1cccc(C)c1 by removing a benzene_ring.,CC[C@@H](C)N(Cc1c[nH]c2ccccc12)C(=S)Nc1cccc(C)c1,benzene_ring
+176346,Modify the molecule C[C@H](OCc1ccccc1)C(=O)NCC(=O)Nc1cccc2ccccc12 by removing a amide.,C[C@H](OCc1ccccc1)C(=O)NCC(=O)Nc1cccc2ccccc12,amide
+58997,Modify the molecule COc1ccc(N2CCN(C(=O)[C@H](C)NC(=O)c3cc4cc(OC)ccc4n3C)CC2)cc1 by removing a benzene_ring.,COc1ccc(N2CCN(C(=O)[C@H](C)NC(=O)c3cc4cc(OC)ccc4n3C)CC2)cc1,benzene_ring
+171159,Modify the molecule COc1ccc(Cc2nnc(SCC(=O)c3ccc(Br)cc3)o2)cc1 by removing a halo.,COc1ccc(Cc2nnc(SCC(=O)c3ccc(Br)cc3)o2)cc1,halo
+125440,Modify the molecule Cc1cccc(CN(C)C(=O)[C@@]2(C(F)(F)F)CC[NH2+]C2)n1 by removing a halo.,Cc1cccc(CN(C)C(=O)[C@@]2(C(F)(F)F)CC[NH2+]C2)n1,halo
+22164,Modify the molecule CCOC(=O)C1CCN(C(=O)c2oc3ccc(S(=O)(=O)N4C[C@H](C)C[C@@H](C)C4)cc3c2C)CC1 by removing a amide.,CCOC(=O)C1CCN(C(=O)c2oc3ccc(S(=O)(=O)N4C[C@H](C)C[C@@H](C)C4)cc3c2C)CC1,amide
+199630,Modify the molecule N#CCSc1cccc(C(=O)N(CC(F)(F)F)c2ccccn2)c1 by removing a benzene_ring.,N#CCSc1cccc(C(=O)N(CC(F)(F)F)c2ccccn2)c1,benzene_ring
+141203,Remove a halo from the molecule C[C@@H](Cl)c1nc2cc(Br)cnc2n1C.,C[C@@H](Cl)c1nc2cc(Br)cnc2n1C,halo
+84976,Modify the molecule CSCC[C@@H](NC(=O)c1ccc2c(c1)OCO2)C(=O)N1CCC2(CC1)NCCc1[nH+]c[nH]c12 by removing a amide.,CSCC[C@@H](NC(=O)c1ccc2c(c1)OCO2)C(=O)N1CCC2(CC1)NCCc1[nH+]c[nH]c12,amide
+75611,Remove a amide from the molecule C[C@H]1CCCCN1C(=O)CNc1ccc(Cl)c([N+](=O)[O-])c1.,C[C@H]1CCCCN1C(=O)CNc1ccc(Cl)c([N+](=O)[O-])c1,amide
+209298,Remove a amide from the molecule Cc1c[nH+]ccc1N1CCCN(C(=O)[C@H]2Cc3ccccc3CN2)CC1.,Cc1c[nH+]ccc1N1CCCN(C(=O)[C@H]2Cc3ccccc3CN2)CC1,amide
+190485,Please remove a benzene_ring from the molecule C[NH2+][C@@H](Cc1ccc(F)cc1Br)[C@H]1CN(C)CCO1.,C[NH2+][C@@H](Cc1ccc(F)cc1Br)[C@H]1CN(C)CCO1,benzene_ring
+195728,Please remove a benzene_ring from the molecule COc1ccc(C)cc1-n1c(SCC2=NC(=O)[C@@H]3SC=CC3=N2)nnc1-c1cccs1.,COc1ccc(C)cc1-n1c(SCC2=NC(=O)[C@@H]3SC=CC3=N2)nnc1-c1cccs1,benzene_ring
+72886,Remove a benzene_ring from the molecule COC(CNc1ccc(Br)c([N+](=O)[O-])c1)OC.,COC(CNc1ccc(Br)c([N+](=O)[O-])c1)OC,benzene_ring
+92339,Please remove a benzene_ring from the molecule CC(C)C[C@@H](C[C@H](O)c1ccccc1)C(=O)[O-].,CC(C)C[C@@H](C[C@H](O)c1ccccc1)C(=O)[O-],benzene_ring
+62393,Modify the molecule O=C(c1cnn(-c2ccccc2)n1)N1CCC(OCc2ccc(F)cc2)CC1 by removing a benzene_ring.,O=C(c1cnn(-c2ccccc2)n1)N1CCC(OCc2ccc(F)cc2)CC1,benzene_ring
+77503,Please remove a halo from the molecule COc1ccc(CNC(=O)Cn2c(=O)c3cccn3c3ccc(F)cc32)cc1OC.,COc1ccc(CNC(=O)Cn2c(=O)c3cccn3c3ccc(F)cc32)cc1OC,halo
+238856,Modify the molecule C[C@H](Oc1ccccc1)C(=O)N(C)[C@H]1CCC[C@@H]1S(C)(=O)=O by removing a benzene_ring.,C[C@H](Oc1ccccc1)C(=O)N(C)[C@H]1CCC[C@@H]1S(C)(=O)=O,benzene_ring
+171059,Modify the molecule C[NH2+][C@H](c1cncc(Br)c1)c1cc(Cl)ccc1OC by removing a halo.,C[NH2+][C@H](c1cncc(Br)c1)c1cc(Cl)ccc1OC,halo
+93809,Remove a amide from the molecule NC(=O)CN1CC2(CCC1=O)CC[NH+](Cc1ncccn1)CC2.,NC(=O)CN1CC2(CCC1=O)CC[NH+](Cc1ncccn1)CC2,amide
+87967,Please remove a amide from the molecule Cc1n[nH]c(C)c1[C@@H]1CCC[NH+]1CC(=O)N1CCC(C(N)=O)CC1.,Cc1n[nH]c(C)c1[C@@H]1CCC[NH+]1CC(=O)N1CCC(C(N)=O)CC1,amide
+210073,Please remove a amide from the molecule C[C@@H](CNC(=O)CS[C@@H]1CCS(=O)(=O)C1)N1C[C@@H](C)O[C@H](C)C1.,C[C@@H](CNC(=O)CS[C@@H]1CCS(=O)(=O)C1)N1C[C@@H](C)O[C@H](C)C1,amide
+38619,Modify the molecule C#C[C@@](C)(CC)NC(=O)Cc1ccccc1 by removing a benzene_ring.,C#C[C@@](C)(CC)NC(=O)Cc1ccccc1,benzene_ring
+29552,Modify the molecule Cc1nc2sc([C@@H](c3ccc(F)cc3)[NH+]3CCC4(CC3)OCCO4)c([O-])n2n1 by removing a halo.,Cc1nc2sc([C@@H](c3ccc(F)cc3)[NH+]3CCC4(CC3)OCCO4)c([O-])n2n1,halo
+196915,Please remove a amide from the molecule CN1C(=O)CSc2ccc(NC(=O)N3CCC([NH+]4CCCCC4)CC3)cc21.,CN1C(=O)CSc2ccc(NC(=O)N3CCC([NH+]4CCCCC4)CC3)cc21,amide
+52231,Please remove a amide from the molecule O=C(Cn1c(=O)oc2ccccc21)NCC1CCN(c2nsc3ccccc23)CC1.,O=C(Cn1c(=O)oc2ccccc21)NCC1CCN(c2nsc3ccccc23)CC1,amide
+43003,Remove a amide from the molecule CCC1(CC)NC(=O)CN(C[C@]2(C)CCCO2)C1=O.,CCC1(CC)NC(=O)CN(C[C@]2(C)CCCO2)C1=O,amide
+143866,Remove a benzene_ring from the molecule CNC(=O)[C@@H]1CCCCN1c1ccc(C#N)c([N+](=O)[O-])c1.,CNC(=O)[C@@H]1CCCCN1c1ccc(C#N)c([N+](=O)[O-])c1,benzene_ring
+162612,Modify the molecule O=S1(=O)CC[C@]2(CC[NH2+]C[C@H]2c2ccccc2Br)C1 by removing a benzene_ring.,O=S1(=O)CC[C@]2(CC[NH2+]C[C@H]2c2ccccc2Br)C1,benzene_ring
+36645,Remove a halo from the molecule CCn1ncnc1C[NH2+][C@@H](C)CCCCl.,CCn1ncnc1C[NH2+][C@@H](C)CCCCl,halo
+110934,Please remove a amide from the molecule COc1ccc(Cl)cc1NC(=O)C(=O)N[C@H](C)C[NH+]1C[C@H](C)C[C@@H](C)C1.,COc1ccc(Cl)cc1NC(=O)C(=O)N[C@H](C)C[NH+]1C[C@H](C)C[C@@H](C)C1,amide
+224616,Remove a amide from the molecule C=CCOc1ccccc1C[NH+](C)CC(=O)N1CCC(O)CC1.,C=CCOc1ccccc1C[NH+](C)CC(=O)N1CCC(O)CC1,amide
+62163,Please remove a amide from the molecule O=C(c1cn2ccsc2n1)N1CCc2c([nH]c3ccccc23)[C@@H]1c1ccccn1.,O=C(c1cn2ccsc2n1)N1CCc2c([nH]c3ccccc23)[C@@H]1c1ccccn1,amide
+171105,Modify the molecule Cc1ccc(NC(=O)Nc2nnc(SCc3ccccc3)s2)cc1 by removing a benzene_ring.,Cc1ccc(NC(=O)Nc2nnc(SCc3ccccc3)s2)cc1,benzene_ring
+9738,Modify the molecule O=C(CCc1cccc(F)c1)Nc1n[nH]c2ccc([N+](=O)[O-])cc12 by removing a benzene_ring.,O=C(CCc1cccc(F)c1)Nc1n[nH]c2ccc([N+](=O)[O-])cc12,benzene_ring
+58511,Remove a amine from the molecule CC(C)(C)NC(=O)CCNS(=O)(=O)c1ccc(Br)cc1.,CC(C)(C)NC(=O)CCNS(=O)(=O)c1ccc(Br)cc1,amine
+237265,Remove a amide from the molecule CC(C)C[C@H](NC(=O)C1CC1)c1cccs1.,CC(C)C[C@H](NC(=O)C1CC1)c1cccs1,amide
+69211,Modify the molecule CC1CCN(C(=O)[C@H]2c3ccccc3CC[NH+]2CC(=O)NCc2ccccc2Cl)CC1 by removing a benzene_ring.,CC1CCN(C(=O)[C@H]2c3ccccc3CC[NH+]2CC(=O)NCc2ccccc2Cl)CC1,benzene_ring
+177937,Remove a benzene_ring from the molecule CCOc1cc(NC(=O)C(=O)N[C@H](C)[C@H]2CCCO2)ccc1C.,CCOc1cc(NC(=O)C(=O)N[C@H](C)[C@H]2CCCO2)ccc1C,benzene_ring
+26896,Remove a nitro from the molecule Cc1ccc([N+](=O)[O-])cc1NC(=O)N(C)CC[NH+](C)C1CCN(C)CC1.,Cc1ccc([N+](=O)[O-])cc1NC(=O)N(C)CC[NH+](C)C1CCN(C)CC1,nitro
+122348,Modify the molecule CCc1nc(NC(=O)[C@@H](C)NC(=O)c2ccccc2Cl)sc1C by removing a halo.,CCc1nc(NC(=O)[C@@H](C)NC(=O)c2ccccc2Cl)sc1C,halo
+137192,Modify the molecule CC(C)[NH+]1CCCN(C(=O)CCNC(=O)c2ccc(F)cc2Cl)CC1 by removing a amide.,CC(C)[NH+]1CCCN(C(=O)CCNC(=O)c2ccc(F)cc2Cl)CC1,amide
+5804,Remove a nitrile from the molecule Cc1sc(NC(=O)c2cc(Br)cs2)c(C#N)c1C.,Cc1sc(NC(=O)c2cc(Br)cs2)c(C#N)c1C,nitrile
+159339,Modify the molecule O=C([O-])[C@H]1C[C@H](O)CN1C(=O)c1ccccc1O by removing a hydroxyl.,O=C([O-])[C@H]1C[C@H](O)CN1C(=O)c1ccccc1O,hydroxyl
+120100,Please remove a benzene_ring from the molecule Cc1cc(C(=O)NCC(C)C)ccc1NC(=O)c1cnn(C(C)C)c1C.,Cc1cc(C(=O)NCC(C)C)ccc1NC(=O)c1cnn(C(C)C)c1C,benzene_ring
+71980,Modify the molecule Cc1cccc(C)c1OC1CCN(C(=O)[C@H](C)c2cccs2)CC1 by removing a amide.,Cc1cccc(C)c1OC1CCN(C(=O)[C@H](C)c2cccs2)CC1,amide
+247324,Modify the molecule C[C@H]1[C@H](C(=O)[O-])CCN1C(=O)Nc1ccc(F)cc1 by removing a benzene_ring.,C[C@H]1[C@H](C(=O)[O-])CCN1C(=O)Nc1ccc(F)cc1,benzene_ring
+204098,Modify the molecule Cc1c(NC(=O)c2cccc3cc[nH]c23)cccc1C(=O)N1CCCC1 by removing a amide.,Cc1c(NC(=O)c2cccc3cc[nH]c23)cccc1C(=O)N1CCCC1,amide
+30006,Modify the molecule O=C(Nc1ccccc1I)C1CCN(S(=O)(=O)c2ccccc2F)CC1 by removing a benzene_ring.,O=C(Nc1ccccc1I)C1CCN(S(=O)(=O)c2ccccc2F)CC1,benzene_ring
+202346,Please remove a amide from the molecule Cc1cccc(OCC(=O)NC[C@H](c2ccc(C)o2)[NH+]2CCCCC2)c1.,Cc1cccc(OCC(=O)NC[C@H](c2ccc(C)o2)[NH+]2CCCCC2)c1,amide
+30122,Please remove a nitro from the molecule O=C(C1CCCC1)N1CCN(S(=O)(=O)c2ccc([N+](=O)[O-])s2)CC1.,O=C(C1CCCC1)N1CCN(S(=O)(=O)c2ccc([N+](=O)[O-])s2)CC1,nitro
+109745,Modify the molecule O=C(c1csnn1)N1CCO[C@@H](c2ccc(Cl)cc2)C1 by removing a amide.,O=C(c1csnn1)N1CCO[C@@H](c2ccc(Cl)cc2)C1,amide
+211595,Modify the molecule Nc1cc(Cl)c([N+](=O)[O-])cc1COc1ccccc1 by removing a nitro.,Nc1cc(Cl)c([N+](=O)[O-])cc1COc1ccccc1,nitro
+10193,Remove a halo from the molecule Cc1cccc(C(=O)NN2Cc3ccccc3C2)c1F.,Cc1cccc(C(=O)NN2Cc3ccccc3C2)c1F,halo
+226112,Remove a amine from the molecule COc1ccc(O)c([C@@H](C)Nc2ccc(F)cc2[N+](=O)[O-])c1.,COc1ccc(O)c([C@@H](C)Nc2ccc(F)cc2[N+](=O)[O-])c1,amine
+198343,Remove a benzene_ring from the molecule C[C@H](Oc1ccccc1Br)C(=O)N/N=C\c1cc(Cl)ccc1[N+](=O)[O-].,C[C@H](Oc1ccccc1Br)C(=O)N/N=C\c1cc(Cl)ccc1[N+](=O)[O-],benzene_ring
+85850,Please remove a amide from the molecule COc1ccnc(NNC(=O)c2cccc(C#N)c2)n1.,COc1ccnc(NNC(=O)c2cccc(C#N)c2)n1,amide
+139437,Remove a amide from the molecule CCOC(=O)[C@H](CC)N1CCC(C(=O)N2CCCCCC2)CC1.,CCOC(=O)[C@H](CC)N1CCC(C(=O)N2CCCCCC2)CC1,amide
+29121,Modify the molecule COc1cc([C@@H]2Nc3ccccc3C3=[NH+]CCCN32)cc(OC)c1OC by removing a amine.,COc1cc([C@@H]2Nc3ccccc3C3=[NH+]CCCN32)cc(OC)c1OC,amine
+168852,Remove a benzene_ring from the molecule CC[C@@H](NC(=O)N1CCN(C(=O)C2CCCCC2)CC1)c1ccc(OC)cc1.,CC[C@@H](NC(=O)N1CCN(C(=O)C2CCCCC2)CC1)c1ccc(OC)cc1,benzene_ring
+171130,Remove a amide from the molecule Cc1cccc(C2=CCN(C(=O)NNC(=O)c3ccccc3)CC2)c1.,Cc1cccc(C2=CCN(C(=O)NNC(=O)c3ccccc3)CC2)c1,amide
+75682,Modify the molecule CC(=O)C1=C(Nc2ccc(C)cc2)C[C@](C)(O)[C@H](C(C)=O)[C@H]1c1ccc(Cl)cc1 by removing a halo.,CC(=O)C1=C(Nc2ccc(C)cc2)C[C@](C)(O)[C@H](C(C)=O)[C@H]1c1ccc(Cl)cc1,halo
+217021,Please remove a benzene_ring from the molecule O=C(NC1CCCCC1)[C@H](c1ccc(F)cc1)N(C(=O)c1cnccn1)c1ccccc1F.,O=C(NC1CCCCC1)[C@H](c1ccc(F)cc1)N(C(=O)c1cnccn1)c1ccccc1F,benzene_ring
+5221,Please remove a amine from the molecule C[C@@H](CNCc1ccc(Cl)nc1)[NH+](C)Cc1ccccc1.,C[C@@H](CNCc1ccc(Cl)nc1)[NH+](C)Cc1ccccc1,amine
+106216,Remove a amide from the molecule CCCCn1c(SCC(=O)N(C)C2CCCCC2)nc2cc(C)[nH]c2c1=O.,CCCCn1c(SCC(=O)N(C)C2CCCCC2)nc2cc(C)[nH]c2c1=O,amide
+20529,Modify the molecule CCc1ccccc1NC(=O)N[C@H](C)C(=O)N1CCCC[C@@H]1C by removing a benzene_ring.,CCc1ccccc1NC(=O)N[C@H](C)C(=O)N1CCCC[C@@H]1C,benzene_ring
+76756,Modify the molecule COc1ccc(-n2c(=S)[nH]c3ccc(C)cc32)c(C)c1 by removing a benzene_ring.,COc1ccc(-n2c(=S)[nH]c3ccc(C)cc32)c(C)c1,benzene_ring
+142063,Modify the molecule COc1ccc(NC(=O)c2cccc(OC(C)=O)c2)cc1OC by removing a amide.,COc1ccc(NC(=O)c2cccc(OC(C)=O)c2)cc1OC,amide
+155984,Modify the molecule Cc1cccc2c(N3CCCN(S(C)(=O)=O)CC3)c(C#N)cnc12 by removing a nitrile.,Cc1cccc2c(N3CCCN(S(C)(=O)=O)CC3)c(C#N)cnc12,nitrile
+149549,Modify the molecule Cc1ccc(Cl)cc1NC(=O)C[C@H]1CSc2nc3c(cnn3-c3ccccc3)c(=O)n21 by removing a halo.,Cc1ccc(Cl)cc1NC(=O)C[C@H]1CSc2nc3c(cnn3-c3ccccc3)c(=O)n21,halo
+113524,Modify the molecule Cc1ccc(CNC(=O)/C=C/c2cccc(C)c2)cc1 by removing a amide.,Cc1ccc(CNC(=O)/C=C/c2cccc(C)c2)cc1,amide
+85190,Please remove a amide from the molecule Cc1cccc(CC(=O)N2CCC3(CCC(=O)N([C@H](C)C(=O)[O-])C3)CC2)c1.,Cc1cccc(CC(=O)N2CCC3(CCC(=O)N([C@H](C)C(=O)[O-])C3)CC2)c1,amide
+109900,Remove a benzene_ring from the molecule Cc1ccc(C(C)C)cc1OCC(=O)N(C)[C@@H](C)c1ccc(-n2cncn2)cc1.,Cc1ccc(C(C)C)cc1OCC(=O)N(C)[C@@H](C)c1ccc(-n2cncn2)cc1,benzene_ring
+131292,Modify the molecule Brc1cnc(N2CCCC2)cn1 by removing a halo.,Brc1cnc(N2CCCC2)cn1,halo
+46376,Remove a amide from the molecule CCSCC[C@H](C)N(C)C(=O)c1cc(=O)c2ccccc2o1.,CCSCC[C@H](C)N(C)C(=O)c1cc(=O)c2ccccc2o1,amide
+35558,Please remove a benzene_ring from the molecule Cc1ccc(C(=O)NCc2cscn2)cc1NC(=O)Nc1ccccc1.,Cc1ccc(C(=O)NCc2cscn2)cc1NC(=O)Nc1ccccc1,benzene_ring
+158899,Remove a benzene_ring from the molecule O=C(Cn1ncc2c3ccccc3n(Cc3cccc(Cl)c3)c2c1=O)N1CCC2(CC1)OCCO2.,O=C(Cn1ncc2c3ccccc3n(Cc3cccc(Cl)c3)c2c1=O)N1CCC2(CC1)OCCO2,benzene_ring
+87843,Modify the molecule COc1cccc([C@H]2[C@H]3[NH+]=c4ccccc4=C3CCN2Cc2cnn(C)c2C)c1 by removing a amine.,COc1cccc([C@H]2[C@H]3[NH+]=c4ccccc4=C3CCN2Cc2cnn(C)c2C)c1,amine
+71760,Please remove a nitrile from the molecule CC1(C)CC(=O)C2=C(C1)OC(N)=C(C#N)[C@H]2c1ccc(C(C)(C)C)s1.,CC1(C)CC(=O)C2=C(C1)OC(N)=C(C#N)[C@H]2c1ccc(C(C)(C)C)s1,nitrile
+65229,Modify the molecule O=C(Nc1cccc(-c2nnco2)c1)c1cn(-c2ccccc2)nc1-c1cccs1 by removing a benzene_ring.,O=C(Nc1cccc(-c2nnco2)c1)c1cn(-c2ccccc2)nc1-c1cccs1,benzene_ring
+94796,Modify the molecule CCOc1ccc(Oc2cncc(C[NH3+])n2)cc1 by removing a benzene_ring.,CCOc1ccc(Oc2cncc(C[NH3+])n2)cc1,benzene_ring
+63016,Modify the molecule O=C([O-])c1cnc(Nc2ccccc2)nc1 by removing a benzene_ring.,O=C([O-])c1cnc(Nc2ccccc2)nc1,benzene_ring
+137343,Remove a amide from the molecule Cc1ncccc1C(=O)N[C@H](C(N)=S)C(C)C.,Cc1ncccc1C(=O)N[C@H](C(N)=S)C(C)C,amide
+128206,Modify the molecule C[C@H]1[NH2+]CC[C@H]1C(=O)N(C)Cc1cc(C#N)ccc1F by removing a amide.,C[C@H]1[NH2+]CC[C@H]1C(=O)N(C)Cc1cc(C#N)ccc1F,amide
+209129,Please remove a amide from the molecule CCc1ccc(C(=O)N2CCC[C@@H](c3cc(C(N)=O)[nH]n3)C2)o1.,CCc1ccc(C(=O)N2CCC[C@@H](c3cc(C(N)=O)[nH]n3)C2)o1,amide
+198510,Modify the molecule Cc1ccc(N)c(SC[C@@H](C)CO)c1 by removing a amine.,Cc1ccc(N)c(SC[C@@H](C)CO)c1,amine
+119998,Please remove a halo from the molecule COc1cc(NC(=O)c2ccccc2C(F)(F)F)cc(OC)c1.,COc1cc(NC(=O)c2ccccc2C(F)(F)F)cc(OC)c1,halo
+178854,Please remove a halo from the molecule CO[C@@H](C)C(=O)NNc1ccccc1C(F)(F)F.,CO[C@@H](C)C(=O)NNc1ccccc1C(F)(F)F,halo
+211901,Remove a benzene_ring from the molecule CC(=O)Nc1ccc(C(C)=O)cc1OCc1ccc(Br)cc1.,CC(=O)Nc1ccc(C(C)=O)cc1OCc1ccc(Br)cc1,benzene_ring
+144533,Modify the molecule Cn1ccnc(NCCSCc2ccc(Cl)cc2Cl)c1=O by removing a amine.,Cn1ccnc(NCCSCc2ccc(Cl)cc2Cl)c1=O,amine
+98161,Modify the molecule O=C(Nc1ccc(Nc2ccccc2)cc1)c1ccc(O)nc1 by removing a amine.,O=C(Nc1ccc(Nc2ccccc2)cc1)c1ccc(O)nc1,amine
+62030,Please remove a amide from the molecule CCC(=O)Oc1ccc(C(=O)Nc2cc(Cl)ccc2C(=O)[O-])cc1.,CCC(=O)Oc1ccc(C(=O)Nc2cc(Cl)ccc2C(=O)[O-])cc1,amide
+130742,Modify the molecule CCN(Cc1ccccn1)C(=O)[C@H]1C[NH2+]C[C@@H]1C by removing a amide.,CCN(Cc1ccccn1)C(=O)[C@H]1C[NH2+]C[C@@H]1C,amide
+120102,Please remove a amide from the molecule CC[C@H](C)NC(=O)c1ccc(Cl)c(S(=O)(=O)N2CCN(C)CC2)c1.,CC[C@H](C)NC(=O)c1ccc(Cl)c(S(=O)(=O)N2CCN(C)CC2)c1,amide
+141485,Modify the molecule Cc1cccc(OC(=O)CCCN2C(=O)NC3(CCCC3)C2=O)c1 by removing a benzene_ring.,Cc1cccc(OC(=O)CCCN2C(=O)NC3(CCCC3)C2=O)c1,benzene_ring
+214155,Please remove a amide from the molecule N#CCc1ccccc1C(=O)OCC(=O)NCc1cccs1.,N#CCc1ccccc1C(=O)OCC(=O)NCc1cccs1,amide
+210127,Please remove a benzene_ring from the molecule CCc1cccc(C(=O)N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c1O.,CCc1cccc(C(=O)N2CCN(Cc3cccc([N+](=O)[O-])c3)CC2)c1O,benzene_ring
+143704,Remove a benzene_ring from the molecule C[C@H]1CCCCN1S(=O)(=O)c1ccc(C(=O)N(C)Cc2ccc(F)cc2)cc1.,C[C@H]1CCCCN1S(=O)(=O)c1ccc(C(=O)N(C)Cc2ccc(F)cc2)cc1,benzene_ring
+75330,Please remove a halo from the molecule COc1cc(OC)cc(-c2nnc(SCc3ccc(F)cc3)o2)c1.,COc1cc(OC)cc(-c2nnc(SCc3ccc(F)cc3)o2)c1,halo
+12008,Please remove a hydroxyl from the molecule Cc1ccccc1C(=O)NCCC(=O)NC[C@H](O)c1ccc(Cl)cc1.,Cc1ccccc1C(=O)NCCC(=O)NC[C@H](O)c1ccc(Cl)cc1,hydroxyl
+182920,Remove a amide from the molecule CN(Cc1csc2ccccc12)C(=O)NCc1cccc(C(N)=O)c1.,CN(Cc1csc2ccccc12)C(=O)NCc1cccc(C(N)=O)c1,amide
+168029,Remove a halo from the molecule COc1cc(C(=O)Nc2nc3c(C)cccc3s2)cc(Cl)c1OC.,COc1cc(C(=O)Nc2nc3c(C)cccc3s2)cc(Cl)c1OC,halo
+132630,Remove a benzene_ring from the molecule C[NH+]1[C@H]2CC[C@@H]1CN(C(=O)NCCCS(=O)(=O)c1ccccc1)CC2.,C[NH+]1[C@H]2CC[C@@H]1CN(C(=O)NCCCS(=O)(=O)c1ccccc1)CC2,benzene_ring
+247824,Modify the molecule CCNC(=O)C1CC[NH+]([C@@H](C)c2cccc(C)c2)CC1 by removing a amide.,CCNC(=O)C1CC[NH+]([C@@H](C)c2cccc(C)c2)CC1,amide
+176970,Modify the molecule Cn1ncc2c1CCC[C@H]2N[C@H]1C[NH+]2CCC1CC2 by removing a amine.,Cn1ncc2c1CCC[C@H]2N[C@H]1C[NH+]2CCC1CC2,amine
+151547,Modify the molecule Cc1cnoc1-c1ccc(C#N)cc1 by removing a nitrile.,Cc1cnoc1-c1ccc(C#N)cc1,nitrile
+52539,Remove a hydroxyl from the molecule Cc1c(C[NH2+][C@H]2CCC[C@@H](O)C2)cnn1C.,Cc1c(C[NH2+][C@H]2CCC[C@@H](O)C2)cnn1C,hydroxyl
+230914,Please remove a benzene_ring from the molecule Cc1noc(C)c1[C@@H](C)CN[C@H](C)c1ccc(C(C)C)cc1.,Cc1noc(C)c1[C@@H](C)CN[C@H](C)c1ccc(C(C)C)cc1,benzene_ring
+58395,Please remove a halo from the molecule CCOC(=O)c1cccc(NC(=O)c2ccccc2F)c1.,CCOC(=O)c1cccc(NC(=O)c2ccccc2F)c1,halo
+144220,Remove a amide from the molecule Cc1ccc(OCn2ccc(C(=O)N[C@@H](C)c3cn(C)nc3C)n2)c(C)c1.,Cc1ccc(OCn2ccc(C(=O)N[C@@H](C)c3cn(C)nc3C)n2)c(C)c1,amide
+109067,Please remove a amide from the molecule CCCC(=O)N1CCc2[nH]nc(C(=O)NCc3ccc4c(c3)OCO4)c2C1.,CCCC(=O)N1CCc2[nH]nc(C(=O)NCc3ccc4c(c3)OCO4)c2C1,amide
+129929,Please remove a benzene_ring from the molecule Cc1ccc(C2=[NH+]CCN2)c(O)c1.,Cc1ccc(C2=[NH+]CCN2)c(O)c1,benzene_ring
+45255,Please remove a halo from the molecule CN(C)C(=O)NCC(=O)N1CCc2[nH]nc(-c3ccc(F)c(F)c3)c2C1.,CN(C)C(=O)NCC(=O)N1CCc2[nH]nc(-c3ccc(F)c(F)c3)c2C1,halo
+40026,Please remove a benzene_ring from the molecule Cc1ccc(C(=O)CN2C(=O)N[C@@](C)(c3ccccc3Br)C2=O)cc1.,Cc1ccc(C(=O)CN2C(=O)N[C@@](C)(c3ccccc3Br)C2=O)cc1,benzene_ring
+240715,Modify the molecule CCCOCC(=O)N[C@H](C)c1cnn(-c2cccc3ccccc23)c1C by removing a amide.,CCCOCC(=O)N[C@H](C)c1cnn(-c2cccc3ccccc23)c1C,amide
+8321,Remove a amide from the molecule CC(C)(C)N1C[C@H](NC(=O)NC[C@@](C)(O)c2ccccc2)CC1=O.,CC(C)(C)N1C[C@H](NC(=O)NC[C@@](C)(O)c2ccccc2)CC1=O,amide
+89151,Modify the molecule O=C(NC[C@H](O)c1ccco1)c1ccc(SC(F)F)cc1 by removing a halo.,O=C(NC[C@H](O)c1ccco1)c1ccc(SC(F)F)cc1,halo
+88437,Please remove a benzene_ring from the molecule CC1=NN(c2ccccc2)C(=O)/C1=C\c1ccc(OCC(=O)[O-])cc1.,CC1=NN(c2ccccc2)C(=O)/C1=C\c1ccc(OCC(=O)[O-])cc1,benzene_ring
+59307,Remove a halo from the molecule CCOc1ccccc1N1CC[NH+](Cc2nnsc2Cl)CC1.,CCOc1ccccc1N1CC[NH+](Cc2nnsc2Cl)CC1,halo
+141912,Remove a halo from the molecule C[C@@H](CCc1ccco1)[NH2+]Cc1ncccc1F.,C[C@@H](CCc1ccco1)[NH2+]Cc1ncccc1F,halo
+82951,Please remove a halo from the molecule NC(=O)CN1CCN(C(=O)C[C@@H](O)c2ccc(Cl)cc2)CC1.,NC(=O)CN1CCN(C(=O)C[C@@H](O)c2ccc(Cl)cc2)CC1,halo
+180213,Modify the molecule C[C@@H](NC(=O)Nc1cccc2c1OCCO2)c1ccc(OC(F)F)cc1 by removing a benzene_ring.,C[C@@H](NC(=O)Nc1cccc2c1OCCO2)c1ccc(OC(F)F)cc1,benzene_ring
+216873,Modify the molecule COc1ccccc1C(=O)N1CCN(C(=O)Cc2c(C)noc2C)CC1 by removing a benzene_ring.,COc1ccccc1C(=O)N1CCN(C(=O)Cc2c(C)noc2C)CC1,benzene_ring
+95366,Remove a amide from the molecule COCCC(=O)N1CCN(S(=O)(=O)c2cnc(-c3ccccn3)nc2C)CC1.,COCCC(=O)N1CCN(S(=O)(=O)c2cnc(-c3ccccn3)nc2C)CC1,amide
+6764,Remove a benzene_ring from the molecule CCOc1ccc(O[C@H](C)C(=O)Nc2ccc(C)cc2Br)cc1.,CCOc1ccc(O[C@H](C)C(=O)Nc2ccc(C)cc2Br)cc1,benzene_ring
+100925,Modify the molecule COc1ccc(-n2c(C)nc3nc([NH+]4CCCC4)nc([O-])c3c2=S)cc1 by removing a benzene_ring.,COc1ccc(-n2c(C)nc3nc([NH+]4CCCC4)nc([O-])c3c2=S)cc1,benzene_ring
+98314,Please remove a hydroxyl from the molecule CCS[C@@H]1CCC[C@](CO)([NH2+]C(C)C)C1.,CCS[C@@H]1CCC[C@](CO)([NH2+]C(C)C)C1,hydroxyl
+76499,Please remove a benzene_ring from the molecule COc1ccc2c(c1)CCCN2CC(=O)NCC(=O)Nc1ccc(F)c(F)c1.,COc1ccc2c(c1)CCCN2CC(=O)NCC(=O)Nc1ccc(F)c(F)c1,benzene_ring
+220252,Remove a amide from the molecule CC(C)CCN1C[C@@H](C(=O)Nc2ccc3cc[nH]c3c2)CC1=O.,CC(C)CCN1C[C@@H](C(=O)Nc2ccc3cc[nH]c3c2)CC1=O,amide
+4828,Remove a nitrile from the molecule CCOc1ccccc1[C@H]1C(C#N)=C(SCC(=O)Nc2cc(C)ccc2C)N=C2CCCC(=O)[C@@H]21.,CCOc1ccccc1[C@H]1C(C#N)=C(SCC(=O)Nc2cc(C)ccc2C)N=C2CCCC(=O)[C@@H]21,nitrile
+34195,Modify the molecule CCn1ccnc1SCC(=O)N1CCO[C@@H]2CCCC[C@H]21 by removing a amide.,CCn1ccnc1SCC(=O)N1CCO[C@@H]2CCCC[C@H]21,amide
+221792,Modify the molecule N#Cc1c(NC(=O)CCCc2nc(-c3ccccc3)no2)sc2c1CCCC2 by removing a benzene_ring.,N#Cc1c(NC(=O)CCCc2nc(-c3ccccc3)no2)sc2c1CCCC2,benzene_ring
+207389,Remove a benzene_ring from the molecule CCc1ccc(NC(=O)N2CCOc3ccccc32)cc1.,CCc1ccc(NC(=O)N2CCOc3ccccc32)cc1,benzene_ring
+244295,Modify the molecule O=C(Nc1cc(F)ccc1Cl)[C@@H]1CCCN1C(=O)c1cccs1 by removing a amide.,O=C(Nc1cc(F)ccc1Cl)[C@@H]1CCCN1C(=O)c1cccs1,amide
+166534,Remove a halo from the molecule O=C(C[NH2+]CCc1ccccc1)Nc1ccc(Cl)c(Cl)c1.,O=C(C[NH2+]CCc1ccccc1)Nc1ccc(Cl)c(Cl)c1,halo
+25242,Modify the molecule O=C(NC(=S)Nc1ccccn1)c1ccc(Cl)cc1 by removing a halo.,O=C(NC(=S)Nc1ccccn1)c1ccc(Cl)cc1,halo
+133764,Remove a hydroxyl from the molecule O=C1/C(=C/c2ccc3ccccc3n2)Oc2cc(O)ccc21.,O=C1/C(=C/c2ccc3ccccc3n2)Oc2cc(O)ccc21,hydroxyl
+58584,Modify the molecule CC[NH2+]Cc1cnn(-c2cccc(Br)c2)c1C1CC1 by removing a benzene_ring.,CC[NH2+]Cc1cnn(-c2cccc(Br)c2)c1C1CC1,benzene_ring
+82880,Remove a hydroxyl from the molecule CC[C@](C)(C[NH3+])[C@H](O)CCc1ccccc1.,CC[C@](C)(C[NH3+])[C@H](O)CCc1ccccc1,hydroxyl
+133652,Please remove a amide from the molecule CC(=O)NCCNC(=O)/C=C/c1cc(C(F)(F)F)ccc1Cl.,CC(=O)NCCNC(=O)/C=C/c1cc(C(F)(F)F)ccc1Cl,amide
+211492,Please remove a benzene_ring from the molecule C[C@H]1C[C@@H]1C(=O)NC[C@@H](C)Sc1ccc(Br)cc1.,C[C@H]1C[C@@H]1C(=O)NC[C@@H](C)Sc1ccc(Br)cc1,benzene_ring
+52436,Remove a benzene_ring from the molecule O=C(Cc1cccc(F)c1F)c1cc(Cl)ccc1F.,O=C(Cc1cccc(F)c1F)c1cc(Cl)ccc1F,benzene_ring
+111231,Remove a amide from the molecule CC(=O)N[C@H]1[C@H](OC2=C[C@H]3OC(=O)C=C(C)[C@H]3C=C2)O[C@H](CO)[C@@H](O)[C@@H]1O.,CC(=O)N[C@H]1[C@H](OC2=C[C@H]3OC(=O)C=C(C)[C@H]3C=C2)O[C@H](CO)[C@@H](O)[C@@H]1O,amide
+10166,Please remove a amide from the molecule COc1nn(C)cc1C(=O)NCC1CCN(C(=O)c2cccnc2SC)CC1.,COc1nn(C)cc1C(=O)NCC1CCN(C(=O)c2cccnc2SC)CC1,amide
+84888,Remove a halo from the molecule Cc1ccc(Cl)cc1NC(=O)CNc1ccc(S(=O)(=O)N2CCCCC2)cc1.,Cc1ccc(Cl)cc1NC(=O)CNc1ccc(S(=O)(=O)N2CCCCC2)cc1,halo
+186235,Modify the molecule O=C1NCC=Cc2c1[nH]c(Br)c2Br by removing a halo.,O=C1NCC=Cc2c1[nH]c(Br)c2Br,halo
+112751,Remove a benzene_ring from the molecule COc1ccc(F)cc1C(=O)COC(=O)c1csc(-c2ccc(C)cc2)n1.,COc1ccc(F)cc1C(=O)COC(=O)c1csc(-c2ccc(C)cc2)n1,benzene_ring
+48767,Remove a amine from the molecule O=C(Nc1cc(Cl)ccc1O)c1cc2n(n1)[C@@H](C(F)(F)F)C[C@H](c1ccc3c(c1)OCO3)N2.,O=C(Nc1cc(Cl)ccc1O)c1cc2n(n1)[C@@H](C(F)(F)F)C[C@H](c1ccc3c(c1)OCO3)N2,amine
+218466,Please remove a benzene_ring from the molecule COc1ccc([C@H]2[C@@H]3SC(=O)N=C3S[C@@H](C(=O)[O-])[C@H]2C(=O)c2ccc3c(c2)CCCC3)cc1.,COc1ccc([C@H]2[C@@H]3SC(=O)N=C3S[C@@H](C(=O)[O-])[C@H]2C(=O)c2ccc3c(c2)CCCC3)cc1,benzene_ring
+110805,Modify the molecule CCC(=O)Nc1ccc(NC(=O)NCCc2cccs2)cc1C by removing a amide.,CCC(=O)Nc1ccc(NC(=O)NCCc2cccs2)cc1C,amide
+233134,Modify the molecule COc1ccc(N2C(=O)/C(=C/c3cn(-c4ccccc4)nc3-c3ccccc3)SC2=S)cc1 by removing a amide.,COc1ccc(N2C(=O)/C(=C/c3cn(-c4ccccc4)nc3-c3ccccc3)SC2=S)cc1,amide
+11003,Remove a benzene_ring from the molecule COc1ccc(CN2CC[NH+](Cn3nc(C4CC4)n(C)c3=S)CC2)cc1.,COc1ccc(CN2CC[NH+](Cn3nc(C4CC4)n(C)c3=S)CC2)cc1,benzene_ring
+115435,Please remove a amide from the molecule CCOC(=O)[C@H]1CCCN(C(=O)c2ccc(C)nc2)C1.,CCOC(=O)[C@H]1CCCN(C(=O)c2ccc(C)nc2)C1,amide
+219959,Modify the molecule C#CCOc1ccc(/C=C2/C(=O)NN(c3cc(Cl)cc(Cl)c3)C2=O)cc1OCC by removing a amide.,C#CCOc1ccc(/C=C2/C(=O)NN(c3cc(Cl)cc(Cl)c3)C2=O)cc1OCC,amide
+172486,Modify the molecule O=C1CC[C@@H](Cn2c(CCCl)nc3cccnc32)N1 by removing a halo.,O=C1CC[C@@H](Cn2c(CCCl)nc3cccnc32)N1,halo
+38296,Remove a amide from the molecule COc1ccc2cc(C(=O)NCc3cccc(NC(=O)N4CCCC4)c3)[nH]c2c1.,COc1ccc2cc(C(=O)NCc3cccc(NC(=O)N4CCCC4)c3)[nH]c2c1,amide
+119671,Modify the molecule C[C@@H]1C[C@@H]1n1c(CCCl)nc2cc(Br)cnc21 by removing a halo.,C[C@@H]1C[C@@H]1n1c(CCCl)nc2cc(Br)cnc21,halo
+153105,Modify the molecule N#Cc1cccc(NC(=O)CN2c3cccc4cccc(c34)S2(=O)=O)c1 by removing a benzene_ring.,N#Cc1cccc(NC(=O)CN2c3cccc4cccc(c34)S2(=O)=O)c1,benzene_ring
+88532,Modify the molecule CCn1cc(C[NH+](CC2CC2)[C@H](C)c2ccccc2)cn1 by removing a benzene_ring.,CCn1cc(C[NH+](CC2CC2)[C@H](C)c2ccccc2)cn1,benzene_ring
+224456,Modify the molecule CC[NH+]1CCCN(C(=O)[C@@H]2CCC(=O)N(c3ccc(C)c(C)c3)C2)CC1 by removing a benzene_ring.,CC[NH+]1CCCN(C(=O)[C@@H]2CCC(=O)N(c3ccc(C)c(C)c3)C2)CC1,benzene_ring
+67007,Remove a benzene_ring from the molecule CC[C@H](C)N(C)C(=O)Nc1ccc(N(C)C)cc1.,CC[C@H](C)N(C)C(=O)Nc1ccc(N(C)C)cc1,benzene_ring
+175371,Modify the molecule COC(=O)[C@H](O)C1CC[NH+](CC2=Cc3ccccc3OC2)CC1 by removing a hydroxyl.,COC(=O)[C@H](O)C1CC[NH+](CC2=Cc3ccccc3OC2)CC1,hydroxyl
+146953,Please remove a benzene_ring from the molecule Cc1csc(S[C@H](C)C(=O)NC(c2ccccc2)c2ccccc2)n1.,Cc1csc(S[C@H](C)C(=O)NC(c2ccccc2)c2ccccc2)n1,benzene_ring
+98587,Remove a amide from the molecule CNC(=O)c1sc2ccccc2c1[C@H]1CCN(C(=O)c2cccc(N(C)C)c2)C1.,CNC(=O)c1sc2ccccc2c1[C@H]1CCN(C(=O)c2cccc(N(C)C)c2)C1,amide
+230603,Remove a amide from the molecule Cc1ccc(-n2c(SCC(=O)N3CCC(C)CC3)nc3[nH]nc(C)c3c2=[NH2+])cc1.,Cc1ccc(-n2c(SCC(=O)N3CCC(C)CC3)nc3[nH]nc(C)c3c2=[NH2+])cc1,amide
+225188,Please remove a amide from the molecule CN(C(=O)c1ccccc1NC(=O)/C=C/c1ccc(Cl)cc1)C1CCCCC1.,CN(C(=O)c1ccccc1NC(=O)/C=C/c1ccc(Cl)cc1)C1CCCCC1,amide
+63245,Modify the molecule Cc1ccc(C(C)(C)C)cc1[S@@](=O)Cc1cn2ccccc2n1 by removing a benzene_ring.,Cc1ccc(C(C)(C)C)cc1[S@@](=O)Cc1cn2ccccc2n1,benzene_ring
+226737,Modify the molecule CN(C)C(=O)[C@@H](OC(=O)CCn1nnc2ccccc2c1=O)c1ccccc1 by removing a benzene_ring.,CN(C)C(=O)[C@@H](OC(=O)CCn1nnc2ccccc2c1=O)c1ccccc1,benzene_ring
+126672,Remove a amide from the molecule CC(C)NC(=O)C[C@H](C)NC(=O)N(C)[C@@H]1CCc2ccccc2C1.,CC(C)NC(=O)C[C@H](C)NC(=O)N(C)[C@@H]1CCc2ccccc2C1,amide
+141863,Please remove a amide from the molecule CCCN1C(=O)C([O-])=C(C(C)=O)[C@H]1c1ccccc1.,CCCN1C(=O)C([O-])=C(C(C)=O)[C@H]1c1ccccc1,amide
+14303,Remove a benzene_ring from the molecule COCC(=O)N[C@H](C)c1nc2ccccc2n1Cc1ccc(F)cc1.,COCC(=O)N[C@H](C)c1nc2ccccc2n1Cc1ccc(F)cc1,benzene_ring
+52898,Remove a hydroxyl from the molecule CCC[NH+]1CCN([C@H]2CC[C@@](CO)([NH2+]C(C)C)C2)CC1.,CCC[NH+]1CCN([C@H]2CC[C@@](CO)([NH2+]C(C)C)C2)CC1,hydroxyl
+162454,Modify the molecule COc1cccc(-n2cc(C(=O)[O-])c3c2[C@H](c2cc(OC)c(OC)c(OC)c2)CC(=O)N3)c1 by removing a benzene_ring.,COc1cccc(-n2cc(C(=O)[O-])c3c2[C@H](c2cc(OC)c(OC)c(OC)c2)CC(=O)N3)c1,benzene_ring
+175837,Remove a benzene_ring from the molecule [NH3+][C@H](CC[C@H]1CCOC2(CCOCC2)C1)c1ccccc1.,[NH3+][C@H](CC[C@H]1CCOC2(CCOCC2)C1)c1ccccc1,benzene_ring
+147952,Please remove a nitrile from the molecule Cc1cc(SCC(=O)NC2(C#N)CCCCC2)nc2ccccc12.,Cc1cc(SCC(=O)NC2(C#N)CCCCC2)nc2ccccc12,nitrile
+15006,Please remove a benzene_ring from the molecule CC(C)Cc1nnc([C@@H](C)[NH+]2CCC(c3ccc(F)cc3)CC2)o1.,CC(C)Cc1nnc([C@@H](C)[NH+]2CCC(c3ccc(F)cc3)CC2)o1,benzene_ring
+198802,Please remove a amide from the molecule COC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CSC(C)(C)N1C=O.,COC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CSC(C)(C)N1C=O,amide
+148945,Modify the molecule Cc1sc2nc(C[NH+]3CCN(CC(=O)NCCC4=CCCCC4)CC3)[nH]c(=O)c2c1C by removing a amide.,Cc1sc2nc(C[NH+]3CCN(CC(=O)NCCC4=CCCCC4)CC3)[nH]c(=O)c2c1C,amide
+50029,Remove a hydroxyl from the molecule C[NH+]1CCC(O)([C@@H]2CCOC3(CCC3)C2)CC1.,C[NH+]1CCC(O)([C@@H]2CCOC3(CCC3)C2)CC1,hydroxyl
+40734,Modify the molecule Fc1cc(Br)ccc1NCc1cccnc1Cl by removing a halo.,Fc1cc(Br)ccc1NCc1cccnc1Cl,halo
+143151,Modify the molecule CCN(C(=O)Cc1cc(C)[nH]n1)[C@@H]1CC[NH+]([C@@H](C)c2ccccc2)C1 by removing a amide.,CCN(C(=O)Cc1cc(C)[nH]n1)[C@@H]1CC[NH+]([C@@H](C)c2ccccc2)C1,amide
+143022,Please remove a amine from the molecule N#C[C@H]1CNCCN1C(=O)c1cccc(O)c1.,N#C[C@H]1CNCCN1C(=O)c1cccc(O)c1,amine
+176997,Remove a amide from the molecule C[C@H]1CC(C(=O)NCc2ccc(CN3CCc4ccccc43)cc2)C[C@H](C)O1.,C[C@H]1CC(C(=O)NCc2ccc(CN3CCc4ccccc43)cc2)C[C@H](C)O1,amide
+212068,Modify the molecule CCc1nnc(-c2ccc(NC(=O)C(=O)N[C@@H]3CCCC[C@@H]3C)cc2)o1 by removing a benzene_ring.,CCc1nnc(-c2ccc(NC(=O)C(=O)N[C@@H]3CCCC[C@@H]3C)cc2)o1,benzene_ring
+133191,Remove a benzene_ring from the molecule CCc1nnc(NC(=O)N[C@@H](C)c2ccc(F)c(F)c2)s1.,CCc1nnc(NC(=O)N[C@@H](C)c2ccc(F)c(F)c2)s1,benzene_ring
+138534,Remove a halo from the molecule CCCCNC(=O)N[C@H]1CCCN(c2ccc(OC(F)F)cc2)C1=O.,CCCCNC(=O)N[C@H]1CCCN(c2ccc(OC(F)F)cc2)C1=O,halo
+167272,Please remove a amine from the molecule Cc1nsc(Nc2ccc(F)c(F)c2)c1C#N.,Cc1nsc(Nc2ccc(F)c(F)c2)c1C#N,amine
+131552,Modify the molecule CC(=O)N(C)c1ccccn1 by removing a amide.,CC(=O)N(C)c1ccccn1,amide
+219404,Remove a benzene_ring from the molecule C[C@@H](c1ccccn1)N(C)C(=O)Nc1cccc(C2SCCS2)c1.,C[C@@H](c1ccccn1)N(C)C(=O)Nc1cccc(C2SCCS2)c1,benzene_ring
+616,Please remove a hydroxyl from the molecule CCOc1cc(CO)cc(Br)c1OCc1ccccc1F.,CCOc1cc(CO)cc(Br)c1OCc1ccccc1F,hydroxyl
+167861,Remove a amide from the molecule Cc1ccsc1/C=N/NC(=O)/C(=C\c1ccc2c(c1)OCO2)NC(=O)c1ccccc1.,Cc1ccsc1/C=N/NC(=O)/C(=C\c1ccc2c(c1)OCO2)NC(=O)c1ccccc1,amide
+216704,Remove a halo from the molecule CSc1cccc(NC(=O)N2CCN(c3ccccc3Cl)CC2)c1.,CSc1cccc(NC(=O)N2CCN(c3ccccc3Cl)CC2)c1,halo
+2366,Please remove a halo from the molecule Cc1ccc(O)c(NS(=O)(=O)c2cc(F)c(F)c(F)c2)c1.,Cc1ccc(O)c(NS(=O)(=O)c2cc(F)c(F)c(F)c2)c1,halo
+56176,Remove a amide from the molecule CCOC(=O)c1nn(-c2ccccc2C)c(=O)cc1NC(=O)c1ccc(Cl)cc1.,CCOC(=O)c1nn(-c2ccccc2C)c(=O)cc1NC(=O)c1ccc(Cl)cc1,amide
+38353,Modify the molecule O[C@@H](CN1CCc2sccc2C1)c1ccccc1 by removing a hydroxyl.,O[C@@H](CN1CCc2sccc2C1)c1ccccc1,hydroxyl
+53681,Remove a amide from the molecule O=C(Cn1c(=O)sc2cc(S(=O)(=O)N3CCCC3)ccc21)NC1CCCCC1.,O=C(Cn1c(=O)sc2cc(S(=O)(=O)N3CCCC3)ccc21)NC1CCCCC1,amide
+220132,Modify the molecule CC(=O)Nc1cc(NC(C)=O)cc(C(=O)Nc2ccc(/C=C\C(=O)c3ccccc3)cc2)c1 by removing a amide.,CC(=O)Nc1cc(NC(C)=O)cc(C(=O)Nc2ccc(/C=C\C(=O)c3ccccc3)cc2)c1,amide
+103486,Please remove a amide from the molecule COc1ccc(C(=O)N[C@@H](C(=O)Nc2ncc(C)s2)C(C)C)cc1.,COc1ccc(C(=O)N[C@@H](C(=O)Nc2ncc(C)s2)C(C)C)cc1,amide
+123881,Remove a benzene_ring from the molecule CN(c1ccccn1)S(=O)(=O)c1ccc(F)cc1F.,CN(c1ccccn1)S(=O)(=O)c1ccc(F)cc1F,benzene_ring
+205585,Please remove a amine from the molecule C/[NH+]=C(/NCc1noc(C)n1)N1CCc2cc(OC)c(OC)cc2C1.,C/[NH+]=C(/NCc1noc(C)n1)N1CCc2cc(OC)c(OC)cc2C1,amine
+220130,Please remove a amide from the molecule COc1ccc(CC[NH+](C)[C@H]2CCCN(C(=O)c3ccncc3)C2)cc1OC.,COc1ccc(CC[NH+](C)[C@H]2CCCN(C(=O)c3ccncc3)C2)cc1OC,amide
+129196,Remove a amide from the molecule CNC(=O)c1ccccc1NC(=O)[C@H]1CC[NH2+][C@H]1C.,CNC(=O)c1ccccc1NC(=O)[C@H]1CC[NH2+][C@H]1C,amide
+107596,Remove a amide from the molecule O=C(NCc1coc(-c2ccccc2)n1)c1cnc([C@H]2CCCO2)s1.,O=C(NCc1coc(-c2ccccc2)n1)c1cnc([C@H]2CCCO2)s1,amide
+216061,Modify the molecule CC[S@@](=O)[C@@H]1CCCC[C@@H]1NC(=O)Nc1ccccc1N1CCCCC1 by removing a benzene_ring.,CC[S@@](=O)[C@@H]1CCCC[C@@H]1NC(=O)Nc1ccccc1N1CCCCC1,benzene_ring
+149190,Remove a nitro from the molecule Cc1cccc(Nc2ncnc(N3CCCC[C@H]3C)c2[N+](=O)[O-])c1.,Cc1cccc(Nc2ncnc(N3CCCC[C@H]3C)c2[N+](=O)[O-])c1,nitro
+240059,Modify the molecule N#C[C@@H]1OC(=O)c2cccc(F)c21 by removing a halo.,N#C[C@@H]1OC(=O)c2cccc(F)c21,halo
+71673,Please remove a benzene_ring from the molecule COCC[C@@H]([NH3+])c1ncc(-c2cc(F)cc(F)c2)[nH]1.,COCC[C@@H]([NH3+])c1ncc(-c2cc(F)cc(F)c2)[nH]1,benzene_ring
+11067,Please remove a amide from the molecule Cc1cc(C)cc(NC(=O)C(=O)NCc2ncc(C)s2)c1.,Cc1cc(C)cc(NC(=O)C(=O)NCc2ncc(C)s2)c1,amide
+83046,Please remove a benzene_ring from the molecule CC[C@@H](NC(=O)NCc1scnc1C)C(C)(C)c1ccccc1.,CC[C@@H](NC(=O)NCc1scnc1C)C(C)(C)c1ccccc1,benzene_ring
+219496,Please remove a amine from the molecule O=c1c(N[C@H]2CCC[NH2+]C2)nccn1-c1ccccc1.,O=c1c(N[C@H]2CCC[NH2+]C2)nccn1-c1ccccc1,amine
+189280,Modify the molecule COc1ccccc1C[NH2+]CC[C@H]1CCCO1 by removing a benzene_ring.,COc1ccccc1C[NH2+]CC[C@H]1CCCO1,benzene_ring
+234047,Please remove a amide from the molecule C[C@H]1CC[C@@H](C)C[NH+]1CC(=O)NC1CCCC1.,C[C@H]1CC[C@@H](C)C[NH+]1CC(=O)NC1CCCC1,amide
+117396,Modify the molecule C[C@H](Nc1ccc(S(=O)(=O)N2CCN(C)CC2)cc1[N+](=O)[O-])c1ccc(F)cc1F by removing a halo.,C[C@H](Nc1ccc(S(=O)(=O)N2CCN(C)CC2)cc1[N+](=O)[O-])c1ccc(F)cc1F,halo
+16515,Remove a amide from the molecule O=C1c2ccccc2C(=O)N1C[C@H](c1ccco1)[NH+]1CCCCC1.,O=C1c2ccccc2C(=O)N1C[C@H](c1ccco1)[NH+]1CCCCC1,amide
+245161,Remove a hydroxyl from the molecule CC(C)n1c[nH+]cc1[C@H](O)[C@@H]1CCCCC[NH2+]1.,CC(C)n1c[nH+]cc1[C@H](O)[C@@H]1CCCCC[NH2+]1,hydroxyl
+38155,Modify the molecule CC(C)CC(=O)N[C@@H](CC(=O)[O-])c1ccccc1Cl by removing a benzene_ring.,CC(C)CC(=O)N[C@@H](CC(=O)[O-])c1ccccc1Cl,benzene_ring
+127320,Modify the molecule O=C(CSc1ncccc1Cl)N1CCC[C@H]1c1ccc2c(c1)OCCO2 by removing a halo.,O=C(CSc1ncccc1Cl)N1CCC[C@H]1c1ccc2c(c1)OCCO2,halo
+160486,Remove a amine from the molecule CN(C)c1ccc([C@H]2Nc3ccc(S(=O)(=O)NCc4ccccc4)cc3[C@@H]3C=CC[C@@H]23)cc1.,CN(C)c1ccc([C@H]2Nc3ccc(S(=O)(=O)NCc4ccccc4)cc3[C@@H]3C=CC[C@@H]23)cc1,amine
+27595,Remove a benzene_ring from the molecule CN1CCc2nc[nH]c2C12CC[NH+](Cc1cccc(OC3CCCC3)c1)CC2.,CN1CCc2nc[nH]c2C12CC[NH+](Cc1cccc(OC3CCCC3)c1)CC2,benzene_ring
+210211,Please remove a benzene_ring from the molecule Cc1nn(C)c(C)c1CCC[NH2+][C@@H](C)c1ccccc1.,Cc1nn(C)c(C)c1CCC[NH2+][C@@H](C)c1ccccc1,benzene_ring
+20033,Please remove a benzene_ring from the molecule CCCOc1ccc(OCCC2CC[NH2+]CC2)cc1.,CCCOc1ccc(OCCC2CC[NH2+]CC2)cc1,benzene_ring
+164892,Modify the molecule S=C(NN=C1CCSCC1)NC1CCCCC1 by removing a amine.,S=C(NN=C1CCSCC1)NC1CCCCC1,amine
+248653,Remove a benzene_ring from the molecule C[C@@H](Cc1ccc(Cl)cc1)N(C)C(=O)c1ccc2ncccc2c1.,C[C@@H](Cc1ccc(Cl)cc1)N(C)C(=O)c1ccc2ncccc2c1,benzene_ring
+8369,Modify the molecule Cc1ccc(F)c(C(=O)NNC(=S)NC[C@@H]2CCCO2)c1 by removing a benzene_ring.,Cc1ccc(F)c(C(=O)NNC(=S)NC[C@@H]2CCCO2)c1,benzene_ring
+49912,Remove a benzene_ring from the molecule O=C(NN=C1CCCc2ccccc21)C(O)(c1ccccc1)c1ccccc1.,O=C(NN=C1CCCc2ccccc21)C(O)(c1ccccc1)c1ccccc1,benzene_ring
+99506,Please remove a amide from the molecule Cc1nn(-c2ccc(Cl)cc2)cc1C(=O)N(C)CCN1CCOCC1.,Cc1nn(-c2ccc(Cl)cc2)cc1C(=O)N(C)CCN1CCOCC1,amide
+35724,Modify the molecule CC(C)CNC(=O)NC(=O)CSc1nc2ccccc2c(=O)n1C1CC1 by removing a amide.,CC(C)CNC(=O)NC(=O)CSc1nc2ccccc2c(=O)n1C1CC1,amide
+134342,Modify the molecule CCOC(=O)c1nn(CC)c2c1CN(C(=O)C1=CC3=CC=N[C@@H]3C=C1)CC2 by removing a amide.,CCOC(=O)c1nn(CC)c2c1CN(C(=O)C1=CC3=CC=N[C@@H]3C=C1)CC2,amide
+167887,Modify the molecule Cc1c(Cl)c(-c2ccc(N(C)S(C)(=O)=O)cc2)nc2cc3c(cc12)OCO3 by removing a halo.,Cc1c(Cl)c(-c2ccc(N(C)S(C)(=O)=O)cc2)nc2cc3c(cc12)OCO3,halo
+181887,Please remove a benzene_ring from the molecule COc1cccc(-c2cc3c(N4CCc5ccccc5C4)nccn3n2)c1.,COc1cccc(-c2cc3c(N4CCc5ccccc5C4)nccn3n2)c1,benzene_ring
+142223,Remove a benzene_ring from the molecule CN(Cc1ccccc1C(F)(F)F)C(=O)NCCOc1ccccc1.,CN(Cc1ccccc1C(F)(F)F)C(=O)NCCOc1ccccc1,benzene_ring
+177111,Remove a amide from the molecule Cc1ccnc(NNC(=O)c2ccc(S(=O)(=O)N(C)C)cc2)c1.,Cc1ccnc(NNC(=O)c2ccc(S(=O)(=O)N(C)C)cc2)c1,amide
+241225,Please remove a benzene_ring from the molecule N#C[C@H]1COCCN1Cc1cccc(-c2ccccn2)c1.,N#C[C@H]1COCCN1Cc1cccc(-c2ccccn2)c1,benzene_ring
+90270,Please remove a amide from the molecule Cc1ccncc1[N-]S(=O)(=O)c1c[nH]c(C(=O)N2CCCC2)c1.,Cc1ccncc1[N-]S(=O)(=O)c1c[nH]c(C(=O)N2CCCC2)c1,amide
+116102,Modify the molecule COC(=O)[C@H](N[C@H](C)c1cccc(-n2cccn2)c1)c1ccccc1F by removing a halo.,COC(=O)[C@H](N[C@H](C)c1cccc(-n2cccn2)c1)c1ccccc1F,halo
+204012,Remove a halo from the molecule C[C@H](NC(=O)Cc1cccc(F)c1F)C1(N2CCOCC2)CCCC1.,C[C@H](NC(=O)Cc1cccc(F)c1F)C1(N2CCOCC2)CCCC1,halo
+79641,Modify the molecule CC[NH+](C)CC[C@@H](c1ccccc1)[NH+]1CCOCC1 by removing a benzene_ring.,CC[NH+](C)CC[C@@H](c1ccccc1)[NH+]1CCOCC1,benzene_ring
+168748,Please remove a halo from the molecule CC(C)(C)CC(=O)Nc1ccc(F)cc1F.,CC(C)(C)CC(=O)Nc1ccc(F)cc1F,halo
+109135,Modify the molecule CCOC(=O)c1c(/C=C/C(=O)N(C)C2(C#N)CCC2)c(C)n(CC)c1C by removing a amide.,CCOC(=O)c1c(/C=C/C(=O)N(C)C2(C#N)CCC2)c(C)n(CC)c1C,amide
+98640,Modify the molecule COc1ccc(OC)c2nc(Cl)c(CCN3C(=O)c4ccccc4C3=O)cc12 by removing a halo.,COc1ccc(OC)c2nc(Cl)c(CCN3C(=O)c4ccccc4C3=O)cc12,halo
+15982,Remove a amide from the molecule CCn1c(COc2cccc3cccnc23)nnc1SCC(N)=O.,CCn1c(COc2cccc3cccnc23)nnc1SCC(N)=O,amide
+238090,Modify the molecule C[C@@H](Cc1ccc(Cl)cc1Cl)C(=O)N(C)C1CCOCC1 by removing a benzene_ring.,C[C@@H](Cc1ccc(Cl)cc1Cl)C(=O)N(C)C1CCOCC1,benzene_ring
+117212,Remove a amide from the molecule COCc1ccc(C(=O)N[C@H]2C[C@@](C)(OC)C2(C)C)o1.,COCc1ccc(C(=O)N[C@H]2C[C@@](C)(OC)C2(C)C)o1,amide
+131407,Please remove a amide from the molecule CC[C@H]1CN(C(C)=O)CC[C@H]1CC(=O)Nc1nccs1.,CC[C@H]1CN(C(C)=O)CC[C@H]1CC(=O)Nc1nccs1,amide
+69875,Modify the molecule CCN(CC)S(=O)(=O)c1ccc(NC(=O)C2CCCC2)cc1 by removing a amide.,CCN(CC)S(=O)(=O)c1ccc(NC(=O)C2CCCC2)cc1,amide
+72927,Modify the molecule C[C@@H]([NH2+]CC1(CO)CCOCC1)c1cc(F)c(F)c(F)c1 by removing a halo.,C[C@@H]([NH2+]CC1(CO)CCOCC1)c1cc(F)c(F)c(F)c1,halo
+204499,Modify the molecule O=C([C@H]1SCCc2sccc21)N1CCO[C@H](c2ccc(F)cc2)C1 by removing a halo.,O=C([C@H]1SCCc2sccc21)N1CCO[C@H](c2ccc(F)cc2)C1,halo
+56665,Modify the molecule CC[C@H](C)[C@@H](C(=O)Nc1ccn(C)n1)N1C(=O)c2ccccc2C1=O by removing a amide.,CC[C@H](C)[C@@H](C(=O)Nc1ccn(C)n1)N1C(=O)c2ccccc2C1=O,amide
+13930,Please remove a amine from the molecule CCNc1cc[nH+]c(CN2CCO[C@H]3CCCC[C@@H]32)c1.,CCNc1cc[nH+]c(CN2CCO[C@H]3CCCC[C@@H]32)c1,amine
+53558,Modify the molecule COc1ccccc1NC(=O)CSc1nnc(-c2ccccn2)o1 by removing a amide.,COc1ccccc1NC(=O)CSc1nnc(-c2ccccn2)o1,amide
+242568,Please remove a benzene_ring from the molecule Cc1noc(C)c1CCCNC(=O)Nc1cccc(C(C)C)c1.,Cc1noc(C)c1CCCNC(=O)Nc1cccc(C(C)C)c1,benzene_ring
+10298,Remove a amide from the molecule CN(C(=O)CSc1nnc(-c2ccccc2F)o1)c1ccccc1.,CN(C(=O)CSc1nnc(-c2ccccc2F)o1)c1ccccc1,amide
+59131,Remove a hydroxyl from the molecule Cc1nnc(SC[C@@H](O)CN2CCOCC2)s1.,Cc1nnc(SC[C@@H](O)CN2CCOCC2)s1,hydroxyl
+243091,Remove a halo from the molecule CC(C)Cn1ncc(C(=O)N(C)[C@@H](C)Cc2ccsc2)c1C(F)F.,CC(C)Cn1ncc(C(=O)N(C)[C@@H](C)Cc2ccsc2)c1C(F)F,halo
+194198,Please remove a amine from the molecule CC(=O)c1c(C)nsc1N[C@H](C)c1ccc(C)cc1.,CC(=O)c1c(C)nsc1N[C@H](C)c1ccc(C)cc1,amine
+18798,Modify the molecule CCc1ccc(NC(=O)C(=O)NCC2(C)CCCC2)cc1[N+](=O)[O-] by removing a nitro.,CCc1ccc(NC(=O)C(=O)NCC2(C)CCCC2)cc1[N+](=O)[O-],nitro
+135449,Please remove a amine from the molecule C/[NH+]=C(/NCCc1c[nH]c2cc(C)ccc12)NCc1cn2c(C)cccc2[nH+]1.,C/[NH+]=C(/NCCc1c[nH]c2cc(C)ccc12)NCc1cn2c(C)cccc2[nH+]1,amine
+165793,Remove a halo from the molecule COC(=O)c1ccc2c(c1C)N[C@H](c1cc(Br)c(OC)c(OC)c1)[C@H]1CC=C[C@H]21.,COC(=O)c1ccc2c(c1C)N[C@H](c1cc(Br)c(OC)c(OC)c1)[C@H]1CC=C[C@H]21,halo
+87066,Remove a amide from the molecule COCCN(Cc1ccco1)C(=O)c1cc2cc([N+](=O)[O-])ccc2s1.,COCCN(Cc1ccco1)C(=O)c1cc2cc([N+](=O)[O-])ccc2s1,amide
+116858,Modify the molecule CCOc1ccc2[nH]c(=O)c(CNc3ccc(N4CCc5ccccc5C4)cc3)cc2c1 by removing a amine.,CCOc1ccc2[nH]c(=O)c(CNc3ccc(N4CCc5ccccc5C4)cc3)cc2c1,amine
+198065,Remove a benzene_ring from the molecule CN(Cc1nnc2n1CCC2)C(=O)c1ccc(S(C)(=O)=O)cc1.,CN(Cc1nnc2n1CCC2)C(=O)c1ccc(S(C)(=O)=O)cc1,benzene_ring
+147864,Please remove a halo from the molecule COc1cc(-c2noc(CN3C[C@H](C)c4ccccc43)n2)ccc1OC(F)F.,COc1cc(-c2noc(CN3C[C@H](C)c4ccccc43)n2)ccc1OC(F)F,halo
+33899,Remove a amide from the molecule CCC(CC)N(CC(C)C)C(=O)[C@H]1CC[C@@H]([NH3+])C1.,CCC(CC)N(CC(C)C)C(=O)[C@H]1CC[C@@H]([NH3+])C1,amide
+28564,Remove a amide from the molecule CN(CC(=O)N1N=C(c2ccc(Cl)cc2)C[C@@H]1c1ccco1)S(=O)(=O)c1cccs1.,CN(CC(=O)N1N=C(c2ccc(Cl)cc2)C[C@@H]1c1ccco1)S(=O)(=O)c1cccs1,amide
+89014,Remove a amine from the molecule CN(C(=O)c1cccc(NCC(=O)NCc2ccco2)c1)c1ccccc1.,CN(C(=O)c1cccc(NCC(=O)NCc2ccco2)c1)c1ccccc1,amine
+7136,Remove a hydroxyl from the molecule Cc1ccc(CC(=O)NNc2c(Cl)cccc2Cl)cc1O.,Cc1ccc(CC(=O)NNc2c(Cl)cccc2Cl)cc1O,hydroxyl
+223264,Remove a thiol from the molecule SCC1(COC2CCCC2)CC1.,SCC1(COC2CCCC2)CC1,thiol
+232768,Please remove a halo from the molecule COC(=O)c1cc(NC(=O)C2CCN(C(=O)c3ccccc3Cl)CC2)cc(C(=O)OC)c1.,COC(=O)c1cc(NC(=O)C2CCN(C(=O)c3ccccc3Cl)CC2)cc(C(=O)OC)c1,halo
+234248,Modify the molecule C[NH+]1CCC[C@H](C(=O)NCc2ccc[nH]2)C1 by removing a amide.,C[NH+]1CCC[C@H](C(=O)NCc2ccc[nH]2)C1,amide
+62252,Remove a benzene_ring from the molecule Cc1ccc([C@@H](C)N(C)C(=O)c2nnn[n-]2)cc1.,Cc1ccc([C@@H](C)N(C)C(=O)c2nnn[n-]2)cc1,benzene_ring
+61692,Remove a amide from the molecule Cc1ccc(C)c(NC(=O)c2ncccc2OCC(F)(F)F)c1.,Cc1ccc(C)c(NC(=O)c2ncccc2OCC(F)(F)F)c1,amide
+247910,Please remove a benzene_ring from the molecule COc1ccc([C@H]2CC(=O)C=C(N)C2)cc1.,COc1ccc([C@H]2CC(=O)C=C(N)C2)cc1,benzene_ring
+62350,Modify the molecule COCCn1c(C)cc(/C=C(/C#N)C(=O)N[C@H]2CCCNC2=O)c1C by removing a nitrile.,COCCn1c(C)cc(/C=C(/C#N)C(=O)N[C@H]2CCCNC2=O)c1C,nitrile
+99070,Modify the molecule C[C@H](Oc1ccc(Cl)cc1Cl)C(=O)NNC(=O)[C@H]1CCCC[C@H]1C(=O)[O-] by removing a halo.,C[C@H](Oc1ccc(Cl)cc1Cl)C(=O)NNC(=O)[C@H]1CCCC[C@H]1C(=O)[O-],halo
+244156,Please remove a benzene_ring from the molecule Cc1cc(C2=N/C(=C\c3cc4c(cc3Cl)OCO4)C(=O)O2)ccc1Br.,Cc1cc(C2=N/C(=C\c3cc4c(cc3Cl)OCO4)C(=O)O2)ccc1Br,benzene_ring
+60282,Remove a amide from the molecule O=C(Nc1nccs1)[C@H]1c2ccccc2C(=O)N(C2CCCC2)C12CCCC2.,O=C(Nc1nccs1)[C@H]1c2ccccc2C(=O)N(C2CCCC2)C12CCCC2,amide
+156840,Remove a amide from the molecule O=C(NC[C@H](c1cccs1)[NH+]1CCCC1)[C@@H]1CCCN1C(=O)c1ccc(Br)cc1.,O=C(NC[C@H](c1cccs1)[NH+]1CCCC1)[C@@H]1CCCN1C(=O)c1ccc(Br)cc1,amide
+99808,Please remove a amide from the molecule CCNC(=O)c1ccc([NH+]2C[C@@H](C)[C@H](C(=O)[O-])C2)[nH+]n1.,CCNC(=O)c1ccc([NH+]2C[C@@H](C)[C@H](C(=O)[O-])C2)[nH+]n1,amide
+76461,Modify the molecule C[NH+]1C[C@@H](c2ccc([N+](=O)[O-])cc2)[C@@H](C(=O)c2ccc(F)cc2)[C@@]12C(=O)Nc1ccccc12 by removing a nitro.,C[NH+]1C[C@@H](c2ccc([N+](=O)[O-])cc2)[C@@H](C(=O)c2ccc(F)cc2)[C@@]12C(=O)Nc1ccccc12,nitro
+88769,Remove a amide from the molecule O=C([O-])c1ccc(N2C(=O)/C(=C/C3=c4ccccc4=[NH+]C3)SC2=S)cc1O.,O=C([O-])c1ccc(N2C(=O)/C(=C/C3=c4ccccc4=[NH+]C3)SC2=S)cc1O,amide
+56395,Please remove a halo from the molecule O=C(CSc1nnc(-c2cccs2)n1C1CC1)Nc1cc2[nH]c(=O)[nH]c2cc1Br.,O=C(CSc1nnc(-c2cccs2)n1C1CC1)Nc1cc2[nH]c(=O)[nH]c2cc1Br,halo
+197167,Please remove a amide from the molecule O=C(NCC1CCCCC1)c1cccc(NC(=O)c2scc3c2OCO3)c1.,O=C(NCC1CCCCC1)c1cccc(NC(=O)c2scc3c2OCO3)c1,amide
+71068,Please remove a hydroxyl from the molecule O=C(CCCNC(=O)c1cccs1)NC[C@@]1(O)CCSC1.,O=C(CCCNC(=O)c1cccs1)NC[C@@]1(O)CCSC1,hydroxyl
+98251,Remove a halo from the molecule COc1c(Cl)cc(C(=O)OCc2nc(C)no2)cc1Cl.,COc1c(Cl)cc(C(=O)OCc2nc(C)no2)cc1Cl,halo
+134822,Please remove a amide from the molecule COc1cc(CC(=O)Nc2ccc(C)cc2OC)ccc1C.,COc1cc(CC(=O)Nc2ccc(C)cc2OC)ccc1C,amide
+166474,Please remove a nitrile from the molecule N#CCCCSc1nnc(-c2ccccc2)n1-c1ccccc1.,N#CCCCSc1nnc(-c2ccccc2)n1-c1ccccc1,nitrile
+45146,Remove a hydroxyl from the molecule COc1cccc([C@H](C)CC(=O)Nc2cnc(-c3cccc(O)c3)nc2)c1.,COc1cccc([C@H](C)CC(=O)Nc2cnc(-c3cccc(O)c3)nc2)c1,hydroxyl
+123259,Modify the molecule O=C(CNC(=O)C(=O)Nc1ccccc1C[NH+]1CCCC1)NC1CC1 by removing a benzene_ring.,O=C(CNC(=O)C(=O)Nc1ccccc1C[NH+]1CCCC1)NC1CC1,benzene_ring
+206350,Remove a hydroxyl from the molecule Cc1nn(Cc2ccccc2)c(C)c1CNC(=O)N[C@H]1CCCC[C@@H]1CO.,Cc1nn(Cc2ccccc2)c(C)c1CNC(=O)N[C@H]1CCCC[C@@H]1CO,hydroxyl
+163345,Remove a amide from the molecule CC(=O)NCCc1nc2ccccc2n1CC(=O)NC[C@H]1CCCO1.,CC(=O)NCCc1nc2ccccc2n1CC(=O)NC[C@H]1CCCO1,amide
+238412,Remove a nitrile from the molecule Cc1nc([O-])c(C#N)cc1C(=O)N1CCC[C@@H](c2[nH+]ccn2CC(N)=O)C1.,Cc1nc([O-])c(C#N)cc1C(=O)N1CCC[C@@H](c2[nH+]ccn2CC(N)=O)C1,nitrile
+110180,Please remove a amide from the molecule CNC(=O)CC1CCN(C(=O)N[C@@H]2C[C@H]2c2ccccc2F)CC1.,CNC(=O)CC1CCN(C(=O)N[C@@H]2C[C@H]2c2ccccc2F)CC1,amide
+200810,Please remove a halo from the molecule CCCNC(=O)CNC(=O)N[C@H](CC)c1ccc(C)c(F)c1.,CCCNC(=O)CNC(=O)N[C@H](CC)c1ccc(C)c(F)c1,halo
+191953,Please remove a halo from the molecule Nc1ccc(S[C@H]2CCC[C@@H]2O)cc1Cl.,Nc1ccc(S[C@H]2CCC[C@@H]2O)cc1Cl,halo
+121105,Remove a amide from the molecule CC(C)OCCC(=O)Nc1cccc(C(=O)NC(C)(C)C)c1.,CC(C)OCCC(=O)Nc1cccc(C(=O)NC(C)(C)C)c1,amide
+52959,Remove a amide from the molecule CCc1c(C)nc(-n2nc(-c3ccco3)cc2NC(=O)COc2cccc3c2OC(C)(C)C3)nc1[O-].,CCc1c(C)nc(-n2nc(-c3ccco3)cc2NC(=O)COc2cccc3c2OC(C)(C)C3)nc1[O-],amide
+62912,Remove a benzene_ring from the molecule Cc1c(NCC2(c3ccc(F)cc3)CCOCC2)cc(C#N)cc1[N+](=O)[O-].,Cc1c(NCC2(c3ccc(F)cc3)CCOCC2)cc(C#N)cc1[N+](=O)[O-],benzene_ring
+90971,Remove a amide from the molecule CC1CCN(S(=O)(=O)c2ccc(-c3noc(CCC(=O)Nc4cccc(F)c4)n3)cc2)CC1.,CC1CCN(S(=O)(=O)c2ccc(-c3noc(CCC(=O)Nc4cccc(F)c4)n3)cc2)CC1,amide
+46982,Remove a amide from the molecule O=C(c1ccc(-c2ccc(F)cc2)o1)N(Cc1ccccn1)C1CC1.,O=C(c1ccc(-c2ccc(F)cc2)o1)N(Cc1ccccn1)C1CC1,amide
+127222,Please remove a hydroxyl from the molecule CCOCCN(C)C(=O)NCc1ccc(O)c(Br)c1.,CCOCCN(C)C(=O)NCc1ccc(O)c(Br)c1,hydroxyl
+210894,Please remove a amide from the molecule O=C(NC(=S)NNC(=O)c1cccs1)c1cc2ccccc2o1.,O=C(NC(=S)NNC(=O)c1cccs1)c1cc2ccccc2o1,amide
+161773,Modify the molecule O=C(NC[C@@H](Cc1ccccc1)NC(=O)c1cnccn1)c1cnccn1 by removing a benzene_ring.,O=C(NC[C@@H](Cc1ccccc1)NC(=O)c1cnccn1)c1cnccn1,benzene_ring
+174105,Please remove a amide from the molecule O=C(Cc1ccccc1Cl)NCc1ccnc(-n2cccn2)c1.,O=C(Cc1ccccc1Cl)NCc1ccnc(-n2cccn2)c1,amide
+157825,Please remove a benzene_ring from the molecule COCCc1ccc(OS(=O)(=O)c2ccc3c(c2)CCCC3)cc1.,COCCc1ccc(OS(=O)(=O)c2ccc3c(c2)CCCC3)cc1,benzene_ring
+242281,Modify the molecule CC(C)(CNc1ccc(C#N)c([N+](=O)[O-])c1)S(C)(=O)=O by removing a amine.,CC(C)(CNc1ccc(C#N)c([N+](=O)[O-])c1)S(C)(=O)=O,amine
+125896,Modify the molecule Cc1cc(N[C@@H](C(N)=O)c2ccccc2)ccc1C(=O)NC(C)C by removing a amide.,Cc1cc(N[C@@H](C(N)=O)c2ccccc2)ccc1C(=O)NC(C)C,amide
+182665,Remove a halo from the molecule COc1ccc(CN2CC[C@H]3[C@H](CCC[NH+]3C3CC3)C2)cc1OC(F)F.,COc1ccc(CN2CC[C@H]3[C@H](CCC[NH+]3C3CC3)C2)cc1OC(F)F,halo
+112270,Modify the molecule CC[NH+](CC)c1ccc([N-]S(=O)(=O)c2ccc(Cl)s2)cc1C(=O)[O-] by removing a benzene_ring.,CC[NH+](CC)c1ccc([N-]S(=O)(=O)c2ccc(Cl)s2)cc1C(=O)[O-],benzene_ring
+129583,Modify the molecule C[C@H]1CCC[C@@H](NC(=O)c2ccc3c([O-])n(C)c(=S)nc3c2)[C@@H]1C by removing a amide.,C[C@H]1CCC[C@@H](NC(=O)c2ccc3c([O-])n(C)c(=S)nc3c2)[C@@H]1C,amide
+167244,Modify the molecule CC(C)CN1C(=O)/C(=C2\C(=O)N(CC(=O)Nc3ccccc3Cl)c3ccccc32)SC1=S by removing a halo.,CC(C)CN1C(=O)/C(=C2\C(=O)N(CC(=O)Nc3ccccc3Cl)c3ccccc32)SC1=S,halo
+13293,Please remove a halo from the molecule O=C1O[C@H](/C=N/c2ccc(C(F)(F)F)cc2)c2ccccc21.,O=C1O[C@H](/C=N/c2ccc(C(F)(F)F)cc2)c2ccccc21,halo
+239955,Please remove a amine from the molecule CCOc1ccc([C@H]2C3=C(CCCC3=O)Nc3c(C(=O)Nc4ccc(F)cc4)cnn32)cc1.,CCOc1ccc([C@H]2C3=C(CCCC3=O)Nc3c(C(=O)Nc4ccc(F)cc4)cnn32)cc1,amine
+162141,Modify the molecule C[C@H](Cc1ccc(Cl)cc1)N(C)C(=O)c1c[nH]c2nccc(Cl)c12 by removing a amide.,C[C@H](Cc1ccc(Cl)cc1)N(C)C(=O)c1c[nH]c2nccc(Cl)c12,amide
+92841,Modify the molecule CC[C@@H](C(=O)NNC(=O)N[C@@H](c1ccccn1)C(C)C)c1ccccc1 by removing a benzene_ring.,CC[C@@H](C(=O)NNC(=O)N[C@@H](c1ccccn1)C(C)C)c1ccccc1,benzene_ring
+231809,Remove a amine from the molecule CCc1cc[n+](/C(C(=O)c2ccc3c(c2)OCO3)=C(/[S-])NC2CC2)cc1.,CCc1cc[n+](/C(C(=O)c2ccc3c(c2)OCO3)=C(/[S-])NC2CC2)cc1,amine
+128945,Remove a amide from the molecule O=C(c1cccc(Cl)c1)N(CCN1CCOCC1)c1nc2c(F)cc(F)cc2s1.,O=C(c1cccc(Cl)c1)N(CCN1CCOCC1)c1nc2c(F)cc(F)cc2s1,amide
+175713,Please remove a amide from the molecule COCCCNC(=O)N1CCC[NH+](CC(=O)N(C)C)CC1.,COCCCNC(=O)N1CCC[NH+](CC(=O)N(C)C)CC1,amide
+63829,Modify the molecule CC[C@H](C)[C@H](O)CNC(=O)C(=O)Nc1ccc(C)nc1Br by removing a amide.,CC[C@H](C)[C@H](O)CNC(=O)C(=O)Nc1ccc(C)nc1Br,amide
+104165,Please remove a amide from the molecule CCO[C@H](C)c1nc(C[NH+](C)CC(N)=O)cs1.,CCO[C@H](C)c1nc(C[NH+](C)CC(N)=O)cs1,amide
+102012,Please remove a amide from the molecule CCN1C(=O)Cc2ccccc2[C@H]1C(=O)NCCC1=CCCCC1.,CCN1C(=O)Cc2ccccc2[C@H]1C(=O)NCCC1=CCCCC1,amide
+142588,Remove a hydroxyl from the molecule O=C(NC[C@@H](O)c1ccoc1)[C@@H]1COc2ccccc2O1.,O=C(NC[C@@H](O)c1ccoc1)[C@@H]1COc2ccccc2O1,hydroxyl
+16353,Remove a nitrile from the molecule CC(C)NC(=O)/C(C#N)=C(/[O-])[C@H]1C[C@@H]1c1ccc(C(C)C)cc1.,CC(C)NC(=O)/C(C#N)=C(/[O-])[C@H]1C[C@@H]1c1ccc(C(C)C)cc1,nitrile
+111613,Please remove a amide from the molecule C[C@@H](Sc1nnc2ccc(C(F)(F)F)cn12)C(=O)N(C)C.,C[C@@H](Sc1nnc2ccc(C(F)(F)F)cn12)C(=O)N(C)C,amide
+56345,Please remove a amine from the molecule Cc1ccc(C)c(NC(=S)NC[C@@H](c2cccnc2)N2CCOCC2)c1.,Cc1ccc(C)c(NC(=S)NC[C@@H](c2cccnc2)N2CCOCC2)c1,amine
+18667,Remove a hydroxyl from the molecule C/C=C(/C)C(=O)O[C@H]1[C@@H](O[C@@]2(C)CC[C@@H](O)[C@@]3(C)CC=C(C(C)C)C[C@@H]23)O[C@H](C)[C@H](O)[C@H]1O.,C/C=C(/C)C(=O)O[C@H]1[C@@H](O[C@@]2(C)CC[C@@H](O)[C@@]3(C)CC=C(C(C)C)C[C@@H]23)O[C@H](C)[C@H](O)[C@H]1O,hydroxyl
+157191,Please remove a benzene_ring from the molecule COc1cc(C[NH+](C)CCn2cnnc2)cc(Cl)c1OC.,COc1cc(C[NH+](C)CCn2cnnc2)cc(Cl)c1OC,benzene_ring
+38920,Please remove a halo from the molecule C[C@@H](NC(=O)[C@H]1C[C@@H]1c1ccco1)c1noc(-c2ccc(Cl)cc2)n1.,C[C@@H](NC(=O)[C@H]1C[C@@H]1c1ccco1)c1noc(-c2ccc(Cl)cc2)n1,halo
+86943,Please remove a amide from the molecule CC(=O)N1CCCc2cc(NC(=O)[C@@H](C)Cc3c(C)n[nH]c3C)ccc21.,CC(=O)N1CCCc2cc(NC(=O)[C@@H](C)Cc3c(C)n[nH]c3C)ccc21,amide
+57634,Please remove a amide from the molecule CC1(C)Cc2c(cnn2-c2ccc(F)cc2)[C@@H](NC(=O)CCC(F)(F)F)C1.,CC1(C)Cc2c(cnn2-c2ccc(F)cc2)[C@@H](NC(=O)CCC(F)(F)F)C1,amide
+244511,Modify the molecule Cc1occc1COC(=O)c1cccnc1OCC(F)(F)F by removing a halo.,Cc1occc1COC(=O)c1cccnc1OCC(F)(F)F,halo
+26592,Please remove a benzene_ring from the molecule C[NH2+][C@@H](CSc1ccc(Cl)cc1)C1CC1.,C[NH2+][C@@H](CSc1ccc(Cl)cc1)C1CC1,benzene_ring
+63744,Please remove a amide from the molecule COc1ccc([C@H]2c3nc[nH]c3CCN2C(=O)c2c(C)nc3c(C)cccn23)cc1.,COc1ccc([C@H]2c3nc[nH]c3CCN2C(=O)c2c(C)nc3c(C)cccn23)cc1,amide
+178100,Remove a benzene_ring from the molecule C/C(=N\NC(=O)CSc1ccc(Cl)cc1)c1ccc(Br)cc1.,C/C(=N\NC(=O)CSc1ccc(Cl)cc1)c1ccc(Br)cc1,benzene_ring
+164909,Please remove a benzene_ring from the molecule Cc1cc(Br)cc([N+](=O)[O-])c1O[C@@H]1CC(=O)C12CCCC2.,Cc1cc(Br)cc([N+](=O)[O-])c1O[C@@H]1CC(=O)C12CCCC2,benzene_ring
+82365,Modify the molecule COCC1=C2[C@H](c3cc(OC)ccc3OC)C(C#N)=C(N)O[C@H]2N=N1 by removing a benzene_ring.,COCC1=C2[C@H](c3cc(OC)ccc3OC)C(C#N)=C(N)O[C@H]2N=N1,benzene_ring
+240634,Remove a benzene_ring from the molecule CC[C@@H](Oc1cc(Cl)ccc1Cl)C(=O)NNC(=O)[C@H]1[C@@H](C(=O)[O-])[C@H]2CC[C@@H]1C2.,CC[C@@H](Oc1cc(Cl)ccc1Cl)C(=O)NNC(=O)[C@H]1[C@@H](C(=O)[O-])[C@H]2CC[C@@H]1C2,benzene_ring
+20516,Please remove a amide from the molecule C=CCNC(=O)c1ccc(NC(=O)c2ccc3[nH]cnc3c2)cc1.,C=CCNC(=O)c1ccc(NC(=O)c2ccc3[nH]cnc3c2)cc1,amide
+222404,Modify the molecule CNC(=O)/C=C/c1ccc(OC(F)F)cc1OC(F)F by removing a benzene_ring.,CNC(=O)/C=C/c1ccc(OC(F)F)cc1OC(F)F,benzene_ring
+115485,Please remove a benzene_ring from the molecule CSc1ccc([C@H](O)c2cc(C)c(Cl)cc2C)cc1.,CSc1ccc([C@H](O)c2cc(C)c(Cl)cc2C)cc1,benzene_ring
+89866,Modify the molecule C[C@@H](c1ccccc1F)N(C)C(=O)CN(C)C(=O)c1ccccc1 by removing a halo.,C[C@@H](c1ccccc1F)N(C)C(=O)CN(C)C(=O)c1ccccc1,halo
+103517,Remove a benzene_ring from the molecule COc1cc(OC)c(C[NH+]2CC[C@H](C)[C@@H](n3ccnc3)C2)c(OC)c1.,COc1cc(OC)c(C[NH+]2CC[C@H](C)[C@@H](n3ccnc3)C2)c(OC)c1,benzene_ring
+163614,Modify the molecule COc1ccc([C@@H]2C[C@@H](c3ccc(Cl)c(Cl)c3)Nc3nc(N)nn32)cc1OC by removing a benzene_ring.,COc1ccc([C@@H]2C[C@@H](c3ccc(Cl)c(Cl)c3)Nc3nc(N)nn32)cc1OC,benzene_ring
+221454,Modify the molecule C[C@H](c1ccccc1-n1cccn1)n1ccnc1-c1ccco1 by removing a benzene_ring.,C[C@H](c1ccccc1-n1cccn1)n1ccnc1-c1ccco1,benzene_ring
+241131,Modify the molecule Cc1cnc2c(c1)N(C(=O)c1ccc(C(F)(F)F)nc1)CCO2 by removing a amide.,Cc1cnc2c(c1)N(C(=O)c1ccc(C(F)(F)F)nc1)CCO2,amide
+236975,Remove a benzene_ring from the molecule COc1ccc(-c2ccc(SCc3ccc(F)cc3)nn2)cc1.,COc1ccc(-c2ccc(SCc3ccc(F)cc3)nn2)cc1,benzene_ring
+9864,Remove a benzene_ring from the molecule CC(C)Sc1ccccc1C(=O)NCc1ccccn1.,CC(C)Sc1ccccc1C(=O)NCc1ccccn1,benzene_ring
+136211,Remove a halo from the molecule O=C(Cc1csc(-c2ccccc2Cl)n1)N[C@H]1CCCNC1=O.,O=C(Cc1csc(-c2ccccc2Cl)n1)N[C@H]1CCCNC1=O,halo
+148143,Modify the molecule CC1=NN(c2nc(-c3ccccc3)cs2)C(=O)/C1=N/Nc1cccc([N+](=O)[O-])c1C by removing a amine.,CC1=NN(c2nc(-c3ccccc3)cs2)C(=O)/C1=N/Nc1cccc([N+](=O)[O-])c1C,amine
+70115,Please remove a halo from the molecule CCc1ccc(Cl)c(CC)c1NC(=O)[C@H]1CS[C@@]2(C)CCC(=O)N12.,CCc1ccc(Cl)c(CC)c1NC(=O)[C@H]1CS[C@@]2(C)CCC(=O)N12,halo
+124757,Modify the molecule COc1ccc(-c2nc(NC3CC[NH2+]CC3)cc(-c3ccncc3)n2)cc1 by removing a benzene_ring.,COc1ccc(-c2nc(NC3CC[NH2+]CC3)cc(-c3ccncc3)n2)cc1,benzene_ring
+167678,Modify the molecule C/C(CCc1ccccc1)=N\NC(=O)c1ccc(CN2CCOCC2)cc1 by removing a amide.,C/C(CCc1ccccc1)=N\NC(=O)c1ccc(CN2CCOCC2)cc1,amide
+214822,Modify the molecule CCOc1ccc([C@@]2(O)CCCS[C@H]2C)cc1OCC by removing a benzene_ring.,CCOc1ccc([C@@]2(O)CCCS[C@H]2C)cc1OCC,benzene_ring
+40207,Please remove a amide from the molecule COCc1ccccc1C(=O)NC[C@H]1C[C@@]12CCc1ccccc12.,COCc1ccccc1C(=O)NC[C@H]1C[C@@]12CCc1ccccc12,amide
+50232,Modify the molecule CCc1nn(C)cc1CNC(=O)Nc1ccc(OC2CCOCC2)c(C)c1 by removing a benzene_ring.,CCc1nn(C)cc1CNC(=O)Nc1ccc(OC2CCOCC2)c(C)c1,benzene_ring
+98191,Please remove a amine from the molecule NC(=O)[C@@H](NCc1ccc(OC2CCCC2)nc1)c1ccccc1.,NC(=O)[C@@H](NCc1ccc(OC2CCCC2)nc1)c1ccccc1,amine
+121095,Please remove a halo from the molecule CCn1nccc1[C@@H](C)[NH2+]Cc1cc(C(F)(F)F)n[nH]1.,CCn1nccc1[C@@H](C)[NH2+]Cc1cc(C(F)(F)F)n[nH]1,halo
+73769,Remove a amide from the molecule Cc1ccc(NC(=O)CSc2nnc3c(Cl)cc(C(F)(F)F)cn23)c(Cl)c1.,Cc1ccc(NC(=O)CSc2nnc3c(Cl)cc(C(F)(F)F)cn23)c(Cl)c1,amide
+101778,Modify the molecule COCCn1c(C(=O)NCCN2CCN(C(C)=O)CC2)cc2ccccc21 by removing a amide.,COCCn1c(C(=O)NCCN2CCN(C(C)=O)CC2)cc2ccccc21,amide
+51446,Remove a halo from the molecule CCC(CC)(C[NH3+])NC(=O)Cc1ccc(F)c(F)c1.,CCC(CC)(C[NH3+])NC(=O)Cc1ccc(F)c(F)c1,halo
+218089,Modify the molecule O=C(Cn1nnc(-c2ccccc2Cl)n1)N/N=C/c1cc(Cl)ccc1O by removing a amide.,O=C(Cn1nnc(-c2ccccc2Cl)n1)N/N=C/c1cc(Cl)ccc1O,amide
+182858,Remove a amine from the molecule O=C(OCC(=O)N1CCc2ccccc21)c1ccccc1NS(=O)(=O)c1ccc2c(c1)OCCO2.,O=C(OCC(=O)N1CCc2ccccc21)c1ccccc1NS(=O)(=O)c1ccc2c(c1)OCCO2,amine
+174031,Please remove a halo from the molecule O=C(NCc1cccn1Cc1cccc(F)c1)Nc1ccccc1C(F)(F)F.,O=C(NCc1cccn1Cc1cccc(F)c1)Nc1ccccc1C(F)(F)F,halo
+168019,Remove a halo from the molecule C[C@@H]1CCCC[C@@H]1[NH2+]CCn1ccc2c(Cl)cccc21.,C[C@@H]1CCCC[C@@H]1[NH2+]CCn1ccc2c(Cl)cccc21,halo
+212025,Modify the molecule CC(C)(C)OC(=O)N1CCC(N)(C(N)=O)CC1 by removing a amide.,CC(C)(C)OC(=O)N1CCC(N)(C(N)=O)CC1,amide
+53801,Please remove a hydroxyl from the molecule COc1ccc(COC[C@@H](O)Cn2cnc3ccccc3c2=O)cc1.,COc1ccc(COC[C@@H](O)Cn2cnc3ccccc3c2=O)cc1,hydroxyl
+68499,Modify the molecule CCCNC(=O)[C@@H]1CCCN(C(=O)c2ccc(OC(C)(C)C)cc2)C1 by removing a amide.,CCCNC(=O)[C@@H]1CCCN(C(=O)c2ccc(OC(C)(C)C)cc2)C1,amide
+214657,Modify the molecule O=C(Nc1ccc(F)c(F)c1)[C@H]1Nc2cc(F)ccc2S(=O)(=O)N1 by removing a halo.,O=C(Nc1ccc(F)c(F)c1)[C@H]1Nc2cc(F)ccc2S(=O)(=O)N1,halo
+90812,Remove a hydroxyl from the molecule OCCc1ccc(OC[C@H]2CO2)cc1.,OCCc1ccc(OC[C@H]2CO2)cc1,hydroxyl
+242892,Modify the molecule COC(=O)[C@H](C)NC(=O)[C@@H]1COc2ccc(F)cc2C1 by removing a amide.,COC(=O)[C@H](C)NC(=O)[C@@H]1COc2ccc(F)cc2C1,amide
+221250,Modify the molecule OC[C@]1([NH2+]C2CC2)CC[C@@H](Sc2nc3ccccc3[nH]2)C1 by removing a hydroxyl.,OC[C@]1([NH2+]C2CC2)CC[C@@H](Sc2nc3ccccc3[nH]2)C1,hydroxyl
+119127,Modify the molecule CCc1ccc([C@H]([NH2+][C@@H]2CCO[C@]3(CCSC3)C2)C(C)C)cc1 by removing a benzene_ring.,CCc1ccc([C@H]([NH2+][C@@H]2CCO[C@]3(CCSC3)C2)C(C)C)cc1,benzene_ring
+108791,Remove a benzene_ring from the molecule CCOc1ccc(Nc2nc(-c3cccs3)c(CC(=O)[O-])s2)cc1.,CCOc1ccc(Nc2nc(-c3cccs3)c(CC(=O)[O-])s2)cc1,benzene_ring
+133328,Please remove a amide from the molecule CNC(=O)c1cccc(N[C@H](C)C(=O)N2CCOCC2)c1.,CNC(=O)c1cccc(N[C@H](C)C(=O)N2CCOCC2)c1,amide
+117326,Please remove a benzene_ring from the molecule Cc1ccccc1[C@H]1CC(c2cccc(NS(C)(=O)=O)c2)=NN1C(=O)C1CCCCC1.,Cc1ccccc1[C@H]1CC(c2cccc(NS(C)(=O)=O)c2)=NN1C(=O)C1CCCCC1,benzene_ring
+108225,Modify the molecule C[C@H]1CCCC[C@@H]1NC(=O)COc1cc(O)c2c(c1)OC(C)(C)CC2=O by removing a hydroxyl.,C[C@H]1CCCC[C@@H]1NC(=O)COc1cc(O)c2c(c1)OC(C)(C)CC2=O,hydroxyl
+33854,Remove a benzene_ring from the molecule COc1ccc(NC(=O)CN(C)C(=O)c2cccc(N3CCCC3=O)c2)cc1.,COc1ccc(NC(=O)CN(C)C(=O)c2cccc(N3CCCC3=O)c2)cc1,benzene_ring
+8817,Please remove a benzene_ring from the molecule C[NH2+][C@H](c1ccc(OC)c(OC)c1)[C@H]1CCO[C@H]1C.,C[NH2+][C@H](c1ccc(OC)c(OC)c1)[C@H]1CCO[C@H]1C,benzene_ring
+200665,Remove a benzene_ring from the molecule COc1ccc(C[C@H]([NH3+])c2ccc(OC)cc2)cc1.,COc1ccc(C[C@H]([NH3+])c2ccc(OC)cc2)cc1,benzene_ring
+173106,Remove a benzene_ring from the molecule CO[C@H](CNC(=O)NC[C@@H]1CN2CCCC[C@@H]2CO1)c1ccccc1.,CO[C@H](CNC(=O)NC[C@@H]1CN2CCCC[C@@H]2CO1)c1ccccc1,benzene_ring
+52707,Modify the molecule CC1=C(C(=O)CSc2nnc(C3=c4ccccc4=[NH+]C3)n2C2CC2)C[C@@H](C)N1C1CC1 by removing a amine.,CC1=C(C(=O)CSc2nnc(C3=c4ccccc4=[NH+]C3)n2C2CC2)C[C@@H](C)N1C1CC1,amine
+90296,Remove a halo from the molecule CCN([C@@H](C)CS(=O)(=O)CC)S(=O)(=O)c1c[nH]c2nccc(Cl)c12.,CCN([C@@H](C)CS(=O)(=O)CC)S(=O)(=O)c1c[nH]c2nccc(Cl)c12,halo
+50708,Remove a amide from the molecule CCS(=O)(=O)c1ccccc1C(=O)N1CCO[C@H](C)C1.,CCS(=O)(=O)c1ccccc1C(=O)N1CCO[C@H](C)C1,amide
+106800,Modify the molecule CC(C)Cn1ncc(C(=O)N[C@@H]2CCCn3nc(C(C)C)nc32)c1C1CC1 by removing a amide.,CC(C)Cn1ncc(C(=O)N[C@@H]2CCCn3nc(C(C)C)nc32)c1C1CC1,amide
+111359,Modify the molecule COc1cccc2sc(NC(=O)C[NH+]3CCC[C@@H]([C@@H](C)O)C3)nc12 by removing a amide.,COc1cccc2sc(NC(=O)C[NH+]3CCC[C@@H]([C@@H](C)O)C3)nc12,amide
+42603,Remove a amide from the molecule CCc1ccc2oc(=O)cc(C[NH+]3CCC[C@H](N4CCCC4=O)C3)c2c1.,CCc1ccc2oc(=O)cc(C[NH+]3CCC[C@H](N4CCCC4=O)C3)c2c1,amide
+197349,Please remove a benzene_ring from the molecule Cc1nn(Cc2ccccc2)c(C)c1C[NH+]1CCC[C@H](n2cccn2)C1.,Cc1nn(Cc2ccccc2)c(C)c1C[NH+]1CCC[C@H](n2cccn2)C1,benzene_ring
+244693,Please remove a benzene_ring from the molecule CS(=O)(=O)C1=NN2C(=N)/C(=C\c3ccc(OCc4ccccc4)cc3)C(=O)N=C2S1.,CS(=O)(=O)C1=NN2C(=N)/C(=C\c3ccc(OCc4ccccc4)cc3)C(=O)N=C2S1,benzene_ring
+242830,Modify the molecule CC(=O)Nc1nc(C(=O)N[C@H](C)c2ccccn2)cs1 by removing a amide.,CC(=O)Nc1nc(C(=O)N[C@H](C)c2ccccn2)cs1,amide
+138302,Please remove a amine from the molecule Cc1cccc2c(CCNC(=O)NN[C@@]3(C)CCS(=O)(=O)C3)c[nH]c12.,Cc1cccc2c(CCNC(=O)NN[C@@]3(C)CCS(=O)(=O)C3)c[nH]c12,amine
+18250,Remove a hydroxyl from the molecule CCOC(=O)[C@](C)(O)[C@@H](C)c1cccc2ccccc12.,CCOC(=O)[C@](C)(O)[C@@H](C)c1cccc2ccccc12,hydroxyl
+115393,Modify the molecule COC(=O)c1ccc(CN(C)C(=O)c2oc3ccc(F)cc3c2C)cc1 by removing a benzene_ring.,COC(=O)c1ccc(CN(C)C(=O)c2oc3ccc(F)cc3c2C)cc1,benzene_ring
+205387,Remove a benzene_ring from the molecule O=C(NCCc1cccc(Cl)c1)c1ccc(NS(=O)(=O)c2ccc3[nH]c(=O)[nH]c3c2)cc1.,O=C(NCCc1cccc(Cl)c1)c1ccc(NS(=O)(=O)c2ccc3[nH]c(=O)[nH]c3c2)cc1,benzene_ring
+35191,Remove a amide from the molecule Cc1cc(C)c(O)c(NC(=O)[C@@H]([NH3+])Cc2ccccc2)c1.,Cc1cc(C)c(O)c(NC(=O)[C@@H]([NH3+])Cc2ccccc2)c1,amide
+52703,Please remove a amine from the molecule c1ccc([C@H](NCCc2nnc3n2CCCCC3)C2CCCC2)cc1.,c1ccc([C@H](NCCc2nnc3n2CCCCC3)C2CCCC2)cc1,amine
+134761,Modify the molecule COC(=O)[C@@H](C)[C@H](C)Sc1ccc(N)c(F)c1 by removing a benzene_ring.,COC(=O)[C@@H](C)[C@H](C)Sc1ccc(N)c(F)c1,benzene_ring
+112955,Modify the molecule CCCC(=O)Nc1nn2c(-c3ccc(OC)cc3)nnc2s1 by removing a amide.,CCCC(=O)Nc1nn2c(-c3ccc(OC)cc3)nnc2s1,amide
+198945,Please remove a hydroxyl from the molecule C[C@@H]1CCCC[NH+]1C[C@@H]1CCCN(C(=O)[C@H](O)c2ccccc2)C1.,C[C@@H]1CCCC[NH+]1C[C@@H]1CCCN(C(=O)[C@H](O)c2ccccc2)C1,hydroxyl
+68991,Please remove a benzene_ring from the molecule CCN(C(=O)CN(CCO)c1ccccc1)C1CC1.,CCN(C(=O)CN(CCO)c1ccccc1)C1CC1,benzene_ring
+195060,Please remove a amide from the molecule CCc1ccc([C@@H](C)C(=O)Nc2ccc3[nH]c(=O)[nH]c3c2)cc1.,CCc1ccc([C@@H](C)C(=O)Nc2ccc3[nH]c(=O)[nH]c3c2)cc1,amide
+49678,Remove a benzene_ring from the molecule CCOC(=O)Cc1csc(NC(=O)c2ccc(C(F)(F)F)cc2)n1.,CCOC(=O)Cc1csc(NC(=O)c2ccc(C(F)(F)F)cc2)n1,benzene_ring
+167880,Please remove a amide from the molecule CCN(CC)S(=O)(=O)c1ccc(C(=O)N2CC[C@@H](C)[C@H](O)C2)cc1.,CCN(CC)S(=O)(=O)c1ccc(C(=O)N2CC[C@@H](C)[C@H](O)C2)cc1,amide
+92665,Remove a benzene_ring from the molecule Cc1cc([N-]S(=O)(=O)/C=C/c2ccccc2)no1.,Cc1cc([N-]S(=O)(=O)/C=C/c2ccccc2)no1,benzene_ring
+147062,Please remove a halo from the molecule CN(Cc1cc(Br)cs1)C(=O)C[NH+](CCO)C1CC1.,CN(Cc1cc(Br)cs1)C(=O)C[NH+](CCO)C1CC1,halo
+46045,Modify the molecule CNS(=O)(=O)c1ccc([C@H](C)NCCc2ccccn2)cc1 by removing a amine.,CNS(=O)(=O)c1ccc([C@H](C)NCCc2ccccn2)cc1,amine
+131149,Modify the molecule C[C@H]1C[C@H]1c1ccc(/C=C/C(=O)Nc2ccccc2C(=O)NC2CC2)o1 by removing a amide.,C[C@H]1C[C@H]1c1ccc(/C=C/C(=O)Nc2ccccc2C(=O)NC2CC2)o1,amide
+1005,Modify the molecule C[C@H]([NH2+][C@H](C)CC(=O)N(C)Cc1cccc(Cl)c1)C1CCC1 by removing a benzene_ring.,C[C@H]([NH2+][C@H](C)CC(=O)N(C)Cc1cccc(Cl)c1)C1CCC1,benzene_ring
+47819,Remove a amine from the molecule O=C(Nc1ccc2cn[nH]c2c1)c1csc(Nc2ccccn2)n1.,O=C(Nc1ccc2cn[nH]c2c1)c1csc(Nc2ccccn2)n1,amine
+219660,Remove a amine from the molecule C=CCNc1ccc(S(=O)(=O)N2CCC(C)CC2)cc1[N+](=O)[O-].,C=CCNc1ccc(S(=O)(=O)N2CCC(C)CC2)cc1[N+](=O)[O-],amine
+213773,Please remove a nitrile from the molecule Cn1nc(C(F)(F)F)c(C#N)c1N1CC[NH+](C(c2ccccc2)c2ccccc2)CC1.,Cn1nc(C(F)(F)F)c(C#N)c1N1CC[NH+](C(c2ccccc2)c2ccccc2)CC1,nitrile
+10698,Please remove a benzene_ring from the molecule C[C@@H](Cc1cccs1)NC(=O)C(=O)Nc1cc(F)cc(F)c1.,C[C@@H](Cc1cccs1)NC(=O)C(=O)Nc1cc(F)cc(F)c1,benzene_ring
+107117,Remove a amine from the molecule CCNc1ncnc(Nc2cccc(Br)c2)c1[N+](=O)[O-].,CCNc1ncnc(Nc2cccc(Br)c2)c1[N+](=O)[O-],amine
+171337,Remove a amide from the molecule COc1ccc(OC)c2sc(N(Cc3cccnc3)C(=O)c3c[nH]c4ccccc34)nc12.,COc1ccc(OC)c2sc(N(Cc3cccnc3)C(=O)c3c[nH]c4ccccc34)nc12,amide
+26234,Modify the molecule O=C(Cc1ccc(F)c(F)c1)NC1CC1 by removing a benzene_ring.,O=C(Cc1ccc(F)c(F)c1)NC1CC1,benzene_ring
+124374,Remove a amide from the molecule CCC(=O)Nc1ccc(N2CCN(Cc3nc4ccccc4n3C)CC2)c(Cl)c1.,CCC(=O)Nc1ccc(N2CCN(Cc3nc4ccccc4n3C)CC2)c(Cl)c1,amide
+59134,Modify the molecule CN(CCC#N)C(=O)CN1CC[NH+](C[C@H](O)C(C)(C)C)CC1 by removing a amide.,CN(CCC#N)C(=O)CN1CC[NH+](C[C@H](O)C(C)(C)C)CC1,amide
+189835,Modify the molecule Fc1cc(NCc2nnnn2C2CC2)ccc1Cl by removing a halo.,Fc1cc(NCc2nnnn2C2CC2)ccc1Cl,halo
+154488,Modify the molecule CCCn1c([O-])c(C(=O)NNC(=O)c2ccccc2[N+](=O)[O-])c(=O)c2ccccc21 by removing a amide.,CCCn1c([O-])c(C(=O)NNC(=O)c2ccccc2[N+](=O)[O-])c(=O)c2ccccc21,amide
+190059,Remove a benzene_ring from the molecule COc1ccc(C[NH2+]CCNc2ccc(F)c(Cl)c2)cc1.,COc1ccc(C[NH2+]CCNc2ccc(F)c(Cl)c2)cc1,benzene_ring
+235835,Modify the molecule COc1ccc(Br)cc1[C@H]1C(C#N)=C(N)Oc2cc(C)n(O)c(=O)c21 by removing a benzene_ring.,COc1ccc(Br)cc1[C@H]1C(C#N)=C(N)Oc2cc(C)n(O)c(=O)c21,benzene_ring
+231442,Please remove a amide from the molecule COCc1cccc(NC(=O)N2CCN(C(=O)c3ccco3)CC2)c1.,COCc1cccc(NC(=O)N2CCN(C(=O)c3ccco3)CC2)c1,amide
+199901,Remove a benzene_ring from the molecule COc1cc(C[NH2+]C[C@@H]2CN3CCCC[C@@H]3CO2)c(SC)cc1OC.,COc1cc(C[NH2+]C[C@@H]2CN3CCCC[C@@H]3CO2)c(SC)cc1OC,benzene_ring
+171207,Remove a amide from the molecule O=C(COc1ccc2ccccc2c1)Nc1cccc(C(=O)N2CCCCC2)c1.,O=C(COc1ccc2ccccc2c1)Nc1cccc(C(=O)N2CCCCC2)c1,amide
+170640,Modify the molecule COC(=O)[C@@H](C)N1C(=O)S/C(=C/c2ccc(-c3ccccc3C#N)o2)C1=O by removing a nitrile.,COC(=O)[C@@H](C)N1C(=O)S/C(=C/c2ccc(-c3ccccc3C#N)o2)C1=O,nitrile
+241050,Please remove a amide from the molecule COC(=O)c1cccc2c1CCCN2C(=O)CCCn1cnc2c(C)cccc2c1=O.,COC(=O)c1cccc2c1CCCN2C(=O)CCCn1cnc2c(C)cccc2c1=O,amide
+39027,Remove a amide from the molecule O=C(Nc1ccn(Cc2ccccc2)n1)c1cc(Cl)ccc1Cl.,O=C(Nc1ccn(Cc2ccccc2)n1)c1cc(Cl)ccc1Cl,amide
+124415,Please remove a benzene_ring from the molecule COc1ccc(C(=O)c2coc3ccc(O)c(C[NH+](C)C)c23)cc1.,COc1ccc(C(=O)c2coc3ccc(O)c(C[NH+](C)C)c23)cc1,benzene_ring
+10906,Modify the molecule O=C(Nc1ccc(F)c(F)c1)[C@H]1CCCN(c2ccc(-n3ccnc3)nn2)C1 by removing a benzene_ring.,O=C(Nc1ccc(F)c(F)c1)[C@H]1CCCN(c2ccc(-n3ccnc3)nn2)C1,benzene_ring
+99046,Please remove a hydroxyl from the molecule O=c1c2ccccc2oc2cc3c(c(O)c12)CCCC3.,O=c1c2ccccc2oc2cc3c(c(O)c12)CCCC3,hydroxyl
+233185,Modify the molecule NC1=C(Br)[C@H](C(F)(F)F)N=N1 by removing a halo.,NC1=C(Br)[C@H](C(F)(F)F)N=N1,halo
+141008,Please remove a benzene_ring from the molecule COc1ccccc1C[C@H](C)N(C)C(=O)NC[C@H]1CN2CCCC[C@@H]2CO1.,COc1ccccc1C[C@H](C)N(C)C(=O)NC[C@H]1CN2CCCC[C@@H]2CO1,benzene_ring
+126383,Modify the molecule Nc1ccc(F)c(NC(=O)CC[NH+]2CCCCCCC2)c1 by removing a benzene_ring.,Nc1ccc(F)c(NC(=O)CC[NH+]2CCCCCCC2)c1,benzene_ring
+229003,Please remove a nitrile from the molecule N#C[C@H]1CN(C(=O)c2c(O)cccc2O)CCN1Cc1ccccc1.,N#C[C@H]1CN(C(=O)c2c(O)cccc2O)CCN1Cc1ccccc1,nitrile
+39602,Modify the molecule CCOc1ccc(C(=O)N(Cc2ccco2)c2nc3c(F)cccc3s2)cc1 by removing a benzene_ring.,CCOc1ccc(C(=O)N(Cc2ccco2)c2nc3c(F)cccc3s2)cc1,benzene_ring
+242904,Remove a halo from the molecule Cc1sc(Br)cc1S(=O)(=O)N1CCO[C@@H](C#N)C1.,Cc1sc(Br)cc1S(=O)(=O)N1CCO[C@@H](C#N)C1,halo
+155383,Please remove a nitrile from the molecule N#Cc1cccc(CNC(=O)N(Cc2cccnc2)C[C@H]2CCCO2)c1.,N#Cc1cccc(CNC(=O)N(Cc2cccnc2)C[C@H]2CCCO2)c1,nitrile
+199243,Remove a halo from the molecule N#Cc1nc(-c2ccccc2)c(-c2ccccc2)nc1Cl.,N#Cc1nc(-c2ccccc2)c(-c2ccccc2)nc1Cl,halo
+143897,Modify the molecule Cc1occc1C(=O)[C@@H](C#N)c1nc(-c2ccc(C#N)cc2)cs1 by removing a benzene_ring.,Cc1occc1C(=O)[C@@H](C#N)c1nc(-c2ccc(C#N)cc2)cs1,benzene_ring
+143127,Modify the molecule O=C(CN1C(=O)/C(=C/c2cccs2)SC1=S)Nc1cc(C(=O)[O-])ccc1C(=O)[O-] by removing a benzene_ring.,O=C(CN1C(=O)/C(=C/c2cccs2)SC1=S)Nc1cc(C(=O)[O-])ccc1C(=O)[O-],benzene_ring
+110308,Modify the molecule CC(C)CC1=C[C@H]([C@H]2NN[C@H]3SC(c4ccc5c(c4)OCCO5)=NN23)N=N1 by removing a amine.,CC(C)CC1=C[C@H]([C@H]2NN[C@H]3SC(c4ccc5c(c4)OCCO5)=NN23)N=N1,amine
+74129,Remove a benzene_ring from the molecule CCC[C@H]([NH2+]Cc1ccc(C)cc1)c1ccccc1.,CCC[C@H]([NH2+]Cc1ccc(C)cc1)c1ccccc1,benzene_ring
+29942,Remove a amine from the molecule Cc1nn(-c2nc3c(Cl)c(Cl)ccc3s2)c(C)c1C(=O)NN.,Cc1nn(-c2nc3c(Cl)c(Cl)ccc3s2)c(C)c1C(=O)NN,amine
+19020,Modify the molecule COc1cc(F)c([N+](=O)[O-])c(NCCCc2nnc3n2CCCCC3)c1 by removing a halo.,COc1cc(F)c([N+](=O)[O-])c(NCCCc2nnc3n2CCCCC3)c1,halo
+217105,Modify the molecule CCC[C@@H]1C[C@@H]1NC(=O)c1oc2ccccc2c1C[NH+](C)C by removing a amide.,CCC[C@@H]1C[C@@H]1NC(=O)c1oc2ccccc2c1C[NH+](C)C,amide
+56003,Modify the molecule Cc1nn(C)c(C[C@H]([NH3+])[C@@]2(C)CCCO2)c1Cl by removing a halo.,Cc1nn(C)c(C[C@H]([NH3+])[C@@]2(C)CCCO2)c1Cl,halo
+54221,Remove a benzene_ring from the molecule COc1cccc(F)c1[C@H](C)NC(=O)NCC[NH+]1CCC(OC)CC1.,COc1cccc(F)c1[C@H](C)NC(=O)NCC[NH+]1CCC(OC)CC1,benzene_ring
+152905,Remove a benzene_ring from the molecule COc1cccc(OC)c1OC(=O)Cn1c(=O)sc2ccccc21.,COc1cccc(OC)c1OC(=O)Cn1c(=O)sc2ccccc21,benzene_ring
+53369,Please remove a amide from the molecule CN(CCc1ccccc1)C(=O)c1occc1Br.,CN(CCc1ccccc1)C(=O)c1occc1Br,amide
+188798,Please remove a halo from the molecule CCOc1ccccc1CN(C[C@H]1CCCO1)C(=O)Nc1cccc(Cl)c1.,CCOc1ccccc1CN(C[C@H]1CCCO1)C(=O)Nc1cccc(Cl)c1,halo
+152906,Modify the molecule CCc1nc2c(s1)[C@@H](N(C)C(C)=O)CCC2 by removing a amide.,CCc1nc2c(s1)[C@@H](N(C)C(C)=O)CCC2,amide
+204974,Remove a halo from the molecule C[C@@H]([NH2+]Cc1csc(C2CC2)n1)c1ccc(Cl)s1.,C[C@@H]([NH2+]Cc1csc(C2CC2)n1)c1ccc(Cl)s1,halo
+228105,Modify the molecule CC(C)CNC(=O)CNC(=O)N1Cc2ccccc2N(C)C[C@@H]1C by removing a amide.,CC(C)CNC(=O)CNC(=O)N1Cc2ccccc2N(C)C[C@@H]1C,amide
+78635,Remove a amide from the molecule CCSc1nnc(NC(=O)/C=C/Sc2ccccc2)s1.,CCSc1nnc(NC(=O)/C=C/Sc2ccccc2)s1,amide
+126133,Please remove a nitrile from the molecule CCSCCOC(=O)/C=C/c1cccc(C#N)c1.,CCSCCOC(=O)/C=C/c1cccc(C#N)c1,nitrile
+44212,Please remove a amide from the molecule C[C@H]1CCC[NH+]([C@@H](C)CNC(=O)C(=O)Nc2ccc3[nH]ncc3c2)C1.,C[C@H]1CCC[NH+]([C@@H](C)CNC(=O)C(=O)Nc2ccc3[nH]ncc3c2)C1,amide
+226965,Remove a amide from the molecule CC1=NN[C@H](SCC(=O)Nc2nc(C)cs2)N1C.,CC1=NN[C@H](SCC(=O)Nc2nc(C)cs2)N1C,amide
+228754,Remove a benzene_ring from the molecule N#Cc1ccc(OCc2ccc(C(=O)N=c3[nH]c4ccccc4[nH]3)o2)cc1.,N#Cc1ccc(OCc2ccc(C(=O)N=c3[nH]c4ccccc4[nH]3)o2)cc1,benzene_ring
+80910,Please remove a halo from the molecule CC(C)/C=C/C(=O)N1CCc2nnc(CNC(=O)c3cccc(F)c3)n2CC1.,CC(C)/C=C/C(=O)N1CCc2nnc(CNC(=O)c3cccc(F)c3)n2CC1,halo
+149924,Modify the molecule Cc1cc(C(=O)NCCC/C(N)=N/O)sc1Br by removing a amine.,Cc1cc(C(=O)NCCC/C(N)=N/O)sc1Br,amine
+133900,Please remove a hydroxyl from the molecule Cc1cc(C(=O)N(C)[C@@H](C)C(C)(C)C)sc1C#CCCO.,Cc1cc(C(=O)N(C)[C@@H](C)C(C)(C)C)sc1C#CCCO,hydroxyl
+71703,Please remove a benzene_ring from the molecule CC(C)[NH2+][C@@H]1CC(=O)N(Cc2cccc(F)c2)C1.,CC(C)[NH2+][C@@H]1CC(=O)N(Cc2cccc(F)c2)C1,benzene_ring
+20191,Please remove a nitrile from the molecule CC(C)c1nc([C@H]2CCCN2c2ncc(C#N)cc2Cl)no1.,CC(C)c1nc([C@H]2CCCN2c2ncc(C#N)cc2Cl)no1,nitrile
+37419,Remove a amide from the molecule CC(C)(C)NC(=O)[C@H]1COc2ccccc2O1.,CC(C)(C)NC(=O)[C@H]1COc2ccccc2O1,amide
+200988,Remove a benzene_ring from the molecule Cc1cc([C@H]2[C@@H](C[NH2+]C3CC3)CCCN2C)ccc1Br.,Cc1cc([C@H]2[C@@H](C[NH2+]C3CC3)CCCN2C)ccc1Br,benzene_ring
+158917,Please remove a benzene_ring from the molecule COc1c(C)cc(S(=O)(=O)NCC[C@H](O)C2CC2)cc1C.,COc1c(C)cc(S(=O)(=O)NCC[C@H](O)C2CC2)cc1C,benzene_ring
+152685,Modify the molecule O=C1OCCN1c1cccc(NS(=O)(=O)c2cccc(C(F)(F)F)c2)c1 by removing a halo.,O=C1OCCN1c1cccc(NS(=O)(=O)c2cccc(C(F)(F)F)c2)c1,halo
+98821,Remove a amine from the molecule CC/[NH+]=C(/NCc1nnc2n1CCCCC2)N[C@@H]1C[C@@H]1C.,CC/[NH+]=C(/NCc1nnc2n1CCCCC2)N[C@@H]1C[C@@H]1C,amine
+172186,Remove a halo from the molecule Cc1cc(F)c([C@@H](C)CC[NH3+])cc1F.,Cc1cc(F)c([C@@H](C)CC[NH3+])cc1F,halo
+30686,Remove a halo from the molecule Cc1ccc(NC(=O)[C@@H]2C[C@H]3CC[C@@H]2O3)cc1Br.,Cc1ccc(NC(=O)[C@@H]2C[C@H]3CC[C@@H]2O3)cc1Br,halo
+20514,Remove a amide from the molecule COCC(=O)N1CCCN(Cc2cnc(-c3ccccn3)nc2)CC1.,COCC(=O)N1CCCN(Cc2cnc(-c3ccccn3)nc2)CC1,amide
+151517,Please remove a amide from the molecule CN1C[C@@H](NC(=O)NCc2ccnc(OC3CCC3)c2)CCC1=O.,CN1C[C@@H](NC(=O)NCc2ccnc(OC3CCC3)c2)CCC1=O,amide
+34842,Please remove a amide from the molecule CC(C)[C@@H](NC(=O)C(=O)Nc1cccc(-c2ncon2)c1)c1ccccn1.,CC(C)[C@@H](NC(=O)C(=O)Nc1cccc(-c2ncon2)c1)c1ccccn1,amide
+108153,Modify the molecule O=C(NNC(=S)[S-])c1cnccn1 by removing a amine.,O=C(NNC(=S)[S-])c1cnccn1,amine
+25001,Modify the molecule O=c1c(-c2nccs2)nc2ccc(NCc3c(F)cccc3F)nc2n1Cc1ccncc1 by removing a halo.,O=c1c(-c2nccs2)nc2ccc(NCc3c(F)cccc3F)nc2n1Cc1ccncc1,halo
+220339,Remove a benzene_ring from the molecule CCc1ccc(C[NH2+]Cc2ccccc2)cc1.,CCc1ccc(C[NH2+]Cc2ccccc2)cc1,benzene_ring
+206890,Modify the molecule C[C@@H](SCc1ccccc1)C(=O)NC[C@@H](C)N1CC[NH+](C)CC1 by removing a benzene_ring.,C[C@@H](SCc1ccccc1)C(=O)NC[C@@H](C)N1CC[NH+](C)CC1,benzene_ring
+66611,Please remove a halo from the molecule CSCc1cc(F)ccc1CNC(=O)c1c(F)cccc1Cl.,CSCc1cc(F)ccc1CNC(=O)c1c(F)cccc1Cl,halo
+245427,Modify the molecule C[C@H]1C[C@@H]1NC(=O)c1c[nH]nc1-c1cccc(OC(F)F)c1 by removing a amide.,C[C@H]1C[C@@H]1NC(=O)c1c[nH]nc1-c1cccc(OC(F)F)c1,amide
+244919,Please remove a amine from the molecule COc1ccc(OC)c(NS(=O)(=O)c2ccc(CC(C)C)cc2)c1.,COc1ccc(OC)c(NS(=O)(=O)c2ccc(CC(C)C)cc2)c1,amine
+123382,Modify the molecule Cc1ccc(NC(=O)[C@H](C)Cc2cccc(C(F)(F)F)c2)cc1C(N)=O by removing a benzene_ring.,Cc1ccc(NC(=O)[C@H](C)Cc2cccc(C(F)(F)F)c2)cc1C(N)=O,benzene_ring
+140818,Please remove a amide from the molecule COc1cc(NC(=O)c2cc(C)cc(C)c2)c(OC)cc1NC(=O)c1ccccc1.,COc1cc(NC(=O)c2cc(C)cc(C)c2)c(OC)cc1NC(=O)c1ccccc1,amide
+192378,Please remove a halo from the molecule Cc1cccc(-n2c(C)cc(C(=O)C(=O)Nc3ccccc3F)c2C)c1C.,Cc1cccc(-n2c(C)cc(C(=O)C(=O)Nc3ccccc3F)c2C)c1C,halo
+66648,Modify the molecule CC(=O)Nc1nc(SCC(=O)N2C[C@H](C)O[C@H](C)C2)[nH]c(=O)c1NC(=O)c1ccccc1 by removing a amide.,CC(=O)Nc1nc(SCC(=O)N2C[C@H](C)O[C@H](C)C2)[nH]c(=O)c1NC(=O)c1ccccc1,amide
+61847,Modify the molecule Cc1cncc(C(=O)N2CCCc3cc(C)ccc32)c1 by removing a amide.,Cc1cncc(C(=O)N2CCCc3cc(C)ccc32)c1,amide
+160161,Modify the molecule O=C(C1CCN([C@H]2CCS(=O)(=O)C2)CC1)N1CCN(Cc2ccc3c(c2)CCO3)CC1 by removing a amide.,O=C(C1CCN([C@H]2CCS(=O)(=O)C2)CC1)N1CCN(Cc2ccc3c(c2)CCO3)CC1,amide
+115968,Remove a benzene_ring from the molecule Cn1c(SC(c2ccccc2)c2ccccc2)nnc1[C@H]1COc2ccccc2O1.,Cn1c(SC(c2ccccc2)c2ccccc2)nnc1[C@H]1COc2ccccc2O1,benzene_ring
+202906,Please remove a benzene_ring from the molecule CC(=O)Nc1cccc([C@H](C)NC(=O)CCc2ncc(-c3ccc(C)c(C)c3)o2)c1.,CC(=O)Nc1cccc([C@H](C)NC(=O)CCc2ncc(-c3ccc(C)c(C)c3)o2)c1,benzene_ring
+185711,Please remove a halo from the molecule CC(C)(C)OC(=O)c1nc([O-])n(-c2ccc(Br)cc2)n1.,CC(C)(C)OC(=O)c1nc([O-])n(-c2ccc(Br)cc2)n1,halo
+125072,Remove a amide from the molecule CC(C)(C#N)CCCNc1ccccc1C(=O)N1CCC[C@@H]1CO.,CC(C)(C#N)CCCNc1ccccc1C(=O)N1CCC[C@@H]1CO,amide
+104792,Remove a benzene_ring from the molecule N#Cc1csc(C(=O)NCc2cccc(NC(=O)C3CCCC3)c2)c1.,N#Cc1csc(C(=O)NCc2cccc(NC(=O)C3CCCC3)c2)c1,benzene_ring
+97535,Please remove a amide from the molecule Cn1nc(C(F)(F)F)c2cc(C(=O)N3C[C@@H]4CC[C@H](C3)[NH+](C)C4)sc21.,Cn1nc(C(F)(F)F)c2cc(C(=O)N3C[C@@H]4CC[C@H](C3)[NH+](C)C4)sc21,amide
+170009,Remove a benzene_ring from the molecule COc1ccc(F)c(N2C(=O)CNC(=O)[C@@H]2C(C)C)c1.,COc1ccc(F)c(N2C(=O)CNC(=O)[C@@H]2C(C)C)c1,benzene_ring
+108540,Modify the molecule CNS(=O)(=O)c1ccc(N(C)Cc2ccc(Br)cc2)c([N+](=O)[O-])c1 by removing a halo.,CNS(=O)(=O)c1ccc(N(C)Cc2ccc(Br)cc2)c([N+](=O)[O-])c1,halo
+175244,Modify the molecule CC(C)OCCCNC(=O)C1CCN(C(=O)[C@@H]2CCO[C@H]2C)CC1 by removing a amide.,CC(C)OCCCNC(=O)C1CCN(C(=O)[C@@H]2CCO[C@H]2C)CC1,amide
+188811,Modify the molecule CC(C)N(C)C(=O)CCc1nnc(-c2ccsc2)o1 by removing a amide.,CC(C)N(C)C(=O)CCc1nnc(-c2ccsc2)o1,amide
+237720,Modify the molecule O=C(NCc1ccncc1)N(Cc1ccc(O)cc1)CC1CC1 by removing a hydroxyl.,O=C(NCc1ccncc1)N(Cc1ccc(O)cc1)CC1CC1,hydroxyl
+14669,Remove a amine from the molecule COc1ccccc1CNc1nc2ccc(Cl)cc2nc1-n1nc(C)cc1C.,COc1ccccc1CNc1nc2ccc(Cl)cc2nc1-n1nc(C)cc1C,amine
+238505,Remove a benzene_ring from the molecule COc1ccc(C2=N[C@H](c3ccc(F)c(Br)c3)N[C@H](c3ccccc3O)C2)cc1.,COc1ccc(C2=N[C@H](c3ccc(F)c(Br)c3)N[C@H](c3ccccc3O)C2)cc1,benzene_ring
+95571,Modify the molecule Cc1cc(C)c(C(=O)NCCNc2ccccc2)c(=O)[nH]1 by removing a amine.,Cc1cc(C)c(C(=O)NCCNc2ccccc2)c(=O)[nH]1,amine
+179431,Modify the molecule Cc1cc(CC(=O)Nc2ccc(C#N)c(C(F)(F)F)c2)no1 by removing a benzene_ring.,Cc1cc(CC(=O)Nc2ccc(C#N)c(C(F)(F)F)c2)no1,benzene_ring
+181747,Remove a benzene_ring from the molecule CCOc1c(F)cccc1C(=O)Nc1ccc(-n2ccnc2)cc1.,CCOc1c(F)cccc1C(=O)Nc1ccc(-n2ccnc2)cc1,benzene_ring
+243505,Modify the molecule Nc1nc(C(=O)Nc2ccccc2)cs1 by removing a amine.,Nc1nc(C(=O)Nc2ccccc2)cs1,amine
+226142,Modify the molecule CC(C)(C)[C@](O)(Cn1cncn1)[C@@H]1O[C@@H]1c1ccc(Cl)cc1 by removing a hydroxyl.,CC(C)(C)[C@](O)(Cn1cncn1)[C@@H]1O[C@@H]1c1ccc(Cl)cc1,hydroxyl
+83388,Modify the molecule O=C(Nc1ccc2[nH]ccc2c1)C(=O)N[C@@H](c1nccs1)C1CC1 by removing a amide.,O=C(Nc1ccc2[nH]ccc2c1)C(=O)N[C@@H](c1nccs1)C1CC1,amide
+245383,Remove a benzene_ring from the molecule C[C@H](C[NH+](C)CC(C)(C)S(C)(=O)=O)c1cccc(Br)c1.,C[C@H](C[NH+](C)CC(C)(C)S(C)(=O)=O)c1cccc(Br)c1,benzene_ring
+32010,Modify the molecule Cc1ccc(N2C[C@H](C(=O)N3CC[C@H](c4ccccc4)C3)CC2=O)cc1 by removing a benzene_ring.,Cc1ccc(N2C[C@H](C(=O)N3CC[C@H](c4ccccc4)C3)CC2=O)cc1,benzene_ring
+55338,Remove a amide from the molecule CNC(=O)C[NH+](C)Cc1cc(Cl)cc(Cl)c1.,CNC(=O)C[NH+](C)Cc1cc(Cl)cc(Cl)c1,amide
+209866,Please remove a amide from the molecule Cc1ccc(C(=O)N(C)Cc2nnn[n-]2)cc1.,Cc1ccc(C(=O)N(C)Cc2nnn[n-]2)cc1,amide
+75739,Modify the molecule COc1ccc(CNC(=O)N[C@@H]2C=C[C@H](CO)C2)c(OC2CCCC2)c1 by removing a benzene_ring.,COc1ccc(CNC(=O)N[C@@H]2C=C[C@H](CO)C2)c(OC2CCCC2)c1,benzene_ring
+199713,Remove a halo from the molecule CN(Cc1ccccc1C(F)(F)F)C(=O)NCCc1cccc(F)c1.,CN(Cc1ccccc1C(F)(F)F)C(=O)NCCc1cccc(F)c1,halo
+27706,Please remove a halo from the molecule C[C@H]1C[C@@H](N2CCN(c3cccc(Cl)c3)CC2)C(=O)O1.,C[C@H]1C[C@@H](N2CCN(c3cccc(Cl)c3)CC2)C(=O)O1,halo
+75672,Remove a benzene_ring from the molecule C[C@@H]1CCCC[C@@H]1[NH+](C)Cc1cc(F)cc(C#CC[NH3+])c1.,C[C@@H]1CCCC[C@@H]1[NH+](C)Cc1cc(F)cc(C#CC[NH3+])c1,benzene_ring
+172801,Remove a amide from the molecule Cc1ccc(N2CCn3c2nnc(C(=O)NCc2cccs2)c3=O)cc1.,Cc1ccc(N2CCn3c2nnc(C(=O)NCc2cccs2)c3=O)cc1,amide
+83727,Please remove a amide from the molecule COc1ccc(Cl)cc1NC(=O)[C@@H]1CN(C(C)=O)c2ccccc2O1.,COc1ccc(Cl)cc1NC(=O)[C@@H]1CN(C(C)=O)c2ccccc2O1,amide
+203696,Modify the molecule CCn1nnnc1-c1ccc(OC)c(S(=O)(=O)Nc2ccc(C)c(C)c2)c1 by removing a amine.,CCn1nnnc1-c1ccc(OC)c(S(=O)(=O)Nc2ccc(C)c(C)c2)c1,amine
+80906,Please remove a amide from the molecule Cc1noc(C)c1S(=O)(=O)NCCNC(=O)c1cccn1C.,Cc1noc(C)c1S(=O)(=O)NCCNC(=O)c1cccn1C,amide
+810,Modify the molecule O=C(Nc1ccccc1)NC1CCN(C(=O)[C@H]2CCCC[C@H]2C(F)(F)F)CC1 by removing a amide.,O=C(Nc1ccccc1)NC1CCN(C(=O)[C@H]2CCCC[C@H]2C(F)(F)F)CC1,amide
+137152,Please remove a hydroxyl from the molecule C[C@H]1CCN(C(=O)COc2ccccc2Br)C[C@H]1O.,C[C@H]1CCN(C(=O)COc2ccccc2Br)C[C@H]1O,hydroxyl
+143959,Please remove a benzene_ring from the molecule CCOc1cccnc1C(=O)O[C@@H](C)c1cccc(OC)c1.,CCOc1cccnc1C(=O)O[C@@H](C)c1cccc(OC)c1,benzene_ring
+170455,Modify the molecule C[C@@H](N[C@H](c1cccnc1)c1ccc(F)c(F)c1)c1cnn(C)c1 by removing a benzene_ring.,C[C@@H](N[C@H](c1cccnc1)c1ccc(F)c(F)c1)c1cnn(C)c1,benzene_ring
+239448,Remove a benzene_ring from the molecule COC(=O)CNC(=O)CCN1CCO[C@@H](c2ccccc2Br)C1.,COC(=O)CNC(=O)CCN1CCO[C@@H](c2ccccc2Br)C1,benzene_ring
+74853,Remove a benzene_ring from the molecule Cc1cc(N(C)C)cc(C)c1NC(=O)CCn1cnc2ccccc21.,Cc1cc(N(C)C)cc(C)c1NC(=O)CCn1cnc2ccccc21,benzene_ring
+4182,Remove a amide from the molecule COCCNC(=O)[C@@H](C)CS(=O)(=O)c1ccc(Br)cc1.,COCCNC(=O)[C@@H](C)CS(=O)(=O)c1ccc(Br)cc1,amide
+36912,Remove a benzene_ring from the molecule COc1ccc(NC(=O)Cn2cnc(C3CCC3)cc2=O)c([N+](=O)[O-])c1.,COc1ccc(NC(=O)Cn2cnc(C3CCC3)cc2=O)c([N+](=O)[O-])c1,benzene_ring
+115180,Please remove a amide from the molecule C[C@@H](c1nc2ccccc2s1)N(C)C(=O)c1cccc(Nc2ncccn2)c1.,C[C@@H](c1nc2ccccc2s1)N(C)C(=O)c1cccc(Nc2ncccn2)c1,amide
+36740,Please remove a benzene_ring from the molecule N#C[C@@H]1CCC[C@H]1Sc1ccccc1Br.,N#C[C@@H]1CCC[C@H]1Sc1ccccc1Br,benzene_ring
+183095,Remove a amide from the molecule C[C@@H](c1cccnc1)N(C)C(=O)Nc1ccn(CCCC(=O)N(C)C)n1.,C[C@@H](c1cccnc1)N(C)C(=O)Nc1ccn(CCCC(=O)N(C)C)n1,amide
+4357,Please remove a amide from the molecule NC(=O)c1cc([N+](=O)[O-])ccc1O[C@H]1CCC[C@@H]([NH3+])C1.,NC(=O)c1cc([N+](=O)[O-])ccc1O[C@H]1CCC[C@@H]([NH3+])C1,amide
+249133,Modify the molecule COc1ccc(/C=C2\CCCc3c2nc2ccccc2c3C(=O)OCC(N)=O)cc1 by removing a amide.,COc1ccc(/C=C2\CCCc3c2nc2ccccc2c3C(=O)OCC(N)=O)cc1,amide
+60971,Modify the molecule CCO[C@H]1C[C@@H](NC(=O)C(=O)Nc2cc(C(C)C)on2)C12CCCC2 by removing a amide.,CCO[C@H]1C[C@@H](NC(=O)C(=O)Nc2cc(C(C)C)on2)C12CCCC2,amide
+233071,Modify the molecule C[C@@H](NC(=O)c1ccc(Cl)cc1)C(=O)Nc1ccc(N2CC[NH+](C)CC2)nc1 by removing a halo.,C[C@@H](NC(=O)c1ccc(Cl)cc1)C(=O)Nc1ccc(N2CC[NH+](C)CC2)nc1,halo
+200537,Modify the molecule O=C(Nc1cc(F)ccc1F)[C@H]1CCS(=O)(=O)C1 by removing a halo.,O=C(Nc1cc(F)ccc1F)[C@H]1CCS(=O)(=O)C1,halo
+243683,Remove a amide from the molecule CO[C@@H](C)C(=O)Nc1cccc(NS(=O)(=O)c2cc(C)ccc2F)c1.,CO[C@@H](C)C(=O)Nc1cccc(NS(=O)(=O)c2cc(C)ccc2F)c1,amide
+145495,Modify the molecule C[NH2+]C[C@H](C)C(=O)NC[C@H]1CCC(=O)N1 by removing a amide.,C[NH2+]C[C@H](C)C(=O)NC[C@H]1CCC(=O)N1,amide
+209480,Please remove a amine from the molecule CN/C(=[NH+]\C)SCC(=O)N(C)Cc1ccc(Cl)s1.,CN/C(=[NH+]\C)SCC(=O)N(C)Cc1ccc(Cl)s1,amine
+229002,Remove a amide from the molecule C[C@H]1C[C@@H]1c1ccc(CN(C)C(=O)c2ccc(NC(N)=O)cc2)o1.,C[C@H]1C[C@@H]1c1ccc(CN(C)C(=O)c2ccc(NC(N)=O)cc2)o1,amide
+38809,Modify the molecule O=C([O-])[C@H]1CCCCN1C(=O)c1nc(C2CC2)n[nH]1 by removing a amide.,O=C([O-])[C@H]1CCCCN1C(=O)c1nc(C2CC2)n[nH]1,amide
+141594,Modify the molecule CCN(C(=O)c1cccc(C(F)(F)F)c1F)C1C[NH2+]C1 by removing a amide.,CCN(C(=O)c1cccc(C(F)(F)F)c1F)C1C[NH2+]C1,amide
+55697,Please remove a amide from the molecule COc1ccc(-c2ccc(=O)n([C@@H](C)C(=O)Nc3ccc(OC)c(OC)c3)n2)cc1.,COc1ccc(-c2ccc(=O)n([C@@H](C)C(=O)Nc3ccc(OC)c(OC)c3)n2)cc1,amide
+194457,Remove a hydroxyl from the molecule CC[C@@H](CO)N1CC[NH+](C2CCC(C(C)C)CC2)CC1.,CC[C@@H](CO)N1CC[NH+](C2CCC(C(C)C)CC2)CC1,hydroxyl
+232000,Modify the molecule Cc1cc(-c2c(-c3ccccc3)ncn2CCCO)cc(C)c1O by removing a benzene_ring.,Cc1cc(-c2c(-c3ccccc3)ncn2CCCO)cc(C)c1O,benzene_ring
+120031,Remove a amide from the molecule CC(C)c1n[nH]c([C@H]2CN(C(=O)c3ccc(=O)n(C)n3)CCO2)n1.,CC(C)c1n[nH]c([C@H]2CN(C(=O)c3ccc(=O)n(C)n3)CCO2)n1,amide
+17279,Modify the molecule Cc1cc(N2CC[C@@H](N[C@H](C)c3cccnc3Cl)C2=O)n(C)n1 by removing a amine.,Cc1cc(N2CC[C@@H](N[C@H](C)c3cccnc3Cl)C2=O)n(C)n1,amine
+149249,Please remove a halo from the molecule COc1ccc(CC(=O)NCc2ccccc2F)cc1OC.,COc1ccc(CC(=O)NCc2ccccc2F)cc1OC,halo
+148976,Modify the molecule CCOC(=O)c1c(NC(=O)CSc2n[nH]c(N)n2)sc2c1CC[C@H](C)C2 by removing a amide.,CCOC(=O)c1c(NC(=O)CSc2n[nH]c(N)n2)sc2c1CC[C@H](C)C2,amide
+208090,Please remove a benzene_ring from the molecule O=c1c(Cc2ccc(Cl)cc2)c([O-])ccn1Cc1ccccc1.,O=c1c(Cc2ccc(Cl)cc2)c([O-])ccn1Cc1ccccc1,benzene_ring
+63264,Modify the molecule Cc1ccccc1[C@H]1CN(C(=O)C(=O)Nc2ccc(F)cc2F)CCO1 by removing a amide.,Cc1ccccc1[C@H]1CN(C(=O)C(=O)Nc2ccc(F)cc2F)CCO1,amide
+133571,Modify the molecule C[C@@H](Cc1nc2ccccc2s1)N[C@H](C)c1cn(-c2ccccc2)nn1 by removing a benzene_ring.,C[C@@H](Cc1nc2ccccc2s1)N[C@H](C)c1cn(-c2ccccc2)nn1,benzene_ring
+234871,Please remove a benzene_ring from the molecule CC[S@](=O)[C@@H]1CCCC[C@@H]1NC(=O)NC(C)(C)c1cccc(C)c1.,CC[S@](=O)[C@@H]1CCCC[C@@H]1NC(=O)NC(C)(C)c1cccc(C)c1,benzene_ring
+109403,Modify the molecule Fc1ccc(OCC2=NN3[C@@H]([C@H]4C=c5ccccc5=[NH+]4)NN[C@H]3S2)cc1 by removing a amine.,Fc1ccc(OCC2=NN3[C@@H]([C@H]4C=c5ccccc5=[NH+]4)NN[C@H]3S2)cc1,amine
+105219,Modify the molecule Cc1ccc(S(=O)(=O)N(C)c2ccc(O[C@H](C)C(=O)Nc3c(C)cc(C)cc3C)cc2)cc1 by removing a benzene_ring.,Cc1ccc(S(=O)(=O)N(C)c2ccc(O[C@H](C)C(=O)Nc3c(C)cc(C)cc3C)cc2)cc1,benzene_ring
+23956,Modify the molecule Cc1ccc(NC(=S)NC(=O)c2ccccc2[N+](=O)[O-])c(C)c1 by removing a benzene_ring.,Cc1ccc(NC(=S)NC(=O)c2ccccc2[N+](=O)[O-])c(C)c1,benzene_ring
+71959,Modify the molecule Cn1c(N2CC[C@H](O)C2)nc2cc(C(=O)NCCCOc3ccccc3)ccc21 by removing a amide.,Cn1c(N2CC[C@H](O)C2)nc2cc(C(=O)NCCCOc3ccccc3)ccc21,amide
+107238,Modify the molecule O=C(/C=C/c1ccc(F)cc1)NC(=S)NNS(=O)(=O)c1ccccc1 by removing a amide.,O=C(/C=C/c1ccc(F)cc1)NC(=S)NNS(=O)(=O)c1ccccc1,amide
+117390,Modify the molecule CNC(=O)CN1CCC([NH2+][C@@H](c2c(Cl)cccc2Cl)C(C)C)CC1 by removing a benzene_ring.,CNC(=O)CN1CCC([NH2+][C@@H](c2c(Cl)cccc2Cl)C(C)C)CC1,benzene_ring
+105500,Please remove a benzene_ring from the molecule COc1cc(CN(C)C[C@H](O)CN2CCOCC2)cc(Br)c1O.,COc1cc(CN(C)C[C@H](O)CN2CCOCC2)cc(Br)c1O,benzene_ring
+89300,Please remove a amide from the molecule COC(=O)CN(C(=O)c1cnc([C@@H]2CCCO2)s1)c1cccc(F)c1.,COC(=O)CN(C(=O)c1cnc([C@@H]2CCCO2)s1)c1cccc(F)c1,amide
+8140,Remove a amine from the molecule Cc1ccc(NC(=O)[C@@H](Sc2nnc(-c3cccnc3)n2N)c2ccccc2)cc1.,Cc1ccc(NC(=O)[C@@H](Sc2nnc(-c3cccnc3)n2N)c2ccccc2)cc1,amine
+130924,Please remove a amide from the molecule Cn1c(-c2ccccn2)nn(CCNC(=O)c2ccco2)c1=O.,Cn1c(-c2ccccn2)nn(CCNC(=O)c2ccco2)c1=O,amide
+93496,Please remove a benzene_ring from the molecule Cc1ccc([C@@H]2C3=C([O-])CCCC3=NC3=NC(SCC(=O)NCc4ccccc4)=NC(=O)[C@H]32)cc1.,Cc1ccc([C@@H]2C3=C([O-])CCCC3=NC3=NC(SCC(=O)NCc4ccccc4)=NC(=O)[C@H]32)cc1,benzene_ring
+218148,Modify the molecule COc1ccc(OC)c(NC(=O)[C@H]2C[C@H](CCSC)N[C@]23C(=O)Nc2c(C)cc(Cl)cc23)c1 by removing a amine.,COc1ccc(OC)c(NC(=O)[C@H]2C[C@H](CCSC)N[C@]23C(=O)Nc2c(C)cc(Cl)cc23)c1,amine
+54295,Please remove a halo from the molecule OC[C@H]1C[C@@H]1c1ccccc1Cl.,OC[C@H]1C[C@@H]1c1ccccc1Cl,halo
+73447,Modify the molecule C[C@H]1CCC[C@H](C)C1NC(=O)/C=C/c1ccc(N2CCCS2(=O)=O)cc1 by removing a amide.,C[C@H]1CCC[C@H](C)C1NC(=O)/C=C/c1ccc(N2CCCS2(=O)=O)cc1,amide
+47742,Please remove a halo from the molecule CCc1nc(CC[NH2+]Cc2cc(=O)c3cc(F)ccc3[nH]2)cs1.,CCc1nc(CC[NH2+]Cc2cc(=O)c3cc(F)ccc3[nH]2)cs1,halo
+59428,Modify the molecule CC(=O)N1C=Cc2ccccc2[C@H]1CC(=O)NC[C@H](CC(C)C)[NH+](C)C by removing a amide.,CC(=O)N1C=Cc2ccccc2[C@H]1CC(=O)NC[C@H](CC(C)C)[NH+](C)C,amide
+55436,Please remove a benzene_ring from the molecule C[C@@H](C(=O)N(C)C1CCCCC1)n1nnc(-c2ccccc2)n1.,C[C@@H](C(=O)N(C)C1CCCCC1)n1nnc(-c2ccccc2)n1,benzene_ring
+174828,Please remove a amine from the molecule CCCN[C@@]1(C(=O)[O-])CC[C@H]([NH+]2CCC[C@@H]2C)C1.,CCCN[C@@]1(C(=O)[O-])CC[C@H]([NH+]2CCC[C@@H]2C)C1,amine
+233722,Please remove a halo from the molecule C[C@H](SCc1ccnn1C)c1ccc(F)c(F)c1.,C[C@H](SCc1ccnn1C)c1ccc(F)c(F)c1,halo
+111672,Please remove a benzene_ring from the molecule COc1cc(OC)cc([C@@H]2CCN(C(=O)N[C@@H]3C[C@@H]3c3ccccc3)C2)c1.,COc1cc(OC)cc([C@@H]2CCN(C(=O)N[C@@H]3C[C@@H]3c3ccccc3)C2)c1,benzene_ring
+112674,Please remove a benzene_ring from the molecule COc1cc2c(cc1OC)C[NH+](Cn1nc(-c3ccc(Cl)cc3)n(C)c1=S)CC2.,COc1cc2c(cc1OC)C[NH+](Cn1nc(-c3ccc(Cl)cc3)n(C)c1=S)CC2,benzene_ring
+1518,Remove a amide from the molecule CCc1nc(C)sc1CNC(=O)CCc1nc(-c2ccccc2C)no1.,CCc1nc(C)sc1CNC(=O)CCc1nc(-c2ccccc2C)no1,amide
+114196,Please remove a amide from the molecule Cc1ccc(S(=O)(=O)[C@H](C)C(=O)Nc2c(C)cccc2C)cc1C.,Cc1ccc(S(=O)(=O)[C@H](C)C(=O)Nc2c(C)cccc2C)cc1C,amide
+50658,Modify the molecule Cc1ccc(N2CC[C@H](Nc3ccc([N+](=O)[O-])nc3)C2=O)cc1 by removing a benzene_ring.,Cc1ccc(N2CC[C@H](Nc3ccc([N+](=O)[O-])nc3)C2=O)cc1,benzene_ring
+26161,Remove a nitrile from the molecule CC(C)[C@@H](NC(=O)/C=C/c1ccc(OCC#N)cc1)c1ccccn1.,CC(C)[C@@H](NC(=O)/C=C/c1ccc(OCC#N)cc1)c1ccccn1,nitrile
+201943,Remove a hydroxyl from the molecule C[C@H](C/C(N)=N/O)N1CC[NH+]2CCC[C@@H]2C1.,C[C@H](C/C(N)=N/O)N1CC[NH+]2CCC[C@@H]2C1,hydroxyl
+172184,Remove a benzene_ring from the molecule Cc1nc(CNc2ccccc2OC[C@H]2CCCCO2)sc1C.,Cc1nc(CNc2ccccc2OC[C@H]2CCCCO2)sc1C,benzene_ring
+61402,Modify the molecule COc1cccc([C@@H](CNC(=O)Nc2ccc(C(N)=O)c(C)c2)[NH+](C)C)c1 by removing a benzene_ring.,COc1cccc([C@@H](CNC(=O)Nc2ccc(C(N)=O)c(C)c2)[NH+](C)C)c1,benzene_ring
+135923,Please remove a amide from the molecule CC(C)(C)c1ncc(NC(=O)Cc2csc(-c3cnccn3)n2)cn1.,CC(C)(C)c1ncc(NC(=O)Cc2csc(-c3cnccn3)n2)cn1,amide
+158957,Modify the molecule O=C(NCCC(=O)N1CCN(S(=O)(=O)c2ccc(Cl)cc2)CC1)Nc1ccccc1 by removing a halo.,O=C(NCCC(=O)N1CCN(S(=O)(=O)c2ccc(Cl)cc2)CC1)Nc1ccccc1,halo
+179455,Remove a benzene_ring from the molecule Cc1n[nH]c(SCCC(=O)NCc2ccc(N(C)C)cc2C)n1.,Cc1n[nH]c(SCCC(=O)NCc2ccc(N(C)C)cc2C)n1,benzene_ring
+131661,Please remove a amide from the molecule Cc1cc(C(=O)NCCCSc2nccs2)c(C)o1.,Cc1cc(C(=O)NCCCSc2nccs2)c(C)o1,amide
+54088,Remove a benzene_ring from the molecule COc1ccc(C[C@H]([NH3+])Cc2ccc(O)cc2)cn1.,COc1ccc(C[C@H]([NH3+])Cc2ccc(O)cc2)cn1,benzene_ring
+165631,Please remove a amide from the molecule O=C(N[C@@H](C(=O)N/N=C\C=C\c1ccccc1)c1n[nH]c(=O)c2ccccc12)c1ccccc1.,O=C(N[C@@H](C(=O)N/N=C\C=C\c1ccccc1)c1n[nH]c(=O)c2ccccc12)c1ccccc1,amide
+12069,Modify the molecule C[NH+]1CCN(C[C@@H](O)COc2cccc(C[NH3+])c2)CC1 by removing a benzene_ring.,C[NH+]1CCN(C[C@@H](O)COc2cccc(C[NH3+])c2)CC1,benzene_ring
+38815,Please remove a benzene_ring from the molecule CC[NH2+][C@@H](C(C)C)[C@H](C)c1cc(C)ccc1C.,CC[NH2+][C@@H](C(C)C)[C@H](C)c1cc(C)ccc1C,benzene_ring
+208100,Modify the molecule CCCc1cc(NC(=O)N(C)Cc2ccc(F)cc2Cl)n(C)n1 by removing a halo.,CCCc1cc(NC(=O)N(C)Cc2ccc(F)cc2Cl)n(C)n1,halo
+1927,Remove a amide from the molecule Cc1nc(-c2cccc(Cl)c2)sc1C(=O)N[C@H]1CC[C@@H]([NH+](C)C)C1.,Cc1nc(-c2cccc(Cl)c2)sc1C(=O)N[C@H]1CC[C@@H]([NH+](C)C)C1,amide
+162996,Modify the molecule COc1ccc(CN2CC[NH+](Cc3cccc(C)c3)CC2)cc1Br by removing a benzene_ring.,COc1ccc(CN2CC[NH+](Cc3cccc(C)c3)CC2)cc1Br,benzene_ring
+114197,Modify the molecule CCn1nc(C)c(NC(=O)C[C@H]2Oc3ccccc3NC2=O)c1C by removing a amide.,CCn1nc(C)c(NC(=O)C[C@H]2Oc3ccccc3NC2=O)c1C,amide
+76779,Remove a amide from the molecule CCc1nn(C)cc1NC(=O)CCn1c(C)csc1=O.,CCc1nn(C)cc1NC(=O)CCn1c(C)csc1=O,amide
+35000,Remove a amide from the molecule COC(CNC(=O)CN1CC[NH2+]CC1)OC.,COC(CNC(=O)CN1CC[NH2+]CC1)OC,amide
+140664,Modify the molecule Cc1cc(C)cc(O[C@@H](C)C(=O)N(Cc2ccc(F)cc2)[C@@H]2CCS(=O)(=O)C2)c1 by removing a halo.,Cc1cc(C)cc(O[C@@H](C)C(=O)N(Cc2ccc(F)cc2)[C@@H]2CCS(=O)(=O)C2)c1,halo
+88597,Please remove a benzene_ring from the molecule O=C(NCC[NH+]1CCC(c2ccsc2)CC1)c1ccc(F)cc1Cl.,O=C(NCC[NH+]1CCC(c2ccsc2)CC1)c1ccc(F)cc1Cl,benzene_ring
+196700,Remove a amide from the molecule Cc1cc(C)cc(-n2cc(C(=O)N3CCC(C)CC3)nn2)c1.,Cc1cc(C)cc(-n2cc(C(=O)N3CCC(C)CC3)nn2)c1,amide
+167343,Remove a amine from the molecule COc1ccc(/C=[NH+]\C[C@H]2COc3ccccc3O2)c(OC)c1.,COc1ccc(/C=[NH+]\C[C@H]2COc3ccccc3O2)c(OC)c1,amine
+238279,Remove a benzene_ring from the molecule CO[C@H]1CCCN(C(=O)N[C@@H](C)c2cnn(-c3ccccc3)c2C)C1.,CO[C@H]1CCCN(C(=O)N[C@@H](C)c2cnn(-c3ccccc3)c2C)C1,benzene_ring
+149280,Remove a amide from the molecule Cc1cc(C)c(C[S@](=O)CC(=O)N(C)c2ccccc2)c(C)c1.,Cc1cc(C)c(C[S@](=O)CC(=O)N(C)c2ccccc2)c(C)c1,amide
+186507,Remove a halo from the molecule Cc1ccc(-n2c([C@H](C)Cl)nc3cc(C)cnc32)c(C)c1.,Cc1ccc(-n2c([C@H](C)Cl)nc3cc(C)cnc32)c(C)c1,halo
+148771,Please remove a benzene_ring from the molecule C[C@H](CN(C(=O)c1ccoc1)c1ccccc1)NC(=O)c1ccoc1.,C[C@H](CN(C(=O)c1ccoc1)c1ccccc1)NC(=O)c1ccoc1,benzene_ring
+12561,Remove a benzene_ring from the molecule Cc1ccc(-n2cnnn2)cc1NC(=O)[C@@H]1C=C[C@@H]([NH3+])C1.,Cc1ccc(-n2cnnn2)cc1NC(=O)[C@@H]1C=C[C@@H]([NH3+])C1,benzene_ring
+119261,Please remove a amide from the molecule CCOC[C@@H]1CCN(C(=O)[C@@H](C)Sc2nnnn2C2CC2)C1.,CCOC[C@@H]1CCN(C(=O)[C@@H](C)Sc2nnnn2C2CC2)C1,amide
+180592,Please remove a amide from the molecule Cc1cc(NC(=O)CSc2nnnn2C2CCCC2)n(-c2ccccc2)n1.,Cc1cc(NC(=O)CSc2nnnn2C2CCCC2)n(-c2ccccc2)n1,amide
+4571,Please remove a benzene_ring from the molecule Cc1ccc(C(=O)[C@H]2CSCCS2)cc1C.,Cc1ccc(C(=O)[C@H]2CSCCS2)cc1C,benzene_ring
+138682,Modify the molecule C[NH2+]Cc1ccccc1NC(=O)C1C(C)(C)C1(C)C by removing a benzene_ring.,C[NH2+]Cc1ccccc1NC(=O)C1C(C)(C)C1(C)C,benzene_ring
+216572,Remove a amide from the molecule O=C(c1ccc([C@H]2CCC[NH2+]2)s1)N1CCC(CN2CCOCC2)CC1.,O=C(c1ccc([C@H]2CCC[NH2+]2)s1)N1CCC(CN2CCOCC2)CC1,amide
+204546,Remove a amide from the molecule CCC(=O)N1CCC[C@H](COc2ccc(C(=O)N3CCCCC3)cc2)C1.,CCC(=O)N1CCC[C@H](COc2ccc(C(=O)N3CCCCC3)cc2)C1,amide
+51575,Modify the molecule CC(C)[C@@H](NC(=O)C(=O)Nc1ccc2c(c1)CCC(=O)N2)c1ccccc1 by removing a amide.,CC(C)[C@@H](NC(=O)C(=O)Nc1ccc2c(c1)CCC(=O)N2)c1ccccc1,amide
+19780,Remove a benzene_ring from the molecule Cc1ccc(S[C@H]2CSc3nc(C)cc(=O)n3[C@@H]2c2ccccc2)cc1.,Cc1ccc(S[C@H]2CSc3nc(C)cc(=O)n3[C@@H]2c2ccccc2)cc1,benzene_ring
+24317,Modify the molecule C[C@@H]1C(=O)CCN(c2ccc(F)cc2F)[C@H]1C by removing a benzene_ring.,C[C@@H]1C(=O)CCN(c2ccc(F)cc2F)[C@H]1C,benzene_ring
+173479,Please remove a amide from the molecule CCN(C(=O)Cc1ccc(F)c(F)c1)[C@@H]1CCC[C@H]1C[NH3+].,CCN(C(=O)Cc1ccc(F)c(F)c1)[C@@H]1CCC[C@H]1C[NH3+],amide
+6403,Modify the molecule O=C(NC[C@@H]1CC[NH+](Cc2cccc(O)c2)C1)c1cc2ccccc2[nH]1 by removing a amide.,O=C(NC[C@@H]1CC[NH+](Cc2cccc(O)c2)C1)c1cc2ccccc2[nH]1,amide
+137534,Please remove a amine from the molecule Cc1c(F)cccc1-c1ccc(CN[C@@H](CO)c2ccco2)o1.,Cc1c(F)cccc1-c1ccc(CN[C@@H](CO)c2ccco2)o1,amine
+71341,Modify the molecule Cc1ccccc1C[NH2+]CC1CC[NH2+]CC1 by removing a benzene_ring.,Cc1ccccc1C[NH2+]CC1CC[NH2+]CC1,benzene_ring
+34245,Remove a amide from the molecule Cc1cccc(C)c1N1CCN(C(=O)c2ccccc2Cl)CC1.,Cc1cccc(C)c1N1CCN(C(=O)c2ccccc2Cl)CC1,amide
+18884,Modify the molecule COc1ccc(O)c([C@H](C)NC(=O)Nc2cccc(C)c2Cl)c1 by removing a hydroxyl.,COc1ccc(O)c([C@H](C)NC(=O)Nc2cccc(C)c2Cl)c1,hydroxyl
+8154,Please remove a hydroxyl from the molecule COc1cc(CN2CCC([NH+]3CCC[C@@H]3C)CC2)cc([N+](=O)[O-])c1O.,COc1cc(CN2CCC([NH+]3CCC[C@@H]3C)CC2)cc([N+](=O)[O-])c1O,hydroxyl
+19498,Remove a amide from the molecule Cc1nnc2ccc(C(=O)N3CCCCC[C@H]3c3cccn3C)cn12.,Cc1nnc2ccc(C(=O)N3CCCCC[C@H]3c3cccn3C)cn12,amide
+64782,Modify the molecule OCC[NH+]1CCN(C(=S)NCc2ccco2)CC1 by removing a amine.,OCC[NH+]1CCN(C(=S)NCc2ccco2)CC1,amine
+88735,Please remove a nitrile from the molecule C[C@H]1CO[C@@H](c2ccccc2)[C@H](C)N1Cc1cnc2ccc(C#N)cn12.,C[C@H]1CO[C@@H](c2ccccc2)[C@H](C)N1Cc1cnc2ccc(C#N)cn12,nitrile
+128684,Modify the molecule C[C@H]1CCCC[C@H]1NC(=O)C(=O)Nc1ccc(Cl)c(C(=O)NC2CC2)c1 by removing a halo.,C[C@H]1CCCC[C@H]1NC(=O)C(=O)Nc1ccc(Cl)c(C(=O)NC2CC2)c1,halo
+152276,Modify the molecule C[C@@H](C(=O)NCc1ccc(F)cc1)C1CCN(S(=O)(=O)c2ccc(Cl)s2)CC1 by removing a benzene_ring.,C[C@@H](C(=O)NCc1ccc(F)cc1)C1CCN(S(=O)(=O)c2ccc(Cl)s2)CC1,benzene_ring
+15721,Please remove a halo from the molecule COc1ccc(S(=O)(=O)NC[C@@H]2CCN(c3ccc(F)c(F)c3)C2)cc1C.,COc1ccc(S(=O)(=O)NC[C@@H]2CCN(c3ccc(F)c(F)c3)C2)cc1C,halo
+216083,Modify the molecule Cc1nnc2ccc(Nc3ccc4oc(=O)n(CC[NH+](C)C)c4c3)nn12 by removing a amine.,Cc1nnc2ccc(Nc3ccc4oc(=O)n(CC[NH+](C)C)c4c3)nn12,amine
+52058,Please remove a benzene_ring from the molecule Nc1ccc(CCNC(=O)Cc2ccc(F)c(F)c2)cc1.,Nc1ccc(CCNC(=O)Cc2ccc(F)c(F)c2)cc1,benzene_ring
+220510,Remove a amide from the molecule COc1ccccc1C[NH+]1CCC(Oc2ccc(C(=O)NC3CCCC3)cc2Cl)CC1.,COc1ccccc1C[NH+]1CCC(Oc2ccc(C(=O)NC3CCCC3)cc2Cl)CC1,amide
+186841,Modify the molecule CCCC(=O)N1CCC[C@@H](C(=O)N[C@H]2C[C@H]2CCC)C1 by removing a amide.,CCCC(=O)N1CCC[C@@H](C(=O)N[C@H]2C[C@H]2CCC)C1,amide
+171856,Remove a amide from the molecule CCCOc1ccc(NC(=O)CNC(C)=O)cc1Cl.,CCCOc1ccc(NC(=O)CNC(C)=O)cc1Cl,amide
+38876,Please remove a benzene_ring from the molecule Cc1[nH]c(=O)c(C(=O)OC[C@@H]2C[C@H]2C)cc1-c1ccccc1.,Cc1[nH]c(=O)c(C(=O)OC[C@@H]2C[C@H]2C)cc1-c1ccccc1,benzene_ring
+119552,Modify the molecule O=C(NCc1ccc(Cl)cc1)c1ccc(CNc2c(O)c(=O)c2=[N+]2CCCCC2)cc1 by removing a amine.,O=C(NCc1ccc(Cl)cc1)c1ccc(CNc2c(O)c(=O)c2=[N+]2CCCCC2)cc1,amine
+210836,Please remove a amide from the molecule CC(C)N(Cc1cccnc1)C(=O)CN1C(=O)[C@@H]2CCCC[C@H]2C1=O.,CC(C)N(Cc1cccnc1)C(=O)CN1C(=O)[C@@H]2CCCC[C@H]2C1=O,amide
+239779,Modify the molecule O=C([O-])c1cncc(Nc2ccc(Cl)cc2C(F)(F)F)n1 by removing a halo.,O=C([O-])c1cncc(Nc2ccc(Cl)cc2C(F)(F)F)n1,halo
+181976,Modify the molecule CC[C@H]1CC[NH+](Cc2cc(Cl)ccc2O)C1 by removing a halo.,CC[C@H]1CC[NH+](Cc2cc(Cl)ccc2O)C1,halo
+138514,Remove a amine from the molecule CNC(=S)Nc1n[nH]c(SC)n1.,CNC(=S)Nc1n[nH]c(SC)n1,amine
+248091,Please remove a amide from the molecule O=C(C1=C[C@H]2N=CC=C2C=C1)N(Cc1cccnc1)CC1CC[NH+](C2CCCC2)CC1.,O=C(C1=C[C@H]2N=CC=C2C=C1)N(Cc1cccnc1)CC1CC[NH+](C2CCCC2)CC1,amide
+200254,Remove a halo from the molecule CC[C@H]1CCC(=O)[C@H](Cc2cc(Cl)ccc2[N+](=O)[O-])C1.,CC[C@H]1CCC(=O)[C@H](Cc2cc(Cl)ccc2[N+](=O)[O-])C1,halo
+15183,Modify the molecule CCOC(=O)C1=C(N)Oc2cc(C)n(CC[NH+](C)C)c(=O)c2[C@H]1c1ccc(Cl)cc1 by removing a amine.,CCOC(=O)C1=C(N)Oc2cc(C)n(CC[NH+](C)C)c(=O)c2[C@H]1c1ccc(Cl)cc1,amine
+67270,Please remove a benzene_ring from the molecule Cc1ccc([S@@](=O)[C@H]2CCC(C)(C)[C@@H]2[NH3+])cc1C.,Cc1ccc([S@@](=O)[C@H]2CCC(C)(C)[C@@H]2[NH3+])cc1C,benzene_ring
+190042,Remove a benzene_ring from the molecule O=C(NC(=S)N1CCOCC1)c1ccccc1C(=O)OCC(F)(F)F.,O=C(NC(=S)N1CCOCC1)c1ccccc1C(=O)OCC(F)(F)F,benzene_ring
+135199,Please remove a amide from the molecule Cn1cccc(NC(=O)C(=O)N2CC[C@@H](Cc3ccccc3)C2)c1=O.,Cn1cccc(NC(=O)C(=O)N2CC[C@@H](Cc3ccccc3)C2)c1=O,amide
+21721,Please remove a amide from the molecule Cc1nc(CN(C)C(=O)[C@@H]2CC[NH2+][C@H]2C)n[nH]1.,Cc1nc(CN(C)C(=O)[C@@H]2CC[NH2+][C@H]2C)n[nH]1,amide
+89615,Remove a benzene_ring from the molecule CC(=O)c1ccc(S(=O)(=O)N(C)Cc2ccc([C@H]3C[C@@H]3C)o2)cc1.,CC(=O)c1ccc(S(=O)(=O)N(C)Cc2ccc([C@H]3C[C@@H]3C)o2)cc1,benzene_ring
+145981,Modify the molecule Cc1cc(C)c2c3ccccc3n(CCNC(=O)c3cccc4cccnc34)c2n1 by removing a amide.,Cc1cc(C)c2c3ccccc3n(CCNC(=O)c3cccc4cccnc34)c2n1,amide
+239626,Remove a amide from the molecule COc1cc2c(cc1OC)[C@@]1(Cc3ccc(Cl)cc3)[C@@H]3CC=CC[C@@H]3C(=O)N1CC2.,COc1cc2c(cc1OC)[C@@]1(Cc3ccc(Cl)cc3)[C@@H]3CC=CC[C@@H]3C(=O)N1CC2,amide
+177278,Remove a amide from the molecule C=CCN1C[C@H](C(=O)Cl)CC1=O.,C=CCN1C[C@H](C(=O)Cl)CC1=O,amide
+245779,Remove a benzene_ring from the molecule Cc1ccc(-c2ccc(=O)n(Cc3noc(C(=O)N4CCCC4)n3)n2)cc1C.,Cc1ccc(-c2ccc(=O)n(Cc3noc(C(=O)N4CCCC4)n3)n2)cc1C,benzene_ring
+160211,Modify the molecule NS(=O)(=O)CCN(CCO)Cc1cc(Br)ccc1F by removing a halo.,NS(=O)(=O)CCN(CCO)Cc1cc(Br)ccc1F,halo
+133449,Modify the molecule COc1ccc([C@@H](C)[C@H](C)[NH2+]C2CCN(S(=O)(=O)C3CC3)CC2)cc1 by removing a benzene_ring.,COc1ccc([C@@H](C)[C@H](C)[NH2+]C2CCN(S(=O)(=O)C3CC3)CC2)cc1,benzene_ring
+76853,Remove a benzene_ring from the molecule c1ccc(-c2cc(N3CCC[C@@H](Cn4cc[nH+]c4)C3)n3nccc3n2)cc1.,c1ccc(-c2cc(N3CCC[C@@H](Cn4cc[nH+]c4)C3)n3nccc3n2)cc1,benzene_ring
+64542,Remove a amide from the molecule C[C@@H](NC(=O)CN1CCCC1=O)c1cccc2ccccc12.,C[C@@H](NC(=O)CN1CCCC1=O)c1cccc2ccccc12,amide
+49854,Modify the molecule O=C(Nc1ccc(OC(F)F)cc1)[C@@H]1CCCCN1S(=O)(=O)c1ccccc1 by removing a amide.,O=C(Nc1ccc(OC(F)F)cc1)[C@@H]1CCCCN1S(=O)(=O)c1ccccc1,amide
+72889,Remove a amine from the molecule Cc1nnc2ccc(N[C@H](C)C(=O)N3CCOCC3)nn12.,Cc1nnc2ccc(N[C@H](C)C(=O)N3CCOCC3)nn12,amine
+217840,Please remove a amine from the molecule O=[N+]([O-])c1cccnc1N[C@H]1c2ccccc2C[C@H]1O.,O=[N+]([O-])c1cccnc1N[C@H]1c2ccccc2C[C@H]1O,amine
+154132,Please remove a halo from the molecule Cc1nn(C(=O)OC(C)(C)C)c(C)c1Br.,Cc1nn(C(=O)OC(C)(C)C)c(C)c1Br,halo
+109418,Modify the molecule C[C@H]1C[NH+]2CCC[C@@H]2CN1c1cc(Cl)ccc1C(=O)[O-] by removing a benzene_ring.,C[C@H]1C[NH+]2CCC[C@@H]2CN1c1cc(Cl)ccc1C(=O)[O-],benzene_ring
+100088,Remove a amide from the molecule C=CC(=O)N[C@@H](C)c1nc2ccccc2n1C.,C=CC(=O)N[C@@H](C)c1nc2ccccc2n1C,amide
+186730,Modify the molecule CCN(C[C@@H](C)C#N)C(=O)Nc1c(C(C)C)cccc1C(C)C by removing a benzene_ring.,CCN(C[C@@H](C)C#N)C(=O)Nc1c(C(C)C)cccc1C(C)C,benzene_ring
+125743,Remove a amide from the molecule O=C(CC1(O)CCCC1)NCc1cn2cc(Br)ccc2n1.,O=C(CC1(O)CCCC1)NCc1cn2cc(Br)ccc2n1,amide
+163840,Please remove a nitrile from the molecule N#C[C@H]1C(=O)NC(=S)[C@@H](C(N)=O)C12CCCCC2.,N#C[C@H]1C(=O)NC(=S)[C@@H](C(N)=O)C12CCCCC2,nitrile
+97706,Modify the molecule COC(=O)c1cc2n(n1)CCN(C(=O)c1cc(-c3ccccc3O)n[nH]1)C2 by removing a amide.,COC(=O)c1cc2n(n1)CCN(C(=O)c1cc(-c3ccccc3O)n[nH]1)C2,amide
+46258,Modify the molecule C[C@@H]1C[C@H]1N1C[C@H](NC(=O)Cc2cccc(O)c2)CC1=O by removing a amide.,C[C@@H]1C[C@H]1N1C[C@H](NC(=O)Cc2cccc(O)c2)CC1=O,amide
+35311,Please remove a benzene_ring from the molecule CS(=O)(=O)c1ccccc1C(=O)Nc1nc(-c2ccc([N+](=O)[O-])cc2)cs1.,CS(=O)(=O)c1ccccc1C(=O)Nc1nc(-c2ccc([N+](=O)[O-])cc2)cs1,benzene_ring
+175858,Please remove a benzene_ring from the molecule CC[C@H]1CCN(C(=O)Nc2cccc(CS(=O)(=O)N[C@H](C)CC)c2)C1.,CC[C@H]1CCN(C(=O)Nc2cccc(CS(=O)(=O)N[C@H](C)CC)c2)C1,benzene_ring
+206081,Please remove a halo from the molecule CC[NH+](CCC(=O)Nc1ccc(F)cc1N)C(C)C.,CC[NH+](CCC(=O)Nc1ccc(F)cc1N)C(C)C,halo
+113735,Modify the molecule CCc1cccc(NC(=O)c2cc(C)c(C#CCO)s2)c1 by removing a amide.,CCc1cccc(NC(=O)c2cc(C)c(C#CCO)s2)c1,amide
+54729,Remove a amide from the molecule N/C(=N/OCC(=O)N1CCCCCCC1)c1cnccn1.,N/C(=N/OCC(=O)N1CCCCCCC1)c1cnccn1,amide
+73946,Remove a hydroxyl from the molecule C/C(=N\O)[C@H]1C[C@H]2C=C(C#N)[C@@H]1[NH+](Cc1ccccc1)C2.,C/C(=N\O)[C@H]1C[C@H]2C=C(C#N)[C@@H]1[NH+](Cc1ccccc1)C2,hydroxyl
+134512,Remove a amide from the molecule C[C@@H]1CCC[C@H]1[NH2+]CCNC(=O)CC1CCCCC1.,C[C@@H]1CCC[C@H]1[NH2+]CCNC(=O)CC1CCCCC1,amide
+64649,Remove a benzene_ring from the molecule COc1ccc(-n2cnc3c2N=C(O)C[C@H]3c2ccc(F)cc2)cc1.,COc1ccc(-n2cnc3c2N=C(O)C[C@H]3c2ccc(F)cc2)cc1,benzene_ring
+40047,Modify the molecule COc1ccc(NC(=S)NC(=O)C2CCC2)cc1 by removing a amine.,COc1ccc(NC(=S)NC(=O)C2CCC2)cc1,amine
+149344,Please remove a amide from the molecule CCOC(=O)[C@H]1C[NH2+]C[C@]12COc1ccccc1C(=O)N2.,CCOC(=O)[C@H]1C[NH2+]C[C@]12COc1ccccc1C(=O)N2,amide
+177583,Modify the molecule Cc1occc1C(=O)NCC(=O)NC[C@@H](C)c1nc(-c2ccccc2)no1 by removing a benzene_ring.,Cc1occc1C(=O)NCC(=O)NC[C@@H](C)c1nc(-c2ccccc2)no1,benzene_ring
+238478,Please remove a amide from the molecule CC(C)c1ccc2cc(C(=O)N(C)Cc3ccc(Br)o3)[nH]c2c1.,CC(C)c1ccc2cc(C(=O)N(C)Cc3ccc(Br)o3)[nH]c2c1,amide
+175797,Please remove a benzene_ring from the molecule Cc1ccc(COc2ccc(-c3nnco3)cc2)cc1.,Cc1ccc(COc2ccc(-c3nnco3)cc2)cc1,benzene_ring
+168043,Modify the molecule COc1cc(C(C)=O)ccc1OCC(=O)NC1C[C@@H]2CCC[C@H](C1)[NH+]2C by removing a benzene_ring.,COc1cc(C(C)=O)ccc1OCC(=O)NC1C[C@@H]2CCC[C@H](C1)[NH+]2C,benzene_ring
+79043,Modify the molecule CC(C)C[NH+]1CCN(Cn2nnn(-c3ccc(Cl)cc3)c2=S)CC1 by removing a benzene_ring.,CC(C)C[NH+]1CCN(Cn2nnn(-c3ccc(Cl)cc3)c2=S)CC1,benzene_ring
+170692,Modify the molecule C[NH2+]Cc1ccccc1O[C@@H](C)C(=O)NC(N)=O by removing a amide.,C[NH2+]Cc1ccccc1O[C@@H](C)C(=O)NC(N)=O,amide
+61582,Please remove a nitro from the molecule CCNC(=O)C(=O)N/N=C\c1cc([N+](=O)[O-])ccc1[O-].,CCNC(=O)C(=O)N/N=C\c1cc([N+](=O)[O-])ccc1[O-],nitro
+103178,Please remove a benzene_ring from the molecule CCCc1ccc(OCc2cnc(N)s2)cc1.,CCCc1ccc(OCc2cnc(N)s2)cc1,benzene_ring
+107466,Modify the molecule COc1ccnc(NC(=O)[C@@H](C)c2ccc(Br)s2)c1 by removing a halo.,COc1ccnc(NC(=O)[C@@H](C)c2ccc(Br)s2)c1,halo
+174546,Remove a halo from the molecule [NH2+]=c1oc2ccc(Br)cc2cc1C(=O)NCc1cccnc1.,[NH2+]=c1oc2ccc(Br)cc2cc1C(=O)NCc1cccnc1,halo
+223533,Remove a amide from the molecule C[C@H](NC(=O)CCn1ccccc1=O)C(=O)[O-].,C[C@H](NC(=O)CCn1ccccc1=O)C(=O)[O-],amide
+201022,Modify the molecule O[C@H]1CCCC[C@H]1Sc1nnc(-c2ccc(Cl)s2)o1 by removing a halo.,O[C@H]1CCCC[C@H]1Sc1nnc(-c2ccc(Cl)s2)o1,halo
+26235,Please remove a amide from the molecule CC[NH+](C)CC(=O)NC[C@H]1CN(CC(C)C)CCO1.,CC[NH+](C)CC(=O)NC[C@H]1CN(CC(C)C)CCO1,amide
+22265,Remove a amide from the molecule O=C([O-])COCC(=O)Nc1ccc2c(c1)CCCC2.,O=C([O-])COCC(=O)Nc1ccc2c(c1)CCCC2,amide
+36182,Modify the molecule O=C(Nc1ccnn1Cc1cccc2ccccc12)c1cccnc1Cl by removing a amide.,O=C(Nc1ccnn1Cc1cccc2ccccc12)c1cccnc1Cl,amide
+46096,Remove a amide from the molecule CCc1cc(=O)n2c(n1)SC[C@@H]2CC(=O)Nc1ccccc1OC.,CCc1cc(=O)n2c(n1)SC[C@@H]2CC(=O)Nc1ccccc1OC,amide
+70190,Please remove a amide from the molecule CCC[C@@H](C)NC(=O)[C@@H]1CCCN(C(=O)Nc2ccc(C(=O)NC)cc2)C1.,CCC[C@@H](C)NC(=O)[C@@H]1CCCN(C(=O)Nc2ccc(C(=O)NC)cc2)C1,amide
+162466,Please remove a benzene_ring from the molecule CNc1ccc(C(=O)[O-])cc1C(=O)[O-].,CNc1ccc(C(=O)[O-])cc1C(=O)[O-],benzene_ring
+191171,Remove a halo from the molecule C/C(=C\c1ccc(F)cc1)C(=O)OC[C@H]1CCCO1.,C/C(=C\c1ccc(F)cc1)C(=O)OC[C@H]1CCCO1,halo
+131543,Please remove a benzene_ring from the molecule CN(C)c1ccc(C[C@H](C(N)=S)c2nc3ccccc3[nH]2)cc1.,CN(C)c1ccc(C[C@H](C(N)=S)c2nc3ccccc3[nH]2)cc1,benzene_ring
+141084,Modify the molecule CCn1c(=O)n(CC(=O)N2CCn3c(C)nnc3C2)c2ccccc21 by removing a amide.,CCn1c(=O)n(CC(=O)N2CCn3c(C)nnc3C2)c2ccccc21,amide
+75068,Please remove a benzene_ring from the molecule CC(=O)N1CCc2ccccc2[C@H]1CC(=O)O[C@@H](C)c1cccc(F)c1.,CC(=O)N1CCc2ccccc2[C@H]1CC(=O)O[C@@H](C)c1cccc(F)c1,benzene_ring
+39831,Remove a amide from the molecule O=C(Nc1cc(F)ccc1Cl)[C@@H](O)c1ccccc1.,O=C(Nc1cc(F)ccc1Cl)[C@@H](O)c1ccccc1,amide
+97439,Modify the molecule CN(C)C(=O)c1cccc(S(=O)(=O)N2CCCc3cccc(F)c32)c1 by removing a benzene_ring.,CN(C)C(=O)c1cccc(S(=O)(=O)N2CCCc3cccc(F)c32)c1,benzene_ring
+203090,Please remove a amide from the molecule Cc1ccc([C@H]2[C@@H](C(=O)N[C@@H](C)c3nc4ccccc4o3)CCC(=O)N2C)cc1.,Cc1ccc([C@H]2[C@@H](C(=O)N[C@@H](C)c3nc4ccccc4o3)CCC(=O)N2C)cc1,amide
+232374,Please remove a amide from the molecule CCOc1ccc(-c2nc(C(=O)N3CCNC(=O)[C@@H]3CC)cs2)cc1.,CCOc1ccc(-c2nc(C(=O)N3CCNC(=O)[C@@H]3CC)cs2)cc1,amide
+81903,Please remove a amide from the molecule C=CCN(C(=O)[C@@H]1CS[C@@]2(C)CCC(=O)N12)c1nc2c(s1)CCCC2.,C=CCN(C(=O)[C@@H]1CS[C@@]2(C)CCC(=O)N12)c1nc2c(s1)CCCC2,amide
+89947,Remove a amine from the molecule CO[C@@H](C)/C(N)=N/OCCOC1CCCCCC1.,CO[C@@H](C)/C(N)=N/OCCOC1CCCCCC1,amine
+226041,Please remove a nitrile from the molecule C[C@@H](CC#N)N(C)C(=O)Nc1ccc(Cl)cc1F.,C[C@@H](CC#N)N(C)C(=O)Nc1ccc(Cl)cc1F,nitrile
+211269,Remove a halo from the molecule O=C(NCC[NH+]1CCC(CO)CC1)Nc1ccc(C(F)(F)F)cc1.,O=C(NCC[NH+]1CCC(CO)CC1)Nc1ccc(C(F)(F)F)cc1,halo
+118419,Remove a halo from the molecule Cc1cc(N(CCC(F)(F)F)CC2CC2)nc(-c2ccccn2)n1.,Cc1cc(N(CCC(F)(F)F)CC2CC2)nc(-c2ccccn2)n1,halo
+97248,Please remove a benzene_ring from the molecule NC(=O)N1CCC[C@H](C(=O)Nc2cccc(-c3nc4ccccc4s3)c2)C1.,NC(=O)N1CCC[C@H](C(=O)Nc2cccc(-c3nc4ccccc4s3)c2)C1,benzene_ring
+115897,Remove a amide from the molecule CC(=O)c1cccc(OCC2=C[C@@H](C(=O)NCc3ccco3)N=N2)c1.,CC(=O)c1cccc(OCC2=C[C@@H](C(=O)NCc3ccco3)N=N2)c1,amide
+170866,Please remove a benzene_ring from the molecule CCCNc1ncnc(Nc2ccc(I)cc2)c1[N+](=O)[O-].,CCCNc1ncnc(Nc2ccc(I)cc2)c1[N+](=O)[O-],benzene_ring
+88810,Please remove a amide from the molecule CCc1ccc([C@H](COC)NC(=O)C(=O)Nc2ccc3ncccc3c2)o1.,CCc1ccc([C@H](COC)NC(=O)C(=O)Nc2ccc3ncccc3c2)o1,amide
+158687,Remove a nitrile from the molecule C=C(C)COc1nc(C)c2c(c1C#N)CC(C)(C)OC2.,C=C(C)COc1nc(C)c2c(c1C#N)CC(C)(C)OC2,nitrile
+246241,Remove a hydroxyl from the molecule O=C([O-])C[C@](O)(c1ccco1)C(F)(F)F.,O=C([O-])C[C@](O)(c1ccco1)C(F)(F)F,hydroxyl
+35330,Remove a amine from the molecule CCOc1ccc(S(=O)(=O)NCc2ccco2)cc1C(C)C.,CCOc1ccc(S(=O)(=O)NCc2ccco2)cc1C(C)C,amine
+18900,Please remove a amine from the molecule CCn1nc(C(=O)N2CCCC2)c2c1CC[C@@H](NCc1nc(-c3ccccc3)cs1)C2.,CCn1nc(C(=O)N2CCCC2)c2c1CC[C@@H](NCc1nc(-c3ccccc3)cs1)C2,amine
+6101,Remove a benzene_ring from the molecule CC[NH2+][C@]1(C(=O)[O-])CCC[C@@H]1CCSc1ccc(C)cc1.,CC[NH2+][C@]1(C(=O)[O-])CCC[C@@H]1CCSc1ccc(C)cc1,benzene_ring
+156633,Modify the molecule CCc1noc(C)c1C(=O)Nc1ccc(Cl)cc1C(F)(F)F by removing a halo.,CCc1noc(C)c1C(=O)Nc1ccc(Cl)cc1C(F)(F)F,halo
+55822,Modify the molecule CC1(C)CN(C(=O)Cc2ccc(C(F)(F)F)cc2)CC[S@]1=O by removing a halo.,CC1(C)CN(C(=O)Cc2ccc(C(F)(F)F)cc2)CC[S@]1=O,halo
+123318,Please remove a amine from the molecule COC1CCN(c2ccc(C(F)(F)F)cc2C(N)=[NH2+])CC1.,COC1CCN(c2ccc(C(F)(F)F)cc2C(N)=[NH2+])CC1,amine
+208230,Modify the molecule Cc1nn(C(C)C)c(C)c1S(=O)(=O)[N-]c1cccc(C(=O)[O-])c1C by removing a benzene_ring.,Cc1nn(C(C)C)c(C)c1S(=O)(=O)[N-]c1cccc(C(=O)[O-])c1C,benzene_ring
+228388,Please remove a halo from the molecule C[C@H](C(=O)N1CCCC1)N1CCN(c2ccc(Cl)c(C#N)n2)CC1.,C[C@H](C(=O)N1CCCC1)N1CCN(c2ccc(Cl)c(C#N)n2)CC1,halo
+86092,Please remove a benzene_ring from the molecule CO/N=C/c1ccc(C(=O)N(C)[C@H](C)c2ccc([S@](C)=O)cc2)cc1.,CO/N=C/c1ccc(C(=O)N(C)[C@H](C)c2ccc([S@](C)=O)cc2)cc1,benzene_ring
+136241,Modify the molecule Cc1cc(CC(=O)NCCOc2c(C)cccc2C)no1 by removing a amide.,Cc1cc(CC(=O)NCCOc2c(C)cccc2C)no1,amide
+140901,Modify the molecule N#Cc1c(-c2ccc(F)cc2)cc(-c2ccccc2)nc1N by removing a nitrile.,N#Cc1c(-c2ccc(F)cc2)cc(-c2ccccc2)nc1N,nitrile
+116479,Modify the molecule CCO[C@@H]1CCCN(C(=O)c2nc(C(C)(C)C)n[nH]2)C1 by removing a amide.,CCO[C@@H]1CCCN(C(=O)c2nc(C(C)(C)C)n[nH]2)C1,amide
+187541,Modify the molecule Cc1ccccc1-c1cnc(CNN2CCCCC2)s1 by removing a benzene_ring.,Cc1ccccc1-c1cnc(CNN2CCCCC2)s1,benzene_ring
+132929,Modify the molecule Cc1c(Cl)cccc1-n1c(S[C@@H](C)C(N)=O)nc2ccccc2c1=O by removing a halo.,Cc1c(Cl)cccc1-n1c(S[C@@H](C)C(N)=O)nc2ccccc2c1=O,halo
+44500,Modify the molecule CC[NH2+][C@@H](CCC(F)(F)F)[C@@H]1C[NH+]2CCN1CC2 by removing a halo.,CC[NH2+][C@@H](CCC(F)(F)F)[C@@H]1C[NH+]2CCN1CC2,halo
+191921,Modify the molecule COc1ccccc1[C@@H](O)[C@H](C)C#N by removing a benzene_ring.,COc1ccccc1[C@@H](O)[C@H](C)C#N,benzene_ring
+197986,Modify the molecule Cc1cc(F)cc([C@H]([NH3+])Cc2cccc(C(F)(F)F)c2)c1 by removing a benzene_ring.,Cc1cc(F)cc([C@H]([NH3+])Cc2cccc(C(F)(F)F)c2)c1,benzene_ring
+86334,Modify the molecule CCOc1ccc(Cl)cc1/C=N/N1C(=O)[C@@H]2C3c4ccccc4C(c4ccccc43)[C@H]2C1=O by removing a benzene_ring.,CCOc1ccc(Cl)cc1/C=N/N1C(=O)[C@@H]2C3c4ccccc4C(c4ccccc43)[C@H]2C1=O,benzene_ring
+2168,Modify the molecule CCn1cc[nH+]c1[C@@H]1CCCN(C(=O)CSCC[NH+]2CCCC2)C1 by removing a amide.,CCn1cc[nH+]c1[C@@H]1CCCN(C(=O)CSCC[NH+]2CCCC2)C1,amide
+235393,Please remove a amine from the molecule CC[NH+]1CCC[C@H]1CNC(=O)c1sc2ncnc(NCc3ccc4c(c3)OCO4)c2c1C.,CC[NH+]1CCC[C@H]1CNC(=O)c1sc2ncnc(NCc3ccc4c(c3)OCO4)c2c1C,amine
+244950,Please remove a amide from the molecule C[C@H](NC(=O)c1cccs1)C(=O)N1CCc2c(sc(N)c2C#N)C1.,C[C@H](NC(=O)c1cccs1)C(=O)N1CCc2c(sc(N)c2C#N)C1,amide
+125572,Modify the molecule O[C@]12CCCC[C@H]1[C@@H](Cc1cccnc1Cl)[NH2+]CC2 by removing a hydroxyl.,O[C@]12CCCC[C@H]1[C@@H](Cc1cccnc1Cl)[NH2+]CC2,hydroxyl
+220551,Remove a amide from the molecule CCc1ccccc1OCC(=O)NCc1cscn1.,CCc1ccccc1OCC(=O)NCc1cscn1,amide
+129812,Please remove a amide from the molecule CCCN(C(=O)Cn1ncc2c(=O)oc3ccccc3c21)c1ccc(OCC)cc1.,CCCN(C(=O)Cn1ncc2c(=O)oc3ccccc3c21)c1ccc(OCC)cc1,amide
+52166,Modify the molecule COC(=O)c1ccc(NC(=O)Cn2ncc3c([nH]c4ccccc43)c2=O)cc1 by removing a benzene_ring.,COC(=O)c1ccc(NC(=O)Cn2ncc3c([nH]c4ccccc43)c2=O)cc1,benzene_ring
+32235,Please remove a benzene_ring from the molecule CN(C)C(=O)Oc1ccc(C2CCCCC2)cc1.,CN(C)C(=O)Oc1ccc(C2CCCCC2)cc1,benzene_ring
+11662,Modify the molecule COc1ccc(O[C@H](C)C(=O)Nc2ccnn2Cc2ccc(C)cc2)cc1 by removing a benzene_ring.,COc1ccc(O[C@H](C)C(=O)Nc2ccnn2Cc2ccc(C)cc2)cc1,benzene_ring
+235827,Modify the molecule CCN(CC)C(=O)Cn1c(CNC(=O)c2ccccc2F)nc2ccccc21 by removing a halo.,CCN(CC)C(=O)Cn1c(CNC(=O)c2ccccc2F)nc2ccccc21,halo
+15997,Modify the molecule COC(=O)CNC(=O)c1ccc(OCc2ccccc2C#N)cc1 by removing a amide.,COC(=O)CNC(=O)c1ccc(OCc2ccccc2C#N)cc1,amide
+246361,Please remove a hydroxyl from the molecule Oc1ccc(O)c(C[NH2+]C2CCCCC2)c1.,Oc1ccc(O)c(C[NH2+]C2CCCCC2)c1,hydroxyl
+174155,Modify the molecule COc1ccc(Oc2cc(CNC(=O)Nc3ccccc3)ccn2)cc1 by removing a benzene_ring.,COc1ccc(Oc2cc(CNC(=O)Nc3ccccc3)ccn2)cc1,benzene_ring
+67636,Please remove a amine from the molecule O=S(=O)(NCC[C@H]1C[C@@H]2CC[C@H]1C2)N1CCOCC1.,O=S(=O)(NCC[C@H]1C[C@@H]2CC[C@H]1C2)N1CCOCC1,amine
+16359,Remove a amide from the molecule O=C(Nc1cc([N+](=O)[O-])ccc1F)[C@@H]1CCCN1C(=O)OCC(F)(F)F.,O=C(Nc1cc([N+](=O)[O-])ccc1F)[C@@H]1CCCN1C(=O)OCC(F)(F)F,amide
+68665,Please remove a amide from the molecule Cc1c(C(=O)N[C@@H]2CC[C@@H]([NH+](C)C)C2)cnc2c1c(=O)n(C)c(=O)n2C.,Cc1c(C(=O)N[C@@H]2CC[C@@H]([NH+](C)C)C2)cnc2c1c(=O)n(C)c(=O)n2C,amide
+70275,Modify the molecule CC(C)[C@H](C)NC(=O)CSc1nnc(C2CC2)n1C1CC1 by removing a amide.,CC(C)[C@H](C)NC(=O)CSc1nnc(C2CC2)n1C1CC1,amide
+25414,Remove a amine from the molecule COc1cc([C@@H]2C3=C(C[C@H](c4ccccc4)CC3=O)Nc3ccc4ncccc4c32)ccc1OC(C)=O.,COc1cc([C@@H]2C3=C(C[C@H](c4ccccc4)CC3=O)Nc3ccc4ncccc4c32)ccc1OC(C)=O,amine
+32958,Modify the molecule Cc1nc(CC(=O)N2CCC3(CC2)CC(=O)N(C[C@H]2CCCO2)C3)cs1 by removing a amide.,Cc1nc(CC(=O)N2CCC3(CC2)CC(=O)N(C[C@H]2CCCO2)C3)cs1,amide
+214024,Please remove a benzene_ring from the molecule Cc1cccc(C2=CCN(C(=O)[C@H]3CC(=O)Nc4ccccc43)CC2)c1.,Cc1cccc(C2=CCN(C(=O)[C@H]3CC(=O)Nc4ccccc43)CC2)c1,benzene_ring
+191280,Please remove a benzene_ring from the molecule C=CC1CC[NH+](Cc2ccccc2OCCOC)CC1.,C=CC1CC[NH+](Cc2ccccc2OCCOC)CC1,benzene_ring
+36372,Remove a amine from the molecule C[C@H]1[C@@H](C(=O)[O-])CC[NH+]1CC(=O)NNc1ccccn1.,C[C@H]1[C@@H](C(=O)[O-])CC[NH+]1CC(=O)NNc1ccccn1,amine
+150302,Modify the molecule Oc1cccc(CC2(c3ccccc3)C[NH2+]C2)c1 by removing a hydroxyl.,Oc1cccc(CC2(c3ccccc3)C[NH2+]C2)c1,hydroxyl
+40919,Please remove a amine from the molecule CCNC(=O)CN(CC)c1ncncc1N.,CCNC(=O)CN(CC)c1ncncc1N,amine
+203128,Please remove a amine from the molecule C[C@@H](C(N)=S)N(C)C(=O)[C@H]1CCO[C@@H]1C.,C[C@@H](C(N)=S)N(C)C(=O)[C@H]1CCO[C@@H]1C,amine
+225077,Modify the molecule Cc1nn(C)c(C)c1C[NH2+]CC(=O)NC1CC1 by removing a amide.,Cc1nn(C)c(C)c1C[NH2+]CC(=O)NC1CC1,amide
+229325,Please remove a halo from the molecule CCCn1cc[nH+]c1Cc1cc(Cl)ncn1.,CCCn1cc[nH+]c1Cc1cc(Cl)ncn1,halo
+149555,Remove a halo from the molecule O=C(Cn1ccc2ccc(F)cc21)N1CCN(CCc2ccccn2)CC1.,O=C(Cn1ccc2ccc(F)cc21)N1CCN(CCc2ccccn2)CC1,halo
+48408,Remove a amine from the molecule C[NH+]1CC[C@H](NCc2ccccc2F)[C@H](c2ccccc2)C1.,C[NH+]1CC[C@H](NCc2ccccc2F)[C@H](c2ccccc2)C1,amine
+77273,Remove a amide from the molecule CN(C(=O)c1cc(=O)[nH]c2ccc(S(=O)(=O)[N-]c3ccc(F)cc3)cc12)[C@H]1CCS(=O)(=O)C1.,CN(C(=O)c1cc(=O)[nH]c2ccc(S(=O)(=O)[N-]c3ccc(F)cc3)cc12)[C@H]1CCS(=O)(=O)C1,amide
+189406,Remove a halo from the molecule C[C@H](Oc1ccc(Br)cc1)C(=O)N[C@H](C)c1ccc(-n2ccnc2)cc1.,C[C@H](Oc1ccc(Br)cc1)C(=O)N[C@H](C)c1ccc(-n2ccnc2)cc1,halo
+116799,Please remove a benzene_ring from the molecule C[C@H]1CCC[C@@H](OC(=O)c2cccc(C(F)(F)F)c2F)C1.,C[C@H]1CCC[C@@H](OC(=O)c2cccc(C(F)(F)F)c2F)C1,benzene_ring
+79534,Modify the molecule COc1ccc(C)cc1[C@@H](C)NC(=O)N1CC[NH+](CC(C)C)CC1 by removing a benzene_ring.,COc1ccc(C)cc1[C@@H](C)NC(=O)N1CC[NH+](CC(C)C)CC1,benzene_ring
+162172,Modify the molecule O=C([C@H]1CC=CCC1)N1CCC([C@@]2(c3cccnc3)NC(=O)N(CCc3cccs3)C2=O)CC1 by removing a amide.,O=C([C@H]1CC=CCC1)N1CCC([C@@]2(c3cccnc3)NC(=O)N(CCc3cccs3)C2=O)CC1,amide
+177055,Modify the molecule Cc1nc(C(=O)N(C)[C@@H](C)C2CC2)nn1-c1c(Cl)cccc1Cl by removing a halo.,Cc1nc(C(=O)N(C)[C@@H](C)C2CC2)nn1-c1c(Cl)cccc1Cl,halo
+225734,Please remove a benzene_ring from the molecule O=C([O-])[C@H](c1c[nH]c2cc(F)ccc12)[NH+]1CCN(c2ccccc2)CC1.,O=C([O-])[C@H](c1c[nH]c2cc(F)ccc12)[NH+]1CCN(c2ccccc2)CC1,benzene_ring
+166513,Remove a amine from the molecule CCCN[C@@H](c1ccc[nH+]c1N)[C@H]1C[NH+]2CCN1CC2.,CCCN[C@@H](c1ccc[nH+]c1N)[C@H]1C[NH+]2CCN1CC2,amine
+16221,Please remove a benzene_ring from the molecule O=C(C1CC1)N1CCC[C@H](CNc2ncc3c(n2)CCN3c2ccccc2)C1.,O=C(C1CC1)N1CCC[C@H](CNc2ncc3c(n2)CCN3c2ccccc2)C1,benzene_ring
+74762,Please remove a benzene_ring from the molecule C[C@H](c1ccccc1)n1c([C@H]2CC(=O)N(C3CCCC3)C2)nc2ccccc21.,C[C@H](c1ccccc1)n1c([C@H]2CC(=O)N(C3CCCC3)C2)nc2ccccc21,benzene_ring
+182195,Modify the molecule O=[N+]([O-])c1ccccc1-n1nc(Br)nc1Br by removing a halo.,O=[N+]([O-])c1ccccc1-n1nc(Br)nc1Br,halo
+247636,Remove a amide from the molecule CC(C)CC[S@@](=O)[C@@H](C)C(=O)Nc1cc(Cl)ccc1F.,CC(C)CC[S@@](=O)[C@@H](C)C(=O)Nc1cc(Cl)ccc1F,amide
+221522,Please remove a amide from the molecule CCOC(=O)c1c(NC(=O)c2cc(C)no2)sc2c1CC[NH+](C(C)C)C2.,CCOC(=O)c1c(NC(=O)c2cc(C)no2)sc2c1CC[NH+](C(C)C)C2,amide
+164802,Modify the molecule COC(=O)[C@@]1(NC(=O)CCc2ncc(-c3ccccc3)o2)CCOC1 by removing a benzene_ring.,COC(=O)[C@@]1(NC(=O)CCc2ncc(-c3ccccc3)o2)CCOC1,benzene_ring
+50392,Please remove a halo from the molecule C[C@@H]1CCCN(C(=O)Nc2cc(Br)c(=O)n(C)c2)[C@H]1CO.,C[C@@H]1CCCN(C(=O)Nc2cc(Br)c(=O)n(C)c2)[C@H]1CO,halo
+54617,Remove a amide from the molecule CCCn1/c(=N/C(=O)C[C@H]2CCCCN2C(C)=O)[nH]c2ccccc21.,CCCn1/c(=N/C(=O)C[C@H]2CCCCN2C(C)=O)[nH]c2ccccc21,amide
+114778,Modify the molecule CN(C(=O)c1cc(=O)[nH]c2ccc(Br)cc12)c1ccccc1 by removing a halo.,CN(C(=O)c1cc(=O)[nH]c2ccc(Br)cc12)c1ccccc1,halo
+234885,Remove a amide from the molecule Cc1noc(C)c1C[NH2+][C@@H](C)C(=O)NC1CCCC1.,Cc1noc(C)c1C[NH2+][C@@H](C)C(=O)NC1CCCC1,amide
+205386,Remove a halo from the molecule Cc1cnc(Nc2ccc(NC[C@H]3CCCO3)c(F)c2)c([N+](=O)[O-])c1.,Cc1cnc(Nc2ccc(NC[C@H]3CCCO3)c(F)c2)c([N+](=O)[O-])c1,halo
+64535,Modify the molecule Cc1cc(N(C)C[C@@H](O)COc2ccccc2C(F)(F)F)n2ncnc2n1 by removing a halo.,Cc1cc(N(C)C[C@@H](O)COc2ccccc2C(F)(F)F)n2ncnc2n1,halo
+154081,Please remove a amide from the molecule COc1ccc(Cl)cc1N1C(=O)CS[C@@H]1c1ccccc1F.,COc1ccc(Cl)cc1N1C(=O)CS[C@@H]1c1ccccc1F,amide
+205071,Modify the molecule CN(C)c1c(Cl)cccc1NC(=O)c1cc(F)c(F)cc1[N+](=O)[O-] by removing a nitro.,CN(C)c1c(Cl)cccc1NC(=O)c1cc(F)c(F)cc1[N+](=O)[O-],nitro
+80869,Modify the molecule CC(=O)NC1CCN(C(=O)N[C@@H](c2ccccn2)C(C)C)CC1 by removing a amide.,CC(=O)NC1CCN(C(=O)N[C@@H](c2ccccn2)C(C)C)CC1,amide
+202846,Modify the molecule CCCC(=O)Nc1cccc(NC(=O)N(CC)C[C@H](C)C#N)c1 by removing a nitrile.,CCCC(=O)Nc1cccc(NC(=O)N(CC)C[C@H](C)C#N)c1,nitrile
+187905,Remove a halo from the molecule CCCC[C@H](CC)C(=O)Nc1ccccc1F.,CCCC[C@H](CC)C(=O)Nc1ccccc1F,halo
+156112,Please remove a halo from the molecule Cc1oc(-c2ccc(Cl)cc2)nc1C[NH+]1CCC[C@@H](C(=O)NC2CC2)C1.,Cc1oc(-c2ccc(Cl)cc2)nc1C[NH+]1CCC[C@@H](C(=O)NC2CC2)C1,halo
+113654,Modify the molecule Cc1cc(C)c(C(=O)Nc2ccc3c(c2)CCCN3C)c(=O)[nH]1 by removing a amide.,Cc1cc(C)c(C(=O)Nc2ccc3c(c2)CCCN3C)c(=O)[nH]1,amide
+46721,Remove a amide from the molecule CC(C)CCC(=O)NNC(=O)N1CC[C@H](C)C[C@@H]1C.,CC(C)CCC(=O)NNC(=O)N1CC[C@H](C)C[C@@H]1C,amide
+169815,Remove a benzene_ring from the molecule CC(=O)N(C)c1ccccc1NC(=O)Cc1ccc(NC(=O)C2CC2)cc1.,CC(=O)N(C)c1ccccc1NC(=O)Cc1ccc(NC(=O)C2CC2)cc1,benzene_ring
+122428,Please remove a halo from the molecule CCC[NH+](Cc1nc(Cl)ccc1Cl)C1CCC([NH3+])CC1.,CCC[NH+](Cc1nc(Cl)ccc1Cl)C1CCC([NH3+])CC1,halo
+150300,Please remove a amide from the molecule CSCC(=O)NNC(=O)N[C@@H](C)Cc1c(C)noc1C.,CSCC(=O)NNC(=O)N[C@@H](C)Cc1c(C)noc1C,amide
+212111,Please remove a benzene_ring from the molecule Cc1cc(NC(=O)C(=O)N[C@@H]2CCc3ccccc32)ccc1-n1cnnn1.,Cc1cc(NC(=O)C(=O)N[C@@H]2CCc3ccccc32)ccc1-n1cnnn1,benzene_ring
+115825,Remove a nitrile from the molecule C[C@H](C#N)CNC(=O)C(=O)Nc1ccccc1N1CCCCCC1.,C[C@H](C#N)CNC(=O)C(=O)Nc1ccccc1N1CCCCCC1,nitrile
+132772,Please remove a benzene_ring from the molecule C[C@@H](Sc1nc2sc3c(c2c(=O)n1C)CCC3)C(=O)Nc1ccc(F)c([N+](=O)[O-])c1.,C[C@@H](Sc1nc2sc3c(c2c(=O)n1C)CCC3)C(=O)Nc1ccc(F)c([N+](=O)[O-])c1,benzene_ring
+128600,Modify the molecule Cc1ccn2c(=O)cc(CN(Cc3ccccc3)Cc3ccc(F)cc3)[nH+]c2c1 by removing a benzene_ring.,Cc1ccn2c(=O)cc(CN(Cc3ccccc3)Cc3ccc(F)cc3)[nH+]c2c1,benzene_ring
+227766,Modify the molecule CC[C@@](C)([NH3+])C(=O)NC1CCCCC1 by removing a amide.,CC[C@@](C)([NH3+])C(=O)NC1CCCCC1,amide
+184153,Modify the molecule C[NH+](CC1CCOCC1)C[C@@H]1C[C@@H]1c1ccccc1 by removing a benzene_ring.,C[NH+](CC1CCOCC1)C[C@@H]1C[C@@H]1c1ccccc1,benzene_ring
+62140,Modify the molecule O=C(CCn1cncn1)N1CCC[C@H](c2[nH+]ccn2Cc2ccccc2)C1 by removing a benzene_ring.,O=C(CCn1cncn1)N1CCC[C@H](c2[nH+]ccn2Cc2ccccc2)C1,benzene_ring
+161207,Remove a amide from the molecule O=C(Nc1cccc(S(=O)(=O)N2CCCC2)c1)c1cncn1-c1ccccc1.,O=C(Nc1cccc(S(=O)(=O)N2CCCC2)c1)c1cncn1-c1ccccc1,amide
+85974,Remove a benzene_ring from the molecule COCc1ccccc1C(=O)NC[C@H](O)c1cccc(C(F)(F)F)c1.,COCc1ccccc1C(=O)NC[C@H](O)c1cccc(C(F)(F)F)c1,benzene_ring
+54138,Remove a amide from the molecule Cc1noc(C)c1C[C@@H](C)C(=O)N[C@@H](C#N)C(C)(C)C.,Cc1noc(C)c1C[C@@H](C)C(=O)N[C@@H](C#N)C(C)(C)C,amide
+186079,Remove a benzene_ring from the molecule COc1cc([N+](=O)[O-])ccc1-c1ccc(/C=N\NC(=O)c2ccccc2)o1.,COc1cc([N+](=O)[O-])ccc1-c1ccc(/C=N\NC(=O)c2ccccc2)o1,benzene_ring
+159583,Remove a amine from the molecule CCCS(=O)(=O)[N-]c1ccc(S(=O)(=O)N[C@@H]2CCCC[C@H]2C)cc1F.,CCCS(=O)(=O)[N-]c1ccc(S(=O)(=O)N[C@@H]2CCCC[C@H]2C)cc1F,amine
+34663,Remove a amide from the molecule C[C@H]1CCC[C@@H](N(C)C(=O)Nc2ccc(Cl)c(C(=O)NC3CC3)c2)C1.,C[C@H]1CCC[C@@H](N(C)C(=O)Nc2ccc(Cl)c(C(=O)NC3CC3)c2)C1,amide
+132634,Modify the molecule CCNC(=O)Cn1cnc2cc(-c3ccc(OC)cc3)sc2c1=O by removing a amide.,CCNC(=O)Cn1cnc2cc(-c3ccc(OC)cc3)sc2c1=O,amide
+185188,Modify the molecule COc1ccc2c(C)cc(SCC(=O)N[C@@H](C)c3ccccc3)nc2c1 by removing a benzene_ring.,COc1ccc2c(C)cc(SCC(=O)N[C@@H](C)c3ccccc3)nc2c1,benzene_ring
+28127,Remove a halo from the molecule O=c1[nH]c(CN(CCC(F)(F)F)C2CCCC2)nc2ccccc12.,O=c1[nH]c(CN(CCC(F)(F)F)C2CCCC2)nc2ccccc12,halo
+223910,Remove a nitrile from the molecule COc1ccc(-c2nc(SCC(C)C)nc([O-])c2C#N)cc1.,COc1ccc(-c2nc(SCC(C)C)nc([O-])c2C#N)cc1,nitrile
+231787,Remove a halo from the molecule COC(=O)c1c(C)sc(-c2c(-c3ccc(Cl)cc3)[nH]c3nc([O-])[nH]c(=O)c23)c1O.,COC(=O)c1c(C)sc(-c2c(-c3ccc(Cl)cc3)[nH]c3nc([O-])[nH]c(=O)c23)c1O,halo
+185721,Remove a amide from the molecule Cc1cc(C)n(CCNC(=O)c2ccc([C@H]3CCC[NH+]3C(C)C)s2)n1.,Cc1cc(C)n(CCNC(=O)c2ccc([C@H]3CCC[NH+]3C(C)C)s2)n1,amide
+193858,Please remove a amide from the molecule CCN(CCNC(=O)[C@H]1CC(=O)N(C2CC2)C1)c1ccccc1C.,CCN(CCNC(=O)[C@H]1CC(=O)N(C2CC2)C1)c1ccccc1C,amide
+171923,Modify the molecule C[C@@H](CCl)CSc1ncnc2c1CCC2 by removing a halo.,C[C@@H](CCl)CSc1ncnc2c1CCC2,halo
+249351,Modify the molecule CC(=O)c1ccc(NCC(C)(C)N2CCOCC2)c([N+](=O)[O-])c1 by removing a nitro.,CC(=O)c1ccc(NCC(C)(C)N2CCOCC2)c([N+](=O)[O-])c1,nitro
+121865,Modify the molecule O=C(Nc1nc2ccc(F)cc2s1)c1ccccc1[N-]S(=O)(=O)c1ccccc1 by removing a benzene_ring.,O=C(Nc1nc2ccc(F)cc2s1)c1ccccc1[N-]S(=O)(=O)c1ccccc1,benzene_ring
+92168,Remove a amide from the molecule C[NH+](C)[C@@H](CNC(=O)CCc1ccc(Cl)s1)c1ccc(Cl)cc1.,C[NH+](C)[C@@H](CNC(=O)CCc1ccc(Cl)s1)c1ccc(Cl)cc1,amide
+186229,Remove a benzene_ring from the molecule CNC(=O)c1ccc(OC)c(NC(=O)NCc2cccnc2)c1.,CNC(=O)c1ccc(OC)c(NC(=O)NCc2cccnc2)c1,benzene_ring
+82789,Modify the molecule Cc1cc([C@@H](C)[NH2+]Cc2cnn(-c3ccc(F)cc3)c2)c(C)s1 by removing a halo.,Cc1cc([C@@H](C)[NH2+]Cc2cnn(-c3ccc(F)cc3)c2)c(C)s1,halo
+124979,Modify the molecule C[C@H](Nc1ccc2c(c1)OCCCO2)C(=O)Nc1ccccc1[N+](=O)[O-] by removing a nitro.,C[C@H](Nc1ccc2c(c1)OCCCO2)C(=O)Nc1ccccc1[N+](=O)[O-],nitro
+93750,Modify the molecule C[C@H]1C[C@@H]1C(=O)N1CCN(C(=O)c2cnc(Oc3ccccc3)cn2)CC1 by removing a amide.,C[C@H]1C[C@@H]1C(=O)N1CCN(C(=O)c2cnc(Oc3ccccc3)cn2)CC1,amide
+76912,Remove a amide from the molecule Cc1c(C(=O)N[C@@H](C)CNc2nc3c(c(=O)[nH]2)CCCC3)oc2ccccc12.,Cc1c(C(=O)N[C@@H](C)CNc2nc3c(c(=O)[nH]2)CCCC3)oc2ccccc12,amide
+90797,Modify the molecule COc1cc([C@H](C)[NH2+][C@@H]2CCOc3cc(C)c(C)cc32)ccc1F by removing a halo.,COc1cc([C@H](C)[NH2+][C@@H]2CCOc3cc(C)c(C)cc32)ccc1F,halo
+101928,Please remove a amide from the molecule CC[C@@H]1CC(=O)N(C[C@H]([NH2+]C)C2CC2)C1.,CC[C@@H]1CC(=O)N(C[C@H]([NH2+]C)C2CC2)C1,amide
+141314,Please remove a amine from the molecule CCc1nn(C)c(NC[C@@H]2C[C@@H]2c2ccccc2)c1[N+](=O)[O-].,CCc1nn(C)c(NC[C@@H]2C[C@@H]2c2ccccc2)c1[N+](=O)[O-],amine
+232564,Remove a amide from the molecule COc1cc(/C=C/C(=O)N2CCCC[C@H]2C)cc2c1OCCO2.,COc1cc(/C=C/C(=O)N2CCCC[C@H]2C)cc2c1OCCO2,amide
+126053,Modify the molecule CN(CC(C)(C)O)C(=O)c1cccc(OC(F)F)c1 by removing a benzene_ring.,CN(CC(C)(C)O)C(=O)c1cccc(OC(F)F)c1,benzene_ring
+100111,Remove a amide from the molecule C[C@H](NC(=O)Cc1c(Cl)cccc1Cl)c1ccc(S(=O)(=O)N(C)C)cc1.,C[C@H](NC(=O)Cc1c(Cl)cccc1Cl)c1ccc(S(=O)(=O)N(C)C)cc1,amide
+206749,Remove a amide from the molecule COc1ccc([N+](=O)[O-])cc1NC(=O)[C@H](C)SC1=NCCS1.,COc1ccc([N+](=O)[O-])cc1NC(=O)[C@H](C)SC1=NCCS1,amide
+24123,Please remove a nitro from the molecule COC(=O)CCCc1nc2ccc([N+](=O)[O-])cc2s1.,COC(=O)CCCc1nc2ccc([N+](=O)[O-])cc2s1,nitro
+87140,Remove a benzene_ring from the molecule Cc1nn(CC(C)C)c2sc(C(=O)N[C@H](C)c3ccccc3)cc12.,Cc1nn(CC(C)C)c2sc(C(=O)N[C@H](C)c3ccccc3)cc12,benzene_ring
+54236,Remove a amide from the molecule Cc1cc([C@@H]2CCCN(C(=O)c3c[nH]c(C(C)C)n3)C2)n[nH]1.,Cc1cc([C@@H]2CCCN(C(=O)c3c[nH]c(C(C)C)n3)C2)n[nH]1,amide
+211698,Please remove a amide from the molecule CCN(CC(=O)Nc1ccc2c(c1)OCCO2)C(=O)C=C1CCCCC1.,CCN(CC(=O)Nc1ccc2c(c1)OCCO2)C(=O)C=C1CCCCC1,amide
+220103,Remove a amide from the molecule C=CCNC(=O)CN1CCOC[C@H]1C#N.,C=CCNC(=O)CN1CCOC[C@H]1C#N,amide
+175026,Please remove a benzene_ring from the molecule CC1(C)[C@H]2CC[C@]1(C)[C@H](NC(=O)c1ccccc1)C2.,CC1(C)[C@H]2CC[C@]1(C)[C@H](NC(=O)c1ccccc1)C2,benzene_ring
+211524,Remove a benzene_ring from the molecule N#Cc1ccc(C(=O)Nc2nnc(-c3ccc(Br)s3)o2)cc1.,N#Cc1ccc(C(=O)Nc2nnc(-c3ccc(Br)s3)o2)cc1,benzene_ring
+41787,Remove a benzene_ring from the molecule COc1cc(OC)cc([C@H]2CCN(C(=O)[C@@H]3CCO[C@H]3C)C2)c1.,COc1cc(OC)cc([C@H]2CCN(C(=O)[C@@H]3CCO[C@H]3C)C2)c1,benzene_ring
+39545,Please remove a benzene_ring from the molecule COc1ccc(-c2csc(NC(=O)NC[C@@H]3CCCO3)n2)cc1.,COc1ccc(-c2csc(NC(=O)NC[C@@H]3CCCO3)n2)cc1,benzene_ring
+246440,Modify the molecule CC[C@@H](C)CN(C)C(=O)Nc1ccc(F)c(C(=O)N(C)C)c1 by removing a benzene_ring.,CC[C@@H](C)CN(C)C(=O)Nc1ccc(F)c(C(=O)N(C)C)c1,benzene_ring
+230340,Remove a halo from the molecule CCCNC(=O)NCc1cc[nH+]c(N2CCN(c3ccc(F)cc3)CC2)c1.,CCCNC(=O)NCc1cc[nH+]c(N2CCN(c3ccc(F)cc3)CC2)c1,halo
+60481,Please remove a amide from the molecule O=C1[C@@H](Sc2nc3ccccc3o2)CCN1c1c(F)cccc1F.,O=C1[C@@H](Sc2nc3ccccc3o2)CCN1c1c(F)cccc1F,amide
+24593,Please remove a amide from the molecule N#Cc1ccc(C(=O)N2CCCS/C2=N\c2cccc(C(F)(F)F)c2)cc1.,N#Cc1ccc(C(=O)N2CCCS/C2=N\c2cccc(C(F)(F)F)c2)cc1,amide
+194918,Modify the molecule CCOc1ccc2nc(N3CCC[C@@H]3C(=O)N(C)CCc3ccccn3)nc(C)c2c1 by removing a amide.,CCOc1ccc2nc(N3CCC[C@@H]3C(=O)N(C)CCc3ccccn3)nc(C)c2c1,amide
+131315,Modify the molecule CC(=O)C1=C(C)[C@@H](C(=O)N2CCN(c3cccc(C)c3C)CC2)N=C1C by removing a amide.,CC(=O)C1=C(C)[C@@H](C(=O)N2CCN(c3cccc(C)c3C)CC2)N=C1C,amide
+45775,Modify the molecule Cc1nc(CC(CO)(CO)Cc2ccccc2)sc1C by removing a benzene_ring.,Cc1nc(CC(CO)(CO)Cc2ccccc2)sc1C,benzene_ring
+107239,Modify the molecule O=C(CSc1ncnc2ccsc12)c1cc(F)ccc1F by removing a halo.,O=C(CSc1ncnc2ccsc12)c1cc(F)ccc1F,halo
+196414,Please remove a hydroxyl from the molecule CCC[NH2+][C@@]1(CO)CC[C@@H](n2c(C)nc3ccccc32)C1.,CCC[NH2+][C@@]1(CO)CC[C@@H](n2c(C)nc3ccccc32)C1,hydroxyl
+227318,Remove a halo from the molecule Cc1c(Cl)cccc1S(=O)(=O)NC[C@H](c1cccs1)N(C)C.,Cc1c(Cl)cccc1S(=O)(=O)NC[C@H](c1cccs1)N(C)C,halo
+213397,Remove a amide from the molecule Cc1csc(NC(=O)c2cnc([C@@H]3CCC[NH+](C)C3)cn2)n1.,Cc1csc(NC(=O)c2cnc([C@@H]3CCC[NH+](C)C3)cn2)n1,amide
+165929,Remove a amine from the molecule CCc1cccc(N[C@@H]2c3ncccc3C(=O)N2c2cc(OC)ccc2OC)c1.,CCc1cccc(N[C@@H]2c3ncccc3C(=O)N2c2cc(OC)ccc2OC)c1,amine
+58351,Please remove a amine from the molecule CCN[C@H](c1cc(C)cnc1N)C(C)(C)[NH+](C)C.,CCN[C@H](c1cc(C)cnc1N)C(C)(C)[NH+](C)C,amine
+114805,Please remove a hydroxyl from the molecule C[C@H](NC(=O)N[C@H](C)[C@@H](C)CO)c1cccc(N2CCCC2)c1.,C[C@H](NC(=O)N[C@H](C)[C@@H](C)CO)c1cccc(N2CCCC2)c1,hydroxyl
+189974,Modify the molecule CC[C@H](C)NC(=O)[C@H]1CC[C@H](c2ccccc2)N(C(C)=O)C1 by removing a benzene_ring.,CC[C@H](C)NC(=O)[C@H]1CC[C@H](c2ccccc2)N(C(C)=O)C1,benzene_ring
+23455,Please remove a amide from the molecule C[C@@H](NC(=O)[C@H]1CC=CCC1)c1ccc(F)c(F)c1.,C[C@@H](NC(=O)[C@H]1CC=CCC1)c1ccc(F)c(F)c1,amide
+40257,Please remove a halo from the molecule O=C(NCCc1nc2ccccc2s1)c1ccc(OCC(F)F)nc1.,O=C(NCCc1nc2ccccc2s1)c1ccc(OCC(F)F)nc1,halo
+104408,Modify the molecule C[C@H]1c2ccccc2O[C@@H]1C(=O)OCc1cc(Cl)c2c(c1)OCO2 by removing a halo.,C[C@H]1c2ccccc2O[C@@H]1C(=O)OCc1cc(Cl)c2c(c1)OCO2,halo
+20512,Remove a halo from the molecule Cc1ccc(NC(=O)C[n+]2ccc(Cc3ccccc3)cc2)cc1Cl.,Cc1ccc(NC(=O)C[n+]2ccc(Cc3ccccc3)cc2)cc1Cl,halo
+224288,Modify the molecule CS[C@@H](C#N)C(F)(F)F by removing a halo.,CS[C@@H](C#N)C(F)(F)F,halo
+66403,Modify the molecule CC(C)c1nnsc1CNC(=O)c1nc2ccccn2c1F by removing a halo.,CC(C)c1nnsc1CNC(=O)c1nc2ccccn2c1F,halo
+156575,Please remove a benzene_ring from the molecule COc1ccccc1OCC[NH2+]C[C@@]1(C)CC(C)=NO1.,COc1ccccc1OCC[NH2+]C[C@@]1(C)CC(C)=NO1,benzene_ring
+225543,Modify the molecule COc1cc(NC(=O)C[NH+]2CCCN(c3ncccn3)CC2)ccc1Cl by removing a halo.,COc1cc(NC(=O)C[NH+]2CCCN(c3ncccn3)CC2)ccc1Cl,halo
+106946,Please remove a halo from the molecule CCOC(=O)C(F)(F)Oc1cc(C)ccc1C.,CCOC(=O)C(F)(F)Oc1cc(C)ccc1C,halo
+205953,Modify the molecule Cc1cc(C)cc(CCNC(=O)N(C)[C@H](C)c2ccco2)c1 by removing a benzene_ring.,Cc1cc(C)cc(CCNC(=O)N(C)[C@H](C)c2ccco2)c1,benzene_ring
+104685,Remove a amine from the molecule Cn1cc[nH+]c1[C@@H](NCC(C)(C)S(C)(=O)=O)c1cccs1.,Cn1cc[nH+]c1[C@@H](NCC(C)(C)S(C)(=O)=O)c1cccs1,amine
+225419,Remove a amine from the molecule Nc1ccc(COCc2ccccc2)c2ncccc12.,Nc1ccc(COCc2ccccc2)c2ncccc12,amine
+194300,Remove a amine from the molecule Cn1cnnc1CCn1nnnc1N.,Cn1cnnc1CCn1nnnc1N,amine
+180209,Please remove a amide from the molecule Cc1ccc(NC(=O)c2[nH]nc([N+](=O)[O-])c2Br)c(C)c1.,Cc1ccc(NC(=O)c2[nH]nc([N+](=O)[O-])c2Br)c(C)c1,amide
+191905,Modify the molecule C[NH2+]C[C@H](C)C(=O)N1CC[C@H](C)[C@H]2CCCC[C@@H]21 by removing a amide.,C[NH2+]C[C@H](C)C(=O)N1CC[C@H](C)[C@H]2CCCC[C@@H]21,amide
+233001,Please remove a benzene_ring from the molecule COc1ccc(CN2CC[NH+](C)[C@@]3(CCNC(=O)CC3)C2)cc1Cn1cccn1.,COc1ccc(CN2CC[NH+](C)[C@@]3(CCNC(=O)CC3)C2)cc1Cn1cccn1,benzene_ring
+23943,Modify the molecule CN(Cc1ccc2c(c1)OCO2)C(=O)c1ccc2ccc(Cl)cc2n1 by removing a halo.,CN(Cc1ccc2c(c1)OCO2)C(=O)c1ccc2ccc(Cl)cc2n1,halo
+236121,Please remove a benzene_ring from the molecule CCOc1ccc(-n2c(-c3ccccc3)c(CC)n3c4c(=O)n(C)c(=O)n(C)c4nc23)cc1.,CCOc1ccc(-n2c(-c3ccccc3)c(CC)n3c4c(=O)n(C)c(=O)n(C)c4nc23)cc1,benzene_ring
+20725,Remove a nitrile from the molecule C[C@@H](c1ccccc1)[NH+](C)CCOc1ccc(C#N)cc1.,C[C@@H](c1ccccc1)[NH+](C)CCOc1ccc(C#N)cc1,nitrile
+166022,Please remove a benzene_ring from the molecule Cc1ccc(Br)cc1S(=O)(=O)N1CCC[C@H](N2CCCC2=O)C1.,Cc1ccc(Br)cc1S(=O)(=O)N1CCC[C@H](N2CCCC2=O)C1,benzene_ring
+200076,Modify the molecule O=C(Nc1ccc(N2CCOCC2)cc1C(F)(F)F)NC1CCCCCC1 by removing a benzene_ring.,O=C(Nc1ccc(N2CCOCC2)cc1C(F)(F)F)NC1CCCCCC1,benzene_ring
+113041,Please remove a amine from the molecule C[C@H]1C[C@@H]([NH3+])CN(Cc2nc(N)nc(N(C)C)n2)C1.,C[C@H]1C[C@@H]([NH3+])CN(Cc2nc(N)nc(N(C)C)n2)C1,amine
+231004,Modify the molecule Cc1nc(N2CCC[C@@H]2C(=O)NCCC2=CC[C@@H]3C[C@H]2C3(C)C)nc2cc(S(C)(=O)=O)ccc12 by removing a amide.,Cc1nc(N2CCC[C@@H]2C(=O)NCCC2=CC[C@@H]3C[C@H]2C3(C)C)nc2cc(S(C)(=O)=O)ccc12,amide
+79413,Please remove a amide from the molecule CNC(=O)[C@@H](C)n1c2ccccc2c2cn[nH]c(=O)c21.,CNC(=O)[C@@H](C)n1c2ccccc2c2cn[nH]c(=O)c21,amide
+50476,Modify the molecule C[C@@H]1C[NH+](Cc2c[nH]nc2-c2ccc(F)cc2)CC[C@@]1(O)C1CCOCC1 by removing a hydroxyl.,C[C@@H]1C[NH+](Cc2c[nH]nc2-c2ccc(F)cc2)CC[C@@]1(O)C1CCOCC1,hydroxyl
+57261,Modify the molecule CCOC[C@H]1CCN(C(=O)N[C@@H](C)c2ccc(-n3cncn3)cc2)C1 by removing a benzene_ring.,CCOC[C@H]1CCN(C(=O)N[C@@H](C)c2ccc(-n3cncn3)cc2)C1,benzene_ring
+60135,Modify the molecule CCn1nc(C)c(C[NH2+]Cc2cn(-c3ccc(F)cc3F)nc2-c2ccccc2C)c1C by removing a benzene_ring.,CCn1nc(C)c(C[NH2+]Cc2cn(-c3ccc(F)cc3F)nc2-c2ccccc2C)c1C,benzene_ring
+202632,Remove a amide from the molecule C#Cc1cccc(NC(=O)C(=O)NC2CCN(C(=O)c3ccco3)CC2)c1.,C#Cc1cccc(NC(=O)C(=O)NC2CCN(C(=O)c3ccco3)CC2)c1,amide
+99742,Please remove a amide from the molecule COc1cc2c(cc1OC)CCN(C(=O)c1cnn(C)c1C)CC2.,COc1cc2c(cc1OC)CCN(C(=O)c1cnn(C)c1C)CC2,amide
+154577,Modify the molecule C=C(C)CN(CC)C(=O)CN1CCN(C(=O)C[NH+](C)C)CC1 by removing a amide.,C=C(C)CN(CC)C(=O)CN1CCN(C(=O)C[NH+](C)C)CC1,amide
+223290,Please remove a amide from the molecule Cc1ccc(N2CCOC2=O)cc1NC(=O)[C@H](C)Sc1ccccc1.,Cc1ccc(N2CCOC2=O)cc1NC(=O)[C@H](C)Sc1ccccc1,amide
+71599,Remove a amine from the molecule C[C@@H]1CN(C(=O)c2cn[nH]c2N)C[C@H]1C.,C[C@@H]1CN(C(=O)c2cn[nH]c2N)C[C@H]1C,amine
+54086,Remove a nitrile from the molecule CCOC(=O)C[C@H](C)Nc1snc(Cl)c1C#N.,CCOC(=O)C[C@H](C)Nc1snc(Cl)c1C#N,nitrile
+23755,Remove a amide from the molecule CCc1ccc(-c2nc(CC(=O)Nc3nc(C)c(C)s3)cs2)cc1.,CCc1ccc(-c2nc(CC(=O)Nc3nc(C)c(C)s3)cs2)cc1,amide
+201362,Remove a amide from the molecule N#Cc1cn(C2CC2)c(=O)n(CC(=O)N2CCN(C(=O)c3ccco3)CC2)c1=O.,N#Cc1cn(C2CC2)c(=O)n(CC(=O)N2CCN(C(=O)c3ccco3)CC2)c1=O,amide
+112618,Modify the molecule Cc1cccc([S@@](=O)CCC(=O)Nc2cc(F)cc(F)c2)c1 by removing a amide.,Cc1cccc([S@@](=O)CCC(=O)Nc2cc(F)cc(F)c2)c1,amide
+243204,Please remove a halo from the molecule Cc1ccc(-n2nc(C)c(CC(=O)Oc3ccc(C(N)=O)cc3)c2C)cc1Cl.,Cc1ccc(-n2nc(C)c(CC(=O)Oc3ccc(C(N)=O)cc3)c2C)cc1Cl,halo
+184141,Please remove a amide from the molecule C[C@H]1Nc2ccccc2C[C@@H]1C(=O)N[C@@H]1CCCC1(C)C.,C[C@H]1Nc2ccccc2C[C@@H]1C(=O)N[C@@H]1CCCC1(C)C,amide
+93208,Please remove a amide from the molecule CCOC(=O)c1ccc(NC(=O)c2oc3c(c2C)/C(=N/NC(N)=S)CCC3)cc1.,CCOC(=O)c1ccc(NC(=O)c2oc3c(c2C)/C(=N/NC(N)=S)CCC3)cc1,amide
+76526,Remove a amide from the molecule Cc1ccc(CCNC(=O)CCn2cnc3onc(-c4ccc(F)cc4)c3c2=O)cc1.,Cc1ccc(CCNC(=O)CCn2cnc3onc(-c4ccc(F)cc4)c3c2=O)cc1,amide
+123565,Modify the molecule COc1ccc(C2=C[C@H](C(=O)N3CCN(C(=O)c4ccco4)CC3)N=N2)cc1 by removing a amide.,COc1ccc(C2=C[C@H](C(=O)N3CCN(C(=O)c4ccco4)CC3)N=N2)cc1,amide
+74755,Remove a benzene_ring from the molecule COc1ccc(COCCNC(=O)N2CC[C@@H]3CCCC[C@H]32)cc1.,COc1ccc(COCCNC(=O)N2CC[C@@H]3CCCC[C@H]32)cc1,benzene_ring
+198876,Please remove a nitrile from the molecule COc1cc(OC)cc([C@@H]2CCN(Cc3ccc(F)cc3C#N)C2)c1.,COc1cc(OC)cc([C@@H]2CCN(Cc3ccc(F)cc3C#N)C2)c1,nitrile
+53851,Remove a amide from the molecule CC(C)n1ccc2ccc(C(=O)NCc3nnc4ccccn34)cc21.,CC(C)n1ccc2ccc(C(=O)NCc3nnc4ccccn34)cc21,amide
+9524,Remove a benzene_ring from the molecule O=C(Nc1ccccc1Oc1ccccc1)N1CCOCC1.,O=C(Nc1ccccc1Oc1ccccc1)N1CCOCC1,benzene_ring
+9991,Remove a hydroxyl from the molecule Cc1cccc(-n2ncc3c(O)nc(SCC(N)=O)nc32)c1C.,Cc1cccc(-n2ncc3c(O)nc(SCC(N)=O)nc32)c1C,hydroxyl
+178416,Modify the molecule C[C@H]1C[C@H]1C(=O)OCC(=O)Nc1cc(S(C)(=O)=O)ccc1Cl by removing a halo.,C[C@H]1C[C@H]1C(=O)OCC(=O)Nc1cc(S(C)(=O)=O)ccc1Cl,halo
+184774,Remove a benzene_ring from the molecule CC(C)[NH2+]Cc1c[nH]nc1-c1ccc(C(C)(C)C)cc1.,CC(C)[NH2+]Cc1c[nH]nc1-c1ccc(C(C)(C)C)cc1,benzene_ring
+77064,Please remove a amide from the molecule CN(CC(=O)N[C@H](C#N)C(C)(C)C)C(=O)c1ccc(Br)o1.,CN(CC(=O)N[C@H](C#N)C(C)(C)C)C(=O)c1ccc(Br)o1,amide
+60216,Remove a benzene_ring from the molecule CCCc1cc(C(=O)N(C)[C@H](C)c2cc(-c3ccccc3)[nH]n2)n(C)n1.,CCCc1cc(C(=O)N(C)[C@H](C)c2cc(-c3ccccc3)[nH]n2)n(C)n1,benzene_ring
+195815,Please remove a benzene_ring from the molecule Cc1noc(C)c1CCCNC(=O)N(C)Cc1c(F)cccc1Cl.,Cc1noc(C)c1CCCNC(=O)N(C)Cc1c(F)cccc1Cl,benzene_ring
+168122,Remove a amide from the molecule N#Cc1cccc(/C=C/C(=O)N2CCCCC[C@@H]2c2ccncc2)c1.,N#Cc1cccc(/C=C/C(=O)N2CCCCC[C@@H]2c2ccncc2)c1,amide
+123756,Please remove a amide from the molecule COc1ccc2c(c1)CCCN2C(=O)C[NH+]1CCC[C@@H]1c1ccc(OC)c(OC)c1.,COc1ccc2c(c1)CCCN2C(=O)C[NH+]1CCC[C@@H]1c1ccc(OC)c(OC)c1,amide
+188854,Remove a amide from the molecule Cc1cc(C(=O)NCc2cccnc2)nc(N(C)C)n1.,Cc1cc(C(=O)NCc2cccnc2)nc(N(C)C)n1,amide
+6340,Modify the molecule C[C@H](NC(=O)OCc1ccccc1)C(O)(O)C(=O)CCl by removing a halo.,C[C@H](NC(=O)OCc1ccccc1)C(O)(O)C(=O)CCl,halo
+226988,Remove a benzene_ring from the molecule Cc1ccc(O[C@@H](C)C(=O)N2CCC(C(N)=O)CC2)cc1.,Cc1ccc(O[C@@H](C)C(=O)N2CCC(C(N)=O)CC2)cc1,benzene_ring
+170385,Please remove a amide from the molecule CCC(CC)(CO)CNC(=O)c1ccc2c(c1)COCO2.,CCC(CC)(CO)CNC(=O)c1ccc2c(c1)COCO2,amide
+239787,Please remove a amide from the molecule C[C@@H]1CCC[C@@H](NC(=O)CN2C(=O)NC3(CCC(C(C)(C)C)CC3)C2=O)[C@@H]1C.,C[C@@H]1CCC[C@@H](NC(=O)CN2C(=O)NC3(CCC(C(C)(C)C)CC3)C2=O)[C@@H]1C,amide
+245506,Modify the molecule Fc1cccc(/N=C(\[S-])Nc2ccc(Br)cc2)c1 by removing a halo.,Fc1cccc(/N=C(\[S-])Nc2ccc(Br)cc2)c1,halo
+30692,Remove a amide from the molecule CCN(CC)C(=O)CCC(=O)N1CCC[C@@H](C)[C@@H]1c1ccc(C)cc1.,CCN(CC)C(=O)CCC(=O)N1CCC[C@@H](C)[C@@H]1c1ccc(C)cc1,amide
+156973,Remove a benzene_ring from the molecule O=[N+]([O-])c1cnn(C[C@H](CS)c2ccccc2)c1.,O=[N+]([O-])c1cnn(C[C@H](CS)c2ccccc2)c1,benzene_ring
+158175,Remove a amine from the molecule CC[C@@H]1CSC(NC2CCCCCCC2)=[NH+]1.,CC[C@@H]1CSC(NC2CCCCCCC2)=[NH+]1,amine
+24594,Remove a amide from the molecule O=C(CC[NH2+][C@@H]1CCOC2(CCCCC2)C1)NC1CC1.,O=C(CC[NH2+][C@@H]1CCOC2(CCCCC2)C1)NC1CC1,amide
+190143,Modify the molecule C[C@@H]1CC(C)(C)CC[C@H]1NC(=O)N1CCN(C(=O)c2ccncc2)CC1 by removing a amide.,C[C@@H]1CC(C)(C)CC[C@H]1NC(=O)N1CCN(C(=O)c2ccncc2)CC1,amide
+175794,Please remove a amide from the molecule CCCCCN1CC(=O)N2[C@@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc(C)cc2)C1=O.,CCCCCN1CC(=O)N2[C@@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc(C)cc2)C1=O,amide
+59630,Remove a amide from the molecule CN1C(=O)NC(=O)[C@]2(Cc3ccccc3N3CCN(Cc4ccc5c(c4)OCO5)C[C@@H]32)C1=O.,CN1C(=O)NC(=O)[C@]2(Cc3ccccc3N3CCN(Cc4ccc5c(c4)OCO5)C[C@@H]32)C1=O,amide
+99195,Please remove a benzene_ring from the molecule COC(=O)c1ccc(-c2csc(NC(=O)[C@@H]3CCCN3S(=O)(=O)c3ccc(C)cc3)n2)cc1.,COC(=O)c1ccc(-c2csc(NC(=O)[C@@H]3CCCN3S(=O)(=O)c3ccc(C)cc3)n2)cc1,benzene_ring
+51563,Modify the molecule CCS(=O)(=O)N[C@H](C)CCc1ccccc1 by removing a amine.,CCS(=O)(=O)N[C@H](C)CCc1ccccc1,amine
+194316,Remove a benzene_ring from the molecule CCOc1ccc([C@@H](C)NC(=O)Nc2ccc(NC(=O)C3CC3)cc2)cc1.,CCOc1ccc([C@@H](C)NC(=O)Nc2ccc(NC(=O)C3CC3)cc2)cc1,benzene_ring
+187570,Please remove a amine from the molecule Cc1nc(CCNc2nccc(-c3cc(C(=O)[O-])ccn3)n2)cc(=O)[nH]1.,Cc1nc(CCNc2nccc(-c3cc(C(=O)[O-])ccn3)n2)cc(=O)[nH]1,amine
+6862,Please remove a halo from the molecule C[C@H]1C[C@H]([NH3+])CN(S(=O)(=O)c2c(F)cc(F)cc2F)C1.,C[C@H]1C[C@H]([NH3+])CN(S(=O)(=O)c2c(F)cc(F)cc2F)C1,halo
+171465,Modify the molecule Cc1ccc(NC(=O)Cn2c(=O)ncc3cc(S(=O)(=O)N4CCCC[C@@H]4C)ccc32)c(C)c1 by removing a amide.,Cc1ccc(NC(=O)Cn2c(=O)ncc3cc(S(=O)(=O)N4CCCC[C@@H]4C)ccc32)c(C)c1,amide
+109380,Please remove a nitro from the molecule CC[C@H](c1ccncc1)[NH+](C)Cc1csc([N+](=O)[O-])c1.,CC[C@H](c1ccncc1)[NH+](C)Cc1csc([N+](=O)[O-])c1,nitro
+207962,Modify the molecule O=c1[nH]cnc2cc(-c3ccc(Cl)cc3)sc12 by removing a halo.,O=c1[nH]cnc2cc(-c3ccc(Cl)cc3)sc12,halo
+129603,Modify the molecule CCc1nnc(NC(=O)N2C[C@H](C)O[C@H](c3ccccc3)C2)s1 by removing a benzene_ring.,CCc1nnc(NC(=O)N2C[C@H](C)O[C@H](c3ccccc3)C2)s1,benzene_ring
+49902,Modify the molecule COc1ccc(OC)c(NC(=O)N2CCC[C@@H](OC)C2)c1 by removing a benzene_ring.,COc1ccc(OC)c(NC(=O)N2CCC[C@@H](OC)C2)c1,benzene_ring
+131995,Remove a hydroxyl from the molecule CCN(CC(C)(C)O)C(=O)Cc1nc(CCl)cs1.,CCN(CC(C)(C)O)C(=O)Cc1nc(CCl)cs1,hydroxyl
+100281,Remove a amide from the molecule CS(=O)(=O)Nc1cccc(C(=O)Nc2ccc(F)cc2)c1.,CS(=O)(=O)Nc1cccc(C(=O)Nc2ccc(F)cc2)c1,amide
+144065,Please remove a halo from the molecule CC(=O)N1CCC([NH+]2CC[C@H](c3nc4cc(F)ccc4o3)C2)CC1.,CC(=O)N1CCC([NH+]2CC[C@H](c3nc4cc(F)ccc4o3)C2)CC1,halo
+70193,Remove a benzene_ring from the molecule CSc1nc2ccccc2c(Nc2ccc(C(C)=O)cc2)c1C#N.,CSc1nc2ccccc2c(Nc2ccc(C(C)=O)cc2)c1C#N,benzene_ring
+56385,Remove a amide from the molecule Cc1cccc(NC(=O)C(=O)NCc2ccc(C[NH+](C)C)cc2)c1Cl.,Cc1cccc(NC(=O)C(=O)NCc2ccc(C[NH+](C)C)cc2)c1Cl,amide
+77091,Remove a benzene_ring from the molecule COc1cccc(/C(C)=C/C(=O)Nc2cc(C(=O)NC3CC3)ccc2C)c1.,COc1cccc(/C(C)=C/C(=O)Nc2cc(C(=O)NC3CC3)ccc2C)c1,benzene_ring
+47050,Please remove a benzene_ring from the molecule C[C@H]1C[C@H]1c1ccc([C@H](O)Cc2ccc(O)cc2)o1.,C[C@H]1C[C@H]1c1ccc([C@H](O)Cc2ccc(O)cc2)o1,benzene_ring
+96480,Modify the molecule CC(C)N(C)C(=O)C1CCN(S(=O)(=O)c2cccnc2)CC1 by removing a amide.,CC(C)N(C)C(=O)C1CCN(S(=O)(=O)c2cccnc2)CC1,amide
+236562,Remove a hydroxyl from the molecule CC(C)[C@H](Cc1ccccc1Br)[NH2+]CC1(CO)CCOCC1.,CC(C)[C@H](Cc1ccccc1Br)[NH2+]CC1(CO)CCOCC1,hydroxyl
+220902,Remove a amide from the molecule CC(C)CCO[C@H]1CCCC[C@H]1NC(=O)c1cc2c([nH]c1=O)CCCC2=O.,CC(C)CCO[C@H]1CCCC[C@H]1NC(=O)c1cc2c([nH]c1=O)CCCC2=O,amide
+114795,Please remove a amide from the molecule O=C(NCC1(c2ccc(Cl)cc2)CCOCC1)c1cccnc1N1CCCC1.,O=C(NCC1(c2ccc(Cl)cc2)CCOCC1)c1cccnc1N1CCCC1,amide
+31060,Modify the molecule N#Cc1ccccc1COc1cccc(C=O)c1 by removing a benzene_ring.,N#Cc1ccccc1COc1cccc(C=O)c1,benzene_ring
+62942,Please remove a amide from the molecule O=C(Nc1cccc(C(=O)OCC(F)(F)F)c1)c1cccnc1.,O=C(Nc1cccc(C(=O)OCC(F)(F)F)c1)c1cccnc1,amide
+218776,Please remove a amide from the molecule Cc1ccc(NC(=O)C2CC2)cc1NC(=O)[C@@H](C)c1cccs1.,Cc1ccc(NC(=O)C2CC2)cc1NC(=O)[C@@H](C)c1cccs1,amide
+13788,Please remove a halo from the molecule CCc1nnc(SCC(=O)Nc2c(Cl)cccc2Cl)n1-n1cccc1.,CCc1nnc(SCC(=O)Nc2c(Cl)cccc2Cl)n1-n1cccc1,halo
+10883,Remove a benzene_ring from the molecule Cc1ccc(CCC(=O)N[C@@H](c2ccccc2)c2ccncc2)cc1.,Cc1ccc(CCC(=O)N[C@@H](c2ccccc2)c2ccncc2)cc1,benzene_ring
+140820,Remove a hydroxyl from the molecule COc1cc(S(=O)(=O)Nc2ccccc2O)c(OC)cc1C.,COc1cc(S(=O)(=O)Nc2ccccc2O)c(OC)cc1C,hydroxyl
+142414,Please remove a benzene_ring from the molecule C[C@H](CO)NC(=O)N[C@H](Cc1ccccc1)C1CC1.,C[C@H](CO)NC(=O)N[C@H](Cc1ccccc1)C1CC1,benzene_ring
+99778,Please remove a amide from the molecule C[C@H]1CCC[C@H](CC[NH+]2CCNC(=O)C2)C1.,C[C@H]1CCC[C@H](CC[NH+]2CCNC(=O)C2)C1,amide
+72118,Remove a benzene_ring from the molecule O=C(NC[C@H]1C[C@@]12CCc1ccccc12)N[C@@H](CO)c1ccc(Cl)cc1.,O=C(NC[C@H]1C[C@@]12CCc1ccccc12)N[C@@H](CO)c1ccc(Cl)cc1,benzene_ring
+160845,Modify the molecule O=C(C=C1CCSCC1)NNC(=O)Cc1ccsc1 by removing a amide.,O=C(C=C1CCSCC1)NNC(=O)Cc1ccsc1,amide
+136004,Please remove a amide from the molecule CCn1cc(C(=O)N(CCc2cccs2)Cc2cccnc2)c(=O)c2ccc(C)nc21.,CCn1cc(C(=O)N(CCc2cccs2)Cc2cccnc2)c(=O)c2ccc(C)nc21,amide
+120181,Modify the molecule O=S(=O)(c1ccc(-n2ccnc2)cc1)N1CCCC1 by removing a benzene_ring.,O=S(=O)(c1ccc(-n2ccnc2)cc1)N1CCCC1,benzene_ring
+9605,Please remove a benzene_ring from the molecule CCCCN(c1ccccc1)S(=O)(=O)c1cccc2nonc12.,CCCCN(c1ccccc1)S(=O)(=O)c1cccc2nonc12,benzene_ring
+175587,Please remove a benzene_ring from the molecule CCC[NH2+]Cc1ccccc1N(C)C[C@@H]1CCC[NH+]1C.,CCC[NH2+]Cc1ccccc1N(C)C[C@@H]1CCC[NH+]1C,benzene_ring
+218020,Remove a benzene_ring from the molecule O=C(NCCNC(=O)[C@@H]1CC(=O)N(c2cccc(Cl)c2)C1)c1ccc2[nH]ccc2c1.,O=C(NCCNC(=O)[C@@H]1CC(=O)N(c2cccc(Cl)c2)C1)c1ccc2[nH]ccc2c1,benzene_ring
+221715,Please remove a amide from the molecule CNC(=O)c1cccc(S(=O)(=O)N2CC[C@@]3(CCC[NH2+]C3)C2)c1.,CNC(=O)c1cccc(S(=O)(=O)N2CC[C@@]3(CCC[NH2+]C3)C2)c1,amide
+246192,Remove a amide from the molecule Cc1cc(N2CCN(C(=O)COc3cccc4ccccc34)CC2)ncn1.,Cc1cc(N2CCN(C(=O)COc3cccc4ccccc34)CC2)ncn1,amide
+186989,Please remove a benzene_ring from the molecule COC(=O)c1cccc(C(=O)O[C@H]2CCC[C@H]2OC)c1.,COC(=O)c1cccc(C(=O)O[C@H]2CCC[C@H]2OC)c1,benzene_ring
+166406,Please remove a amine from the molecule O=C(CNc1ccc(Cl)c(Br)c1)Nc1ccc(F)cc1.,O=C(CNc1ccc(Cl)c(Br)c1)Nc1ccc(F)cc1,amine
+76524,Modify the molecule Cc1nc2cc(NC(=O)C(=O)NCCCN3CCOCC3)ccc2o1 by removing a amide.,Cc1nc2cc(NC(=O)C(=O)NCCCN3CCOCC3)ccc2o1,amide
+33410,Modify the molecule CCOc1ccccc1CCC(=O)/N=c1\[nH]nc2cc(C)ccn12 by removing a benzene_ring.,CCOc1ccccc1CCC(=O)/N=c1\[nH]nc2cc(C)ccn12,benzene_ring
+222482,Remove a amine from the molecule CCOC(=O)c1nc2cnc(NC)nc2n(C)c1=O.,CCOC(=O)c1nc2cnc(NC)nc2n(C)c1=O,amine
+228301,Remove a benzene_ring from the molecule CC(=O)O[C@@H]1N=C(c2ccccc2F)c2cc(Cl)ccc2-n2c1cnc2C.,CC(=O)O[C@@H]1N=C(c2ccccc2F)c2cc(Cl)ccc2-n2c1cnc2C,benzene_ring
+212973,Modify the molecule C[C@H](O)c1cccc(OCc2ncc(-c3ccc(F)cc3)o2)c1 by removing a halo.,C[C@H](O)c1cccc(OCc2ncc(-c3ccc(F)cc3)o2)c1,halo
+203251,Please remove a halo from the molecule Cc1cc(F)cc(N[C@]2(CO)CCC[C@H](C)[C@@H]2C)c1.,Cc1cc(F)cc(N[C@]2(CO)CCC[C@H](C)[C@@H]2C)c1,halo
+187260,Remove a amine from the molecule N#Cc1ccc(CN2CCN(C(=O)CCNS(=O)(=O)c3ccc(F)c(Cl)c3)CC2)cc1.,N#Cc1ccc(CN2CCN(C(=O)CCNS(=O)(=O)c3ccc(F)c(Cl)c3)CC2)cc1,amine
+94184,Remove a halo from the molecule O=C(NCc1ccc(Oc2cccnc2)c(F)c1)c1cc(Cl)ccc1[N+](=O)[O-].,O=C(NCc1ccc(Oc2cccnc2)c(F)c1)c1cc(Cl)ccc1[N+](=O)[O-],halo
+35481,Remove a amide from the molecule COC(=O)[C@@H]1CCCC[C@@H]1NC(=O)CC(C)(C)c1ccccc1.,COC(=O)[C@@H]1CCCC[C@@H]1NC(=O)CC(C)(C)c1ccccc1,amide
+53669,Modify the molecule Cc1ccc(C(=O)N(C)C)cc1OC(=O)c1cc(F)ccc1NC(=O)[C@H]1C[C@H]1C by removing a amide.,Cc1ccc(C(=O)N(C)C)cc1OC(=O)c1cc(F)ccc1NC(=O)[C@H]1C[C@H]1C,amide
+72403,Modify the molecule CCn1c2ccccc2c2cc(NC(=O)c3ccnc(-n4cncn4)c3)ccc21 by removing a amide.,CCn1c2ccccc2c2cc(NC(=O)c3ccnc(-n4cncn4)c3)ccc21,amide
+122904,Please remove a amine from the molecule CCc1ccc(S(=O)(=O)N[C@H](C(=O)[O-])C(C)C)cc1.,CCc1ccc(S(=O)(=O)N[C@H](C(=O)[O-])C(C)C)cc1,amine
+125723,Modify the molecule O=C(N/N=C/c1cccs1)c1cccc(NC(=O)c2ccc(Cl)cc2)c1 by removing a halo.,O=C(N/N=C/c1cccs1)c1cccc(NC(=O)c2ccc(Cl)cc2)c1,halo
+28732,Please remove a benzene_ring from the molecule CC(=O)N[C@@H](CC(=O)N1CCCCCC1)c1ccc(Br)cc1.,CC(=O)N[C@@H](CC(=O)N1CCCCCC1)c1ccc(Br)cc1,benzene_ring
+129099,Remove a amine from the molecule COc1ncccc1CNCCC[NH+]1CCCC[C@H]1C.,COc1ncccc1CNCCC[NH+]1CCCC[C@H]1C,amine
+239491,Modify the molecule Cc1cc(C)c(CSc2nnc(-c3ccccc3)n2N)c(C)c1 by removing a benzene_ring.,Cc1cc(C)c(CSc2nnc(-c3ccccc3)n2N)c(C)c1,benzene_ring
+55537,Remove a benzene_ring from the molecule CCNC(=O)Nc1ccc(OCC(=O)NCc2cc(F)ccc2F)nc1.,CCNC(=O)Nc1ccc(OCC(=O)NCc2cc(F)ccc2F)nc1,benzene_ring
+154215,Modify the molecule CSc1ccc([C@H]2CC(=O)NC3=C2C(=O)C[C@@H](c2ccc(C)cc2)C3)cc1 by removing a amide.,CSc1ccc([C@H]2CC(=O)NC3=C2C(=O)C[C@@H](c2ccc(C)cc2)C3)cc1,amide
+188425,Remove a halo from the molecule COc1ccc([C@H](C)NC(=O)c2ccc(NC(=O)C3CC3)s2)cc1F.,COc1ccc([C@H](C)NC(=O)c2ccc(NC(=O)C3CC3)s2)cc1F,halo
+223158,Modify the molecule CC1CCN(C(=O)c2cc3c(-c4ccc(Cl)cc4)nn(C)c3s2)CC1 by removing a benzene_ring.,CC1CCN(C(=O)c2cc3c(-c4ccc(Cl)cc4)nn(C)c3s2)CC1,benzene_ring
+194165,Modify the molecule O=C(CCCNC(=O)N1CC[C@@H](C(=O)[O-])C1)NC1CC1 by removing a amide.,O=C(CCCNC(=O)N1CC[C@@H](C(=O)[O-])C1)NC1CC1,amide
+171785,Modify the molecule COc1ccc(-c2nn(-c3ccccc3C)cc2C[NH+](C)Cc2nccn2C)cc1F by removing a benzene_ring.,COc1ccc(-c2nn(-c3ccccc3C)cc2C[NH+](C)Cc2nccn2C)cc1F,benzene_ring
+63279,Modify the molecule CC1=N[C@H]2C(C(=O)N3CCC(N4c5[nH+]cccc5N[C@@H]4C4CCC4)CC3)=CC=CC2=C1C by removing a amide.,CC1=N[C@H]2C(C(=O)N3CCC(N4c5[nH+]cccc5N[C@@H]4C4CCC4)CC3)=CC=CC2=C1C,amide
+220667,Please remove a amine from the molecule C[C@@](O)(CO)CNc1ncc(Cl)cc1F.,C[C@@](O)(CO)CNc1ncc(Cl)cc1F,amine
+187659,Please remove a benzene_ring from the molecule COC(=O)C1(NC(=O)[C@@H](C)Oc2ccc(C)cc2)CCCC1.,COC(=O)C1(NC(=O)[C@@H](C)Oc2ccc(C)cc2)CCCC1,benzene_ring
+186332,Modify the molecule O[C@H]1CCC[C@@H]1C[C@@H]1CCCCO1 by removing a hydroxyl.,O[C@H]1CCC[C@@H]1C[C@@H]1CCCCO1,hydroxyl
+23306,Please remove a benzene_ring from the molecule CCn1cc(C(=O)N2CCN(C(=O)CCC3CCCCC3)CC2)c2nn(-c3ccccc3)c(=O)c-2c1.,CCn1cc(C(=O)N2CCN(C(=O)CCC3CCCCC3)CC2)c2nn(-c3ccccc3)c(=O)c-2c1,benzene_ring
+243403,Remove a benzene_ring from the molecule COC(=O)Cc1ccccc1NC(=O)C[C@H]1CCOc2ccccc21.,COC(=O)Cc1ccccc1NC(=O)C[C@H]1CCOc2ccccc21,benzene_ring
+198574,Modify the molecule C[C@]1([C@@H](Br)c2ccc(Cl)cc2Cl)CCCO1 by removing a benzene_ring.,C[C@]1([C@@H](Br)c2ccc(Cl)cc2Cl)CCCO1,benzene_ring
+66322,Modify the molecule Cc1cc(N[C@@H](C)C(=O)NCc2ccccc2)nc(-c2ccncc2)n1 by removing a benzene_ring.,Cc1cc(N[C@@H](C)C(=O)NCc2ccccc2)nc(-c2ccncc2)n1,benzene_ring
+20837,Please remove a hydroxyl from the molecule CC[C@](C)([C@@H](O)Cc1ccc(F)cc1Cl)N1CCOCC1.,CC[C@](C)([C@@H](O)Cc1ccc(F)cc1Cl)N1CCOCC1,hydroxyl
+104450,Please remove a benzene_ring from the molecule Cc1cc(C)cc([C@H](O)C[NH2+]C2(C(N)=O)CCCCC2)c1.,Cc1cc(C)cc([C@H](O)C[NH2+]C2(C(N)=O)CCCCC2)c1,benzene_ring
+86042,Remove a benzene_ring from the molecule Cc1ccc([C@@H](C)NC(=O)C(=O)Nc2cccc(-c3nccs3)c2)o1.,Cc1ccc([C@@H](C)NC(=O)C(=O)Nc2cccc(-c3nccs3)c2)o1,benzene_ring
+84208,Please remove a halo from the molecule C[C@@H](OC(=O)c1cnn2cc(Br)cnc12)c1cccnc1.,C[C@@H](OC(=O)c1cnn2cc(Br)cnc12)c1cccnc1,halo
+42866,Modify the molecule COCCN(Cc1ccsc1)S(=O)(=O)c1ccc(F)cc1F by removing a benzene_ring.,COCCN(Cc1ccsc1)S(=O)(=O)c1ccc(F)cc1F,benzene_ring
+160700,Remove a amide from the molecule Cc1c(CNC(=O)c2occc2Br)oc2ccccc12.,Cc1c(CNC(=O)c2occc2Br)oc2ccccc12,amide
+152682,Modify the molecule O=C1Nc2ccccc2/C1=C/c1cccc(C(=O)[O-])c1 by removing a amide.,O=C1Nc2ccccc2/C1=C/c1cccc(C(=O)[O-])c1,amide
+43700,Modify the molecule Cc1noc(C)c1S(=O)(=O)N(C)CC(=O)N1CCCCCCC1 by removing a amide.,Cc1noc(C)c1S(=O)(=O)N(C)CC(=O)N1CCCCCCC1,amide
+112433,Modify the molecule Cc1ccccc1/C=C1\Oc2c(ccc(O)c2CN2CCN(c3ccccc3)CC2)C1=O by removing a hydroxyl.,Cc1ccccc1/C=C1\Oc2c(ccc(O)c2CN2CCN(c3ccccc3)CC2)C1=O,hydroxyl
+60656,Modify the molecule CSc1ccc2c(c1)CC[NH+]([C@@H]1c3ccccc3C3(CC[NH2+]CC3)[C@H]1O)C2 by removing a hydroxyl.,CSc1ccc2c(c1)CC[NH+]([C@@H]1c3ccccc3C3(CC[NH2+]CC3)[C@H]1O)C2,hydroxyl
+49935,Modify the molecule Cn1c(=O)ccn(CC(=O)NCCc2ccc3c(c2)OCCO3)c1=O by removing a amide.,Cn1c(=O)ccn(CC(=O)NCCc2ccc3c(c2)OCCO3)c1=O,amide
+23441,Remove a benzene_ring from the molecule C[C@H](c1ccc(Cl)cc1)N(C)c1cncc(C[NH3+])n1.,C[C@H](c1ccc(Cl)cc1)N(C)c1cncc(C[NH3+])n1,benzene_ring
+35973,Modify the molecule CC[C@@H]1C[NH+]2CCCC[C@@H]2CN1Cc1ccc(F)cc1F by removing a halo.,CC[C@@H]1C[NH+]2CCCC[C@@H]2CN1Cc1ccc(F)cc1F,halo
+149616,Modify the molecule COC(=O)C[C@@H]1CCN(C(=O)Nc2cccc([N-]S(C)(=O)=O)c2)C1 by removing a benzene_ring.,COC(=O)C[C@@H]1CCN(C(=O)Nc2cccc([N-]S(C)(=O)=O)c2)C1,benzene_ring
+182159,Modify the molecule O=C(CCl)c1ncc(Cl)cc1F by removing a halo.,O=C(CCl)c1ncc(Cl)cc1F,halo
+30855,Remove a amide from the molecule Cc1cc2cc(C(=O)NNC(=O)c3ccc(Cl)nc3)oc2cc1C.,Cc1cc2cc(C(=O)NNC(=O)c3ccc(Cl)nc3)oc2cc1C,amide
+200853,Remove a amide from the molecule COc1ccc2c(c1)CCC[C@@H]2CC(=O)N1CCN([C@H](C#N)C(C)C)CC1.,COc1ccc2c(c1)CCC[C@@H]2CC(=O)N1CCN([C@H](C#N)C(C)C)CC1,amide
+97209,Please remove a benzene_ring from the molecule O=C(c1cccc2c1OCC2)N1CCC(c2[nH]ncc2-c2ccccc2)CC1.,O=C(c1cccc2c1OCC2)N1CCC(c2[nH]ncc2-c2ccccc2)CC1,benzene_ring
+180005,Remove a amide from the molecule C[C@@H]1CCC[C@H](NC(=O)C[NH+](CC(=O)N2CCCC2)C[C@@H]2CCCO2)[C@@H]1C.,C[C@@H]1CCC[C@H](NC(=O)C[NH+](CC(=O)N2CCCC2)C[C@@H]2CCCO2)[C@@H]1C,amide
+213873,Remove a nitrile from the molecule CC(C)CN(C)C(=O)N[C@H]1CCCN(c2ccc(C#N)cc2F)C1.,CC(C)CN(C)C(=O)N[C@H]1CCCN(c2ccc(C#N)cc2F)C1,nitrile
+224218,Modify the molecule Cc1c(C)n2c3c(=O)n(C)c(=O)n(C)c3nc2n1CC(=O)c1ccc(F)cc1 by removing a halo.,Cc1c(C)n2c3c(=O)n(C)c(=O)n(C)c3nc2n1CC(=O)c1ccc(F)cc1,halo
+127995,Please remove a amide from the molecule C=CCNC(=O)NC(=O)CN1CCOC[C@@H]1C1CC1.,C=CCNC(=O)NC(=O)CN1CCOC[C@@H]1C1CC1,amide
+234613,Please remove a amide from the molecule C[C@H](c1ccccc1)[NH+]1CC[C@H](NC(=O)c2ccc(Br)o2)C1.,C[C@H](c1ccccc1)[NH+]1CC[C@H](NC(=O)c2ccc(Br)o2)C1,amide
+223244,Remove a amide from the molecule Cn1cc[nH+]c1[C@@H]1[C@@H](C(=O)[O-])CC(=O)N1CCc1ccccc1F.,Cn1cc[nH+]c1[C@@H]1[C@@H](C(=O)[O-])CC(=O)N1CCc1ccccc1F,amide
+55426,Modify the molecule Cc1cccc(C)c1NC(=O)[C@H](C)Sc1nc2ccccc2c(=O)n1Cc1ccco1 by removing a benzene_ring.,Cc1cccc(C)c1NC(=O)[C@H](C)Sc1nc2ccccc2c(=O)n1Cc1ccco1,benzene_ring
+11816,Modify the molecule Cn1cc(N2CCC[C@H](Nc3nccc(OCc4ccccc4)n3)C2)cn1 by removing a amine.,Cn1cc(N2CCC[C@H](Nc3nccc(OCc4ccccc4)n3)C2)cn1,amine
+116650,Remove a amide from the molecule Cc1c(Br)cccc1CSCC(=O)NC1CC1.,Cc1c(Br)cccc1CSCC(=O)NC1CC1,amide
+36922,Remove a amide from the molecule Cc1cc(C)c(O)c(C(=O)Nc2cc(C(C)C)nn2-c2ncccn2)c1.,Cc1cc(C)c(O)c(C(=O)Nc2cc(C(C)C)nn2-c2ncccn2)c1,amide
+25342,Modify the molecule O=C1[C@H](Nc2ccc3c(c2)OCCCO3)CCCN1Cc1ccccc1 by removing a amide.,O=C1[C@H](Nc2ccc3c(c2)OCCCO3)CCCN1Cc1ccccc1,amide
+192154,Remove a benzene_ring from the molecule O=C(c1ccc(OC[C@@H]2CCCO2)cc1)N1CCCSc2ccccc21.,O=C(c1ccc(OC[C@@H]2CCCO2)cc1)N1CCCSc2ccccc21,benzene_ring
+69893,Please remove a halo from the molecule CC1=C[C@@H]([C@@H]2NN[C@H](S)N2/N=C/c2ccccc2F)N=N1.,CC1=C[C@@H]([C@@H]2NN[C@H](S)N2/N=C/c2ccccc2F)N=N1,halo
+124717,Remove a benzene_ring from the molecule C[C@H]([NH2+][C@@H](C)c1ccc2c(c1)OCCO2)C(=O)Nc1ccc(Cl)cc1.,C[C@H]([NH2+][C@@H](C)c1ccc2c(c1)OCCO2)C(=O)Nc1ccc(Cl)cc1,benzene_ring
+80188,Please remove a amide from the molecule Cc1ccc(C(=O)Nc2nnc(SCC(=O)c3ccccc3)s2)cc1.,Cc1ccc(C(=O)Nc2nnc(SCC(=O)c3ccccc3)s2)cc1,amide
+225863,Remove a amide from the molecule C[C@@H]1C[C@H]([NH3+])CN(CC(=O)Nc2cc(C(C)(C)C)no2)C1.,C[C@@H]1C[C@H]([NH3+])CN(CC(=O)Nc2cc(C(C)(C)C)no2)C1,amide
+78730,Please remove a amide from the molecule CC(=O)NC1(c2noc(CCC(=O)NC(C)(C)C)n2)CCCCCC1.,CC(=O)NC1(c2noc(CCC(=O)NC(C)(C)C)n2)CCCCCC1,amide
+80101,Please remove a amide from the molecule CCc1ccc(C(=O)N2CC[C@@H](C)[C@@H](O)C2)cc1.,CCc1ccc(C(=O)N2CC[C@@H](C)[C@@H](O)C2)cc1,amide
+106883,Modify the molecule CC[C@@H]([NH3+])c1cccc([C@@H]2CCc3cccnc32)c1 by removing a benzene_ring.,CC[C@@H]([NH3+])c1cccc([C@@H]2CCc3cccnc32)c1,benzene_ring
+58569,Remove a benzene_ring from the molecule COc1cc(S(=O)(=O)Oc2cc(C)ccc2C)ccc1Cl.,COc1cc(S(=O)(=O)Oc2cc(C)ccc2C)ccc1Cl,benzene_ring
+2551,Please remove a benzene_ring from the molecule C/[NH+]=C(/NCCc1cc(C)cc(C)c1)NCc1ncc(C)s1.,C/[NH+]=C(/NCCc1cc(C)cc(C)c1)NCc1ncc(C)s1,benzene_ring
+168764,Please remove a halo from the molecule CCCc1cc(NC(=O)C(=O)NC[C@@H](C)c2ccc(F)c(F)c2)n(C)n1.,CCCc1cc(NC(=O)C(=O)NC[C@@H](C)c2ccc(F)c(F)c2)n(C)n1,halo
+188237,Please remove a halo from the molecule C[C@@H]([NH2+]Cc1cccc2c1OCO2)c1ccc(Cl)s1.,C[C@@H]([NH2+]Cc1cccc2c1OCO2)c1ccc(Cl)s1,halo
+38356,Modify the molecule O=[N+]([O-])/C(=C/c1ccccc1[N+](=O)[O-])c1ccccc1 by removing a nitro.,O=[N+]([O-])/C(=C/c1ccccc1[N+](=O)[O-])c1ccccc1,nitro
+10445,Remove a benzene_ring from the molecule Cc1cc(-c2csc(CC(=O)N(C)C)n2)c(C)n1NC(=O)c1ccccc1.,Cc1cc(-c2csc(CC(=O)N(C)C)n2)c(C)n1NC(=O)c1ccccc1,benzene_ring
+34835,Remove a amine from the molecule CCC1(CC)CCN(c2[nH+]cc(N)cc2C)C1.,CCC1(CC)CCN(c2[nH+]cc(N)cc2C)C1,amine
+219095,Please remove a amide from the molecule C=C(C)C[C@@H]1CCC(=O)N1CCc1ccc(OC)cc1.,C=C(C)C[C@@H]1CCC(=O)N1CCc1ccc(OC)cc1,amide
+161901,Remove a benzene_ring from the molecule CSc1cccc(NC(=O)CSc2nc([O-])c3c(n2)CC[NH+](Cc2ccc(F)cc2)C3)c1.,CSc1cccc(NC(=O)CSc2nc([O-])c3c(n2)CC[NH+](Cc2ccc(F)cc2)C3)c1,benzene_ring
+241661,Modify the molecule O=[N+]([O-])c1ccc([O-])c(/C=[NH+]/Cc2ccccc2)c1 by removing a nitro.,O=[N+]([O-])c1ccc([O-])c(/C=[NH+]/Cc2ccccc2)c1,nitro
+169735,Please remove a amide from the molecule CCOC(=O)[C@H]1CCCN(C(=O)Cn2c(SC(F)F)nc3ccccc32)C1.,CCOC(=O)[C@H]1CCCN(C(=O)Cn2c(SC(F)F)nc3ccccc32)C1,amide
+205043,Remove a amide from the molecule CN(CCCNC(=O)CN1CC[S@](=O)C(C)(C)C1)c1ccccc1.,CN(CCCNC(=O)CN1CC[S@](=O)C(C)(C)C1)c1ccccc1,amide
+204308,Please remove a halo from the molecule N#C/C(=C/c1ccc(OCc2ccccc2F)cc1)C(=O)NCc1ccccc1.,N#C/C(=C/c1ccc(OCc2ccccc2F)cc1)C(=O)NCc1ccccc1,halo
+39316,Remove a halo from the molecule Cc1cc(CN2CC(=O)N[C@@H](C)C2=O)cc(C)c1F.,Cc1cc(CN2CC(=O)N[C@@H](C)C2=O)cc(C)c1F,halo
+12975,Please remove a halo from the molecule C[C@H](C(=O)NCCc1ccco1)n1c(=O)c(C(F)(F)F)nc2ccccc21.,C[C@H](C(=O)NCCc1ccco1)n1c(=O)c(C(F)(F)F)nc2ccccc21,halo
+67361,Please remove a benzene_ring from the molecule CN(C(=O)c1cc(F)cc(F)c1)C1CCCCCC1.,CN(C(=O)c1cc(F)cc(F)c1)C1CCCCCC1,benzene_ring
+222153,Please remove a amine from the molecule COc1ccc(NC(=O)c2cccc(C)c2)cc1N.,COc1ccc(NC(=O)c2cccc(C)c2)cc1N,amine
+222221,Please remove a amide from the molecule CN(C(=O)[C@H]1CCCN1C(=O)Cc1cccs1)C1CCS(=O)CC1.,CN(C(=O)[C@H]1CCCN1C(=O)Cc1cccs1)C1CCS(=O)CC1,amide
+42876,Modify the molecule COC[C@H](C)[NH+]1CCN(CC(=O)N[C@H]2CCCC[C@H]2C)CC1 by removing a amide.,COC[C@H](C)[NH+]1CCN(CC(=O)N[C@H]2CCCC[C@H]2C)CC1,amide
+237791,Modify the molecule Cc1cccc(OC(=O)c2cc(C3CC3)[nH]n2)c1 by removing a benzene_ring.,Cc1cccc(OC(=O)c2cc(C3CC3)[nH]n2)c1,benzene_ring
+242972,Modify the molecule CC[C@@H](C)NC(=O)CCNC(=O)N[C@@H](C)c1c(C)noc1C by removing a amide.,CC[C@@H](C)NC(=O)CCNC(=O)N[C@@H](C)c1c(C)noc1C,amide
+75382,Modify the molecule COc1ccccc1/C=C/C(=O)[C@@H](C#N)c1nnc2n1CCCCC2 by removing a nitrile.,COc1ccccc1/C=C/C(=O)[C@@H](C#N)c1nnc2n1CCCCC2,nitrile
+149371,Remove a benzene_ring from the molecule Cc1ccc(N(Cc2ccon2)Cc2ccco2)cc1.,Cc1ccc(N(Cc2ccon2)Cc2ccco2)cc1,benzene_ring
+243519,Modify the molecule C[NH2+][C@H](CCO)CN1CC[NH+]2CCCC[C@@H]2C1 by removing a hydroxyl.,C[NH2+][C@H](CCO)CN1CC[NH+]2CCCC[C@@H]2C1,hydroxyl
+229391,Remove a benzene_ring from the molecule CC(C)(C)[NH2+]C[C@H](c1ccccc1Cl)[C@@H]1CCS(=O)(=O)C1.,CC(C)(C)[NH2+]C[C@H](c1ccccc1Cl)[C@@H]1CCS(=O)(=O)C1,benzene_ring
+238167,Please remove a amine from the molecule COc1ccccc1NC(=O)[C@@H]1Sc2nnc(C)n2N[C@@H]1c1ccccc1.,COc1ccccc1NC(=O)[C@@H]1Sc2nnc(C)n2N[C@@H]1c1ccccc1,amine
+209745,Modify the molecule Cc1ccc(S(=O)(=O)Nc2cccc(C(=O)Nc3nc(-c4ccc5c(c4)OCO5)cs3)c2)cc1 by removing a benzene_ring.,Cc1ccc(S(=O)(=O)Nc2cccc(C(=O)Nc3nc(-c4ccc5c(c4)OCO5)cs3)c2)cc1,benzene_ring
+54609,Modify the molecule C[C@@H](Oc1ccc(Cl)cc1)C(=O)Nc1cccc(C(=O)N2CCCC2)c1 by removing a amide.,C[C@@H](Oc1ccc(Cl)cc1)C(=O)Nc1cccc(C(=O)N2CCCC2)c1,amide
+12211,Please remove a amide from the molecule CCCCN(CC)C(=O)[C@@H]1CC(=O)N(c2ccc(NC(C)=O)cc2)C1.,CCCCN(CC)C(=O)[C@@H]1CC(=O)N(c2ccc(NC(C)=O)cc2)C1,amide
+186778,Please remove a amine from the molecule CCOc1c(C)cc(S(=O)(=O)NC[C@](C)(O)C2CC2)cc1C.,CCOc1c(C)cc(S(=O)(=O)NC[C@](C)(O)C2CC2)cc1C,amine
+248523,Please remove a benzene_ring from the molecule CCN(CCO)C(=O)Nc1c(C)cccc1C.,CCN(CCO)C(=O)Nc1c(C)cccc1C,benzene_ring
+29165,Modify the molecule CC(C)Oc1ccc(C(=O)NCc2ccc(S(N)(=O)=O)cc2)cc1 by removing a amide.,CC(C)Oc1ccc(C(=O)NCc2ccc(S(N)(=O)=O)cc2)cc1,amide
+47558,Modify the molecule CCC(=O)NCc1ccccc1Cl by removing a halo.,CCC(=O)NCc1ccccc1Cl,halo
+198391,Remove a benzene_ring from the molecule Cc1ccc([C@H]2CN([C@@H]3CCOC3=O)CCO2)c(C)c1.,Cc1ccc([C@H]2CN([C@@H]3CCOC3=O)CCO2)c(C)c1,benzene_ring
+12742,Please remove a benzene_ring from the molecule CC(C)CCNC(=O)c1cccc(S(=O)(=O)N[C@@H]2CCCNC2=O)c1.,CC(C)CCNC(=O)c1cccc(S(=O)(=O)N[C@@H]2CCCNC2=O)c1,benzene_ring
+213447,Remove a benzene_ring from the molecule COc1cccc(N/N=C2/C(=N)[N-]N(C(C)=O)C2=N)c1.,COc1cccc(N/N=C2/C(=N)[N-]N(C(C)=O)C2=N)c1,benzene_ring
+69656,Modify the molecule CCC[NH2+][C@@]1(CO)CC[C@@H](N2C[C@H](C)OC[C@@H]2CC)C1 by removing a hydroxyl.,CCC[NH2+][C@@]1(CO)CC[C@@H](N2C[C@H](C)OC[C@@H]2CC)C1,hydroxyl
+220075,Please remove a amide from the molecule CN(Cc1ccc(Cl)nc1)C(=O)[C@@H]1C[C@H]2CC[C@@H]1O2.,CN(Cc1ccc(Cl)nc1)C(=O)[C@@H]1C[C@H]2CC[C@@H]1O2,amide
+144863,Remove a amide from the molecule C#CCN1CCC(C(=O)N2CCC[C@@H]2c2ccc(C(C)C)cc2)CC1.,C#CCN1CCC(C(=O)N2CCC[C@@H]2c2ccc(C(C)C)cc2)CC1,amide
+206921,Please remove a amide from the molecule CC[C@H](C)C[C@H](C)NC(=O)N[C@@H]1CCN(c2cnn(C)c2)C1=O.,CC[C@H](C)C[C@H](C)NC(=O)N[C@@H]1CCN(c2cnn(C)c2)C1=O,amide
+120091,Please remove a hydroxyl from the molecule C[NH+]1CCC(CCNC(=O)N[C@@H]2CCC[C@@H]2CO)CC1.,C[NH+]1CCC(CCNC(=O)N[C@@H]2CCC[C@@H]2CO)CC1,hydroxyl
+220800,Remove a benzene_ring from the molecule Cc1ccn(C/C=C/c2ccccc2)c(=O)c1.,Cc1ccn(C/C=C/c2ccccc2)c(=O)c1,benzene_ring
+113902,Remove a benzene_ring from the molecule Cc1ccc([C@@H](NC(=O)C[C@H](NC(N)=O)c2ccccc2)c2ccccc2)cc1C.,Cc1ccc([C@@H](NC(=O)C[C@H](NC(N)=O)c2ccccc2)c2ccccc2)cc1C,benzene_ring
+184331,Please remove a amide from the molecule COC(=O)c1ccc(CNC(=O)c2cn(C[C@@H]3CCCO3)nn2)cc1.,COC(=O)c1ccc(CNC(=O)c2cn(C[C@@H]3CCCO3)nn2)cc1,amide
+96495,Please remove a amine from the molecule CCOC(=O)C1CCC(Nc2ccc(Cn3cccn3)cc2)CC1.,CCOC(=O)C1CCC(Nc2ccc(Cn3cccn3)cc2)CC1,amine
+77395,Remove a benzene_ring from the molecule COc1ccc(OC)c([C@H](C)NC(=O)C2CCOCC2)c1.,COc1ccc(OC)c([C@H](C)NC(=O)C2CCOCC2)c1,benzene_ring
+58080,Remove a halo from the molecule CC[NH+](Cc1ccccc1Cl)Cn1nc(-c2ccncc2)n(C2CC2)c1=S.,CC[NH+](Cc1ccccc1Cl)Cn1nc(-c2ccncc2)n(C2CC2)c1=S,halo
+53670,Modify the molecule Cc1n[nH]c(C)c1CNC(=O)c1ccnc(OC(C)(C)C)c1 by removing a amide.,Cc1n[nH]c(C)c1CNC(=O)c1ccnc(OC(C)(C)C)c1,amide
+118883,Remove a benzene_ring from the molecule CCOC(=O)[C@H]1CC(=O)N(c2ccc(CN3CCOCC3)cc2)C1.,CCOC(=O)[C@H]1CC(=O)N(c2ccc(CN3CCOCC3)cc2)C1,benzene_ring
+108219,Remove a benzene_ring from the molecule Cc1ccccc1OCC(=O)N/N=C/c1ccc(N2CCCCCC2)o1.,Cc1ccccc1OCC(=O)N/N=C/c1ccc(N2CCCCCC2)o1,benzene_ring
+133024,Please remove a halo from the molecule Cn1cc(I)c(=O)n(CC(=O)NC[C@H]2CCCO2)c1=O.,Cn1cc(I)c(=O)n(CC(=O)NC[C@H]2CCCO2)c1=O,halo
+237761,Modify the molecule COc1ccc(C[NH+]2CC[C@]3(CCC[NH+](CC4CCC4)C3)C2)cc1 by removing a benzene_ring.,COc1ccc(C[NH+]2CC[C@]3(CCC[NH+](CC4CCC4)C3)C2)cc1,benzene_ring
+213747,Please remove a benzene_ring from the molecule CC(C)Sc1ccc([C@@H](C)NC(=O)[C@@H]2COCCO2)cc1.,CC(C)Sc1ccc([C@@H](C)NC(=O)[C@@H]2COCCO2)cc1,benzene_ring
+59060,Remove a hydroxyl from the molecule CC[NH2+][C@]1(CO)CC[C@@H](Sc2ccc(C(C)(C)C)cc2)C1.,CC[NH2+][C@]1(CO)CC[C@@H](Sc2ccc(C(C)(C)C)cc2)C1,hydroxyl
+132817,Remove a halo from the molecule O=C1N=C2C=C(c3ccccc3)S[C@H]2C(=O)N1c1ccc(Cl)cc1.,O=C1N=C2C=C(c3ccccc3)S[C@H]2C(=O)N1c1ccc(Cl)cc1,halo
+41166,Modify the molecule CS(=O)(=O)N1CCC[C@@H](CN2CCCc3c(F)cccc32)C1 by removing a halo.,CS(=O)(=O)N1CCC[C@@H](CN2CCCc3c(F)cccc32)C1,halo
+230244,Remove a benzene_ring from the molecule O=C(Nc1ccc(N2CCCN(c3ccc(Cl)nn3)CC2)c(C(=O)[O-])c1)c1ccc(F)cc1.,O=C(Nc1ccc(N2CCCN(c3ccc(Cl)nn3)CC2)c(C(=O)[O-])c1)c1ccc(F)cc1,benzene_ring
+43443,Modify the molecule C[C@H]1CCC[C@@H](CCNC(=O)c2ccccc2Cn2cncn2)C1 by removing a amide.,C[C@H]1CCC[C@@H](CCNC(=O)c2ccccc2Cn2cncn2)C1,amide
+13961,Please remove a amide from the molecule Cc1c(C[NH+]2CCn3nc(C(=O)NCCO)cc3C2)[nH]c2ccc(F)cc12.,Cc1c(C[NH+]2CCn3nc(C(=O)NCCO)cc3C2)[nH]c2ccc(F)cc12,amide
+51190,Remove a amide from the molecule CS(=O)(=O)N1CCN(C(=O)c2cn(Cc3ccccc3)c3ccccc23)CC1.,CS(=O)(=O)N1CCN(C(=O)c2cn(Cc3ccccc3)c3ccccc23)CC1,amide
+162615,Modify the molecule COC(=O)[C@@H]1CCC[C@@H]1NC(=O)c1cccc(Nc2cnn(C)c2)c1 by removing a amide.,COC(=O)[C@@H]1CCC[C@@H]1NC(=O)c1cccc(Nc2cnn(C)c2)c1,amide
+162780,Remove a hydroxyl from the molecule C[C@H]1CCN(C(=O)NC[C@@H]2CCC[NH+](C)[C@@H]2c2cccs2)C[C@H]1O.,C[C@H]1CCN(C(=O)NC[C@@H]2CCC[NH+](C)[C@@H]2c2cccs2)C[C@H]1O,hydroxyl
+178657,Remove a halo from the molecule O=C([O-])C1CCN(C(=O)COc2ccc(Cl)cc2Cl)CC1.,O=C([O-])C1CCN(C(=O)COc2ccc(Cl)cc2Cl)CC1,halo
+248776,Please remove a amide from the molecule CCCN1C(=O)S[C@H](Nc2ccccc2)C1=O.,CCCN1C(=O)S[C@H](Nc2ccccc2)C1=O,amide
+69433,Please remove a amide from the molecule CCn1c(SCC(=O)Nc2cccc3cn[nH]c23)nnc1-c1cccc(C)c1.,CCn1c(SCC(=O)Nc2cccc3cn[nH]c23)nnc1-c1cccc(C)c1,amide
+18715,Please remove a benzene_ring from the molecule Cc1ccccc1Cc1nnc(NC(=O)C[C@H]2C[NH2+]CCO2)s1.,Cc1ccccc1Cc1nnc(NC(=O)C[C@H]2C[NH2+]CCO2)s1,benzene_ring
+147308,Please remove a halo from the molecule CC[NH+](CC)CCn1c([C@H](C)Cl)nc2cnccc21.,CC[NH+](CC)CCn1c([C@H](C)Cl)nc2cnccc21,halo
+160990,Remove a benzene_ring from the molecule CCN(Cc1ccccc1)C1(C[NH3+])CCCC1.,CCN(Cc1ccccc1)C1(C[NH3+])CCCC1,benzene_ring
+54182,Remove a amide from the molecule CC(C)Cn1c(C[C@H]2CCN(C(=O)C(C)(C)C)C2)nc2cccnc21.,CC(C)Cn1c(C[C@H]2CCN(C(=O)C(C)(C)C)C2)nc2cccnc21,amide
+158845,Modify the molecule Cc1cccc2nc(C(=O)O[C@@H](C)C(=O)Nc3cccc(C(F)(F)F)c3)cn12 by removing a amide.,Cc1cccc2nc(C(=O)O[C@@H](C)C(=O)Nc3cccc(C(F)(F)F)c3)cn12,amide
+129116,Please remove a amide from the molecule CC(C)N(C[C@H]1C[C@@H]1C)C(=O)Cc1c(F)cccc1F.,CC(C)N(C[C@H]1C[C@@H]1C)C(=O)Cc1c(F)cccc1F,amide
+99354,Please remove a benzene_ring from the molecule Cc1cc(NC(=O)CNc2ccc(C(=O)N(C)C)c(C)c2)n(C(C)(C)C)n1.,Cc1cc(NC(=O)CNc2ccc(C(=O)N(C)C)c(C)c2)n(C(C)(C)C)n1,benzene_ring
+198542,Modify the molecule CN(CCc1ccccn1)C(=O)c1ccccc1Br by removing a amide.,CN(CCc1ccccn1)C(=O)c1ccccc1Br,amide
+176596,Modify the molecule CC1=C(c2ccccc2)C(=O)O[C@@H]2C[C@@H](Cl)CC[C@@H]12 by removing a halo.,CC1=C(c2ccccc2)C(=O)O[C@@H]2C[C@@H](Cl)CC[C@@H]12,halo
+9739,Please remove a benzene_ring from the molecule CC(C)CN(C(=O)Cc1ccccc1Cl)c1c(N)n(CC(C)C)c(=O)[nH]c1=O.,CC(C)CN(C(=O)Cc1ccccc1Cl)c1c(N)n(CC(C)C)c(=O)[nH]c1=O,benzene_ring
+156694,Please remove a benzene_ring from the molecule Cc1ccsc1[C@H](O)c1ccccc1C1CC1.,Cc1ccsc1[C@H](O)c1ccccc1C1CC1,benzene_ring
+19003,Modify the molecule CC[NH+](Cc1cccc(C)n1)Cc1cc(C(=O)NN)no1 by removing a amine.,CC[NH+](Cc1cccc(C)n1)Cc1cc(C(=O)NN)no1,amine
+148773,Please remove a amide from the molecule CCN(C(=O)c1ccc(-n2nc(C)nc2C)cc1)C1CCCCC1.,CCN(C(=O)c1ccc(-n2nc(C)nc2C)cc1)C1CCCCC1,amide
+234166,Please remove a benzene_ring from the molecule Cc1ccc(N2C[C@@H](C(=O)NCCS(=O)(=O)N3CCN(c4ccccc4)CC3)CC2=O)cc1.,Cc1ccc(N2C[C@@H](C(=O)NCCS(=O)(=O)N3CCN(c4ccccc4)CC3)CC2=O)cc1,benzene_ring
+199887,Remove a nitrile from the molecule CCn1ncc([C@H]2C(C#N)=C(N)OC3=C2C(=O)CCC3)c1C.,CCn1ncc([C@H]2C(C#N)=C(N)OC3=C2C(=O)CCC3)c1C,nitrile
+224389,Remove a amide from the molecule CC(C)[NH+]1CCC(C(=O)Nc2nnc(C(F)(F)F)s2)CC1.,CC(C)[NH+]1CCC(C(=O)Nc2nnc(C(F)(F)F)s2)CC1,amide
+213681,Modify the molecule Cc1cc2c(cc1C)O[C@@H](C(=O)NCc1nnc3ccccn13)C2 by removing a amide.,Cc1cc2c(cc1C)O[C@@H](C(=O)NCc1nnc3ccccn13)C2,amide
+37666,Modify the molecule COC(=O)[C@H](C)NC(=O)c1cnn(-c2cccc(Cl)c2)c1 by removing a benzene_ring.,COC(=O)[C@H](C)NC(=O)c1cnn(-c2cccc(Cl)c2)c1,benzene_ring
+167226,Modify the molecule N/C(=N\OC(=O)c1ccc2ccccc2c1)c1ccccc1Cl by removing a amine.,N/C(=N\OC(=O)c1ccc2ccccc2c1)c1ccccc1Cl,amine
+18723,Remove a benzene_ring from the molecule COc1ccccc1CNC(=O)N(C)Cc1nnc(C2CC2)n1C.,COc1ccccc1CNC(=O)N(C)Cc1nnc(C2CC2)n1C,benzene_ring
+235545,Please remove a halo from the molecule CC[C@@](C)([C@@H](N)c1cccc(Cl)c1)[NH+](C)C.,CC[C@@](C)([C@@H](N)c1cccc(Cl)c1)[NH+](C)C,halo
+11017,Remove a hydroxyl from the molecule CCOC(=O)c1ccc(C[NH+]2CCCC[C@H]2[C@H](O)CC)o1.,CCOC(=O)c1ccc(C[NH+]2CCCC[C@H]2[C@H](O)CC)o1,hydroxyl
+226519,Please remove a halo from the molecule CCC1=NN(C(=O)c2ccc(F)cc2)[C@@](O)(C(F)(F)F)C1.,CCC1=NN(C(=O)c2ccc(F)cc2)[C@@](O)(C(F)(F)F)C1,halo
+25694,Modify the molecule O=C([C@@H]1C[C@@H]1[N+](=O)[O-])N1CCS(=O)(=O)C[C@H]1c1ccccc1 by removing a benzene_ring.,O=C([C@@H]1C[C@@H]1[N+](=O)[O-])N1CCS(=O)(=O)C[C@H]1c1ccccc1,benzene_ring
+163397,Modify the molecule CC1CCC(N(C)C(=O)CS(=O)(=O)[C@@H](C)C(C)C)CC1 by removing a amide.,CC1CCC(N(C)C(=O)CS(=O)(=O)[C@@H](C)C(C)C)CC1,amide
+62192,Please remove a amine from the molecule CNC(=O)c1cccnc1N[C@@H]1C[C@H]2CC[C@@H]1O2.,CNC(=O)c1cccnc1N[C@@H]1C[C@H]2CC[C@@H]1O2,amine
+191671,Please remove a benzene_ring from the molecule C(=N/Nc1nn2cnnc2c2ccccc12)\c1ccc(OCc2ccccc2)cc1.,C(=N/Nc1nn2cnnc2c2ccccc12)\c1ccc(OCc2ccccc2)cc1,benzene_ring
+105992,Modify the molecule CC(C)(C)[C@H](O)CNC(=O)NC[C@H](c1ccc(Cl)cc1)n1cccn1 by removing a hydroxyl.,CC(C)(C)[C@H](O)CNC(=O)NC[C@H](c1ccc(Cl)cc1)n1cccn1,hydroxyl
+162680,Modify the molecule Cc1cc(C)nc(N2CCC(Oc3ccnc(C(N)=O)c3)CC2)n1 by removing a amide.,Cc1cc(C)nc(N2CCC(Oc3ccnc(C(N)=O)c3)CC2)n1,amide
+75321,Please remove a hydroxyl from the molecule C/C(=C1\C(=O)NC(=O)N=C1[O-])c1cc(C)ccc1O.,C/C(=C1\C(=O)NC(=O)N=C1[O-])c1cc(C)ccc1O,hydroxyl
+31465,Modify the molecule CC(=O)c1cccc(S(=O)(=O)Nc2cc(Cl)ccc2F)c1 by removing a amine.,CC(=O)c1cccc(S(=O)(=O)Nc2cc(Cl)ccc2F)c1,amine
+115675,Remove a benzene_ring from the molecule Cc1ccc(NC(=O)c2ccccc2NC(=O)c2cc(C)n(C)n2)c(C(=O)c2ccccc2)c1.,Cc1ccc(NC(=O)c2ccccc2NC(=O)c2cc(C)n(C)n2)c(C(=O)c2ccccc2)c1,benzene_ring
+38832,Modify the molecule CCN(Cc1ccccn1)C(=O)[C@H]1C[C@H]1c1ccc(Cl)cc1 by removing a halo.,CCN(Cc1ccccn1)C(=O)[C@H]1C[C@H]1c1ccc(Cl)cc1,halo
+161588,Remove a halo from the molecule Cc1ccc([C@H](C)[NH+]2CCCC[C@@H]2[C@@H]2CCCN2)cc1F.,Cc1ccc([C@H](C)[NH+]2CCCC[C@@H]2[C@@H]2CCCN2)cc1F,halo
+163986,Modify the molecule Cc1cc([C@H]2C(C#N)=C(N)SC(=N)[C@H]2C#N)c(C)s1 by removing a amine.,Cc1cc([C@H]2C(C#N)=C(N)SC(=N)[C@H]2C#N)c(C)s1,amine
+190026,Please remove a benzene_ring from the molecule C[C@@H](c1cccc(C(F)(F)F)c1)[NH+]1CC[C@@H](C(=O)[O-])[C@H]1C.,C[C@@H](c1cccc(C(F)(F)F)c1)[NH+]1CC[C@@H](C(=O)[O-])[C@H]1C,benzene_ring
+246940,Please remove a hydroxyl from the molecule CC1CC[NH+]([C@@H](C)CNC(=O)NC[C@@H](C)C[C@@H](C)O)CC1.,CC1CC[NH+]([C@@H](C)CNC(=O)NC[C@@H](C)C[C@@H](C)O)CC1,hydroxyl
+157663,Modify the molecule CC[C@@H](NC(=O)[C@@H]1Cc2cc(C)c(C)cc2O1)c1nc2ccccc2[nH]1 by removing a amide.,CC[C@@H](NC(=O)[C@@H]1Cc2cc(C)c(C)cc2O1)c1nc2ccccc2[nH]1,amide
+248167,Modify the molecule Cc1cccc(C(C)C)c1NC(=O)c1ccc2c([O-])n(C)c(=S)nc2c1 by removing a amide.,Cc1cccc(C(C)C)c1NC(=O)c1ccc2c([O-])n(C)c(=S)nc2c1,amide
+235145,Modify the molecule O=S1(=O)C[C@@H](OS(=O)(=O)[O-])[C@H](c2ccccc2)C1 by removing a benzene_ring.,O=S1(=O)C[C@@H](OS(=O)(=O)[O-])[C@H](c2ccccc2)C1,benzene_ring
+127787,Remove a amide from the molecule C[C@H]1CCCCN1C(=O)CNC(=O)CNC(=O)c1ccc(Cl)cc1Cl.,C[C@H]1CCCCN1C(=O)CNC(=O)CNC(=O)c1ccc(Cl)cc1Cl,amide
+174180,Modify the molecule CC[C@@H](c1ccccc1)[S@@](=O)Cc1coc(-c2cccs2)n1 by removing a benzene_ring.,CC[C@@H](c1ccccc1)[S@@](=O)Cc1coc(-c2cccs2)n1,benzene_ring
+7470,Remove a amide from the molecule CC(=O)N/C(=C/c1ccccc1)C(=O)Nc1cccc(C(C)=O)c1.,CC(=O)N/C(=C/c1ccccc1)C(=O)Nc1cccc(C(C)=O)c1,amide
+55190,Modify the molecule Cc1cc(C)cc(C(=O)NCC(=O)NCc2cnn(-c3ccccc3)c2)c1 by removing a benzene_ring.,Cc1cc(C)cc(C(=O)NCC(=O)NCc2cnn(-c3ccccc3)c2)c1,benzene_ring
+209595,Please remove a amine from the molecule Cc1c(NC(=O)c2ccccc2)cccc1N[C@H](C)C(=O)Nc1cccc(C#N)c1.,Cc1c(NC(=O)c2ccccc2)cccc1N[C@H](C)C(=O)Nc1cccc(C#N)c1,amine
+163836,Modify the molecule Cc1cc(Br)ccc1OCCCN1CC[NH2+]CC1 by removing a halo.,Cc1cc(Br)ccc1OCCCN1CC[NH2+]CC1,halo
+158002,Remove a amide from the molecule CC(C)[C@@H](NC(=O)CCl)c1ccccc1.,CC(C)[C@@H](NC(=O)CCl)c1ccccc1,amide
+60563,Remove a amide from the molecule C[C@H](c1cccs1)N(C)C(=O)[C@@H]1CC[C@H](C[NH3+])O1.,C[C@H](c1cccs1)N(C)C(=O)[C@@H]1CC[C@H](C[NH3+])O1,amide
+232031,Modify the molecule Cc1ccc(-c2ccc(=O)[nH]n2)cc1S(=O)(=O)N(C)c1ccccc1 by removing a benzene_ring.,Cc1ccc(-c2ccc(=O)[nH]n2)cc1S(=O)(=O)N(C)c1ccccc1,benzene_ring
+214555,Modify the molecule O=C(OCCN1C(=O)c2ccccc2C1=O)c1ccccc1C(=O)c1ccccc1 by removing a amide.,O=C(OCCN1C(=O)c2ccccc2C1=O)c1ccccc1C(=O)c1ccccc1,amide
+169319,Modify the molecule COc1ccc(/C=N/NC(=O)C(C)(C)O)cc1OC(C)C by removing a hydroxyl.,COc1ccc(/C=N/NC(=O)C(C)(C)O)cc1OC(C)C,hydroxyl
+184414,Remove a benzene_ring from the molecule CCOc1cc(NC(=O)c2ccc(F)c(COC)c2)ccc1OC.,CCOc1cc(NC(=O)c2ccc(F)c(COC)c2)ccc1OC,benzene_ring
+98413,Remove a benzene_ring from the molecule CCc1ccc([C@H](C)CC(=O)N2CCC[C@H](NC(=O)C(C)C)C2)cc1.,CCc1ccc([C@H](C)CC(=O)N2CCC[C@H](NC(=O)C(C)C)C2)cc1,benzene_ring
+244557,Please remove a nitrile from the molecule C[C@H](C#N)CNC(=O)c1cccc(SCC#N)c1.,C[C@H](C#N)CNC(=O)c1cccc(SCC#N)c1,nitrile
+121984,Remove a benzene_ring from the molecule CC[S@](=O)c1ccccc1C(=O)N[C@@H](c1ccccc1)c1ccc(OC)cc1.,CC[S@](=O)c1ccccc1C(=O)N[C@@H](c1ccccc1)c1ccc(OC)cc1,benzene_ring
+27751,Remove a hydroxyl from the molecule COc1cc(Cl)ccc1/N=C/c1cc(Br)ccc1O.,COc1cc(Cl)ccc1/N=C/c1cc(Br)ccc1O,hydroxyl
+135894,Modify the molecule CC(=O)NCc1ccc(C(=O)N[C@@H]2C[C@@H]3CCCc4cccc2c43)s1 by removing a amide.,CC(=O)NCc1ccc(C(=O)N[C@@H]2C[C@@H]3CCCc4cccc2c43)s1,amide
+68516,Remove a amide from the molecule O=C(Cn1c(CCNC(=O)c2cccc(Br)c2)nc2ccccc21)c1ccccc1.,O=C(Cn1c(CCNC(=O)c2cccc(Br)c2)nc2ccccc21)c1ccccc1,amide
+147159,Modify the molecule Cc1ccc(C)c(NC(=O)CN2C(=O)CC3(CCCCC3)C2=O)c1 by removing a benzene_ring.,Cc1ccc(C)c(NC(=O)CN2C(=O)CC3(CCCCC3)C2=O)c1,benzene_ring
+57131,Please remove a amide from the molecule Cc1cccn2c(=O)c(C(=O)Nc3ccc4c(c3)CC(=O)N4)cnc12.,Cc1cccn2c(=O)c(C(=O)Nc3ccc4c(c3)CC(=O)N4)cnc12,amide
+101873,Modify the molecule CCc1ocnc1C(=O)N[C@H](C)Cc1c(Cl)cccc1Cl by removing a halo.,CCc1ocnc1C(=O)N[C@H](C)Cc1c(Cl)cccc1Cl,halo
+211541,Modify the molecule CC[C@H](C)NC(=O)[C@@H]1CCCCN1S(=O)(=O)c1ccccc1 by removing a benzene_ring.,CC[C@H](C)NC(=O)[C@@H]1CCCCN1S(=O)(=O)c1ccccc1,benzene_ring
+94853,Remove a amide from the molecule O=C(NC(=S)Nc1ccccc1N1CCCC1)c1ccc(-c2cccc([N+](=O)[O-])c2)o1.,O=C(NC(=S)Nc1ccccc1N1CCCC1)c1ccc(-c2cccc([N+](=O)[O-])c2)o1,amide
+90652,Modify the molecule CCNC(=O)N1CC[C@@H](NC(=O)N[C@@H]2CCCc3ccc(F)cc32)C1 by removing a halo.,CCNC(=O)N1CC[C@@H](NC(=O)N[C@@H]2CCCc3ccc(F)cc32)C1,halo
+166381,Modify the molecule Cc1ccc([N+](=O)[O-])cc1NC(=O)[C@@H](C)N1CCN(C(=O)N(C)C)CC1 by removing a benzene_ring.,Cc1ccc([N+](=O)[O-])cc1NC(=O)[C@@H](C)N1CCN(C(=O)N(C)C)CC1,benzene_ring
+100993,Modify the molecule C[C@@H]1CN(C(=O)c2cc(S(C)(=O)=O)c(Cl)cc2Cl)C[C@@H](C)O1 by removing a halo.,C[C@@H]1CN(C(=O)c2cc(S(C)(=O)=O)c(Cl)cc2Cl)C[C@@H](C)O1,halo
+1574,Remove a benzene_ring from the molecule CCn1cnnc1SCC(=O)c1ccc(OC)cc1OC.,CCn1cnnc1SCC(=O)c1ccc(OC)cc1OC,benzene_ring
+178706,Remove a amide from the molecule CCCc1ncc(C(=O)N(C)[C@@H](C)CSCC)s1.,CCCc1ncc(C(=O)N(C)[C@@H](C)CSCC)s1,amide
+43479,Modify the molecule C[C@@H](NC(=O)Nc1ccc(OCCC(N)=O)cc1)c1ccc(Cl)cc1 by removing a benzene_ring.,C[C@@H](NC(=O)Nc1ccc(OCCC(N)=O)cc1)c1ccc(Cl)cc1,benzene_ring
+87680,Please remove a amide from the molecule C[C@@H](SCC(=O)N1CCO[C@H]2CCCC[C@@H]21)c1cccs1.,C[C@@H](SCC(=O)N1CCO[C@H]2CCCC[C@@H]21)c1cccs1,amide
+218129,Remove a benzene_ring from the molecule COc1ccc([C@H](C(=O)[O-])c2ccc([O-])nn2)cc1.,COc1ccc([C@H](C(=O)[O-])c2ccc([O-])nn2)cc1,benzene_ring
+66432,Modify the molecule Cc1n[nH]c(C(c2ccccc2)c2ccccc2)c1C(=O)NN by removing a amine.,Cc1n[nH]c(C(c2ccccc2)c2ccccc2)c1C(=O)NN,amine
+88368,Remove a amine from the molecule COC(=O)c1coc(S(=O)(=O)Nc2c(C)n[nH]c2C)c1.,COC(=O)c1coc(S(=O)(=O)Nc2c(C)n[nH]c2C)c1,amine
+193335,Remove a benzene_ring from the molecule C[C@H]1C[C@H](C)C[NH+](Cc2ccccc2CNC(=O)c2ccc(Cl)cc2[N+](=O)[O-])C1.,C[C@H]1C[C@H](C)C[NH+](Cc2ccccc2CNC(=O)c2ccc(Cl)cc2[N+](=O)[O-])C1,benzene_ring
+110601,Modify the molecule CCOc1ccccc1/C=C/C(=O)N1CCc2sccc2C1 by removing a amide.,CCOc1ccccc1/C=C/C(=O)N1CCc2sccc2C1,amide
+22019,Please remove a amide from the molecule CC(=O)c1ccc(N2CCN(C(=O)c3cccs3)CC2)c(F)c1.,CC(=O)c1ccc(N2CCN(C(=O)c3cccs3)CC2)c(F)c1,amide
+69119,Please remove a benzene_ring from the molecule Cc1ccc(C(=O)NCC(=O)N2CCC(C(=O)Nc3ccccc3)CC2)cc1C.,Cc1ccc(C(=O)NCC(=O)N2CCC(C(=O)Nc3ccccc3)CC2)cc1C,benzene_ring
+117552,Please remove a hydroxyl from the molecule CCN(CC1CC1)c1ccc([C@@H](C)[NH3+])c(O)c1.,CCN(CC1CC1)c1ccc([C@@H](C)[NH3+])c(O)c1,hydroxyl
+94550,Modify the molecule Cc1cccnc1C[NH+](C)Cc1ccc(F)cc1Cl by removing a benzene_ring.,Cc1cccnc1C[NH+](C)Cc1ccc(F)cc1Cl,benzene_ring
+187211,Modify the molecule CC[C@H]1CCCC[C@]12CC[NH2+]C[C@@H]2c1ccccc1F by removing a halo.,CC[C@H]1CCCC[C@]12CC[NH2+]C[C@@H]2c1ccccc1F,halo
+55523,Remove a amide from the molecule CN(C)C(=O)CCNC(=O)C(=O)Nc1ccnn1C1CCCCC1.,CN(C)C(=O)CCNC(=O)C(=O)Nc1ccnn1C1CCCCC1,amide
+170399,Remove a halo from the molecule COc1ccc([C@@H]2[C@@H](C(=O)Nc3cc(Cl)ccc3OC)c3ccccc3C(=O)N2C)cc1.,COc1ccc([C@@H]2[C@@H](C(=O)Nc3cc(Cl)ccc3OC)c3ccccc3C(=O)N2C)cc1,halo
+208777,Modify the molecule COc1ccc(OC)c(-c2ccc(SCC(=O)NC(C)C)nn2)c1 by removing a benzene_ring.,COc1ccc(OC)c(-c2ccc(SCC(=O)NC(C)C)nn2)c1,benzene_ring
+104192,Modify the molecule [NH3+][C@H]1CCC[C@H](Nc2cccc(-c3cnco3)c2)C1 by removing a benzene_ring.,[NH3+][C@H]1CCC[C@H](Nc2cccc(-c3cnco3)c2)C1,benzene_ring
+247037,Modify the molecule CCOc1cc(NC2C[C@H](C)O[C@@H](C)C2)ccc1C by removing a benzene_ring.,CCOc1cc(NC2C[C@H](C)O[C@@H](C)C2)ccc1C,benzene_ring
+73247,Please remove a hydroxyl from the molecule C[C@H](CCNC(=O)OCCO)c1ccccc1.,C[C@H](CCNC(=O)OCCO)c1ccccc1,hydroxyl
+125238,Remove a benzene_ring from the molecule COc1ccc(Cn2c(CNC(=O)c3ccc(OC)cc3)nc3cccnc32)cc1.,COc1ccc(Cn2c(CNC(=O)c3ccc(OC)cc3)nc3cccnc32)cc1,benzene_ring
+232573,Modify the molecule COc1ccc(S(=O)(=O)NCc2nc3nc(C)cc(C)n3n2)cc1 by removing a benzene_ring.,COc1ccc(S(=O)(=O)NCc2nc3nc(C)cc(C)n3n2)cc1,benzene_ring
+244818,Modify the molecule CC(C)C[C@H]([NH2+][C@@H]1CSCC(C)(C)C1)c1ccccc1 by removing a benzene_ring.,CC(C)C[C@H]([NH2+][C@@H]1CSCC(C)(C)C1)c1ccccc1,benzene_ring
+140231,Please remove a halo from the molecule Cc1cc(N2CCN(C(=O)c3ccc(Cl)s3)CC2)cc(C)[nH+]1.,Cc1cc(N2CCN(C(=O)c3ccc(Cl)s3)CC2)cc(C)[nH+]1,halo
+180666,Modify the molecule CC[C@H]([NH3+])[C@@H](c1ccccc1C)N1CCO[C@H](C#N)C1 by removing a nitrile.,CC[C@H]([NH3+])[C@@H](c1ccccc1C)N1CCO[C@H](C#N)C1,nitrile
+128367,Please remove a hydroxyl from the molecule Cc1cc(F)ccc1CCNC(=O)NC[C@@](C)(O)C(=O)[O-].,Cc1cc(F)ccc1CCNC(=O)NC[C@@](C)(O)C(=O)[O-],hydroxyl
+165071,Remove a nitro from the molecule O=[N+]([O-])c1cccc(-c2csc(N/N=C\c3ccccc3O)n2)c1.,O=[N+]([O-])c1cccc(-c2csc(N/N=C\c3ccccc3O)n2)c1,nitro
+72252,Modify the molecule C[C@H]1OCC[C@H]1C(=O)N1CCN(C(=O)c2ccccc2OC(F)F)CC1 by removing a halo.,C[C@H]1OCC[C@H]1C(=O)N1CCN(C(=O)c2ccccc2OC(F)F)CC1,halo
+21940,Please remove a halo from the molecule CS(=O)(=O)c1ccc(-n2nnnc2COc2cccc(I)c2)cc1.,CS(=O)(=O)c1ccc(-n2nnnc2COc2cccc(I)c2)cc1,halo
+85880,Please remove a amide from the molecule Cc1cccc(NC(=O)[C@H]2CCCN(c3ccnc(-c4ccc(F)cc4)n3)C2)c1.,Cc1cccc(NC(=O)[C@H]2CCCN(c3ccnc(-c4ccc(F)cc4)n3)C2)c1,amide
+219869,Please remove a benzene_ring from the molecule Cc1ccc(C)c(-n2ccnc2SCC(=O)NCC(=O)NC2CC2)c1.,Cc1ccc(C)c(-n2ccnc2SCC(=O)NCC(=O)NC2CC2)c1,benzene_ring
+226784,Remove a amine from the molecule COC(=O)Nc1cc(NCCOc2ccc(F)cc2Cl)ccc1F.,COC(=O)Nc1cc(NCCOc2ccc(F)cc2Cl)ccc1F,amine
+166902,Remove a benzene_ring from the molecule CC[C@H]1CN(C(=O)Nc2ccccc2S(=O)(=O)C(C)C)C[C@H](C)O1.,CC[C@H]1CN(C(=O)Nc2ccccc2S(=O)(=O)C(C)C)C[C@H](C)O1,benzene_ring
+179262,Remove a hydroxyl from the molecule COc1ccc2occ(/C(C)=N/O)c2c1.,COc1ccc2occ(/C(C)=N/O)c2c1,hydroxyl
+186649,Remove a hydroxyl from the molecule C[C@H]1C[NH+]2CCC[C@@H]2CN1c1ccc(/C(N)=N/O)c(Cl)c1.,C[C@H]1C[NH+]2CCC[C@@H]2CN1c1ccc(/C(N)=N/O)c(Cl)c1,hydroxyl
+85716,Remove a amide from the molecule C#Cc1cccc(NC(=S)NNC(=O)CNC(=O)c2ccc(F)cc2F)c1.,C#Cc1cccc(NC(=S)NNC(=O)CNC(=O)c2ccc(F)cc2F)c1,amide
+71925,Modify the molecule Cc1cc(C)cc(NC(=O)N2CCSC(C)(C)C2)c1 by removing a benzene_ring.,Cc1cc(C)cc(NC(=O)N2CCSC(C)(C)C2)c1,benzene_ring
+167582,Modify the molecule COc1cc(F)c([C@@H](C)NC(=O)COC2CCCCC2)cc1OC by removing a halo.,COc1cc(F)c([C@@H](C)NC(=O)COC2CCCCC2)cc1OC,halo
+177720,Please remove a halo from the molecule CN(C(=O)Cn1cccc(C(F)(F)F)c1=O)C1CCOCC1.,CN(C(=O)Cn1cccc(C(F)(F)F)c1=O)C1CCOCC1,halo
+64273,Remove a amide from the molecule Cc1n[nH]c(SCCC(=O)N(C)[C@H](C)Cc2ccsc2)n1.,Cc1n[nH]c(SCCC(=O)N(C)[C@H](C)Cc2ccsc2)n1,amide
+156967,Please remove a amide from the molecule COc1ccccc1[C@H](C#N)NC(=O)c1c(C)cc(C)c([N+](=O)[O-])c1C.,COc1ccccc1[C@H](C#N)NC(=O)c1c(C)cc(C)c([N+](=O)[O-])c1C,amide
+65430,Modify the molecule CCOC(=O)[C@@H](CC)c1nc(CC(F)(F)F)no1 by removing a halo.,CCOC(=O)[C@@H](CC)c1nc(CC(F)(F)F)no1,halo
+245544,Remove a amide from the molecule CCc1cccc2c(CC(=O)N3CC[C@@H]4CC[C@H](C3)[NH+]4C)c[nH]c12.,CCc1cccc2c(CC(=O)N3CC[C@@H]4CC[C@H](C3)[NH+]4C)c[nH]c12,amide
+191386,Modify the molecule C[C@H]1CN(C(=O)Nc2cccc(F)c2)CC[C@@H]1[NH3+] by removing a benzene_ring.,C[C@H]1CN(C(=O)Nc2cccc(F)c2)CC[C@@H]1[NH3+],benzene_ring
+208440,Modify the molecule O=C([C@H]1Cc2ccccc2O1)N1CCN([C@@H]2CCS(=O)(=O)C2)CC1 by removing a amide.,O=C([C@H]1Cc2ccccc2O1)N1CCN([C@@H]2CCS(=O)(=O)C2)CC1,amide
+56969,Remove a benzene_ring from the molecule COC(=O)c1c(NC(=O)C(C)C)sc(C(=O)Nc2cccc(C)c2C)c1C.,COC(=O)c1c(NC(=O)C(C)C)sc(C(=O)Nc2cccc(C)c2C)c1C,benzene_ring
+10423,Please remove a halo from the molecule Cc1c(C[NH2+][C@@H](C)c2ccc(Cl)s2)cnn1C.,Cc1c(C[NH2+][C@@H](C)c2ccc(Cl)s2)cnn1C,halo
+100891,Remove a amide from the molecule CCc1cc([C@H]2CCCN2C(=O)c2ccc(F)cc2)on1.,CCc1cc([C@H]2CCCN2C(=O)c2ccc(F)cc2)on1,amide
+5312,Remove a halo from the molecule COC(=O)c1sc2cccc(F)c2c1CSc1nnnn1C.,COC(=O)c1sc2cccc(F)c2c1CSc1nnnn1C,halo
+161052,Remove a benzene_ring from the molecule CC[C@H](C(=O)OC)N(C(=O)c1ccnc(Cl)c1)c1ccccc1.,CC[C@H](C(=O)OC)N(C(=O)c1ccnc(Cl)c1)c1ccccc1,benzene_ring
+57193,Modify the molecule O=C1CN(S(=O)(=O)c2ccc(-c3ccc(=O)[nH]n3)s2)c2ccccc2N1 by removing a amide.,O=C1CN(S(=O)(=O)c2ccc(-c3ccc(=O)[nH]n3)s2)c2ccccc2N1,amide
+191314,Please remove a amine from the molecule N/C(CSc1ccccc1[N+](=O)[O-])=N\O.,N/C(CSc1ccccc1[N+](=O)[O-])=N\O,amine
+239155,Please remove a amide from the molecule CC(C)(C)C(=O)NNC(=O)NCc1cccc([N+]2=CCCC2)c1.,CC(C)(C)C(=O)NNC(=O)NCc1cccc([N+]2=CCCC2)c1,amide
+59316,Remove a amide from the molecule CCc1cc(=O)[nH]c(-c2cccc(NC(=O)c3ccc4cc[nH]c4c3)c2)n1.,CCc1cc(=O)[nH]c(-c2cccc(NC(=O)c3ccc4cc[nH]c4c3)c2)n1,amide
+93139,Remove a halo from the molecule C#CCOc1ccc(F)cc1NC(=O)N[C@H]1CCCC[C@H]1[S@](=O)CC.,C#CCOc1ccc(F)cc1NC(=O)N[C@H]1CCCC[C@H]1[S@](=O)CC,halo
+241577,Remove a hydroxyl from the molecule Cc1cccc(COc2cccc3c2CC[C@H]3O)n1.,Cc1cccc(COc2cccc3c2CC[C@H]3O)n1,hydroxyl
+212145,Remove a amide from the molecule COC(=O)[C@@H]1CC(=O)N(Cc2ccc3ccccc3c2)C12CC[NH+](Cc1ccco1)CC2.,COC(=O)[C@@H]1CC(=O)N(Cc2ccc3ccccc3c2)C12CC[NH+](Cc1ccco1)CC2,amide
+12418,Remove a amide from the molecule C[C@H](Cc1ccccn1)NC(=O)CN1C(=O)[C@H]2CC[C@@](C)(C1=O)C2(C)C.,C[C@H](Cc1ccccn1)NC(=O)CN1C(=O)[C@H]2CC[C@@](C)(C1=O)C2(C)C,amide
+57272,Modify the molecule COc1cccc(CNC(=O)c2cnc([C@H]3CCCO3)s2)c1O by removing a benzene_ring.,COc1cccc(CNC(=O)c2cnc([C@H]3CCCO3)s2)c1O,benzene_ring
+65014,Modify the molecule Cc1ccc(OC(=O)C=C2CCSCC2)cc1 by removing a benzene_ring.,Cc1ccc(OC(=O)C=C2CCSCC2)cc1,benzene_ring
+19949,Remove a benzene_ring from the molecule CC(=O)Nc1ccc(NC(=O)CN2C(=O)c3cccc4cccc2c34)cc1.,CC(=O)Nc1ccc(NC(=O)CN2C(=O)c3cccc4cccc2c34)cc1,benzene_ring
+198989,Modify the molecule CCOc1ccc(N2C(=O)S/C(=C/c3ccc(-c4ccccc4[N+](=O)[O-])o3)C2=O)cc1 by removing a nitro.,CCOc1ccc(N2C(=O)S/C(=C/c3ccc(-c4ccccc4[N+](=O)[O-])o3)C2=O)cc1,nitro
+7928,Remove a benzene_ring from the molecule [NH3+][C@H]1C[C@H](n2ccc(=O)[nH]c2=O)O[C@@H]1COCc1ccccc1.,[NH3+][C@H]1C[C@H](n2ccc(=O)[nH]c2=O)O[C@@H]1COCc1ccccc1,benzene_ring
+123383,Modify the molecule Cc1nn(C(C)C)c(C)c1CN(C)C(=O)C[C@@H]1C(=O)NCC[NH+]1CC(C)C by removing a amide.,Cc1nn(C(C)C)c(C)c1CN(C)C(=O)C[C@@H]1C(=O)NCC[NH+]1CC(C)C,amide
+133756,Please remove a hydroxyl from the molecule CC[C@](C)([C@@H](O)c1cnccn1)[NH+]1CCCCC1.,CC[C@](C)([C@@H](O)c1cnccn1)[NH+]1CCCCC1,hydroxyl
+100643,Please remove a amide from the molecule CC[C@@H](C)C(=O)NC[C@@H](C)Oc1ccc(Cl)cc1.,CC[C@@H](C)C(=O)NC[C@@H](C)Oc1ccc(Cl)cc1,amide
+66696,Modify the molecule C[C@H](Nc1nccc(Oc2ccc(F)cc2)n1)c1cccc(S(N)(=O)=O)c1 by removing a benzene_ring.,C[C@H](Nc1nccc(Oc2ccc(F)cc2)n1)c1cccc(S(N)(=O)=O)c1,benzene_ring
+184231,Remove a benzene_ring from the molecule COc1cccc(CNc2ncnc3sccc23)c1.,COc1cccc(CNc2ncnc3sccc23)c1,benzene_ring
+161712,Modify the molecule CC(C)(C)C1CCC(=CC(=O)NC[C@@H]2CCCN(c3ncccn3)C2)CC1 by removing a amide.,CC(C)(C)C1CCC(=CC(=O)NC[C@@H]2CCCN(c3ncccn3)C2)CC1,amide
+145214,Remove a amide from the molecule Cn1cccc(NC(=O)c2[nH]c3ccc(Cl)cc3c2Cl)c1=O.,Cn1cccc(NC(=O)c2[nH]c3ccc(Cl)cc3c2Cl)c1=O,amide
+180853,Modify the molecule C[C@@H]1CCCN1C(=O)c1cc(C(F)(F)F)ccc1NN by removing a halo.,C[C@@H]1CCCN1C(=O)c1cc(C(F)(F)F)ccc1NN,halo
+212008,Modify the molecule COc1ccc(CN2CCO[C@@H](CO)C2)cc1[N+](=O)[O-] by removing a benzene_ring.,COc1ccc(CN2CCO[C@@H](CO)C2)cc1[N+](=O)[O-],benzene_ring
+98857,Remove a halo from the molecule O=C(c1cccc(Br)c1)N1CCN(C(=O)N2CCCCC2)CC1.,O=C(c1cccc(Br)c1)N1CCN(C(=O)N2CCCCC2)CC1,halo
+39204,Remove a hydroxyl from the molecule Oc1ccccc1/C=N/N1C(=S)[NH+]=N[C@@H]1c1ccc(Cl)cc1Cl.,Oc1ccccc1/C=N/N1C(=S)[NH+]=N[C@@H]1c1ccc(Cl)cc1Cl,hydroxyl
+183977,Modify the molecule Cc1cc([N+](=O)[O-])ccc1NC(=O)C(=O)NCC(C)(C)[C@H](O)c1ccccc1 by removing a hydroxyl.,Cc1cc([N+](=O)[O-])ccc1NC(=O)C(=O)NCC(C)(C)[C@H](O)c1ccccc1,hydroxyl
+220644,Please remove a amide from the molecule COCCn1nnnc1C[NH+]1[C@H]2CCC[C@@H]1CC(NC(C)=O)C2.,COCCn1nnnc1C[NH+]1[C@H]2CCC[C@@H]1CC(NC(C)=O)C2,amide
+191843,Modify the molecule COc1ccc([C@@H]2NC(=O)C3=NN=C(c4ccc(C)cc4)[C@H]32)cc1 by removing a benzene_ring.,COc1ccc([C@@H]2NC(=O)C3=NN=C(c4ccc(C)cc4)[C@H]32)cc1,benzene_ring
+77709,Remove a hydroxyl from the molecule CCC1CCC(C[NH3+])([C@@H](O)c2ccccc2F)CC1.,CCC1CCC(C[NH3+])([C@@H](O)c2ccccc2F)CC1,hydroxyl
+181903,Modify the molecule Cc1nc2sc([C@@H](c3ccccc3Cl)N(C)Cc3ccccc3)c([O-])n2n1 by removing a benzene_ring.,Cc1nc2sc([C@@H](c3ccccc3Cl)N(C)Cc3ccccc3)c([O-])n2n1,benzene_ring
+69428,Modify the molecule COc1ccc(N2C(=O)C[C@H]([C@@H]3C(=O)N(c4ccccc4)N=C3C)C2=O)cc1 by removing a benzene_ring.,COc1ccc(N2C(=O)C[C@H]([C@@H]3C(=O)N(c4ccccc4)N=C3C)C2=O)cc1,benzene_ring
+187779,Please remove a halo from the molecule FC(F)Oc1ccc(N2CCCC3(C2)OCCO3)nc1.,FC(F)Oc1ccc(N2CCCC3(C2)OCCO3)nc1,halo
+203945,Remove a amide from the molecule CCCC(=O)N1CCC[C@@H](C(=O)NC(C)(C)c2nc(C)c(C)s2)C1.,CCCC(=O)N1CCC[C@@H](C(=O)NC(C)(C)c2nc(C)c(C)s2)C1,amide
+8456,Modify the molecule O=C(N[C@H]1CC=CCC1)N[C@@H]1CCCN(c2ccccc2)C1=O by removing a amide.,O=C(N[C@H]1CC=CCC1)N[C@@H]1CCCN(c2ccccc2)C1=O,amide
+8853,Modify the molecule COc1ccccc1-c1nnc(S[C@@H](C)C(=O)Nc2ccccc2C)n1C by removing a amide.,COc1ccccc1-c1nnc(S[C@@H](C)C(=O)Nc2ccccc2C)n1C,amide
+164056,Modify the molecule Cc1[nH]c(SCC(=O)NCC(=O)N(C)C)nc1Cc1ccccc1 by removing a amide.,Cc1[nH]c(SCC(=O)NCC(=O)N(C)C)nc1Cc1ccccc1,amide
+136596,Please remove a amine from the molecule Cc1cc(Cl)ccc1Nc1ncnc(NCc2cccnc2)c1[N+](=O)[O-].,Cc1cc(Cl)ccc1Nc1ncnc(NCc2cccnc2)c1[N+](=O)[O-],amine
+88420,Please remove a halo from the molecule COc1ccc(-c2noc(CCC(=O)N(C)Cc3ccccc3F)n2)cc1.,COc1ccc(-c2noc(CCC(=O)N(C)Cc3ccccc3F)n2)cc1,halo
+110252,Modify the molecule CN(C)c1ccccc1NC(=O)NCCCc1nnc2n1CCCCC2 by removing a benzene_ring.,CN(C)c1ccccc1NC(=O)NCCCc1nnc2n1CCCCC2,benzene_ring
+129658,Modify the molecule COC(=O)[C@@]1(F)CCN(S(=O)(=O)c2c(F)cccc2F)C1 by removing a benzene_ring.,COC(=O)[C@@]1(F)CCN(S(=O)(=O)c2c(F)cccc2F)C1,benzene_ring
+111997,Remove a benzene_ring from the molecule O=C([O-])CCC[NH+]1CCC[C@]2(CCC(=O)N(CCc3ccccc3)C2)C1.,O=C([O-])CCC[NH+]1CCC[C@]2(CCC(=O)N(CCc3ccccc3)C2)C1,benzene_ring
+10366,Please remove a benzene_ring from the molecule Cc1cncc(C(=O)O[C@H](Cn2cncn2)c2ccccc2)c1.,Cc1cncc(C(=O)O[C@H](Cn2cncn2)c2ccccc2)c1,benzene_ring
+158272,Remove a amide from the molecule Cc1nc(N2C(=O)C([O-])=C(C(=O)c3ccccc3)[C@@H]2c2cccc(Cl)c2)sc1C.,Cc1nc(N2C(=O)C([O-])=C(C(=O)c3ccccc3)[C@@H]2c2cccc(Cl)c2)sc1C,amide
+6777,Modify the molecule C[C@@H](C(=O)N1CCCCCC1)S(=O)(=O)c1ccccc1F by removing a halo.,C[C@@H](C(=O)N1CCCCCC1)S(=O)(=O)c1ccccc1F,halo
+202563,Remove a benzene_ring from the molecule COc1ccccc1[C@@H]1C[C@H](c2ccccc2)Nc2ncnn21.,COc1ccccc1[C@@H]1C[C@H](c2ccccc2)Nc2ncnn21,benzene_ring
+140963,Modify the molecule C[C@@H](OC(=O)c1cc(-c2ccc(Br)cc2)n[nH]1)c1nnc(-c2ccc([N+](=O)[O-])cc2)o1 by removing a benzene_ring.,C[C@@H](OC(=O)c1cc(-c2ccc(Br)cc2)n[nH]1)c1nnc(-c2ccc([N+](=O)[O-])cc2)o1,benzene_ring
+40106,Remove a benzene_ring from the molecule COc1ccccc1[C@H](CNC(=O)N(C)Cc1ncnn1C)[NH+]1CCCC1.,COc1ccccc1[C@H](CNC(=O)N(C)Cc1ncnn1C)[NH+]1CCCC1,benzene_ring
+100632,Remove a benzene_ring from the molecule Cc1cc(C)n(-c2ccc(C(=O)NCc3cscn3)cc2)n1.,Cc1cc(C)n(-c2ccc(C(=O)NCc3cscn3)cc2)n1,benzene_ring
+159225,Remove a amide from the molecule CCC(=O)N[C@H](C)c1nc2ccccc2n1Cc1c(C)cc(C)cc1C.,CCC(=O)N[C@H](C)c1nc2ccccc2n1Cc1c(C)cc(C)cc1C,amide
+140807,Modify the molecule CC[C@H]([NH2+][C@H](C)CC1CCOCC1)c1cc(F)ccc1F by removing a benzene_ring.,CC[C@H]([NH2+][C@H](C)CC1CCOCC1)c1cc(F)ccc1F,benzene_ring
+115232,Remove a benzene_ring from the molecule O=C(Nc1ccccc1F)[C@@H]1CSCN1C(=O)C=C1CCSCC1.,O=C(Nc1ccccc1F)[C@@H]1CSCN1C(=O)C=C1CCSCC1,benzene_ring
+211028,Please remove a amide from the molecule Cc1ccc(C(O)(C(=O)Nc2ccccn2)c2ccc(C)cc2)cc1.,Cc1ccc(C(O)(C(=O)Nc2ccccn2)c2ccc(C)cc2)cc1,amide
+15127,Please remove a amide from the molecule C[C@H]1CC(C(=O)N[C@@H]2CC(=O)N(C)[C@@H]2c2ccc(Cl)cc2)C[C@@H](C)O1.,C[C@H]1CC(C(=O)N[C@@H]2CC(=O)N(C)[C@@H]2c2ccc(Cl)cc2)C[C@@H](C)O1,amide
+41658,Modify the molecule CC(C)(C)C(=O)N1CCN(C(=O)Nc2cccc(OC3CCCC3)c2)CC1 by removing a amide.,CC(C)(C)C(=O)N1CCN(C(=O)Nc2cccc(OC3CCCC3)c2)CC1,amide
+103871,Please remove a amide from the molecule CC(C)COC(=O)c1ccccc1SCC(=O)N1CCCC1.,CC(C)COC(=O)c1ccccc1SCC(=O)N1CCCC1,amide
+119586,Please remove a halo from the molecule CCN(Cc1ccc(Cl)s1)C(=O)NC[C@H]1CCOC1.,CCN(Cc1ccc(Cl)s1)C(=O)NC[C@H]1CCOC1,halo
+57860,Please remove a benzene_ring from the molecule COc1ccccc1NC1CCN(C(=O)C(=O)Nc2ccc(C)cc2)CC1.,COc1ccccc1NC1CCN(C(=O)C(=O)Nc2ccc(C)cc2)CC1,benzene_ring
+67539,Remove a amine from the molecule C[C@@H]1Cc2ccccc2N1CCNC(=O)c1ccc(NS(=O)(=O)c2ccccc2)cc1.,C[C@@H]1Cc2ccccc2N1CCNC(=O)c1ccc(NS(=O)(=O)c2ccccc2)cc1,amine
+226294,Remove a amine from the molecule c1ccc2c3c([nH]c2c1)CC[C@H](N[C@@H]1CC[NH+](C2CCCC2)C1)C3.,c1ccc2c3c([nH]c2c1)CC[C@H](N[C@@H]1CC[NH+](C2CCCC2)C1)C3,amine
+9779,Please remove a amide from the molecule CO[C@H](C)C(=O)N1CCN(C(=O)Cc2c[nH]c3ccccc23)CC1.,CO[C@H](C)C(=O)N1CCN(C(=O)Cc2c[nH]c3ccccc23)CC1,amide
+121657,Please remove a amide from the molecule O=C(CCCn1ccnn1)N1CCN(Cc2noc(-c3cccs3)n2)CC1.,O=C(CCCn1ccnn1)N1CCN(Cc2noc(-c3cccs3)n2)CC1,amide
+13636,Please remove a benzene_ring from the molecule CNC(=O)c1cccc(NCc2cn(-c3ccccc3)nc2C(C)C)c1C.,CNC(=O)c1cccc(NCc2cn(-c3ccccc3)nc2C(C)C)c1C,benzene_ring
+146459,Remove a amide from the molecule CN1CCC/C1=N\S(=O)(=O)c1cccc(NC(=O)CCn2cnc3ccccc32)c1.,CN1CCC/C1=N\S(=O)(=O)c1cccc(NC(=O)CCn2cnc3ccccc32)c1,amide
+93382,Remove a amide from the molecule O=C(Nc1cc(-c2ccco2)ccc1F)c1cn2cccnc2n1.,O=C(Nc1cc(-c2ccco2)ccc1F)c1cn2cccnc2n1,amide
+213076,Modify the molecule CN(Cc1cc2ccccc2o1)C(=O)c1ccc(-c2cscn2)cc1 by removing a benzene_ring.,CN(Cc1cc2ccccc2o1)C(=O)c1ccc(-c2cscn2)cc1,benzene_ring
+38249,Modify the molecule Cc1nnsc1C(=O)N/N=C/c1ccc([N+](=O)[O-])s1 by removing a nitro.,Cc1nnsc1C(=O)N/N=C/c1ccc([N+](=O)[O-])s1,nitro
+194287,Remove a amide from the molecule Cc1cc(C)cc(N2CCN(C(=O)[C@@H]3CN(C)C(=O)N3)CC2=O)c1.,Cc1cc(C)cc(N2CCN(C(=O)[C@@H]3CN(C)C(=O)N3)CC2=O)c1,amide
+101774,Please remove a benzene_ring from the molecule O=C(Oc1ccc(-n2cnnn2)cc1)c1ccc(F)cc1.,O=C(Oc1ccc(-n2cnnn2)cc1)c1ccc(F)cc1,benzene_ring
+200299,Please remove a amide from the molecule CN(C)c1cccc(C(=O)Nn2cnc3ccccc3c2=O)c1.,CN(C)c1cccc(C(=O)Nn2cnc3ccccc3c2=O)c1,amide
+23258,Remove a hydroxyl from the molecule COc1cccc(OC[C@@H](O)CN2CCN(c3cc(Cl)ccc3C)CC2)c1.,COc1cccc(OC[C@@H](O)CN2CCN(c3cc(Cl)ccc3C)CC2)c1,hydroxyl
+11793,Remove a benzene_ring from the molecule CN(C)c1ccc(-c2nnn(CC(=O)N3CCCCCC3)n2)cc1.,CN(C)c1ccc(-c2nnn(CC(=O)N3CCCCCC3)n2)cc1,benzene_ring
+108754,Please remove a benzene_ring from the molecule Cc1ccc(C(=O)CCC(=O)NCc2ccc(N3CCOCC3)[nH+]c2)cc1.,Cc1ccc(C(=O)CCC(=O)NCc2ccc(N3CCOCC3)[nH+]c2)cc1,benzene_ring
+241223,Remove a benzene_ring from the molecule C[C@H](CN(C)C(=O)N[C@@H]1CC[NH+](C2CCCC2)C1)c1ccccc1.,C[C@H](CN(C)C(=O)N[C@@H]1CC[NH+](C2CCCC2)C1)c1ccccc1,benzene_ring
+242029,Please remove a amide from the molecule Cc1ccc(Cc2nnc(NC(=O)[C@H]3CCCCN3S(=O)(=O)c3cccs3)o2)cc1C.,Cc1ccc(Cc2nnc(NC(=O)[C@H]3CCCCN3S(=O)(=O)c3cccs3)o2)cc1C,amide
+211619,Modify the molecule C[C@H]1CCCC[C@H]1N1C(=O)C(=O)N(Cc2cccc(S(=O)(=O)N3CCOCC3)c2)C1=O by removing a amide.,C[C@H]1CCCC[C@H]1N1C(=O)C(=O)N(Cc2cccc(S(=O)(=O)N3CCOCC3)c2)C1=O,amide
+93549,Remove a benzene_ring from the molecule COc1ccc(/C=C/C(=O)N[C@H](C)C(=O)N[C@H]2[C@@H]3CCO[C@@H]3C2(C)C)cc1.,COc1ccc(/C=C/C(=O)N[C@H](C)C(=O)N[C@H]2[C@@H]3CCO[C@@H]3C2(C)C)cc1,benzene_ring
+108561,Remove a amine from the molecule COc1ccccc1[C@@H](NS(=O)(=O)C[C@@H]1CCOC1)c1ccccn1.,COc1ccccc1[C@@H](NS(=O)(=O)C[C@@H]1CCOC1)c1ccccn1,amine
+107710,Modify the molecule CNC(=O)c1ccccc1NC(=O)[C@@H]1C[C@@H]2C=C[C@H]1C2 by removing a amide.,CNC(=O)c1ccccc1NC(=O)[C@@H]1C[C@@H]2C=C[C@H]1C2,amide
+29615,Please remove a amide from the molecule C/C=C/C=C/C(=O)Nc1ccnn1Cc1ccc(Br)cc1.,C/C=C/C=C/C(=O)Nc1ccnn1Cc1ccc(Br)cc1,amide
+65808,Please remove a amine from the molecule Cc1ccc(OCC(=O)NC(=S)Nc2cccc(C(=O)[O-])c2C)cc1.,Cc1ccc(OCC(=O)NC(=S)Nc2cccc(C(=O)[O-])c2C)cc1,amine
+217862,Remove a benzene_ring from the molecule C[NH2+]CCSCc1ccccc1.,C[NH2+]CCSCc1ccccc1,benzene_ring
+184235,Remove a halo from the molecule CC(C)N(C)C(=O)N[C@@H](C)c1c(Cl)ccc(F)c1Cl.,CC(C)N(C)C(=O)N[C@@H](C)c1c(Cl)ccc(F)c1Cl,halo
+132484,Modify the molecule O=C(c1ccc2c(c1)COCO2)N1CCCC[C@H]1CCO by removing a amide.,O=C(c1ccc2c(c1)COCO2)N1CCCC[C@H]1CCO,amide
+113473,Modify the molecule CC(C)c1nc(-c2ccc(N3CCN(C(=O)Cc4noc5ccccc45)CC3)[nH+]c2)no1 by removing a amide.,CC(C)c1nc(-c2ccc(N3CCN(C(=O)Cc4noc5ccccc45)CC3)[nH+]c2)no1,amide
+189828,Remove a benzene_ring from the molecule C[C@@H](Cc1cccs1)N(C)S(=O)(=O)c1ccc(O)cc1.,C[C@@H](Cc1cccs1)N(C)S(=O)(=O)c1ccc(O)cc1,benzene_ring
+229882,Remove a benzene_ring from the molecule CCOc1ccc([C@@H]2SCC(=O)Nc3c2c(C)nn3-c2nc3ccccc3s2)cc1.,CCOc1ccc([C@@H]2SCC(=O)Nc3c2c(C)nn3-c2nc3ccccc3s2)cc1,benzene_ring
+224675,Remove a halo from the molecule O=C(Cc1ccccc1C(F)(F)F)N[C@@H](CO)c1ccco1.,O=C(Cc1ccccc1C(F)(F)F)N[C@@H](CO)c1ccco1,halo
+195066,Please remove a amide from the molecule Cc1cccc(-n2ncc3c(=O)n4c(nc32)SC[C@@H]4CC(=O)NCCCn2ccnc2)c1.,Cc1cccc(-n2ncc3c(=O)n4c(nc32)SC[C@@H]4CC(=O)NCCCn2ccnc2)c1,amide
+64114,Modify the molecule C[C@H](O)[C@H]1CCC[NH+](CC(=O)Nc2ccccc2Oc2ccccc2)C1 by removing a amide.,C[C@H](O)[C@H]1CCC[NH+](CC(=O)Nc2ccccc2Oc2ccccc2)C1,amide
+33883,Modify the molecule Cc1occc1-c1nnc(SCC(=O)Nc2ccccc2Cl)n1C[C@H]1CCCO1 by removing a benzene_ring.,Cc1occc1-c1nnc(SCC(=O)Nc2ccccc2Cl)n1C[C@H]1CCCO1,benzene_ring
+176031,Modify the molecule CCN1CC(=O)N(CC(C)(C)C(=O)NN)CC1=O by removing a amide.,CCN1CC(=O)N(CC(C)(C)C(=O)NN)CC1=O,amide
+44981,Modify the molecule Cn1c(=O)/c(=C\c2ccsc2)s/c1=C(\C#N)C(=O)c1ccccc1F by removing a halo.,Cn1c(=O)/c(=C\c2ccsc2)s/c1=C(\C#N)C(=O)c1ccccc1F,halo
+76354,Modify the molecule COC(=O)C[C@@H](C[NH3+])c1ccccc1OC by removing a benzene_ring.,COC(=O)C[C@@H](C[NH3+])c1ccccc1OC,benzene_ring
+6684,Remove a benzene_ring from the molecule O=C(NCc1ccc(F)c(Cl)c1)NC[C@@H]1CCCN(c2ncccn2)C1.,O=C(NCc1ccc(F)c(Cl)c1)NC[C@@H]1CCCN(c2ncccn2)C1,benzene_ring
+96882,Modify the molecule c1ccc(CN2CC[C@@H](c3nc(-c4ccncc4)no3)C2)cc1 by removing a benzene_ring.,c1ccc(CN2CC[C@@H](c3nc(-c4ccncc4)no3)C2)cc1,benzene_ring
+94261,Please remove a hydroxyl from the molecule CC1CCC(N2C[C@@H](C(=O)N[C@H](CO)c3ccco3)CC2=O)CC1.,CC1CCC(N2C[C@@H](C(=O)N[C@H](CO)c3ccco3)CC2=O)CC1,hydroxyl
+234733,Remove a benzene_ring from the molecule C[NH+](Cc1nccn1Cc1ccccc1)[C@H]1CCCC[C@@H]1O.,C[NH+](Cc1nccn1Cc1ccccc1)[C@H]1CCCC[C@@H]1O,benzene_ring
+58292,Please remove a amide from the molecule CC1CCC(NC(=O)C(=O)Nc2ccccc2C[NH+]2CCCC2)CC1.,CC1CCC(NC(=O)C(=O)Nc2ccccc2C[NH+]2CCCC2)CC1,amide
+197264,Please remove a benzene_ring from the molecule Cc1c(CCC(=O)N(C)[C@H](C)Cc2ccc(O)cc2)cnn1C.,Cc1c(CCC(=O)N(C)[C@H](C)Cc2ccc(O)cc2)cnn1C,benzene_ring
+132486,Modify the molecule Cc1cc(-n2c(C)cc(/C=C/C(=O)Nc3cccc(C(N)=O)c3)c2C)no1 by removing a amide.,Cc1cc(-n2c(C)cc(/C=C/C(=O)Nc3cccc(C(N)=O)c3)c2C)no1,amide
+74660,Modify the molecule C[C@H]1CCC[C@H]([C@H](O)C2(C#N)CCC2)C1 by removing a hydroxyl.,C[C@H]1CCC[C@H]([C@H](O)C2(C#N)CCC2)C1,hydroxyl
+102177,Remove a amide from the molecule Cc1cccc2nc(C(=O)N3CCC[C@@H](C(=O)[O-])C3)cn12.,Cc1cccc2nc(C(=O)N3CCC[C@@H](C(=O)[O-])C3)cn12,amide
+246363,Remove a benzene_ring from the molecule Cc1ccccc1CC[NH2+]C[C@H](C#N)c1ccccc1.,Cc1ccccc1CC[NH2+]C[C@H](C#N)c1ccccc1,benzene_ring
+62029,Please remove a amide from the molecule COc1ccc([C@@H]2SCC(=O)N2c2ccccc2)cc1OC.,COc1ccc([C@@H]2SCC(=O)N2c2ccccc2)cc1OC,amide
+10329,Please remove a amide from the molecule C#CC[NH2+]CC(=O)Nc1ccc(F)cc1C(=O)[O-].,C#CC[NH2+]CC(=O)Nc1ccc(F)cc1C(=O)[O-],amide
+175396,Modify the molecule CCn1cc(NC(=O)[C@H]2CSCN2C(=O)CC(C)(C)C)ccc1=O by removing a amide.,CCn1cc(NC(=O)[C@H]2CSCN2C(=O)CC(C)(C)C)ccc1=O,amide
+189172,Modify the molecule CC[C@H](C)[NH2+]Cc1ccc(-c2ccccc2)o1 by removing a benzene_ring.,CC[C@H](C)[NH2+]Cc1ccc(-c2ccccc2)o1,benzene_ring
+148253,Please remove a benzene_ring from the molecule Cc1cc(C)cc(N2C(=O)N(Cc3cccc(Cl)c3)[C@H]3CS(=O)(=O)C[C@H]32)c1.,Cc1cc(C)cc(N2C(=O)N(Cc3cccc(Cl)c3)[C@H]3CS(=O)(=O)C[C@H]32)c1,benzene_ring
+58240,Remove a amide from the molecule CCC(C)(C)NC(=O)[C@H](C)[S@@](=O)Cc1ccc(C(=O)NC)cc1.,CCC(C)(C)NC(=O)[C@H](C)[S@@](=O)Cc1ccc(C(=O)NC)cc1,amide
+203939,Remove a amine from the molecule CC(C)C[NH+]1CCn2nc(CNC(=O)Cc3csc4[n+]3CCN4)cc2C1.,CC(C)C[NH+]1CCn2nc(CNC(=O)Cc3csc4[n+]3CCN4)cc2C1,amine
+171694,Modify the molecule [NH2+]=c1oc2ccc(Cl)cc2cc1C(=O)Nc1ccc(Cl)cc1Cl by removing a amide.,[NH2+]=c1oc2ccc(Cl)cc2cc1C(=O)Nc1ccc(Cl)cc1Cl,amide
+206565,Remove a benzene_ring from the molecule O=C(Cc1nnc(NC(=O)Nc2ccccc2)s1)N/N=C/c1cccs1.,O=C(Cc1nnc(NC(=O)Nc2ccccc2)s1)N/N=C/c1cccs1,benzene_ring
+130365,Please remove a benzene_ring from the molecule O=C(NCCC(=O)N1CCN(C[C@H]2CCCO2)CC1)c1ccc(Br)cc1.,O=C(NCCC(=O)N1CCN(C[C@H]2CCCO2)CC1)c1ccc(Br)cc1,benzene_ring
+192894,Modify the molecule O=C(NC[C@H](c1ccc2c(c1)OCO2)N1CCOCC1)C(=O)Nc1ccccc1F by removing a benzene_ring.,O=C(NC[C@H](c1ccc2c(c1)OCO2)N1CCOCC1)C(=O)Nc1ccccc1F,benzene_ring
+139730,Please remove a benzene_ring from the molecule CC(C)[C@@H](CO)NC(=O)NCc1ccccc1OC(C)(C)C.,CC(C)[C@@H](CO)NC(=O)NCc1ccccc1OC(C)(C)C,benzene_ring
+145611,Remove a benzene_ring from the molecule CCn1nc(C)c(CN2CC[NH+](Cc3ccccc3)C[C@H]2C)c1C.,CCn1nc(C)c(CN2CC[NH+](Cc3ccccc3)C[C@H]2C)c1C,benzene_ring
+205308,Please remove a amide from the molecule COc1ccc(OC)c([C@H]2CCC[NH+]2[C@H](C)C(=O)Nc2ccc(C(C)=O)cc2)c1.,COc1ccc(OC)c([C@H]2CCC[NH+]2[C@H](C)C(=O)Nc2ccc(C(C)=O)cc2)c1,amide
+50236,Remove a benzene_ring from the molecule COc1ccc(-n2nc(C(=O)N3CCC([C@@H](C)O)CC3)cc2C)cc1.,COc1ccc(-n2nc(C(=O)N3CCC([C@@H](C)O)CC3)cc2C)cc1,benzene_ring
+198714,Please remove a amide from the molecule CCOC(=O)C1CCN(C(=O)C2(c3cc(-c4ccc(Cl)cc4)on3)CC2)CC1.,CCOC(=O)C1CCN(C(=O)C2(c3cc(-c4ccc(Cl)cc4)on3)CC2)CC1,amide
+202409,Remove a amide from the molecule Cc1nn(C(C)C)c(C)c1NC(=O)[C@H]1CCCN(c2ncccn2)C1.,Cc1nn(C(C)C)c(C)c1NC(=O)[C@H]1CCCN(c2ncccn2)C1,amide
+94743,Modify the molecule CCCC(=O)c1ccn(C[C@H](C)C(N)=O)c1 by removing a amide.,CCCC(=O)c1ccn(C[C@H](C)C(N)=O)c1,amide
+138671,Please remove a benzene_ring from the molecule CS(=O)(=O)c1ccc2nc([N-]S(=O)(=O)c3ccc(I)cc3)sc2c1.,CS(=O)(=O)c1ccc2nc([N-]S(=O)(=O)c3ccc(I)cc3)sc2c1,benzene_ring
+82248,Please remove a hydroxyl from the molecule CC[C@@H](O)C[NH+](Cc1ccco1)C[C@@H]1CCCO1.,CC[C@@H](O)C[NH+](Cc1ccco1)C[C@@H]1CCCO1,hydroxyl
+121866,Please remove a benzene_ring from the molecule COc1ccc(-c2ccc(C(=O)[O-])c(N)c2)cc1.,COc1ccc(-c2ccc(C(=O)[O-])c(N)c2)cc1,benzene_ring
+17260,Modify the molecule O=C(CCSc1nc2ccccc2s1)Nc1ccc2oc(=O)[nH]c2c1 by removing a amide.,O=C(CCSc1nc2ccccc2s1)Nc1ccc2oc(=O)[nH]c2c1,amide
+227098,Please remove a amide from the molecule COc1ccc(C(=O)NCc2ccccc2OCC(C)C)nn1.,COc1ccc(C(=O)NCc2ccccc2OCC(C)C)nn1,amide
+175173,Please remove a amide from the molecule Cc1nc2ccccc2n1CCNC(=O)c1cc(Cl)cc(Cl)c1.,Cc1nc2ccccc2n1CCNC(=O)c1cc(Cl)cc(Cl)c1,amide
+137241,Please remove a benzene_ring from the molecule O=C([O-])[C@H]1CC=CC[C@H]1C(=O)Nc1ccc(S(=O)(=O)N2CCc3ccccc32)cc1.,O=C([O-])[C@H]1CC=CC[C@H]1C(=O)Nc1ccc(S(=O)(=O)N2CCc3ccccc32)cc1,benzene_ring
+224488,Remove a benzene_ring from the molecule CCCCN(C(=O)Cn1nc2ccccn2c1=O)[C@@H](C)c1ccccc1.,CCCCN(C(=O)Cn1nc2ccccn2c1=O)[C@@H](C)c1ccccc1,benzene_ring
+191067,Modify the molecule O=C(CNc1ccc(C(F)(F)F)cc1Cl)NC(=O)NC1CC1 by removing a amide.,O=C(CNc1ccc(C(F)(F)F)cc1Cl)NC(=O)NC1CC1,amide
+9096,Remove a amide from the molecule CCOC(=O)[C@]12C(=C(c3ccccc3)O[C@@H]3C=CCC[C@H]31)C(=O)C(=O)N2c1ccccc1.,CCOC(=O)[C@]12C(=C(c3ccccc3)O[C@@H]3C=CCC[C@H]31)C(=O)C(=O)N2c1ccccc1,amide
+54463,Remove a benzene_ring from the molecule Cc1cccc(C)c1NC(=O)C[NH2+][C@H](C)Cn1cnc(C)c1C.,Cc1cccc(C)c1NC(=O)C[NH2+][C@H](C)Cn1cnc(C)c1C,benzene_ring
+77400,Modify the molecule O=C(c1ccc([N+](=O)[O-])o1)N(Cc1ccccn1)c1ccc(F)cc1 by removing a amide.,O=C(c1ccc([N+](=O)[O-])o1)N(Cc1ccccn1)c1ccc(F)cc1,amide
+133004,Remove a halo from the molecule COC(=O)C1=C(C)Nc2[nH]c(=S)[nH]c(=O)c2[C@H]1c1ccccc1Cl.,COC(=O)C1=C(C)Nc2[nH]c(=S)[nH]c(=O)c2[C@H]1c1ccccc1Cl,halo
+94170,Please remove a hydroxyl from the molecule COc1cc(C[NH+]2CCC([C@H](O)c3nccn3C)CC2)cc(OC)c1.,COc1cc(C[NH+]2CCC([C@H](O)c3nccn3C)CC2)cc(OC)c1,hydroxyl
+95953,Please remove a benzene_ring from the molecule Cc1nc2c(-c3cccs3)nc(=O)n(Cc3ccc(Cl)cc3Cl)c2s1.,Cc1nc2c(-c3cccs3)nc(=O)n(Cc3ccc(Cl)cc3Cl)c2s1,benzene_ring
+167181,Please remove a benzene_ring from the molecule CC(C)(C)OC(=O)N1CCCC[C@@H]1C(=O)N(Cc1ccccc1F)C1CC1.,CC(C)(C)OC(=O)N1CCCC[C@@H]1C(=O)N(Cc1ccccc1F)C1CC1,benzene_ring
+108174,Remove a amide from the molecule CC(=O)Nc1cccc(-n2c(C)nn(C[C@H](O)c3ccccc3)c2=S)c1.,CC(=O)Nc1cccc(-n2c(C)nn(C[C@H](O)c3ccccc3)c2=S)c1,amide
+87586,Modify the molecule CCOc1ccc(C(=O)c2ccc(F)cc2)cc1OCC by removing a halo.,CCOc1ccc(C(=O)c2ccc(F)cc2)cc1OCC,halo
+54995,Modify the molecule Cc1c(C)c(C)c([C@@H]([NH3+])CO)c(C)c1C by removing a hydroxyl.,Cc1c(C)c(C)c([C@@H]([NH3+])CO)c(C)c1C,hydroxyl
+174962,Please remove a amide from the molecule O=C(c1cccc([N+](=O)[O-])c1)N1CCN=C1SCc1cccc(C(F)(F)F)c1.,O=C(c1cccc([N+](=O)[O-])c1)N1CCN=C1SCc1cccc(C(F)(F)F)c1,amide
+131876,Remove a amide from the molecule COc1cccc(C(=O)N2CCN(C(=O)CCc3cccnc3)CC2)c1.,COc1cccc(C(=O)N2CCN(C(=O)CCc3cccnc3)CC2)c1,amide
+239527,Please remove a benzene_ring from the molecule O=C(N1CCC(NS(=O)(=O)c2ccc(Cl)cc2)CC1)C1(c2ccccc2)CC1.,O=C(N1CCC(NS(=O)(=O)c2ccc(Cl)cc2)CC1)C1(c2ccccc2)CC1,benzene_ring
+156628,Remove a nitro from the molecule Cc1ccc(NCc2ccc(C3CC3)cc2)cc1[N+](=O)[O-].,Cc1ccc(NCc2ccc(C3CC3)cc2)cc1[N+](=O)[O-],nitro
+83277,Remove a nitrile from the molecule Cc1cccc(C)c1OCC(=O)[C@H](C#N)c1nnc(-c2ccccc2)n1C.,Cc1cccc(C)c1OCC(=O)[C@H](C#N)c1nnc(-c2ccccc2)n1C,nitrile
+227288,Remove a benzene_ring from the molecule CCOc1ccc(S(=O)(=O)Nc2ccc3c(c2)N(CC(C)C)C(=O)C(C)(C)CO3)cc1.,CCOc1ccc(S(=O)(=O)Nc2ccc3c(c2)N(CC(C)C)C(=O)C(C)(C)CO3)cc1,benzene_ring
+34754,Please remove a halo from the molecule CCn1cc(Br)c(CN(C)S(=O)(=O)c2cnn(CC)c2C)n1.,CCn1cc(Br)c(CN(C)S(=O)(=O)c2cnn(CC)c2C)n1,halo
+48985,Remove a halo from the molecule C[C@H](Cc1ccccc1F)C(=O)N[C@H]1CCS(=O)(=O)C1.,C[C@H](Cc1ccccc1F)C(=O)N[C@H]1CCS(=O)(=O)C1,halo
+39577,Remove a benzene_ring from the molecule CC[C@H](CSC)NC(=O)NCCc1ccccc1C.,CC[C@H](CSC)NC(=O)NCCc1ccccc1C,benzene_ring
+36877,Modify the molecule Cc1cc(C)n(-c2ccc(C(=O)N(C)[C@@H]3CCC[C@H](C)C3)cn2)n1 by removing a amide.,Cc1cc(C)n(-c2ccc(C(=O)N(C)[C@@H]3CCC[C@H](C)C3)cn2)n1,amide
+165531,Please remove a benzene_ring from the molecule Cc1cc(C)c(NC(=O)c2cccc(NC(=O)c3ccco3)c2)c(C)c1.,Cc1cc(C)c(NC(=O)c2cccc(NC(=O)c3ccco3)c2)c(C)c1,benzene_ring
+81436,Modify the molecule CCc1ccc(NC(=O)Cc2csc(COc3cccc(C)c3)n2)cc1 by removing a amide.,CCc1ccc(NC(=O)Cc2csc(COc3cccc(C)c3)n2)cc1,amide
+55864,Please remove a benzene_ring from the molecule CCC(CC)S(=O)(=O)/N=C(\[O-])c1ccc(N2CCOCC2)c(F)c1.,CCC(CC)S(=O)(=O)/N=C(\[O-])c1ccc(N2CCOCC2)c(F)c1,benzene_ring
+34252,Remove a amide from the molecule CC(C)NC(=O)c1cccc2c1NC(=O)C2.,CC(C)NC(=O)c1cccc2c1NC(=O)C2,amide
+231875,Remove a benzene_ring from the molecule CCOC(=O)C1CCN([C@H]2CS(=O)(=O)C[C@@H]2S(=O)(=O)c2ccc(OC)c(C)c2)CC1.,CCOC(=O)C1CCN([C@H]2CS(=O)(=O)C[C@@H]2S(=O)(=O)c2ccc(OC)c(C)c2)CC1,benzene_ring
+121147,Modify the molecule Cc1c(Cl)cccc1-n1ccc2nc(N3CCCCC3)ncc2c1=O by removing a benzene_ring.,Cc1c(Cl)cccc1-n1ccc2nc(N3CCCCC3)ncc2c1=O,benzene_ring
+70297,Please remove a halo from the molecule O=C(NC[C@@H]1CCN(c2ccc(F)c(F)c2)C1)N1CCC2(CC1)OCCO2.,O=C(NC[C@@H]1CCN(c2ccc(F)c(F)c2)C1)N1CCC2(CC1)OCCO2,halo
+20542,Remove a amide from the molecule Cc1cnc(C(=O)NCc2cnn(Cc3ccccc3)c2)cn1.,Cc1cnc(C(=O)NCc2cnn(Cc3ccccc3)c2)cn1,amide
+218115,Modify the molecule C[C@H](NC(=O)CCc1nc(-c2ccccn2)no1)c1ccc2c(c1)CCCO2 by removing a amide.,C[C@H](NC(=O)CCc1nc(-c2ccccn2)no1)c1ccc2c(c1)CCCO2,amide
+225473,Modify the molecule CC[C@H](C)[C@@H](NC(=O)/C=C/c1csc(C)n1)C(=O)[O-] by removing a amide.,CC[C@H](C)[C@@H](NC(=O)/C=C/c1csc(C)n1)C(=O)[O-],amide
+111107,Please remove a hydroxyl from the molecule Cc1ccc[nH+]c1N1CCN(C(=O)C[NH+]2CCC[C@H](O)C2)CC1.,Cc1ccc[nH+]c1N1CCN(C(=O)C[NH+]2CCC[C@H](O)C2)CC1,hydroxyl
+72539,Please remove a halo from the molecule FC(F)(F)c1ccccc1N[C@H]1CCO[C@]2(CCSC2)C1.,FC(F)(F)c1ccccc1N[C@H]1CCO[C@]2(CCSC2)C1,halo
+215394,Modify the molecule COc1ccc(-c2nnsc2C(=O)Nc2ccc(Br)cc2F)cc1 by removing a benzene_ring.,COc1ccc(-c2nnsc2C(=O)Nc2ccc(Br)cc2F)cc1,benzene_ring
+137755,Please remove a benzene_ring from the molecule CCOc1ccccc1NC(=O)NC[C@H](O)c1ccccc1F.,CCOc1ccccc1NC(=O)NC[C@H](O)c1ccccc1F,benzene_ring
+246819,Modify the molecule Cc1ccc(Cl)cc1NC(=O)c1ccc(-n2ccnc2)cc1 by removing a benzene_ring.,Cc1ccc(Cl)cc1NC(=O)c1ccc(-n2ccnc2)cc1,benzene_ring
+169121,Remove a amide from the molecule Cc1cc(C(=O)Nc2nnc(C3CCCCC3)s2)no1.,Cc1cc(C(=O)Nc2nnc(C3CCCCC3)s2)no1,amide
+89966,Modify the molecule CN(c1nc2ccc([N+](=O)[O-])cc2o1)[C@@H]1CC[NH2+]C1 by removing a nitro.,CN(c1nc2ccc([N+](=O)[O-])cc2o1)[C@@H]1CC[NH2+]C1,nitro
+167311,Please remove a amide from the molecule COc1ccccc1N1CC[NH+](C/C=C\c2ccc3c(c2)CCC(=O)N3)CC1.,COc1ccccc1N1CC[NH+](C/C=C\c2ccc3c(c2)CCC(=O)N3)CC1,amide
+151009,Modify the molecule CC1(C)NC(=O)N(CC(=O)NCCc2nc3ccccc3[nH]2)C1=O by removing a amide.,CC1(C)NC(=O)N(CC(=O)NCCc2nc3ccccc3[nH]2)C1=O,amide
+164175,Modify the molecule CCOc1ccc(NC(=O)CN2CC[NH+]([C@@H]3CC[C@H](CC)C3)CC2)cc1 by removing a benzene_ring.,CCOc1ccc(NC(=O)CN2CC[NH+]([C@@H]3CC[C@H](CC)C3)CC2)cc1,benzene_ring
+49848,Remove a benzene_ring from the molecule Cc1cc(NC(=O)Nc2ccccc2)c2ccccc2n1.,Cc1cc(NC(=O)Nc2ccccc2)c2ccccc2n1,benzene_ring
+61815,Please remove a benzene_ring from the molecule C[C@@H]1CC(Nc2cccc(Oc3cnccn3)c2)C[C@@H](C)O1.,C[C@@H]1CC(Nc2cccc(Oc3cnccn3)c2)C[C@@H](C)O1,benzene_ring
+107109,Modify the molecule CCN(c1ccccc1[C@H](C)[NH3+])C(C)C by removing a benzene_ring.,CCN(c1ccccc1[C@H](C)[NH3+])C(C)C,benzene_ring
+62605,Modify the molecule CC(=O)NC12C[C@H]3C[C@@H](C1)CC(C(=O)NCCCC1CCCC1)(C3)C2 by removing a amide.,CC(=O)NC12C[C@H]3C[C@@H](C1)CC(C(=O)NCCCC1CCCC1)(C3)C2,amide
+16629,Remove a amine from the molecule CC1(C)S[C@@H](c2ncc(-c3cccs3)s2)N[C@@H]1C(=O)[O-].,CC1(C)S[C@@H](c2ncc(-c3cccs3)s2)N[C@@H]1C(=O)[O-],amine
+181279,Please remove a benzene_ring from the molecule O=C(NCC[C@H]1CCCO1)c1ccc(Cl)cc1F.,O=C(NCC[C@H]1CCCO1)c1ccc(Cl)cc1F,benzene_ring
+144154,Please remove a amide from the molecule CCN1C(=O)c2ccc(Cl)cc2N[C@@H]1c1ccccc1[N+](=O)[O-].,CCN1C(=O)c2ccc(Cl)cc2N[C@@H]1c1ccccc1[N+](=O)[O-],amide
+26350,Please remove a amide from the molecule C[NH+]1CCN(C(=O)c2ccccc2NC(=S)NC(=O)c2ccco2)CC1.,C[NH+]1CCN(C(=O)c2ccccc2NC(=S)NC(=O)c2ccco2)CC1,amide
+184584,Remove a amine from the molecule C[C@H]1C[C@H](N)C[NH+](Cc2nnc(C(C)(C)C)o2)C1.,C[C@H]1C[C@H](N)C[NH+](Cc2nnc(C(C)(C)C)o2)C1,amine
+97804,Modify the molecule Cn1[nH]c(-c2ccc(Oc3ccccc3)cc2)cc1=O by removing a benzene_ring.,Cn1[nH]c(-c2ccc(Oc3ccccc3)cc2)cc1=O,benzene_ring
+74158,Please remove a amine from the molecule Cc1cc2c(c(=O)n1CCc1ccccc1)[C@H](c1ccc([N+](=O)[O-])o1)C(C#N)=C(N)O2.,Cc1cc2c(c(=O)n1CCc1ccccc1)[C@H](c1ccc([N+](=O)[O-])o1)C(C#N)=C(N)O2,amine
+84716,Remove a benzene_ring from the molecule CCOC(=O)c1cccc(NC(=O)N[C@@H](C)c2ccc(C)o2)c1.,CCOC(=O)c1cccc(NC(=O)N[C@@H](C)c2ccc(C)o2)c1,benzene_ring
+151627,Remove a amide from the molecule COc1ccnc(NC(=O)[C@]2(C)CC2(Cl)Cl)c1.,COc1ccnc(NC(=O)[C@]2(C)CC2(Cl)Cl)c1,amide
+155885,Please remove a benzene_ring from the molecule C[C@@H]([NH3+])c1cc(F)ccc1OCC[C@@H]1CCCO1.,C[C@@H]([NH3+])c1cc(F)ccc1OCC[C@@H]1CCCO1,benzene_ring
+105199,Modify the molecule C[C@H]1OCC[C@@H]1Nc1ccc(OC(F)F)cn1 by removing a halo.,C[C@H]1OCC[C@@H]1Nc1ccc(OC(F)F)cn1,halo
+66983,Please remove a halo from the molecule O=C(CCn1ccc2c(Cl)cccc21)NCc1nnc2ccccn12.,O=C(CCn1ccc2c(Cl)cccc21)NCc1nnc2ccccn12,halo
+11089,Please remove a amide from the molecule C[C@H]1C[NH+](Cc2ccccc2)CCCN1C(=O)CCn1ccccc1=O.,C[C@H]1C[NH+](Cc2ccccc2)CCCN1C(=O)CCn1ccccc1=O,amide
+210144,Remove a amine from the molecule Cc1ccccc1C(=O)OCCn1c(N)c(S(=O)(=O)c2ccccc2)c2nc3ccccc3nc21.,Cc1ccccc1C(=O)OCCn1c(N)c(S(=O)(=O)c2ccccc2)c2nc3ccccc3nc21,amine
+232147,Please remove a amine from the molecule COC[C@@H](N[C@H](C)c1nc2c(s1)CCCC2)c1ccco1.,COC[C@@H](N[C@H](C)c1nc2c(s1)CCCC2)c1ccco1,amine
+84521,Modify the molecule Cc1ccc(-c2c(-c3nn(C)c4ncnc(N5CC[C@H]([NH+]6CCCCC6)C5)c34)cnn2C)cc1 by removing a benzene_ring.,Cc1ccc(-c2c(-c3nn(C)c4ncnc(N5CC[C@H]([NH+]6CCCCC6)C5)c34)cnn2C)cc1,benzene_ring
+192188,Remove a hydroxyl from the molecule COc1ccc([C@@H]2OC(=O)N(C)[C@@]2(O)c2ccc(OC)cc2)cc1.,COc1ccc([C@@H]2OC(=O)N(C)[C@@]2(O)c2ccc(OC)cc2)cc1,hydroxyl
+113395,Modify the molecule CC[C@H](NC(=O)CC[C@H]1CCCOC1)c1cccc([N+](=O)[O-])c1 by removing a benzene_ring.,CC[C@H](NC(=O)CC[C@H]1CCCOC1)c1cccc([N+](=O)[O-])c1,benzene_ring
+233028,Remove a halo from the molecule Cc1ccc(NC(=O)C(=O)NC[C@H](c2cccn2C)[NH+](C)C)cc1F.,Cc1ccc(NC(=O)C(=O)NC[C@H](c2cccn2C)[NH+](C)C)cc1F,halo
+158958,Please remove a halo from the molecule C[C@@H](Sc1nccn1C)C(=O)Nc1ccc(OC(F)F)c(Cl)c1.,C[C@@H](Sc1nccn1C)C(=O)Nc1ccc(OC(F)F)c(Cl)c1,halo
+96852,Modify the molecule CC(C)(C)c1csc(CN2CCN(C(=O)/C=C/c3ccc4c(c3)OCO4)CC2)n1 by removing a amide.,CC(C)(C)c1csc(CN2CCN(C(=O)/C=C/c3ccc4c(c3)OCO4)CC2)n1,amide
+68702,Please remove a amine from the molecule Nc1ccccc1NC(=O)N[C@H]1CCOC1.,Nc1ccccc1NC(=O)N[C@H]1CCOC1,amine
+71723,Remove a amide from the molecule COc1ccccc1/C=C/C(=O)N1CCC(NS(C)(=O)=O)CC1.,COc1ccccc1/C=C/C(=O)N1CCC(NS(C)(=O)=O)CC1,amide
+82222,Modify the molecule Cc1ccc([C@@]2(C)NC(=O)N(CC(=O)N(C3CCCC3)[C@@H]3CCS(=O)(=O)C3)C2=O)cc1 by removing a benzene_ring.,Cc1ccc([C@@]2(C)NC(=O)N(CC(=O)N(C3CCCC3)[C@@H]3CCS(=O)(=O)C3)C2=O)cc1,benzene_ring
+145879,Modify the molecule O=C(Cc1c(Cl)cccc1Cl)C[C@@H]1C[C@H]2CC[C@@H]1C2 by removing a benzene_ring.,O=C(Cc1c(Cl)cccc1Cl)C[C@@H]1C[C@H]2CC[C@@H]1C2,benzene_ring
+91508,Remove a benzene_ring from the molecule COc1ccc(F)c(NC(=O)NCc2ccc3c(c2)CCC3)c1.,COc1ccc(F)c(NC(=O)NCc2ccc3c(c2)CCC3)c1,benzene_ring
+248955,Please remove a benzene_ring from the molecule S=C(CC12CC3CC(CC(C3)C1)C2)N1CCN(c2ccccc2)CC1.,S=C(CC12CC3CC(CC(C3)C1)C2)N1CCN(c2ccccc2)CC1,benzene_ring
+248337,Please remove a benzene_ring from the molecule Cc1noc(C)c1S(=O)(=O)Nc1cccc(-c2ccc(=O)n(C)n2)c1.,Cc1noc(C)c1S(=O)(=O)Nc1cccc(-c2ccc(=O)n(C)n2)c1,benzene_ring
+115988,Please remove a benzene_ring from the molecule O=c1c2cc([N+](=O)[O-])ccc2ncn1Cc1cccc(Cl)c1.,O=c1c2cc([N+](=O)[O-])ccc2ncn1Cc1cccc(Cl)c1,benzene_ring
+233689,Modify the molecule O=C(c1ccccc1-c1ccccc1)N1CCC[NH+](C[C@H]2CCCO2)CC1 by removing a benzene_ring.,O=C(c1ccccc1-c1ccccc1)N1CCC[NH+](C[C@H]2CCCO2)CC1,benzene_ring
+91396,Modify the molecule Cc1ccc(C)c(NC(=O)[C@@H](C)S(=O)(=O)[C@@H](C)C(C)C)c1 by removing a amide.,Cc1ccc(C)c(NC(=O)[C@@H](C)S(=O)(=O)[C@@H](C)C(C)C)c1,amide
+109839,Please remove a amide from the molecule N#CCNC(=O)C[NH+]1CCCN(S(=O)(=O)c2ccc(F)cc2)CC1.,N#CCNC(=O)C[NH+]1CCCN(S(=O)(=O)c2ccc(F)cc2)CC1,amide
+150489,Remove a benzene_ring from the molecule Cc1ccccc1NC(=O)c1c(C)nc(Nc2nc3ccccc3o2)nc1C.,Cc1ccccc1NC(=O)c1c(C)nc(Nc2nc3ccccc3o2)nc1C,benzene_ring
+27465,Remove a halo from the molecule COc1cc(Br)c(N)c(C(=O)[O-])c1.,COc1cc(Br)c(N)c(C(=O)[O-])c1,halo
+144011,Modify the molecule Cc1ccc(NC(=O)c2ccccc2C)c(Nc2ccco2)c1 by removing a amine.,Cc1ccc(NC(=O)c2ccccc2C)c(Nc2ccco2)c1,amine
+57009,Modify the molecule Cc1cc(C)cc(N2CC[C@H](NC(=O)c3cc(F)ccc3F)C2=O)c1 by removing a benzene_ring.,Cc1cc(C)cc(N2CC[C@H](NC(=O)c3cc(F)ccc3F)C2=O)c1,benzene_ring
+24225,Modify the molecule C[C@@H](CC(=O)N1CCN(S(=O)(=O)c2cccc(Cl)c2Cl)CC1)c1ccccc1 by removing a benzene_ring.,C[C@@H](CC(=O)N1CCN(S(=O)(=O)c2cccc(Cl)c2Cl)CC1)c1ccccc1,benzene_ring
+121713,Modify the molecule Cc1nnc(NC(=O)c2cc(=O)c3ccccc3o2)s1 by removing a amide.,Cc1nnc(NC(=O)c2cc(=O)c3ccccc3o2)s1,amide
+2044,Remove a benzene_ring from the molecule COc1ccc(NC(=O)NCC(=O)[O-])cc1Cl.,COc1ccc(NC(=O)NCC(=O)[O-])cc1Cl,benzene_ring
+101555,Please remove a benzene_ring from the molecule CC[C@H](NC(=O)Nc1ccn(C)n1)c1ccc(C)cc1.,CC[C@H](NC(=O)Nc1ccn(C)n1)c1ccc(C)cc1,benzene_ring
+48932,Please remove a benzene_ring from the molecule Cc1cccc(N2C(=O)[C@@H]3[C@H](c4ccccc4)OC4(C(=O)c5ccccc5C4=O)[C@@H]3C2=O)c1C.,Cc1cccc(N2C(=O)[C@@H]3[C@H](c4ccccc4)OC4(C(=O)c5ccccc5C4=O)[C@@H]3C2=O)c1C,benzene_ring
+229011,Remove a benzene_ring from the molecule COc1cc(C#N)ccc1OCC(=O)Nc1ccc(C(C)=O)cc1.,COc1cc(C#N)ccc1OCC(=O)Nc1ccc(C(C)=O)cc1,benzene_ring
+156761,Modify the molecule CC(C)c1ccc([C@@H](Cl)[C@H](C)c2ccccn2)cc1 by removing a benzene_ring.,CC(C)c1ccc([C@@H](Cl)[C@H](C)c2ccccn2)cc1,benzene_ring
+52847,Modify the molecule N=[S@](N)c1cnc(N)s1 by removing a amine.,N=[S@](N)c1cnc(N)s1,amine
+30339,Modify the molecule C=CCNc1ccc([N+](=O)[O-])c(N)n1 by removing a nitro.,C=CCNc1ccc([N+](=O)[O-])c(N)n1,nitro
+158546,Please remove a amine from the molecule Nc1ccc(F)cc1NC(=O)COCc1ccco1.,Nc1ccc(F)cc1NC(=O)COCc1ccco1,amine
+192015,Modify the molecule CC1CC[NH+](CCNC(=O)C(=O)Nc2cc(F)cc(F)c2)CC1 by removing a halo.,CC1CC[NH+](CCNC(=O)C(=O)Nc2cc(F)cc(F)c2)CC1,halo
+125566,Modify the molecule Cc1cc(F)ccc1CCNC(=O)NCCCn1nc2n(c1=O)CCCC2 by removing a benzene_ring.,Cc1cc(F)ccc1CCNC(=O)NCCCn1nc2n(c1=O)CCCC2,benzene_ring
+122996,Modify the molecule COc1ccccc1OC(=O)CCc1c(C)nc(-c2cccnc2)[nH]c1=O by removing a benzene_ring.,COc1ccccc1OC(=O)CCc1c(C)nc(-c2cccnc2)[nH]c1=O,benzene_ring
+101683,Modify the molecule COc1cc([C@@H]2NC(=O)N(C)[C@@](O)(C(F)(F)F)[C@H]2C(=O)c2cccs2)cc(OC)c1OC by removing a halo.,COc1cc([C@@H]2NC(=O)N(C)[C@@](O)(C(F)(F)F)[C@H]2C(=O)c2cccs2)cc(OC)c1OC,halo
+188342,Modify the molecule O=C(NCc1cccnc1)C(F)(F)F by removing a amide.,O=C(NCc1cccnc1)C(F)(F)F,amide
+221211,Remove a amide from the molecule Cn1c(SCC(=O)Nc2ccc3c(c2)OCCO3)nc2c([nH]c3ccccc32)c1=O.,Cn1c(SCC(=O)Nc2ccc3c(c2)OCCO3)nc2c([nH]c3ccccc32)c1=O,amide
+66973,Please remove a hydroxyl from the molecule Oc1ccc(-c2nc3ccccc3s2)cc1Cl.,Oc1ccc(-c2nc3ccccc3s2)cc1Cl,hydroxyl
+12689,Please remove a benzene_ring from the molecule Cc1cc(C)cc(C(=O)N2CC[C@H](C(=O)[O-])[C@@H]2C)c1.,Cc1cc(C)cc(C(=O)N2CC[C@H](C(=O)[O-])[C@@H]2C)c1,benzene_ring
+204060,Modify the molecule Cc1cn(-c2ccccc2Cl)nc1NC(=O)C(=O)NCCCC(C)(C)C by removing a benzene_ring.,Cc1cn(-c2ccccc2Cl)nc1NC(=O)C(=O)NCCCC(C)(C)C,benzene_ring
+119770,Please remove a benzene_ring from the molecule O=C(NC1CCN(c2ncc(Cl)cc2F)CC1)c1ccccc1F.,O=C(NC1CCN(c2ncc(Cl)cc2F)CC1)c1ccccc1F,benzene_ring
+4401,Remove a benzene_ring from the molecule COc1cccc([C@H]2C[C@H]2C(=O)Oc2cccc(-n3cccn3)c2)c1.,COc1cccc([C@H]2C[C@H]2C(=O)Oc2cccc(-n3cccn3)c2)c1,benzene_ring
+133645,Modify the molecule Cc1ccc2c(c1)cc(C(=O)N(Cc1ccccn1)C1CCCCC1)n2C by removing a amide.,Cc1ccc2c(c1)cc(C(=O)N(Cc1ccccn1)C1CCCCC1)n2C,amide
+176505,Remove a benzene_ring from the molecule COc1ccc(N(C)S(=O)(=O)c2cccc(C(=O)N[C@H]3CCCC[C@H]3C)c2)cc1.,COc1ccc(N(C)S(=O)(=O)c2cccc(C(=O)N[C@H]3CCCC[C@H]3C)c2)cc1,benzene_ring
+177509,Remove a halo from the molecule COc1ccc(N2CCN([C@H](c3ccccc3F)c3nnnn3C3CCCCC3)CC2)cc1.,COc1ccc(N2CCN([C@H](c3ccccc3F)c3nnnn3C3CCCCC3)CC2)cc1,halo
+108441,Please remove a amide from the molecule Cc1cccc(NC(=O)c2cccc(NC(=O)C(C)(C)C)c2)c1C.,Cc1cccc(NC(=O)c2cccc(NC(=O)C(C)(C)C)c2)c1C,amide
+92852,Remove a aldehyde from the molecule CC/C(C=O)=C\C1CCCCCC1.,CC/C(C=O)=C\C1CCCCCC1,aldehyde
+1575,Modify the molecule Cc1nn(-c2ccccc2)c(C)c1S(=O)(=O)N1CCCCCC1 by removing a benzene_ring.,Cc1nn(-c2ccccc2)c(C)c1S(=O)(=O)N1CCCCCC1,benzene_ring
+30720,Please remove a amine from the molecule CCN1C(N)=[NH+]C[C@@]1(C)c1ccc2cc(OC)ccc2c1.,CCN1C(N)=[NH+]C[C@@]1(C)c1ccc2cc(OC)ccc2c1,amine
+204412,Remove a benzene_ring from the molecule Cc1ccc(C(=O)C(=O)N2CCOCC[C@H]2C)cc1.,Cc1ccc(C(=O)C(=O)N2CCOCC[C@H]2C)cc1,benzene_ring
+225288,Please remove a amide from the molecule CCOc1ccc(CC(=O)Nc2ccc(S(N)(=O)=O)c(C)c2)cc1.,CCOc1ccc(CC(=O)Nc2ccc(S(N)(=O)=O)c(C)c2)cc1,amide
+48714,Please remove a benzene_ring from the molecule CC[C@@H]1SC2=NC(C)=C(C(=O)OCC(C)C)[C@H](c3ccc(OC)cc3)N2C1=O.,CC[C@@H]1SC2=NC(C)=C(C(=O)OCC(C)C)[C@H](c3ccc(OC)cc3)N2C1=O,benzene_ring
+212527,Modify the molecule O=C(Nc1ccc(N2CCN(C(=O)c3ccco3)CC2)cc1)c1ccc(-c2ccccc2[N+](=O)[O-])o1 by removing a nitro.,O=C(Nc1ccc(N2CCN(C(=O)c3ccco3)CC2)cc1)c1ccc(-c2ccccc2[N+](=O)[O-])o1,nitro
+95756,Modify the molecule Cc1nc2c(sc3nc(-c4ccccc4)ccc32)c(=O)n1CC(=O)NCc1ccccc1 by removing a amide.,Cc1nc2c(sc3nc(-c4ccccc4)ccc32)c(=O)n1CC(=O)NCc1ccccc1,amide
+45558,Please remove a halo from the molecule COc1cc(NC(=O)[C@@H]2CC(=O)N(C)C2)c(OC)cc1Cl.,COc1cc(NC(=O)[C@@H]2CC(=O)N(C)C2)c(OC)cc1Cl,halo
+247821,Please remove a halo from the molecule Cc1nc(C(=O)N(C)Cc2ccc(C(F)(F)F)cc2)nn1-c1ccc(F)cc1.,Cc1nc(C(=O)N(C)Cc2ccc(C(F)(F)F)cc2)nn1-c1ccc(F)cc1,halo
+197053,Please remove a halo from the molecule O=C(Cc1ccc(F)cc1)Nc1cccc(-c2cn3c(C(=O)N4CCOCC4)csc3n2)c1.,O=C(Cc1ccc(F)cc1)Nc1cccc(-c2cn3c(C(=O)N4CCOCC4)csc3n2)c1,halo
+51403,Please remove a amide from the molecule CC(=O)N[C@H](c1nccs1)C1CCN(C(=O)c2c(C(C)C)noc2C)CC1.,CC(=O)N[C@H](c1nccs1)C1CCN(C(=O)c2c(C(C)C)noc2C)CC1,amide
+234246,Modify the molecule Cc1cnn([C@@H]2CCCN(C(=O)CN3C(=O)CNC3=O)C2)c1 by removing a amide.,Cc1cnn([C@@H]2CCCN(C(=O)CN3C(=O)CNC3=O)C2)c1,amide
+15707,Please remove a halo from the molecule CC(C)CCO[C@@H]1CCN(C(=O)[C@H](C)NC(=O)c2ccc(Cl)cc2)C1.,CC(C)CCO[C@@H]1CCN(C(=O)[C@H](C)NC(=O)c2ccc(Cl)cc2)C1,halo
+94932,Modify the molecule O=C(Nc1cnn(-c2ccccc2F)c1)N1CCSCC1 by removing a benzene_ring.,O=C(Nc1cnn(-c2ccccc2F)c1)N1CCSCC1,benzene_ring
+35884,Modify the molecule C[NH+](C)[C@@H]1CCCN(Cc2cc(C(N)=O)cs2)C1 by removing a amide.,C[NH+](C)[C@@H]1CCCN(Cc2cc(C(N)=O)cs2)C1,amide
+129183,Remove a amide from the molecule C[C@@H](C(=O)Nc1ccc(Br)cc1Br)[NH+](C)C[C@@H]1COc2ccccc2O1.,C[C@@H](C(=O)Nc1ccc(Br)cc1Br)[NH+](C)C[C@@H]1COc2ccccc2O1,amide
+36008,Modify the molecule O=C(Nc1ccccc1)C(=O)Nc1cc(-n2cccc2)ccc1F by removing a halo.,O=C(Nc1ccccc1)C(=O)Nc1cc(-n2cccc2)ccc1F,halo
+193161,Modify the molecule C[C@H]1CN(c2cncc(C(N)=O)n2)CCO1 by removing a amide.,C[C@H]1CN(c2cncc(C(N)=O)n2)CCO1,amide
+209011,Please remove a amide from the molecule COc1ccc(F)c(NC(=O)C(=O)NCCN(C)c2ccccc2)c1.,COc1ccc(F)c(NC(=O)C(=O)NCCN(C)c2ccccc2)c1,amide
+26521,Please remove a benzene_ring from the molecule C=CCn1c(=O)c2c(nc3n2CCN3c2ccc(CC)cc2)n(C)c1=O.,C=CCn1c(=O)c2c(nc3n2CCN3c2ccc(CC)cc2)n(C)c1=O,benzene_ring
+154525,Remove a amide from the molecule Cc1ccc(C2=C[C@H]([C@H]3NN[C@H](SCC(=O)Nc4cccc(C(F)(F)F)c4)N3N)N=N2)cc1.,Cc1ccc(C2=C[C@H]([C@H]3NN[C@H](SCC(=O)Nc4cccc(C(F)(F)F)c4)N3N)N=N2)cc1,amide
+3056,Please remove a hydroxyl from the molecule CCC[NH2+]CC[NH+](C)CC(C)(C)O.,CCC[NH2+]CC[NH+](C)CC(C)(C)O,hydroxyl
+5319,Please remove a hydroxyl from the molecule CC1(C)C[C@](O)([C@@H]2CCOC3(CCC3)C2)CCO1.,CC1(C)C[C@](O)([C@@H]2CCOC3(CCC3)C2)CCO1,hydroxyl
+65375,Modify the molecule NC(=O)C1CCN(CCC[NH2+]Cc2ccc3ccccc3c2)CC1 by removing a amide.,NC(=O)C1CCN(CCC[NH2+]Cc2ccc3ccccc3c2)CC1,amide
+231713,Modify the molecule C[C@H](NS(=O)(=O)c1cccc(F)c1)C(=O)N1CCCC1 by removing a amine.,C[C@H](NS(=O)(=O)c1cccc(F)c1)C(=O)N1CCCC1,amine
+16480,Remove a amine from the molecule CCOC(=O)NC1=c2c(OC)cccc2=[NH+][C@H]1C(=O)OC.,CCOC(=O)NC1=c2c(OC)cccc2=[NH+][C@H]1C(=O)OC,amine
+201571,Please remove a amide from the molecule CCc1ccccc1N1C[C@H](C(=O)NC[C@@H](C)Cn2cccn2)CC1=O.,CCc1ccccc1N1C[C@H](C(=O)NC[C@@H](C)Cn2cccn2)CC1=O,amide
+157316,Modify the molecule [NH3+][C@H](c1cccc(F)c1)[C@@H]1CCOC2(CCC2)C1 by removing a halo.,[NH3+][C@H](c1cccc(F)c1)[C@@H]1CCOC2(CCC2)C1,halo
+107757,Modify the molecule COc1cccc(S(=O)(=O)/N=C(\[O-])CCn2cc(C)cn2)c1 by removing a benzene_ring.,COc1cccc(S(=O)(=O)/N=C(\[O-])CCn2cc(C)cn2)c1,benzene_ring
+114051,Please remove a benzene_ring from the molecule CC[C@H](CC1CCCC1)C(=O)Nc1cc(C(=O)N(C)C)ccc1C.,CC[C@H](CC1CCCC1)C(=O)Nc1cc(C(=O)N(C)C)ccc1C,benzene_ring
+241547,Remove a benzene_ring from the molecule COc1ccc(OC)c(N2CCN(CC(=O)NCc3c(F)cccc3F)C2=O)c1.,COc1ccc(OC)c(N2CCN(CC(=O)NCc3c(F)cccc3F)C2=O)c1,benzene_ring
+220034,Remove a amine from the molecule CCOc1ccccc1[C@H]1C2=C(CCCC2=O)Nc2onc(C)c21.,CCOc1ccccc1[C@H]1C2=C(CCCC2=O)Nc2onc(C)c21,amine
+72735,Remove a halo from the molecule Cc1cc(F)cc(Nc2c(N)ccc(F)c2F)c1.,Cc1cc(F)cc(Nc2c(N)ccc(F)c2F)c1,halo
+98798,Please remove a benzene_ring from the molecule C[NH+](C)C[C@H](Cc1ccccc1)NC(=O)[C@H]1CCC[NH+](C)C1.,C[NH+](C)C[C@H](Cc1ccccc1)NC(=O)[C@H]1CCC[NH+](C)C1,benzene_ring
+142178,Please remove a hydroxyl from the molecule CC1(C)CC(NC(=O)NC[C@@H]2CCC[C@@H](O)C2)CC(C)(C)[NH2+]1.,CC1(C)CC(NC(=O)NC[C@@H]2CCC[C@@H](O)C2)CC(C)(C)[NH2+]1,hydroxyl
+9647,Remove a halo from the molecule Cc1nn(C)c(Cl)c1[C@@H]1CCC[NH+]1CCCS(C)(=O)=O.,Cc1nn(C)c(Cl)c1[C@@H]1CCC[NH+]1CCCS(C)(=O)=O,halo
+81314,Modify the molecule COc1cccc2cc(NC(=O)c3ccccc3)c(=O)oc12 by removing a benzene_ring.,COc1cccc2cc(NC(=O)c3ccccc3)c(=O)oc12,benzene_ring
+53179,Remove a benzene_ring from the molecule O=C(O[C@H](c1ccccc1)c1nccs1)c1cccc2c1OCO2.,O=C(O[C@H](c1ccccc1)c1nccs1)c1cccc2c1OCO2,benzene_ring
+168894,Remove a amide from the molecule CC(C)[C@H](NC(=O)c1cc(C(N)=O)cn1C)c1nnc2ccccn12.,CC(C)[C@H](NC(=O)c1cc(C(N)=O)cn1C)c1nnc2ccccn12,amide
+99121,Modify the molecule CC(C)n1c(CC(=O)Nc2ccccc2F)n[nH]c1=S by removing a amide.,CC(C)n1c(CC(=O)Nc2ccccc2F)n[nH]c1=S,amide
+218110,Please remove a benzene_ring from the molecule CC(C)C[NH2+]Cc1ncoc1-c1ccc(C(C)(C)C)cc1.,CC(C)C[NH2+]Cc1ncoc1-c1ccc(C(C)(C)C)cc1,benzene_ring
+132672,Modify the molecule C[C@@H](C(=O)Nc1cccc(C(F)(F)F)c1)N1CC[NH+](C)CC1 by removing a amide.,C[C@@H](C(=O)Nc1cccc(C(F)(F)F)c1)N1CC[NH+](C)CC1,amide
+178288,Please remove a benzene_ring from the molecule COC(=O)c1ccc(NC(=O)CN2C(=O)[C@@H]3[C@H](C2=O)[C@@H]2C=C[C@H]3[C@@H]3C[C@H]23)cc1.,COC(=O)c1ccc(NC(=O)CN2C(=O)[C@@H]3[C@H](C2=O)[C@@H]2C=C[C@H]3[C@@H]3C[C@H]23)cc1,benzene_ring
+176026,Please remove a amine from the molecule O=C(NNS(=O)(=O)c1ccc2c(c1)CCC2)c1ccc2ccccc2n1.,O=C(NNS(=O)(=O)c1ccc2c(c1)CCC2)c1ccc2ccccc2n1,amine
+77868,Please remove a halo from the molecule CC[C@@H](CSC)N(C)C(=O)N[C@H]1CCCc2ccc(F)cc21.,CC[C@@H](CSC)N(C)C(=O)N[C@H]1CCCc2ccc(F)cc21,halo
+194305,Please remove a benzene_ring from the molecule CN(Cc1ccc(F)cc1F)C(=O)Cc1c(F)cccc1F.,CN(Cc1ccc(F)cc1F)C(=O)Cc1c(F)cccc1F,benzene_ring
+207999,Please remove a amide from the molecule O=C([C@H]1Cc2ccccc2S1)N1C[C@H]2C[NH2+]C[C@@H]2C1.,O=C([C@H]1Cc2ccccc2S1)N1C[C@H]2C[NH2+]C[C@@H]2C1,amide
+104866,Modify the molecule COc1ccc([C@]2(C)NC(=O)N(CC(=O)NCc3ccco3)C2=O)cc1 by removing a benzene_ring.,COc1ccc([C@]2(C)NC(=O)N(CC(=O)NCc3ccco3)C2=O)cc1,benzene_ring
+231401,Remove a benzene_ring from the molecule Cc1ccccc1-c1noc(C2CCN(S(=O)(=O)c3cccs3)CC2)n1.,Cc1ccccc1-c1noc(C2CCN(S(=O)(=O)c3cccs3)CC2)n1,benzene_ring
+8638,Remove a amide from the molecule CCc1cccc(C(=O)N[C@H]2CCC[C@@H]2C(=O)OC)c1O.,CCc1cccc(C(=O)N[C@H]2CCC[C@@H]2C(=O)OC)c1O,amide
+63052,Remove a amine from the molecule Clc1cc2c(cc1NCc1nc3c(s1)CCC3)OCO2.,Clc1cc2c(cc1NCc1nc3c(s1)CCC3)OCO2,amine
+2803,Please remove a amide from the molecule COc1cc([C@@H]2NC(=O)c3cccnc3N2)ccc1O.,COc1cc([C@@H]2NC(=O)c3cccnc3N2)ccc1O,amide
+216816,Please remove a benzene_ring from the molecule O=C1NC2(CCCC2)C(=O)N1C[C@H](O)c1ccccc1C(F)(F)F.,O=C1NC2(CCCC2)C(=O)N1C[C@H](O)c1ccccc1C(F)(F)F,benzene_ring
+115691,Remove a benzene_ring from the molecule Cc1cscc1C(=O)Cc1ccc(I)cc1.,Cc1cscc1C(=O)Cc1ccc(I)cc1,benzene_ring
+22335,Please remove a amide from the molecule Cn1cc(CCC(=O)Nc2cc(-c3ccncc3)n[nH]2)cn1.,Cn1cc(CCC(=O)Nc2cc(-c3ccncc3)n[nH]2)cn1,amide
+19280,Modify the molecule CC(C)N(CC(=O)N1C[C@H](C)O[C@H](C)C1)c1ccc(F)cc1 by removing a benzene_ring.,CC(C)N(CC(=O)N1C[C@H](C)O[C@H](C)C1)c1ccc(F)cc1,benzene_ring
+160342,Please remove a benzene_ring from the molecule CNC(=O)c1cccc(NCc2cn(C)nc2-c2ccccc2)c1.,CNC(=O)c1cccc(NCc2cn(C)nc2-c2ccccc2)c1,benzene_ring
+127504,Please remove a amide from the molecule CCOc1ncccc1C(=O)Nc1cc(F)c(N(C)C)c(F)c1.,CCOc1ncccc1C(=O)Nc1cc(F)c(N(C)C)c(F)c1,amide
+232990,Remove a amide from the molecule CC[C@@](C)(NC(=O)c1cc(C)c(Br)s1)C(=O)[O-].,CC[C@@](C)(NC(=O)c1cc(C)c(Br)s1)C(=O)[O-],amide
+123613,Remove a amine from the molecule COc1ccc(C(=O)Nc2ccc(Cl)cc2N)cc1O.,COc1ccc(C(=O)Nc2ccc(Cl)cc2N)cc1O,amine
+208801,Modify the molecule CC(C)c1ccc(S(=O)(=O)N[C@@H](c2ccccc2F)c2nccn2C)cc1 by removing a amine.,CC(C)c1ccc(S(=O)(=O)N[C@@H](c2ccccc2F)c2nccn2C)cc1,amine
+24096,Modify the molecule Cc1ccc(NC(=O)N(C)C)c(C(=O)Nc2cccc(F)c2C)c1 by removing a benzene_ring.,Cc1ccc(NC(=O)N(C)C)c(C(=O)Nc2cccc(F)c2C)c1,benzene_ring
+137950,Modify the molecule O=C(O[C@@H](C(=O)NC1CC1)c1ccccc1)[C@H]1CC(=O)N(c2ccccc2F)C1 by removing a halo.,O=C(O[C@@H](C(=O)NC1CC1)c1ccccc1)[C@H]1CC(=O)N(c2ccccc2F)C1,halo
+92831,Modify the molecule NC(=O)c1ccc(NC(=O)CN2C(=O)N[C@]3(CCCc4ccccc43)C2=O)cc1 by removing a benzene_ring.,NC(=O)c1ccc(NC(=O)CN2C(=O)N[C@]3(CCCc4ccccc43)C2=O)cc1,benzene_ring
+34984,Please remove a amide from the molecule CC[C@H]1CCCC[C@H]1NC(=O)C(=O)Nc1cccc2cccnc12.,CC[C@H]1CCCC[C@H]1NC(=O)C(=O)Nc1cccc2cccnc12,amide
+7586,Modify the molecule CCCS(=O)(=O)N1CCN(S(=O)(=O)Cc2ccccc2)CC1 by removing a benzene_ring.,CCCS(=O)(=O)N1CCN(S(=O)(=O)Cc2ccccc2)CC1,benzene_ring
+52702,Please remove a amide from the molecule CNC(=O)c1ccc(CNC(=O)Nc2ccc(-c3csc(C)n3)cc2)cc1.,CNC(=O)c1ccc(CNC(=O)Nc2ccc(-c3csc(C)n3)cc2)cc1,amide
+196840,Remove a benzene_ring from the molecule Cc1ccc(CNS(C)(=O)=O)c(OC(C)(C)C)c1.,Cc1ccc(CNS(C)(=O)=O)c(OC(C)(C)C)c1,benzene_ring
+154802,Remove a benzene_ring from the molecule CSc1cccc(NC(=O)Cc2c(C)nc3cc(-c4ccccc4)nn3c2C)c1.,CSc1cccc(NC(=O)Cc2c(C)nc3cc(-c4ccccc4)nn3c2C)c1,benzene_ring
+80594,Modify the molecule C[C@@H]1OCC[C@H]1C(=O)N1CCCC[C@@H]1C[NH+](C)C by removing a amide.,C[C@@H]1OCC[C@H]1C(=O)N1CCCC[C@@H]1C[NH+](C)C,amide
+186201,Remove a amine from the molecule COC(=O)C[C@H](NS(=O)(=O)c1ccc(C)cc1)c1ccccc1.,COC(=O)C[C@H](NS(=O)(=O)c1ccc(C)cc1)c1ccccc1,amine
+229585,Please remove a amide from the molecule C[C@H]([NH3+])C(=O)NCC1C(C)(C)C1(C)C.,C[C@H]([NH3+])C(=O)NCC1C(C)(C)C1(C)C,amide
+230439,Modify the molecule COc1ccc(C(=O)N2CCN(c3nc4c(C)cccc4s3)CC2)c(OC)c1 by removing a benzene_ring.,COc1ccc(C(=O)N2CCN(c3nc4c(C)cccc4s3)CC2)c(OC)c1,benzene_ring
+13551,Please remove a halo from the molecule CCN(Cc1cccc(C)n1)C[C@H](Br)C(F)(F)F.,CCN(Cc1cccc(C)n1)C[C@H](Br)C(F)(F)F,halo
+80605,Please remove a benzene_ring from the molecule Cc1cc(OCc2ccccc2)nc(N2CCN(c3ccccc3)CC2)[nH+]1.,Cc1cc(OCc2ccccc2)nc(N2CCN(c3ccccc3)CC2)[nH+]1,benzene_ring
+151885,Remove a amine from the molecule Cc1ccc(-c2nnc(SCC(=O)Nc3nc(C)cs3)n2N)cc1.,Cc1ccc(-c2nnc(SCC(=O)Nc3nc(C)cs3)n2N)cc1,amine
+137107,Remove a amide from the molecule Cc1ccc([C@H](C)NC(=O)c2cc(C)c(C#CCN)s2)s1.,Cc1ccc([C@H](C)NC(=O)c2cc(C)c(C#CCN)s2)s1,amide
+168700,Modify the molecule CC[C@@H](c1ncc(Cl)cc1Cl)[C@H](C)[NH3+] by removing a halo.,CC[C@@H](c1ncc(Cl)cc1Cl)[C@H](C)[NH3+],halo
+19903,Modify the molecule CCOc1ccc([N-]S(=O)(=O)[C@H]2C(C)=NC(C)=C2C(=O)N2CCCCC2)cc1 by removing a amide.,CCOc1ccc([N-]S(=O)(=O)[C@H]2C(C)=NC(C)=C2C(=O)N2CCCCC2)cc1,amide
+71540,Modify the molecule COCCN1C[C@H](C(=O)Nc2cccnc2-n2cccn2)CC1=O by removing a amide.,COCCN1C[C@H](C(=O)Nc2cccnc2-n2cccn2)CC1=O,amide
+220352,Modify the molecule O=C(NCCc1cc(F)cc2c1OCOC2)NC[C@@H]1CCCO1 by removing a halo.,O=C(NCCc1cc(F)cc2c1OCOC2)NC[C@@H]1CCCO1,halo
+106534,Please remove a amide from the molecule CN1CCCCC/C1=N\S(=O)(=O)c1cccc(NC(=O)C2(C)CCCC2)c1.,CN1CCCCC/C1=N\S(=O)(=O)c1cccc(NC(=O)C2(C)CCCC2)c1,amide
+182228,Modify the molecule C[C@@H](C(=O)Nc1ccccc1-n1cnnn1)n1nnc(-c2ccccc2)n1 by removing a benzene_ring.,C[C@@H](C(=O)Nc1ccccc1-n1cnnn1)n1nnc(-c2ccccc2)n1,benzene_ring
+72311,Please remove a benzene_ring from the molecule CCC(C)(CC)NC(=O)Nc1ccc(C(=O)NCC(C)C)cc1.,CCC(C)(CC)NC(=O)Nc1ccc(C(=O)NCC(C)C)cc1,benzene_ring
+149447,Please remove a amide from the molecule O=C(Nc1cc(F)ccc1Cl)[C@@H]1CCCCN1C(=O)c1ccco1.,O=C(Nc1cc(F)ccc1Cl)[C@@H]1CCCCN1C(=O)c1ccco1,amide
+27234,Remove a amide from the molecule CCCNC(=O)C1CC[NH+](CCC(=O)Nc2ccc(Cl)cc2)CC1.,CCCNC(=O)C1CC[NH+](CCC(=O)Nc2ccc(Cl)cc2)CC1,amide
+206907,Remove a halo from the molecule C[C@H]1CCC[C@@H](NC(=O)COCC(F)(F)F)C1.,C[C@H]1CCC[C@@H](NC(=O)COCC(F)(F)F)C1,halo
+98029,Please remove a benzene_ring from the molecule CC(C)Cn1ccnc(N[C@@H]2CCO[C@@H]2c2ccc(Cl)cc2)c1=O.,CC(C)Cn1ccnc(N[C@@H]2CCO[C@@H]2c2ccc(Cl)cc2)c1=O,benzene_ring
+91605,Please remove a benzene_ring from the molecule O=C(Nc1cnn(-c2ccc(C(=O)N[C@@H]3CCC[NH+](Cc4ccccc4)C3)cc2)c1)c1cccnc1.,O=C(Nc1cnn(-c2ccc(C(=O)N[C@@H]3CCC[NH+](Cc4ccccc4)C3)cc2)c1)c1cccnc1,benzene_ring
+47351,Please remove a halo from the molecule O=S1(=O)c2cccc3cccc(c23)N1C[C@@H](O)COc1ccc(Cl)cc1Cl.,O=S1(=O)c2cccc3cccc(c23)N1C[C@@H](O)COc1ccc(Cl)cc1Cl,halo
+128315,Remove a nitro from the molecule O=C(c1ccc([N+](=O)[O-])o1)N1CCC(c2nc3ccccc3o2)CC1.,O=C(c1ccc([N+](=O)[O-])o1)N1CCC(c2nc3ccccc3o2)CC1,nitro
+50970,Please remove a benzene_ring from the molecule CCCN(CCO)C(=O)Nc1cccc(C(=O)Nc2cccc(C#N)c2)c1.,CCCN(CCO)C(=O)Nc1cccc(C(=O)Nc2cccc(C#N)c2)c1,benzene_ring
+130521,Modify the molecule COc1ccc(C(=O)C(/C=N\O)=N\Nc2ccc(F)cc2)cc1 by removing a halo.,COc1ccc(C(=O)C(/C=N\O)=N\Nc2ccc(F)cc2)cc1,halo
+54928,Please remove a benzene_ring from the molecule CC1(C)C[C@]2(C[C@H](c3ccccc3)Oc3cc(O)ccc32)[NH+]=C([S-])N1.,CC1(C)C[C@]2(C[C@H](c3ccccc3)Oc3cc(O)ccc32)[NH+]=C([S-])N1,benzene_ring
+237718,Remove a amide from the molecule COC(=O)c1ccc(F)c(NCc2cc(C(N)=O)cs2)c1.,COC(=O)c1ccc(F)c(NCc2cc(C(N)=O)cs2)c1,amide
+53927,Remove a halo from the molecule O=C(Cn1nc(-c2ccc(F)cc2)oc1=O)OCc1nc2ccccc2s1.,O=C(Cn1nc(-c2ccc(F)cc2)oc1=O)OCc1nc2ccccc2s1,halo
+207805,Remove a amide from the molecule Cc1[nH+]c([C@H]2CCCCN2C(=O)Cc2ccccn2)nc2c1CCCN2Cc1ccccc1.,Cc1[nH+]c([C@H]2CCCCN2C(=O)Cc2ccccn2)nc2c1CCCN2Cc1ccccc1,amide
+159281,Remove a amide from the molecule C[C@@H]1OCC[C@H]1C(=O)N(CC(=O)N1CCCC1)C[C@@H]1CCCO1.,C[C@@H]1OCC[C@H]1C(=O)N(CC(=O)N1CCCC1)C[C@@H]1CCCO1,amide
+180179,Modify the molecule O=C(CSc1ccc(F)cc1)NCc1n[nH]c(=O)c2ccccc12 by removing a halo.,O=C(CSc1ccc(F)cc1)NCc1n[nH]c(=O)c2ccccc12,halo
+146804,Remove a nitro from the molecule CNc1cc(CN(C)C[C@@H]2CC[NH+](C)C2)ccc1[N+](=O)[O-].,CNc1cc(CN(C)C[C@@H]2CC[NH+](C)C2)ccc1[N+](=O)[O-],nitro
+213064,Remove a benzene_ring from the molecule C=C(C)CN(CC)C(=O)CS(=O)(=O)c1ccc(F)c(F)c1.,C=C(C)CN(CC)C(=O)CS(=O)(=O)c1ccc(F)c(F)c1,benzene_ring
+155185,Modify the molecule CC(C)C(=O)Nc1cccc(C(=O)Nc2ccccc2C#N)c1 by removing a benzene_ring.,CC(C)C(=O)Nc1cccc(C(=O)Nc2ccccc2C#N)c1,benzene_ring
+101186,Modify the molecule N#Cc1ccc(-c2noc(-c3cccc(NC(=O)C4CC4)c3)n2)nc1 by removing a nitrile.,N#Cc1ccc(-c2noc(-c3cccc(NC(=O)C4CC4)c3)n2)nc1,nitrile
+116057,Modify the molecule C[C@@H]([NH2+]CCN1C(=O)CCC1=O)c1cccc(-c2ccccc2)c1 by removing a benzene_ring.,C[C@@H]([NH2+]CCN1C(=O)CCC1=O)c1cccc(-c2ccccc2)c1,benzene_ring
+205974,Please remove a amine from the molecule c1cc2c(cc1NC1=[N+]3CCCC[C@@H]3CS1)OCO2.,c1cc2c(cc1NC1=[N+]3CCCC[C@@H]3CS1)OCO2,amine
+8229,Please remove a benzene_ring from the molecule Cc1nnc(S[C@@H](C)C(=O)N(C)c2ccccc2)s1.,Cc1nnc(S[C@@H](C)C(=O)N(C)c2ccccc2)s1,benzene_ring
+86280,Please remove a halo from the molecule CC(=O)Nc1cc(NC(=O)N[C@@H]2CC=CCC2)ccc1Cl.,CC(=O)Nc1cc(NC(=O)N[C@@H]2CC=CCC2)ccc1Cl,halo
+56170,Remove a amide from the molecule O=C(/C=C/c1ccc(Br)o1)NCCC1=CCCCC1.,O=C(/C=C/c1ccc(Br)o1)NCCC1=CCCCC1,amide
+221493,Please remove a amide from the molecule COCc1ccc(C(=O)N[C@@H]2C[C@H]3C[C@@H]2[C@H]2CCC[C@@H]23)cc1.,COCc1ccc(C(=O)N[C@@H]2C[C@H]3C[C@@H]2[C@H]2CCC[C@@H]23)cc1,amide
+30916,Remove a halo from the molecule C[C@H](NC(=O)c1nc(Cl)ccc1Cl)c1ccc(Cl)s1.,C[C@H](NC(=O)c1nc(Cl)ccc1Cl)c1ccc(Cl)s1,halo
+245936,Please remove a benzene_ring from the molecule Cc1ccc(CC(=O)N2CC[C@@H]3[C@@H](CCC[NH+]3Cc3ccccc3)C2)cc1O.,Cc1ccc(CC(=O)N2CC[C@@H]3[C@@H](CCC[NH+]3Cc3ccccc3)C2)cc1O,benzene_ring
+197966,Remove a amide from the molecule CCCCN(C(=O)[C@H](C)[NH+]1CCC[C@H](O)C1)[C@@H]1CCS(=O)(=O)C1.,CCCCN(C(=O)[C@H](C)[NH+]1CCC[C@H](O)C1)[C@@H]1CCS(=O)(=O)C1,amide
+1848,Modify the molecule COc1ccc([C@@H]2c3nc[nH]c3CCN2C(=O)c2cc(C3CC3)nc3ccccc23)cc1 by removing a benzene_ring.,COc1ccc([C@@H]2c3nc[nH]c3CCN2C(=O)c2cc(C3CC3)nc3ccccc23)cc1,benzene_ring
+16370,Please remove a benzene_ring from the molecule CCCS(=O)(=O)CC(=O)Nc1c(C)cccc1C(C)C.,CCCS(=O)(=O)CC(=O)Nc1c(C)cccc1C(C)C,benzene_ring
+207588,Remove a benzene_ring from the molecule C[C@@H]1CN(c2ccc(CCl)cc2F)C[C@H]1C.,C[C@@H]1CN(c2ccc(CCl)cc2F)C[C@H]1C,benzene_ring
+141555,Please remove a amine from the molecule Nc1cc(N)nc(SCc2cc(-c3cccs3)on2)n1.,Nc1cc(N)nc(SCc2cc(-c3cccs3)on2)n1,amine
+104518,Please remove a hydroxyl from the molecule CC[NH+](Cc1ccc(Oc2ncccn2)cc1)[C@H]1CS(=O)(=O)C[C@@H]1O.,CC[NH+](Cc1ccc(Oc2ncccn2)cc1)[C@H]1CS(=O)(=O)C[C@@H]1O,hydroxyl
+126475,Remove a amide from the molecule CCC(=O)Nc1nonc1-c1nc2ccccc2n1Cc1cc(OC)ccc1C.,CCC(=O)Nc1nonc1-c1nc2ccccc2n1Cc1cc(OC)ccc1C,amide
+182561,Remove a amide from the molecule CC[NH+]1CCC[C@H](NC(=O)[C@@H]2CCC[NH2+][C@@H]2C)C1.,CC[NH+]1CCC[C@H](NC(=O)[C@@H]2CCC[NH2+][C@@H]2C)C1,amide
+195974,Modify the molecule COc1ccccc1NC(=O)c1c([O-])c2sccc2n(Cc2ccccc2)c1=O by removing a benzene_ring.,COc1ccccc1NC(=O)c1c([O-])c2sccc2n(Cc2ccccc2)c1=O,benzene_ring
+6766,Modify the molecule [NH3+]CCOCC(=O)Nc1ccc2c(c1)OCCO2 by removing a amide.,[NH3+]CCOCC(=O)Nc1ccc2c(c1)OCCO2,amide
+73039,Please remove a amide from the molecule N#Cc1csc(C(=O)N2C[C@H]3CC=CC[C@@H]3C2)c1.,N#Cc1csc(C(=O)N2C[C@H]3CC=CC[C@@H]3C2)c1,amide
+16747,Modify the molecule O=C(CCl)N1N=C(c2cccs2)C[C@@H]1c1ccccc1 by removing a halo.,O=C(CCl)N1N=C(c2cccs2)C[C@@H]1c1ccccc1,halo
+47134,Modify the molecule O=C(NCc1ccnc(Oc2ccc(F)cc2)c1)N[C@@H]1CCCC[C@@H]1CO by removing a halo.,O=C(NCc1ccnc(Oc2ccc(F)cc2)c1)N[C@@H]1CCCC[C@@H]1CO,halo
+184568,Please remove a benzene_ring from the molecule COc1ccc(/N=C2/CC(=O)C(=O)c3ccccc32)cc1.,COc1ccc(/N=C2/CC(=O)C(=O)c3ccccc32)cc1,benzene_ring
+130104,Please remove a amine from the molecule CCc1nnc2sc(-c3ccc(CNC(=S)NC(=O)c4ccc(F)cc4)cc3)nn12.,CCc1nnc2sc(-c3ccc(CNC(=S)NC(=O)c4ccc(F)cc4)cc3)nn12,amine
+238818,Modify the molecule CCC(CC)[C@H](O)[C@H]1CCO[C@]2(CCOC2)C1 by removing a hydroxyl.,CCC(CC)[C@H](O)[C@H]1CCO[C@]2(CCOC2)C1,hydroxyl
+144915,Remove a amide from the molecule O=C(N[C@@H](C(=O)NCCN1CCOCC1)C12CC3CC(CC(C3)C1)C2)c1ccc(Cl)cc1.,O=C(N[C@@H](C(=O)NCCN1CCOCC1)C12CC3CC(CC(C3)C1)C2)c1ccc(Cl)cc1,amide
+154888,Please remove a amine from the molecule O=C(NNc1nc(-c2ccncc2)no1)Nc1cnc(C2CC2)nc1.,O=C(NNc1nc(-c2ccncc2)no1)Nc1cnc(C2CC2)nc1,amine
+102234,Remove a hydroxyl from the molecule O=C(COc1ccc(Br)cc1)N1CCC[C@@H](O)C1.,O=C(COc1ccc(Br)cc1)N1CCC[C@@H](O)C1,hydroxyl
+200028,Remove a benzene_ring from the molecule COc1cccc(/C=N/NC(=O)C(=O)Nc2ccccc2Cl)c1OC.,COc1cccc(/C=N/NC(=O)C(=O)Nc2ccccc2Cl)c1OC,benzene_ring
+64683,Remove a amide from the molecule O=C(Nc1cccc(CNC(=O)[C@@H]2COc3ccccc3O2)c1)C1CC1.,O=C(Nc1cccc(CNC(=O)[C@@H]2COc3ccccc3O2)c1)C1CC1,amide
+75899,Please remove a amide from the molecule CCO[C@@H]1C[C@@H]([O-])C12CCN(C(=O)c1cnc3c(C)cccn3c1=O)CC2.,CCO[C@@H]1C[C@@H]([O-])C12CCN(C(=O)c1cnc3c(C)cccn3c1=O)CC2,amide
+152411,Remove a nitrile from the molecule CN[C@]1(C#N)CCC[C@@H]1CC[NH+]1CC[C@@H]2CCCC[C@@H]2C1.,CN[C@]1(C#N)CCC[C@@H]1CC[NH+]1CC[C@@H]2CCCC[C@@H]2C1,nitrile
+132417,Remove a halo from the molecule C[C@H]([NH2+][C@@H]1c2cccc(F)c2CC[C@@H]1C)c1nccs1.,C[C@H]([NH2+][C@@H]1c2cccc(F)c2CC[C@@H]1C)c1nccs1,halo
+194995,Please remove a halo from the molecule C[C@@H](C(N)=O)[NH+]1CCN(C(=O)c2ccc(C(F)(F)F)cc2)CC1.,C[C@@H](C(N)=O)[NH+]1CCN(C(=O)c2ccc(C(F)(F)F)cc2)CC1,halo
+70787,Please remove a hydroxyl from the molecule COc1ccc(Cl)cc1[C@H](O)[C@H]1CSCCS1.,COc1ccc(Cl)cc1[C@H](O)[C@H]1CSCCS1,hydroxyl
+120334,Remove a amide from the molecule CCn1c(SCC(=O)N[C@@H]2CCCC[C@H]2C)nc2ncccc2c1=O.,CCn1c(SCC(=O)N[C@@H]2CCCC[C@H]2C)nc2ncccc2c1=O,amide
+196649,Please remove a benzene_ring from the molecule NC(=O)c1ccc(N2CCO[C@@H](c3ccc(F)c(Cl)c3)C2)nn1.,NC(=O)c1ccc(N2CCO[C@@H](c3ccc(F)c(Cl)c3)C2)nn1,benzene_ring
+118964,Modify the molecule CCOC(=O)Nc1ccc(NS(=O)(=O)c2cc(C)ccc2F)cc1 by removing a amine.,CCOC(=O)Nc1ccc(NS(=O)(=O)c2cc(C)ccc2F)cc1,amine
+38820,Remove a amide from the molecule CNC(=O)c1ccc(N[C@H]2CCCC[C@H]2C)c([N+](=O)[O-])c1.,CNC(=O)c1ccc(N[C@H]2CCCC[C@H]2C)c([N+](=O)[O-])c1,amide
+70715,Remove a benzene_ring from the molecule CN(CCN1CCOCC1)C(=O)CCc1ncc(-c2ccccc2)o1.,CN(CCN1CCOCC1)C(=O)CCc1ncc(-c2ccccc2)o1,benzene_ring
+172041,Modify the molecule CC1(C)C[C@@](C#N)(NC2CCCC2)C(C)(C)O1 by removing a nitrile.,CC1(C)C[C@@](C#N)(NC2CCCC2)C(C)(C)O1,nitrile
+88381,Modify the molecule COC(=O)C1(NC(=O)c2cc3cc(C)ccc3o2)CCSCC1 by removing a amide.,COC(=O)C1(NC(=O)c2cc3cc(C)ccc3o2)CCSCC1,amide
+10606,Please remove a benzene_ring from the molecule Cc1cc(C)c(C[NH+]2CCC[C@H](N3CCCC3=O)C2)cc1C.,Cc1cc(C)c(C[NH+]2CCC[C@H](N3CCCC3=O)C2)cc1C,benzene_ring
+212892,Modify the molecule O=C(N[C@@H](c1cccnc1)C(F)(F)F)c1cnn(-c2nccc(-c3ccco3)n2)c1C1CC1 by removing a amide.,O=C(N[C@@H](c1cccnc1)C(F)(F)F)c1cnn(-c2nccc(-c3ccco3)n2)c1C1CC1,amide
+205220,Please remove a amide from the molecule CC1=C(C(=O)Nc2ccccc2C)C2(CCCCC2)[C@H](C(N)=O)C(=O)N1.,CC1=C(C(=O)Nc2ccccc2C)C2(CCCCC2)[C@H](C(N)=O)C(=O)N1,amide
+32498,Please remove a hydroxyl from the molecule CCCCCC[C@@H](O)[C@H]1CCc2cccnc21.,CCCCCC[C@@H](O)[C@H]1CCc2cccnc21,hydroxyl
+143677,Modify the molecule CN[C@]1(C#N)CCC[C@H]1CCOc1ccccc1 by removing a amine.,CN[C@]1(C#N)CCC[C@H]1CCOc1ccccc1,amine
+224917,Modify the molecule Nc1nc(N2CC[C@@H](OCCCc3ccccc3)C2)ncc1[N+](=O)[O-] by removing a nitro.,Nc1nc(N2CC[C@@H](OCCCc3ccccc3)C2)ncc1[N+](=O)[O-],nitro
+239462,Modify the molecule COc1ccc([C@H](NC(=O)c2cccc(OC)n2)c2nccn2C)cc1 by removing a benzene_ring.,COc1ccc([C@H](NC(=O)c2cccc(OC)n2)c2nccn2C)cc1,benzene_ring
+46292,Modify the molecule O=C(Nc1ccc(OCCc2ccccc2)nc1)C(=O)N[C@@H]1CC=CCC1 by removing a amide.,O=C(Nc1ccc(OCCc2ccccc2)nc1)C(=O)N[C@@H]1CC=CCC1,amide
+77301,Remove a amide from the molecule Cc1ccc2[nH+]c(N3CCC(C(=O)NCCC[NH+]4CCN(c5ccc(F)cc5)CC4)CC3)[nH]c2c1.,Cc1ccc2[nH+]c(N3CCC(C(=O)NCCC[NH+]4CCN(c5ccc(F)cc5)CC4)CC3)[nH]c2c1,amide
+154188,Please remove a halo from the molecule CC(C)C(=O)NCCC[NH2+][C@@H]1CCc2c(F)cc(Br)cc21.,CC(C)C(=O)NCCC[NH2+][C@@H]1CCc2c(F)cc(Br)cc21,halo
+166148,Remove a amide from the molecule Cc1ccc(NC(=O)C[C@@H](NC(N)=O)c2ccccc2)cc1C(F)(F)F.,Cc1ccc(NC(=O)C[C@@H](NC(N)=O)c2ccccc2)cc1C(F)(F)F,amide
+232520,Please remove a amide from the molecule C[C@@H]1Cc2cc(C(=O)N3CCn4c(nnc4C4CC[NH+](C)CC4)C3)ccc2O1.,C[C@@H]1Cc2cc(C(=O)N3CCn4c(nnc4C4CC[NH+](C)CC4)C3)ccc2O1,amide
+194565,Please remove a amide from the molecule COc1ccc(CN(C)C(=O)CSCc2ccc(F)cc2)cc1.,COc1ccc(CN(C)C(=O)CSCc2ccc(F)cc2)cc1,amide
+243451,Modify the molecule O=C(/C=C/c1ccco1)N(CCN1CCOCC1)c1ccccc1 by removing a benzene_ring.,O=C(/C=C/c1ccco1)N(CCN1CCOCC1)c1ccccc1,benzene_ring
+83226,Modify the molecule CC[C@@H]1COCCN1C(=O)[C@@H]1CC(=O)N(c2cc(OC)c(OC)c(OC)c2)C1 by removing a benzene_ring.,CC[C@@H]1COCCN1C(=O)[C@@H]1CC(=O)N(c2cc(OC)c(OC)c(OC)c2)C1,benzene_ring
+233934,Please remove a amide from the molecule Cc1ccc(NC(=O)CSc2nc3ccccc3nc2N2CCOCC2)cc1.,Cc1ccc(NC(=O)CSc2nc3ccccc3nc2N2CCOCC2)cc1,amide
+174911,Modify the molecule C[C@H]1CCCC[C@H]1NC(=O)C[NH+]1CCc2nc(N3CCCC3)[nH]c(=O)c2C1 by removing a amide.,C[C@H]1CCCC[C@H]1NC(=O)C[NH+]1CCc2nc(N3CCCC3)[nH]c(=O)c2C1,amide
+801,Modify the molecule CC[C@@H](C)n1nccc1NC(=O)C(=O)N1CCc2cc(F)ccc2C1 by removing a amide.,CC[C@@H](C)n1nccc1NC(=O)C(=O)N1CCc2cc(F)ccc2C1,amide
+122701,Remove a amide from the molecule O=C(Cc1cccs1)N1CCc2nocc2C1.,O=C(Cc1cccs1)N1CCc2nocc2C1,amide
+204458,Remove a benzene_ring from the molecule COc1ccc(CC(=O)Nc2ccc3c(c2)CN(CCc2ccc(F)cc2)C(=O)[C@H](C)O3)cc1.,COc1ccc(CC(=O)Nc2ccc3c(c2)CN(CCc2ccc(F)cc2)C(=O)[C@H](C)O3)cc1,benzene_ring
+220493,Modify the molecule COc1ccc([C@@H]2CC(=O)Nc3c2c([O-])nc2nc4ccccc4n32)cc1OC by removing a benzene_ring.,COc1ccc([C@@H]2CC(=O)Nc3c2c([O-])nc2nc4ccccc4n32)cc1OC,benzene_ring
+23002,Remove a amide from the molecule CN(Cc1ccc(N(C)C)cc1)C(=O)c1cccc(-n2cnnn2)c1.,CN(Cc1ccc(N(C)C)cc1)C(=O)c1cccc(-n2cnnn2)c1,amide
+191351,Modify the molecule COc1ccc(CCNC(=O)c2sc(-c3c(F)cccc3OC)nc2C)cc1 by removing a benzene_ring.,COc1ccc(CCNC(=O)c2sc(-c3c(F)cccc3OC)nc2C)cc1,benzene_ring
+175391,Remove a benzene_ring from the molecule Cc1nnc(-c2cc(S(=O)(=O)N3CCN(c4cc(Cl)ccc4C)CC3)c[nH]2)o1.,Cc1nnc(-c2cc(S(=O)(=O)N3CCN(c4cc(Cl)ccc4C)CC3)c[nH]2)o1,benzene_ring
+170463,Please remove a amide from the molecule C[C@@]1(C(=O)N[C@H]2CCN(c3ccccc3)C2=O)Cc2ccccc2C(=O)O1.,C[C@@]1(C(=O)N[C@H]2CCN(c3ccccc3)C2=O)Cc2ccccc2C(=O)O1,amide
+70807,Please remove a benzene_ring from the molecule COc1ccc(/C=C/c2ccnc(NS(=O)(=O)c3ccc(N)cc3)n2)cc1.,COc1ccc(/C=C/c2ccnc(NS(=O)(=O)c3ccc(N)cc3)n2)cc1,benzene_ring
+66073,Please remove a amide from the molecule COCCN(Cc1ccoc1)C(=O)c1c(F)cccc1F.,COCCN(Cc1ccoc1)C(=O)c1c(F)cccc1F,amide
+224338,Modify the molecule Cc1cccc([C@H]2[C@@H](C(=O)[O-])CC(=O)N2C)c1 by removing a benzene_ring.,Cc1cccc([C@H]2[C@@H](C(=O)[O-])CC(=O)N2C)c1,benzene_ring
+106986,Remove a amine from the molecule C[C@H](NC(=O)CNc1cccc(NC(=O)c2ccco2)c1)c1ccccc1.,C[C@H](NC(=O)CNc1cccc(NC(=O)c2ccco2)c1)c1ccccc1,amine
+45788,Remove a amide from the molecule CC(=O)c1cccc(NC(=O)N2CCC(C(=O)N(C)C(C)C)CC2)c1.,CC(=O)c1cccc(NC(=O)N2CCC(C(=O)N(C)C(C)C)CC2)c1,amide
+38278,Modify the molecule CCOC(=O)c1cccc(NC[C@@](C)(O)c2cccs2)n1 by removing a amine.,CCOC(=O)c1cccc(NC[C@@](C)(O)c2cccs2)n1,amine
+45720,Please remove a benzene_ring from the molecule CSc1ccccc1[C@H](Cl)[C@@H](C)c1ccncc1.,CSc1ccccc1[C@H](Cl)[C@@H](C)c1ccncc1,benzene_ring
+136717,Modify the molecule CC(C)(C)OC(=O)N1CCC[C@@H]1C[S@@](=O)c1nc2cc([N+](=O)[O-])ccc2s1 by removing a nitro.,CC(C)(C)OC(=O)N1CCC[C@@H]1C[S@@](=O)c1nc2cc([N+](=O)[O-])ccc2s1,nitro
+128495,Please remove a amide from the molecule O=C(N[C@H]1CCCc2ccccc21)c1ccc2c(c1)[nH]c(=O)n2C1CCCC1.,O=C(N[C@H]1CCCc2ccccc21)c1ccc2c(c1)[nH]c(=O)n2C1CCCC1,amide
+143236,Modify the molecule CCc1nsc(NCCS(=O)(=O)CC)n1 by removing a amine.,CCc1nsc(NCCS(=O)(=O)CC)n1,amine
+85147,Modify the molecule Cn1c(S[C@H]2CCCCNC2=O)nc2sc3c(c2c1=O)CCC3 by removing a amide.,Cn1c(S[C@H]2CCCCNC2=O)nc2sc3c(c2c1=O)CCC3,amide
+246965,Modify the molecule CCc1c(C(=O)N2C[C@@H](c3ccccc3C)C[C@@H]2C)[nH]c(C)c1C(C)=O by removing a benzene_ring.,CCc1c(C(=O)N2C[C@@H](c3ccccc3C)C[C@@H]2C)[nH]c(C)c1C(C)=O,benzene_ring
+203006,Remove a nitro from the molecule CC(C)c1cc(C(=O)NNC(=O)c2cccc([N+](=O)[O-])c2)nn1C.,CC(C)c1cc(C(=O)NNC(=O)c2cccc([N+](=O)[O-])c2)nn1C,nitro
+227582,Please remove a amide from the molecule CCCn1cc(C(=O)NCc2cc(CC(C)C)on2)c(C)n1.,CCCn1cc(C(=O)NCc2cc(CC(C)C)on2)c(C)n1,amide
+57732,Please remove a benzene_ring from the molecule O=C(/C=C/c1ccccc1[N+](=O)[O-])OCC(=O)c1ccc2c(c1)OCO2.,O=C(/C=C/c1ccccc1[N+](=O)[O-])OCC(=O)c1ccc2c(c1)OCO2,benzene_ring
+76202,Please remove a benzene_ring from the molecule Cc1ccc(N2C(=O)N(Cc3ccccc3Cl)[C@H]3CS(=O)(=O)C[C@@H]32)cc1Cl.,Cc1ccc(N2C(=O)N(Cc3ccccc3Cl)[C@H]3CS(=O)(=O)C[C@@H]32)cc1Cl,benzene_ring
+68858,Please remove a halo from the molecule O=C(Nc1cnn(CC(F)F)c1)N1CCC[C@@H](C[NH+]2CCCCCC2)C1.,O=C(Nc1cnn(CC(F)F)c1)N1CCC[C@@H](C[NH+]2CCCCCC2)C1,halo
+12325,Please remove a halo from the molecule Cc1ccccc1OCCN(C)S(=O)(=O)c1ncn(C)c1Cl.,Cc1ccccc1OCCN(C)S(=O)(=O)c1ncn(C)c1Cl,halo
+220024,Modify the molecule COc1c(C)cc(CN2C[C@@H](C)OC[C@@H]2C)cc1C by removing a benzene_ring.,COc1c(C)cc(CN2C[C@@H](C)OC[C@@H]2C)cc1C,benzene_ring
+7538,Modify the molecule Cc1ccc(NC(=O)N2CCC[C@H](c3nnc(C(=O)Nc4ccc(F)cc4)s3)C2)c(C)c1 by removing a amide.,Cc1ccc(NC(=O)N2CCC[C@H](c3nnc(C(=O)Nc4ccc(F)cc4)s3)C2)c(C)c1,amide
+208329,Please remove a hydroxyl from the molecule COc1cc2c(cc1C[NH+]1[C@H]3CC[C@@H]1CC(O)(Cn1nc(C4CC4)ccc1=O)C3)CCC2.,COc1cc2c(cc1C[NH+]1[C@H]3CC[C@@H]1CC(O)(Cn1nc(C4CC4)ccc1=O)C3)CCC2,hydroxyl
+106199,Please remove a halo from the molecule Cc1onc(-c2ccccc2Cl)c1C(=O)NCCC1[NH+]=c2ccccc2=[NH+]1.,Cc1onc(-c2ccccc2Cl)c1C(=O)NCCC1[NH+]=c2ccccc2=[NH+]1,halo
+129766,Modify the molecule CN[C@]1(C#N)CC[C@@H](N2CCO[C@H](C)C2)C1 by removing a nitrile.,CN[C@]1(C#N)CC[C@@H](N2CCO[C@H](C)C2)C1,nitrile
+93944,Please remove a amine from the molecule CCN(CCNS(C)(=O)=O)c1cccc(C)c1.,CCN(CCNS(C)(=O)=O)c1cccc(C)c1,amine
+136921,Please remove a amide from the molecule COC(=O)[C@@H](NC(=O)[C@@H](C)Cc1ccccc1F)c1ccc(F)c(F)c1.,COC(=O)[C@@H](NC(=O)[C@@H](C)Cc1ccccc1F)c1ccc(F)c(F)c1,amide
+209290,Modify the molecule COCC[NH+](C1C[C@@H](C)C[C@H](C)C1)[C@@H](C)C(N)=O by removing a amide.,COCC[NH+](C1C[C@@H](C)C[C@H](C)C1)[C@@H](C)C(N)=O,amide
+80000,Modify the molecule CC(C)c1cc(C(F)(F)F)c2c([C@@H]3CCCN(C(=O)CN4CCCC4=O)C3)noc2n1 by removing a halo.,CC(C)c1cc(C(F)(F)F)c2c([C@@H]3CCCN(C(=O)CN4CCCC4=O)C3)noc2n1,halo
+239399,Modify the molecule Cc1ncc([C@@H](C)[NH2+][C@H](C)c2ccc3c(c2)CC(=O)N3)s1 by removing a amide.,Cc1ncc([C@@H](C)[NH2+][C@H](C)c2ccc3c(c2)CC(=O)N3)s1,amide
+60379,Please remove a amide from the molecule C[C@H](c1ccncc1)N(C)C(=O)[C@H]1C=C[C@@H]([NH3+])C1.,C[C@H](c1ccncc1)N(C)C(=O)[C@H]1C=C[C@@H]([NH3+])C1,amide
+206573,Please remove a benzene_ring from the molecule CCOC(=O)c1ccc2c(c1)[C@H]1C=CC[C@@H]1[C@@H](c1cc(OC)c(OC)c(OC)c1)N2.,CCOC(=O)c1ccc2c(c1)[C@H]1C=CC[C@@H]1[C@@H](c1cc(OC)c(OC)c(OC)c1)N2,benzene_ring
+146826,Modify the molecule Fc1cccc(F)c1N[C@@H]1CCCC[C@H]1[C@@H]1CCC[NH2+]1 by removing a halo.,Fc1cccc(F)c1N[C@@H]1CCCC[C@H]1[C@@H]1CCC[NH2+]1,halo
+6552,Modify the molecule C/C=C(/C)C(=O)Nc1cc(Cl)ccc1N1CC[NH+](C)CC1 by removing a halo.,C/C=C(/C)C(=O)Nc1cc(Cl)ccc1N1CC[NH+](C)CC1,halo
+84828,Please remove a halo from the molecule COc1cc(Br)cc(/C=N/c2ccc(F)cc2)c1O.,COc1cc(Br)cc(/C=N/c2ccc(F)cc2)c1O,halo
+86565,Modify the molecule Cc1cccc(N2CCN(c3nc4ccccc4c(=O)[nH]3)CC2)c1 by removing a benzene_ring.,Cc1cccc(N2CCN(c3nc4ccccc4c(=O)[nH]3)CC2)c1,benzene_ring
+202137,Remove a nitrile from the molecule CC(C)Cc1[nH]c(=O)c(C#N)c2c1COC(C)(C)C2.,CC(C)Cc1[nH]c(=O)c(C#N)c2c1COC(C)(C)C2,nitrile
+42728,Remove a nitrile from the molecule CC[C@@H]1CCC[C@](C#N)(Cc2nccs2)C1.,CC[C@@H]1CCC[C@](C#N)(Cc2nccs2)C1,nitrile
+220623,Modify the molecule CC(C)(C)OC(=O)/C=C(\N)c1ccccc1 by removing a benzene_ring.,CC(C)(C)OC(=O)/C=C(\N)c1ccccc1,benzene_ring
+248662,Please remove a amine from the molecule CCc1c(N)nnn1CC[NH+]1CCCCC1.,CCc1c(N)nnn1CC[NH+]1CCCCC1,amine
+12526,Remove a hydroxyl from the molecule C[N+]1(C[C@H](O)COC(=O)C23CC4CC(CC(C4)C2)C3)CCOCC1.,C[N+]1(C[C@H](O)COC(=O)C23CC4CC(CC(C4)C2)C3)CCOCC1,hydroxyl
+127284,Remove a amide from the molecule CCCCCC[C@]1(C)NC(=O)N(Cc2csc(C)n2)C1=O.,CCCCCC[C@]1(C)NC(=O)N(Cc2csc(C)n2)C1=O,amide
+180555,Please remove a benzene_ring from the molecule Cc1c(C(=O)NC(c2ccccc2)c2ccccc2)nnn1-c1ccccc1.,Cc1c(C(=O)NC(c2ccccc2)c2ccccc2)nnn1-c1ccccc1,benzene_ring
+67109,Please remove a amide from the molecule CC(C)Cc1nnc(NC(=O)[C@H]2C[C@H]2c2cc(Cl)cc(Cl)c2)s1.,CC(C)Cc1nnc(NC(=O)[C@H]2C[C@H]2c2cc(Cl)cc(Cl)c2)s1,amide
+51846,Please remove a benzene_ring from the molecule COCCCn1c(C(=O)Nc2ccc(C)cc2)cc2c(=O)n3ccccc3nc21.,COCCCn1c(C(=O)Nc2ccc(C)cc2)cc2c(=O)n3ccccc3nc21,benzene_ring
+17810,Please remove a benzene_ring from the molecule Cc1cccc(N2CC[NH+]([C@@H](CC(C)C)c3nnnn3C(C)(C)C)CC2)c1C.,Cc1cccc(N2CC[NH+]([C@@H](CC(C)C)c3nnnn3C(C)(C)C)CC2)c1C,benzene_ring
+194450,Modify the molecule O=C(CCOCc1ccccc1)NC[C@@H]1CN2CCCC[C@@H]2CO1 by removing a benzene_ring.,O=C(CCOCc1ccccc1)NC[C@@H]1CN2CCCC[C@@H]2CO1,benzene_ring
+152787,Remove a benzene_ring from the molecule O=[N+]([O-])c1ccc(S(=O)(=O)Nc2nc(-c3ccco3)c(-c3ccco3)s2)cc1.,O=[N+]([O-])c1ccc(S(=O)(=O)Nc2nc(-c3ccco3)c(-c3ccco3)s2)cc1,benzene_ring
+26972,Please remove a amide from the molecule COc1cccc(-c2cc(C(=O)N3CCN(C(=O)[C@@H]4C[C@@H]4c4ccccc4)CC3)[nH]n2)c1.,COc1cccc(-c2cc(C(=O)N3CCN(C(=O)[C@@H]4C[C@@H]4c4ccccc4)CC3)[nH]n2)c1,amide
+77974,Remove a amide from the molecule C=CCn1c(SCC(=O)NC(=O)NCC(C)C)nc2ccccc21.,C=CCn1c(SCC(=O)NC(=O)NCC(C)C)nc2ccccc21,amide
+194061,Modify the molecule Cc1ccc2c(c1)c1nnc(SCC(=O)N(C)C3CCCCC3)nc1n2C by removing a amide.,Cc1ccc2c(c1)c1nnc(SCC(=O)N(C)C3CCCCC3)nc1n2C,amide
+63900,Please remove a benzene_ring from the molecule Cc1ccc(C(=O)N2CCC[C@@H](c3nnc(C)s3)C2)cc1.,Cc1ccc(C(=O)N2CCC[C@@H](c3nnc(C)s3)C2)cc1,benzene_ring
+35817,Remove a amine from the molecule CC(C)[C@H](Sc1nnc(-c2cccs2)n1N)C(=O)NC1CCCCC1.,CC(C)[C@H](Sc1nnc(-c2cccs2)n1N)C(=O)NC1CCCCC1,amine
+104937,Remove a amine from the molecule Cc1ccc(CSc2cc(Cl)ccc2N)o1.,Cc1ccc(CSc2cc(Cl)ccc2N)o1,amine
+85492,Modify the molecule Cc1nn(-c2ccccc2)c2nc(-c3cccs3)n3c4ccccc4nc3c2c1=O by removing a benzene_ring.,Cc1nn(-c2ccccc2)c2nc(-c3cccs3)n3c4ccccc4nc3c2c1=O,benzene_ring
+234442,Please remove a amine from the molecule COC(=O)[C@@H](N)CSc1ccncc1.,COC(=O)[C@@H](N)CSc1ccncc1,amine
+1022,Please remove a amide from the molecule C[C@H]1CC(=O)N(CC(=O)Nc2cccc3ccccc23)c2ccccc2S1.,C[C@H]1CC(=O)N(CC(=O)Nc2cccc3ccccc23)c2ccccc2S1,amide
+40421,Please remove a hydroxyl from the molecule C[C@@H](O)CC(C)(C)CNC(=O)N1CCC[C@@H](O)C1.,C[C@@H](O)CC(C)(C)CNC(=O)N1CCC[C@@H](O)C1,hydroxyl
+208146,Remove a benzene_ring from the molecule CN(C(=O)Cn1c(CCNC(=O)c2cccnc2)nc2ccccc21)c1ccccc1.,CN(C(=O)Cn1c(CCNC(=O)c2cccnc2)nc2ccccc21)c1ccccc1,benzene_ring
+92757,Remove a halo from the molecule C=CCNC(=O)CCCn1nc([N+](=O)[O-])c(Br)c1C.,C=CCNC(=O)CCCn1nc([N+](=O)[O-])c(Br)c1C,halo
+169594,Please remove a benzene_ring from the molecule COc1ccc(CN(C)Cc2c(C)n(C)n(-c3ccccc3)c2=O)cc1C.,COc1ccc(CN(C)Cc2c(C)n(C)n(-c3ccccc3)c2=O)cc1C,benzene_ring
+138384,Modify the molecule CC(C)(O)C[C@]1(C(=O)[O-])CCc2ccccc2C1 by removing a hydroxyl.,CC(C)(O)C[C@]1(C(=O)[O-])CCc2ccccc2C1,hydroxyl
+202592,Modify the molecule CCCN[C@@H]1[C@H]([NH+](CC(C)C)C(C)C)CCC1(C)C by removing a amine.,CCCN[C@@H]1[C@H]([NH+](CC(C)C)C(C)C)CCC1(C)C,amine
+27197,Modify the molecule CC(=O)[C@@H]1CC[C@@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@@]4(C)[C@@H]3CC[C@]12C by removing a hydroxyl.,CC(=O)[C@@H]1CC[C@@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@@]4(C)[C@@H]3CC[C@]12C,hydroxyl
+200183,Remove a benzene_ring from the molecule COc1ccc(OCC[NH2+][C@H]2CCC[C@H](C)[C@@H]2C)cc1.,COc1ccc(OCC[NH2+][C@H]2CCC[C@H](C)[C@@H]2C)cc1,benzene_ring
+238169,Please remove a halo from the molecule CN(C[C@H](O)CN1CCOCC1)c1cc[nH+]cc1Cl.,CN(C[C@H](O)CN1CCOCC1)c1cc[nH+]cc1Cl,halo
+24880,Modify the molecule Cc1ccc(-c2csc3ncn(CC(=O)Nc4ccc(F)cc4F)c(=O)c23)s1 by removing a benzene_ring.,Cc1ccc(-c2csc3ncn(CC(=O)Nc4ccc(F)cc4F)c(=O)c23)s1,benzene_ring
+130283,Please remove a halo from the molecule C=C(C)C[NH2+]C[C@@]1(O)CCCN(Cc2ccc(F)c(F)c2)C1=O.,C=C(C)C[NH2+]C[C@@]1(O)CCCN(Cc2ccc(F)c(F)c2)C1=O,halo
+140001,Please remove a halo from the molecule O=C(Nc1ccccc1Cl)NC12CC3CC(CC(C3)C1)C2.,O=C(Nc1ccccc1Cl)NC12CC3CC(CC(C3)C1)C2,halo
+90657,Modify the molecule C[C@H](CCc1ccco1)NC(=O)c1ccc(Cl)c(S(C)(=O)=O)c1 by removing a amide.,C[C@H](CCc1ccco1)NC(=O)c1ccc(Cl)c(S(C)(=O)=O)c1,amide
+63681,Please remove a benzene_ring from the molecule Cc1nc(C)n(Cc2cccc(NC(=O)[C@H](NC(N)=O)C(C)C)c2)n1.,Cc1nc(C)n(Cc2cccc(NC(=O)[C@H](NC(N)=O)C(C)C)c2)n1,benzene_ring
+174358,Modify the molecule Cc1ccc(S(=O)(=O)N2CCOC[C@H]2c2c(C)n[nH]c2C)c(Br)c1 by removing a halo.,Cc1ccc(S(=O)(=O)N2CCOC[C@H]2c2c(C)n[nH]c2C)c(Br)c1,halo
+196093,Please remove a halo from the molecule CCOC(=O)[C@@H](C)NCc1cc(Cl)cs1.,CCOC(=O)[C@@H](C)NCc1cc(Cl)cs1,halo
+231018,Modify the molecule Cc1ccc(/C=N/C(C)C)cc1 by removing a benzene_ring.,Cc1ccc(/C=N/C(C)C)cc1,benzene_ring
+219635,Modify the molecule CCC[C@H](C(N)=[NH2+])N1CCN(C(=O)N(CC)CC)CC1 by removing a amine.,CCC[C@H](C(N)=[NH2+])N1CCN(C(=O)N(CC)CC)CC1,amine
+127514,Remove a amine from the molecule CCc1cnc(CCNc2ccccc2S(=O)(=O)C(F)F)s1.,CCc1cnc(CCNc2ccccc2S(=O)(=O)C(F)F)s1,amine
+90111,Please remove a benzene_ring from the molecule Cc1nc(COc2ccccc2C(=O)N[C@H]2CCOc3ccccc32)no1.,Cc1nc(COc2ccccc2C(=O)N[C@H]2CCOc3ccccc32)no1,benzene_ring
+196133,Modify the molecule CNC(=O)c1ccccc1NC(=O)c1ccc(Cl)cc1 by removing a benzene_ring.,CNC(=O)c1ccccc1NC(=O)c1ccc(Cl)cc1,benzene_ring
+159529,Modify the molecule CCCN1C(=O)C(C)(C)COc2cc(NC(=O)Cc3ccc(OC)cc3)ccc21 by removing a amide.,CCCN1C(=O)C(C)(C)COc2cc(NC(=O)Cc3ccc(OC)cc3)ccc21,amide
+32968,Remove a amide from the molecule CC(C)c1ocnc1CS[C@H](C)C(=O)NCc1ccc(F)cc1.,CC(C)c1ocnc1CS[C@H](C)C(=O)NCc1ccc(F)cc1,amide
+15638,Remove a amide from the molecule Cc1ccc(S(=O)(=O)N2CCN(C(=O)c3ccc(N(C)C)cc3)CC2)cc1.,Cc1ccc(S(=O)(=O)N2CCN(C(=O)c3ccc(N(C)C)cc3)CC2)cc1,amide
+184890,Please remove a benzene_ring from the molecule O=C(Nc1cccc(-c2nnc3n2CCC3)c1)N[C@@H]1C[C@H]2CCCc3cccc1c32.,O=C(Nc1cccc(-c2nnc3n2CCC3)c1)N[C@@H]1C[C@H]2CCCc3cccc1c32,benzene_ring
+121893,Please remove a amide from the molecule CC[C@@H]1C(=O)NCC[NH+]1Cc1nc(-c2ccccc2OC)oc1C.,CC[C@@H]1C(=O)NCC[NH+]1Cc1nc(-c2ccccc2OC)oc1C,amide
+127891,Remove a amide from the molecule Cc1nc(-c2ccccc2Br)cc([C@H]2C[NH+]3CC[C@@H]2C[C@@H]3CNC(=O)c2ccco2)n1.,Cc1nc(-c2ccccc2Br)cc([C@H]2C[NH+]3CC[C@@H]2C[C@@H]3CNC(=O)c2ccco2)n1,amide
+48183,Remove a nitrile from the molecule COc1ccc(-c2nc(COC(=O)c3cc(C#N)cn3C)no2)cc1.,COc1ccc(-c2nc(COC(=O)c3cc(C#N)cn3C)no2)cc1,nitrile
+169419,Please remove a amide from the molecule CC(=O)Nc1ccc(C)c(NC(=O)N[C@H]2C[C@H]2C)c1.,CC(=O)Nc1ccc(C)c(NC(=O)N[C@H]2C[C@H]2C)c1,amide
+184952,Please remove a amide from the molecule O=C(/C=C/c1nc2ccccc2o1)N1CCC[C@@H]1c1nnc2ccccn12.,O=C(/C=C/c1nc2ccccc2o1)N1CCC[C@@H]1c1nnc2ccccn12,amide
+126094,Remove a amide from the molecule O=C(c1csc2c1CCCC2)N1CCC[C@@H](N2CCN(c3ccccc3)CC2)C1.,O=C(c1csc2c1CCCC2)N1CCC[C@@H](N2CCN(c3ccccc3)CC2)C1,amide
+110357,Please remove a halo from the molecule CC1=C(C(=O)N(C)C)[C@@H](c2cc(F)ccc2F)NC(=S)N1.,CC1=C(C(=O)N(C)C)[C@@H](c2cc(F)ccc2F)NC(=S)N1,halo
+186575,Remove a halo from the molecule COC(=O)/C(C)=C/CSc1cc(F)ccc1N.,COC(=O)/C(C)=C/CSc1cc(F)ccc1N,halo
+27102,Please remove a benzene_ring from the molecule COc1ccc(CC(=O)NNC(=O)COc2ccc3ccccc3c2)cc1.,COc1ccc(CC(=O)NNC(=O)COc2ccc3ccccc3c2)cc1,benzene_ring
+120304,Please remove a benzene_ring from the molecule C=CCn1nc(SC[C@@H](O)CO)nc1-c1ccc(Br)cc1.,C=CCn1nc(SC[C@@H](O)CO)nc1-c1ccc(Br)cc1,benzene_ring
+19325,Please remove a benzene_ring from the molecule CCS(=O)(=O)c1ccc(CC(=O)Nc2nnc(-c3cccc(F)c3)o2)cc1.,CCS(=O)(=O)c1ccc(CC(=O)Nc2nnc(-c3cccc(F)c3)o2)cc1,benzene_ring
+210893,Modify the molecule C=CCOc1ccc(OC(=O)c2ncccc2C(F)(F)F)cc1 by removing a benzene_ring.,C=CCOc1ccc(OC(=O)c2ncccc2C(F)(F)F)cc1,benzene_ring
+218758,Modify the molecule Cl[C@@H](CNc1ccc2nnnn2n1)c1ccccc1 by removing a benzene_ring.,Cl[C@@H](CNc1ccc2nnnn2n1)c1ccccc1,benzene_ring
+54429,Modify the molecule Cc1onc(-c2ccccc2)c1C(=O)N(C)CC(=O)N(C)C by removing a benzene_ring.,Cc1onc(-c2ccccc2)c1C(=O)N(C)CC(=O)N(C)C,benzene_ring
+195696,Modify the molecule CC(=O)OC1=C(C(C)=O)N(C(C)=O)S(=O)(=O)c2ccccc21 by removing a amide.,CC(=O)OC1=C(C(C)=O)N(C(C)=O)S(=O)(=O)c2ccccc21,amide
+88352,Remove a nitro from the molecule Cc1noc(/C=C\c2ccc3c(c2)n(C)c(=O)n3C)c1[N+](=O)[O-].,Cc1noc(/C=C\c2ccc3c(c2)n(C)c(=O)n3C)c1[N+](=O)[O-],nitro
+213468,Remove a amide from the molecule CCS[C@H]1CCCCN(C(=O)[C@H](C)Sc2ccccn2)C1.,CCS[C@H]1CCCCN(C(=O)[C@H](C)Sc2ccccn2)C1,amide
+221465,Please remove a amide from the molecule CC(C)(C)c1noc(CSCCCN2C(=O)CNC2=O)n1.,CC(C)(C)c1noc(CSCCCN2C(=O)CNC2=O)n1,amide
+100645,Modify the molecule CN(Cc1ccccc1)S(=O)(=O)c1ccc(C(=O)Nc2nc3c(F)cc(F)cc3s2)cc1 by removing a amide.,CN(Cc1ccccc1)S(=O)(=O)c1ccc(C(=O)Nc2nc3c(F)cc(F)cc3s2)cc1,amide
+5965,Please remove a nitro from the molecule CC[C@H]1CCCC[C@H]1[NH2+]Cc1ccc([N+](=O)[O-])cc1.,CC[C@H]1CCCC[C@H]1[NH2+]Cc1ccc([N+](=O)[O-])cc1,nitro
+13120,Remove a benzene_ring from the molecule CC[NH2+][C@H]1[C@H]([S@@](=O)c2cccc(OC)c2)CCCC1(C)C.,CC[NH2+][C@H]1[C@H]([S@@](=O)c2cccc(OC)c2)CCCC1(C)C,benzene_ring
+142592,Modify the molecule COC(=O)[C@@H](Cc1c[nH]cn1)NC(=O)c1ccc(-c2ccccc2)cc1 by removing a amide.,COC(=O)[C@@H](Cc1c[nH]cn1)NC(=O)c1ccc(-c2ccccc2)cc1,amide
+198939,Modify the molecule COc1ccc(-c2onc3ccc(C(=O)/C=C/N(C)C)cc23)cc1 by removing a benzene_ring.,COc1ccc(-c2onc3ccc(C(=O)/C=C/N(C)C)cc23)cc1,benzene_ring
+191966,Modify the molecule COc1ccccc1CC1CCN(C(=O)c2c(C)nn(C)c2C)CC1 by removing a benzene_ring.,COc1ccccc1CC1CCN(C(=O)c2c(C)nn(C)c2C)CC1,benzene_ring
+32089,Modify the molecule CC(C)N(CCCO)c1nc(Cl)ncc1F by removing a hydroxyl.,CC(C)N(CCCO)c1nc(Cl)ncc1F,hydroxyl
+1763,Please remove a benzene_ring from the molecule CCCC(=O)Nc1cccc(CNC(=O)N2CCSCC2)c1.,CCCC(=O)Nc1cccc(CNC(=O)N2CCSCC2)c1,benzene_ring
+66523,Please remove a benzene_ring from the molecule CCC(=O)Nc1cc(NC(C)=O)ccc1C.,CCC(=O)Nc1cc(NC(C)=O)ccc1C,benzene_ring
+242130,Remove a amide from the molecule CC[C@H](Sc1nnc(-c2cccc(N)c2)n1C)C(=O)Nc1ccc(Br)cc1.,CC[C@H](Sc1nnc(-c2cccc(N)c2)n1C)C(=O)Nc1ccc(Br)cc1,amide
+80489,Modify the molecule COc1ccccc1C(=O)NNC(=O)CCCc1cc(F)ccc1F by removing a benzene_ring.,COc1ccccc1C(=O)NNC(=O)CCCc1cc(F)ccc1F,benzene_ring
+32736,Remove a amide from the molecule CCC(=O)NC(=S)N1CCN(C(c2ccccc2)c2ccccc2)CC1.,CCC(=O)NC(=S)N1CCN(C(c2ccccc2)c2ccccc2)CC1,amide
+8591,Remove a benzene_ring from the molecule O=S(=O)(Nc1ccccc1Cn1cncn1)c1ccc2ccccc2c1.,O=S(=O)(Nc1ccccc1Cn1cncn1)c1ccc2ccccc2c1,benzene_ring
+12773,Modify the molecule Cc1cccc(NC(=O)c2c(N)c(C(=O)c3ccc([N+](=O)[O-])cc3)n3ccccc23)c1 by removing a benzene_ring.,Cc1cccc(NC(=O)c2c(N)c(C(=O)c3ccc([N+](=O)[O-])cc3)n3ccccc23)c1,benzene_ring
+93639,Remove a amide from the molecule Cc1cc(=O)c(C(=O)Nc2cnc(C(C)(C)C)nc2)c[nH]1.,Cc1cc(=O)c(C(=O)Nc2cnc(C(C)(C)C)nc2)c[nH]1,amide
+193847,Remove a amine from the molecule CCOC(=O)c1cnc(N)nc1C(C)(C)C.,CCOC(=O)c1cnc(N)nc1C(C)(C)C,amine
+226015,Please remove a benzene_ring from the molecule C[C@](C(=O)[O-])(c1cc(F)cc(F)c1)[NH+]1CCCC1.,C[C@](C(=O)[O-])(c1cc(F)cc(F)c1)[NH+]1CCCC1,benzene_ring
+202885,Remove a amide from the molecule CC(C)(C)[C@@H](NC(=O)Cn1ccnc1)c1cccs1.,CC(C)(C)[C@@H](NC(=O)Cn1ccnc1)c1cccs1,amide
+136996,Remove a amide from the molecule C[S@@](=O)Cc1cccc(C(=O)NCC(=O)Nc2nccs2)c1.,C[S@@](=O)Cc1cccc(C(=O)NCC(=O)Nc2nccs2)c1,amide
+98027,Modify the molecule COc1ccccc1/C=C/C(=O)OCC(=O)c1ccc2c(c1)OCCO2 by removing a benzene_ring.,COc1ccccc1/C=C/C(=O)OCC(=O)c1ccc2c(c1)OCCO2,benzene_ring
+86084,Modify the molecule Nc1c(S(=O)(=O)c2cccs2)c2nc3ccccc3nc2n1/N=C/c1c[nH]c2ccccc12 by removing a amine.,Nc1c(S(=O)(=O)c2cccs2)c2nc3ccccc3nc2n1/N=C/c1c[nH]c2ccccc12,amine
+69777,Modify the molecule CCCNc1ncnc2c1cnn2CCNC(=O)c1cc(Br)ccc1Cl by removing a halo.,CCCNc1ncnc2c1cnn2CCNC(=O)c1cc(Br)ccc1Cl,halo
+93026,Modify the molecule Cc1noc(C)c1[C@H](C)NC(=O)C(=O)Nc1cnc2ccccc2c1 by removing a amide.,Cc1noc(C)c1[C@H](C)NC(=O)C(=O)Nc1cnc2ccccc2c1,amide
+56332,Remove a amide from the molecule O=C(c1ccc(-n2cncn2)cc1)N1CCCN(c2ccc(C(F)(F)F)cn2)CC1.,O=C(c1ccc(-n2cncn2)cc1)N1CCCN(c2ccc(C(F)(F)F)cn2)CC1,amide
+149513,Remove a amide from the molecule Cc1occc1C(=O)NCC(=O)N1CC[C@@H](C)[C@H](O)C1.,Cc1occc1C(=O)NCC(=O)N1CC[C@@H](C)[C@H](O)C1,amide
+67684,Please remove a benzene_ring from the molecule Oc1cccc([C@H]2c3[nH+]c[nH]c3CCN2Cc2ccnn2-c2ccccc2)c1.,Oc1cccc([C@H]2c3[nH+]c[nH]c3CCN2Cc2ccnn2-c2ccccc2)c1,benzene_ring
+126898,Remove a amide from the molecule C[C@H](Sc1ccccn1)C(=O)N[C@H](CO)c1cc(F)c(F)c(F)c1.,C[C@H](Sc1ccccn1)C(=O)N[C@H](CO)c1cc(F)c(F)c(F)c1,amide
+59462,Modify the molecule CC(C)(C)c1ccc(Cn2c(CN3CCOCC3)nc3ccccc3c2=O)cc1 by removing a benzene_ring.,CC(C)(C)c1ccc(Cn2c(CN3CCOCC3)nc3ccccc3c2=O)cc1,benzene_ring
+121461,Modify the molecule CC[NH+]1CCN(CCNC(=O)CC[C@H]2Cc3ccccc3NC2=O)CC1 by removing a amide.,CC[NH+]1CCN(CCNC(=O)CC[C@H]2Cc3ccccc3NC2=O)CC1,amide
+128773,Modify the molecule CC[C@]1(c2ccccc2)NC(=O)N(C[C@@H](O)c2ccccc2Cl)C1=O by removing a benzene_ring.,CC[C@]1(c2ccccc2)NC(=O)N(C[C@@H](O)c2ccccc2Cl)C1=O,benzene_ring
+125691,Remove a amine from the molecule CC(C)COCCNC(=O)NNc1ccccc1Cl.,CC(C)COCCNC(=O)NNc1ccccc1Cl,amine
+157069,Modify the molecule CC(C)CC(=O)Nc1ccc(NC(=O)N2CCO[C@H](c3cccc(F)c3)C2)cc1 by removing a amide.,CC(C)CC(=O)Nc1ccc(NC(=O)N2CCO[C@H](c3cccc(F)c3)C2)cc1,amide
+178314,Remove a benzene_ring from the molecule O=C([O-])c1ccccc1S[C@H]1CCOC2(CCCCC2)C1.,O=C([O-])c1ccccc1S[C@H]1CCOC2(CCCCC2)C1,benzene_ring
+199628,Please remove a hydroxyl from the molecule COc1ccc(NC(=O)N[C@H](CO)CC(C)C)cc1OC.,COc1ccc(NC(=O)N[C@H](CO)CC(C)C)cc1OC,hydroxyl
+137735,Remove a benzene_ring from the molecule COc1ccc(-c2cc(C(=O)N[C@@H]3CCc4ccccc43)n[nH]2)c(OC)c1.,COc1ccc(-c2cc(C(=O)N[C@@H]3CCc4ccccc43)n[nH]2)c(OC)c1,benzene_ring
+122208,Please remove a amide from the molecule CC(C)N1C(=O)C=C(c2ccc(Cl)cc2)Nc2cc([N+](=O)[O-])ccc21.,CC(C)N1C(=O)C=C(c2ccc(Cl)cc2)Nc2cc([N+](=O)[O-])ccc21,amide
+151603,Modify the molecule CN(CCc1cccs1)C(=O)c1cccc(CC#N)c1 by removing a nitrile.,CN(CCc1cccs1)C(=O)c1cccc(CC#N)c1,nitrile
+221740,Remove a amide from the molecule O=C(Nc1ccc(C[NH2+]Cc2cccc3cccnc23)cc1)c1ccco1.,O=C(Nc1ccc(C[NH2+]Cc2cccc3cccnc23)cc1)c1ccco1,amide
+27912,Remove a benzene_ring from the molecule Cc1cccc(N2CCN(C(=O)C[NH+](C)CCO)CC2)c1.,Cc1cccc(N2CCN(C(=O)C[NH+](C)CCO)CC2)c1,benzene_ring
+145464,Remove a halo from the molecule N#C/C(=C\c1cc2c(cc1Br)OCO2)c1nc2ccccc2[nH]1.,N#C/C(=C\c1cc2c(cc1Br)OCO2)c1nc2ccccc2[nH]1,halo
+197754,Modify the molecule O=C1CCC(=O)N1CCN1CC[NH+](Cc2ccoc2)CC1 by removing a amide.,O=C1CCC(=O)N1CCN1CC[NH+](Cc2ccoc2)CC1,amide
+181377,Modify the molecule CC(C)Cc1ccc([C@@H](C)C(=O)N[C@H](C(=O)[O-])C(C)C)cc1 by removing a amide.,CC(C)Cc1ccc([C@@H](C)C(=O)N[C@H](C(=O)[O-])C(C)C)cc1,amide
+121187,Modify the molecule COc1cccc(-c2noc(-c3ccc(OC(C)C)cc3)n2)c1 by removing a benzene_ring.,COc1cccc(-c2noc(-c3ccc(OC(C)C)cc3)n2)c1,benzene_ring
+178868,Remove a benzene_ring from the molecule CC(C)[C@H](C)CC(=O)Nc1ccccc1CN1C[C@@H](C)O[C@H](C)C1.,CC(C)[C@H](C)CC(=O)Nc1ccccc1CN1C[C@@H](C)O[C@H](C)C1,benzene_ring
+68583,Remove a halo from the molecule Cc1nc([C@@H]2CCN(C(=O)C3(c4ccc(Cl)cc4)CCOCC3)C2)ncc1C(N)=O.,Cc1nc([C@@H]2CCN(C(=O)C3(c4ccc(Cl)cc4)CCOCC3)C2)ncc1C(N)=O,halo
+52317,Modify the molecule Cc1ccc(F)c(CN2CCC(=O)NC[C@H]2C)c1Cl by removing a benzene_ring.,Cc1ccc(F)c(CN2CCC(=O)NC[C@H]2C)c1Cl,benzene_ring
+49331,Remove a amide from the molecule NC(=O)[C@@H]1CCCC[NH+]1CC(=O)NC(=O)NCC(F)(F)F.,NC(=O)[C@@H]1CCCC[NH+]1CC(=O)NC(=O)NCC(F)(F)F,amide
+74951,Remove a nitrile from the molecule CC(C)c1ccc(C#N)c(SCC(=O)c2c([O-])on[n+]2C)n1.,CC(C)c1ccc(C#N)c(SCC(=O)c2c([O-])on[n+]2C)n1,nitrile
+236839,Remove a amide from the molecule Cc1nc(N(C)C)ncc1C(=O)N[C@H]1Cc2ccccc2[C@@H]1[NH3+].,Cc1nc(N(C)C)ncc1C(=O)N[C@H]1Cc2ccccc2[C@@H]1[NH3+],amide
+145218,Please remove a halo from the molecule Cc1nn(C)c(C)c1[C@H](NC(=O)Nc1cccc2ccccc12)C(F)(F)F.,Cc1nn(C)c(C)c1[C@H](NC(=O)Nc1cccc2ccccc12)C(F)(F)F,halo
+206787,Modify the molecule N#Cc1cccc(S(=O)(=O)N[C@H](C#N)c2ccc(Cl)cc2)c1 by removing a amine.,N#Cc1cccc(S(=O)(=O)N[C@H](C#N)c2ccc(Cl)cc2)c1,amine
+122722,Modify the molecule CCOc1cc(/C=C/C(=O)c2scnc2C)cc(Cl)c1O by removing a benzene_ring.,CCOc1cc(/C=C/C(=O)c2scnc2C)cc(Cl)c1O,benzene_ring
+161657,Remove a benzene_ring from the molecule Cc1cc(=O)n2c(n1)SC[C@H]2CC(=O)Nc1cccc(Cl)c1.,Cc1cc(=O)n2c(n1)SC[C@H]2CC(=O)Nc1cccc(Cl)c1,benzene_ring
+96598,Remove a amide from the molecule CCNC(=O)[C@H]1CCCN(C(=O)N[C@@H](C)CSC)C1.,CCNC(=O)[C@H]1CCCN(C(=O)N[C@@H](C)CSC)C1,amide
+177794,Please remove a halo from the molecule Cc1cc(C)n(-c2cc(N3CCC[C@@H](C(=O)Nc4ccc(Br)c(C)c4)C3)ncn2)n1.,Cc1cc(C)n(-c2cc(N3CCC[C@@H](C(=O)Nc4ccc(Br)c(C)c4)C3)ncn2)n1,halo
+85808,Remove a amide from the molecule O=C(CCN1CCCC1=O)NCC1([NH+]2CCCCC2)CCOCC1.,O=C(CCN1CCCC1=O)NCC1([NH+]2CCCCC2)CCOCC1,amide
+83334,Please remove a amide from the molecule O=C(NCC(=O)N1CCN(Cc2ccccn2)CC1)NC1CCCCC1.,O=C(NCC(=O)N1CCN(Cc2ccccn2)CC1)NC1CCCCC1,amide
+50140,Please remove a amide from the molecule Cc1cccc(C(=O)N2CCCC2)c1NC(=O)NCc1ccccc1F.,Cc1cccc(C(=O)N2CCCC2)c1NC(=O)NCc1ccccc1F,amide
+143410,Modify the molecule COc1ccc(OC)c([C@@H]2CCCN2C(=O)c2ccoc2)c1 by removing a amide.,COc1ccc(OC)c([C@@H]2CCCN2C(=O)c2ccoc2)c1,amide
+182728,Modify the molecule C[C@@H](C(=O)Nc1ccccc1C(C)(C)C)N1CC[NH+](CCO)CC1 by removing a hydroxyl.,C[C@@H](C(=O)Nc1ccccc1C(C)(C)C)N1CC[NH+](CCO)CC1,hydroxyl
+211513,Remove a halo from the molecule COC[C@@H]1CCN(c2cc(C)c(F)cc2[C@H](C)[NH3+])C1.,COC[C@@H]1CCN(c2cc(C)c(F)cc2[C@H](C)[NH3+])C1,halo
+212510,Modify the molecule COc1ccc([C@H]2CCN(C(=O)NCc3cccc(OCC(F)F)n3)C2)cc1 by removing a halo.,COc1ccc([C@H]2CCN(C(=O)NCc3cccc(OCC(F)F)n3)C2)cc1,halo
+41465,Modify the molecule CC(C)C(=O)Nc1cccc(C(=O)Nc2ccccc2)c1 by removing a benzene_ring.,CC(C)C(=O)Nc1cccc(C(=O)Nc2ccccc2)c1,benzene_ring
+47190,Remove a amide from the molecule CC[C@H]1COCCN1C(=O)c1ccc2[nH]c(C)c(C)c2c1.,CC[C@H]1COCCN1C(=O)c1ccc2[nH]c(C)c(C)c2c1,amide
+26844,Modify the molecule O=C(Cn1nc2c(cc1=O)CCCC2)N1CC[C@]2(O)CCCC[C@@H]2C1 by removing a hydroxyl.,O=C(Cn1nc2c(cc1=O)CCCC2)N1CC[C@]2(O)CCCC[C@@H]2C1,hydroxyl
+32571,Remove a amide from the molecule Cc1cc(C)cc(NC(=S)NC(=O)c2cccc(F)c2)c1.,Cc1cc(C)cc(NC(=S)NC(=O)c2cccc(F)c2)c1,amide
+214318,Remove a benzene_ring from the molecule O=C(Nc1ccc(F)c(F)c1F)c1ccc([N+](=O)[O-])o1.,O=C(Nc1ccc(F)c(F)c1F)c1ccc([N+](=O)[O-])o1,benzene_ring
+163014,Remove a amine from the molecule CCOc1ccc(Nc2nc(CSc3nc4ccccc4o3)cc(=O)[nH]2)cc1.,CCOc1ccc(Nc2nc(CSc3nc4ccccc4o3)cc(=O)[nH]2)cc1,amine
+154572,Modify the molecule CC(C)[NH+](C)CCCCn1c([C@H](C)Cl)nc2cnccc21 by removing a halo.,CC(C)[NH+](C)CCCCn1c([C@H](C)Cl)nc2cnccc21,halo
+179508,Please remove a benzene_ring from the molecule COc1cc(C(=O)N(C)Cc2ccccc2OC(F)(F)F)cc(OC)c1C.,COc1cc(C(=O)N(C)Cc2ccccc2OC(F)(F)F)cc(OC)c1C,benzene_ring
+159885,Please remove a benzene_ring from the molecule NC(=O)[C@]1([NH3+])CCC[C@H]1CCSc1ccc(Br)cc1.,NC(=O)[C@]1([NH3+])CCC[C@H]1CCSc1ccc(Br)cc1,benzene_ring
+151171,Modify the molecule Cc1ccc(Cl)c(O[C@H](C)C(=O)NCCCc2ccccc2)c1 by removing a amide.,Cc1ccc(Cl)c(O[C@H](C)C(=O)NCCCc2ccccc2)c1,amide
+239650,Please remove a benzene_ring from the molecule COc1ccccc1CNC(=O)Nc1ccc(N2CC[NH+](C)CC2)cc1C.,COc1ccccc1CNC(=O)Nc1ccc(N2CC[NH+](C)CC2)cc1C,benzene_ring
+86230,Remove a halo from the molecule N#Cc1nc(/C=C/c2ccccc2Cl)oc1N1CCN(C(=O)c2cccc(Cl)c2)CC1.,N#Cc1nc(/C=C/c2ccccc2Cl)oc1N1CCN(C(=O)c2cccc(Cl)c2)CC1,halo
+103200,Please remove a benzene_ring from the molecule CCOc1ccc(OCC(=O)Oc2ccc3c4c(c(=O)oc3c2)CCC4)cc1.,CCOc1ccc(OCC(=O)Oc2ccc3c4c(c(=O)oc3c2)CCC4)cc1,benzene_ring
+191604,Modify the molecule CS(=O)(=O)Cc1cn2cc(Cl)cc(Cl)c2n1 by removing a halo.,CS(=O)(=O)Cc1cn2cc(Cl)cc(Cl)c2n1,halo
+6363,Please remove a halo from the molecule COc1ccc(C(=O)CCC(=O)N2C[C@@H](C)OC[C@@H]2C)cc1F.,COc1ccc(C(=O)CCC(=O)N2C[C@@H](C)OC[C@@H]2C)cc1F,halo
+8350,Remove a amide from the molecule Cc1oc2c(c1C(=O)NCCNC(=O)c1c(C)oc3c1CCCC3)CCCC2.,Cc1oc2c(c1C(=O)NCCNC(=O)c1c(C)oc3c1CCCC3)CCCC2,amide
+97802,Please remove a amide from the molecule O=C(C[NH+](Cc1ccco1)C1CCCC1)NCc1cccnc1.,O=C(C[NH+](Cc1ccco1)C1CCCC1)NCc1cccnc1,amide
+158213,Modify the molecule CC(C)NC(=O)c1ccc(NCc2ccc(F)c(Br)c2)cc1 by removing a halo.,CC(C)NC(=O)c1ccc(NCc2ccc(F)c(Br)c2)cc1,halo
+105398,Please remove a benzene_ring from the molecule Cc1ccc([C@@H](C)NC(=O)N[C@H](CCCO)c2ccccc2)cc1F.,Cc1ccc([C@@H](C)NC(=O)N[C@H](CCCO)c2ccccc2)cc1F,benzene_ring
+67835,Please remove a halo from the molecule O=[N+]([O-])/C=C/c1c(F)c(F)c(F)c(F)c1F.,O=[N+]([O-])/C=C/c1c(F)c(F)c(F)c(F)c1F,halo
+120941,Please remove a amide from the molecule CNC(=O)c1cccc(N2CCN(Cc3cccs3)CC2)n1.,CNC(=O)c1cccc(N2CCN(Cc3cccs3)CC2)n1,amide
+170570,Remove a benzene_ring from the molecule COc1ccc(CN2CCS(=O)(=O)[C@H](C)[C@H]2C)c(OC)c1.,COc1ccc(CN2CCS(=O)(=O)[C@H](C)[C@H]2C)c(OC)c1,benzene_ring
+72154,Remove a amide from the molecule C[C@H]1C[C@@H](C)CN(C(=O)C[NH+](C)CC2CC[NH2+]CC2)C1.,C[C@H]1C[C@@H](C)CN(C(=O)C[NH+](C)CC2CC[NH2+]CC2)C1,amide
+4895,Modify the molecule CC(C)CCC(=O)NNC(=O)NC[C@H](C)c1ccsc1 by removing a amide.,CC(C)CCC(=O)NNC(=O)NC[C@H](C)c1ccsc1,amide
+223555,Modify the molecule CC(=O)N[C@@]1(C(F)(F)F)NC(=O)N(C)C1=O by removing a halo.,CC(=O)N[C@@]1(C(F)(F)F)NC(=O)N(C)C1=O,halo
+237778,Please remove a amide from the molecule CC[C@@H](NC(=O)C1C[C@H](C)O[C@H](C)C1)c1ccc(Br)cc1.,CC[C@@H](NC(=O)C1C[C@H](C)O[C@H](C)C1)c1ccc(Br)cc1,amide
+183034,Remove a benzene_ring from the molecule COc1cc(OC)cc([C@H]2CCN(C(=O)c3c(F)cccc3Cl)C2)c1.,COc1cc(OC)cc([C@H]2CCN(C(=O)c3c(F)cccc3Cl)C2)c1,benzene_ring
+243646,Remove a benzene_ring from the molecule CC[C@H](NC(=O)N(C)[C@H](CC)CSC)c1ccc(F)cc1F.,CC[C@H](NC(=O)N(C)[C@H](CC)CSC)c1ccc(F)cc1F,benzene_ring
+239998,Please remove a amide from the molecule CCn1c(SCC(=O)Nc2c(C)cccc2C)nc2sc(C)c(C)c2c1=O.,CCn1c(SCC(=O)Nc2c(C)cccc2C)nc2sc(C)c(C)c2c1=O,amide
+83856,Remove a amide from the molecule CCc1cccc(C)c1NC(=O)c1cnc(SC)nc1-c1ccccc1.,CCc1cccc(C)c1NC(=O)c1cnc(SC)nc1-c1ccccc1,amide
+3664,Please remove a benzene_ring from the molecule O=[S@@](Cc1csc(-c2ccc(F)cc2)n1)c1cccc(F)c1.,O=[S@@](Cc1csc(-c2ccc(F)cc2)n1)c1cccc(F)c1,benzene_ring
+32914,Please remove a nitro from the molecule C[C@H]1OCC[C@@H]1C(=O)NCCOc1ccc([N+](=O)[O-])cc1.,C[C@H]1OCC[C@@H]1C(=O)NCCOc1ccc([N+](=O)[O-])cc1,nitro
+222205,Please remove a benzene_ring from the molecule Cc1ccccc1CC(=O)N1CCN([C@@H](C)c2nc(C3CC3)no2)CC1.,Cc1ccccc1CC(=O)N1CCN([C@@H](C)c2nc(C3CC3)no2)CC1,benzene_ring
+43312,Modify the molecule O=C(Cc1cn2ccsc2n1)N[C@H]1CCC[C@H]1Cc1ccccc1 by removing a amide.,O=C(Cc1cn2ccsc2n1)N[C@H]1CCC[C@H]1Cc1ccccc1,amide
+40686,Please remove a benzene_ring from the molecule CC[C@H](C#N)OC(=O)/C=C/c1c(F)cccc1F.,CC[C@H](C#N)OC(=O)/C=C/c1c(F)cccc1F,benzene_ring
+81567,Remove a amine from the molecule NC(=S)N/N=C1C(=N/N=C(\N)[S-])\Sc2ccccc2\1.,NC(=S)N/N=C1C(=N/N=C(\N)[S-])\Sc2ccccc2\1,amine
+208886,Please remove a halo from the molecule O=C(NC1(C(=O)[O-])CCCCC1)c1c[nH]c(=O)c(Cl)c1.,O=C(NC1(C(=O)[O-])CCCCC1)c1c[nH]c(=O)c(Cl)c1,halo
+77605,Please remove a hydroxyl from the molecule OC1CC23CCCCCCC2(C1)CC(O)C3.,OC1CC23CCCCCCC2(C1)CC(O)C3,hydroxyl
+244921,Modify the molecule CCCC(=O)N(C)Cc1c(CC)oc2ccccc12 by removing a amide.,CCCC(=O)N(C)Cc1c(CC)oc2ccccc12,amide
+43812,Remove a amide from the molecule Cc1cccc(CN2CCN(C(=O)c3cc(C#N)cn3C)CC2)c1.,Cc1cccc(CN2CCN(C(=O)c3cc(C#N)cn3C)CC2)c1,amide
+62948,Modify the molecule COc1cccc(-c2nc(Cn3cnc(C4CCC4)cc3=O)cs2)c1 by removing a benzene_ring.,COc1cccc(-c2nc(Cn3cnc(C4CCC4)cc3=O)cs2)c1,benzene_ring
+74799,Modify the molecule CCCCN(C)S(=O)(=O)N1CCO[C@H](c2cccc(F)c2)C1 by removing a benzene_ring.,CCCCN(C)S(=O)(=O)N1CCO[C@H](c2cccc(F)c2)C1,benzene_ring
+157059,Modify the molecule C[C@H]1CCC[C@@]2(CC[NH2+]C[C@@H]2c2ccccc2F)C1 by removing a halo.,C[C@H]1CCC[C@@]2(CC[NH2+]C[C@@H]2c2ccccc2F)C1,halo
+18945,Please remove a benzene_ring from the molecule Cc1ccc(C(N)=O)cc1NC(=O)N(Cc1cccc(F)c1)C[C@H]1CCCO1.,Cc1ccc(C(N)=O)cc1NC(=O)N(Cc1cccc(F)c1)C[C@H]1CCCO1,benzene_ring
+141615,Please remove a amide from the molecule CSc1nc(-c2ccco2)nc(C)c1C(=O)NCC[C@@H](O)C(C)C.,CSc1nc(-c2ccco2)nc(C)c1C(=O)NCC[C@@H](O)C(C)C,amide
+83667,Please remove a benzene_ring from the molecule C[C@@H](C1CC1)N(Cc1ccccc1)C(=O)c1ccc2c(c1)C(=O)N(C)C2=O.,C[C@@H](C1CC1)N(Cc1ccccc1)C(=O)c1ccc2c(c1)C(=O)N(C)C2=O,benzene_ring
+47958,Please remove a benzene_ring from the molecule CCc1nn(C)cc1CNC(=O)Nc1cc(C)ccc1-n1cc(C)cn1.,CCc1nn(C)cc1CNC(=O)Nc1cc(C)ccc1-n1cc(C)cn1,benzene_ring
+208872,Remove a amide from the molecule CC(=O)c1ccc(-c2cc(F)cc3c2O[C@H](CNC(=O)[C@@H]2CCOC(C)(C)C2)C3)s1.,CC(=O)c1ccc(-c2cc(F)cc3c2O[C@H](CNC(=O)[C@@H]2CCOC(C)(C)C2)C3)s1,amide
+195234,Please remove a amine from the molecule COc1ccccc1NS(=O)(=O)c1cc(NC(=O)c2ccco2)ccc1N1CCOCC1.,COc1ccccc1NS(=O)(=O)c1cc(NC(=O)c2ccco2)ccc1N1CCOCC1,amine
+42563,Modify the molecule Cc1ccc(NC(=O)C2([NH+](C)C)CCC2)cc1S(C)(=O)=O by removing a benzene_ring.,Cc1ccc(NC(=O)C2([NH+](C)C)CCC2)cc1S(C)(=O)=O,benzene_ring
+37423,Remove a halo from the molecule O=S(=O)(NCc1ccccc1)c1ccccc1Br.,O=S(=O)(NCc1ccccc1)c1ccccc1Br,halo
+212465,Modify the molecule C[C@@H](C1CC1)N(C(=O)CSc1nc2c(cc1C#N)CCCC2)C1CC1 by removing a amide.,C[C@@H](C1CC1)N(C(=O)CSc1nc2c(cc1C#N)CCCC2)C1CC1,amide
+92005,Remove a amide from the molecule CCOc1cccc2sc(NC(=O)[C@H]3CCCN(S(=O)(=O)c4ccc(C)cc4)C3)nc12.,CCOc1cccc2sc(NC(=O)[C@H]3CCCN(S(=O)(=O)c4ccc(C)cc4)C3)nc12,amide
+68526,Please remove a halo from the molecule COc1cccc2cc(C(=O)N3CCN(C(=O)[C@@H]4C[C@H]4c4ccc(F)cc4)CC3)oc12.,COc1cccc2cc(C(=O)N3CCN(C(=O)[C@@H]4C[C@H]4c4ccc(F)cc4)CC3)oc12,halo
+166176,Please remove a halo from the molecule COc1ccc(Br)cc1C[NH2+]C1CCC(O)CC1.,COc1ccc(Br)cc1C[NH2+]C1CCC(O)CC1,halo
+240940,Remove a benzene_ring from the molecule Cc1ccc(-c2nc(N3C[C@H](C)O[C@H](C)C3)ncc2-c2cncnc2)cc1.,Cc1ccc(-c2nc(N3C[C@H](C)O[C@H](C)C3)ncc2-c2cncnc2)cc1,benzene_ring
+100052,Please remove a amide from the molecule NC(=O)NC[C@H]1CCCCN1C(=O)CCCC1CCCC1.,NC(=O)NC[C@H]1CCCCN1C(=O)CCCC1CCCC1,amide
+94335,Please remove a halo from the molecule O=C(Cn1nc2c(c1NC(=O)c1cc3ccccc3o1)CSC2)NCc1ccc(F)cc1.,O=C(Cn1nc2c(c1NC(=O)c1cc3ccccc3o1)CSC2)NCc1ccc(F)cc1,halo
+249267,Modify the molecule CCc1nnc(SCCOc2ccc(F)cc2Cl)n1N by removing a amine.,CCc1nnc(SCCOc2ccc(F)cc2Cl)n1N,amine
+162401,Please remove a amide from the molecule COC(=O)c1ccc(F)c(NC(=O)[C@@H]2CCO[C@H]2C)c1.,COC(=O)c1ccc(F)c(NC(=O)[C@@H]2CCO[C@H]2C)c1,amide
+4563,Modify the molecule OCCC#Cc1cc(F)cc(C[NH+]2CCC[C@H]2CO)c1 by removing a halo.,OCCC#Cc1cc(F)cc(C[NH+]2CCC[C@H]2CO)c1,halo
+94266,Remove a halo from the molecule COc1cc(OC)c(N/C([O-])=C2/Oc3ccccc3NC2=O)cc1Cl.,COc1cc(OC)c(N/C([O-])=C2/Oc3ccccc3NC2=O)cc1Cl,halo
+219633,Please remove a benzene_ring from the molecule Cc1ccc2c(c1)N(C(=O)N1CCC(C(=O)Nc3ccccc3Cl)CC1)CCO2.,Cc1ccc2c(c1)N(C(=O)N1CCC(C(=O)Nc3ccccc3Cl)CC1)CCO2,benzene_ring
+189934,Modify the molecule Cc1c(Cl)cccc1NS(=O)(=O)c1ccc2c(c1)NC(=O)[C@H](C)C(=O)N2 by removing a benzene_ring.,Cc1c(Cl)cccc1NS(=O)(=O)c1ccc2c(c1)NC(=O)[C@H](C)C(=O)N2,benzene_ring
+226551,Remove a amide from the molecule COc1cccc(NC(=O)CSc2nccn(-c3ccc(C)c(C)c3)c2=O)c1.,COc1cccc(NC(=O)CSc2nccn(-c3ccc(C)c(C)c3)c2=O)c1,amide
+181257,Remove a benzene_ring from the molecule COc1cccc([C@H]2CC(=O)NC3=C2C(=O)C[C@H](c2cc(OC)c(OC)c(OC)c2)C3)c1.,COc1cccc([C@H]2CC(=O)NC3=C2C(=O)C[C@H](c2cc(OC)c(OC)c(OC)c2)C3)c1,benzene_ring
+129622,Modify the molecule O=C(c1csc(-c2ccnc(N3CCCC3)c2)n1)N1CCN(c2ccccc2F)CC1 by removing a halo.,O=C(c1csc(-c2ccnc(N3CCCC3)c2)n1)N1CCN(c2ccccc2F)CC1,halo
+46565,Modify the molecule Cc1noc(C)c1CN1CCN(C(=O)c2ccc(N(C)C)nc2)CC1 by removing a amide.,Cc1noc(C)c1CN1CCN(C(=O)c2ccc(N(C)C)nc2)CC1,amide
+67854,Remove a benzene_ring from the molecule C[C@H]([NH2+]CCO)c1cc(F)cc(F)c1.,C[C@H]([NH2+]CCO)c1cc(F)cc(F)c1,benzene_ring
+67216,Modify the molecule CCn1nc(CC(C)C)cc1C(=O)N1C[C@H]2CC=C(C)C[C@H]2C1 by removing a amide.,CCn1nc(CC(C)C)cc1C(=O)N1C[C@H]2CC=C(C)C[C@H]2C1,amide
+155846,Please remove a benzene_ring from the molecule COc1ccc2c(CC(=O)N(C)[C@H](C)c3ccc(F)cc3)coc2c1.,COc1ccc2c(CC(=O)N(C)[C@H](C)c3ccc(F)cc3)coc2c1,benzene_ring
+34452,Please remove a halo from the molecule CCOC(=N)Cc1ccc(Cl)c(Cl)c1.,CCOC(=N)Cc1ccc(Cl)c(Cl)c1,halo
+55774,Please remove a amine from the molecule Cc1ccc(S(=O)(=O)N[C@@H](C)C(=O)N2CCC2)cc1.,Cc1ccc(S(=O)(=O)N[C@@H](C)C(=O)N2CCC2)cc1,amine
+238822,Remove a amide from the molecule CC(=O)Nc1nc2ccc(NC(=O)NCCC(C)C)cc2s1.,CC(=O)Nc1nc2ccc(NC(=O)NCCC(C)C)cc2s1,amide
+179992,Modify the molecule CC(C)C[C@@H](C(=O)OCc1cccnc1)N1CCCCC1=O by removing a amide.,CC(C)C[C@@H](C(=O)OCc1cccnc1)N1CCCCC1=O,amide
+169405,Modify the molecule CCOC(=O)[C@@]1(N)CC[C@H]([NH+]2C[C@@H](C)[C@@H](C)C2)C1 by removing a amine.,CCOC(=O)[C@@]1(N)CC[C@H]([NH+]2C[C@@H](C)[C@@H](C)C2)C1,amine
+126937,Please remove a benzene_ring from the molecule COC(=O)[C@H]1CCN(C(=O)Cc2cccc(OCc3cccnc3)c2)C1.,COC(=O)[C@H]1CCN(C(=O)Cc2cccc(OCc3cccnc3)c2)C1,benzene_ring
+158399,Please remove a amine from the molecule Cc1cccc(NC2CC[NH+]([C@H](C)C(=O)Nc3cc(C)on3)CC2)[nH+]1.,Cc1cccc(NC2CC[NH+]([C@H](C)C(=O)Nc3cc(C)on3)CC2)[nH+]1,amine
+195187,Modify the molecule O=C(Nc1nnn[n-]1)c1cc2ccccc2s1 by removing a amide.,O=C(Nc1nnn[n-]1)c1cc2ccccc2s1,amide
+92023,Please remove a halo from the molecule O=C(CCn1ccc2cc(Br)ccc21)/N=C1\N=N[C@H]([C@H]2CCCO2)S1.,O=C(CCn1ccc2cc(Br)ccc21)/N=C1\N=N[C@H]([C@H]2CCCO2)S1,halo
+74534,Remove a benzene_ring from the molecule C[C@H](Cc1ccccc1F)C(=O)N[C@H]1CC[C@H]([NH+](C)C)C1.,C[C@H](Cc1ccccc1F)C(=O)N[C@H]1CC[C@H]([NH+](C)C)C1,benzene_ring
+224495,Please remove a benzene_ring from the molecule O=C(CN1CCN(c2ncccn2)CC1)Nc1ccc(Br)cc1.,O=C(CN1CCN(c2ncccn2)CC1)Nc1ccc(Br)cc1,benzene_ring
+224522,Please remove a amide from the molecule CCOC(=O)c1ccc(CNC(=O)c2cc(-c3csc(C)n3)c[nH]2)o1.,CCOC(=O)c1ccc(CNC(=O)c2cc(-c3csc(C)n3)c[nH]2)o1,amide
+122303,Remove a benzene_ring from the molecule N/C(=N/OCCCOc1ccccc1)c1ccc(F)c(F)c1.,N/C(=N/OCCCOc1ccccc1)c1ccc(F)c(F)c1,benzene_ring
+216404,Remove a benzene_ring from the molecule Fc1ccccc1[C@@H]1C[C@H](c2ccc(Cl)cc2)Nc2nnnn21.,Fc1ccccc1[C@@H]1C[C@H](c2ccc(Cl)cc2)Nc2nnnn21,benzene_ring
+45888,Modify the molecule COCCOc1ccc(NC(=O)C(=O)N[C@@H]2CCC[C@H](C)[C@H]2C)cc1 by removing a benzene_ring.,COCCOc1ccc(NC(=O)C(=O)N[C@@H]2CCC[C@H](C)[C@H]2C)cc1,benzene_ring
+4692,Modify the molecule O=C(Cc1ccc(N2CCCC2=O)cc1)Nn1cnc2ccccc2c1=O by removing a benzene_ring.,O=C(Cc1ccc(N2CCCC2=O)cc1)Nn1cnc2ccccc2c1=O,benzene_ring
+121485,Modify the molecule Cc1nc2ccccc2n1CCCNC(=O)c1ccc(-n2cccc2)nc1 by removing a amide.,Cc1nc2ccccc2n1CCCNC(=O)c1ccc(-n2cccc2)nc1,amide
+208837,Please remove a amine from the molecule CCOC(=O)/C=C1\NCCCN1Cc1ccccc1Cl.,CCOC(=O)/C=C1\NCCCN1Cc1ccccc1Cl,amine
+95056,Please remove a benzene_ring from the molecule Cc1nc(C[NH+]2CCN(Cc3cccc(F)c3)CC2)co1.,Cc1nc(C[NH+]2CCN(Cc3cccc(F)c3)CC2)co1,benzene_ring
+12608,Modify the molecule CC[S@](=O)[C@H]1CCCC[C@@H]1NC(=O)CNC(=O)Cc1ccccc1 by removing a benzene_ring.,CC[S@](=O)[C@H]1CCCC[C@@H]1NC(=O)CNC(=O)Cc1ccccc1,benzene_ring
+118482,Remove a amide from the molecule CCc1c(C)nn(CCNC(=O)c2cn[nH]n2)c1C.,CCc1c(C)nn(CCNC(=O)c2cn[nH]n2)c1C,amide
+65368,Modify the molecule Cc1cc(N(C)C)cc(C)c1NC(=O)c1ccnc(OC(C)(C)C)c1 by removing a amide.,Cc1cc(N(C)C)cc(C)c1NC(=O)c1ccnc(OC(C)(C)C)c1,amide
+122401,Please remove a benzene_ring from the molecule C[C@@H](Oc1ccc(N(C)S(C)(=O)=O)cc1)C(=O)NC1CC[NH+](C)CC1.,C[C@@H](Oc1ccc(N(C)S(C)(=O)=O)cc1)C(=O)NC1CC[NH+](C)CC1,benzene_ring
+147603,Please remove a nitro from the molecule Cn1ncc2nc3cc([N+](=O)[O-])ccc3c([O-])c21.,Cn1ncc2nc3cc([N+](=O)[O-])ccc3c([O-])c21,nitro
+91759,Remove a benzene_ring from the molecule CC(C)[C@H](CO)[NH+](Cc1ccccc1)C1CCSCC1.,CC(C)[C@H](CO)[NH+](Cc1ccccc1)C1CCSCC1,benzene_ring
+96766,Modify the molecule CCn1c(C)cc(C(=O)Nc2ccc(N3C(=O)CCCC3=O)cc2)c1C by removing a benzene_ring.,CCn1c(C)cc(C(=O)Nc2ccc(N3C(=O)CCCC3=O)cc2)c1C,benzene_ring
+136572,Modify the molecule COCCNC(=O)c1ccc(N2CCN(c3ncccc3C#N)CC2)nc1 by removing a nitrile.,COCCNC(=O)c1ccc(N2CCN(c3ncccc3C#N)CC2)nc1,nitrile
+129990,Remove a halo from the molecule CC(C)/C(=C\c1cc(Cl)c2c(c1)OCO2)CO.,CC(C)/C(=C\c1cc(Cl)c2c(c1)OCO2)CO,halo
+128453,Modify the molecule CCn1cc([C@H]2c3[nH]c4ccc(OC)cc4c3CCN2C(=O)c2ccc(Cl)cc2)cn1 by removing a benzene_ring.,CCn1cc([C@H]2c3[nH]c4ccc(OC)cc4c3CCN2C(=O)c2ccc(Cl)cc2)cn1,benzene_ring
+172234,Please remove a amine from the molecule Clc1ccccc1CNCCc1cn2ccccc2n1.,Clc1ccccc1CNCCc1cn2ccccc2n1,amine
+149979,Modify the molecule COc1c(F)c(F)cc2c(=O)c(C(=O)NC(C)(C)CO)cn(C3CC3)c12 by removing a hydroxyl.,COc1c(F)c(F)cc2c(=O)c(C(=O)NC(C)(C)CO)cn(C3CC3)c12,hydroxyl
+221164,Modify the molecule CCN1CCN(C(=O)c2ccc(OC)nc2)C[C@H](Cc2ccccc2-c2ccncc2)C1=O by removing a amide.,CCN1CCN(C(=O)c2ccc(OC)nc2)C[C@H](Cc2ccccc2-c2ccncc2)C1=O,amide
+73559,Modify the molecule CC[C@](C)([C@H](NC)c1ccc(C)s1)[NH+]1CCCC1 by removing a amine.,CC[C@](C)([C@H](NC)c1ccc(C)s1)[NH+]1CCCC1,amine
+77452,Modify the molecule Cc1ccc(SCCC(=O)NC2CC[NH+](CC(N)=O)CC2)cc1 by removing a amide.,Cc1ccc(SCCC(=O)NC2CC[NH+](CC(N)=O)CC2)cc1,amide
+37491,Please remove a amide from the molecule Cc1ccc(C(=O)N2CCCC2)c(C2CCN(C(=O)c3ccoc3)CC2)n1.,Cc1ccc(C(=O)N2CCCC2)c(C2CCN(C(=O)c3ccoc3)CC2)n1,amide
+143530,Remove a benzene_ring from the molecule Cc1ccc(-c2nc(NCC[C@@H]3CCC[NH+]3C)ncc2-c2cncnc2)cc1.,Cc1ccc(-c2nc(NCC[C@@H]3CCC[NH+]3C)ncc2-c2cncnc2)cc1,benzene_ring
+239402,Please remove a amine from the molecule COc1ccc(C2=NN3C(=NC(C)=C(C(N)=O)[C@H]3c3ccc4c(c3)OCO4)N2)cc1.,COc1ccc(C2=NN3C(=NC(C)=C(C(N)=O)[C@H]3c3ccc4c(c3)OCO4)N2)cc1,amine
+208380,Please remove a amide from the molecule O=C(NCC1CCN(c2nc3ccccc3o2)CC1)c1ccc2ccccc2c1.,O=C(NCC1CCN(c2nc3ccccc3o2)CC1)c1ccc2ccccc2c1,amide
+148165,Remove a amine from the molecule Nc1c(Nc2cc(Cl)cc(Cl)c2)ncnc1NC1CCCCC1.,Nc1c(Nc2cc(Cl)cc(Cl)c2)ncnc1NC1CCCCC1,amine
+24320,Remove a amine from the molecule Clc1ccc(NCc2ccncn2)cc1Br.,Clc1ccc(NCc2ccncn2)cc1Br,amine
+38436,Modify the molecule COc1cccc(O[C@@H](C)CNc2ncccc2C#N)c1 by removing a nitrile.,COc1cccc(O[C@@H](C)CNc2ncccc2C#N)c1,nitrile
+74,Remove a benzene_ring from the molecule COc1cccc(CN2CCc3nnc(CCc4ccccc4)n3CC2)c1.,COc1cccc(CN2CCc3nnc(CCc4ccccc4)n3CC2)c1,benzene_ring
+175409,Modify the molecule CCN(Cc1ccc(I)cc1)C(F)(F)F by removing a halo.,CCN(Cc1ccc(I)cc1)C(F)(F)F,halo
+50483,Please remove a halo from the molecule CC(=O)c1cc(F)ccc1OCC(=O)N[C@H]1CCOc2ccccc21.,CC(=O)c1cc(F)ccc1OCC(=O)N[C@H]1CCOc2ccccc21,halo
+8617,Remove a amine from the molecule Nc1nc(CC(=O)N2CCC[C@@H](c3[nH]ncc3-c3ccccc3)C2)cc(=O)[nH]1.,Nc1nc(CC(=O)N2CCC[C@@H](c3[nH]ncc3-c3ccccc3)C2)cc(=O)[nH]1,amine
+220002,Modify the molecule COC(=O)c1cccc(C(=O)NCCc2cnn(-c3ccccc3)c2)n1 by removing a benzene_ring.,COC(=O)c1cccc(C(=O)NCCc2cnn(-c3ccccc3)c2)n1,benzene_ring
+156324,Please remove a amide from the molecule O=C(Cc1ccc(F)cc1F)NCc1cc(Cl)c2c(c1)OCCO2.,O=C(Cc1ccc(F)cc1F)NCc1cc(Cl)c2c(c1)OCCO2,amide
+103224,Modify the molecule CCC(=O)[C@H]1CCCN(C(=O)C[C@@]2(c3ccccc3F)CC(=O)N(C3CCCC3)C2=O)C1 by removing a amide.,CCC(=O)[C@H]1CCCN(C(=O)C[C@@]2(c3ccccc3F)CC(=O)N(C3CCCC3)C2=O)C1,amide
+22233,Please remove a benzene_ring from the molecule Cc1cc(C(=O)Nc2c(Cl)cc(Cl)cc2C(=O)[O-])c(C)s1.,Cc1cc(C(=O)Nc2c(Cl)cc(Cl)cc2C(=O)[O-])c(C)s1,benzene_ring
+36414,Remove a halo from the molecule O=C(Nc1ccn(Cc2ccccn2)n1)c1c[nH]c2cccc(F)c12.,O=C(Nc1ccn(Cc2ccccn2)n1)c1c[nH]c2cccc(F)c12,halo
+134254,Please remove a amine from the molecule CCOC(=O)[C@H](CC(C)C)Nc1ncnc2onc(C)c12.,CCOC(=O)[C@H](CC(C)C)Nc1ncnc2onc(C)c12,amine
+108500,Remove a benzene_ring from the molecule Cc1occc1-c1nnc(SCc2cccc(OCC(F)(F)F)c2)n1C.,Cc1occc1-c1nnc(SCc2cccc(OCC(F)(F)F)c2)n1C,benzene_ring
+45559,Remove a halo from the molecule C/C(=C\c1ccc(F)cc1)C(=O)O[C@@H](C)c1ccccn1.,C/C(=C\c1ccc(F)cc1)C(=O)O[C@@H](C)c1ccccn1,halo
+217017,Modify the molecule Cc1nnc(CN(C(=O)c2nc(C3CC3)n3ccccc23)C(C)(C)C)o1 by removing a amide.,Cc1nnc(CN(C(=O)c2nc(C3CC3)n3ccccc23)C(C)(C)C)o1,amide
+45691,Modify the molecule COc1ccccc1[C@H](C)CC(=O)Nc1ccc(N2CCO[C@@H](C)C2)cc1 by removing a benzene_ring.,COc1ccccc1[C@H](C)CC(=O)Nc1ccc(N2CCO[C@@H](C)C2)cc1,benzene_ring
+142978,Remove a amide from the molecule CC(C)n1cc[nH+]c1C1CCN(C(=O)c2ccc3[nH]nnc3c2)CC1.,CC(C)n1cc[nH+]c1C1CCN(C(=O)c2ccc3[nH]nnc3c2)CC1,amide
+72341,Please remove a amide from the molecule CO[C@H]1C[C@@H](C(=O)[O-])N(C(=O)c2cc(SC)ccc2C)C1.,CO[C@H]1C[C@@H](C(=O)[O-])N(C(=O)c2cc(SC)ccc2C)C1,amide
+236180,Please remove a benzene_ring from the molecule O=C(NCC1CCN(c2cc[nH+]cc2)CC1)Nc1c(F)cc(F)cc1F.,O=C(NCC1CCN(c2cc[nH+]cc2)CC1)Nc1c(F)cc(F)cc1F,benzene_ring
+230871,Please remove a halo from the molecule C[C@@H]1Cc2cc(S(=O)(=O)Nc3ccc(Br)cc3)ccc2N1.,C[C@@H]1Cc2cc(S(=O)(=O)Nc3ccc(Br)cc3)ccc2N1,halo
+77183,Modify the molecule C[C@H](NC(=O)N[C@@](C)(CO)C1CCCCC1)c1ccc(C#N)cc1 by removing a nitrile.,C[C@H](NC(=O)N[C@@](C)(CO)C1CCCCC1)c1ccc(C#N)cc1,nitrile
+63725,Please remove a amide from the molecule Cc1c(Cl)cccc1NC(=O)C(=O)N/N=C/c1coc2ccc(Cl)cc2c1=O.,Cc1c(Cl)cccc1NC(=O)C(=O)N/N=C/c1coc2ccc(Cl)cc2c1=O,amide
+136221,Modify the molecule C[C@H](O)[C@@H]1CCC[NH+](CC(=O)Nc2ccccc2-c2ccccc2)C1 by removing a benzene_ring.,C[C@H](O)[C@@H]1CCC[NH+](CC(=O)Nc2ccccc2-c2ccccc2)C1,benzene_ring
+37184,Please remove a amide from the molecule NC(=O)c1ccc(NC(=O)Cc2csc(NC(=O)c3ccsc3)n2)cc1.,NC(=O)c1ccc(NC(=O)Cc2csc(NC(=O)c3ccsc3)n2)cc1,amide
+20753,Modify the molecule O=C(Cc1ccccc1O)N1CCN(S(=O)(=O)c2cc(Cl)ccc2Cl)CC1 by removing a amide.,O=C(Cc1ccccc1O)N1CCN(S(=O)(=O)c2cc(Cl)ccc2Cl)CC1,amide
+213485,Remove a amide from the molecule Cc1noc(C(C)C)c1C(=O)N1CCC[C@H]([NH+]2CCCC2)C1.,Cc1noc(C(C)C)c1C(=O)N1CCC[C@H]([NH+]2CCCC2)C1,amide
+198929,Remove a benzene_ring from the molecule Cn1ccnc1[C@@H](NC(=O)[C@H]1CCCN(C(=O)Nc2ccccc2)C1)c1ccc(F)cc1.,Cn1ccnc1[C@@H](NC(=O)[C@H]1CCCN(C(=O)Nc2ccccc2)C1)c1ccc(F)cc1,benzene_ring
+9923,Modify the molecule C[NH+](C)Cc1cccc(C[NH2+]Cc2ccn(-c3ccccc3)n2)c1 by removing a benzene_ring.,C[NH+](C)Cc1cccc(C[NH2+]Cc2ccn(-c3ccccc3)n2)c1,benzene_ring
+225313,Please remove a hydroxyl from the molecule O=C(NCCC1=CCCCC1)NC[C@@H]1CCC[C@H](O)C1.,O=C(NCCC1=CCCCC1)NC[C@@H]1CCC[C@H](O)C1,hydroxyl
+188221,Modify the molecule Cc1ccc(O[C@@H](C)C(=O)NCC2(N3CCOCC3)CCCCC2)cc1 by removing a amide.,Cc1ccc(O[C@@H](C)C(=O)NCC2(N3CCOCC3)CCCCC2)cc1,amide
+186611,Please remove a amide from the molecule CC1(C)CNC(=O)c2nc([C@@H](O)C[NH+]3CCCCCC3)[nH]c2C1.,CC1(C)CNC(=O)c2nc([C@@H](O)C[NH+]3CCCCCC3)[nH]c2C1,amide
+136295,Modify the molecule CC(C)Oc1ccc(CCNC(=O)N[C@@H](C)CO)cc1 by removing a hydroxyl.,CC(C)Oc1ccc(CCNC(=O)N[C@@H](C)CO)cc1,hydroxyl
+247908,Please remove a amide from the molecule C=CC[NH2+]CC(=O)N1CCn2cc[nH+]c2C1.,C=CC[NH2+]CC(=O)N1CCn2cc[nH+]c2C1,amide
+51524,Remove a benzene_ring from the molecule CCc1ccc(C(=O)[O-])cc1S(=O)(=O)C(CC)CC.,CCc1ccc(C(=O)[O-])cc1S(=O)(=O)C(CC)CC,benzene_ring
+96621,Please remove a nitrile from the molecule CC(C)[C@H]1CN(c2cc(C#N)c3ccccc3n2)CCS1.,CC(C)[C@H]1CN(c2cc(C#N)c3ccccc3n2)CCS1,nitrile
+97851,Modify the molecule COc1ccc(Cl)cc1NC(=O)CC[S@](=O)Cc1ccc(C)cc1 by removing a amide.,COc1ccc(Cl)cc1NC(=O)CC[S@](=O)Cc1ccc(C)cc1,amide
+67638,Remove a amide from the molecule C[NH2+]C[C@H](C)C(=O)N[C@H]1C=C[C@@H](C(=O)[O-])C1.,C[NH2+]C[C@H](C)C(=O)N[C@H]1C=C[C@@H](C(=O)[O-])C1,amide
+161196,Please remove a halo from the molecule CC(C)CC[C@@H](C)NC(=O)C(=O)Nc1cccc(F)c1.,CC(C)CC[C@@H](C)NC(=O)C(=O)Nc1cccc(F)c1,halo
+155153,Remove a benzene_ring from the molecule CN(CCc1cnccn1)C(=O)Nc1ccc(F)cc1.,CN(CCc1cnccn1)C(=O)Nc1ccc(F)cc1,benzene_ring
+22145,Remove a amide from the molecule COc1cccc2c(=O)c(C(=O)Nc3ccc(NC(C)=O)cc3)cn(C)c12.,COc1cccc2c(=O)c(C(=O)Nc3ccc(NC(C)=O)cc3)cn(C)c12,amide
+113946,Remove a amide from the molecule O=C(c1ccncc1Cl)N1CCCC[C@@H]1[C@@H]1CCC[NH2+]1.,O=C(c1ccncc1Cl)N1CCCC[C@@H]1[C@@H]1CCC[NH2+]1,amide
+18336,Modify the molecule CCn1cnc2sc(C(=O)Nc3ccc(C)c(Cl)c3)c(C)c2c1=O by removing a halo.,CCn1cnc2sc(C(=O)Nc3ccc(C)c(Cl)c3)c(C)c2c1=O,halo
+209960,Modify the molecule C[C@H](NC(=O)CO/N=C/C(=O)Nc1ccc(F)cc1)c1ccco1 by removing a amide.,C[C@H](NC(=O)CO/N=C/C(=O)Nc1ccc(F)cc1)c1ccco1,amide
+54104,Please remove a amide from the molecule CCOC(=O)c1c(NC(=O)CSc2nc(C)ccc2C#N)sc2c1CCC2.,CCOC(=O)c1c(NC(=O)CSc2nc(C)ccc2C#N)sc2c1CCC2,amide
+241335,Modify the molecule COc1cccc(C(=O)Nc2ccn(-c3ccc(C(C)C)cc3)n2)c1 by removing a amide.,COc1cccc(C(=O)Nc2ccn(-c3ccc(C(C)C)cc3)n2)c1,amide
+240311,Remove a benzene_ring from the molecule Cc1cccc(C2=CCN(C(=O)NCC[C@@H](C)[S@@](C)=O)CC2)c1.,Cc1cccc(C2=CCN(C(=O)NCC[C@@H](C)[S@@](C)=O)CC2)c1,benzene_ring
+213848,Remove a hydroxyl from the molecule CCC[C@H](C[NH3+])C1(O)CCC(c2ccccc2)CC1.,CCC[C@H](C[NH3+])C1(O)CCC(c2ccccc2)CC1,hydroxyl
+155319,Please remove a amide from the molecule COc1ccc(C)cc1NC(=O)C(=O)NCc1cc[nH+]c(N(C)C)c1.,COc1ccc(C)cc1NC(=O)C(=O)NCc1cc[nH+]c(N(C)C)c1,amide
+212620,Remove a benzene_ring from the molecule COc1ccc(/C=N/NC(=O)c2cc(C)nn2C)c(C(=O)[O-])c1OC.,COc1ccc(/C=N/NC(=O)c2cc(C)nn2C)c(C(=O)[O-])c1OC,benzene_ring
+214119,Please remove a hydroxyl from the molecule O=[N+]([O-])c1cc(Br)c(O)c(Cc2ccccc2)c1.,O=[N+]([O-])c1cc(Br)c(O)c(Cc2ccccc2)c1,hydroxyl
+85421,Modify the molecule N#CCc1ccc(S(=O)(=O)N[C@@H]2C[C@@H]2c2ccccc2F)cc1 by removing a halo.,N#CCc1ccc(S(=O)(=O)N[C@@H]2C[C@@H]2c2ccccc2F)cc1,halo
+196119,Remove a amide from the molecule Cc1nn(CC(=O)N2CCC[C@@H](C)C2)c(=O)c2ccccc12.,Cc1nn(CC(=O)N2CCC[C@@H](C)C2)c(=O)c2ccccc12,amide
+215202,Remove a halo from the molecule CCn1cc[nH+]c1C[C@H](O)c1cc(Cl)c2c(c1)OCO2.,CCn1cc[nH+]c1C[C@H](O)c1cc(Cl)c2c(c1)OCO2,halo
+37257,Please remove a benzene_ring from the molecule Cc1ccc(C(=O)N(CC(=O)N2CCn3cccc3[C@@H]2c2ccc(Cl)cc2)C(C)(C)C)cc1.,Cc1ccc(C(=O)N(CC(=O)N2CCn3cccc3[C@@H]2c2ccc(Cl)cc2)C(C)(C)C)cc1,benzene_ring
+174796,Modify the molecule O=C(CC1(n2cccc2)CCCCC1)NCCO by removing a hydroxyl.,O=C(CC1(n2cccc2)CCCCC1)NCCO,hydroxyl
+64577,Remove a amide from the molecule Cc1cc(C(=O)N2CCCC[C@@H]2CCn2cc[nH+]c2)c(C)o1.,Cc1cc(C(=O)N2CCCC[C@@H]2CCn2cc[nH+]c2)c(C)o1,amide
+48000,Please remove a amide from the molecule COC(=O)c1sc(NC(=O)c2c[nH]c(=O)cc2C)nc1C1CC1.,COC(=O)c1sc(NC(=O)c2c[nH]c(=O)cc2C)nc1C1CC1,amide
+203332,Remove a amide from the molecule O=C([C@H]1CCCC[NH+]1Cc1cccc([N+](=O)[O-])c1)N1CCOCC1.,O=C([C@H]1CCCC[NH+]1Cc1cccc([N+](=O)[O-])c1)N1CCOCC1,amide
+74206,Please remove a benzene_ring from the molecule O=C(Nc1ccc2c(c1)nc1n2CCN(c2ccccc2)C1)c1cccc(Br)c1.,O=C(Nc1ccc2c(c1)nc1n2CCN(c2ccccc2)C1)c1cccc(Br)c1,benzene_ring
+226239,Modify the molecule Cc1cccc(OC[C@@H](C)NC(=O)CNC(=O)c2ccoc2C)c1 by removing a benzene_ring.,Cc1cccc(OC[C@@H](C)NC(=O)CNC(=O)c2ccoc2C)c1,benzene_ring
+188704,Modify the molecule C[C@H](OC(=O)c1ccc(-n2cnnn2)cc1)C(=O)Nc1nc(-c2ccccc2)cs1 by removing a benzene_ring.,C[C@H](OC(=O)c1ccc(-n2cnnn2)cc1)C(=O)Nc1nc(-c2ccccc2)cs1,benzene_ring
+172425,Remove a amide from the molecule Cc1nc(-c2cccs2)sc1C(=O)N1c2ccccc2C[C@@H]1C.,Cc1nc(-c2cccs2)sc1C(=O)N1c2ccccc2C[C@@H]1C,amide
+215921,Please remove a amine from the molecule O=C(c1ccc(=O)n(Cc2ccccc2)n1)[n+]1ccccc1NC1CCCCC1.,O=C(c1ccc(=O)n(Cc2ccccc2)n1)[n+]1ccccc1NC1CCCCC1,amine
+181153,Please remove a hydroxyl from the molecule CCN(CCc1nccs1)Cc1cc(O)ccc1Br.,CCN(CCc1nccs1)Cc1cc(O)ccc1Br,hydroxyl
+151402,Remove a halo from the molecule Cc1cc(SCC(=O)Nc2ccc(Br)cc2)nc2ccc(S(=O)(=O)N(C)C)cc12.,Cc1cc(SCC(=O)Nc2ccc(Br)cc2)nc2ccc(S(=O)(=O)N(C)C)cc12,halo
+105429,Modify the molecule Cc1ccc([C@@H](C)[NH2+][C@@H](C)c2ccc(-n3ccnn3)cc2)cc1F by removing a benzene_ring.,Cc1ccc([C@@H](C)[NH2+][C@@H](C)c2ccc(-n3ccnn3)cc2)cc1F,benzene_ring
+170485,Remove a amide from the molecule CCCS(=O)(=O)[N-]c1cccc(NC(=O)c2ccccc2OC)c1C.,CCCS(=O)(=O)[N-]c1cccc(NC(=O)c2ccccc2OC)c1C,amide
+96649,Modify the molecule COC(=O)c1c(C)cc(C)cc1C by removing a benzene_ring.,COC(=O)c1c(C)cc(C)cc1C,benzene_ring
+228947,Remove a benzene_ring from the molecule O=S(=O)(c1ccccc1Cl)N(C[C@@H]1CCCO1)[C@@H]1CCSC1.,O=S(=O)(c1ccccc1Cl)N(C[C@@H]1CCCO1)[C@@H]1CCSC1,benzene_ring
+138411,Please remove a halo from the molecule Cc1ccccc1-n1cc(C(=O)N2CCC(OCc3ccc(F)cc3)CC2)cn1.,Cc1ccccc1-n1cc(C(=O)N2CCC(OCc3ccc(F)cc3)CC2)cn1,halo
+107363,Remove a halo from the molecule COc1ccc(N2C(=O)C[C@@H]([NH+]3CCC(c4ccc(O)cc4)CC3)C2=O)cc1Cl.,COc1ccc(N2C(=O)C[C@@H]([NH+]3CCC(c4ccc(O)cc4)CC3)C2=O)cc1Cl,halo
+46905,Remove a amide from the molecule CC(C)n1ncc2c(C(=O)N[C@H](C)c3ccc(NC(=O)c4ccc(F)cc4)cc3)cc(C3CC3)nc21.,CC(C)n1ncc2c(C(=O)N[C@H](C)c3ccc(NC(=O)c4ccc(F)cc4)cc3)cc(C3CC3)nc21,amide
+170756,Remove a benzene_ring from the molecule COc1cc(S(=O)(=O)CCO)cc(C(=O)[O-])c1OC.,COc1cc(S(=O)(=O)CCO)cc(C(=O)[O-])c1OC,benzene_ring
+45948,Please remove a halo from the molecule Cc1cc(C(=O)NCc2nnc3n2CC[NH+](Cc2c(F)ccc(F)c2F)CC3)c(C)o1.,Cc1cc(C(=O)NCc2nnc3n2CC[NH+](Cc2c(F)ccc(F)c2F)CC3)c(C)o1,halo
+159865,Please remove a benzene_ring from the molecule c1ccc(CCCCc2ccccc2)cc1.,c1ccc(CCCCc2ccccc2)cc1,benzene_ring
+150102,Remove a amide from the molecule CO[C@@H](CNC(=O)[C@@H]1CCC(=O)N1)c1ccc(F)cc1.,CO[C@@H](CNC(=O)[C@@H]1CCC(=O)N1)c1ccc(F)cc1,amide
+228566,Remove a amide from the molecule Cc1ccc(-n2ccnc2SCC(=O)N2CCC[C@H](C(N)=O)C2)cc1C.,Cc1ccc(-n2ccnc2SCC(=O)N2CCC[C@H](C(N)=O)C2)cc1C,amide
+123571,Modify the molecule CNC(=O)CC1CCN(C(=O)c2ccc(F)cc2)CC1 by removing a amide.,CNC(=O)CC1CCN(C(=O)c2ccc(F)cc2)CC1,amide
+49624,Modify the molecule Cc1nc(C(C)C)[nH]c(=O)c1C(=O)N(C)CC(=O)[O-] by removing a amide.,Cc1nc(C(C)C)[nH]c(=O)c1C(=O)N(C)CC(=O)[O-],amide
+192416,Modify the molecule Cc1cc(-c2ccc(S(=O)(=O)NC3CCCC3)s2)[nH]n1 by removing a amine.,Cc1cc(-c2ccc(S(=O)(=O)NC3CCCC3)s2)[nH]n1,amine
+55626,Modify the molecule CSc1ccccc1NC(=O)CSc1ccc(F)cc1N by removing a amine.,CSc1ccccc1NC(=O)CSc1ccc(F)cc1N,amine
+189662,Please remove a benzene_ring from the molecule NC(=O)c1ccc(CSCCOc2cccc(F)c2)cc1.,NC(=O)c1ccc(CSCCOc2cccc(F)c2)cc1,benzene_ring
+11653,Remove a amide from the molecule O=C(Cc1csc(NC(=O)c2cnccn2)n1)Nc1ccccc1.,O=C(Cc1csc(NC(=O)c2cnccn2)n1)Nc1ccccc1,amide
+90796,Remove a benzene_ring from the molecule C[C@H]1CN(C2=NC(=O)/C(=C\c3ccc4noc(-c5ccccc5)c4c3)S2)C[C@@H](C)O1.,C[C@H]1CN(C2=NC(=O)/C(=C\c3ccc4noc(-c5ccccc5)c4c3)S2)C[C@@H](C)O1,benzene_ring
+155123,Remove a amide from the molecule COc1cccc(C(=O)NCCc2nc3c(s2)CCCC3)c1OC.,COc1cccc(C(=O)NCCc2nc3c(s2)CCCC3)c1OC,amide
+180852,Remove a halo from the molecule CC(C)[C@@H](NC(=O)c1cccc(Cl)c1)C(=O)N1CCOCC1.,CC(C)[C@@H](NC(=O)c1cccc(Cl)c1)C(=O)N1CCOCC1,halo
+33187,Please remove a amine from the molecule CNS(=O)(=O)c1cccc(C(=O)N(C)Cc2cnn(C)c2)c1.,CNS(=O)(=O)c1cccc(C(=O)N(C)Cc2cnn(C)c2)c1,amine
+187415,Please remove a benzene_ring from the molecule Fc1cccc(CN2CCC[C@@H](c3nnc(-c4cccnc4)o3)C2)c1F.,Fc1cccc(CN2CCC[C@@H](c3nnc(-c4cccnc4)o3)C2)c1F,benzene_ring
+25860,Remove a amide from the molecule O=C1[C@H](c2ccncc2)N(Cc2ccco2)C(=O)CN1c1ccccc1.,O=C1[C@H](c2ccncc2)N(Cc2ccco2)C(=O)CN1c1ccccc1,amide
+143770,Remove a amide from the molecule C/C(=N/NC(=O)CN(c1cccc(Br)c1)S(C)(=O)=O)c1ccc(F)cc1.,C/C(=N/NC(=O)CN(c1cccc(Br)c1)S(C)(=O)=O)c1ccc(F)cc1,amide
+224494,Remove a hydroxyl from the molecule C[C@@](O)(CNC(=O)CCn1cc([N+](=O)[O-])cn1)c1ccc(F)cc1.,C[C@@](O)(CNC(=O)CCn1cc([N+](=O)[O-])cn1)c1ccc(F)cc1,hydroxyl
+145362,Remove a benzene_ring from the molecule CCc1ccc(-n2c(SCC(=O)c3ccc[nH]3)nnc2-c2ccncc2)cc1.,CCc1ccc(-n2c(SCC(=O)c3ccc[nH]3)nnc2-c2ccncc2)cc1,benzene_ring
+30885,Remove a benzene_ring from the molecule CSc1ccc(/C=C(/C)C[NH2+]CC(C)C)cc1.,CSc1ccc(/C=C(/C)C[NH2+]CC(C)C)cc1,benzene_ring
+245791,Modify the molecule O=C(Nc1nnc(Cc2ccccc2)s1)[C@@H]1CC(=O)N(Cc2ccccc2)C1 by removing a benzene_ring.,O=C(Nc1nnc(Cc2ccccc2)s1)[C@@H]1CC(=O)N(Cc2ccccc2)C1,benzene_ring
+82380,Modify the molecule CCc1cc(I)ccc1NC(=O)c1ccccc1F by removing a halo.,CCc1cc(I)ccc1NC(=O)c1ccccc1F,halo
+38213,Remove a halo from the molecule CC[C@H](Nc1nccn2cnnc12)c1ccccc1OC(F)F.,CC[C@H](Nc1nccn2cnnc12)c1ccccc1OC(F)F,halo
+117146,Remove a amide from the molecule CC(C)Cn1c(SCC(=O)Nc2ccc3[nH]c(=O)[nH]c3c2)nc2ccccc21.,CC(C)Cn1c(SCC(=O)Nc2ccc3[nH]c(=O)[nH]c3c2)nc2ccccc21,amide
+77285,Remove a amide from the molecule Cc1ccccc1-n1ncc2c(O)nc(SCC(=O)N3C[C@H](C)O[C@@H](C)C3)nc21.,Cc1ccccc1-n1ncc2c(O)nc(SCC(=O)N3C[C@H](C)O[C@@H](C)C3)nc21,amide
+166130,Modify the molecule Cc1cccc(NC(=O)N[C@@H]2CCCc3c2cnn3Cc2ccccc2)c1C by removing a benzene_ring.,Cc1cccc(NC(=O)N[C@@H]2CCCc3c2cnn3Cc2ccccc2)c1C,benzene_ring
+241405,Remove a benzene_ring from the molecule O=[S@]1N/C(=C/c2ccc(Cl)cc2)NO1.,O=[S@]1N/C(=C/c2ccc(Cl)cc2)NO1,benzene_ring
+14411,Please remove a benzene_ring from the molecule CC(=O)c1ccc(OC[C@@H](O)CN2CCN(c3ccccc3)CC2)cc1.,CC(=O)c1ccc(OC[C@@H](O)CN2CCN(c3ccccc3)CC2)cc1,benzene_ring
+118311,Please remove a amide from the molecule CCOC(=O)N1CCC[C@@H](C(=O)NCC(C)(C)c2ccncc2)C1.,CCOC(=O)N1CCC[C@@H](C(=O)NCC(C)(C)c2ccncc2)C1,amide
+112657,Remove a benzene_ring from the molecule COc1ccc(-c2csc(/C(C#N)=C\c3ccc(OCC#N)cc3)n2)cc1.,COc1ccc(-c2csc(/C(C#N)=C\c3ccc(OCC#N)cc3)n2)cc1,benzene_ring
+144227,Please remove a amide from the molecule COc1ccc(NC(=O)C(=O)N[C@@H](C)c2cc3ccccc3o2)cn1.,COc1ccc(NC(=O)C(=O)N[C@@H](C)c2cc3ccccc3o2)cn1,amide
+83061,Please remove a amide from the molecule Nc1cccc(C(=O)N[C@@H]2C=C[C@@H](C(=O)[O-])C2)c1.,Nc1cccc(C(=O)N[C@@H]2C=C[C@@H](C(=O)[O-])C2)c1,amide
+154935,Remove a nitro from the molecule C[C@H]1CN(c2ccc([N+](=O)[O-])cc2F)CC[NH2+]1.,C[C@H]1CN(c2ccc([N+](=O)[O-])cc2F)CC[NH2+]1,nitro
+67572,Please remove a hydroxyl from the molecule CC(C)[NH2+]Cc1ccc(S[C@H](C)CCO)c(F)c1.,CC(C)[NH2+]Cc1ccc(S[C@H](C)CCO)c(F)c1,hydroxyl
+55703,Remove a amide from the molecule COCCNC(=O)NC(=O)C[NH+]1Cc2ccccc2N(C)C[C@@H]1C.,COCCNC(=O)NC(=O)C[NH+]1Cc2ccccc2N(C)C[C@@H]1C,amide
+95423,Please remove a amide from the molecule CC(C)(C)c1ccccc1OCC(=O)NC1CC[NH+]([C@@H]2CCOC2)CC1.,CC(C)(C)c1ccccc1OCC(=O)NC1CC[NH+]([C@@H]2CCOC2)CC1,amide
+219953,Modify the molecule NC(=O)CCCNC(=O)C1(c2ccc3c(c2)OCO3)CCCCC1 by removing a amide.,NC(=O)CCCNC(=O)C1(c2ccc3c(c2)OCO3)CCCCC1,amide
+18803,Please remove a amide from the molecule COCCNC(=O)Cc1c(C)c2cc3c(C)c(C)oc3c(C)c2oc1=O.,COCCNC(=O)Cc1c(C)c2cc3c(C)c(C)oc3c(C)c2oc1=O,amide
+125986,Remove a halo from the molecule Cc1nn(Cc2ccccc2)c(Cl)c1C(=O)NC[C@@H](c1cccs1)N(C)C.,Cc1nn(Cc2ccccc2)c(Cl)c1C(=O)NC[C@@H](c1cccs1)N(C)C,halo
+51640,Remove a benzene_ring from the molecule O=CN[C@H]1CCCC[C@@H]1c1ccc([C@H]2CCCC[C@@H]2NC=O)cc1.,O=CN[C@H]1CCCC[C@@H]1c1ccc([C@H]2CCCC[C@@H]2NC=O)cc1,benzene_ring
+76112,Please remove a nitrile from the molecule COc1ccc(NC(=O)/C(C#N)=C/c2c(Oc3ccccc3F)nc3ccccn3c2=O)cc1.,COc1ccc(NC(=O)/C(C#N)=C/c2c(Oc3ccccc3F)nc3ccccn3c2=O)cc1,nitrile
+187310,Remove a halo from the molecule Cc1cccc2cc(CN(Cc3cccnc3)C(=S)Nc3cccc(Cl)c3)c(=O)[nH]c12.,Cc1cccc2cc(CN(Cc3cccnc3)C(=S)Nc3cccc(Cl)c3)c(=O)[nH]c12,halo
+33103,Remove a amine from the molecule c1ccc2c(c1)CC[C@@H](N[C@@H]1CC[NH2+]C1)C2.,c1ccc2c(c1)CC[C@@H](N[C@@H]1CC[NH2+]C1)C2,amine
+181264,Please remove a halo from the molecule COc1ccc(C)cc1CCNC(=O)C(=O)Nc1cc(F)ccc1OC.,COc1ccc(C)cc1CCNC(=O)C(=O)Nc1cc(F)ccc1OC,halo
+100731,Modify the molecule Cc1cc(N)cc(Cl)c1[NH+]1CCC(C)CC1 by removing a amine.,Cc1cc(N)cc(Cl)c1[NH+]1CCC(C)CC1,amine
+48466,Remove a nitro from the molecule O=c1oc2cc([N+](=O)[O-])ccc2n1Cc1noc(-c2cccs2)n1.,O=c1oc2cc([N+](=O)[O-])ccc2n1Cc1noc(-c2cccs2)n1,nitro
+181613,Remove a amide from the molecule Cc1cccc(NC(=O)NC(=O)c2ccc3ccccc3c2)c1.,Cc1cccc(NC(=O)NC(=O)c2ccc3ccccc3c2)c1,amide
+183109,Please remove a benzene_ring from the molecule CC[C@@H]([NH2+]Cc1cccc(-c2n[nH]c(C)n2)c1)c1ccc2c(c1)OCCO2.,CC[C@@H]([NH2+]Cc1cccc(-c2n[nH]c(C)n2)c1)c1ccc2c(c1)OCCO2,benzene_ring
+119420,Please remove a halo from the molecule C[C@H]1C[C@H](N2CCC(O)(C(F)(F)F)CC2)C(=O)O1.,C[C@H]1C[C@H](N2CCC(O)(C(F)(F)F)CC2)C(=O)O1,halo
+205431,Please remove a amide from the molecule Cc1noc(C)c1[C@@H](C)NC(=O)c1ccccc1NC(=O)NC(C)C.,Cc1noc(C)c1[C@@H](C)NC(=O)c1ccccc1NC(=O)NC(C)C,amide
+159824,Remove a nitro from the molecule O=[N+]([O-])c1ccc2nc(NC3CCC3)oc2c1.,O=[N+]([O-])c1ccc2nc(NC3CCC3)oc2c1,nitro
+151431,Remove a amide from the molecule Cc1nc(C2(NC(=O)Cc3csc(-n4c(C)ccc4C)n3)CCCC2)no1.,Cc1nc(C2(NC(=O)Cc3csc(-n4c(C)ccc4C)n3)CCCC2)no1,amide
+103432,Modify the molecule CC[NH2+]C[C@@H]1CCCC[NH+]1Cc1ccccc1 by removing a benzene_ring.,CC[NH2+]C[C@@H]1CCCC[NH+]1Cc1ccccc1,benzene_ring
+171885,Please remove a hydroxyl from the molecule C[C@@H](Cc1cccs1)[NH+](C)C[C@H](O)c1ccc(N)cc1.,C[C@@H](Cc1cccs1)[NH+](C)C[C@H](O)c1ccc(N)cc1,hydroxyl
+78514,Please remove a benzene_ring from the molecule Cc1nccn1-c1ccc(C(=O)/C=C/C2=Cc3ccccc3OC2)cc1.,Cc1nccn1-c1ccc(C(=O)/C=C/C2=Cc3ccccc3OC2)cc1,benzene_ring
+122584,Remove a amide from the molecule O=C(Cn1cc([N+](=O)[O-])cn1)N1CCCC1.,O=C(Cn1cc([N+](=O)[O-])cn1)N1CCCC1,amide
+125048,Modify the molecule [NH3+]CCOCC(=O)N[C@H](C(=O)[O-])C1CCCCC1 by removing a amide.,[NH3+]CCOCC(=O)N[C@H](C(=O)[O-])C1CCCCC1,amide
+157978,Modify the molecule O=C(CSc1nnc(C2CC2)n1C1CC1)N1CCN(Cc2ccccc2)CC1 by removing a benzene_ring.,O=C(CSc1nnc(C2CC2)n1C1CC1)N1CCN(Cc2ccccc2)CC1,benzene_ring
+105704,Remove a halo from the molecule FC(F)(F)CCc1noc(COC2CC[NH2+]CC2)n1.,FC(F)(F)CCc1noc(COC2CC[NH2+]CC2)n1,halo
+218812,Please remove a nitrile from the molecule C[C@@H](CN1CCOCC1)[NH+]1CCC(Oc2cccc(C#N)c2)CC1.,C[C@@H](CN1CCOCC1)[NH+]1CCC(Oc2cccc(C#N)c2)CC1,nitrile
+105136,Remove a benzene_ring from the molecule COc1ccc(OC)c([C@@H](C)NC(=O)Nc2c(F)cccc2F)c1.,COc1ccc(OC)c([C@@H](C)NC(=O)Nc2c(F)cccc2F)c1,benzene_ring
+84260,Please remove a amine from the molecule C/C(NC[C@@H]1CCCO1)=C1\C(=O)NC(=O)N(C2CCCCC2)C1=O.,C/C(NC[C@@H]1CCCO1)=C1\C(=O)NC(=O)N(C2CCCCC2)C1=O,amine
+20150,Modify the molecule Nc1c(NNC(=O)c2ccc(Cl)cc2Cl)ncnc1NC1CCCCC1 by removing a amine.,Nc1c(NNC(=O)c2ccc(Cl)cc2Cl)ncnc1NC1CCCCC1,amine
+228484,Please remove a benzene_ring from the molecule CCc1ccc(NC(=O)[C@H](C)Oc2ccc(OC)cc2)cc1.,CCc1ccc(NC(=O)[C@H](C)Oc2ccc(OC)cc2)cc1,benzene_ring
+239722,Modify the molecule COc1ccc(C[C@@H](C)[NH3+])cc1OCc1cccc(C)n1 by removing a benzene_ring.,COc1ccc(C[C@@H](C)[NH3+])cc1OCc1cccc(C)n1,benzene_ring
+115818,Please remove a halo from the molecule CCC[NH+]1CCC[C@H]([C@@H](C)NCc2ccc(Br)cc2)C1.,CCC[NH+]1CCC[C@H]([C@@H](C)NCc2ccc(Br)cc2)C1,halo
+14020,Modify the molecule CCc1ccc(NC(=O)[C@H](C)[S@@](=O)Cc2nc(C)c(C)s2)cc1 by removing a amide.,CCc1ccc(NC(=O)[C@H](C)[S@@](=O)Cc2nc(C)c(C)s2)cc1,amide
+243620,Please remove a amide from the molecule COc1ccccc1[C@H](NC(=O)c1ccn(C)c(=O)c1)c1ccccn1.,COc1ccccc1[C@H](NC(=O)c1ccn(C)c(=O)c1)c1ccccn1,amide
+152160,Modify the molecule C[C@H](C#N)Oc1ccc(C[NH+](C)Cc2csc(Br)c2)cc1 by removing a nitrile.,C[C@H](C#N)Oc1ccc(C[NH+](C)Cc2csc(Br)c2)cc1,nitrile
+6257,Please remove a benzene_ring from the molecule O=C(CN1CCO[C@@H](c2cccs2)C1)NOCc1ccccc1.,O=C(CN1CCO[C@@H](c2cccs2)C1)NOCc1ccccc1,benzene_ring
+201966,Remove a benzene_ring from the molecule CC(=O)NCc1ccc(C(=O)NCc2csc(-c3ccccc3)n2)cc1.,CC(=O)NCc1ccc(C(=O)NCc2csc(-c3ccccc3)n2)cc1,benzene_ring
+83531,Modify the molecule COC(=O)C[C@H](NC(=O)c1cccc(N2CCCS2(=O)=O)c1)c1ccc(Br)cc1 by removing a benzene_ring.,COC(=O)C[C@H](NC(=O)c1cccc(N2CCCS2(=O)=O)c1)c1ccc(Br)cc1,benzene_ring
+159255,Please remove a amide from the molecule Cc1cc(C)c2sc(N(Cc3ccccc3)C(=O)CC[C@@H]3CCCO3)nc2c1.,Cc1cc(C)c2sc(N(Cc3ccccc3)C(=O)CC[C@@H]3CCCO3)nc2c1,amide
+108007,Please remove a halo from the molecule Cc1c(C(=O)N2CCOC[C@@H]2C2CC2)sc2ccc(F)cc12.,Cc1c(C(=O)N2CCOC[C@@H]2C2CC2)sc2ccc(F)cc12,halo
+122393,Remove a benzene_ring from the molecule CC[C@H](NC(=O)N1CC=C(c2cccc(C)c2)CC1)c1ccncc1.,CC[C@H](NC(=O)N1CC=C(c2cccc(C)c2)CC1)c1ccncc1,benzene_ring
+10174,Modify the molecule CCN(C(=O)C1CC=CC1)c1ccc(F)c(F)c1 by removing a amide.,CCN(C(=O)C1CC=CC1)c1ccc(F)c(F)c1,amide
+188926,Modify the molecule COc1ccc(NC(=O)NCCN2C[C@@H](C)O[C@H](C)C2)c([N+](=O)[O-])c1 by removing a nitro.,COc1ccc(NC(=O)NCCN2C[C@@H](C)O[C@H](C)C2)c([N+](=O)[O-])c1,nitro
+16277,Remove a amide from the molecule C#CCN(CC(=O)[O-])C(=O)c1nc(CC)n[n-]1.,C#CCN(CC(=O)[O-])C(=O)c1nc(CC)n[n-]1,amide
+14552,Remove a amine from the molecule C/[NH+]=C(/NCCN1CCc2sccc2C1)NCc1cccs1.,C/[NH+]=C(/NCCN1CCc2sccc2C1)NCc1cccs1,amine
+125781,Please remove a benzene_ring from the molecule CO[C@H](C(=O)N1CCC(n2cc(C(=O)NC3CCCC3)nn2)CC1)c1ccccc1.,CO[C@H](C(=O)N1CCC(n2cc(C(=O)NC3CCCC3)nn2)CC1)c1ccccc1,benzene_ring
+38931,Modify the molecule COCCN(CC(F)(F)F)C(=O)[C@H]1C[C@H]1c1ccccc1 by removing a halo.,COCCN(CC(F)(F)F)C(=O)[C@H]1C[C@H]1c1ccccc1,halo
+160770,Please remove a amide from the molecule C[C@H]1CSC(SCC(=O)N2CCC(Cc3ccccc3)CC2)=N1.,C[C@H]1CSC(SCC(=O)N2CCC(Cc3ccccc3)CC2)=N1,amide
+15574,Please remove a benzene_ring from the molecule O=C(NN1C(=O)NC(c2ccccc2)(c2ccccc2)C1=O)c1csc(-c2cccs2)n1.,O=C(NN1C(=O)NC(c2ccccc2)(c2ccccc2)C1=O)c1csc(-c2cccs2)n1,benzene_ring
+111912,Modify the molecule COc1cccc(/C=C/C(=O)NNC(=O)c2cc(-c3ccccc3)n[nH]2)c1 by removing a amide.,COc1cccc(/C=C/C(=O)NNC(=O)c2cc(-c3ccccc3)n[nH]2)c1,amide
+149581,Modify the molecule CCc1n[nH]c(=O)c(CNC(=O)c2ccc(-n3ccnn3)cc2)c1CC by removing a benzene_ring.,CCc1n[nH]c(=O)c(CNC(=O)c2ccc(-n3ccnn3)cc2)c1CC,benzene_ring
+244938,Remove a amide from the molecule COc1cccc(CN(C)C(=O)Cn2ncnc2-c2cccc(C#N)c2)c1.,COc1cccc(CN(C)C(=O)Cn2ncnc2-c2cccc(C#N)c2)c1,amide
+213262,Please remove a amide from the molecule COc1cccc2sc(NC(=O)[C@H](C)OC)nc12.,COc1cccc2sc(NC(=O)[C@H](C)OC)nc12,amide
+93751,Remove a halo from the molecule COc1ccc(C[NH2+]Cc2c(C)nn(Cc3ccccc3Cl)c2Cl)cn1.,COc1ccc(C[NH2+]Cc2c(C)nn(Cc3ccccc3Cl)c2Cl)cn1,halo
+184306,Modify the molecule COC(=O)[C@H]1CCN(C(=O)[C@@H](Oc2cccc(Cl)c2)C(C)C)C1 by removing a halo.,COC(=O)[C@H]1CCN(C(=O)[C@@H](Oc2cccc(Cl)c2)C(C)C)C1,halo
+187307,Please remove a amide from the molecule CCC(=O)Nc1nc2c(c3c1c(=O)oc1ccccc13)C[C@@H](C)CC2.,CCC(=O)Nc1nc2c(c3c1c(=O)oc1ccccc13)C[C@@H](C)CC2,amide
+234480,Remove a amide from the molecule CCc1cnc(CCNC(=O)CO[C@@H]2CCC[C@H](C)C2)s1.,CCc1cnc(CCNC(=O)CO[C@@H]2CCC[C@H](C)C2)s1,amide
+186188,Modify the molecule CC[NH2+][C@H](C)[C@@H]1CCCCN1c1ccc(C(N)=O)cn1 by removing a amide.,CC[NH2+][C@H](C)[C@@H]1CCCCN1c1ccc(C(N)=O)cn1,amide
+34562,Please remove a benzene_ring from the molecule C[NH2+]Cc1cc(C)n(-c2ccc(OC)cc2)c1C.,C[NH2+]Cc1cc(C)n(-c2ccc(OC)cc2)c1C,benzene_ring
+229276,Remove a amide from the molecule CCCN(C(C)C)[C@H](C[NH3+])CC(N)=O.,CCCN(C(C)C)[C@H](C[NH3+])CC(N)=O,amide
+31233,Remove a benzene_ring from the molecule N#CCc1ccc(Oc2ccc(F)cc2C=O)cc1.,N#CCc1ccc(Oc2ccc(F)cc2C=O)cc1,benzene_ring
+99197,Please remove a amide from the molecule O=C(C[NH+]1CC(c2nc(-c3cccnc3)no2)C1)N1CCCC1.,O=C(C[NH+]1CC(c2nc(-c3cccnc3)no2)C1)N1CCCC1,amide
+201740,Remove a benzene_ring from the molecule CCn1c([C@@H](C)[NH2+][C@@H](C)c2cccc(NC(C)=O)c2)nc2ccccc21.,CCn1c([C@@H](C)[NH2+][C@@H](C)c2cccc(NC(C)=O)c2)nc2ccccc21,benzene_ring
+803,Please remove a amide from the molecule C[C@H](CNC(=O)c1ccc(-c2ccccc2)[nH]c1=O)Oc1ccc(F)cc1.,C[C@H](CNC(=O)c1ccc(-c2ccccc2)[nH]c1=O)Oc1ccc(F)cc1,amide
+2151,Remove a benzene_ring from the molecule O=C(CS[C@H]1NN=C(C[C@@H]2CCS(=O)(=O)C2)O1)C1=c2ccccc2=[NH+][C@@H]1c1ccccc1.,O=C(CS[C@H]1NN=C(C[C@@H]2CCS(=O)(=O)C2)O1)C1=c2ccccc2=[NH+][C@@H]1c1ccccc1,benzene_ring
+48603,Remove a amine from the molecule Cc1nc(C[C@@H]2CCCN(C(=O)CCc3ccccc3)C2)cc(Nc2ncc(C)s2)n1.,Cc1nc(C[C@@H]2CCCN(C(=O)CCc3ccccc3)C2)cc(Nc2ncc(C)s2)n1,amine
+241913,Remove a nitrile from the molecule Cc1cc2c(c(=O)o1)[C@@H](c1ccc(Cl)c(Cl)c1)C(C#N)=C(N)O2.,Cc1cc2c(c(=O)o1)[C@@H](c1ccc(Cl)c(Cl)c1)C(C#N)=C(N)O2,nitrile
+67828,Remove a benzene_ring from the molecule O=C(Cc1ccc(S(=O)(=O)N2CCCCC2)s1)Nc1ccc(F)cc1F.,O=C(Cc1ccc(S(=O)(=O)N2CCCCC2)s1)Nc1ccc(F)cc1F,benzene_ring
+63575,Please remove a amide from the molecule Cc1cc2oc(Br)c(CC(=O)N3CCOCC3)c2cc1Cl.,Cc1cc2oc(Br)c(CC(=O)N3CCOCC3)c2cc1Cl,amide
+135819,Remove a amide from the molecule COc1ccc(-c2ccc(=O)n([C@H](C)C(=O)Nc3nc4ccc(Cl)cc4s3)n2)cc1.,COc1ccc(-c2ccc(=O)n([C@H](C)C(=O)Nc3nc4ccc(Cl)cc4s3)n2)cc1,amide
+119186,Please remove a amide from the molecule CC[NH+](CC)C[C@H]1CCN(C(=O)[C@@H]2CN(Cc3ccccc3)CCO2)C1.,CC[NH+](CC)C[C@H]1CCN(C(=O)[C@@H]2CN(Cc3ccccc3)CCO2)C1,amide
+109940,Please remove a benzene_ring from the molecule [NH3+]CC(=O)N1CCCC[C@@H]1CNC(=O)OCc1ccccc1.,[NH3+]CC(=O)N1CCCC[C@@H]1CNC(=O)OCc1ccccc1,benzene_ring
+123914,Please remove a amide from the molecule CO[C@H]1CCCC[C@H]1NC(=O)c1cnc(C)c(Cl)c1Br.,CO[C@H]1CCCC[C@H]1NC(=O)c1cnc(C)c(Cl)c1Br,amide
+208901,Remove a halo from the molecule Cc1cc(C[NH2+]Cc2ccc3c(c2)CCC3)cc(C)c1F.,Cc1cc(C[NH2+]Cc2ccc3c(c2)CCC3)cc(C)c1F,halo
+173565,Remove a hydroxyl from the molecule CCCCn1ncc(C(=O)N[C@@H](CO)c2ccco2)c1C.,CCCCn1ncc(C(=O)N[C@@H](CO)c2ccco2)c1C,hydroxyl
+139831,Modify the molecule Cc1cc(N)cc(S(=O)(=O)Nc2cc(C)ccc2F)c1 by removing a benzene_ring.,Cc1cc(N)cc(S(=O)(=O)Nc2cc(C)ccc2F)c1,benzene_ring
+140904,Modify the molecule CC(=O)Nc1ccccc1C[NH+]1CC[C@H](c2ccccc2)[C@@H](C)C1 by removing a amide.,CC(=O)Nc1ccccc1C[NH+]1CC[C@H](c2ccccc2)[C@@H](C)C1,amide
+126478,Remove a halo from the molecule O=C(CCC(=O)c1ccc(F)cc1)OCc1cc2c(cc1Br)OCCO2.,O=C(CCC(=O)c1ccc(F)cc1)OCc1cc2c(cc1Br)OCCO2,halo
+79958,Modify the molecule COc1ccccc1C[C@@H](C)N(C)C(=O)N[C@@H]1CCC[C@H](SC)C1 by removing a benzene_ring.,COc1ccccc1C[C@@H](C)N(C)C(=O)N[C@@H]1CCC[C@H](SC)C1,benzene_ring
+33905,Please remove a amide from the molecule CCOc1ccc(S(=O)(=O)Nc2ccc(C(=O)N(C)C)c(C)c2)cc1.,CCOc1ccc(S(=O)(=O)Nc2ccc(C(=O)N(C)C)c(C)c2)cc1,amide
+215467,Remove a halo from the molecule Cc1cc(NC(=O)[C@@]2(C)Oc3ccc(Cl)cc3NC2=O)no1.,Cc1cc(NC(=O)[C@@]2(C)Oc3ccc(Cl)cc3NC2=O)no1,halo
+102351,Remove a amide from the molecule COC(=O)C[C@H]1CCCCN1C(=O)c1nc2nccc(C)n2n1.,COC(=O)C[C@H]1CCCCN1C(=O)c1nc2nccc(C)n2n1,amide
+120800,Remove a benzene_ring from the molecule CC(=O)Nc1ccc(C[NH+]2CCC(C3CCOCC3)CC2)cc1.,CC(=O)Nc1ccc(C[NH+]2CCC(C3CCOCC3)CC2)cc1,benzene_ring
+132235,Remove a amide from the molecule Cc1cc(C(=O)N2CCN(Cc3ccc([C@@H]4C[C@@H]4C)o3)CC2)on1.,Cc1cc(C(=O)N2CCN(Cc3ccc([C@@H]4C[C@@H]4C)o3)CC2)on1,amide
+63115,Remove a benzene_ring from the molecule O=C(NNc1ccc(F)cc1)Nc1ccc(C(=O)Nc2ccccc2)cc1.,O=C(NNc1ccc(F)cc1)Nc1ccc(C(=O)Nc2ccccc2)cc1,benzene_ring
+144693,Modify the molecule COc1ccc([C@@H]2CCCN2C(=O)COc2cc(C)ccc2F)cc1 by removing a benzene_ring.,COc1ccc([C@@H]2CCCN2C(=O)COc2cc(C)ccc2F)cc1,benzene_ring
+248359,Please remove a halo from the molecule Cc1cccc(N2C(=O)CSC23CCN(C(=O)CCl)CC3)c1.,Cc1cccc(N2C(=O)CSC23CCN(C(=O)CCl)CC3)c1,halo
+167259,Remove a halo from the molecule CCn1nc(C)c(Cl)c1C[C@H](C[NH3+])c1ccccc1Br.,CCn1nc(C)c(Cl)c1C[C@H](C[NH3+])c1ccccc1Br,halo
+108031,Remove a amine from the molecule CC1CC[NH+](CCCNCc2cn(C)nc2C(C)(C)C)CC1.,CC1CC[NH+](CCCNCc2cn(C)nc2C(C)(C)C)CC1,amine
+212278,Modify the molecule Cc1ccccc1Nc1nc(CSc2nnc(C)n2C2CC2)cs1 by removing a benzene_ring.,Cc1ccccc1Nc1nc(CSc2nnc(C)n2C2CC2)cs1,benzene_ring
+106004,Modify the molecule CC(C)[NH+]1CC[C@H](NS(=O)(=O)c2cccc(C(F)(F)F)c2)C1 by removing a amine.,CC(C)[NH+]1CC[C@H](NS(=O)(=O)c2cccc(C(F)(F)F)c2)C1,amine
+222728,Remove a amide from the molecule C[C@@H]1CCCCN1C(=O)[C@@H](C)n1nc(-c2ccccc2)ccc1=O.,C[C@@H]1CCCCN1C(=O)[C@@H](C)n1nc(-c2ccccc2)ccc1=O,amide
+7249,Modify the molecule CCOc1ccccc1NC(=O)COC(=O)c1c2c(nc3ccccc13)CC[C@@H](C)C2 by removing a benzene_ring.,CCOc1ccccc1NC(=O)COC(=O)c1c2c(nc3ccccc13)CC[C@@H](C)C2,benzene_ring
+53004,Remove a amide from the molecule CCS(=O)(=O)CCN(C)C(=O)CC[C@@H]1CCCOC1.,CCS(=O)(=O)CCN(C)C(=O)CC[C@@H]1CCCOC1,amide
+160577,Please remove a benzene_ring from the molecule CCOC(=O)c1ccc(N/C([O-])=C(\C#N)C(=O)c2ccc(C)c(C)c2)cc1.,CCOC(=O)c1ccc(N/C([O-])=C(\C#N)C(=O)c2ccc(C)c(C)c2)cc1,benzene_ring
+74786,Remove a amide from the molecule Cc1ccc(N2CCN(C(=O)CCc3cc([O-])no3)CC2=O)cc1.,Cc1ccc(N2CCN(C(=O)CCc3cc([O-])no3)CC2=O)cc1,amide
+233074,Remove a benzene_ring from the molecule O=c1cc(CS(=O)(=O)c2ccccc2)nc2ccccn12.,O=c1cc(CS(=O)(=O)c2ccccc2)nc2ccccn12,benzene_ring
+49131,Modify the molecule CC(C)CC(=O)Nc1cccc(CNC(=O)Nc2ccccc2N(C)C)c1 by removing a benzene_ring.,CC(C)CC(=O)Nc1cccc(CNC(=O)Nc2ccccc2N(C)C)c1,benzene_ring
+218923,Remove a halo from the molecule CN(C)C(=O)[C@@H](c1ccccc1)n1nnc(-c2ccc(F)cc2)n1.,CN(C)C(=O)[C@@H](c1ccccc1)n1nnc(-c2ccc(F)cc2)n1,halo
+246717,Please remove a benzene_ring from the molecule CC(C)Oc1ccc(CNC(=O)Nc2ccccc2OC(C)C)cn1.,CC(C)Oc1ccc(CNC(=O)Nc2ccccc2OC(C)C)cn1,benzene_ring
+242970,Please remove a amide from the molecule O=C(C1CC1)N1CCc2ccc(NS(=O)(=O)c3ccc([N+](=O)[O-])cc3)cc2C1.,O=C(C1CC1)N1CCc2ccc(NS(=O)(=O)c3ccc([N+](=O)[O-])cc3)cc2C1,amide
+34155,Please remove a benzene_ring from the molecule CN(CCOc1ccc(F)cc1Cl)S(=O)(=O)c1ccc(Cl)nc1.,CN(CCOc1ccc(F)cc1Cl)S(=O)(=O)c1ccc(Cl)nc1,benzene_ring
+145100,Remove a halo from the molecule CCOc1ccc2c(c1)s/c(=N\C(=O)c1ccccc1F)n2CCOC.,CCOc1ccc2c(c1)s/c(=N\C(=O)c1ccccc1F)n2CCOC,halo
+5203,Please remove a nitrile from the molecule CC(=O)Oc1ccc(/C=C(\C#N)C(=O)Nc2ccc([N+](=O)[O-])cc2Cl)cc1Br.,CC(=O)Oc1ccc(/C=C(\C#N)C(=O)Nc2ccc([N+](=O)[O-])cc2Cl)cc1Br,nitrile
+172623,Please remove a amide from the molecule CCC[C@H](C)NC(=O)[C@@H]1CCCN(C(=O)c2cc(F)cc(F)c2)C1.,CCC[C@H](C)NC(=O)[C@@H]1CCCN(C(=O)c2cc(F)cc(F)c2)C1,amide
+29833,Please remove a amine from the molecule CC[C@H](C)N/C(NCc1cccc([N+]2=CCCC2)c1)=[NH+]\C.,CC[C@H](C)N/C(NCc1cccc([N+]2=CCCC2)c1)=[NH+]\C,amine
+108859,Remove a amide from the molecule COc1ccc(NC(=O)/C=C/c2ccccc2[N+](=O)[O-])c2cccnc12.,COc1ccc(NC(=O)/C=C/c2ccccc2[N+](=O)[O-])c2cccnc12,amide
+146758,Please remove a halo from the molecule CN(C)c1cc(C(=O)Nc2cccc(Cl)c2Cl)ccn1.,CN(C)c1cc(C(=O)Nc2cccc(Cl)c2Cl)ccn1,halo
+240393,Please remove a benzene_ring from the molecule CCCc1ccc(-c2nc(NC(=O)Cc3c(C)[nH]c4ccnn4c3=O)sc2C)cc1.,CCCc1ccc(-c2nc(NC(=O)Cc3c(C)[nH]c4ccnn4c3=O)sc2C)cc1,benzene_ring
+16741,Remove a benzene_ring from the molecule COc1ccc(CC(=O)NNC(=O)c2oc3ccccc3c2C)cc1OC.,COc1ccc(CC(=O)NNC(=O)c2oc3ccccc3c2C)cc1OC,benzene_ring
+116395,Please remove a amide from the molecule COc1cc(NC(=O)c2cc(-c3cccc(OC)c3)n[nH]2)cc(OC)c1.,COc1cc(NC(=O)c2cc(-c3cccc(OC)c3)n[nH]2)cc(OC)c1,amide
+164111,Please remove a benzene_ring from the molecule CCOc1ccc(-c2cc(O)cc(C(F)(F)F)c2)c(C)c1.,CCOc1ccc(-c2cc(O)cc(C(F)(F)F)c2)c(C)c1,benzene_ring
+94738,Remove a amide from the molecule O=C([C@H]1Cc2[nH+]c[nH]c2CN1)N1CCC[NH+]2CCC[C@@H]2C1.,O=C([C@H]1Cc2[nH+]c[nH]c2CN1)N1CCC[NH+]2CCC[C@@H]2C1,amide
+194085,Remove a benzene_ring from the molecule CN(C1CC1)[C@@H](c1ccccc1)[C@H]([NH3+])Cc1ccccc1.,CN(C1CC1)[C@@H](c1ccccc1)[C@H]([NH3+])Cc1ccccc1,benzene_ring
+195910,Modify the molecule Cc1nc(C)n(-c2ccccc2NC(=O)N(C)C[C@H](C)c2ccccc2)n1 by removing a benzene_ring.,Cc1nc(C)n(-c2ccccc2NC(=O)N(C)C[C@H](C)c2ccccc2)n1,benzene_ring
+123651,Modify the molecule C[C@@H](NC(=O)c1cccc(Oc2cnccn2)c1)c1ccncc1 by removing a benzene_ring.,C[C@@H](NC(=O)c1cccc(Oc2cnccn2)c1)c1ccncc1,benzene_ring
+123258,Please remove a benzene_ring from the molecule Cc1ccc(S(=O)(=O)N2CCCCC2)cc1NC(=O)c1csc2c1CCCC2.,Cc1ccc(S(=O)(=O)N2CCCCC2)cc1NC(=O)c1csc2c1CCCC2,benzene_ring
+215388,Modify the molecule Cc1cc(C)cc(NC(=O)Cc2nc(C)c(C(=O)NCC(C)C)s2)c1 by removing a amide.,Cc1cc(C)cc(NC(=O)Cc2nc(C)c(C(=O)NCC(C)C)s2)c1,amide
+66335,Please remove a amide from the molecule CC(C)N(C(=O)CSc1cccc[n+]1[O-])c1ccccc1.,CC(C)N(C(=O)CSc1cccc[n+]1[O-])c1ccccc1,amide
+198604,Remove a halo from the molecule NC(=O)[C@@H]1CCC[C@@H]1NC(=O)NCC1(c2cccc(F)c2)CC1.,NC(=O)[C@@H]1CCC[C@@H]1NC(=O)NCC1(c2cccc(F)c2)CC1,halo
+55821,Please remove a benzene_ring from the molecule Oc1cc2c(cc1C[NH+]1CCN(c3cccc(C(F)(F)F)c3)CC1)CCC2.,Oc1cc2c(cc1C[NH+]1CCN(c3cccc(C(F)(F)F)c3)CC1)CCC2,benzene_ring
+245876,Remove a benzene_ring from the molecule Cc1n[nH]c2ncc(NC(=O)NC[C@@H](C)COCc3ccccc3)cc12.,Cc1n[nH]c2ncc(NC(=O)NC[C@@H](C)COCc3ccccc3)cc12,benzene_ring
+23265,Please remove a amide from the molecule CCCCN(C(=O)C[NH+](C)[C@@H]1CCC[C@H](C)C1)[C@H]1CCS(=O)(=O)C1.,CCCCN(C(=O)C[NH+](C)[C@@H]1CCC[C@H](C)C1)[C@H]1CCS(=O)(=O)C1,amide
+7308,Modify the molecule CC(C)C[C@@H](NC(=O)NC(C)C)C(=O)N1CCc2nnc(-c3ccccn3)n2CC1 by removing a amide.,CC(C)C[C@@H](NC(=O)NC(C)C)C(=O)N1CCc2nnc(-c3ccccn3)n2CC1,amide
+228095,Modify the molecule Cc1ccc([N-]S(=O)(=O)c2c(C)noc2C)cc1NC(=O)c1ccncc1 by removing a amide.,Cc1ccc([N-]S(=O)(=O)c2c(C)noc2C)cc1NC(=O)c1ccncc1,amide
+54007,Remove a halo from the molecule C[C@H]1c2ccsc2CCN1C(=O)c1cccc(S(=O)(=O)N(C)c2cccc(Cl)c2)c1.,C[C@H]1c2ccsc2CCN1C(=O)c1cccc(S(=O)(=O)N(C)c2cccc(Cl)c2)c1,halo
+107350,Remove a amide from the molecule Cc1cc(NC(=O)CCc2ncc(-c3c(F)cccc3F)o2)[nH]n1.,Cc1cc(NC(=O)CCc2ncc(-c3c(F)cccc3F)o2)[nH]n1,amide
+176579,Remove a benzene_ring from the molecule CCOc1cc(N2CCN(C(=O)Nc3cccc(F)c3)CC2)nc(C)n1.,CCOc1cc(N2CCN(C(=O)Nc3cccc(F)c3)CC2)nc(C)n1,benzene_ring
+239927,Modify the molecule O=C(Nc1ccc(Cl)cc1Cl)C(=O)N[C@@H]1CCSc2ccc(F)cc21 by removing a halo.,O=C(Nc1ccc(Cl)cc1Cl)C(=O)N[C@@H]1CCSc2ccc(F)cc21,halo
+9751,Modify the molecule COc1ccccc1NC(=O)C12C[C@@H]3C[C@H](C1)CC(n1cncn1)(C3)C2 by removing a amide.,COc1ccccc1NC(=O)C12C[C@@H]3C[C@H](C1)CC(n1cncn1)(C3)C2,amide
+215625,Please remove a benzene_ring from the molecule COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN(C(=O)N2CCCC2)C1.,COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN(C(=O)N2CCCC2)C1,benzene_ring
+223304,Please remove a benzene_ring from the molecule COc1cccc(C(=O)CN2CC[NH+]3CCC[C@@H]3C2)c1.,COc1cccc(C(=O)CN2CC[NH+]3CCC[C@@H]3C2)c1,benzene_ring
+140388,Remove a benzene_ring from the molecule Cc1ccc([C@H](O)Cc2nc3ccccc3n2C)c(C)c1.,Cc1ccc([C@H](O)Cc2nc3ccccc3n2C)c(C)c1,benzene_ring
+75689,Modify the molecule Nc1cc[nH+]c(Cn2nnc(-c3ccccc3)n2)c1 by removing a amine.,Nc1cc[nH+]c(Cn2nnc(-c3ccccc3)n2)c1,amine
+110272,Please remove a benzene_ring from the molecule COc1ccc(-c2cc([C@H]3CCCCC[NH+]3Cc3ccccn3)on2)cc1.,COc1ccc(-c2cc([C@H]3CCCCC[NH+]3Cc3ccccn3)on2)cc1,benzene_ring
+42912,Remove a halo from the molecule CC(C)(CSc1ccc(Br)cn1)C(=O)NN.,CC(C)(CSc1ccc(Br)cn1)C(=O)NN,halo
+20720,Modify the molecule Cc1ccc(/C=C/C(=O)N2CC[C@H](C(N)=O)c3ccccc32)o1 by removing a amide.,Cc1ccc(/C=C/C(=O)N2CC[C@H](C(N)=O)c3ccccc32)o1,amide
+33168,Modify the molecule CC[C@H](CCO)Nc1ccc2cc(Br)ccc2n1 by removing a amine.,CC[C@H](CCO)Nc1ccc2cc(Br)ccc2n1,amine
+231771,Modify the molecule O=C(C1CC1)N1CCC(C(=O)N2CCOc3ccc(CO)cc3C2)CC1 by removing a amide.,O=C(C1CC1)N1CCC(C(=O)N2CCOc3ccc(CO)cc3C2)CC1,amide
+168845,Remove a benzene_ring from the molecule Cc1ccncc1NC(=O)NCC[C@H](C)c1ccccc1.,Cc1ccncc1NC(=O)NCC[C@H](C)c1ccccc1,benzene_ring
+147016,Please remove a amide from the molecule COC(=O)c1c(CC(=O)Nc2ccccn2)[nH]c(C(C)=O)c1C.,COC(=O)c1c(CC(=O)Nc2ccccn2)[nH]c(C(C)=O)c1C,amide
+6484,Modify the molecule Cc1ccc(Oc2ccc(NC(=O)C(=O)NCc3ccnn3C)cn2)cc1C by removing a benzene_ring.,Cc1ccc(Oc2ccc(NC(=O)C(=O)NCc3ccnn3C)cn2)cc1C,benzene_ring
+29873,Remove a benzene_ring from the molecule CCN(CC)c1ccc(/C=C2/C(=N)N3C(SCc4ccccc4)=NSC3=NC2=O)cc1.,CCN(CC)c1ccc(/C=C2/C(=N)N3C(SCc4ccccc4)=NSC3=NC2=O)cc1,benzene_ring
+53106,Modify the molecule Cc1ccc(C(=O)N2CCN(Cc3cc(C#N)cs3)CC2)o1 by removing a amide.,Cc1ccc(C(=O)N2CCN(Cc3cc(C#N)cs3)CC2)o1,amide
+31263,Remove a hydroxyl from the molecule Cn1c(C[NH+](C)C[C@H](O)Cn2cccn2)nc2ccccc21.,Cn1c(C[NH+](C)C[C@H](O)Cn2cccn2)nc2ccccc21,hydroxyl
+106622,Please remove a hydroxyl from the molecule CC[NH2+]C[C@@H](O)CN1C(=O)CCCC1=O.,CC[NH2+]C[C@@H](O)CN1C(=O)CCCC1=O,hydroxyl
+133584,Remove a benzene_ring from the molecule CC[C@@H](C)[C@H](C[NH3+])c1c(Cl)cccc1Cl.,CC[C@@H](C)[C@H](C[NH3+])c1c(Cl)cccc1Cl,benzene_ring
+243868,Modify the molecule Cc1cc(C(=O)NCC[NH+]2CCC(c3ccsc3)CC2)ccc1[N+](=O)[O-] by removing a nitro.,Cc1cc(C(=O)NCC[NH+]2CCC(c3ccsc3)CC2)ccc1[N+](=O)[O-],nitro
+34400,Please remove a halo from the molecule Cc1ccc(C)c2[nH]c(=O)c(CN(Cc3ccco3)C(=S)Nc3cccc(Cl)c3)cc12.,Cc1ccc(C)c2[nH]c(=O)c(CN(Cc3ccco3)C(=S)Nc3cccc(Cl)c3)cc12,halo
+62315,Remove a amine from the molecule CCS(=O)(=O)NCC#CCOc1ccc2c(c1)OCO2.,CCS(=O)(=O)NCC#CCOc1ccc2c(c1)OCO2,amine
+244661,Remove a amide from the molecule C[NH+](C)Cc1cccc(CNC(=O)c2n[nH]c(C3CC3)c2Cl)c1.,C[NH+](C)Cc1cccc(CNC(=O)c2n[nH]c(C3CC3)c2Cl)c1,amide
+54900,Modify the molecule COc1ccc(Cl)cc1/N=C(/[S-])Nc1ccccc1C by removing a halo.,COc1ccc(Cl)cc1/N=C(/[S-])Nc1ccccc1C,halo
+213230,Please remove a amine from the molecule COc1cccc(N2C(=O)[C@@H]3C(C(=O)C(c4ccccc4)c4ccccc4)=NN[C@H]3C2=O)c1.,COc1cccc(N2C(=O)[C@@H]3C(C(=O)C(c4ccccc4)c4ccccc4)=NN[C@H]3C2=O)c1,amine
+136675,Modify the molecule C[C@H](CCCO)NC(=O)Nc1cccc(Oc2ccncc2)c1 by removing a hydroxyl.,C[C@H](CCCO)NC(=O)Nc1cccc(Oc2ccncc2)c1,hydroxyl
+70978,Remove a hydroxyl from the molecule CCC(=O)Nc1ccc(Cl)c(NC(=O)CCCO)c1.,CCC(=O)Nc1ccc(Cl)c(NC(=O)CCCO)c1,hydroxyl
+21172,Please remove a halo from the molecule [NH3+][C@H](Cc1ccc(Cl)cc1)c1c(F)cc(Br)cc1F.,[NH3+][C@H](Cc1ccc(Cl)cc1)c1c(F)cc(Br)cc1F,halo
+137845,Remove a halo from the molecule CCc1cccnc1NC(=O)c1cnc2ccc(F)cc2c1.,CCc1cccnc1NC(=O)c1cnc2ccc(F)cc2c1,halo
+114605,Modify the molecule CCOC(=O)c1ccccc1NC(=O)[C@H]1C[C@@H]1c1ccccc1 by removing a benzene_ring.,CCOC(=O)c1ccccc1NC(=O)[C@H]1C[C@@H]1c1ccccc1,benzene_ring
+46766,Remove a amine from the molecule Nn1c(SCC(=O)N2CCCCC2)nnc1-c1ccc(F)cc1.,Nn1c(SCC(=O)N2CCCCC2)nnc1-c1ccc(F)cc1,amine
+247326,Remove a benzene_ring from the molecule COc1cccc(C(=O)[C@H]2CCCN(C(=O)c3cccc(C#CC(C)(C)O)c3)C2)c1.,COc1cccc(C(=O)[C@H]2CCCN(C(=O)c3cccc(C#CC(C)(C)O)c3)C2)c1,benzene_ring
+179923,Remove a benzene_ring from the molecule Cc1ccc([N+](=O)[O-])c(CCl)c1.,Cc1ccc([N+](=O)[O-])c(CCl)c1,benzene_ring
+174515,Remove a amide from the molecule O=C(/C=C/c1ccc(Cl)cc1)NC(=S)Nc1cc(C(=O)[O-])ccc1Cl.,O=C(/C=C/c1ccc(Cl)cc1)NC(=S)Nc1cc(C(=O)[O-])ccc1Cl,amide
+26967,Modify the molecule O=C(Cc1ccccc1)Nc1cccc(C(=O)Nc2ccccc2C(=O)[O-])c1 by removing a benzene_ring.,O=C(Cc1ccccc1)Nc1cccc(C(=O)Nc2ccccc2C(=O)[O-])c1,benzene_ring
+60293,Please remove a benzene_ring from the molecule Cc1ccc(S(=O)(=O)N2CC=CC2)cc1.,Cc1ccc(S(=O)(=O)N2CC=CC2)cc1,benzene_ring
+148725,Remove a amide from the molecule CC(C)CC1=C[C@@H](CN2CCN3NC(C(=O)NC4CC4)=C[C@@H]3C2)N=N1.,CC(C)CC1=C[C@@H](CN2CCN3NC(C(=O)NC4CC4)=C[C@@H]3C2)N=N1,amide
+220138,Modify the molecule CCn1nc(C)cc1CNc1ccn(C)n1 by removing a amine.,CCn1nc(C)cc1CNc1ccn(C)n1,amine
+33904,Please remove a benzene_ring from the molecule O=C(c1ccc(F)cc1F)N(CC(F)(F)F)c1ccccn1.,O=C(c1ccc(F)cc1F)N(CC(F)(F)F)c1ccccn1,benzene_ring
+119064,Please remove a amide from the molecule C=C(Nc1ccc(C(C)C)cc1)[C@H]1C(=O)NC(=O)N(CCCC)C1=O.,C=C(Nc1ccc(C(C)C)cc1)[C@H]1C(=O)NC(=O)N(CCCC)C1=O,amide
+108370,Modify the molecule CC(=O)c1c(C)[nH]c(C(=O)N2C[C@@H](C)Oc3ccc(C)cc32)c1C by removing a amide.,CC(=O)c1c(C)[nH]c(C(=O)N2C[C@@H](C)Oc3ccc(C)cc32)c1C,amide
+136564,Please remove a amine from the molecule CC[C@@H](C(=O)OCC(=O)c1c(N)n(C)c(=O)n(C)c1=O)c1ccccc1.,CC[C@@H](C(=O)OCC(=O)c1c(N)n(C)c(=O)n(C)c1=O)c1ccccc1,amine
+64591,Remove a benzene_ring from the molecule CCn1cc(C[NH+]2CCCC[C@H]2c2nc(N(C)C)ncc2-c2ccc(F)cc2)c(C)n1.,CCn1cc(C[NH+]2CCCC[C@H]2c2nc(N(C)C)ncc2-c2ccc(F)cc2)c(C)n1,benzene_ring
+141605,Remove a benzene_ring from the molecule Cc1ccc(NC(=O)CC[NH2+][C@@H]2CCN(C3CC3)C2)c(Cl)c1.,Cc1ccc(NC(=O)CC[NH2+][C@@H]2CCN(C3CC3)C2)c(Cl)c1,benzene_ring
+161414,Modify the molecule CCNC(=O)c1ccc(CNC(=O)c2oc3c(Cl)cccc3c2C)cc1 by removing a amide.,CCNC(=O)c1ccc(CNC(=O)c2oc3c(Cl)cccc3c2C)cc1,amide
+53853,Modify the molecule CC(C)Oc1ccc(NC(=O)C(=O)N[C@H](C)c2cccc(Cl)c2)cc1 by removing a amide.,CC(C)Oc1ccc(NC(=O)C(=O)N[C@H](C)c2cccc(Cl)c2)cc1,amide
+53154,Please remove a amide from the molecule Cc1cc(NC(=O)[C@@H]2C[C@@H]3C=C[C@H]2C3)ncc1Br.,Cc1cc(NC(=O)[C@@H]2C[C@@H]3C=C[C@H]2C3)ncc1Br,amide
+197434,Modify the molecule COC(OC)C12c3ccccc3C(c3ccccc31)[C@H]1C(=O)N(c3cccc(C(F)(F)F)c3)C(=O)[C@@H]12 by removing a halo.,COC(OC)C12c3ccccc3C(c3ccccc31)[C@H]1C(=O)N(c3cccc(C(F)(F)F)c3)C(=O)[C@@H]12,halo
+103210,Remove a benzene_ring from the molecule Cc1nn2ncc(C(=O)NCCc3ccc(OCc4ccccc4)cc3)c2[nH]1.,Cc1nn2ncc(C(=O)NCCc3ccc(OCc4ccccc4)cc3)c2[nH]1,benzene_ring
+120170,Remove a benzene_ring from the molecule c1ccc(Cn2nnnc2[C@@H](c2ccccc2)N2CC[NH+](Cc3ccncc3)CC2)cc1.,c1ccc(Cn2nnnc2[C@@H](c2ccccc2)N2CC[NH+](Cc3ccncc3)CC2)cc1,benzene_ring
+27690,Remove a nitro from the molecule O=[N+]([O-])c1ccc(-c2cc[nH]n2)cc1CS(=O)(=O)c1ccccc1.,O=[N+]([O-])c1ccc(-c2cc[nH]n2)cc1CS(=O)(=O)c1ccccc1,nitro
+63128,Modify the molecule COc1ccccc1[C@@H]1CN(C(=O)c2cccs2)C[C@H]1C(=O)N1CCOCC1 by removing a benzene_ring.,COc1ccccc1[C@@H]1CN(C(=O)c2cccs2)C[C@H]1C(=O)N1CCOCC1,benzene_ring
+177815,Modify the molecule CCC(=O)N1CCN(C(=O)NCc2cn3c(C)cccc3[nH+]2)CC1 by removing a amide.,CCC(=O)N1CCN(C(=O)NCc2cn3c(C)cccc3[nH+]2)CC1,amide
+237916,Remove a benzene_ring from the molecule CCOC(=O)[C@H](C)Sc1ccc(N)c(C)c1.,CCOC(=O)[C@H](C)Sc1ccc(N)c(C)c1,benzene_ring
+197840,Modify the molecule COc1cccc2c(C)c(C(=O)N[C@@H]3c4ccccc4C[C@@H]3O)oc12 by removing a amide.,COc1cccc2c(C)c(C(=O)N[C@@H]3c4ccccc4C[C@@H]3O)oc12,amide
+116688,Remove a benzene_ring from the molecule CCC[C@H](NC(=O)Nc1cnn(CC(N)=O)c1)c1ccccc1.,CCC[C@H](NC(=O)Nc1cnn(CC(N)=O)c1)c1ccccc1,benzene_ring
+241653,Modify the molecule NC(=S)c1c(F)cccc1-n1cnc2ccccc21 by removing a amine.,NC(=S)c1c(F)cccc1-n1cnc2ccccc21,amine
+218284,Modify the molecule CCOc1ccccc1-c1cccc(C(=O)N(C)C[C@@H]2CC[NH+](C)C2)c1 by removing a amide.,CCOc1ccccc1-c1cccc(C(=O)N(C)C[C@@H]2CC[NH+](C)C2)c1,amide
+230672,Remove a benzene_ring from the molecule CCc1nsc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)n1.,CCc1nsc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)n1,benzene_ring
+146966,Remove a benzene_ring from the molecule COc1ccc(NS(=O)(=O)c2cccc3nonc23)cc1Cl.,COc1ccc(NS(=O)(=O)c2cccc3nonc23)cc1Cl,benzene_ring
+35644,Modify the molecule Cc1ocnc1CNC(=O)N[C@@H]1CCCN(c2ccccc2F)C1 by removing a benzene_ring.,Cc1ocnc1CNC(=O)N[C@@H]1CCCN(c2ccccc2F)C1,benzene_ring
+168579,Please remove a benzene_ring from the molecule COc1cccc(CNC(=O)COC(=O)c2ccc(C)c(C)c2)c1.,COc1cccc(CNC(=O)COC(=O)c2ccc(C)c(C)c2)c1,benzene_ring
+157206,Remove a benzene_ring from the molecule CCCC[C@H]([NH2+]C)c1ccc(OC)cc1.,CCCC[C@H]([NH2+]C)c1ccc(OC)cc1,benzene_ring
+205425,Please remove a amide from the molecule O=C(NCc1cccnc1-n1cccn1)[C@@H]1CCCN(C(=O)c2ccco2)C1.,O=C(NCc1cccnc1-n1cccn1)[C@@H]1CCCN(C(=O)c2ccco2)C1,amide
+107400,Please remove a benzene_ring from the molecule O=C(C[NH2+]C[C@@H]1COc2ccccc2O1)Nc1ccccc1.,O=C(C[NH2+]C[C@@H]1COc2ccccc2O1)Nc1ccccc1,benzene_ring
+73383,Modify the molecule CC[C@](C)([C@@H](NC)c1cccc(F)c1F)[NH+]1CCCCC1 by removing a benzene_ring.,CC[C@](C)([C@@H](NC)c1cccc(F)c1F)[NH+]1CCCCC1,benzene_ring
+181051,Remove a amide from the molecule Cc1cscc1C[NH2+]CC(=O)NC1CCCCCC1.,Cc1cscc1C[NH2+]CC(=O)NC1CCCCCC1,amide
+21631,Modify the molecule Cc1cccn2c(=O)c(C(=O)N[C@@H](C)C(C)(C)C[NH+](C)C)cnc12 by removing a amide.,Cc1cccn2c(=O)c(C(=O)N[C@@H](C)C(C)(C)C[NH+](C)C)cnc12,amide
+103291,Remove a amide from the molecule Cc1cc(C)cc(NC(=O)CNc2ccc(C(=O)NC(C)(C)C)cc2)c1.,Cc1cc(C)cc(NC(=O)CNc2ccc(C(=O)NC(C)(C)C)cc2)c1,amide
+225789,Modify the molecule C[C@H]([NH2+]Cc1cnn(C(C)(C)C)c1)c1ccc2c(c1)NC(=O)CO2 by removing a amide.,C[C@H]([NH2+]Cc1cnn(C(C)(C)C)c1)c1ccc2c(c1)NC(=O)CO2,amide
+11293,Modify the molecule CSCc1ccc(C(=O)N[C@H]2CCCc3ccccc32)cc1 by removing a amide.,CSCc1ccc(C(=O)N[C@H]2CCCc3ccccc32)cc1,amide
+218999,Remove a benzene_ring from the molecule CCO[C@H](C)C(=O)Nc1ccccc1OCC1CC1.,CCO[C@H](C)C(=O)Nc1ccccc1OCC1CC1,benzene_ring
+13032,Remove a benzene_ring from the molecule Cn1c(=O)c2c(nc(Cl)n2CC(=O)Nc2ccccc2OC(F)F)n(C)c1=O.,Cn1c(=O)c2c(nc(Cl)n2CC(=O)Nc2ccccc2OC(F)F)n(C)c1=O,benzene_ring
+21592,Please remove a amide from the molecule CC(C)(C)c1ccc(C2(C(=O)OC[C@@H]3CCC(=O)N3)CC2)cc1.,CC(C)(C)c1ccc(C2(C(=O)OC[C@@H]3CCC(=O)N3)CC2)cc1,amide
+216097,Please remove a benzene_ring from the molecule CC[C@@](C)([C@@H](N)c1c(F)cccc1F)[NH+](C)C.,CC[C@@](C)([C@@H](N)c1c(F)cccc1F)[NH+](C)C,benzene_ring
+104911,Remove a benzene_ring from the molecule C/[NH+]=C(/NCc1ccnc(-n2ccnc2)c1)NCc1ccccc1Cl.,C/[NH+]=C(/NCc1ccnc(-n2ccnc2)c1)NCc1ccccc1Cl,benzene_ring
+81236,Please remove a halo from the molecule C#CCOc1ccc(F)cc1NC(=O)[C@@H](C)Sc1ccccn1.,C#CCOc1ccc(F)cc1NC(=O)[C@@H](C)Sc1ccccn1,halo
+181137,Remove a amide from the molecule COc1ccc([C@@H]2C[C@H](C(F)(F)F)n3nc(C(=O)Nc4ccc(Cl)cc4)cc3N2)cc1.,COc1ccc([C@@H]2C[C@H](C(F)(F)F)n3nc(C(=O)Nc4ccc(Cl)cc4)cc3N2)cc1,amide
+103321,Remove a benzene_ring from the molecule CC(=O)C1=C([O-])C(=O)N(Cc2cccnc2)[C@@H]1c1ccc(C(C)C)cc1.,CC(=O)C1=C([O-])C(=O)N(Cc2cccnc2)[C@@H]1c1ccc(C(C)C)cc1,benzene_ring
+15808,Please remove a benzene_ring from the molecule CC[C@H](NS(=O)(=O)c1ccccc1)c1nccs1.,CC[C@H](NS(=O)(=O)c1ccccc1)c1nccs1,benzene_ring
+206036,Modify the molecule O=C1C[C@@H](c2ccco2)Cc2c1cnn2-c1ccccc1F by removing a benzene_ring.,O=C1C[C@@H](c2ccco2)Cc2c1cnn2-c1ccccc1F,benzene_ring
+59983,Remove a benzene_ring from the molecule Cc1cc(C)cc(C(=O)NCCn2nc(-c3ccncc3)ccc2=O)c1.,Cc1cc(C)cc(C(=O)NCCn2nc(-c3ccncc3)ccc2=O)c1,benzene_ring
+141538,Remove a amide from the molecule CN(CCC1CC1)C(=O)c1ccc(C(=O)OC(C)(C)C)cc1.,CN(CCC1CC1)C(=O)c1ccc(C(=O)OC(C)(C)C)cc1,amide
+87363,Remove a benzene_ring from the molecule CC[C@H](O)[C@@H](C)c1ccc(C(C)C)cc1.,CC[C@H](O)[C@@H](C)c1ccc(C(C)C)cc1,benzene_ring
+16486,Remove a amide from the molecule COc1ccc(CNC(=O)Cc2c(C)c3ccc(O)c(O)c3oc2=O)cc1.,COc1ccc(CNC(=O)Cc2c(C)c3ccc(O)c(O)c3oc2=O)cc1,amide
+223928,Please remove a amide from the molecule O=C(c1ccccc1)[C@H]1[C@@H]2C(=O)N(c3ccc(Br)cc3)C(=O)[C@@H]2[C@H]2C=CC=CN21.,O=C(c1ccccc1)[C@H]1[C@@H]2C(=O)N(c3ccc(Br)cc3)C(=O)[C@@H]2[C@H]2C=CC=CN21,amide
+83173,Modify the molecule Cc1nc2ccc(N[C@@H](C)C[C@H]3CCC[NH2+]3)cc2s1 by removing a amine.,Cc1nc2ccc(N[C@@H](C)C[C@H]3CCC[NH2+]3)cc2s1,amine
+87777,Modify the molecule CCOC(=O)Cn1c([C@H]2CC(=O)N(Cc3ccccc3)C2)nc2ccccc21 by removing a amide.,CCOC(=O)Cn1c([C@H]2CC(=O)N(Cc3ccccc3)C2)nc2ccccc21,amide
+227752,Please remove a benzene_ring from the molecule CCn1c(SCC(=O)NN)nnc1-c1ccc(C(C)(C)C)cc1.,CCn1c(SCC(=O)NN)nnc1-c1ccc(C(C)(C)C)cc1,benzene_ring
+127437,Remove a amine from the molecule C[C@@H]1C[NH+]=C(N2CCN(Cc3cnnn3C)CC2)S1.,C[C@@H]1C[NH+]=C(N2CCN(Cc3cnnn3C)CC2)S1,amine
+181697,Remove a amide from the molecule COc1cccc2cc(C(=O)Nc3ccc4c(c3)C(=O)NCC4)c(=O)oc12.,COc1cccc2cc(C(=O)Nc3ccc4c(c3)C(=O)NCC4)c(=O)oc12,amide
+98010,Remove a benzene_ring from the molecule C[NH+]1CCC[C@@H](c2cnc(-c3ccccc3Cl)cn2)C1.,C[NH+]1CCC[C@@H](c2cnc(-c3ccccc3Cl)cn2)C1,benzene_ring
+2124,Remove a halo from the molecule Cc1cc(C)n(CC(=O)Nc2ccc(F)c(Cl)c2)c(=O)c1-c1nc(-c2ccc3c(c2)OCO3)no1.,Cc1cc(C)n(CC(=O)Nc2ccc(F)c(Cl)c2)c(=O)c1-c1nc(-c2ccc3c(c2)OCO3)no1,halo
+154725,Please remove a amide from the molecule CC1(C)C(=O)NC(=O)N1CC(=O)N[C@H]1CCC[C@@H]1Cc1ccccc1.,CC1(C)C(=O)NC(=O)N1CC(=O)N[C@H]1CCC[C@@H]1Cc1ccccc1,amide
+156770,Modify the molecule Cc1ccc2nc(SCC(=O)NCCCN3C[C@H](C)O[C@H](C)C3)[nH]c2c1 by removing a amide.,Cc1ccc2nc(SCC(=O)NCCCN3C[C@H](C)O[C@H](C)C3)[nH]c2c1,amide
+210047,Please remove a benzene_ring from the molecule CC[C@@H]1CC[C@](C#N)([C@H](O)c2ccc(Br)cc2)C1.,CC[C@@H]1CC[C@](C#N)([C@H](O)c2ccc(Br)cc2)C1,benzene_ring
+180748,Modify the molecule COc1ccc2oc(C(=O)NCCc3ccc(F)cc3)c(C)c2c1 by removing a amide.,COc1ccc2oc(C(=O)NCCc3ccc(F)cc3)c(C)c2c1,amide
+136362,Please remove a benzene_ring from the molecule CCc1cccc(OCC(=O)Nc2nc(-c3ccccc3)c(C(C)=O)s2)c1.,CCc1cccc(OCC(=O)Nc2nc(-c3ccccc3)c(C(C)=O)s2)c1,benzene_ring
+204271,Please remove a benzene_ring from the molecule O=C(NCCOCC(F)(F)F)N[C@@H]1C[C@H]1c1cccc(Cl)c1.,O=C(NCCOCC(F)(F)F)N[C@@H]1C[C@H]1c1cccc(Cl)c1,benzene_ring
+217520,Please remove a halo from the molecule Cc1cc(S(=O)(=O)N(C)C)c(C)cc1Br.,Cc1cc(S(=O)(=O)N(C)C)c(C)cc1Br,halo
+187372,Please remove a benzene_ring from the molecule CSc1cc(C(=O)O[C@@H](C)C(=O)Nc2c(F)cccc2F)ccc1N.,CSc1cc(C(=O)O[C@@H](C)C(=O)Nc2c(F)cccc2F)ccc1N,benzene_ring
+87024,Remove a benzene_ring from the molecule Cc1noc(C)c1NC(=O)N1CCN(Cc2ccccc2)C(C)(C)C1.,Cc1noc(C)c1NC(=O)N1CCN(Cc2ccccc2)C(C)(C)C1,benzene_ring
+96288,Remove a benzene_ring from the molecule COc1ccc(-c2nc3n(n2)[C@H](CC(=O)Nc2cccc4ccccc24)C(=O)N3)cc1.,COc1ccc(-c2nc3n(n2)[C@H](CC(=O)Nc2cccc4ccccc24)C(=O)N3)cc1,benzene_ring
+112659,Please remove a nitro from the molecule CCc1c([N+](=O)[O-])cc(C(=O)[O-])n1C.,CCc1c([N+](=O)[O-])cc(C(=O)[O-])n1C,nitro
+170825,Remove a amide from the molecule CCCCN1CCN(C(=O)c2ccc(-c3ccsc3)nc2)CC1.,CCCCN1CCN(C(=O)c2ccc(-c3ccsc3)nc2)CC1,amide
+214835,Remove a hydroxyl from the molecule COC(=O)c1ccc(/C=C(/C)CO)o1.,COC(=O)c1ccc(/C=C(/C)CO)o1,hydroxyl
+54079,Please remove a halo from the molecule O=C(Nc1ncc(Cc2ccc(OC(F)(F)F)cc2)s1)c1cccnc1.,O=C(Nc1ncc(Cc2ccc(OC(F)(F)F)cc2)s1)c1cccnc1,halo
+235345,Remove a nitrile from the molecule CN1C(=O)N[C@](C)([C@H]2CCC[NH+](Cc3cccc(C#N)c3)C2)C1=O.,CN1C(=O)N[C@](C)([C@H]2CCC[NH+](Cc3cccc(C#N)c3)C2)C1=O,nitrile
+160409,Remove a amide from the molecule Cc1ccc(S(=O)(=O)N2CCCC[C@H]2CCNC(=O)c2snnc2C)cc1.,Cc1ccc(S(=O)(=O)N2CCCC[C@H]2CCNC(=O)c2snnc2C)cc1,amide
+238083,Modify the molecule Cc1cc(C)cc([C@@H](O)C2(C#N)CCCCC2)c1 by removing a hydroxyl.,Cc1cc(C)cc([C@@H](O)C2(C#N)CCCCC2)c1,hydroxyl
+87879,Remove a benzene_ring from the molecule Cc1ccc([C@@H](NC(=O)Cc2n[nH]c(=O)c3ccccc23)C2CC2)cc1.,Cc1ccc([C@@H](NC(=O)Cc2n[nH]c(=O)c3ccccc23)C2CC2)cc1,benzene_ring
+166892,Please remove a nitro from the molecule C#CC[C@H](OC(=O)Cn1cnc([N+](=O)[O-])n1)c1ccccn1.,C#CC[C@H](OC(=O)Cn1cnc([N+](=O)[O-])n1)c1ccccn1,nitro
+247847,Modify the molecule CCc1ccc(NC(=O)C(=O)NCC[NH+]2CCN(c3ccccc3)CC2)cc1 by removing a amide.,CCc1ccc(NC(=O)C(=O)NCC[NH+]2CCN(c3ccccc3)CC2)cc1,amide
+108699,Remove a amide from the molecule O=C(CCn1nnc2ccccc21)N1CCC[C@H]1c1nc2ccccc2[nH]1.,O=C(CCn1nnc2ccccc21)N1CCC[C@H]1c1nc2ccccc2[nH]1,amide
+120363,Modify the molecule COc1cccc(C[NH2+][C@H](C)c2ccc(C#N)cc2)c1OC by removing a benzene_ring.,COc1cccc(C[NH2+][C@H](C)c2ccc(C#N)cc2)c1OC,benzene_ring
+234264,Modify the molecule Cc1ccccc1-c1ccc(Cl)c(O)c1 by removing a benzene_ring.,Cc1ccccc1-c1ccc(Cl)c(O)c1,benzene_ring
+136714,Please remove a amine from the molecule CCn1nc(C)c(-c2ccnc(NCc3cnn(Cc4ccccc4)c3)n2)c1C.,CCn1nc(C)c(-c2ccnc(NCc3cnn(Cc4ccccc4)c3)n2)c1C,amine
+245873,Modify the molecule O=C(NCC1(c2ccccc2)CCCCCC1)NNC(=O)[C@H]1CCCO1 by removing a benzene_ring.,O=C(NCC1(c2ccccc2)CCCCCC1)NNC(=O)[C@H]1CCCO1,benzene_ring
+171540,Modify the molecule Cc1ccc(CC(=O)c2cc(F)c(C)cc2F)cc1 by removing a halo.,Cc1ccc(CC(=O)c2cc(F)c(C)cc2F)cc1,halo
+233646,Please remove a amide from the molecule O=C(Cc1cc(Cl)c2c(c1)OCCO2)Nc1ccncc1.,O=C(Cc1cc(Cl)c2c(c1)OCCO2)Nc1ccncc1,amide
+133471,Remove a amide from the molecule CSCC[C@H](NC(=O)c1cc(Cl)nc(Cl)c1)c1nnc2ccccn12.,CSCC[C@H](NC(=O)c1cc(Cl)nc(Cl)c1)c1nnc2ccccn12,amide
+158441,Remove a amide from the molecule Cc1n[nH]c2ncc(C(=O)NC[C@@H]3COc4ccccc4O3)cc12.,Cc1n[nH]c2ncc(C(=O)NC[C@@H]3COc4ccccc4O3)cc12,amide
+35828,Modify the molecule O=C(N[C@H]1CCCc2ccccc21)c1ccc([N+](=O)[O-])s1 by removing a amide.,O=C(N[C@H]1CCCc2ccccc21)c1ccc([N+](=O)[O-])s1,amide
+166624,Remove a amine from the molecule C=CCNc1nc(N2CCCCC2)nc(N2CCCCC2)n1.,C=CCNc1nc(N2CCCCC2)nc(N2CCCCC2)n1,amine
+201469,Modify the molecule Cc1ccccc1-c1nc(C(=O)Nc2cccc(C)c2C(N)=O)cs1 by removing a amide.,Cc1ccccc1-c1nc(C(=O)Nc2cccc(C)c2C(N)=O)cs1,amide
+118760,Please remove a amide from the molecule COc1ccc(NC(=O)CC[NH+]2CCC(NC(=O)C3CC3)CC2)cc1.,COc1ccc(NC(=O)CC[NH+]2CCC(NC(=O)C3CC3)CC2)cc1,amide
+123100,Modify the molecule O=C(NC1CCC(O)CC1)[C@@H]1C[C@@H]1c1cccc(Br)c1 by removing a hydroxyl.,O=C(NC1CCC(O)CC1)[C@@H]1C[C@@H]1c1cccc(Br)c1,hydroxyl
+244402,Modify the molecule CCc1nc2c(s1)[C@H]([NH2+]CCOc1ccc(Cl)cn1)CCC2 by removing a halo.,CCc1nc2c(s1)[C@H]([NH2+]CCOc1ccc(Cl)cn1)CCC2,halo
+6059,Modify the molecule O=C(NCCc1ccccc1Cl)N[C@H](CO)c1ccco1 by removing a halo.,O=C(NCCc1ccccc1Cl)N[C@H](CO)c1ccco1,halo
+172657,Remove a amide from the molecule Cn1cc([C@H]2C[C@@H]2C(=O)OCC(=O)NC2CCCCC2)cn1.,Cn1cc([C@H]2C[C@@H]2C(=O)OCC(=O)NC2CCCCC2)cn1,amide
+63310,Remove a amide from the molecule C=CCN(Cc1cccs1)C(=O)N[C@@H](C)C(=O)N1CCCCC1.,C=CCN(Cc1cccs1)C(=O)N[C@@H](C)C(=O)N1CCCCC1,amide
+122381,Please remove a hydroxyl from the molecule COc1cc([C@@H](C)[NH2+]C[C@@]2(O)CCOC2)ccc1F.,COc1cc([C@@H](C)[NH2+]C[C@@]2(O)CCOC2)ccc1F,hydroxyl
+99489,Remove a amide from the molecule Cc1ccc(N2C[C@H](C(=O)N3CCN(c4nccn4-c4cccc(Cl)c4)CC3)CC2=O)cc1C.,Cc1ccc(N2C[C@H](C(=O)N3CCN(c4nccn4-c4cccc(Cl)c4)CC3)CC2=O)cc1C,amide
+227736,Modify the molecule O=C(Nc1ccccn1)[C@H]1CCCN1C(=O)c1ccc(Cl)c(Cl)c1 by removing a halo.,O=C(Nc1ccccn1)[C@H]1CCCN1C(=O)c1ccc(Cl)c(Cl)c1,halo
+182068,Modify the molecule CCOc1ccc(NC(=S)N2C[C@@H](C)O[C@H](C)C2)cc1 by removing a benzene_ring.,CCOc1ccc(NC(=S)N2C[C@@H](C)O[C@H](C)C2)cc1,benzene_ring
+228480,Remove a halo from the molecule Cc1ccc(NC(=O)Cc2csc(-c3cnccn3)n2)cc1C(F)(F)F.,Cc1ccc(NC(=O)Cc2csc(-c3cnccn3)n2)cc1C(F)(F)F,halo
+208916,Modify the molecule C[C@H](Cc1ccccc1)NC(=O)c1ccc(Br)nc1 by removing a amide.,C[C@H](Cc1ccccc1)NC(=O)c1ccc(Br)nc1,amide
+129962,Remove a amide from the molecule CC(=O)N1CCN(C(=O)C[NH+]2CCCC[C@H]2Cn2cncn2)CC1.,CC(=O)N1CCN(C(=O)C[NH+]2CCCC[C@H]2Cn2cncn2)CC1,amide
+204798,Remove a benzene_ring from the molecule Cc1ccc(S(=O)(=O)N(C)c2ccc(OC(=O)c3ccccn3)cc2)cc1C.,Cc1ccc(S(=O)(=O)N(C)c2ccc(OC(=O)c3ccccn3)cc2)cc1C,benzene_ring
+216396,Remove a amine from the molecule CC(C)(C)c1cccc(NN)c1.,CC(C)(C)c1cccc(NN)c1,amine
+216900,Remove a amide from the molecule C[C@H]1CCC[C@H](C)N1C(=O)[C@@H](C)[NH+]1CCN(CC(=O)N2CCCC2)CC1.,C[C@H]1CCC[C@H](C)N1C(=O)[C@@H](C)[NH+]1CCN(CC(=O)N2CCCC2)CC1,amide
+109952,Remove a benzene_ring from the molecule COC(=O)/C(=C/c1cccc([N+](=O)[O-])c1)Cn1cncn1.,COC(=O)/C(=C/c1cccc([N+](=O)[O-])c1)Cn1cncn1,benzene_ring
+33083,Modify the molecule O=C(N[C@@H]1CCCc2c1cnn2-c1ccccc1F)c1ccc(N2CCOCC2)cc1 by removing a benzene_ring.,O=C(N[C@@H]1CCCc2c1cnn2-c1ccccc1F)c1ccc(N2CCOCC2)cc1,benzene_ring
+58359,Please remove a benzene_ring from the molecule COc1ccc(Br)c(COc2ccc(CC[NH3+])nc2)c1.,COc1ccc(Br)c(COc2ccc(CC[NH3+])nc2)c1,benzene_ring
+68005,Remove a benzene_ring from the molecule CC[C@@H](c1ccccc1)[C@@H]1CCCN1C(=O)CSc1nnnn1C.,CC[C@@H](c1ccccc1)[C@@H]1CCCN1C(=O)CSc1nnnn1C,benzene_ring
+211355,Modify the molecule COc1ccc(Cl)c2c1N[C@@H](c1ccc(C(=O)[O-])cc1)[C@@H]1CC=C[C@H]21 by removing a amine.,COc1ccc(Cl)c2c1N[C@@H](c1ccc(C(=O)[O-])cc1)[C@@H]1CC=C[C@H]21,amine
+131680,Please remove a benzene_ring from the molecule COC(=O)C1[C@@H](c2ccccc2)C(C(=O)[O-])[C@@H]1c1ccccc1.,COC(=O)C1[C@@H](c2ccccc2)C(C(=O)[O-])[C@@H]1c1ccccc1,benzene_ring
+246587,Remove a halo from the molecule O=C(Oc1ccc2cc(-c3ccc(Cl)cc3)c(=O)oc2c1)[C@@H]1CCCO1.,O=C(Oc1ccc2cc(-c3ccc(Cl)cc3)c(=O)oc2c1)[C@@H]1CCCO1,halo
+204463,Please remove a amide from the molecule CC[NH+]1CCC[C@@H]1CN1C[C@H](C(=O)NCc2ccc(C(N)=O)o2)CC1=O.,CC[NH+]1CCC[C@@H]1CN1C[C@H](C(=O)NCc2ccc(C(N)=O)o2)CC1=O,amide
+90694,Modify the molecule Cc1nc(C)n([C@@H]2CCCN(C(=O)CC[C@H]3CCCO3)C2)n1 by removing a amide.,Cc1nc(C)n([C@@H]2CCCN(C(=O)CC[C@H]3CCCO3)C2)n1,amide
+192910,Modify the molecule COc1ccc(NC(=S)N[C@H](NC(=O)N2CCOCC2)C(Cl)(Cl)Cl)cc1 by removing a halo.,COc1ccc(NC(=S)N[C@H](NC(=O)N2CCOCC2)C(Cl)(Cl)Cl)cc1,halo
+81615,Please remove a benzene_ring from the molecule CC(=O)Nc1ccc(NS(=O)(=O)c2ccc3oc(=O)ccc3c2)cc1.,CC(=O)Nc1ccc(NS(=O)(=O)c2ccc3oc(=O)ccc3c2)cc1,benzene_ring
+155666,Please remove a amide from the molecule Cc1cc(C)c(/C=N/NC(=O)COc2ccc([N+](=O)[O-])cc2)c(C)c1.,Cc1cc(C)c(/C=N/NC(=O)COc2ccc([N+](=O)[O-])cc2)c(C)c1,amide
+245364,Please remove a halo from the molecule Cc1[nH]ncc1CCCNC(=O)N[C@H](C)c1ccc(Br)cc1.,Cc1[nH]ncc1CCCNC(=O)N[C@H](C)c1ccc(Br)cc1,halo
+61045,Please remove a halo from the molecule COc1ccc2c(c1)C(N1CCN(C(=O)c3ccccc3F)[C@@H](C)C1)=Nc1ccccc1O2.,COc1ccc2c(c1)C(N1CCN(C(=O)c3ccccc3F)[C@@H](C)C1)=Nc1ccccc1O2,halo
+232373,Modify the molecule COc1cccc(CO[C@H](C)C(=O)N[C@H]2C[C@@H](C)N(c3ccccc3)C2)c1 by removing a amide.,COc1cccc(CO[C@H](C)C(=O)N[C@H]2C[C@@H](C)N(c3ccccc3)C2)c1,amide
+120867,Remove a amide from the molecule CC(C)N(Cc1cnn(C)c1)C(=O)[C@H]1CCC(=O)N(CCN2CCOCC2)C1.,CC(C)N(Cc1cnn(C)c1)C(=O)[C@H]1CCC(=O)N(CCN2CCOCC2)C1,amide
+217716,Please remove a amide from the molecule CO[C@@H]1CCCC[C@H]1NC(=O)/C=C/c1cnc(C(C)(C)C)s1.,CO[C@@H]1CCCC[C@H]1NC(=O)/C=C/c1cnc(C(C)(C)C)s1,amide
+214353,Modify the molecule CCNC(=O)C1CC[NH+](CC(=O)N[C@H](c2ccccc2)C2CC2)CC1 by removing a amide.,CCNC(=O)C1CC[NH+](CC(=O)N[C@H](c2ccccc2)C2CC2)CC1,amide
+144889,Please remove a benzene_ring from the molecule CCOC(=O)c1cccc(N[C@H]2CSCC(C)(C)C2)c1.,CCOC(=O)c1cccc(N[C@H]2CSCC(C)(C)C2)c1,benzene_ring
+214038,Please remove a halo from the molecule Clc1ccnc(CSc2nnc3n2CCCCC3)c1.,Clc1ccnc(CSc2nnc3n2CCCCC3)c1,halo
+39227,Remove a benzene_ring from the molecule Cc1cc(C)c(C[S@](=O)[C@H](C)c2nc(-c3ccccc3)no2)c(C)c1.,Cc1cc(C)c(C[S@](=O)[C@H](C)c2nc(-c3ccccc3)no2)c(C)c1,benzene_ring
+143467,Remove a halo from the molecule Cc1nn(C)cc1[C@@H](C)NC(=O)c1csc(-c2ccc(Cl)cc2)n1.,Cc1nn(C)cc1[C@@H](C)NC(=O)c1csc(-c2ccc(Cl)cc2)n1,halo
+20921,Remove a amide from the molecule CCc1cc(C(=O)N[C@@H]2CCCC[C@@H]2C[NH+](C)C)n(C)n1.,CCc1cc(C(=O)N[C@@H]2CCCC[C@@H]2C[NH+](C)C)n(C)n1,amide
+203216,Remove a benzene_ring from the molecule O=C(NC[C@@H]1COc2ccccc2O1)[C@H]1CCCN1C(=O)OCc1ccccc1.,O=C(NC[C@@H]1COc2ccccc2O1)[C@H]1CCCN1C(=O)OCc1ccccc1,benzene_ring
+175496,Modify the molecule CC[C@@H]1CCCCN1C(=O)C[C@@H]1C=CCC1 by removing a amide.,CC[C@@H]1CCCCN1C(=O)C[C@@H]1C=CCC1,amide
+94285,Remove a benzene_ring from the molecule Clc1ccccc1-c1nc(Cn2nccc2-c2ccncc2)no1.,Clc1ccccc1-c1nc(Cn2nccc2-c2ccncc2)no1,benzene_ring
+10540,Please remove a hydroxyl from the molecule C=C(C)C[C@@H](O)[C@]1([NH+](C)C)CCC[C@@H](C)C1.,C=C(C)C[C@@H](O)[C@]1([NH+](C)C)CCC[C@@H](C)C1,hydroxyl
+129696,Modify the molecule CCOc1ccc(CC(=O)Nc2sc3c(c2C#N)CCCCC3)cc1 by removing a benzene_ring.,CCOc1ccc(CC(=O)Nc2sc3c(c2C#N)CCCCC3)cc1,benzene_ring
+192987,Modify the molecule Cc1cc(C)c(C#N)c(SCC(=O)Nc2ccccc2SCC#N)n1 by removing a amide.,Cc1cc(C)c(C#N)c(SCC(=O)Nc2ccccc2SCC#N)n1,amide
+97812,Modify the molecule Cc1ncn(C[C@@H](C)[NH2+]CC(C)(C)c2ccccc2Cl)c1C by removing a halo.,Cc1ncn(C[C@@H](C)[NH2+]CC(C)(C)c2ccccc2Cl)c1C,halo
+165186,Remove a benzene_ring from the molecule Cc1cc(C)c(S(=O)(=O)N(Cc2ccco2)Cc2cc3cccc(C)c3[nH]c2=O)c(C)c1.,Cc1cc(C)c(S(=O)(=O)N(Cc2ccco2)Cc2cc3cccc(C)c3[nH]c2=O)c(C)c1,benzene_ring
+117958,Remove a benzene_ring from the molecule CNS(=O)(=O)Cc1ccccc1CNC(=O)c1c(-c2ccccc2)noc1C.,CNS(=O)(=O)Cc1ccccc1CNC(=O)c1c(-c2ccccc2)noc1C,benzene_ring
+6629,Please remove a amine from the molecule CCCNc1ncc(C[NH+]2C[C@H](C)C[C@@H](C)C2)s1.,CCCNc1ncc(C[NH+]2C[C@H](C)C[C@@H](C)C2)s1,amine
+224089,Remove a amide from the molecule C[C@H](C(=O)N1CCCCC1)N(c1ccc(Oc2ccccc2)cc1)S(C)(=O)=O.,C[C@H](C(=O)N1CCCCC1)N(c1ccc(Oc2ccccc2)cc1)S(C)(=O)=O,amide
+70286,Modify the molecule C[C@@H](NC(=O)c1ccoc1)C(=O)N[C@H](C)c1noc(Cc2ccccc2)n1 by removing a amide.,C[C@@H](NC(=O)c1ccoc1)C(=O)N[C@H](C)c1noc(Cc2ccccc2)n1,amide
+187080,Please remove a benzene_ring from the molecule O=C(C[C@H]1CCS(=O)(=O)C1)OCc1nccn1Cc1ccccc1.,O=C(C[C@H]1CCS(=O)(=O)C1)OCc1nccn1Cc1ccccc1,benzene_ring
+88142,Modify the molecule COC(=O)c1c(S(=O)(=O)Nc2ccc(C)c(F)c2)sc2c1CCN(C(=O)c1csnn1)C2 by removing a amide.,COC(=O)c1c(S(=O)(=O)Nc2ccc(C)c(F)c2)sc2c1CCN(C(=O)c1csnn1)C2,amide
+234892,Remove a thiol from the molecule OC[C@@H]1CCCC[NH+]1CCS.,OC[C@@H]1CCCC[NH+]1CCS,thiol
+25481,Modify the molecule COC(=O)c1ccc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)cc1 by removing a benzene_ring.,COC(=O)c1ccc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)cc1,benzene_ring
+225583,Modify the molecule [O-]c1nc(N2CCc3ccccc3C2)nc2ncn(-c3ccc(Cl)c(Cl)c3)c(=S)c12 by removing a benzene_ring.,[O-]c1nc(N2CCc3ccccc3C2)nc2ncn(-c3ccc(Cl)c(Cl)c3)c(=S)c12,benzene_ring
+67389,Remove a nitrile from the molecule CC(C)c1nc(C[S@](=O)CCCCC#N)cs1.,CC(C)c1nc(C[S@](=O)CCCCC#N)cs1,nitrile
+244994,Remove a benzene_ring from the molecule Cc1ccc(C)c(CC(=O)c2ccc(F)c(F)c2F)c1.,Cc1ccc(C)c(CC(=O)c2ccc(F)c(F)c2F)c1,benzene_ring
+133265,Modify the molecule CC(C)c1ccc(NC(=O)C2=CN(C)[C@H]3C(=O)N(Cc4ccccc4)C(=O)N=C23)cc1 by removing a amide.,CC(C)c1ccc(NC(=O)C2=CN(C)[C@H]3C(=O)N(Cc4ccccc4)C(=O)N=C23)cc1,amide
+122626,Remove a benzene_ring from the molecule C[NH+](C)[C@H]1CC[C@@H](NC(=O)c2ccccc2CSc2nc3ccccc3[nH]2)C1.,C[NH+](C)[C@H]1CC[C@@H](NC(=O)c2ccccc2CSc2nc3ccccc3[nH]2)C1,benzene_ring
+40756,Remove a amide from the molecule Cc1ccccc1-c1cc(C(=O)NCC(C)(C)C[NH+](C)C)c2cnn(C(C)C)c2n1.,Cc1ccccc1-c1cc(C(=O)NCC(C)(C)C[NH+](C)C)c2cnn(C(C)C)c2n1,amide
+248645,Remove a benzene_ring from the molecule Cc1ccc(NC(=O)N(C)Cc2[nH+]ccn2C)cc1C.,Cc1ccc(NC(=O)N(C)Cc2[nH+]ccn2C)cc1C,benzene_ring
+228989,Modify the molecule CNC(=O)c1ccccc1NC(=O)C[C@H](c1ccccc1)C(C)C by removing a amide.,CNC(=O)c1ccccc1NC(=O)C[C@H](c1ccccc1)C(C)C,amide
+61863,Please remove a amide from the molecule CCO[C@H](C)c1nc(CC(=O)Nc2cccc(-c3cn[nH]c3)c2)cs1.,CCO[C@H](C)c1nc(CC(=O)Nc2cccc(-c3cn[nH]c3)c2)cs1,amide
+126104,Modify the molecule CC(=O)c1ccn(Cc2ccc([N+](=O)[O-])cc2Br)c1 by removing a nitro.,CC(=O)c1ccn(Cc2ccc([N+](=O)[O-])cc2Br)c1,nitro
+137979,Remove a halo from the molecule Cc1cc(Br)cnc1N1CCC[C@H]1CCC[NH3+].,Cc1cc(Br)cnc1N1CCC[C@H]1CCC[NH3+],halo
+28973,Modify the molecule C[NH2+][C@H]1CCN(CCc2ccc(F)cc2C)C1 by removing a benzene_ring.,C[NH2+][C@H]1CCN(CCc2ccc(F)cc2C)C1,benzene_ring
+138898,Modify the molecule COC(=O)c1cc(NC(=O)c2cc(C3CC3)nc3c2c(C)nn3C(C)(C)C)ccc1F by removing a benzene_ring.,COC(=O)c1cc(NC(=O)c2cc(C3CC3)nc3c2c(C)nn3C(C)(C)C)ccc1F,benzene_ring
+181435,Modify the molecule COc1c(Cl)cccc1NC(=O)C(=O)N[C@H]1C[C@@](C)(OC)C1(C)C by removing a benzene_ring.,COc1c(Cl)cccc1NC(=O)C(=O)N[C@H]1C[C@@](C)(OC)C1(C)C,benzene_ring
+28534,Remove a amide from the molecule Cc1nc(N(C)C)sc1C[NH+]1CCC[C@@H](CC(N)=O)C1.,Cc1nc(N(C)C)sc1C[NH+]1CCC[C@@H](CC(N)=O)C1,amide
+56649,Modify the molecule Cn1c(/C(C#N)=C/c2ccc(-c3ccc(S(=O)(=O)N4CCOCC4)cc3)o2)nc2ccccc21 by removing a benzene_ring.,Cn1c(/C(C#N)=C/c2ccc(-c3ccc(S(=O)(=O)N4CCOCC4)cc3)o2)nc2ccccc21,benzene_ring
+35125,Modify the molecule CC(C)(O)CC[C@H]1C[C@@H](C(C)(C)C)CCC1=O by removing a hydroxyl.,CC(C)(O)CC[C@H]1C[C@@H](C(C)(C)C)CCC1=O,hydroxyl
+171041,Remove a benzene_ring from the molecule CC[NH+]1CCN(c2ccc(N3CCC[C@H](C(=O)NCc4ccccc4)C3)nn2)CC1.,CC[NH+]1CCN(c2ccc(N3CCC[C@H](C(=O)NCc4ccccc4)C3)nn2)CC1,benzene_ring
+39183,Please remove a amide from the molecule NC(=O)c1cccc(CNC(=O)NCC2(N3CCOCC3)CCCCC2)c1.,NC(=O)c1cccc(CNC(=O)NCC2(N3CCOCC3)CCCCC2)c1,amide
+237918,Please remove a amide from the molecule Cn1nc(C(=O)Nc2ccccc2OC(F)(F)F)ccc1=O.,Cn1nc(C(=O)Nc2ccccc2OC(F)(F)F)ccc1=O,amide
+144587,Remove a amide from the molecule NC(=O)C(=O)NC1CCCCC1.,NC(=O)C(=O)NC1CCCCC1,amide
+34456,Please remove a hydroxyl from the molecule COC(=O)c1ccc(CSCCO)nc1.,COC(=O)c1ccc(CSCCO)nc1,hydroxyl
+38328,Modify the molecule CCC(=O)Oc1ccc2c(c1C)O/C(=C\c1cccc([N+](=O)[O-])c1)C2=O by removing a benzene_ring.,CCC(=O)Oc1ccc2c(c1C)O/C(=C\c1cccc([N+](=O)[O-])c1)C2=O,benzene_ring
+235954,Modify the molecule Cn1c(Cl)cnc1COC(=O)c1cc(Cl)c2c(c1)OCCO2 by removing a halo.,Cn1c(Cl)cnc1COC(=O)c1cc(Cl)c2c(c1)OCCO2,halo
+98989,Remove a hydroxyl from the molecule C[C@@H](C#N)[C@H](O)[C@H]1CC=CCC1.,C[C@@H](C#N)[C@H](O)[C@H]1CC=CCC1,hydroxyl
+2699,Please remove a amine from the molecule CC(=O)N1c2ccccc2NC2=C(C(=O)CCC2)[C@@H]1c1ccc(Cl)c(Cl)c1.,CC(=O)N1c2ccccc2NC2=C(C(=O)CCC2)[C@@H]1c1ccc(Cl)c(Cl)c1,amine
+17480,Remove a amide from the molecule COc1ccc(C(=O)NC[C@@H]2CCCC[C@@H]2C[NH3+])cc1O.,COc1ccc(C(=O)NC[C@@H]2CCCC[C@@H]2C[NH3+])cc1O,amide
+50098,Modify the molecule CC[C@@H]1CCCC[C@@H]1NC(=O)C[C@H]1OCCc2ccccc21 by removing a amide.,CC[C@@H]1CCCC[C@@H]1NC(=O)C[C@H]1OCCc2ccccc21,amide
+154462,Please remove a hydroxyl from the molecule COc1cc(/C=N/NC(=O)COc2cc(C)c(Cl)c(C)c2Br)ccc1O.,COc1cc(/C=N/NC(=O)COc2cc(C)c(Cl)c(C)c2Br)ccc1O,hydroxyl
+74420,Modify the molecule CC(=O)N(C(C)=O)c1ccccc1/C=C1/CCOC1=O by removing a benzene_ring.,CC(=O)N(C(C)=O)c1ccccc1/C=C1/CCOC1=O,benzene_ring
+67834,Please remove a benzene_ring from the molecule COc1ccc(OCCNC(=O)N[C@@H]2CCC[C@@H]([NH+](C)C)C2)cc1.,COc1ccc(OCCNC(=O)N[C@@H]2CCC[C@@H]([NH+](C)C)C2)cc1,benzene_ring
+45718,Please remove a amine from the molecule CCOC(=O)c1noc2nc(C)nc(NCCC3=CCCCC3)c12.,CCOC(=O)c1noc2nc(C)nc(NCCC3=CCCCC3)c12,amine
+212051,Please remove a benzene_ring from the molecule C[C@H]1C[C@@H]([NH2+]Cc2ccccn2)CCN1Cc1ccccc1.,C[C@H]1C[C@@H]([NH2+]Cc2ccccn2)CCN1Cc1ccccc1,benzene_ring
+85152,Please remove a benzene_ring from the molecule CCO[C@@H]1CCC[NH+](CC(=O)N(C)[C@@H](C)c2ccc(Cl)cc2)C1.,CCO[C@@H]1CCC[NH+](CC(=O)N(C)[C@@H](C)c2ccc(Cl)cc2)C1,benzene_ring
+211623,Remove a amide from the molecule Cc1nc2c(c(C)c1CCC(=O)NCc1ccc(=O)[nH]c1)c(=O)[nH]n2C.,Cc1nc2c(c(C)c1CCC(=O)NCc1ccc(=O)[nH]c1)c(=O)[nH]n2C,amide
+133690,Modify the molecule C[C@@H]1CCN(C(=O)N[C@@H]2CCC[C@@H]2c2ccc(F)cc2)C[C@H]1O by removing a halo.,C[C@@H]1CCN(C(=O)N[C@@H]2CCC[C@@H]2c2ccc(F)cc2)C[C@H]1O,halo
+35983,Remove a benzene_ring from the molecule O=C1N[C@H](c2ccc(Cl)c(F)c2)Nc2ccccc21.,O=C1N[C@H](c2ccc(Cl)c(F)c2)Nc2ccccc21,benzene_ring
+237623,Modify the molecule C[C@H]([NH3+])C(=O)N[C@H]1CCCC[C@H]1[NH+](Cc1ccccc1)C1CC1 by removing a benzene_ring.,C[C@H]([NH3+])C(=O)N[C@H]1CCCC[C@H]1[NH+](Cc1ccccc1)C1CC1,benzene_ring
+33463,Remove a amide from the molecule O=C(COCc1nc2ccccc2s1)Nc1ccccc1N1CCCC1=O.,O=C(COCc1nc2ccccc2s1)Nc1ccccc1N1CCCC1=O,amide
+90698,Modify the molecule C[C@H](O)C(=O)N1CCN(Cc2ccc(-c3nc4ccccc4s3)o2)CC1 by removing a amide.,C[C@H](O)C(=O)N1CCN(Cc2ccc(-c3nc4ccccc4s3)o2)CC1,amide
+51652,Modify the molecule O=C(Nc1ccc(F)cc1)N[C@@H]1CCN(Cn2nccc2-c2ccncc2)C1 by removing a halo.,O=C(Nc1ccc(F)cc1)N[C@@H]1CCN(Cn2nccc2-c2ccncc2)C1,halo
+177249,Remove a benzene_ring from the molecule Cc1ccc([C@@H]2CC=CC[C@@H]2[N+](=O)[O-])cc1.,Cc1ccc([C@@H]2CC=CC[C@@H]2[N+](=O)[O-])cc1,benzene_ring
+17561,Modify the molecule CC(C)c1nc(C(=O)N[C@H](C)c2ccc(Cl)cc2Cl)n[nH]1 by removing a amide.,CC(C)c1nc(C(=O)N[C@H](C)c2ccc(Cl)cc2Cl)n[nH]1,amide
+182984,Remove a benzene_ring from the molecule C=CCc1cc(/C=N/NC(=O)Nc2ccc(F)cc2)cc(OCC)c1O.,C=CCc1cc(/C=N/NC(=O)Nc2ccc(F)cc2)cc(OCC)c1O,benzene_ring
+63740,Please remove a amide from the molecule Cc1cc(O[C@H](C)C(=O)Nc2cc([N+](=O)[O-])ccc2C)ccc1Cl.,Cc1cc(O[C@H](C)C(=O)Nc2cc([N+](=O)[O-])ccc2C)ccc1Cl,amide
+797,Modify the molecule COCCn1nc(C)c(NC(=O)N2CCC[C@H]2c2cccc(C)c2)c1C by removing a benzene_ring.,COCCn1nc(C)c(NC(=O)N2CCC[C@H]2c2cccc(C)c2)c1C,benzene_ring
+153213,Remove a amide from the molecule O=C(CN1CCCOC1=O)NCCc1nc(C(F)(F)F)cs1.,O=C(CN1CCCOC1=O)NCCc1nc(C(F)(F)F)cs1,amide
+164211,Modify the molecule C[C@H]1CCC[C@H](C)N1C(=O)CCC(=O)N1[C@H](C)CCC[C@H]1C by removing a amide.,C[C@H]1CCC[C@H](C)N1C(=O)CCC(=O)N1[C@H](C)CCC[C@H]1C,amide
+89730,Modify the molecule O=S(=O)(c1ccc(F)cc1)N1CCN(Cc2cnc3ccccn23)CC1 by removing a benzene_ring.,O=S(=O)(c1ccc(F)cc1)N1CCN(Cc2cnc3ccccn23)CC1,benzene_ring
+189242,Remove a amide from the molecule CCN(CC1CC[NH2+]CC1)C(=O)Cc1cccs1.,CCN(CC1CC[NH2+]CC1)C(=O)Cc1cccs1,amide
+244882,Modify the molecule CSc1ccc(C(C)=O)cc1F by removing a halo.,CSc1ccc(C(C)=O)cc1F,halo
+87469,Please remove a nitro from the molecule Cc1ccccc1OCC(=O)N1CCN(c2ccc([N+](=O)[O-])c(N3CCOCC3)c2)CC1.,Cc1ccccc1OCC(=O)N1CCN(c2ccc([N+](=O)[O-])c(N3CCOCC3)c2)CC1,nitro
+159737,Remove a benzene_ring from the molecule CC(C)NC(=O)CN(C)C(=O)CCc1nncn1-c1ccccc1.,CC(C)NC(=O)CN(C)C(=O)CCc1nncn1-c1ccccc1,benzene_ring
+170411,Modify the molecule Cc1cc(F)cc(Nc2ccc(Cl)cn2)c1 by removing a benzene_ring.,Cc1cc(F)cc(Nc2ccc(Cl)cn2)c1,benzene_ring
+243084,Please remove a halo from the molecule Cc1nc(C)c(C(=O)C2=C([O-])C(=O)N(CCc3ccccc3)[C@@H]2c2ccc(F)cc2)s1.,Cc1nc(C)c(C(=O)C2=C([O-])C(=O)N(CCc3ccccc3)[C@@H]2c2ccc(F)cc2)s1,halo
+47774,Modify the molecule Cc1nn(C)c(C)c1CC(=O)[C@@H](C#N)c1ncc(C(F)(F)F)cc1Cl by removing a nitrile.,Cc1nn(C)c(C)c1CC(=O)[C@@H](C#N)c1ncc(C(F)(F)F)cc1Cl,nitrile
+154413,Please remove a amide from the molecule C[C@@]1(CSc2ccccc2C(=O)N2CC[C@H]3CCCC[C@@H]3C2)NC(=O)NC1=O.,C[C@@]1(CSc2ccccc2C(=O)N2CC[C@H]3CCCC[C@@H]3C2)NC(=O)NC1=O,amide
+211065,Please remove a amine from the molecule CNS(=O)(=O)c1ccc(-c2ccc(OC)cc2)cc1.,CNS(=O)(=O)c1ccc(-c2ccc(OC)cc2)cc1,amine
+178119,Modify the molecule CN1CCc2nc3sc4c5c(c(=O)[nH]c4c3cc2C1)[C@@H](c1ccc(F)cc1)C(C#N)=C(N)O5 by removing a halo.,CN1CCc2nc3sc4c5c(c(=O)[nH]c4c3cc2C1)[C@@H](c1ccc(F)cc1)C(C#N)=C(N)O5,halo
+197734,Modify the molecule Cn1nc(CC(C)(C)C)cc1NC(=O)C(=O)N[C@H]1C[C@H]1C1CCCCC1 by removing a amide.,Cn1nc(CC(C)(C)C)cc1NC(=O)C(=O)N[C@H]1C[C@H]1C1CCCCC1,amide
+205955,Modify the molecule CCNC(=O)Nc1ccccc1OC by removing a benzene_ring.,CCNC(=O)Nc1ccccc1OC,benzene_ring
+158609,Please remove a halo from the molecule CCCc1cc(NC(=O)c2ncccc2C(F)(F)F)n[nH]1.,CCCc1cc(NC(=O)c2ncccc2C(F)(F)F)n[nH]1,halo
+213711,Remove a halo from the molecule O=C(NC[C@@H]1Cc2cc(F)cc(-c3ncccn3)c2O1)c1noc2c1CCCC2.,O=C(NC[C@@H]1Cc2cc(F)cc(-c3ncccn3)c2O1)c1noc2c1CCCC2,halo
+22661,Modify the molecule Cc1ccc(C#N)c(N[C@H]2CCc3cc(N)ccc32)n1 by removing a nitrile.,Cc1ccc(C#N)c(N[C@H]2CCc3cc(N)ccc32)n1,nitrile
+88137,Modify the molecule O=C(CSc1nnc(NC(=O)Cc2ccccc2)s1)Nc1ccc2c(c1)OCCO2 by removing a amide.,O=C(CSc1nnc(NC(=O)Cc2ccccc2)s1)Nc1ccc2c(c1)OCCO2,amide
+82097,Please remove a benzene_ring from the molecule COc1ccc(-c2nnc(SCC(C)=O)n2C2CCCCC2)cc1.,COc1ccc(-c2nnc(SCC(C)=O)n2C2CCCCC2)cc1,benzene_ring
+6612,Please remove a nitrile from the molecule C[S@](=O)c1ccc(CNc2cc(C#N)nc3ccccc23)cc1.,C[S@](=O)c1ccc(CNc2cc(C#N)nc3ccccc23)cc1,nitrile
+234369,Please remove a amide from the molecule CC[NH+](CC)Cc1nc(C2(NC(=O)C3CC=CC3)CCCC2)no1.,CC[NH+](CC)Cc1nc(C2(NC(=O)C3CC=CC3)CCCC2)no1,amide
+35049,Please remove a benzene_ring from the molecule CN(C)/C=C/C(=O)c1ccc(Sc2ccccc2)cc1.,CN(C)/C=C/C(=O)c1ccc(Sc2ccccc2)cc1,benzene_ring
+66903,Modify the molecule Cc1csc(C[S@](=O)Cc2coc(-c3ccc(F)c(F)c3)n2)n1 by removing a halo.,Cc1csc(C[S@](=O)Cc2coc(-c3ccc(F)c(F)c3)n2)n1,halo
+54338,Please remove a amide from the molecule Cc1ccoc1C(=O)N1CC[NH+](Cc2ccc3c(c2)OCCO3)CC1.,Cc1ccoc1C(=O)N1CC[NH+](Cc2ccc3c(c2)OCCO3)CC1,amide
+21679,Modify the molecule C[C@@H]1OCC[C@@H]1C(=O)c1ccc(Br)cc1 by removing a benzene_ring.,C[C@@H]1OCC[C@@H]1C(=O)c1ccc(Br)cc1,benzene_ring
+236870,Please remove a benzene_ring from the molecule CO[C@@H](C)C(=O)NNC(=O)CNc1ccc(C)cc1.,CO[C@@H](C)C(=O)NNC(=O)CNc1ccc(C)cc1,benzene_ring
+172490,Modify the molecule C[C@@H](C(=O)Nc1ccc(Cl)cc1)S(=O)(=O)c1ccc(O)cc1 by removing a halo.,C[C@@H](C(=O)Nc1ccc(Cl)cc1)S(=O)(=O)c1ccc(O)cc1,halo
+7789,Remove a benzene_ring from the molecule Cc1ccc(N(CCOC(=O)c2cccnc2)C2=NS(=O)(=O)c3ccccc32)cc1.,Cc1ccc(N(CCOC(=O)c2cccnc2)C2=NS(=O)(=O)c3ccccc32)cc1,benzene_ring
+159075,Modify the molecule O=C(NCc1cccnc1)C(=O)NC[C@@H](c1cccs1)N1CCc2ccccc21 by removing a amide.,O=C(NCc1cccnc1)C(=O)NC[C@@H](c1cccs1)N1CCc2ccccc21,amide
+43439,Modify the molecule C[C@H](N[C@H](C)CC(=O)N1CCCCCC1)C(=O)OC(C)(C)C by removing a amine.,C[C@H](N[C@H](C)CC(=O)N1CCCCCC1)C(=O)OC(C)(C)C,amine
+159851,Modify the molecule C#CCNC(=O)[C@@H]1CCO[C@H]1C by removing a amide.,C#CCNC(=O)[C@@H]1CCO[C@H]1C,amide
+207014,Remove a benzene_ring from the molecule CCc1ccccc1[N-]S(=O)(=O)c1cc(-c2nc(C)c(C(=O)N3CCCC3)s2)n(C)c1C.,CCc1ccccc1[N-]S(=O)(=O)c1cc(-c2nc(C)c(C(=O)N3CCCC3)s2)n(C)c1C,benzene_ring
+190498,Please remove a benzene_ring from the molecule Cc1cc(N/N=C2/C[C@H](c3ccccc3)Oc3ccccc32)nc(C)n1.,Cc1cc(N/N=C2/C[C@H](c3ccccc3)Oc3ccccc32)nc(C)n1,benzene_ring
+246971,Modify the molecule COc1ccc([C@H](NC(=O)NC[C@@H](C)N2CCOCC2)C(C)C)cc1 by removing a benzene_ring.,COc1ccc([C@H](NC(=O)NC[C@@H](C)N2CCOCC2)C(C)C)cc1,benzene_ring
+88698,Remove a amine from the molecule O=C(NNc1cccnc1Cl)c1sccc1OC(F)F.,O=C(NNc1cccnc1Cl)c1sccc1OC(F)F,amine
+129334,Modify the molecule O=C(NC[C@H]1COc2ccccc2O1)c1cc(-c2ccco2)nn1-c1ccccc1 by removing a benzene_ring.,O=C(NC[C@H]1COc2ccccc2O1)c1cc(-c2ccco2)nn1-c1ccccc1,benzene_ring
+132763,Modify the molecule CC[C@@H](C)NC(=O)CCNC(=O)N[C@@H](C)C(C)C by removing a amide.,CC[C@@H](C)NC(=O)CCNC(=O)N[C@@H](C)C(C)C,amide
+97442,Modify the molecule C[S@@](=O)c1ccc(CNC(=O)NC[C@@H](O)c2ccc(F)cc2)cc1 by removing a hydroxyl.,C[S@@](=O)c1ccc(CNC(=O)NC[C@@H](O)c2ccc(F)cc2)cc1,hydroxyl
+55265,Modify the molecule C[C@H]1CN(S(=O)(=O)c2cccc([N+](=O)[O-])c2)C[C@H](C)O1 by removing a nitro.,C[C@H]1CN(S(=O)(=O)c2cccc([N+](=O)[O-])c2)C[C@H](C)O1,nitro
+242161,Modify the molecule CCN1C(=O)[C@H](CC(=O)Nc2cc(Cl)ccc2C)S/C1=N\c1ccc(S(N)(=O)=O)cc1 by removing a benzene_ring.,CCN1C(=O)[C@H](CC(=O)Nc2cc(Cl)ccc2C)S/C1=N\c1ccc(S(N)(=O)=O)cc1,benzene_ring
+238273,Modify the molecule CC1(C)[C@H]2CC[C@@](O)(C[NH3+])[C@@H]1C2 by removing a hydroxyl.,CC1(C)[C@H]2CC[C@@](O)(C[NH3+])[C@@H]1C2,hydroxyl
+47360,Remove a benzene_ring from the molecule CCc1ccc(NC(=O)[C@H]2CCN(C(=O)OC(C)(C)C)C2)cc1.,CCc1ccc(NC(=O)[C@H]2CCN(C(=O)OC(C)(C)C)C2)cc1,benzene_ring
+153544,Modify the molecule CCC[C@H]1C[NH2+]CC[C@@H]1c1ccc(OC)cc1 by removing a benzene_ring.,CCC[C@H]1C[NH2+]CC[C@@H]1c1ccc(OC)cc1,benzene_ring
+30936,Modify the molecule CCOC(=O)CCCNc1ncnc2ccccc12 by removing a amine.,CCOC(=O)CCCNc1ncnc2ccccc12,amine
+14543,Remove a benzene_ring from the molecule CCC(C)(C)c1ccc(OC[C@H](C)C[NH3+])cc1.,CCC(C)(C)c1ccc(OC[C@H](C)C[NH3+])cc1,benzene_ring
+119600,Please remove a amide from the molecule C[C@]12CN(Cc3ccccc3)C[C@@H]1NC(=O)c1ccccc1[C@@H]2[NH3+].,C[C@]12CN(Cc3ccccc3)C[C@@H]1NC(=O)c1ccccc1[C@@H]2[NH3+],amide
+153759,Remove a halo from the molecule CC[C@H](C#N)OC(=O)c1ccn(-c2ccccc2Cl)n1.,CC[C@H](C#N)OC(=O)c1ccn(-c2ccccc2Cl)n1,halo
+124408,Modify the molecule Cc1ccc(CCNC(=O)C[C@H](O)c2cccc(F)c2)c(C)c1 by removing a amide.,Cc1ccc(CCNC(=O)C[C@H](O)c2cccc(F)c2)c(C)c1,amide
+37791,Please remove a benzene_ring from the molecule CC(C)Cc1ccc([C@H](C)c2nn3c(-c4ccccn4)nnc3s2)cc1.,CC(C)Cc1ccc([C@H](C)c2nn3c(-c4ccccn4)nnc3s2)cc1,benzene_ring
+47226,Modify the molecule F[C@H]1CCCC[C@@H]1Br by removing a halo.,F[C@H]1CCCC[C@@H]1Br,halo
+57876,Please remove a hydroxyl from the molecule C[C@H](CNC(=O)N[C@@H]1CCc2c(O)cccc21)c1cccs1.,C[C@H](CNC(=O)N[C@@H]1CCc2c(O)cccc21)c1cccs1,hydroxyl
+140986,Please remove a amide from the molecule CCC[C@@H]1CN(C(=O)c2ccc(=O)[nH]c2)C[C@H]1[NH+](C)C.,CCC[C@@H]1CN(C(=O)c2ccc(=O)[nH]c2)C[C@H]1[NH+](C)C,amide
+18784,Please remove a halo from the molecule COc1ccc(-c2ccc(C[NH2+]Cc3ccc4c(c3)OCO4)o2)cc1Cl.,COc1ccc(-c2ccc(C[NH2+]Cc3ccc4c(c3)OCO4)o2)cc1Cl,halo
+30862,Modify the molecule COc1ccc(NC(=O)[C@@H](C)Cc2ccccc2F)c(C)c1 by removing a amide.,COc1ccc(NC(=O)[C@@H](C)Cc2ccccc2F)c(C)c1,amide
+159455,Remove a amide from the molecule O=C1[C@H](Oc2ccccc2)[C@H](c2cccs2)N1Cc1ccc2c(c1)OCO2.,O=C1[C@H](Oc2ccccc2)[C@H](c2cccs2)N1Cc1ccc2c(c1)OCO2,amide
+136653,Remove a nitrile from the molecule C[C@H](NC(=O)N[C@@H]1C[C@@H]1C)c1ccc(C#N)cc1.,C[C@H](NC(=O)N[C@@H]1C[C@@H]1C)c1ccc(C#N)cc1,nitrile
+32653,Modify the molecule CCCCN/C([O-])=N/S(=O)(=O)c1ccccc1-c1ccccc1 by removing a amine.,CCCCN/C([O-])=N/S(=O)(=O)c1ccccc1-c1ccccc1,amine
+55314,Modify the molecule COc1cccc(C#CCOC(=O)c2cn(C)nc2C(C)(C)C)c1 by removing a benzene_ring.,COc1cccc(C#CCOC(=O)c2cn(C)nc2C(C)(C)C)c1,benzene_ring
+81015,Modify the molecule c1ccc(Cn2nnnc2CN2CC[NH+](Cc3ccc4c(c3)OCO4)CC2)cc1 by removing a benzene_ring.,c1ccc(Cn2nnnc2CN2CC[NH+](Cc3ccc4c(c3)OCO4)CC2)cc1,benzene_ring
+1730,Please remove a amide from the molecule O=C(NNc1cccc(C(F)(F)F)c1)c1cccc2cccnc12.,O=C(NNc1cccc(C(F)(F)F)c1)c1cccc2cccnc12,amide
+246966,Please remove a amide from the molecule CN1CC[C@H](CNC(=O)Cn2ccc(=O)[nH]c2=O)c2ccccc21.,CN1CC[C@H](CNC(=O)Cn2ccc(=O)[nH]c2=O)c2ccccc21,amide
+168204,Please remove a halo from the molecule C[C@H](CNC(=O)NC[C@@H]1CCC[C@H](O)C1)c1ccc(F)c(F)c1.,C[C@H](CNC(=O)NC[C@@H]1CCC[C@H](O)C1)c1ccc(F)c(F)c1,halo
+218715,Remove a hydroxyl from the molecule CC[NH2+][C@]1(CO)CC[C@H](Sc2nnc3ccccn23)C1.,CC[NH2+][C@]1(CO)CC[C@H](Sc2nnc3ccccn23)C1,hydroxyl
+52961,Please remove a benzene_ring from the molecule COc1ccc2c(c1)=[NH+][C@@H](C(=O)N1CCC([C@H](C)C(=O)NCc3ccc(Cl)cc3)CC1)C=2.,COc1ccc2c(c1)=[NH+][C@@H](C(=O)N1CCC([C@H](C)C(=O)NCc3ccc(Cl)cc3)CC1)C=2,benzene_ring
+95187,Modify the molecule O[C@@H](C[NH+]1CCC(Oc2ccccc2)CC1)c1cccc(Cl)c1 by removing a benzene_ring.,O[C@@H](C[NH+]1CCC(Oc2ccccc2)CC1)c1cccc(Cl)c1,benzene_ring
+100923,Please remove a amide from the molecule Cc1ccc([C@@H](C)NC(=O)c2cccc(-n3cccn3)n2)o1.,Cc1ccc([C@@H](C)NC(=O)c2cccc(-n3cccn3)n2)o1,amide
+217222,Modify the molecule C[C@@H]1CCC[C@H]1NC(=O)Nc1cccn(Cc2ccc(F)cc2)c1=O by removing a benzene_ring.,C[C@@H]1CCC[C@H]1NC(=O)Nc1cccn(Cc2ccc(F)cc2)c1=O,benzene_ring
+47475,Please remove a benzene_ring from the molecule COc1ccccc1C(=O)[C@@H]1CCOC2(CCOCC2)C1.,COc1ccccc1C(=O)[C@@H]1CCOC2(CCOCC2)C1,benzene_ring
+108025,Remove a thiol from the molecule Sc1sccc1/C=N/c1ccc2ccccc2c1.,Sc1sccc1/C=N/c1ccc2ccccc2c1,thiol
+181573,Please remove a benzene_ring from the molecule C[C@@H](NC(=O)C(=O)Nc1ccc2c(c1)COC2)c1cccc(-n2cccn2)c1.,C[C@@H](NC(=O)C(=O)Nc1ccc2c(c1)COC2)c1cccc(-n2cccn2)c1,benzene_ring
+30115,Remove a halo from the molecule COc1ccc(C(=O)O[C@@H](C)[C@H]2CCCO2)cc1F.,COc1ccc(C(=O)O[C@@H](C)[C@H]2CCCO2)cc1F,halo
+15445,Please remove a benzene_ring from the molecule CC(=O)C1=C(C)C(C(=O)NCc2ccc(-n3ccnc3)cc2)=N[C@H]1C.,CC(=O)C1=C(C)C(C(=O)NCc2ccc(-n3ccnc3)cc2)=N[C@H]1C,benzene_ring
+67168,Modify the molecule C[C@@H]1[NH2+]CC[C@@H]1C(=O)Nc1cc(F)cc(F)c1 by removing a halo.,C[C@@H]1[NH2+]CC[C@@H]1C(=O)Nc1cc(F)cc(F)c1,halo
+228884,Please remove a amide from the molecule CN(/C([O-])=N/c1ncnn1C)[C@@H]1CCCN(c2ccccc2)C1=O.,CN(/C([O-])=N/c1ncnn1C)[C@@H]1CCCN(c2ccccc2)C1=O,amide
+70664,Remove a benzene_ring from the molecule COc1ccc(-c2csc(CNC(=O)c3cc(C)no3)c2)cc1.,COc1ccc(-c2csc(CNC(=O)c3cc(C)no3)c2)cc1,benzene_ring
+6304,Modify the molecule Cc1ccc(-c2nnn(CC(=O)N[C@H]3CCCn4c(C)nnc43)n2)cc1 by removing a amide.,Cc1ccc(-c2nnn(CC(=O)N[C@H]3CCCn4c(C)nnc43)n2)cc1,amide
+42099,Please remove a amide from the molecule O=C(NCc1ccon1)c1cc2ccccc2c(Cl)n1.,O=C(NCc1ccon1)c1cc2ccccc2c(Cl)n1,amide
+29706,Please remove a benzene_ring from the molecule Cc1ccc(Cn2ccc3cc(CO)ccc32)cc1.,Cc1ccc(Cn2ccc3cc(CO)ccc32)cc1,benzene_ring
+182253,Remove a benzene_ring from the molecule COc1ccc(CNC(=O)NC2CC[NH+](C[C@@H]3CCOC3)CC2)cc1.,COc1ccc(CNC(=O)NC2CC[NH+](C[C@@H]3CCOC3)CC2)cc1,benzene_ring
+166655,Modify the molecule O=C(Nc1cc(N2CCCC2=O)ccc1Cl)N1CC[C@@H]([NH+]2CCCC2)C1 by removing a amide.,O=C(Nc1cc(N2CCCC2=O)ccc1Cl)N1CC[C@@H]([NH+]2CCCC2)C1,amide
+223080,Modify the molecule CCOCCCNC(=O)[C@@H]1CC(=O)N(c2ccc(Cl)cc2)C1 by removing a amide.,CCOCCCNC(=O)[C@@H]1CC(=O)N(c2ccc(Cl)cc2)C1,amide
+57771,Remove a halo from the molecule CC(C)(C)c1csc(C[C@H]2CCC[C@H](Br)C2)n1.,CC(C)(C)c1csc(C[C@H]2CCC[C@H](Br)C2)n1,halo
+164202,Please remove a amide from the molecule O=C(NC12CC3CC(CC(C3)C1)C2)c1csc(-c2cnccn2)n1.,O=C(NC12CC3CC(CC(C3)C1)C2)c1csc(-c2cnccn2)n1,amide
+39666,Remove a amide from the molecule COC1CC[NH+](CCNC(=O)c2cc(C)n(-c3cc(C)on3)c2C)CC1.,COC1CC[NH+](CCNC(=O)c2cc(C)n(-c3cc(C)on3)c2C)CC1,amide
+11174,Modify the molecule [O-]/[N+](=C\c1ccc(O)cc1)c1ccc(Cl)cc1 by removing a halo.,[O-]/[N+](=C\c1ccc(O)cc1)c1ccc(Cl)cc1,halo
+42120,Remove a halo from the molecule CC1(C)CCC[C@@H](Sc2ccc(Cl)cc2)[C@H]1[NH3+].,CC1(C)CCC[C@@H](Sc2ccc(Cl)cc2)[C@H]1[NH3+],halo
+17225,Modify the molecule CCN1CC(=O)Nc2cc(C(=O)O[C@@H](C)C3CC3)ccc21 by removing a amide.,CCN1CC(=O)Nc2cc(C(=O)O[C@@H](C)C3CC3)ccc21,amide
+64378,Remove a amide from the molecule CN(CCc1ccccc1)C(=O)c1ccc[n+]([O-])c1.,CN(CCc1ccccc1)C(=O)c1ccc[n+]([O-])c1,amide
+102389,Please remove a hydroxyl from the molecule CC(C)[C@H](C(=O)N(C)C[C@H]1CCC[NH+]1C)/C(N)=N/O.,CC(C)[C@H](C(=O)N(C)C[C@H]1CCC[NH+]1C)/C(N)=N/O,hydroxyl
+175631,Modify the molecule CCC(C)(C)[C@@H]1CCCN1C(=O)c1cnc2sc(C)cn2c1=O by removing a amide.,CCC(C)(C)[C@@H]1CCCN1C(=O)c1cnc2sc(C)cn2c1=O,amide
+141860,Modify the molecule Cc1c(NC2=NCCS2)c(=O)n(-c2ccccc2)n1C by removing a amine.,Cc1c(NC2=NCCS2)c(=O)n(-c2ccccc2)n1C,amine
+117082,Please remove a amide from the molecule COc1ccc(N2CCN(C(=O)C[C@@H]3C(=O)NCC[NH+]3C3CCCC3)CC2)cc1.,COc1ccc(N2CCN(C(=O)C[C@@H]3C(=O)NCC[NH+]3C3CCCC3)CC2)cc1,amide
+217536,Please remove a amide from the molecule C[C@H](NC(=O)[C@@H]1CCO[C@@H]1C)C(=O)NC(C)(C)C.,C[C@H](NC(=O)[C@@H]1CCO[C@@H]1C)C(=O)NC(C)(C)C,amide
+102534,Remove a benzene_ring from the molecule O=C1NCC(=O)N2CCN(C(=O)c3cnnn3-c3ccccc3)C[C@@H]12.,O=C1NCC(=O)N2CCN(C(=O)c3cnnn3-c3ccccc3)C[C@@H]12,benzene_ring
+234504,Modify the molecule Cc1cccc(C(=O)N/N=C/c2cc3ccc(C)cc3nc2Cl)c1 by removing a benzene_ring.,Cc1cccc(C(=O)N/N=C/c2cc3ccc(C)cc3nc2Cl)c1,benzene_ring
+98073,Modify the molecule C=CC[C@H](Sc1nnnn1-c1ccc(Cl)cc1)c1ccccc1 by removing a halo.,C=CC[C@H](Sc1nnnn1-c1ccc(Cl)cc1)c1ccccc1,halo
+187709,Remove a amide from the molecule CNc1cc([C@H]2CCCN(C(=O)CC(C)(C)C)C2)nc(-c2cccnc2)n1.,CNc1cc([C@H]2CCCN(C(=O)CC(C)(C)C)C2)nc(-c2cccnc2)n1,amide
+103706,Modify the molecule COc1c(Br)cccc1C[NH2+]Cc1ccco1 by removing a halo.,COc1c(Br)cccc1C[NH2+]Cc1ccco1,halo
+244320,Please remove a amide from the molecule CCOc1ccc(C(=O)N[C@@]2(C)CCS(=O)(=O)C2)cn1.,CCOc1ccc(C(=O)N[C@@]2(C)CCS(=O)(=O)C2)cn1,amide
+91206,Modify the molecule CC(C)[NH2+]C[C@@H](O)CN(C)C[C@@H]1CCC[NH+]1C by removing a hydroxyl.,CC(C)[NH2+]C[C@@H](O)CN(C)C[C@@H]1CCC[NH+]1C,hydroxyl
+32658,Please remove a benzene_ring from the molecule CC[C@H](Oc1ccccc1)C(=O)Nc1cccc(C(=O)Nc2ccccc2)c1.,CC[C@H](Oc1ccccc1)C(=O)Nc1cccc(C(=O)Nc2ccccc2)c1,benzene_ring
+101939,Please remove a benzene_ring from the molecule C[S@](=O)c1ccc(C[NH2+]C[C@H]2CN3CCCC[C@@H]3CO2)cc1.,C[S@](=O)c1ccc(C[NH2+]C[C@H]2CN3CCCC[C@@H]3CO2)cc1,benzene_ring
+130454,Remove a amide from the molecule C=CCN1CCN(C2CCN(S(=O)(=O)c3ccccc3CC)CC2)C(=O)C1=O.,C=CCN1CCN(C2CCN(S(=O)(=O)c3ccccc3CC)CC2)C(=O)C1=O,amide
+244746,Modify the molecule O=C(Cn1cnnn1)NC1(c2cccc(C(F)(F)F)c2)CCCCC1 by removing a amide.,O=C(Cn1cnnn1)NC1(c2cccc(C(F)(F)F)c2)CCCCC1,amide
+134045,Please remove a benzene_ring from the molecule CCC[C@@H](NC(=O)c1ccc(Cl)c(OC)c1)C(=O)OC.,CCC[C@@H](NC(=O)c1ccc(Cl)c(OC)c1)C(=O)OC,benzene_ring
+522,Modify the molecule CC(C)c1ccc2oc(-c3ccc(C[NH3+])cc3)nc2c1 by removing a benzene_ring.,CC(C)c1ccc2oc(-c3ccc(C[NH3+])cc3)nc2c1,benzene_ring
+209263,Modify the molecule C[C@H](O)[C@@H]1CCCC[NH+]1Cc1cc(C#N)cs1 by removing a hydroxyl.,C[C@H](O)[C@@H]1CCCC[NH+]1Cc1cc(C#N)cs1,hydroxyl
+96247,Modify the molecule Cc1ccc(O[C@@H](C)C(=O)NC(N)=O)c(C=O)n1 by removing a aldehyde.,Cc1ccc(O[C@@H](C)C(=O)NC(N)=O)c(C=O)n1,aldehyde
+221173,Please remove a halo from the molecule CCc1cccc(CC)c1NC(=O)CSc1nnc(-c2ccc(F)cc2)o1.,CCc1cccc(CC)c1NC(=O)CSc1nnc(-c2ccc(F)cc2)o1,halo
+50316,Modify the molecule C[C@H]1CCN(C(=O)C[C@@H]2CCCc3ccccc32)C[C@@H]1O by removing a amide.,C[C@H]1CCN(C(=O)C[C@@H]2CCCc3ccccc32)C[C@@H]1O,amide
+7521,Modify the molecule CCOC(=O)c1cccc(N[C@H]2CS[C@@H](C)C2)c1 by removing a amine.,CCOC(=O)c1cccc(N[C@H]2CS[C@@H](C)C2)c1,amine
+226564,Please remove a amide from the molecule O=C(Cn1ncn2nccc2c1=O)N1CCC[C@@H](n2cncn2)C1.,O=C(Cn1ncn2nccc2c1=O)N1CCC[C@@H](n2cncn2)C1,amide
+206333,Please remove a benzene_ring from the molecule O=C(Cc1ccc(Cl)cc1)N1CCC[C@@H]1c1cccs1.,O=C(Cc1ccc(Cl)cc1)N1CCC[C@@H]1c1cccs1,benzene_ring
+48367,Please remove a amide from the molecule O=C(Cc1ccncc1)NNC(=O)N[C@@H]1CCCC[C@H]1Cc1ccccc1.,O=C(Cc1ccncc1)NNC(=O)N[C@@H]1CCCC[C@H]1Cc1ccccc1,amide
+50495,Remove a halo from the molecule C[NH2+][C@@H](COC(C)C)c1ncc(Cl)cc1Cl.,C[NH2+][C@@H](COC(C)C)c1ncc(Cl)cc1Cl,halo
+206578,Modify the molecule OC1=Nc2c(cnn2Cc2ccccc2)[C@@H](c2ccc(F)c(F)c2F)SC1 by removing a hydroxyl.,OC1=Nc2c(cnn2Cc2ccccc2)[C@@H](c2ccc(F)c(F)c2F)SC1,hydroxyl
+86493,Please remove a halo from the molecule O=C(NCc1nc(-c2cccs2)n[nH]1)c1cc2cccc(Cl)c2o1.,O=C(NCc1nc(-c2cccs2)n[nH]1)c1cc2cccc(Cl)c2o1,halo
+152221,Please remove a amide from the molecule O=C(NC1C2CC3CC(C2)CC1C3)C1CCC1.,O=C(NC1C2CC3CC(C2)CC1C3)C1CCC1,amide
+56851,Please remove a benzene_ring from the molecule C[C@H]1CN(C(=O)c2ccc(-c3ncon3)cc2)C(C)(C)CO1.,C[C@H]1CN(C(=O)c2ccc(-c3ncon3)cc2)C(C)(C)CO1,benzene_ring
+102071,Please remove a nitrile from the molecule N#Cc1csc(C(=O)Oc2ccc(Br)cc2)c1.,N#Cc1csc(C(=O)Oc2ccc(Br)cc2)c1,nitrile
+29420,Please remove a benzene_ring from the molecule Oc1cccc(C[NH+]2CCC(n3cc(-c4ccccc4)nn3)CC2)c1.,Oc1cccc(C[NH+]2CCC(n3cc(-c4ccccc4)nn3)CC2)c1,benzene_ring
+104933,Modify the molecule ClC[C@@H]1CCO[C@@H]1c1cc(Br)c(Br)o1 by removing a halo.,ClC[C@@H]1CCO[C@@H]1c1cc(Br)c(Br)o1,halo
+239221,Remove a hydroxyl from the molecule O=S(=O)(Cc1cccc(F)c1)N[C@@H](CO)c1ccc(Cl)cc1.,O=S(=O)(Cc1cccc(F)c1)N[C@@H](CO)c1ccc(Cl)cc1,hydroxyl
+75746,Remove a halo from the molecule COc1cc(/C=C(\C#N)C(=O)Nc2ccc(Cl)cc2Cl)cc(OC)c1O.,COc1cc(/C=C(\C#N)C(=O)Nc2ccc(Cl)cc2Cl)cc(OC)c1O,halo
+209211,Please remove a benzene_ring from the molecule CN(CC1CC[NH2+]CC1)C[C@H](C#N)c1ccccc1.,CN(CC1CC[NH2+]CC1)C[C@H](C#N)c1ccccc1,benzene_ring
+91422,Please remove a benzene_ring from the molecule CCN(CC)C(=O)[C@@H]1CCC[NH+](C2CCN(CCc3ccccc3)CC2)C1.,CCN(CC)C(=O)[C@@H]1CCC[NH+](C2CCN(CCc3ccccc3)CC2)C1,benzene_ring
+56703,Modify the molecule CN(Cc1cccs1)C(=O)c1cc(C2CC2)nn1-c1ccccc1 by removing a benzene_ring.,CN(Cc1cccs1)C(=O)c1cc(C2CC2)nn1-c1ccccc1,benzene_ring
+244808,Modify the molecule COC(=O)c1ccc(C)c(OCC(=O)N(C2CCCC2)[C@@H]2CCS(=O)(=O)C2)c1 by removing a benzene_ring.,COC(=O)c1ccc(C)c(OCC(=O)N(C2CCCC2)[C@@H]2CCS(=O)(=O)C2)c1,benzene_ring
+156009,Modify the molecule C[C@H]1CCC[NH+](CCNC(=O)c2ccc(C(F)(F)F)cc2[N+](=O)[O-])C1 by removing a halo.,C[C@H]1CCC[NH+](CCNC(=O)c2ccc(C(F)(F)F)cc2[N+](=O)[O-])C1,halo
+97780,Modify the molecule CCN(CC)C(=O)c1ccc(Oc2snc(Cl)c2C#N)cc1 by removing a nitrile.,CCN(CC)C(=O)c1ccc(Oc2snc(Cl)c2C#N)cc1,nitrile
+137060,Remove a amide from the molecule Cc1ccccc1OCC(=O)NNC(=O)[C@@H](C)N1C(=O)c2ccccc2C1=O.,Cc1ccccc1OCC(=O)NNC(=O)[C@@H](C)N1C(=O)c2ccccc2C1=O,amide
+121388,Modify the molecule Cc1ccc(S(=O)(=O)N2CC[NH+](CC(=O)N/N=C\c3cccn3C)CC2)cc1 by removing a benzene_ring.,Cc1ccc(S(=O)(=O)N2CC[NH+](CC(=O)N/N=C\c3cccn3C)CC2)cc1,benzene_ring
+168013,Please remove a benzene_ring from the molecule COc1cc(-c2noc([C@H]3CC(=O)N(c4ccc(C)c(F)c4)C3)n2)cc(OC)c1OC.,COc1cc(-c2noc([C@H]3CC(=O)N(c4ccc(C)c(F)c4)C3)n2)cc(OC)c1OC,benzene_ring
+71457,Modify the molecule Cc1ncccc1C(=O)NCCCO by removing a hydroxyl.,Cc1ncccc1C(=O)NCCCO,hydroxyl
+136712,Please remove a halo from the molecule CCC[C@H]1CN(Cc2ccc(CSC(F)F)o2)CCO1.,CCC[C@H]1CN(Cc2ccc(CSC(F)F)o2)CCO1,halo
+171517,Please remove a halo from the molecule O=C(Nc1cccc(-c2noc(C3CCC3)n2)c1)Nc1ccc(F)c(Cl)c1.,O=C(Nc1cccc(-c2noc(C3CCC3)n2)c1)Nc1ccc(F)c(Cl)c1,halo
+239206,Modify the molecule CCCNC(=O)CN(CCC)C(=O)c1cc(C)ccc1C by removing a benzene_ring.,CCCNC(=O)CN(CCC)C(=O)c1cc(C)ccc1C,benzene_ring
+134140,Please remove a amine from the molecule [NH2+]=C(C1CC1)N1CC[NH+]2CCCC[C@H]2C1.,[NH2+]=C(C1CC1)N1CC[NH+]2CCCC[C@H]2C1,amine
+69200,Remove a amide from the molecule C[C@H](C(=O)N(C)C1CCCCC1)[NH+]1CCC(C(=O)N2CCCCC2)CC1.,C[C@H](C(=O)N(C)C1CCCCC1)[NH+]1CCC(C(=O)N2CCCCC2)CC1,amide
+117294,Modify the molecule O=C(Nc1ccc(Cl)nc1)c1ccc(Br)c(F)c1 by removing a benzene_ring.,O=C(Nc1ccc(Cl)nc1)c1ccc(Br)c(F)c1,benzene_ring
+12694,Please remove a amine from the molecule O=S(=O)(NCc1nnc2c3ccccc3c(-c3ccc(Cl)cc3)nn12)c1ccc(F)cc1.,O=S(=O)(NCc1nnc2c3ccccc3c(-c3ccc(Cl)cc3)nn12)c1ccc(F)cc1,amine
+207120,Please remove a halo from the molecule Cc1cccc(C(C)C)c1NC(=O)[C@H]1CC(=O)N(c2cc(F)cc(F)c2)C1.,Cc1cccc(C(C)C)c1NC(=O)[C@H]1CC(=O)N(c2cc(F)cc(F)c2)C1,halo
+63388,Modify the molecule [NH3+]C1CCC(n2cc(C(=O)NCc3nc(C4CCCCC4)no3)nn2)CC1 by removing a amide.,[NH3+]C1CCC(n2cc(C(=O)NCc3nc(C4CCCCC4)no3)nn2)CC1,amide
+219622,Remove a benzene_ring from the molecule Cc1nc(N2CCOCC2)cc(N2CCN(S(=O)(=O)c3ccc(F)cc3F)CC2)n1.,Cc1nc(N2CCOCC2)cc(N2CCN(S(=O)(=O)c3ccc(F)cc3F)CC2)n1,benzene_ring
+38105,Modify the molecule Cc1n[nH]c(C(=O)Nc2ccccc2N2CCCC2)n1 by removing a benzene_ring.,Cc1n[nH]c(C(=O)Nc2ccccc2N2CCCC2)n1,benzene_ring
+127268,Remove a amide from the molecule C[C@@H](NC(=O)C(=O)Nc1ccc(CC#N)cc1)c1ccc2c(c1)CCCC2.,C[C@@H](NC(=O)C(=O)Nc1ccc(CC#N)cc1)c1ccc2c(c1)CCCC2,amide
+179949,Modify the molecule CSCC[C@@H](C)NC(=O)N1CCN(c2ncccc2C#N)CC1 by removing a nitrile.,CSCC[C@@H](C)NC(=O)N1CCN(c2ncccc2C#N)CC1,nitrile
+154909,Remove a benzene_ring from the molecule O=C(CCS(=O)(=O)c1ccc2ccccc2c1)N1CCN(Cc2ccccc2F)CC1.,O=C(CCS(=O)(=O)c1ccc2ccccc2c1)N1CCN(Cc2ccccc2F)CC1,benzene_ring
+134180,Remove a amide from the molecule CCn1cc[nH+]c1CN1CCN(CC(=O)NC(=O)NC2CC2)CC1.,CCn1cc[nH+]c1CN1CCN(CC(=O)NC(=O)NC2CC2)CC1,amide
+148388,Modify the molecule Cc1ccc(N2C(=O)N[C@@H]3CCN(C(=O)CC4(CC(=O)[O-])CCCC4)[C@@H]3C2=O)cc1 by removing a benzene_ring.,Cc1ccc(N2C(=O)N[C@@H]3CCN(C(=O)CC4(CC(=O)[O-])CCCC4)[C@@H]3C2=O)cc1,benzene_ring
+141609,Remove a halo from the molecule Cc1c(O)n[nH]c1C(=O)NN=Cc1ccc(Cl)cc1Cl.,Cc1c(O)n[nH]c1C(=O)NN=Cc1ccc(Cl)cc1Cl,halo
+101320,Please remove a amide from the molecule O=C(CSc1nnc(Cc2cc(=O)[nH]c(=O)[nH]2)n1-c1ccc(Cl)cc1)Nc1ccccc1.,O=C(CSc1nnc(Cc2cc(=O)[nH]c(=O)[nH]2)n1-c1ccc(Cl)cc1)Nc1ccccc1,amide
+138918,Please remove a halo from the molecule N#Cc1cccc([N-]S(=O)(=O)c2ccc(-c3cc(C(F)(F)F)n[nH]3)s2)c1.,N#Cc1cccc([N-]S(=O)(=O)c2ccc(-c3cc(C(F)(F)F)n[nH]3)s2)c1,halo
+233423,Please remove a benzene_ring from the molecule COc1ccc(CCNC(=O)c2ccc(-c3nc4ccccc4n3C)s2)cc1OC.,COc1ccc(CCNC(=O)c2ccc(-c3nc4ccccc4n3C)s2)cc1OC,benzene_ring
+14405,Remove a benzene_ring from the molecule CSCCn1cnc(-c2cccc([N+](=O)[O-])c2)n1.,CSCCn1cnc(-c2cccc([N+](=O)[O-])c2)n1,benzene_ring
+17967,Modify the molecule Cc1ccc(-c2nnc(C[NH+]3CCC[C@H]3C[NH+]3CCC[C@@H]3CO)o2)cc1 by removing a hydroxyl.,Cc1ccc(-c2nnc(C[NH+]3CCC[C@H]3C[NH+]3CCC[C@@H]3CO)o2)cc1,hydroxyl
+144588,Please remove a amide from the molecule Cc1c(C#N)c(NC(=O)CN2C[C@@H](C(N)=O)Oc3ccccc32)n(Cc2ccco2)c1C.,Cc1c(C#N)c(NC(=O)CN2C[C@@H](C(N)=O)Oc3ccccc32)n(Cc2ccco2)c1C,amide
+22594,Remove a amide from the molecule Cc1cccc(O[C@@H](C)C(=O)N2CC[C@@H](C(=O)[O-])[C@@H]2C)c1.,Cc1cccc(O[C@@H](C)C(=O)N2CC[C@@H](C(=O)[O-])[C@@H]2C)c1,amide
+29621,Modify the molecule CN1C(=O)C[C@H](NC(=O)NCc2cccc(C#N)c2)[C@@H]1c1ccc(Cl)cc1 by removing a benzene_ring.,CN1C(=O)C[C@H](NC(=O)NCc2cccc(C#N)c2)[C@@H]1c1ccc(Cl)cc1,benzene_ring
+141561,Please remove a benzene_ring from the molecule CCN(Cc1ccccn1)c1ccc(F)cc1CC[NH3+].,CCN(Cc1ccccn1)c1ccc(F)cc1CC[NH3+],benzene_ring
+129575,Remove a benzene_ring from the molecule COc1ccc([C@H]2NC([S-])=NC3=C2[NH+]2CCC3CC2)cc1.,COc1ccc([C@H]2NC([S-])=NC3=C2[NH+]2CCC3CC2)cc1,benzene_ring
+186714,Remove a halo from the molecule CCc1cc(-c2ocnc2CCl)n(C)n1.,CCc1cc(-c2ocnc2CCl)n(C)n1,halo
+83534,Modify the molecule CC[C@@H](C)c1ccc(S(=O)(=O)NC[C@@H]2CC[NH+](C3CC3)C2)cc1 by removing a benzene_ring.,CC[C@@H](C)c1ccc(S(=O)(=O)NC[C@@H]2CC[NH+](C3CC3)C2)cc1,benzene_ring
+113995,Please remove a benzene_ring from the molecule CCc1ccccc1NCc1c(C(C)C)nn(C)c1N1CCOCC1.,CCc1ccccc1NCc1c(C(C)C)nn(C)c1N1CCOCC1,benzene_ring
+123992,Modify the molecule CC[NH+](CC)[C@H]1CCN([C@@H](C)C(=O)N[C@@H](C)c2ccc3c(c2)OCCO3)C1 by removing a amide.,CC[NH+](CC)[C@H]1CCN([C@@H](C)C(=O)N[C@@H](C)c2ccc3c(c2)OCCO3)C1,amide
+48960,Remove a amide from the molecule CC(C)c1nc(C(=O)Nc2ccc3c(c2)OCCO3)n[nH]1.,CC(C)c1nc(C(=O)Nc2ccc3c(c2)OCCO3)n[nH]1,amide
+28910,Remove a halo from the molecule O=C(NCc1nncn1C1CC1)Nc1cccc(Cl)c1F.,O=C(NCc1nncn1C1CC1)Nc1cccc(Cl)c1F,halo
+238904,Please remove a hydroxyl from the molecule CCCN(CCO)C(=O)N[C@H]1CCc2ccccc21.,CCCN(CCO)C(=O)N[C@H]1CCc2ccccc21,hydroxyl
+212301,Remove a amide from the molecule Cc1cc(NC(=O)[C@H](C)SCc2cccc3c2OCCO3)on1.,Cc1cc(NC(=O)[C@H](C)SCc2cccc3c2OCCO3)on1,amide
+101425,Remove a benzene_ring from the molecule CCOc1ccc(C2=CCN(C(=O)c3ccc(F)c(F)c3F)CC2)cc1.,CCOc1ccc(C2=CCN(C(=O)c3ccc(F)c(F)c3F)CC2)cc1,benzene_ring
+85342,Please remove a halo from the molecule Cc1cc(NC(=O)CC(C)C)c(C)cc1I.,Cc1cc(NC(=O)CC(C)C)c(C)cc1I,halo
+35114,Modify the molecule C/[NH+]=C(/NCc1cccc(F)c1)NCC(C)(C)N1C[C@H](C)O[C@H](C)C1 by removing a benzene_ring.,C/[NH+]=C(/NCc1cccc(F)c1)NCC(C)(C)N1C[C@H](C)O[C@H](C)C1,benzene_ring
+83042,Modify the molecule CC(C)(C)NC(=O)c1cccc(S(=O)(=O)[C@@H]2CCS(=O)(=O)C2)c1 by removing a benzene_ring.,CC(C)(C)NC(=O)c1cccc(S(=O)(=O)[C@@H]2CCS(=O)(=O)C2)c1,benzene_ring
+43220,Modify the molecule C=CCn1c([S-])nc2cc(C(=O)NCc3cccs3)ccc2c1=O by removing a amide.,C=CCn1c([S-])nc2cc(C(=O)NCc3cccs3)ccc2c1=O,amide
+50038,Please remove a hydroxyl from the molecule CC(=O)N[C@@H](Cc1cc(Br)c(O)c(Br)c1)C(=O)[O-].,CC(=O)N[C@@H](Cc1cc(Br)c(O)c(Br)c1)C(=O)[O-],hydroxyl
+144878,Modify the molecule C[C@@H]1CCN(C(=O)C(=O)Nc2ccnn2C(C)(C)C)C[C@H]1n1cc[nH+]c1 by removing a amide.,C[C@@H]1CCN(C(=O)C(=O)Nc2ccnn2C(C)(C)C)C[C@H]1n1cc[nH+]c1,amide
+202932,Modify the molecule Cc1nc2c(-c3cccs3)c(C)nn2c(NCC[NH+](C)C)c1C by removing a amine.,Cc1nc2c(-c3cccs3)c(C)nn2c(NCC[NH+](C)C)c1C,amine
+127024,Modify the molecule O=S(=O)(c1ccccc1F)N1CCN(CCn2cc[nH+]c2-c2ccccc2)CC1 by removing a benzene_ring.,O=S(=O)(c1ccccc1F)N1CCN(CCn2cc[nH+]c2-c2ccccc2)CC1,benzene_ring
+125253,Remove a halo from the molecule CCOC(=O)CCC(=O)c1ccccc1Cl.,CCOC(=O)CCC(=O)c1ccccc1Cl,halo
+59078,Remove a amide from the molecule C[C@H](C(N)=O)N1CCN(c2nccc(Oc3ccc(F)cc3)n2)CC1.,C[C@H](C(N)=O)N1CCN(c2nccc(Oc3ccc(F)cc3)n2)CC1,amide
+182793,Modify the molecule O=C(NC[C@H]1CCCO1)[C@H]1CC(c2ccc(Cl)c(Cl)c2)=NO1 by removing a halo.,O=C(NC[C@H]1CCCO1)[C@H]1CC(c2ccc(Cl)c(Cl)c2)=NO1,halo
+159495,Remove a amine from the molecule CC(C)(C)CC(C)(C)NC1=[NH+]CCN[C@H]1C(C)(C)C.,CC(C)(C)CC(C)(C)NC1=[NH+]CCN[C@H]1C(C)(C)C,amine
+43340,Remove a benzene_ring from the molecule CO[C@@H](C(=O)NCc1n[nH]c(=S)n1C(C)C)c1ccccc1.,CO[C@@H](C(=O)NCc1n[nH]c(=S)n1C(C)C)c1ccccc1,benzene_ring
+193497,Modify the molecule Cn1cccc1CN1CCc2c(Br)cccc2C1 by removing a halo.,Cn1cccc1CN1CCc2c(Br)cccc2C1,halo
+195963,Modify the molecule Cn1cc[nH+]c1C[C@@H]1CCCN(C(=O)C(=O)Nc2cccnc2Cl)C1 by removing a halo.,Cn1cc[nH+]c1C[C@@H]1CCCN(C(=O)C(=O)Nc2cccnc2Cl)C1,halo
+151264,Please remove a amide from the molecule Cn1c(CN2CCN(C(=O)C3CCCCC3)CC2)nc2cc(NC(=O)c3cccs3)ccc21.,Cn1c(CN2CCN(C(=O)C3CCCCC3)CC2)nc2cc(NC(=O)c3cccs3)ccc21,amide
+177256,Please remove a amine from the molecule C/C(=N\N)c1cccc(O)c1.,C/C(=N\N)c1cccc(O)c1,amine
+214575,Modify the molecule Cc1ccc(C)c(NC(=O)C(=O)NCC(C)(C)[C@@H](O)c2ccccc2)c1 by removing a hydroxyl.,Cc1ccc(C)c(NC(=O)C(=O)NCC(C)(C)[C@@H](O)c2ccccc2)c1,hydroxyl
+185813,Remove a amide from the molecule COc1ccc(C(=O)Nc2ccc(CC(=O)N(C)C)cc2)nn1.,COc1ccc(C(=O)Nc2ccc(CC(=O)N(C)C)cc2)nn1,amide
+198029,Modify the molecule Cc1noc(CCCNC(=O)N[C@@H](c2ccccc2)c2ccco2)n1 by removing a benzene_ring.,Cc1noc(CCCNC(=O)N[C@@H](c2ccccc2)c2ccco2)n1,benzene_ring
+168007,Remove a benzene_ring from the molecule COc1ccccc1C[C@@H](C)N(C)C(=O)[C@H](C)NC(C)=O.,COc1ccccc1C[C@@H](C)N(C)C(=O)[C@H](C)NC(C)=O,benzene_ring
+174889,Modify the molecule CSC[C@@](C)(O)CNC(=O)c1cc(-c2ccccc2)on1 by removing a amide.,CSC[C@@](C)(O)CNC(=O)c1cc(-c2ccccc2)on1,amide
+134808,Please remove a halo from the molecule C[C@@H](CO)NC(=O)NC[C@H](C)Oc1ccc(F)cc1.,C[C@@H](CO)NC(=O)NC[C@H](C)Oc1ccc(F)cc1,halo
+184467,Remove a benzene_ring from the molecule COc1cccc(-n2nnc(-c3nc(-c4ccccc4F)no3)c2C)c1.,COc1cccc(-n2nnc(-c3nc(-c4ccccc4F)no3)c2C)c1,benzene_ring
+230342,Remove a amide from the molecule Cc1cc(C)cc(C(=O)N[C@@H](CCc2ccccc2)c2ccc3c(c2)OCCCO3)c1.,Cc1cc(C)cc(C(=O)N[C@@H](CCc2ccccc2)c2ccc3c(c2)OCCCO3)c1,amide
+27014,Modify the molecule C[C@H](OC(=O)[C@H](C)N1C(=O)c2ccccc2C1=O)C(=O)c1ccc(F)c(F)c1 by removing a benzene_ring.,C[C@H](OC(=O)[C@H](C)N1C(=O)c2ccccc2C1=O)C(=O)c1ccc(F)c(F)c1,benzene_ring
+103798,Remove a amide from the molecule CC(C)C(=O)Nc1c(-c2cccs2)nc2ccccn12.,CC(C)C(=O)Nc1c(-c2cccs2)nc2ccccn12,amide
+151247,Please remove a halo from the molecule COc1ccc(Cl)c(NC(=O)c2csc(C#CCN)c2)c1.,COc1ccc(Cl)c(NC(=O)c2csc(C#CCN)c2)c1,halo
+96067,Remove a halo from the molecule COc1cc(Br)c([C@H]2CC(=O)NC3=C2C(=O)C[C@@H](c2ccc(C)cc2)C3)cc1OC.,COc1cc(Br)c([C@H]2CC(=O)NC3=C2C(=O)C[C@@H](c2ccc(C)cc2)C3)cc1OC,halo
+89904,Remove a amide from the molecule CCCCOc1ccc(C(=O)Nc2[nH]nc(C)c2N)cc1.,CCCCOc1ccc(C(=O)Nc2[nH]nc(C)c2N)cc1,amide
+226968,Remove a benzene_ring from the molecule COC(=O)c1c(NC(=O)c2ccc(F)cc2)sc(C(=O)N[C@H](C)c2ccccc2)c1C.,COC(=O)c1c(NC(=O)c2ccc(F)cc2)sc(C(=O)N[C@H](C)c2ccccc2)c1C,benzene_ring
+161024,Modify the molecule O=C([O-])[C@H]1CC(=O)N(CCN2C[C@H](C(=O)[O-])CC2=O)C1 by removing a amide.,O=C([O-])[C@H]1CC(=O)N(CCN2C[C@H](C(=O)[O-])CC2=O)C1,amide
+190473,Remove a halo from the molecule CC(C)C[C@H](NC(N)=O)C(=O)N1CCc2ccc(Cl)cc2C1.,CC(C)C[C@H](NC(N)=O)C(=O)N1CCc2ccc(Cl)cc2C1,halo
+47748,Please remove a amide from the molecule COc1ccc2nc(NC(=O)CN(C)S(=O)(=O)c3cccs3)sc2c1.,COc1ccc2nc(NC(=O)CN(C)S(=O)(=O)c3cccs3)sc2c1,amide
+198441,Remove a benzene_ring from the molecule C/C(Cc1ccccc1)=N\NC(=O)CNC(=O)c1cccnc1.,C/C(Cc1ccccc1)=N\NC(=O)CNC(=O)c1cccnc1,benzene_ring
+175739,Please remove a halo from the molecule CN(CCCN1CC[NH+](C)CC1)C(=O)C1(c2ccc(Cl)cc2)CC1.,CN(CCCN1CC[NH+](C)CC1)C(=O)C1(c2ccc(Cl)cc2)CC1,halo
+135873,Please remove a benzene_ring from the molecule C[C@@H]1CCN(C(=O)COC/C=C/c2ccccc2)C[C@H]1O.,C[C@@H]1CCN(C(=O)COC/C=C/c2ccccc2)C[C@H]1O,benzene_ring
+156041,Please remove a amine from the molecule Cc1cc(C)n(-c2ncnc(N3C[C@@]4(C)C[C@@H]3CC(C)(C)C4)c2N)n1.,Cc1cc(C)n(-c2ncnc(N3C[C@@]4(C)C[C@@H]3CC(C)(C)C4)c2N)n1,amine
+222433,Please remove a benzene_ring from the molecule CCC12c3ccccc3C(c3ccccc31)[C@@H]1C(=O)N(c3cc(C(C)=O)ccc3OC)C(=O)[C@@H]12.,CCC12c3ccccc3C(c3ccccc31)[C@@H]1C(=O)N(c3cc(C(C)=O)ccc3OC)C(=O)[C@@H]12,benzene_ring
+136751,Please remove a benzene_ring from the molecule COc1cc([C@H]2[NH2+]CCc3c2[nH]c2ccccc32)cc(OC)c1OC.,COc1cc([C@H]2[NH2+]CCc3c2[nH]c2ccccc32)cc(OC)c1OC,benzene_ring
+165548,Please remove a benzene_ring from the molecule O=C(Oc1ccc(-n2cnnn2)cc1)c1cccc(N2CCCC2=O)c1.,O=C(Oc1ccc(-n2cnnn2)cc1)c1cccc(N2CCCC2=O)c1,benzene_ring
+58020,Remove a halo from the molecule COc1ccc([C@H]([NH2+][C@@H](C)c2ccc(OC)cc2F)C2CCOCC2)cc1.,COc1ccc([C@H]([NH2+][C@@H](C)c2ccc(OC)cc2F)C2CCOCC2)cc1,halo
+81235,Remove a amide from the molecule CC(C)[C@@H]1CN(C(=O)Cc2ccsc2)C[C@H]1C(=O)[O-].,CC(C)[C@@H]1CN(C(=O)Cc2ccsc2)C[C@H]1C(=O)[O-],amide
+242442,Please remove a nitrile from the molecule CC(C)(CNC(=O)C(=O)Nc1nn(C(C)(C)C)cc1C#N)C1CCCC1.,CC(C)(CNC(=O)C(=O)Nc1nn(C(C)(C)C)cc1C#N)C1CCCC1,nitrile
+144255,Please remove a amide from the molecule O=C(N/N=C/c1ccc(N2CCCCCC2)o1)c1cc2ccccc2o1.,O=C(N/N=C/c1ccc(N2CCCCCC2)o1)c1cc2ccccc2o1,amide
+24665,Please remove a benzene_ring from the molecule Cc1cc(CN[C@@H](C)C#N)cc(C)c1F.,Cc1cc(CN[C@@H](C)C#N)cc(C)c1F,benzene_ring
+116233,Remove a benzene_ring from the molecule C[C@@H](c1cccc(O)c1)[NH+](C)C[C@@H]1C[C@@H]1c1ccccc1.,C[C@@H](c1cccc(O)c1)[NH+](C)C[C@@H]1C[C@@H]1c1ccccc1,benzene_ring
+115504,Please remove a amine from the molecule Cc1ccc(S(=O)(=O)NCCc2csc3nc(-c4cccs4)nn23)cc1C.,Cc1ccc(S(=O)(=O)NCCc2csc3nc(-c4cccs4)nn23)cc1C,amine
+136296,Remove a amide from the molecule COCc1nnc(NC(=O)c2cc(=O)c(OCc3ccccc3)co2)s1.,COCc1nnc(NC(=O)c2cc(=O)c(OCc3ccccc3)co2)s1,amide
+248870,Modify the molecule O=c1c(C[NH+]2CCN(c3ccccc3F)CC2)coc2ccc(Cl)cc12 by removing a benzene_ring.,O=c1c(C[NH+]2CCN(c3ccccc3F)CC2)coc2ccc(Cl)cc12,benzene_ring
+137537,Modify the molecule CCn1c(=O)c(C(=O)NC(C)C)nc2cc(C)c(C)cc21 by removing a amide.,CCn1c(=O)c(C(=O)NC(C)C)nc2cc(C)c(C)cc21,amide
+77662,Remove a nitro from the molecule O=C1OCC[C@H]1N1CCc2ccc([N+](=O)[O-])cc2C1.,O=C1OCC[C@H]1N1CCc2ccc([N+](=O)[O-])cc2C1,nitro
+2030,Remove a amide from the molecule O=C(COc1ccccn1)NCc1ccc(F)cc1.,O=C(COc1ccccn1)NCc1ccc(F)cc1,amide
+170322,Remove a benzene_ring from the molecule CN(CCC#N)C(=O)c1cnn(Cc2ccccc2)c1.,CN(CCC#N)C(=O)c1cnn(Cc2ccccc2)c1,benzene_ring
+195330,Modify the molecule COc1ccc([C@H]2C(C(=O)Nc3ccccc3)=C(C)Nc3nnnn32)cc1 by removing a benzene_ring.,COc1ccc([C@H]2C(C(=O)Nc3ccccc3)=C(C)Nc3nnnn32)cc1,benzene_ring
+6884,Please remove a benzene_ring from the molecule COc1c(NC(=O)Nc2cccc(NC(C)=O)c2C)c(C)nn1C.,COc1c(NC(=O)Nc2cccc(NC(C)=O)c2C)c(C)nn1C,benzene_ring
+226995,Please remove a benzene_ring from the molecule Cc1ccccc1-n1ncc2c1CC(C)(C)C[C@@H]2[NH2+]Cc1ccc(C#CC(C)(C)O)cc1.,Cc1ccccc1-n1ncc2c1CC(C)(C)C[C@@H]2[NH2+]Cc1ccc(C#CC(C)(C)O)cc1,benzene_ring
+44757,Remove a benzene_ring from the molecule Cc1ccc(S[C@H]2CCC[C@@]([NH3+])(CO)C2)c(C)c1.,Cc1ccc(S[C@H]2CCC[C@@]([NH3+])(CO)C2)c(C)c1,benzene_ring
+202890,Please remove a amide from the molecule C[C@@H](NC(=O)c1ccccc1NC(=O)OCc1ccccc1)c1ccccc1.,C[C@@H](NC(=O)c1ccccc1NC(=O)OCc1ccccc1)c1ccccc1,amide
+145203,Remove a hydroxyl from the molecule C[C@H]1COC[C@@H](C)N1C(=O)c1cc(Cl)c2ccccc2c1O.,C[C@H]1COC[C@@H](C)N1C(=O)c1cc(Cl)c2ccccc2c1O,hydroxyl
+25039,Please remove a nitrile from the molecule CCc1ccccc1NC(=O)CSC1=C(C#N)[C@@H](c2ccc3c(c2)OCO3)[C@H]2C(=O)CCCC2=N1.,CCc1ccccc1NC(=O)CSC1=C(C#N)[C@@H](c2ccc3c(c2)OCO3)[C@H]2C(=O)CCCC2=N1,nitrile
+2907,Remove a amine from the molecule CC(C)NS(=O)(=O)c1ccc(NC(=O)CCC2CCCC2)cc1.,CC(C)NS(=O)(=O)c1ccc(NC(=O)CCC2CCCC2)cc1,amine
+120556,Remove a benzene_ring from the molecule O=C(c1cnns1)N1CCC[C@@H]1c1cccc(Br)c1.,O=C(c1cnns1)N1CCC[C@@H]1c1cccc(Br)c1,benzene_ring
+197490,Remove a amide from the molecule Cc1[nH+]ccn1CCNC(=O)C1(Cc2cccc([C@H]3CCC[NH+](C)C3)c2)CCOCC1.,Cc1[nH+]ccn1CCNC(=O)C1(Cc2cccc([C@H]3CCC[NH+](C)C3)c2)CCOCC1,amide
+103407,Remove a benzene_ring from the molecule Cc1cccc(C)c1NC(=O)CS[C@H](C)c1cc(F)ccc1F.,Cc1cccc(C)c1NC(=O)CS[C@H](C)c1cc(F)ccc1F,benzene_ring
+60307,Remove a halo from the molecule C[C@@H](Cc1ccsc1)N(C)C(=O)NCc1ccc(Br)cc1.,C[C@@H](Cc1ccsc1)N(C)C(=O)NCc1ccc(Br)cc1,halo
+6972,Remove a benzene_ring from the molecule C[C@@H]1C[NH+](CCOc2ccc(CC[NH3+])cc2)C[C@@H]1C.,C[C@@H]1C[NH+](CCOc2ccc(CC[NH3+])cc2)C[C@@H]1C,benzene_ring
+33675,Please remove a amine from the molecule O=C(CS[C@H]1NN=C(c2cccs2)O1)C1=CC(C(=O)N2CCCC2)=NC1.,O=C(CS[C@H]1NN=C(c2cccs2)O1)C1=CC(C(=O)N2CCCC2)=NC1,amine
+113655,Please remove a halo from the molecule O=C(NCc1ccnc(OCC(F)F)c1)NC1CCCCCC1.,O=C(NCc1ccnc(OCC(F)F)c1)NC1CCCCCC1,halo
+105227,Remove a amide from the molecule CCOc1ccc(S(=O)(=O)N2CCC[C@@H](CNC(C)=O)C2)c2ccccc12.,CCOc1ccc(S(=O)(=O)N2CCC[C@@H](CNC(C)=O)C2)c2ccccc12,amide
+147992,Remove a amide from the molecule Cc1cc(C(=O)NCC2CCN(S(=O)(=O)C3CC3)CC2)no1.,Cc1cc(C(=O)NCC2CCN(S(=O)(=O)C3CC3)CC2)no1,amide
+41402,Remove a benzene_ring from the molecule COc1cccc(SCC(=O)Nc2ccc(C(=O)N(C)C)cc2)c1.,COc1cccc(SCC(=O)Nc2ccc(C(=O)N(C)C)cc2)c1,benzene_ring
+40936,Modify the molecule COc1ncccc1CNC(=O)CCC1CCCC1 by removing a amide.,COc1ncccc1CNC(=O)CCC1CCCC1,amide
+11086,Remove a amide from the molecule C#CCNC(=O)c1cc(OC)c(OC)cc1NC(=O)c1ccccc1.,C#CCNC(=O)c1cc(OC)c(OC)cc1NC(=O)c1ccccc1,amide
+225146,Modify the molecule Cc1c(C(=O)Nc2ccc3c(c2)OCCO3)sc2ncn(Cc3ccccc3F)c(=O)c12 by removing a amide.,Cc1c(C(=O)Nc2ccc3c(c2)OCCO3)sc2ncn(Cc3ccccc3F)c(=O)c12,amide
+141356,Remove a amide from the molecule C/C(=N\NC(=O)[C@H](C)Oc1ccc(Cl)cc1)c1ccccc1.,C/C(=N\NC(=O)[C@H](C)Oc1ccc(Cl)cc1)c1ccccc1,amide
+176311,Remove a amide from the molecule COCC(=O)N(CCC(N)=O)c1ccccc1.,COCC(=O)N(CCC(N)=O)c1ccccc1,amide
+186870,Remove a benzene_ring from the molecule C=CCn1/c(=N\C(=O)Cc2ccc(S(=O)(=O)CC)cc2)sc2cc3c(cc21)OCO3.,C=CCn1/c(=N\C(=O)Cc2ccc(S(=O)(=O)CC)cc2)sc2cc3c(cc21)OCO3,benzene_ring
+152851,Remove a amide from the molecule COc1ccc2c(c1)[C@H]([NH2+]C[C@@H]1CCC(=O)N1)CCC2.,COc1ccc2c(c1)[C@H]([NH2+]C[C@@H]1CCC(=O)N1)CCC2,amide
+169978,Modify the molecule CN(C(=O)NCc1cccc(OCc2ccccc2)c1)C1CCS(=O)CC1 by removing a benzene_ring.,CN(C(=O)NCc1cccc(OCc2ccccc2)c1)C1CCS(=O)CC1,benzene_ring
+80021,Modify the molecule CC1(C)CN(C(=O)c2cccc(-n3cccn3)c2)CC[S@]1=O by removing a amide.,CC1(C)CN(C(=O)c2cccc(-n3cccn3)c2)CC[S@]1=O,amide
+178182,Modify the molecule Cn1c(=C(C#N)C#N)s/c(=C/c2ccc(F)cc2)c1=O by removing a halo.,Cn1c(=C(C#N)C#N)s/c(=C/c2ccc(F)cc2)c1=O,halo
+89380,Please remove a amide from the molecule O=C(CCNC(=O)N[C@@H]1CCCC[C@@H]1CO)NC1CCCC1.,O=C(CCNC(=O)N[C@@H]1CCCC[C@@H]1CO)NC1CCCC1,amide
+200159,Modify the molecule N/C(=N/c1ccccc1)S[C@@H]1CC(=O)N(c2ccc(F)cc2)C1=O by removing a benzene_ring.,N/C(=N/c1ccccc1)S[C@@H]1CC(=O)N(c2ccc(F)cc2)C1=O,benzene_ring
+22973,Remove a halo from the molecule Cn1cnc(Cl)c1Cl.,Cn1cnc(Cl)c1Cl,halo
+90349,Modify the molecule CCOCCOc1cccc(C[NH2+]C)c1 by removing a benzene_ring.,CCOCCOc1cccc(C[NH2+]C)c1,benzene_ring
+70812,Modify the molecule CC[NH+]1CC[C@H](N(C)CC(=O)NC(=O)Nc2ccc(C)c(C)c2)[C@H](C)C1 by removing a benzene_ring.,CC[NH+]1CC[C@H](N(C)CC(=O)NC(=O)Nc2ccc(C)c(C)c2)[C@H](C)C1,benzene_ring
+22664,Please remove a benzene_ring from the molecule CCN(CC(C)(C)O)C(=O)Cc1ccc(C[NH3+])cc1.,CCN(CC(C)(C)O)C(=O)Cc1ccc(C[NH3+])cc1,benzene_ring
+108102,Please remove a amide from the molecule Cc1csc(CN(C)C(=O)C=C2CCSCC2)n1.,Cc1csc(CN(C)C(=O)C=C2CCSCC2)n1,amide
+188740,Remove a halo from the molecule O=C(c1ccc(Br)cc1F)c1ccccc1C[N+]1=CCCC1.,O=C(c1ccc(Br)cc1F)c1ccccc1C[N+]1=CCCC1,halo
+112978,Please remove a benzene_ring from the molecule C[C@@H]([NH3+])c1cc(F)ccc1OC[C@@H]1Cc2ccccc2S1.,C[C@@H]([NH3+])c1cc(F)ccc1OC[C@@H]1Cc2ccccc2S1,benzene_ring
+210784,Modify the molecule Cn1cc(C[NH+](C)Cc2ccccc2-c2ccccc2)c(=O)n(C)c1=O by removing a benzene_ring.,Cn1cc(C[NH+](C)Cc2ccccc2-c2ccccc2)c(=O)n(C)c1=O,benzene_ring
+89410,Please remove a amide from the molecule CC(=O)N[C@@H](C(=O)O[C@H](C)c1nc(C)no1)C1CCCC1.,CC(=O)N[C@@H](C(=O)O[C@H](C)c1nc(C)no1)C1CCCC1,amide
+198023,Modify the molecule Cc1ccc(NC(=O)NCCn2ncnn2)cc1 by removing a benzene_ring.,Cc1ccc(NC(=O)NCCn2ncnn2)cc1,benzene_ring
+113570,Remove a amine from the molecule N#Cc1cnc(S[C@@H](C(=O)Nc2ccccc2)c2ccccc2)nc1N.,N#Cc1cnc(S[C@@H](C(=O)Nc2ccccc2)c2ccccc2)nc1N,amine
+241793,Please remove a amide from the molecule CCc1nn(C)cc1NC(=O)c1cnc2onc(C)c2c1.,CCc1nn(C)cc1NC(=O)c1cnc2onc(C)c2c1,amide
+63634,Modify the molecule C[C@@H](NC(=O)NC[C@@H]1CCO[C@@H]1C(C)(C)C)[C@H](C)c1ccccc1 by removing a benzene_ring.,C[C@@H](NC(=O)NC[C@@H]1CCO[C@@H]1C(C)(C)C)[C@H](C)c1ccccc1,benzene_ring
+188777,Remove a benzene_ring from the molecule Cc1c(C(=O)OCc2cccc(Cl)c2)oc2ccccc12.,Cc1c(C(=O)OCc2cccc(Cl)c2)oc2ccccc12,benzene_ring
+14535,Remove a amide from the molecule O=C(Nc1ccc(F)cc1)c1cccc(-n2cnnc2)n1.,O=C(Nc1ccc(F)cc1)c1cccc(-n2cnnc2)n1,amide
+238638,Remove a benzene_ring from the molecule O=S1(=O)C[C@@H]2[C@@H](C1)N(c1cccc3ccccc13)C(=S)N2c1ccccc1.,O=S1(=O)C[C@@H]2[C@@H](C1)N(c1cccc3ccccc13)C(=S)N2c1ccccc1,benzene_ring
+216966,Remove a benzene_ring from the molecule CCc1nn(C)c(C(=O)N/N=C/c2ccccc2)c1Cl.,CCc1nn(C)c(C(=O)N/N=C/c2ccccc2)c1Cl,benzene_ring
+206095,Modify the molecule O[C@H](CN1CC[NH+](C/C=C/c2ccccc2)CC1)c1ccc(Cl)cc1 by removing a hydroxyl.,O[C@H](CN1CC[NH+](C/C=C/c2ccccc2)CC1)c1ccc(Cl)cc1,hydroxyl
+31450,Modify the molecule CCN(c1ccccc1)S(=O)(=O)c1ccc(C(=O)Nc2ccc(Cl)cc2)cc1 by removing a benzene_ring.,CCN(c1ccccc1)S(=O)(=O)c1ccc(C(=O)Nc2ccc(Cl)cc2)cc1,benzene_ring
+35177,Remove a amide from the molecule O=C(CC[C@@H]1NC(=O)NC1=O)NCc1cn2cc(Cl)ccc2n1.,O=C(CC[C@@H]1NC(=O)NC1=O)NCc1cn2cc(Cl)ccc2n1,amide
+192837,Please remove a amide from the molecule CCCNC(=O)CNC(=O)c1cccs1.,CCCNC(=O)CNC(=O)c1cccs1,amide
+158221,Please remove a benzene_ring from the molecule C[C@H]([NH2+]Cc1ccc(-n2ccnc2)cc1)c1ccco1.,C[C@H]([NH2+]Cc1ccc(-n2ccnc2)cc1)c1ccco1,benzene_ring
+110935,Modify the molecule Cc1nc2cc(NS(=O)(=O)c3cccc(C#N)c3)ccc2o1 by removing a benzene_ring.,Cc1nc2cc(NS(=O)(=O)c3cccc(C#N)c3)ccc2o1,benzene_ring
+36403,Modify the molecule CC[C@H](C)CNS(=O)(=O)c1cc([N+](=O)[O-])c(F)cc1C by removing a nitro.,CC[C@H](C)CNS(=O)(=O)c1cc([N+](=O)[O-])c(F)cc1C,nitro
+107663,Please remove a amide from the molecule NC(=O)NCc1ccc(C(=O)N(CC2CC2)c2ccccc2)cc1.,NC(=O)NCc1ccc(C(=O)N(CC2CC2)c2ccccc2)cc1,amide
+243485,Remove a amide from the molecule O=C(NCc1ccccn1)[C@@H]1CCCN1C(=O)C12CC3CC(CC(C3)C1)C2.,O=C(NCc1ccccn1)[C@@H]1CCCN1C(=O)C12CC3CC(CC(C3)C1)C2,amide
+234268,Remove a amide from the molecule CC(C)CNc1nc2ccccn2c(=O)c1/C=C1\SC(=S)N(C[C@H]2CCCO2)C1=O.,CC(C)CNc1nc2ccccn2c(=O)c1/C=C1\SC(=S)N(C[C@H]2CCCO2)C1=O,amide
+143595,Please remove a amide from the molecule C[C@H](c1ccccc1)N1C[C@@H](c2nc3ccccc3n2CC(=O)N2CCOCC2)CC1=O.,C[C@H](c1ccccc1)N1C[C@@H](c2nc3ccccc3n2CC(=O)N2CCOCC2)CC1=O,amide
+119866,Remove a amide from the molecule NC(=O)CCCOC(=O)c1ccc(F)c(Br)c1.,NC(=O)CCCOC(=O)c1ccc(F)c(Br)c1,amide
+161939,Modify the molecule Cc1cc(C)cc(Nc2nc(C)cc3nn(CC(=O)NCc4ccco4)c(=O)n23)c1 by removing a benzene_ring.,Cc1cc(C)cc(Nc2nc(C)cc3nn(CC(=O)NCc4ccco4)c(=O)n23)c1,benzene_ring
+12215,Remove a halo from the molecule COC(=O)C[C@H](C)S[C@H]1CCN(c2c(F)cccc2F)C1=O.,COC(=O)C[C@H](C)S[C@H]1CCN(c2c(F)cccc2F)C1=O,halo
+229805,Modify the molecule COc1ccccc1CNC(=O)[C@H](C)Sc1nnc(-c2c[nH]c3ccccc23)o1 by removing a benzene_ring.,COc1ccccc1CNC(=O)[C@H](C)Sc1nnc(-c2c[nH]c3ccccc23)o1,benzene_ring
+145517,Please remove a benzene_ring from the molecule Cc1ccccc1-c1c(C2C(C)(C)C2(C)C)noc1N.,Cc1ccccc1-c1c(C2C(C)(C)C2(C)C)noc1N,benzene_ring
+132169,Remove a benzene_ring from the molecule O=C(Nc1ccc(-c2ncon2)cc1)c1cccc(Br)n1.,O=C(Nc1ccc(-c2ncon2)cc1)c1cccc(Br)n1,benzene_ring
+137146,Modify the molecule O=C(/C=C/c1ccc2c(c1)CCO2)N1CCC[C@@H]1c1nnc2ccccn12 by removing a amide.,O=C(/C=C/c1ccc2c(c1)CCO2)N1CCC[C@@H]1c1nnc2ccccn12,amide
+128950,Remove a amine from the molecule CCc1ccc([C@H](C)NC(=O)CSc2nnc(-n3nc(C)cc3C)n2N)cc1.,CCc1ccc([C@H](C)NC(=O)CSc2nnc(-n3nc(C)cc3C)n2N)cc1,amine
+136008,Please remove a amide from the molecule CCCC(=O)N1CSC[C@H]1C(=O)N[C@@H](CC)c1c(C)nn(C)c1C.,CCCC(=O)N1CSC[C@H]1C(=O)N[C@@H](CC)c1c(C)nn(C)c1C,amide
+157647,Modify the molecule Cc1ccc(NC(=O)[C@H](C)Sc2ncn[nH]2)c(C)c1 by removing a amide.,Cc1ccc(NC(=O)[C@H](C)Sc2ncn[nH]2)c(C)c1,amide
+70839,Please remove a amine from the molecule C[C@H](Nc1nc2nonc2nc1NCc1ccccc1)c1nccs1.,C[C@H](Nc1nc2nonc2nc1NCc1ccccc1)c1nccs1,amine
+192971,Modify the molecule COc1cc(C)c(N)cc1S(=O)(=O)N[C@H](C)CCC(C)C by removing a benzene_ring.,COc1cc(C)c(N)cc1S(=O)(=O)N[C@H](C)CCC(C)C,benzene_ring
+102826,Modify the molecule CCC[NH2+][C@@H](COC)C1(c2ccccc2)CCCC1 by removing a benzene_ring.,CCC[NH2+][C@@H](COC)C1(c2ccccc2)CCCC1,benzene_ring
+116941,Remove a nitrile from the molecule COC(=O)CN(CC#N)S(=O)(=O)c1cc(C)c(C)s1.,COC(=O)CN(CC#N)S(=O)(=O)c1cc(C)c(C)s1,nitrile
+166967,Modify the molecule CC[C@](C)(NS(=O)(=O)c1ccc(OC)c(F)c1)C(=O)[O-] by removing a amine.,CC[C@](C)(NS(=O)(=O)c1ccc(OC)c(F)c1)C(=O)[O-],amine
+123568,Modify the molecule COC(=O)CCN(CC(C)C)C(=O)c1ccc(Cl)nc1Cl by removing a amide.,COC(=O)CCN(CC(C)C)C(=O)c1ccc(Cl)nc1Cl,amide
+176440,Remove a amide from the molecule C[C@@H](C(=O)N[C@H](CC(N)=O)C1CCCCC1)n1nnc(-c2ccccc2)n1.,C[C@@H](C(=O)N[C@H](CC(N)=O)C1CCCCC1)n1nnc(-c2ccccc2)n1,amide
+45324,Please remove a benzene_ring from the molecule N#CCC(=O)c1ccc(F)cc1F.,N#CCC(=O)c1ccc(F)cc1F,benzene_ring
+29489,Remove a benzene_ring from the molecule CN(C)[C@@H]1CCC[NH+](C[C@@H]2C[C@@H]2c2ccccc2)C1.,CN(C)[C@@H]1CCC[NH+](C[C@@H]2C[C@@H]2c2ccccc2)C1,benzene_ring
+216602,Modify the molecule CC(=C/c1ccccc1)/C=C1/N=C(c2cccc([N+](=O)[O-])c2)OC1=O by removing a benzene_ring.,CC(=C/c1ccccc1)/C=C1/N=C(c2cccc([N+](=O)[O-])c2)OC1=O,benzene_ring
+106068,Remove a benzene_ring from the molecule CC[NH+](CC)CCNC(=O)N(C)Cc1ccccc1C.,CC[NH+](CC)CCNC(=O)N(C)Cc1ccccc1C,benzene_ring
+153151,Remove a amine from the molecule Cc1noc(C)c1S(=O)(=O)NCCn1nc(-n2ccnc2)ccc1=O.,Cc1noc(C)c1S(=O)(=O)NCCn1nc(-n2ccnc2)ccc1=O,amine
+78104,Please remove a amide from the molecule C=CCNC(=O)NC(=O)[C@H](C)N1CC[NH+](CC2CC2)CC1.,C=CCNC(=O)NC(=O)[C@H](C)N1CC[NH+](CC2CC2)CC1,amide
+43647,Modify the molecule CCc1ccc([C@H](CO)NC(=O)[C@H]2CCCN2C(C)=O)cc1 by removing a benzene_ring.,CCc1ccc([C@H](CO)NC(=O)[C@H]2CCCN2C(C)=O)cc1,benzene_ring
+63925,Modify the molecule C[C@](Nc1ncc([N+](=O)[O-])cc1Br)(C(=O)[O-])C1CC1 by removing a nitro.,C[C@](Nc1ncc([N+](=O)[O-])cc1Br)(C(=O)[O-])C1CC1,nitro
+94272,Please remove a benzene_ring from the molecule CC(C)(C)c1ccc(C(=O)N2CCN(c3c(Cl)cccc3NC(N)=S)CC2)cc1.,CC(C)(C)c1ccc(C(=O)N2CCN(c3c(Cl)cccc3NC(N)=S)CC2)cc1,benzene_ring
+110774,Modify the molecule CCc1nn(C)cc1C(=O)N[C@@H](CC)c1ccccc1O by removing a amide.,CCc1nn(C)cc1C(=O)N[C@@H](CC)c1ccccc1O,amide
+40867,Modify the molecule O=C(CCSc1ccccc1)N1CCC[C@@H](c2nnc3ccc(C(F)(F)F)cn23)C1 by removing a amide.,O=C(CCSc1ccccc1)N1CCC[C@@H](c2nnc3ccc(C(F)(F)F)cn23)C1,amide
+248001,Please remove a amide from the molecule Cc1cccc(C(=O)NCCn2nc(-c3cccnc3)ccc2=O)c1.,Cc1cccc(C(=O)NCCn2nc(-c3cccnc3)ccc2=O)c1,amide
+213838,Modify the molecule CC[C@H](c1ccc(F)cc1F)[NH+]1CCC[C@H](C(=O)Nc2ncccc2C)C1 by removing a amide.,CC[C@H](c1ccc(F)cc1F)[NH+]1CCC[C@H](C(=O)Nc2ncccc2C)C1,amide
+84817,Remove a halo from the molecule O=C(CSc1nnc(NC(=O)c2ccccc2)s1)NCc1ccc(F)cc1.,O=C(CSc1nnc(NC(=O)c2ccccc2)s1)NCc1ccc(F)cc1,halo
+106308,Modify the molecule CCc1noc(CC)c1CC(=O)Nc1ncc(C)s1 by removing a amide.,CCc1noc(CC)c1CC(=O)Nc1ncc(C)s1,amide
+170332,Modify the molecule O=[N+]([O-])c1ccc(CSc2nc(-c3ccccc3)c[nH]2)cc1 by removing a benzene_ring.,O=[N+]([O-])c1ccc(CSc2nc(-c3ccccc3)c[nH]2)cc1,benzene_ring
+128122,Remove a halo from the molecule CC1(C)[C@@H](NC(=O)c2ccc(Cl)c3cccnc23)[C@@H]2CCO[C@@H]21.,CC1(C)[C@@H](NC(=O)c2ccc(Cl)c3cccnc23)[C@@H]2CCO[C@@H]21,halo
+121901,Modify the molecule COc1ccc2c(CN3CCN(C(=O)[C@@H]4C[C@@H]4C)CC3)cc(=O)oc2c1 by removing a amide.,COc1ccc2c(CN3CCN(C(=O)[C@@H]4C[C@@H]4C)CC3)cc(=O)oc2c1,amide
+177098,Please remove a amide from the molecule CC(C)N(C)C(=O)[C@H](C)SCc1ccnn1C.,CC(C)N(C)C(=O)[C@H](C)SCc1ccnn1C,amide
+146119,Remove a amide from the molecule CC(C)(C)OC(=O)N1CCC[C@H]1CCC(=O)NNc1cccnc1Cl.,CC(C)(C)OC(=O)N1CCC[C@H]1CCC(=O)NNc1cccnc1Cl,amide
+192843,Please remove a benzene_ring from the molecule Cc1ccc(S(=O)(=O)N2CCCCC2)cc1NC(=O)N[C@H](C)C(C)C.,Cc1ccc(S(=O)(=O)N2CCCCC2)cc1NC(=O)N[C@H](C)C(C)C,benzene_ring
+63840,Please remove a benzene_ring from the molecule CNC(=O)[C@H](CC(C)C)NS(=O)(=O)c1ccc(F)cc1C.,CNC(=O)[C@H](CC(C)C)NS(=O)(=O)c1ccc(F)cc1C,benzene_ring
+10942,Please remove a amide from the molecule CC1(C)C(=O)NC(=O)CN1Cc1cccc(N)[nH+]1.,CC1(C)C(=O)NC(=O)CN1Cc1cccc(N)[nH+]1,amide
+138562,Modify the molecule Cc1cc(Oc2ccc(C#N)cc2)ccc1NC(=O)N1CCc2ccccc2C1 by removing a benzene_ring.,Cc1cc(Oc2ccc(C#N)cc2)ccc1NC(=O)N1CCc2ccccc2C1,benzene_ring
+244054,Modify the molecule Cc1ccc(C(C)C)c(OCC(=O)Nc2nc(C[NH+]3CCCCC3)cs2)c1 by removing a benzene_ring.,Cc1ccc(C(C)C)c(OCC(=O)Nc2nc(C[NH+]3CCCCC3)cs2)c1,benzene_ring
+200932,Modify the molecule Cc1nn(CC(=O)N[C@H]2C[C@@H]2c2cccc(F)c2)c(C)c1[N+](=O)[O-] by removing a benzene_ring.,Cc1nn(CC(=O)N[C@H]2C[C@@H]2c2cccc(F)c2)c(C)c1[N+](=O)[O-],benzene_ring
+99992,Modify the molecule Cc1ccc(SCC(=O)c2cc(C)n([C@@H]3CCS(=O)(=O)C3)c2C)c(C)c1 by removing a benzene_ring.,Cc1ccc(SCC(=O)c2cc(C)n([C@@H]3CCS(=O)(=O)C3)c2C)c(C)c1,benzene_ring
+14083,Modify the molecule OCCCC[C@@H]1Nc2ccc(F)cc2[C@H]2OCCC[C@@H]12 by removing a hydroxyl.,OCCCC[C@@H]1Nc2ccc(F)cc2[C@H]2OCCC[C@@H]12,hydroxyl
+105294,Remove a benzene_ring from the molecule CC[C@@](C)([C@H](O)c1ccccc1)[NH+](C)C.,CC[C@@](C)([C@H](O)c1ccccc1)[NH+](C)C,benzene_ring
+73528,Please remove a amide from the molecule N#CCCCn1ccc(NC(=O)Cc2cccs2)n1.,N#CCCCn1ccc(NC(=O)Cc2cccs2)n1,amide
+140964,Remove a amide from the molecule C=CCN(C(=O)[C@@H](C[NH3+])CC(C)C)C(C)C.,C=CCN(C(=O)[C@@H](C[NH3+])CC(C)C)C(C)C,amide
+184741,Remove a amide from the molecule O=C(N/N=C/c1ccco1)c1ccc2[nH]cnc2c1.,O=C(N/N=C/c1ccco1)c1ccc2[nH]cnc2c1,amide
+165063,Remove a benzene_ring from the molecule O=S(=O)(c1cn[nH]c1)N1CCC[C@H](c2cccc(-c3cccc(F)c3)n2)C1.,O=S(=O)(c1cn[nH]c1)N1CCC[C@H](c2cccc(-c3cccc(F)c3)n2)C1,benzene_ring
+32242,Modify the molecule CCN1CCN(c2nc(NC[C@@H]3CCCO3)c3ccccc3[nH+]2)CC1 by removing a amine.,CCN1CCN(c2nc(NC[C@@H]3CCCO3)c3ccccc3[nH+]2)CC1,amine
+60509,Modify the molecule C[C@@H](NC(=O)N(C1CC1)[C@H](C)C1CC1)c1ccc(-c2ccncc2)cc1 by removing a benzene_ring.,C[C@@H](NC(=O)N(C1CC1)[C@H](C)C1CC1)c1ccc(-c2ccncc2)cc1,benzene_ring
+64813,Please remove a amide from the molecule CCC[C@@H](C)NC(=O)[C@H](C)C[NH2+]C.,CCC[C@@H](C)NC(=O)[C@H](C)C[NH2+]C,amide
+39954,Please remove a amide from the molecule COc1cc(C(=O)OCC(=O)Nc2cccc(C(C)=O)c2)ccc1C.,COc1cc(C(=O)OCC(=O)Nc2cccc(C(C)=O)c2)ccc1C,amide
+97204,Please remove a amine from the molecule CCC[C@@]1(C)C[NH+]=C(N)N1c1ccccc1.,CCC[C@@]1(C)C[NH+]=C(N)N1c1ccccc1,amine
+58745,Remove a halo from the molecule COC(=O)C[C@@H](C)N1CCN(S(=O)(=O)c2ccc(Cl)cc2)CC1.,COC(=O)C[C@@H](C)N1CCN(S(=O)(=O)c2ccc(Cl)cc2)CC1,halo
+246768,Please remove a amide from the molecule CC(C)[C@H]1C[NH+](Cc2ccco2)CCN1C(=O)c1ccc(Cn2cccn2)o1.,CC(C)[C@H]1C[NH+](Cc2ccco2)CCN1C(=O)c1ccc(Cn2cccn2)o1,amide
+95523,Remove a halo from the molecule CN(C)c1c(Cl)cccc1NC(=O)CCCCO.,CN(C)c1c(Cl)cccc1NC(=O)CCCCO,halo
+203730,Remove a amide from the molecule O=C(COC(=O)Cn1nc([O-])c2ccccc2c1=O)Nc1c(Cl)cccc1C(F)(F)F.,O=C(COC(=O)Cn1nc([O-])c2ccccc2c1=O)Nc1c(Cl)cccc1C(F)(F)F,amide
+179551,Modify the molecule O=C(NCc1cccc(C(=O)NC[C@H]2CCCO2)c1)Nc1ccc(F)c(F)c1 by removing a halo.,O=C(NCc1cccc(C(=O)NC[C@H]2CCCO2)c1)Nc1ccc(F)c(F)c1,halo
+178734,Please remove a amide from the molecule COc1ccc(C(=O)N2CCC(c3cc(=O)cc(C)[nH]3)CC2)cn1.,COc1ccc(C(=O)N2CCC(c3cc(=O)cc(C)[nH]3)CC2)cn1,amide
+94345,Remove a amide from the molecule Cc1ccccc1[C@H](C#N)NC(=O)[C@H]1CC(=O)N(C(C)C)C1.,Cc1ccccc1[C@H](C#N)NC(=O)[C@H]1CC(=O)N(C(C)C)C1,amide
+105741,Please remove a amide from the molecule Cn1c(SCC(=O)N2CCCCCC2)nnc1-c1cccnc1.,Cn1c(SCC(=O)N2CCCCCC2)nnc1-c1cccnc1,amide
+24590,Remove a amide from the molecule COC(=O)[C@H]1C[C@H]2CCCC[C@H]2N1C(=O)c1ccc(-c2nc(C)no2)cc1.,COC(=O)[C@H]1C[C@H]2CCCC[C@H]2N1C(=O)c1ccc(-c2nc(C)no2)cc1,amide
+1400,Modify the molecule C=CCSc1nc(N)c(C#N)cc1C#N by removing a amine.,C=CCSc1nc(N)c(C#N)cc1C#N,amine
+114282,Remove a halo from the molecule O=C1N[C@H](c2ccc(F)cc2)C(C(=O)c2cccs2)=C1O.,O=C1N[C@H](c2ccc(F)cc2)C(C(=O)c2cccs2)=C1O,halo
+180107,Please remove a halo from the molecule COC[C@@H](C)n1c(CCCl)nc2cc(C)cnc21.,COC[C@@H](C)n1c(CCCl)nc2cc(C)cnc21,halo
+2634,Remove a amide from the molecule CC(=O)NCCn1c(SCC(=O)[O-])nc2cccnc21.,CC(=O)NCCn1c(SCC(=O)[O-])nc2cccnc21,amide
+56894,Remove a nitro from the molecule CCNc1nnc(Sc2ccc(C(=O)NC3CC3)cc2[N+](=O)[O-])s1.,CCNc1nnc(Sc2ccc(C(=O)NC3CC3)cc2[N+](=O)[O-])s1,nitro
+206477,Please remove a halo from the molecule Cc1c([C@@H](C)NC(=O)CCc2nc3ccccc3s2)cnn1-c1ccc(F)cc1.,Cc1c([C@@H](C)NC(=O)CCc2nc3ccccc3s2)cnn1-c1ccc(F)cc1,halo
+8807,Please remove a benzene_ring from the molecule CCO[C@@H](C)c1nc(CNc2cccc(-n3nnnc3C)c2)cs1.,CCO[C@@H](C)c1nc(CNc2cccc(-n3nnnc3C)c2)cs1,benzene_ring
+162253,Modify the molecule CC(=O)C[C@H]1CCCCCN1C(=O)[C@@H]1CCS(=O)(=O)C1 by removing a amide.,CC(=O)C[C@H]1CCCCCN1C(=O)[C@@H]1CCS(=O)(=O)C1,amide
+194066,Modify the molecule CCc1nnc2ccc(S(=O)(=O)N(CC)c3ccccc3)cn12 by removing a benzene_ring.,CCc1nnc2ccc(S(=O)(=O)N(CC)c3ccccc3)cn12,benzene_ring
+229620,Please remove a amide from the molecule COc1ccc(N2C(=O)C(c3c(C(C)C)nn(-c4ccccc4)c3O)=C([n+]3ccccc3)C2=O)cc1.,COc1ccc(N2C(=O)C(c3c(C(C)C)nn(-c4ccccc4)c3O)=C([n+]3ccccc3)C2=O)cc1,amide
+43403,Modify the molecule Cc1ccc(C)c(C(=O)NC[C@H](O)Cc2ccccc2)c1 by removing a benzene_ring.,Cc1ccc(C)c(C(=O)NC[C@H](O)Cc2ccccc2)c1,benzene_ring
+98493,Modify the molecule CCc1ccc(CC)c(NC(=O)CC2CN(C(=O)OC(C)(C)C)C2)c1 by removing a amide.,CCc1ccc(CC)c(NC(=O)CC2CN(C(=O)OC(C)(C)C)C2)c1,amide
+171576,Modify the molecule CC(=O)NCC(=O)NCC(=O)N1C[C@H](c2ccc(F)cc2)C[C@@H]1C by removing a halo.,CC(=O)NCC(=O)NCC(=O)N1C[C@H](c2ccc(F)cc2)C[C@@H]1C,halo
+205052,Remove a nitrile from the molecule CCCn1cc(CC)cc1C#N.,CCCn1cc(CC)cc1C#N,nitrile
+7361,Please remove a benzene_ring from the molecule Cc1ccccc1N1CCN(Cc2cn3ccccc3[nH+]2)CC1.,Cc1ccccc1N1CCN(Cc2cn3ccccc3[nH+]2)CC1,benzene_ring
+13373,Modify the molecule O=c1[nH]c(CSc2nncs2)nc2ccc(Cl)cc12 by removing a halo.,O=c1[nH]c(CSc2nncs2)nc2ccc(Cl)cc12,halo
+59309,Remove a benzene_ring from the molecule CC[C@@](C)([NH3+])C(=O)Nc1cc(C(=O)[O-])cc(C(F)(F)F)c1.,CC[C@@](C)([NH3+])C(=O)Nc1cc(C(=O)[O-])cc(C(F)(F)F)c1,benzene_ring
+197568,Please remove a amine from the molecule COCC(=O)N1CC[C@@H](c2nc(C)cc(Nc3nc(C)cc(C)n3)n2)C1.,COCC(=O)N1CC[C@@H](c2nc(C)cc(Nc3nc(C)cc(C)n3)n2)C1,amine
+41302,Modify the molecule Cn1cc(NC(=O)c2cccc(CN3CCN(c4cnccn4)CC3)c2)cn1 by removing a benzene_ring.,Cn1cc(NC(=O)c2cccc(CN3CCN(c4cnccn4)CC3)c2)cn1,benzene_ring
+100042,Remove a halo from the molecule C[C@H]1C[C@@H](N2CCC[C@H](C(=O)Nc3ccc(Cl)cn3)C2)C(=O)O1.,C[C@H]1C[C@@H](N2CCC[C@H](C(=O)Nc3ccc(Cl)cn3)C2)C(=O)O1,halo
+111923,Please remove a benzene_ring from the molecule CCN(CC(C)(C)CS)c1ccccc1.,CCN(CC(C)(C)CS)c1ccccc1,benzene_ring
+147868,Remove a nitrile from the molecule N#C[C@H](c1ccccc1)N1CCN(Cc2csc(-c3ccoc3)n2)CC1.,N#C[C@H](c1ccccc1)N1CCN(Cc2csc(-c3ccoc3)n2)CC1,nitrile
+15238,Remove a amine from the molecule Cc1ccccc1C[NH+]1CCC(CN(C[C@H]2CCCO2)C(=O)[C@H]2C=c3ccccc3=[NH+]2)CC1.,Cc1ccccc1C[NH+]1CCC(CN(C[C@H]2CCCO2)C(=O)[C@H]2C=c3ccccc3=[NH+]2)CC1,amine
+104879,Modify the molecule CCCN[C@@]1(C#N)CC[C@H](SC2CCCCC2)C1 by removing a amine.,CCCN[C@@]1(C#N)CC[C@H](SC2CCCCC2)C1,amine
+146645,Remove a amide from the molecule O=C(CN1CCCOC1=O)NCc1nccc2ccccc12.,O=C(CN1CCCOC1=O)NCc1nccc2ccccc12,amide
+121200,Modify the molecule Cc1ccc(S(=O)(=O)N2CCOCC2)cc1C(=O)N1C[C@@H](C)C[C@@H](C)C1 by removing a benzene_ring.,Cc1ccc(S(=O)(=O)N2CCOCC2)cc1C(=O)N1C[C@@H](C)C[C@@H](C)C1,benzene_ring
+192909,Remove a amide from the molecule CN1CCN(C(=O)[C@H]2C[C@H]3CC[C@@H]2[NH2+]3)C(C)(C)C1=O.,CN1CCN(C(=O)[C@H]2C[C@H]3CC[C@@H]2[NH2+]3)C(C)(C)C1=O,amide
+137835,Modify the molecule Cc1ccc2[nH]c(=S)n([C@H]3CCC(=O)NC3)c2c1 by removing a amide.,Cc1ccc2[nH]c(=S)n([C@H]3CCC(=O)NC3)c2c1,amide
+191292,Please remove a benzene_ring from the molecule c1ncn(-c2ccc(N[C@@H]3CC[NH2+]C3)cc2)n1.,c1ncn(-c2ccc(N[C@@H]3CC[NH2+]C3)cc2)n1,benzene_ring
+93581,Please remove a nitro from the molecule CC[C@H]1CN(C(=O)Cn2cc([N+](=O)[O-])ccc2=O)CC[C@@H]1c1ccccc1.,CC[C@H]1CN(C(=O)Cn2cc([N+](=O)[O-])ccc2=O)CC[C@@H]1c1ccccc1,nitro
+112857,Please remove a amide from the molecule CNC(=O)[C@@H]1C[C@H]([NH3+])CN1C(=O)c1ccc(C(F)(F)F)nc1[O-].,CNC(=O)[C@@H]1C[C@H]([NH3+])CN1C(=O)c1ccc(C(F)(F)F)nc1[O-],amide
+166977,Remove a amine from the molecule FC(F)Oc1ccc(Br)cc1CNC[C@@H]1COc2ccccc2O1.,FC(F)Oc1ccc(Br)cc1CNC[C@@H]1COc2ccccc2O1,amine
+54472,Modify the molecule C[C@H]([NH2+]Cc1cnc(N2CCOCC2)nc1)c1ccc(F)c(F)c1 by removing a benzene_ring.,C[C@H]([NH2+]Cc1cnc(N2CCOCC2)nc1)c1ccc(F)c(F)c1,benzene_ring
+36896,Remove a benzene_ring from the molecule C[C@@H]1C[C@@H](NC(=O)Nc2ccccn2)CC[NH+]1Cc1ccccc1.,C[C@@H]1C[C@@H](NC(=O)Nc2ccccn2)CC[NH+]1Cc1ccccc1,benzene_ring
+136721,Modify the molecule CCOc1cc(C(=O)[O-])c(NC(=O)c2ccccc2OC)cc1OC by removing a benzene_ring.,CCOc1cc(C(=O)[O-])c(NC(=O)c2ccccc2OC)cc1OC,benzene_ring
+211588,Remove a benzene_ring from the molecule Cc1ccccc1N1C(=O)/C(=C/c2cc(Cl)cc(Cl)c2OS(C)(=O)=O)SC1=S.,Cc1ccccc1N1C(=O)/C(=C/c2cc(Cl)cc(Cl)c2OS(C)(=O)=O)SC1=S,benzene_ring
+110288,Please remove a benzene_ring from the molecule Cc1nc(N(C)CC[C@H](O)c2ccccc2)c2c(C)nn(C)c2n1.,Cc1nc(N(C)CC[C@H](O)c2ccccc2)c2c(C)nn(C)c2n1,benzene_ring
+108201,Please remove a amide from the molecule O=C(Cc1cccc([N+](=O)[O-])c1)N1CCC[C@H]1C[C@@H](O)c1ccco1.,O=C(Cc1cccc([N+](=O)[O-])c1)N1CCC[C@H]1C[C@@H](O)c1ccco1,amide
+221147,Modify the molecule Cc1cc(C)cc(NS(=O)(=O)c2ccc(N3CCOC3=O)cc2)c1 by removing a benzene_ring.,Cc1cc(C)cc(NS(=O)(=O)c2ccc(N3CCOC3=O)cc2)c1,benzene_ring
+86357,Modify the molecule C[C@H](CC(=O)N1CCC([C@@H]2Nc3ccccc3S(=O)(=O)N2)CC1)n1cncn1 by removing a amine.,C[C@H](CC(=O)N1CCC([C@@H]2Nc3ccccc3S(=O)(=O)N2)CC1)n1cncn1,amine
+137711,Modify the molecule COC(=O)[C@](C)(NCc1ccon1)C1CC1 by removing a amine.,COC(=O)[C@](C)(NCc1ccon1)C1CC1,amine
+7273,Please remove a halo from the molecule C[C@@H](C(=O)N1CC[C@@H](Oc2ccc(C(F)(F)F)cn2)C1)n1cncn1.,C[C@@H](C(=O)N1CC[C@@H](Oc2ccc(C(F)(F)F)cn2)C1)n1cncn1,halo
+188618,Please remove a benzene_ring from the molecule O=C([O-])c1ccc(S(=O)(=O)[O-])cc1N1C(=O)/C(=C\C=C\c2ccccc2)N=C1c1ccccc1.,O=C([O-])c1ccc(S(=O)(=O)[O-])cc1N1C(=O)/C(=C\C=C\c2ccccc2)N=C1c1ccccc1,benzene_ring
+78501,Please remove a benzene_ring from the molecule CCOc1ccccc1NC(=O)c1cc2sccc2n1CC.,CCOc1ccccc1NC(=O)c1cc2sccc2n1CC,benzene_ring
+177711,Remove a benzene_ring from the molecule C[C@H](NCc1ccnc(O[C@H]2CCOC2)c1)c1ccc(C(F)(F)F)cc1.,C[C@H](NCc1ccnc(O[C@H]2CCOC2)c1)c1ccc(C(F)(F)F)cc1,benzene_ring
+89063,Remove a halo from the molecule CC(C)n1cnn(C[NH+](CCC(F)(F)F)C2CCCC2)c1=S.,CC(C)n1cnn(C[NH+](CCC(F)(F)F)C2CCCC2)c1=S,halo
+159830,Remove a amine from the molecule O=[N+]([O-])c1ccc(Nc2cnn(-c3ncccn3)c2)c(Cl)c1.,O=[N+]([O-])c1ccc(Nc2cnn(-c3ncccn3)c2)c(Cl)c1,amine
+193521,Please remove a benzene_ring from the molecule NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H]1C[C@@H]1c1ccc(Cl)c(Cl)c1.,NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H]1C[C@@H]1c1ccc(Cl)c(Cl)c1,benzene_ring
+189081,Modify the molecule Cc1ccc(C(C)C)c(OCC(=O)Nn2c(=O)[nH]c3ccccc3c2=O)c1 by removing a benzene_ring.,Cc1ccc(C(C)C)c(OCC(=O)Nn2c(=O)[nH]c3ccccc3c2=O)c1,benzene_ring
+84783,Remove a benzene_ring from the molecule O=[N+]([O-])c1ccc(OC/C=C2\Oc3c(cccc3[N+](=O)[O-])[C@H]2N2CCOCC2)cc1.,O=[N+]([O-])c1ccc(OC/C=C2\Oc3c(cccc3[N+](=O)[O-])[C@H]2N2CCOCC2)cc1,benzene_ring
+196938,Please remove a amide from the molecule COc1ccc2c(c1)O[C@@]1(CCC(=O)N([C@@H](C)C(=O)[O-])CC1)CC2=O.,COc1ccc2c(c1)O[C@@]1(CCC(=O)N([C@@H](C)C(=O)[O-])CC1)CC2=O,amide
+38079,Remove a nitro from the molecule COc1ccc(CNC(=O)C(=O)N/N=C/c2ccccc2[N+](=O)[O-])cc1.,COc1ccc(CNC(=O)C(=O)N/N=C/c2ccccc2[N+](=O)[O-])cc1,nitro
+25775,Remove a amide from the molecule CCNC(=O)c1ccccc1NC(=O)c1ccnc(OC(C)(C)C)c1.,CCNC(=O)c1ccccc1NC(=O)c1ccnc(OC(C)(C)C)c1,amide
+140454,Please remove a amide from the molecule O=C(c1cn(C(c2ccccc2)c2ccccc2)nn1)N1CC[NH+](Cc2cccnc2)CC1.,O=C(c1cn(C(c2ccccc2)c2ccccc2)nn1)N1CC[NH+](Cc2cccnc2)CC1,amide
+171964,Modify the molecule CCNC(=O)Nc1cccc(NC(=O)C(=O)NC2CCCCCC2)c1 by removing a amide.,CCNC(=O)Nc1cccc(NC(=O)C(=O)NC2CCCCCC2)c1,amide
+239514,Please remove a amide from the molecule CCCNC(=O)C[NH2+][C@H]1C[C@@H](C)[NH+](C)C[C@@H]1C.,CCCNC(=O)C[NH2+][C@H]1C[C@@H](C)[NH+](C)C[C@@H]1C,amide
+25392,Please remove a benzene_ring from the molecule O=C(CSc1nnc(-c2ccccc2Br)n1Cc1ccccc1)C1=NC=CC1.,O=C(CSc1nnc(-c2ccccc2Br)n1Cc1ccccc1)C1=NC=CC1,benzene_ring
+178745,Please remove a benzene_ring from the molecule COc1ccc(S(=O)(=O)N2CCC[C@@H]2C(=O)Nc2ccc(C)cc2)cc1.,COc1ccc(S(=O)(=O)N2CCC[C@@H]2C(=O)Nc2ccc(C)cc2)cc1,benzene_ring
+106871,Please remove a halo from the molecule O=C(CCc1ccc(O)cc1)N/N=C/c1cc(Cl)cc(Cl)c1O.,O=C(CCc1ccc(O)cc1)N/N=C/c1cc(Cl)cc(Cl)c1O,halo
+139970,Modify the molecule CC[NH+](C)C[C@@H]1CCN(C(=O)c2ccc(C[C@@H]3CC(=O)NC3=O)cc2)C1 by removing a amide.,CC[NH+](C)C[C@@H]1CCN(C(=O)c2ccc(C[C@@H]3CC(=O)NC3=O)cc2)C1,amide
+7573,Remove a benzene_ring from the molecule C=CCN(Cc1nc(-c2ccccc2)no1)S(=O)(=O)c1ccc(Br)cc1.,C=CCN(Cc1nc(-c2ccccc2)no1)S(=O)(=O)c1ccc(Br)cc1,benzene_ring
+151759,Please remove a halo from the molecule Clc1ccc(OCC2=NN3C(=NN[C@@H]3[C@@H]3C=C(c4ccccc4)N=N3)S2)cc1.,Clc1ccc(OCC2=NN3C(=NN[C@@H]3[C@@H]3C=C(c4ccccc4)N=N3)S2)cc1,halo
+175994,Please remove a hydroxyl from the molecule CC/C(=N/NC(=O)c1ccc(F)cc1)c1cc(Cl)cc(Cl)c1O.,CC/C(=N/NC(=O)c1ccc(F)cc1)c1cc(Cl)cc(Cl)c1O,hydroxyl
+108331,Modify the molecule Cc1nc2ccccn2c1C(=O)Nc1ccc2c(c1)N(C(=O)C(C)C)CCC2 by removing a amide.,Cc1nc2ccccn2c1C(=O)Nc1ccc2c(c1)N(C(=O)C(C)C)CCC2,amide
+178729,Remove a benzene_ring from the molecule Cc1cc(C)c(C(=O)CSc2nnc(C3CC3)n2-c2ccccc2)cc1C.,Cc1cc(C)c(C(=O)CSc2nnc(C3CC3)n2-c2ccccc2)cc1C,benzene_ring
+147135,Modify the molecule Cc1nnc2ccc(N3CCN(Cc4ccccc4N4CCOCC4)CC3)nn12 by removing a benzene_ring.,Cc1nnc2ccc(N3CCN(Cc4ccccc4N4CCOCC4)CC3)nn12,benzene_ring
+106625,Modify the molecule C/C=C/C=C/C(=O)NCc1ccc(S(=O)(=O)NC)s1 by removing a amide.,C/C=C/C=C/C(=O)NCc1ccc(S(=O)(=O)NC)s1,amide
+152669,Please remove a amide from the molecule Cc1cccc(C)c1OCC(=O)NC[C@H](C)c1ccsc1.,Cc1cccc(C)c1OCC(=O)NC[C@H](C)c1ccsc1,amide
+148301,Remove a nitrile from the molecule C[C@@](CO)(NC(=O)Nc1ccc(OCc2cccc(C#N)c2)cc1)C1CC1.,C[C@@](CO)(NC(=O)Nc1ccc(OCc2cccc(C#N)c2)cc1)C1CC1,nitrile
+227042,Remove a nitro from the molecule CC(C)(C)OC(=O)N[C@H]1CCCN(c2nc3cc([N+](=O)[O-])ccc3o2)C1.,CC(C)(C)OC(=O)N[C@H]1CCCN(c2nc3cc([N+](=O)[O-])ccc3o2)C1,nitro
+146784,Modify the molecule CC(=O)Nc1cccc(NC(=O)CSc2nc3cc(Cl)ccc3n2Cc2ccccc2)c1 by removing a amide.,CC(=O)Nc1cccc(NC(=O)CSc2nc3cc(Cl)ccc3n2Cc2ccccc2)c1,amide
+116523,Remove a halo from the molecule COc1cc2c(c(C[NH+]3CCC(c4nc(C(F)(F)F)c[nH]4)CC3)c1)O[C@H](C)C2.,COc1cc2c(c(C[NH+]3CCC(c4nc(C(F)(F)F)c[nH]4)CC3)c1)O[C@H](C)C2,halo
+20940,Modify the molecule CNS(=O)(=O)c1ccc(CNC(=O)N(C[C@@H]2C[C@@H]2C)C(C)C)s1 by removing a amine.,CNS(=O)(=O)c1ccc(CNC(=O)N(C[C@@H]2C[C@@H]2C)C(C)C)s1,amine
+117429,Please remove a benzene_ring from the molecule C[C@H](OC(=O)c1cccc(OC[C@@H]2CCCO2)c1)[C@H]1CCCO1.,C[C@H](OC(=O)c1cccc(OC[C@@H]2CCCO2)c1)[C@H]1CCCO1,benzene_ring
+238617,Remove a amide from the molecule CCc1[nH]c2ccc(C(=O)N[C@H]3CCCOC3)cc2c1C.,CCc1[nH]c2ccc(C(=O)N[C@H]3CCCOC3)cc2c1C,amide
+75061,Modify the molecule O=S(=O)(Nc1ccc2c(c1)OCO2)c1ccccc1Cl by removing a halo.,O=S(=O)(Nc1ccc2c(c1)OCO2)c1ccccc1Cl,halo
+27316,Remove a benzene_ring from the molecule COc1ccc(C[NH+]2CCC(Oc3cccc(C#N)c3)CC2)cc1OC.,COc1ccc(C[NH+]2CCC(Oc3cccc(C#N)c3)CC2)cc1OC,benzene_ring
+31110,Remove a amide from the molecule CCc1[nH]c([C@H]2C[NH+](C)C[C@@H]2C(=O)N2CCCC2)c(C)[nH+]1.,CCc1[nH]c([C@H]2C[NH+](C)C[C@@H]2C(=O)N2CCCC2)c(C)[nH+]1,amide
+156620,Please remove a benzene_ring from the molecule CC/[NH+]=C(/N[C@H]1C[C@@H]1c1cccc(Cl)c1)N[C@@H]1CCC(=O)NC1.,CC/[NH+]=C(/N[C@H]1C[C@@H]1c1cccc(Cl)c1)N[C@@H]1CCC(=O)NC1,benzene_ring
+84283,Modify the molecule Cn1c([C@H]2CCCN(C(=O)CCc3cccnc3)C2)n[nH]c1=S by removing a amide.,Cn1c([C@H]2CCCN(C(=O)CCc3cccnc3)C2)n[nH]c1=S,amide
+213636,Modify the molecule CCOC(=O)N1CCN(C(=O)c2cccc(OCc3nnnn3C(C)C)c2)CC1 by removing a amide.,CCOC(=O)N1CCN(C(=O)c2cccc(OCc3nnnn3C(C)C)c2)CC1,amide
+139904,Modify the molecule O=C(Nc1cnn(-c2ncccn2)c1)Nc1ccc(Cl)cc1Cl by removing a halo.,O=C(Nc1cnn(-c2ncccn2)c1)Nc1ccc(Cl)cc1Cl,halo
+149169,Modify the molecule Cc1ccc(NC(=O)C[NH2+]CCc2ccccc2)cc1C by removing a benzene_ring.,Cc1ccc(NC(=O)C[NH2+]CCc2ccccc2)cc1C,benzene_ring
+140490,Remove a nitro from the molecule CC(C)=C/C([O-])=N/S(=O)(=O)c1cccc([N+](=O)[O-])c1.,CC(C)=C/C([O-])=N/S(=O)(=O)c1cccc([N+](=O)[O-])c1,nitro
+177693,Remove a benzene_ring from the molecule CS(=O)(=O)CCCNC(=O)NCCc1cc(F)ccc1F.,CS(=O)(=O)CCCNC(=O)NCCc1cc(F)ccc1F,benzene_ring
+45876,Modify the molecule Cn1c(=O)c2cc(C(=O)N[C@H]3CCOc4ccccc43)cnc2n(C)c1=O by removing a amide.,Cn1c(=O)c2cc(C(=O)N[C@H]3CCOc4ccccc43)cnc2n(C)c1=O,amide
+103357,Please remove a amide from the molecule COCCSc1ccccc1C(=O)N1C[C@H](C)O[C@@H](C)C1.,COCCSc1ccccc1C(=O)N1C[C@H](C)O[C@@H](C)C1,amide
+229004,Please remove a benzene_ring from the molecule Cc1csc(-c2cccc(C(=O)NC3CC3)c2)n1.,Cc1csc(-c2cccc(C(=O)NC3CC3)c2)n1,benzene_ring
+68051,Modify the molecule CCOc1ccc([C@H]2C3=C(CC(C)(C)CC3=O)Nc3nc(SCC)nn32)cc1 by removing a benzene_ring.,CCOc1ccc([C@H]2C3=C(CC(C)(C)CC3=O)Nc3nc(SCC)nn32)cc1,benzene_ring
+199768,Modify the molecule CCc1ccc([C@H](CO)NC(=O)Cc2ccc(OC)cc2)cc1 by removing a hydroxyl.,CCc1ccc([C@H](CO)NC(=O)Cc2ccc(OC)cc2)cc1,hydroxyl
+219514,Please remove a amide from the molecule CCc1ccccc1NC(=S)N/N=C1\C(=O)N(C)c2ccc(S(=O)(=O)N3CCOCC3)cc21.,CCc1ccccc1NC(=S)N/N=C1\C(=O)N(C)c2ccc(S(=O)(=O)N3CCOCC3)cc21,amide
+143948,Modify the molecule CCCn1nnnc1NCc1c(Cl)cccc1Cl by removing a benzene_ring.,CCCn1nnnc1NCc1c(Cl)cccc1Cl,benzene_ring
+48464,Modify the molecule CC(C)(C)c1nn(C2CCCCC2)c(N)c1[N+](=O)[O-] by removing a amine.,CC(C)(C)c1nn(C2CCCCC2)c(N)c1[N+](=O)[O-],amine
+16210,Modify the molecule O=C(C1=NNc2ccc(Cl)cc2S1(=O)=O)N1CCOCC1 by removing a amide.,O=C(C1=NNc2ccc(Cl)cc2S1(=O)=O)N1CCOCC1,amide
+219599,Remove a amide from the molecule CO[C@@H]1CCCC[C@H]1[NH2+]CCC(=O)NC1CC1.,CO[C@@H]1CCCC[C@H]1[NH2+]CCC(=O)NC1CC1,amide
+249226,Remove a halo from the molecule Cc1ccc(C(=O)NC[C@@H](c2cccs2)S(=O)(=O)c2ccc(Cl)cc2)cc1.,Cc1ccc(C(=O)NC[C@@H](c2cccs2)S(=O)(=O)c2ccc(Cl)cc2)cc1,halo
+50173,Remove a benzene_ring from the molecule C[C@@H](Oc1ccc(Cl)cc1)C(=O)N1CCC(OCc2ccc(F)cc2)CC1.,C[C@@H](Oc1ccc(Cl)cc1)C(=O)N1CCC(OCc2ccc(F)cc2)CC1,benzene_ring
+243124,Please remove a benzene_ring from the molecule CN(c1ccccc1)S(=O)(=O)c1cccc(C(=O)OCc2cccc(C#N)c2)c1.,CN(c1ccccc1)S(=O)(=O)c1cccc(C(=O)OCc2cccc(C#N)c2)c1,benzene_ring
+23278,Remove a hydroxyl from the molecule Nc1ncnc2c1nc(SCc1ccc3nsnc3c1)n2C[C@H](O)CO.,Nc1ncnc2c1nc(SCc1ccc3nsnc3c1)n2C[C@H](O)CO,hydroxyl
+236950,Remove a halo from the molecule Cc1c(N[C@@H](C)C(=O)Nc2cc(Cl)ccc2Cl)c(=O)n(-c2ccccc2)n1C.,Cc1c(N[C@@H](C)C(=O)Nc2cc(Cl)ccc2Cl)c(=O)n(-c2ccccc2)n1C,halo
+86283,Please remove a amide from the molecule CN(C(=O)c1cccc2c1OCCO2)c1cccc2ncccc12.,CN(C(=O)c1cccc2c1OCCO2)c1cccc2ncccc12,amide
+176313,Remove a halo from the molecule Cc1cc(C)nc(N[C@@]2(C(F)(F)F)N=C(O)N(CCc3ccccc3)C2=O)n1.,Cc1cc(C)nc(N[C@@]2(C(F)(F)F)N=C(O)N(CCc3ccccc3)C2=O)n1,halo
+221327,Remove a benzene_ring from the molecule COC(=O)[C@H]1[C@H]2c3ccccc3O[C@]1(C)N=c1s/c(=C\c3ccccc3OC)c(=O)n12.,COC(=O)[C@H]1[C@H]2c3ccccc3O[C@]1(C)N=c1s/c(=C\c3ccccc3OC)c(=O)n12,benzene_ring
+26247,Modify the molecule CC(C)(C)c1ccc(NC(=O)c2cccc(CN3CCCC3=O)c2)cc1 by removing a benzene_ring.,CC(C)(C)c1ccc(NC(=O)c2cccc(CN3CCCC3=O)c2)cc1,benzene_ring
+41286,Please remove a benzene_ring from the molecule Cc1cccc(OC[C@@H](C)[NH2+][C@H](C)c2cccnc2)c1.,Cc1cccc(OC[C@@H](C)[NH2+][C@H](C)c2cccnc2)c1,benzene_ring
+219845,Modify the molecule OCC[NH+](C1CC[NH2+]CC1)C1CC1 by removing a hydroxyl.,OCC[NH+](C1CC[NH2+]CC1)C1CC1,hydroxyl
+222426,Please remove a amide from the molecule Cc1ncsc1C(=O)NNC(=O)NC[C@H]1CCC(C)(C)c2ccccc21.,Cc1ncsc1C(=O)NNC(=O)NC[C@H]1CCC(C)(C)c2ccccc21,amide
+9500,Please remove a benzene_ring from the molecule [NH3+][C@@H](Cc1ccc(F)c(Br)c1)c1ccc(Cl)cn1.,[NH3+][C@@H](Cc1ccc(F)c(Br)c1)c1ccc(Cl)cn1,benzene_ring
+67027,Modify the molecule CCCn1nc(C(=O)OCc2cccc(Cl)c2)c2ccccc2c1=O by removing a benzene_ring.,CCCn1nc(C(=O)OCc2cccc(Cl)c2)c2ccccc2c1=O,benzene_ring
+190276,Modify the molecule C[C@H](Oc1ccc(Br)cc1)C(=O)Nc1ccc2c(c1)COC2 by removing a amide.,C[C@H](Oc1ccc(Br)cc1)C(=O)Nc1ccc2c(c1)COC2,amide
+57111,Modify the molecule CC[C@@H]1CC(=O)N(Cc2ccc(OC)c(C#CCO)c2)C1 by removing a amide.,CC[C@@H]1CC(=O)N(Cc2ccc(OC)c(C#CCO)c2)C1,amide
+62476,Remove a benzene_ring from the molecule CSCC[C@@H](C)N(C)C(=O)N[C@H]1CCN(c2ccccc2)C1.,CSCC[C@@H](C)N(C)C(=O)N[C@H]1CCN(c2ccccc2)C1,benzene_ring
+82092,Please remove a benzene_ring from the molecule COc1ccccc1S(=O)(=O)N1CCO[C@H](c2ccc(F)c(Cl)c2)C1.,COc1ccccc1S(=O)(=O)N1CCO[C@H](c2ccc(F)c(Cl)c2)C1,benzene_ring
+239247,Please remove a benzene_ring from the molecule CC[C@H](Cc1ccc(C)cc1)NC(=O)c1ccc2c(c1)OCC(=O)N2.,CC[C@H](Cc1ccc(C)cc1)NC(=O)c1ccc2c(c1)OCC(=O)N2,benzene_ring
+196107,Remove a benzene_ring from the molecule COc1cccc(CNC(=O)[C@@H]2CCCN(c3ccc(-c4cccs4)nn3)C2)c1.,COc1cccc(CNC(=O)[C@@H]2CCCN(c3ccc(-c4cccs4)nn3)C2)c1,benzene_ring
+22946,Please remove a amide from the molecule C=CCOc1c(OC)cccc1[C@@H]1CC(=O)Nc2c(-c3ccccc3)csc21.,C=CCOc1c(OC)cccc1[C@@H]1CC(=O)Nc2c(-c3ccccc3)csc21,amide
+142883,Modify the molecule CCNC(=O)c1c(NC(=O)c2cc(-c3ccccc3O)[nH]n2)sc2c1CCCC2 by removing a hydroxyl.,CCNC(=O)c1c(NC(=O)c2cc(-c3ccccc3O)[nH]n2)sc2c1CCCC2,hydroxyl
+24064,Remove a amide from the molecule Cc1cc(N2CCN(C)C(=O)C2(C)C)c([C@@H](C)[NH3+])cc1F.,Cc1cc(N2CCN(C)C(=O)C2(C)C)c([C@@H](C)[NH3+])cc1F,amide
+48789,Remove a benzene_ring from the molecule CCOc1cc(Br)ccc1C(=O)NC1CCCCC1.,CCOc1cc(Br)ccc1C(=O)NC1CCCCC1,benzene_ring
+120203,Please remove a amide from the molecule CCN(CC)C(=O)c1ccc2c(c1)N(CC(=O)Nc1ccc(Cl)cc1)C(=O)CS2.,CCN(CC)C(=O)c1ccc2c(c1)N(CC(=O)Nc1ccc(Cl)cc1)C(=O)CS2,amide
+249104,Remove a benzene_ring from the molecule CCc1ccccc1N1C[C@@H](C(=O)Nc2ccc([N+](=O)[O-])cc2OC)CC1=O.,CCc1ccccc1N1C[C@@H](C(=O)Nc2ccc([N+](=O)[O-])cc2OC)CC1=O,benzene_ring
+230624,Modify the molecule O=C(COc1ccc2oc3ccccc3c2c1)Nc1ccc2c(c1)OCCO2 by removing a amide.,O=C(COc1ccc2oc3ccccc3c2c1)Nc1ccc2c(c1)OCCO2,amide
+47215,Modify the molecule CCn1c(=O)oc2cc(NC(=O)c3cc(OC)c(OC)c(OC)c3)ccc21 by removing a amide.,CCn1c(=O)oc2cc(NC(=O)c3cc(OC)c(OC)c(OC)c3)ccc21,amide
+8134,Remove a benzene_ring from the molecule C[C@H]1CC(C(=O)N2CCCC[C@@H]2c2ncc(-c3cccc(F)c3)[nH]2)C[C@H](C)O1.,C[C@H]1CC(C(=O)N2CCCC[C@@H]2c2ncc(-c3cccc(F)c3)[nH]2)C[C@H](C)O1,benzene_ring
+187323,Please remove a amide from the molecule CN1C(=O)COc2ccc(NC(=O)C(=O)NCCc3c[nH]c4ccccc34)cc21.,CN1C(=O)COc2ccc(NC(=O)C(=O)NCCc3c[nH]c4ccccc34)cc21,amide
+116969,Remove a halo from the molecule CC(C)OC(=O)c1cc2c(ccn2-c2ccc(F)cc2)n1C(C)C.,CC(C)OC(=O)c1cc2c(ccn2-c2ccc(F)cc2)n1C(C)C,halo
+170996,Please remove a amide from the molecule C[C@H]1CCCCN1C(=O)C[NH+](CC(=O)N1CCCC[C@@H]1C)Cc1ccco1.,C[C@H]1CCCCN1C(=O)C[NH+](CC(=O)N1CCCC[C@@H]1C)Cc1ccco1,amide
+105663,Please remove a hydroxyl from the molecule C[C@H](O)[C@H](C)[NH2+]C(C)(C)CC(C)(C)C.,C[C@H](O)[C@H](C)[NH2+]C(C)(C)CC(C)(C)C,hydroxyl
+223392,Remove a benzene_ring from the molecule Cc1ccc(C)c(OCC(=O)N/N=C/c2ccc(O)c([N+](=O)[O-])c2)c1C.,Cc1ccc(C)c(OCC(=O)N/N=C/c2ccc(O)c([N+](=O)[O-])c2)c1C,benzene_ring
+34671,Please remove a halo from the molecule N#C[C@H](C(=O)[C@@H]1CCC(=O)N1C(=O)c1ccc(Cl)cc1)c1nc2cc(C(F)(F)F)ccc2s1.,N#C[C@H](C(=O)[C@@H]1CCC(=O)N1C(=O)c1ccc(Cl)cc1)c1nc2cc(C(F)(F)F)ccc2s1,halo
+197618,Please remove a benzene_ring from the molecule C=CCN(C(=O)Cc1ccc(C)cc1)c1ccccc1.,C=CCN(C(=O)Cc1ccc(C)cc1)c1ccccc1,benzene_ring
+191432,Remove a halo from the molecule C[C@@H](Oc1ccc(Cl)cc1Cl)C(=O)NNC(=O)Nc1ccc(Cl)cc1.,C[C@@H](Oc1ccc(Cl)cc1Cl)C(=O)NNC(=O)Nc1ccc(Cl)cc1,halo
+52098,Modify the molecule CCOc1ccc(NC(=O)[C@H](C)Sc2c([O-])on[n+]2-c2ccccc2)cc1 by removing a amide.,CCOc1ccc(NC(=O)[C@H](C)Sc2c([O-])on[n+]2-c2ccccc2)cc1,amide
+4602,Please remove a benzene_ring from the molecule C/C(=N/NC(=O)c1ccc(O)cc1)c1cccs1.,C/C(=N/NC(=O)c1ccc(O)cc1)c1cccs1,benzene_ring
+53083,Modify the molecule CN(C[C@H](O)c1ccc(F)c(F)c1)[C@@H](CCO)c1ccccc1 by removing a benzene_ring.,CN(C[C@H](O)c1ccc(F)c(F)c1)[C@@H](CCO)c1ccccc1,benzene_ring
+27869,Please remove a amide from the molecule CC(C)CCNC(=O)[C@@H](NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2c3ccccc3C(=O)N12)C(C)C.,CC(C)CCNC(=O)[C@@H](NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2c3ccccc3C(=O)N12)C(C)C,amide
+227027,Modify the molecule COC(=O)c1ccc(NC(=O)c2ncccc2C(F)(F)F)cc1Cl by removing a halo.,COC(=O)c1ccc(NC(=O)c2ncccc2C(F)(F)F)cc1Cl,halo
+3745,Remove a halo from the molecule O=C(Cc1cccc(F)c1)NCC(=O)N1CCCCC[C@@H]1c1ccncc1.,O=C(Cc1cccc(F)c1)NCC(=O)N1CCCCC[C@@H]1c1ccncc1,halo
+111840,Remove a halo from the molecule O=C(CNC(=O)C(c1ccccc1)c1ccccc1)N/N=C/c1ccccc1Cl.,O=C(CNC(=O)C(c1ccccc1)c1ccccc1)N/N=C/c1ccccc1Cl,halo
+77021,Modify the molecule Cn1c(C2CC2)nc2cc(NC(=O)C(=O)N[C@@H]3CCCC[C@H]3CO)ccc21 by removing a hydroxyl.,Cn1c(C2CC2)nc2cc(NC(=O)C(=O)N[C@@H]3CCCC[C@H]3CO)ccc21,hydroxyl
+203863,Please remove a hydroxyl from the molecule CCOC1CC[NH+](CC[C@H]2CCC[C@H]2O)CC1.,CCOC1CC[NH+](CC[C@H]2CCC[C@H]2O)CC1,hydroxyl
+113310,Modify the molecule O=C(CN1CCN(Cc2ccc(F)cc2Cl)C1=O)NCc1cccs1 by removing a benzene_ring.,O=C(CN1CCN(Cc2ccc(F)cc2Cl)C1=O)NCc1cccs1,benzene_ring
+188391,Modify the molecule Cc1nc(C)c(CNC(=O)N[C@@H](CO)c2ccc(Cl)cc2)s1 by removing a hydroxyl.,Cc1nc(C)c(CNC(=O)N[C@@H](CO)c2ccc(Cl)cc2)s1,hydroxyl
+133732,Please remove a amide from the molecule COc1cc2c(cc1OC)CN(C(=O)CSc1nnc([C@@H]3COc4ccccc4O3)n1C)CC2.,COc1cc2c(cc1OC)CN(C(=O)CSc1nnc([C@@H]3COc4ccccc4O3)n1C)CC2,amide
+225286,Remove a halo from the molecule Cc1cc(/C=C2/C(=N)N3C(c4ccccc4)=CSC3=NC2=O)c(C)n1-c1ccc(F)c(Cl)c1.,Cc1cc(/C=C2/C(=N)N3C(c4ccccc4)=CSC3=NC2=O)c(C)n1-c1ccc(F)c(Cl)c1,halo
+82720,Modify the molecule C[C@H](N[C@@H]1N=NC(=O)NC1=O)C(=O)N/N=C/c1ccc(Cl)cc1Cl by removing a benzene_ring.,C[C@H](N[C@@H]1N=NC(=O)NC1=O)C(=O)N/N=C/c1ccc(Cl)cc1Cl,benzene_ring
+212976,Please remove a amine from the molecule CCOc1ccc(N)cc1C[NH+](CC)Cc1ccccn1.,CCOc1ccc(N)cc1C[NH+](CC)Cc1ccccn1,amine
+196847,Remove a benzene_ring from the molecule CCOc1ccc([C@H](C)NC(=O)N2C[C@@H](C)O[C@H](c3ccccc3)C2)cc1OC.,CCOc1ccc([C@H](C)NC(=O)N2C[C@@H](C)O[C@H](c3ccccc3)C2)cc1OC,benzene_ring
+84438,Modify the molecule Cc1csc([C@H](NC(=O)c2cnn(C(C)C)c2C)C2CC2)n1 by removing a amide.,Cc1csc([C@H](NC(=O)c2cnn(C(C)C)c2C)C2CC2)n1,amide
+184099,Remove a amide from the molecule CC(C)[C@H](CO)[NH2+][C@@H](C)C(=O)N1CCCC1.,CC(C)[C@H](CO)[NH2+][C@@H](C)C(=O)N1CCCC1,amide
+43626,Remove a benzene_ring from the molecule Cc1ccc(OCC[C@@H]2CCC[C@@]2([NH3+])CO)cc1C.,Cc1ccc(OCC[C@@H]2CCC[C@@]2([NH3+])CO)cc1C,benzene_ring
+50725,Remove a benzene_ring from the molecule CC[C@H](CNC(=O)c1occc1Br)Oc1ccccc1F.,CC[C@H](CNC(=O)c1occc1Br)Oc1ccccc1F,benzene_ring
+197696,Please remove a benzene_ring from the molecule Cc1ccc(-n2ncc(NCCNC(=O)c3ccccc3Cl)c(Cl)c2=O)cc1Cl.,Cc1ccc(-n2ncc(NCCNC(=O)c3ccccc3Cl)c(Cl)c2=O)cc1Cl,benzene_ring
+82383,Modify the molecule CCSC[C@@H](C)N(C)C(=O)N[C@@H](C)c1nnnn1-c1ccccc1 by removing a benzene_ring.,CCSC[C@@H](C)N(C)C(=O)N[C@@H](C)c1nnnn1-c1ccccc1,benzene_ring
+88519,Modify the molecule COc1ccc(Cn2nnnc2[C@H](c2cc3ccc(C)cc3[nH]c2=O)N2CCc3ccccc32)cc1 by removing a benzene_ring.,COc1ccc(Cn2nnnc2[C@H](c2cc3ccc(C)cc3[nH]c2=O)N2CCc3ccccc32)cc1,benzene_ring
+96907,Modify the molecule CN(CC(=O)Nc1ccc(Cl)cc1)S(=O)(=O)c1ccc2c(c1)c(=O)n(C)c(=O)n2C by removing a halo.,CN(CC(=O)Nc1ccc(Cl)cc1)S(=O)(=O)c1ccc2c(c1)c(=O)n(C)c(=O)n2C,halo
+30780,Remove a halo from the molecule O[C@]12CCCC[C@@H]1C[NH+](Cc1ncccc1C(F)(F)F)CC2.,O[C@]12CCCC[C@@H]1C[NH+](Cc1ncccc1C(F)(F)F)CC2,halo
+133997,Please remove a benzene_ring from the molecule C[C@@H]1CCCC[C@H]1n1ccc2nc3ccn(CCc4ccccc4)c(=O)c3cc2c1=O.,C[C@@H]1CCCC[C@H]1n1ccc2nc3ccn(CCc4ccccc4)c(=O)c3cc2c1=O,benzene_ring
+113282,Remove a halo from the molecule CC[C@H]([NH2+][C@H](CO)c1ccc(Cl)cc1)c1ccc2c(c1)OCCO2.,CC[C@H]([NH2+][C@H](CO)c1ccc(Cl)cc1)c1ccc2c(c1)OCCO2,halo
+224140,Remove a amide from the molecule CC[C@]1(N(C)C)C(=O)N(c2ccccc2)C(=O)N1c1ccccc1.,CC[C@]1(N(C)C)C(=O)N(c2ccccc2)C(=O)N1c1ccccc1,amide
+207367,Modify the molecule CCn1c(C(=O)NC2CCCCCC2)cc2cc(S(=O)(=O)N(C)C)ccc21 by removing a amide.,CCn1c(C(=O)NC2CCCCCC2)cc2cc(S(=O)(=O)N(C)C)ccc21,amide
+10234,Remove a benzene_ring from the molecule CCCOc1ccc([C@H]([NH3+])CC(=O)[O-])cc1.,CCCOc1ccc([C@H]([NH3+])CC(=O)[O-])cc1,benzene_ring
+16395,Remove a amide from the molecule CN(Cc1nc2ccccc2c(=O)[nH]1)C(=O)c1csc(S(=O)(=O)N2CCc3ccccc3C2)c1.,CN(Cc1nc2ccccc2c(=O)[nH]1)C(=O)c1csc(S(=O)(=O)N2CCc3ccccc3C2)c1,amide
+189170,Please remove a amide from the molecule C/N=C1/S/C(=C\C(=O)Nc2ccc(Cl)cc2)C(=O)N1C.,C/N=C1/S/C(=C\C(=O)Nc2ccc(Cl)cc2)C(=O)N1C,amide
+70665,Please remove a hydroxyl from the molecule COC(=O)[C@H]1ON2CCCC[C@H]2[C@]1(O)C(F)(F)F.,COC(=O)[C@H]1ON2CCCC[C@H]2[C@]1(O)C(F)(F)F,hydroxyl
+88836,Modify the molecule O=C(COc1cccc(F)c1)N1CCC[C@@H](c2[nH]cc[nH+]2)C1 by removing a benzene_ring.,O=C(COc1cccc(F)c1)N1CCC[C@@H](c2[nH]cc[nH+]2)C1,benzene_ring
+179327,Please remove a halo from the molecule COC(=O)[C@@H]1C[C@H](O)CN1Cc1ccc(Br)c(C)c1.,COC(=O)[C@@H]1C[C@H](O)CN1Cc1ccc(Br)c(C)c1,halo
+90759,Please remove a halo from the molecule COc1cc(NC(=O)c2ccc(N(C)C)cc2)c(Cl)cc1NC(=O)c1ccccc1.,COc1cc(NC(=O)c2ccc(N(C)C)cc2)c(Cl)cc1NC(=O)c1ccccc1,halo
+46206,Modify the molecule C[C@H]1CCCC[C@@H]1[NH+]1CCC([NH2+]CCCNC(=O)c2ccc(F)cc2)CC1 by removing a halo.,C[C@H]1CCCC[C@@H]1[NH+]1CCC([NH2+]CCCNC(=O)c2ccc(F)cc2)CC1,halo
+125494,Please remove a nitro from the molecule O=[N+]([O-])c1cc(C(F)(F)F)cc(Cl)c1F.,O=[N+]([O-])c1cc(C(F)(F)F)cc(Cl)c1F,nitro
+29373,Modify the molecule Fc1ccc(NC(=S)N(Cc2cccc(F)c2)C[C@H]2CCCO2)cc1 by removing a amine.,Fc1ccc(NC(=S)N(Cc2cccc(F)c2)C[C@H]2CCCO2)cc1,amine
+112522,Please remove a benzene_ring from the molecule Fc1ccccc1C[NH2+]CCC[NH+]1CCOCC1.,Fc1ccccc1C[NH2+]CCC[NH+]1CCOCC1,benzene_ring
+245183,Please remove a amide from the molecule CCc1ccccc1-n1cc([O-])c(C(=O)N(C)CC(C)(C)O)n1.,CCc1ccccc1-n1cc([O-])c(C(=O)N(C)CC(C)(C)O)n1,amide
+105456,Modify the molecule CC(C)(C)OC(=O)NC[C@@H]1CCCCN1C(=O)c1ccc(C#N)cc1 by removing a nitrile.,CC(C)(C)OC(=O)NC[C@@H]1CCCCN1C(=O)c1ccc(C#N)cc1,nitrile
+147888,Please remove a halo from the molecule Cc1cc(Cl)ncc1NC(=O)N1CC[C@H](C)[C@H](O)C1.,Cc1cc(Cl)ncc1NC(=O)N1CC[C@H](C)[C@H](O)C1,halo
+128764,Modify the molecule Cc1ccc(Nc2c(C(=O)N3CCCC3)cnc3nc(C)ccc23)cc1 by removing a amide.,Cc1ccc(Nc2c(C(=O)N3CCCC3)cnc3nc(C)ccc23)cc1,amide
+236814,Remove a halo from the molecule COC(=O)C(C)(C)NC(=O)c1ccc(-c2cccc(Br)c2)nc1C.,COC(=O)C(C)(C)NC(=O)c1ccc(-c2cccc(Br)c2)nc1C,halo
+86602,Please remove a hydroxyl from the molecule Cc1ccc(CC(=O)N2C[C@@H]3CCCC[C@H]3C2)cc1O.,Cc1ccc(CC(=O)N2C[C@@H]3CCCC[C@H]3C2)cc1O,hydroxyl
+45618,Remove a amide from the molecule COc1nn(C)cc1C(=O)N1CCC[C@H](C(=O)N2CC[NH+](C3CCCCC3)CC2)C1.,COc1nn(C)cc1C(=O)N1CCC[C@H](C(=O)N2CC[NH+](C3CCCCC3)CC2)C1,amide
+32155,Modify the molecule C[C@H]1C[C@H]([NH2+]Cc2ccn(-c3ccccc3)n2)CN1c1ccccc1 by removing a benzene_ring.,C[C@H]1C[C@H]([NH2+]Cc2ccn(-c3ccccc3)n2)CN1c1ccccc1,benzene_ring
+19234,Remove a nitrile from the molecule C[C@@H](Nc1ncccc1C#N)c1ccc(Cl)cc1.,C[C@@H](Nc1ncccc1C#N)c1ccc(Cl)cc1,nitrile
+113150,Please remove a benzene_ring from the molecule COc1ccc2c(CSc3nnc(-c4ccc(OC(F)F)cc4)o3)cc(=O)oc2c1.,COc1ccc2c(CSc3nnc(-c4ccc(OC(F)F)cc4)o3)cc(=O)oc2c1,benzene_ring
+80554,Modify the molecule C/C=C/C=C/C(=O)NNC(=O)[C@@H](C)Oc1ccccc1F by removing a benzene_ring.,C/C=C/C=C/C(=O)NNC(=O)[C@@H](C)Oc1ccccc1F,benzene_ring
+5436,Remove a benzene_ring from the molecule Cc1ccc(-c2nnco2)cc1NC(=O)N1CC[C@@H]2CCCC[C@H]21.,Cc1ccc(-c2nnco2)cc1NC(=O)N1CC[C@@H]2CCCC[C@H]21,benzene_ring
+100253,Modify the molecule CC[C@H]1C(=O)N[C@](C)(CC)C(=O)N1CC(C)(C)S(C)(=O)=O by removing a amide.,CC[C@H]1C(=O)N[C@](C)(CC)C(=O)N1CC(C)(C)S(C)(=O)=O,amide
+130614,Remove a benzene_ring from the molecule CC(C)[C@@H](CO)NC(=O)Cc1c(F)cccc1F.,CC(C)[C@@H](CO)NC(=O)Cc1c(F)cccc1F,benzene_ring
+15435,Modify the molecule CCC[NH+]1CCc2c(sc(NC(=O)c3ccnn3C)c2C(=O)OC)C1 by removing a amide.,CCC[NH+]1CCc2c(sc(NC(=O)c3ccnn3C)c2C(=O)OC)C1,amide
+16581,Remove a amide from the molecule CNC(=O)C[C@H](C[NH3+])N(C)C(C)C.,CNC(=O)C[C@H](C[NH3+])N(C)C(C)C,amide
+150294,Remove a hydroxyl from the molecule COc1cccc(CN2CCN(c3ccnc(OC)c3C#N)C[C@@H]2CCO)c1.,COc1cccc(CN2CCN(c3ccnc(OC)c3C#N)C[C@@H]2CCO)c1,hydroxyl
+152290,Modify the molecule CC(=O)c1ccc(NC(=O)[C@H](C)n2nc(-c3ccco3)oc2=O)cc1 by removing a amide.,CC(=O)c1ccc(NC(=O)[C@H](C)n2nc(-c3ccco3)oc2=O)cc1,amide
+42803,Remove a hydroxyl from the molecule CC(C)Sc1nc2c(c(=O)[nH]c(=O)n2C)n1C[C@@H](O)COc1ccc(Cl)cc1.,CC(C)Sc1nc2c(c(=O)[nH]c(=O)n2C)n1C[C@@H](O)COc1ccc(Cl)cc1,hydroxyl
+84557,Remove a benzene_ring from the molecule CN1CCN(C(=O)CC[C@@H]2CCCN(C(=O)CCCc3ccccc3)C2)CC1.,CN1CCN(C(=O)CC[C@@H]2CCCN(C(=O)CCCc3ccccc3)C2)CC1,benzene_ring
+87231,Remove a nitro from the molecule O=C(c1ccccc1)[C@@H]([C@H](c1ccccc1)c1c[nH]c2ccccc12)[N+](=O)[O-].,O=C(c1ccccc1)[C@@H]([C@H](c1ccccc1)c1c[nH]c2ccccc12)[N+](=O)[O-],nitro
+57683,Remove a hydroxyl from the molecule CC[C@H](C)[C@@H](O)[C@]1(C[NH3+])CCc2ccccc2C1.,CC[C@H](C)[C@@H](O)[C@]1(C[NH3+])CCc2ccccc2C1,hydroxyl
+128233,Please remove a benzene_ring from the molecule Cc1n[nH]c2cc(NC(=O)[C@@H](c3ccccc3)N3CCCCC3=O)ccc12.,Cc1n[nH]c2cc(NC(=O)[C@@H](c3ccccc3)N3CCCCC3=O)ccc12,benzene_ring
+137709,Remove a nitro from the molecule COCC[NH2+]CC(=O)Nc1cccc([N+](=O)[O-])c1.,COCC[NH2+]CC(=O)Nc1cccc([N+](=O)[O-])c1,nitro
+94342,Modify the molecule CC1(C)[C@H](C(=O)[O-])[C@H]1C(=O)Nc1ccc(C(=O)Nc2cccnc2)c(Cl)c1 by removing a amide.,CC1(C)[C@H](C(=O)[O-])[C@H]1C(=O)Nc1ccc(C(=O)Nc2cccnc2)c(Cl)c1,amide
+213105,Please remove a benzene_ring from the molecule CC[C@H]1CCC[C@@H](NC(=O)C(=O)Nc2ccccc2OCC2CC2)C1.,CC[C@H]1CCC[C@@H](NC(=O)C(=O)Nc2ccccc2OCC2CC2)C1,benzene_ring
+181601,Please remove a benzene_ring from the molecule CC(C)CCOc1ccc(NC(=O)Nc2cccc(-c3nnco3)c2)cc1.,CC(C)CCOc1ccc(NC(=O)Nc2cccc(-c3nnco3)c2)cc1,benzene_ring
+131872,Modify the molecule C[C@H]1C[C@@H]([NH+](CC(=O)[O-])CC(F)(F)F)CC[C@H]1C by removing a halo.,C[C@H]1C[C@@H]([NH+](CC(=O)[O-])CC(F)(F)F)CC[C@H]1C,halo
+192165,Remove a amide from the molecule CCn1c(S[C@H](C)C(=O)N[C@@H]2CCCC[C@@H]2C)nc2sc(C)c(C)c2c1=O.,CCn1c(S[C@H](C)C(=O)N[C@@H]2CCCC[C@@H]2C)nc2sc(C)c(C)c2c1=O,amide
+184770,Modify the molecule COc1cc(/C=C2\S/C(=N/N=C/c3ccco3)NC2=O)ccc1O by removing a amide.,COc1cc(/C=C2\S/C(=N/N=C/c3ccco3)NC2=O)ccc1O,amide
+155820,Remove a benzene_ring from the molecule C[NH+]1CC[C@@H](NC(=O)[C@@H]2CCOc3ccccc32)[C@@H]1c1ccc(Cl)cc1.,C[NH+]1CC[C@@H](NC(=O)[C@@H]2CCOc3ccccc32)[C@@H]1c1ccc(Cl)cc1,benzene_ring
+5363,Modify the molecule CCC[C@H](NC(=O)c1cc(OC)ccc1Br)C(=O)OC by removing a benzene_ring.,CCC[C@H](NC(=O)c1cc(OC)ccc1Br)C(=O)OC,benzene_ring
+36935,Remove a amide from the molecule O=C1CN(C(=O)c2nn(Cc3ccccc3)c3c2CN(C(=O)[C@H]2CC24CCCCC4)CC3)CCN1.,O=C1CN(C(=O)c2nn(Cc3ccccc3)c3c2CN(C(=O)[C@H]2CC24CCCCC4)CC3)CCN1,amide
+234291,Modify the molecule CC(=O)Nc1cc(NC(=O)N(CCO)C2CC2)ccc1F by removing a benzene_ring.,CC(=O)Nc1cc(NC(=O)N(CCO)C2CC2)ccc1F,benzene_ring
+27491,Please remove a amide from the molecule C[NH+]1CCCCC[C@H]1C(=O)N1CCN(c2ccccc2C#N)CC1.,C[NH+]1CCCCC[C@H]1C(=O)N1CCN(c2ccccc2C#N)CC1,amide
+72883,Please remove a amine from the molecule Cc1n[nH]c(N/N=C\c2ccccc2)nc1=O.,Cc1n[nH]c(N/N=C\c2ccccc2)nc1=O,amine
+8730,Modify the molecule Cc1ccc(NC(=O)C[C@H](c2cccc(F)c2)n2cccc2)cc1F by removing a amide.,Cc1ccc(NC(=O)C[C@H](c2cccc(F)c2)n2cccc2)cc1F,amide
+241789,Please remove a benzene_ring from the molecule CCCCN(c1ccccc1)S(C)(=O)=O.,CCCCN(c1ccccc1)S(C)(=O)=O,benzene_ring
+22297,Please remove a amide from the molecule CCc1c(C(=O)N2CCC[C@@H](C(C)(C)C(=O)OC)C2)[nH]c(C)c1C(C)=O.,CCc1c(C(=O)N2CCC[C@@H](C(C)(C)C(=O)OC)C2)[nH]c(C)c1C(C)=O,amide
+161175,Modify the molecule Oc1ccc(CNc2cc(-c3ccc(F)cc3)nc3ccnn23)cc1 by removing a benzene_ring.,Oc1ccc(CNc2cc(-c3ccc(F)cc3)nc3ccnn23)cc1,benzene_ring
+226003,Please remove a benzene_ring from the molecule CC[NH+]1CCN(c2ccccc2C[NH+](C)[C@H]2CCCc3c2cnn3C)CC1.,CC[NH+]1CCN(c2ccccc2C[NH+](C)[C@H]2CCCc3c2cnn3C)CC1,benzene_ring
+177580,Modify the molecule O=C(C[C@@H]1CC(=O)Oc2ccccc21)Nc1ccc2[nH]ccc2c1 by removing a amide.,O=C(C[C@@H]1CC(=O)Oc2ccccc21)Nc1ccc2[nH]ccc2c1,amide
+40062,Modify the molecule Cc1ccc(O)c(-c2nc([C@H]3C[NH+]4CCN3CC4)no2)c1 by removing a benzene_ring.,Cc1ccc(O)c(-c2nc([C@H]3C[NH+]4CCN3CC4)no2)c1,benzene_ring
+8622,Please remove a benzene_ring from the molecule CC(=O)Nc1cccc(NC(=O)CSc2nnnn2-c2cc(C)ccc2C)c1.,CC(=O)Nc1cccc(NC(=O)CSc2nnnn2-c2cc(C)ccc2C)c1,benzene_ring
+107125,Modify the molecule COC(=O)c1cccc(/C=C/[NH+](C)C)c1[N+](=O)[O-] by removing a nitro.,COC(=O)c1cccc(/C=C/[NH+](C)C)c1[N+](=O)[O-],nitro
+169066,Modify the molecule C[C@@H](O)[C@H]1CCCC[NH+]1Cc1ccc(F)cc1C#N by removing a halo.,C[C@@H](O)[C@H]1CCCC[NH+]1Cc1ccc(F)cc1C#N,halo
+175843,Please remove a benzene_ring from the molecule CCc1ccccc1NC(=O)[C@H](C)[NH+]1CCCSCC1.,CCc1ccccc1NC(=O)[C@H](C)[NH+]1CCCSCC1,benzene_ring
+137040,Please remove a benzene_ring from the molecule Cc1cc2nc(S/C(=C\c3ccc(O)cc3)C(=O)[O-])[nH]c2cc1C.,Cc1cc2nc(S/C(=C\c3ccc(O)cc3)C(=O)[O-])[nH]c2cc1C,benzene_ring
+100256,Modify the molecule Cc1cccc([C@H](C)C(=O)N(C)CCC2CCN(c3cc[nH+]cc3)CC2)c1 by removing a benzene_ring.,Cc1cccc([C@H](C)C(=O)N(C)CCC2CCN(c3cc[nH+]cc3)CC2)c1,benzene_ring
+107523,Remove a amide from the molecule N#Cc1ccsc1NC(=O)CSc1nc2nn(-c3ccccc3)c(=O)c-2c2n1CCCCC2.,N#Cc1ccsc1NC(=O)CSc1nc2nn(-c3ccccc3)c(=O)c-2c2n1CCCCC2,amide
+242678,Please remove a amide from the molecule CC(=O)N1CCN(C(=O)C(=O)NCC2CCN(C(=O)c3ccccn3)CC2)CC1.,CC(=O)N1CCN(C(=O)C(=O)NCC2CCN(C(=O)c3ccccn3)CC2)CC1,amide
+95593,Please remove a amide from the molecule O=C1C[C@@H](NC(=O)N2CCC[C@@H]2C[NH+]2CCCCC2)CN1C1CC1.,O=C1C[C@@H](NC(=O)N2CCC[C@@H]2C[NH+]2CCCCC2)CN1C1CC1,amide
+22400,Remove a halo from the molecule CN1CCN(C(=O)c2cccn(Cc3ccc(C(F)(F)F)cc3)c2=O)CC1.,CN1CCN(C(=O)c2cccn(Cc3ccc(C(F)(F)F)cc3)c2=O)CC1,halo
+212434,Modify the molecule c1cnc(Oc2ccc(CN3CCCC[C@@H]3c3[nH]cc[nH+]3)cc2)cn1 by removing a benzene_ring.,c1cnc(Oc2ccc(CN3CCCC[C@@H]3c3[nH]cc[nH+]3)cc2)cn1,benzene_ring
+115914,Please remove a benzene_ring from the molecule COCCOc1cccc(NC(=O)N[C@@H](C)c2c(C)noc2C)c1.,COCCOc1cccc(NC(=O)N[C@@H](C)c2c(C)noc2C)c1,benzene_ring
+61049,Remove a benzene_ring from the molecule CCOc1ccc(NC(=O)[C@H]2Sc3nnc(CC)n3N[C@@H]2c2ccc(OC)c(Cl)c2)cc1.,CCOc1ccc(NC(=O)[C@H]2Sc3nnc(CC)n3N[C@@H]2c2ccc(OC)c(Cl)c2)cc1,benzene_ring
+238387,Please remove a amide from the molecule Cc1csc([C@@H](C)NC(=O)C[C@@H](NC(N)=O)c2cccs2)n1.,Cc1csc([C@@H](C)NC(=O)C[C@@H](NC(N)=O)c2cccs2)n1,amide
+179768,Modify the molecule CN(C)C(=O)c1cc(NC(=O)C(C)(C)F)ccc1Cl by removing a halo.,CN(C)C(=O)c1cc(NC(=O)C(C)(C)F)ccc1Cl,halo
+99537,Modify the molecule O=C(Nc1cnc2ccccc2n1)c1cc2c([nH]c1=O)CCCC2 by removing a amide.,O=C(Nc1cnc2ccccc2n1)c1cc2c([nH]c1=O)CCCC2,amide
+206149,Please remove a hydroxyl from the molecule N#CC1=C(N)Oc2cc(O)ccc2[C@@H]1c1ccncc1.,N#CC1=C(N)Oc2cc(O)ccc2[C@@H]1c1ccncc1,hydroxyl
+226632,Modify the molecule Cc1nnc(C[NH+]2CC[C@@H](COCc3ccccc3)C2)o1 by removing a benzene_ring.,Cc1nnc(C[NH+]2CC[C@@H](COCc3ccccc3)C2)o1,benzene_ring
+48965,Modify the molecule O=S(=O)(Oc1ccccc1C(F)(F)F)c1cc(F)ccc1Cl by removing a halo.,O=S(=O)(Oc1ccccc1C(F)(F)F)c1cc(F)ccc1Cl,halo
+215934,Modify the molecule [NH2+]=C([C@@H]1CSCCO1)N1CCCC1 by removing a amine.,[NH2+]=C([C@@H]1CSCCO1)N1CCCC1,amine
+212176,Please remove a hydroxyl from the molecule O=C(C[C@H]1CCCCO1)N1CCCc2cccc(O)c21.,O=C(C[C@H]1CCCCO1)N1CCCc2cccc(O)c21,hydroxyl
+133548,Please remove a amide from the molecule COc1ccc(C(=O)Nc2ccc3c(C(C)(C)C)cc(=O)[nH]c3c2)c(OC)c1.,COc1ccc(C(=O)Nc2ccc3c(C(C)(C)C)cc(=O)[nH]c3c2)c(OC)c1,amide
+206606,Remove a amide from the molecule O=C(C[NH+]1CCC[C@H](c2nc3ccccc3o2)C1)NC1CCCCC1.,O=C(C[NH+]1CCC[C@H](c2nc3ccccc3o2)C1)NC1CCCCC1,amide
+8874,Please remove a benzene_ring from the molecule COCc1ccccc1NC(=O)NC[C@@H](O)c1ccc2ccccc2c1.,COCc1ccccc1NC(=O)NC[C@@H](O)c1ccc2ccccc2c1,benzene_ring
+124547,Remove a hydroxyl from the molecule C[C@H](O)[C@@H]1CCC[NH+](CCc2ccc3c(c2)CCO3)C1.,C[C@H](O)[C@@H]1CCC[NH+](CCc2ccc3c(c2)CCO3)C1,hydroxyl
+42977,Modify the molecule CON(C)S(=O)(=O)c1cccc(C(=O)Nc2ccc(C)cc2F)c1 by removing a amide.,CON(C)S(=O)(=O)c1cccc(C(=O)Nc2ccc(C)cc2F)c1,amide
+68771,Remove a benzene_ring from the molecule COC[C@@H](NS(=O)(=O)c1cc(C)c(C)cc1[N+](=O)[O-])c1ccco1.,COC[C@@H](NS(=O)(=O)c1cc(C)c(C)cc1[N+](=O)[O-])c1ccco1,benzene_ring
+156977,Remove a amide from the molecule C[C@H](Oc1ccccc1)C(=O)NCc1ccc(C(=O)N2CC[NH+](C)CC2)cc1.,C[C@H](Oc1ccccc1)C(=O)NCc1ccc(C(=O)N2CC[NH+](C)CC2)cc1,amide
+73112,Please remove a amine from the molecule C[C@@H](C[C@@H]1CCC[NH2+]1)Nc1cnc2ccccc2c1.,C[C@@H](C[C@@H]1CCC[NH2+]1)Nc1cnc2ccccc2c1,amine
+6758,Modify the molecule c1cnc(CNC[C@@H]2CCC[NH2+]2)cn1 by removing a amine.,c1cnc(CNC[C@@H]2CCC[NH2+]2)cn1,amine
+62495,Remove a nitro from the molecule CCN(c1ncnc(NC[C@H]2CCCO2)c1[N+](=O)[O-])c1cccc2ccccc12.,CCN(c1ncnc(NC[C@H]2CCCO2)c1[N+](=O)[O-])c1cccc2ccccc12,nitro
+193258,Please remove a hydroxyl from the molecule Cc1ccc(C(=O)N2CCC3(CCC(=O)N(CC(=O)[O-])C3)CC2)cc1O.,Cc1ccc(C(=O)N2CCC3(CCC(=O)N(CC(=O)[O-])C3)CC2)cc1O,hydroxyl
+76375,Please remove a benzene_ring from the molecule CC(C)(C)C(=O)NCC(=O)OC(c1ccccc1)c1ccccc1.,CC(C)(C)C(=O)NCC(=O)OC(c1ccccc1)c1ccccc1,benzene_ring
+120590,Remove a amine from the molecule Cc1c(C(=O)N2CCCCC2)c(S(=O)(=O)NCc2ccc3c(c2)OCO3)c(C)n1C.,Cc1c(C(=O)N2CCCCC2)c(S(=O)(=O)NCc2ccc3c(c2)OCO3)c(C)n1C,amine
+243734,Please remove a benzene_ring from the molecule Cc1ccnc(NC(=O)[C@H](Cc2ccccc2)N2C(=O)c3ccccc3C2=O)c1.,Cc1ccnc(NC(=O)[C@H](Cc2ccccc2)N2C(=O)c3ccccc3C2=O)c1,benzene_ring
+213350,Please remove a amide from the molecule NC(=O)[C@@H]1CN(C(=O)[C@@H]2CCC[NH+]2Cc2ccc(F)cc2)CCO1.,NC(=O)[C@@H]1CN(C(=O)[C@@H]2CCC[NH+]2Cc2ccc(F)cc2)CCO1,amide
+205260,Modify the molecule C[C@H]1CN([C@H](C)c2ccc(Cl)s2)C(=O)NC1=O by removing a amide.,C[C@H]1CN([C@H](C)c2ccc(Cl)s2)C(=O)NC1=O,amide
+22662,Please remove a halo from the molecule O=C(c1cnn2c1N[C@H](c1ccccc1)C[C@H]2C(F)(F)F)N1CC[NH+](Cc2ccccc2)CC1.,O=C(c1cnn2c1N[C@H](c1ccccc1)C[C@H]2C(F)(F)F)N1CC[NH+](Cc2ccccc2)CC1,halo
+121507,Remove a amide from the molecule CCOc1cccc(/C=N\NC(=O)[C@H]2COc3cc4ccccc4cc3O2)c1O.,CCOc1cccc(/C=N\NC(=O)[C@H]2COc3cc4ccccc4cc3O2)c1O,amide
+204892,Remove a amide from the molecule CC(C)c1nnnn1CC(=O)NCCc1ccc(N(C)C)cc1.,CC(C)c1nnnn1CC(=O)NCCc1ccc(N(C)C)cc1,amide
+53940,Modify the molecule COc1cc(OCC(=O)[C@H](C#N)c2ccc(F)cn2)ccc1[N+](=O)[O-] by removing a halo.,COc1cc(OCC(=O)[C@H](C#N)c2ccc(F)cn2)ccc1[N+](=O)[O-],halo
+19135,Please remove a amide from the molecule CCn1cc([C@H](NC(=O)CCC[NH3+])c2ccc(F)cc2)c2cc[nH+]cc21.,CCn1cc([C@H](NC(=O)CCC[NH3+])c2ccc(F)cc2)c2cc[nH+]cc21,amide
+35661,Remove a halo from the molecule CC(=O)c1sc(NC(=O)c2ccc(Cl)s2)nc1-c1ccccc1.,CC(=O)c1sc(NC(=O)c2ccc(Cl)s2)nc1-c1ccccc1,halo
+161331,Please remove a amine from the molecule N[C@H](Cc1ccccc1)C(=O)N1CCn2nc(CCC(=O)NC3CC3)cc2C1.,N[C@H](Cc1ccccc1)C(=O)N1CCn2nc(CCC(=O)NC3CC3)cc2C1,amine
+145256,Remove a benzene_ring from the molecule Cc1cccc(/C([O-])=N/S(=O)(=O)c2sc(C)nc2C)c1.,Cc1cccc(/C([O-])=N/S(=O)(=O)c2sc(C)nc2C)c1,benzene_ring
+221407,Please remove a amide from the molecule O=C1CC[C@]2(CCCN(c3cnccn3)C2)CN1CCc1c[nH]c[nH+]1.,O=C1CC[C@]2(CCCN(c3cnccn3)C2)CN1CCc1c[nH]c[nH+]1,amide
+103491,Please remove a benzene_ring from the molecule CCc1ccc(-c2n[nH]c(SCc3cc(=O)n4ccsc4n3)n2)cc1.,CCc1ccc(-c2n[nH]c(SCc3cc(=O)n4ccsc4n3)n2)cc1,benzene_ring
+135235,Modify the molecule C=CCSc1ccccc1NCc1ccc([O-])c[nH+]1 by removing a amine.,C=CCSc1ccccc1NCc1ccc([O-])c[nH+]1,amine
+176153,Remove a halo from the molecule O=C(Nc1cccc(Cl)c1)c1nnc([C@H]2CCCN(C(=O)c3cccc(F)c3)C2)s1.,O=C(Nc1cccc(Cl)c1)c1nnc([C@H]2CCCN(C(=O)c3cccc(F)c3)C2)s1,halo
+106789,Modify the molecule COC(=O)CCC(=O)NCC1CCN(c2cc[nH+]cc2)CC1 by removing a amide.,COC(=O)CCC(=O)NCC1CCN(c2cc[nH+]cc2)CC1,amide
+178759,Please remove a benzene_ring from the molecule CC(C)(C)c1nnc(C[NH+]2CCCC[C@@H]2CCc2ccccc2)o1.,CC(C)(C)c1nnc(C[NH+]2CCCC[C@@H]2CCc2ccccc2)o1,benzene_ring
+31381,Remove a hydroxyl from the molecule COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)[NH+](CC2CC2)CC[C@]314.,COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)[NH+](CC2CC2)CC[C@]314,hydroxyl
+52263,Modify the molecule CC[NH+](CC(=O)Nc1c(C)cc(C)cc1C)[C@H]1CCS(=O)(=O)C1 by removing a amide.,CC[NH+](CC(=O)Nc1c(C)cc(C)cc1C)[C@H]1CCS(=O)(=O)C1,amide
+136775,Please remove a amide from the molecule CNC(=O)c1cccc(NC(=O)C(=O)N[C@H]2CC[C@@H]([NH+](C)C)C2)c1C.,CNC(=O)c1cccc(NC(=O)C(=O)N[C@H]2CC[C@@H]([NH+](C)C)C2)c1C,amide
+101471,Modify the molecule C[NH2+][C@]1(CO)CCC[C@@H]([NH+]2C[C@@H](C)CC[C@H]2C)C1 by removing a hydroxyl.,C[NH2+][C@]1(CO)CCC[C@@H]([NH+]2C[C@@H](C)CC[C@H]2C)C1,hydroxyl
+215485,Modify the molecule COc1cc2c(cc1CN1CCO[C@@H](c3ccc(F)cc3)C1)OCCCO2 by removing a halo.,COc1cc2c(cc1CN1CCO[C@@H](c3ccc(F)cc3)C1)OCCCO2,halo
+141846,Please remove a benzene_ring from the molecule Cc1ccc(C(=O)N2CCN(C(=O)[C@H](C)Sc3ccccn3)CC2)cc1.,Cc1ccc(C(=O)N2CCN(C(=O)[C@H](C)Sc3ccccn3)CC2)cc1,benzene_ring
+76646,Please remove a amine from the molecule Cc1cccc(C)c1OCC(=O)/N=C1/NCCS1.,Cc1cccc(C)c1OCC(=O)/N=C1/NCCS1,amine
+155425,Modify the molecule O=c1oc(-c2cccs2)nn1CN1CCN(c2ncccc2F)CC1 by removing a halo.,O=c1oc(-c2cccs2)nn1CN1CCN(c2ncccc2F)CC1,halo
+58330,Please remove a halo from the molecule CC[NH2+][C@@H](c1ccc(F)c(F)c1)[C@H](C)OC.,CC[NH2+][C@@H](c1ccc(F)c(F)c1)[C@H](C)OC,halo
+89487,Modify the molecule COC(=O)[C@H](NC(=O)Cc1ccc(C)c(O)c1)C(C)(C)C by removing a hydroxyl.,COC(=O)[C@H](NC(=O)Cc1ccc(C)c(O)c1)C(C)(C)C,hydroxyl
+7318,Remove a amide from the molecule O=C(COC1CCCCC1)NC1CC[NH+](CCc2ccncc2)CC1.,O=C(COC1CCCCC1)NC1CC[NH+](CCc2ccncc2)CC1,amide
+4572,Modify the molecule Cc1nc2n(n1)C[C@@H]([NH2+]Cc1cn(-c3ccccc3)nn1)CC2 by removing a benzene_ring.,Cc1nc2n(n1)C[C@@H]([NH2+]Cc1cn(-c3ccccc3)nn1)CC2,benzene_ring
+229843,Please remove a halo from the molecule O=C(NCCCn1cccc1)c1c(F)cccc1Cl.,O=C(NCCCn1cccc1)c1c(F)cccc1Cl,halo
+183162,Remove a nitro from the molecule O=[N+]([O-])c1ccc(-c2nc(CN3CC[NH+]4CCCC[C@@H]4C3)co2)cc1.,O=[N+]([O-])c1ccc(-c2nc(CN3CC[NH+]4CCCC[C@@H]4C3)co2)cc1,nitro
+114270,Modify the molecule CCc1ccccc1CNC(=O)Nc1ccc(OC)cc1C by removing a benzene_ring.,CCc1ccccc1CNC(=O)Nc1ccc(OC)cc1C,benzene_ring
+34820,Modify the molecule Cc1cc([C@H](c2ccccc2Cl)N2CC[NH+](C)CC2)c(NC(=O)c2ccco2)s1 by removing a halo.,Cc1cc([C@H](c2ccccc2Cl)N2CC[NH+](C)CC2)c(NC(=O)c2ccco2)s1,halo
+864,Remove a hydroxyl from the molecule CS(=O)(=O)N1CCC[C@@H](C[NH+]2CCC[C@H](CO)C2)C1.,CS(=O)(=O)N1CCC[C@@H](C[NH+]2CCC[C@H](CO)C2)C1,hydroxyl
+43103,Please remove a amide from the molecule COc1ccccc1NC(=O)c1cc(S(=O)(=O)N2CCCC2)cn1C.,COc1ccccc1NC(=O)c1cc(S(=O)(=O)N2CCCC2)cn1C,amide
+79488,Please remove a halo from the molecule CCOC(=O)C1=C(CC)NC2=C(C(=O)CCC2)[C@@H]1c1ccccc1Cl.,CCOC(=O)C1=C(CC)NC2=C(C(=O)CCC2)[C@@H]1c1ccccc1Cl,halo
+11221,Please remove a halo from the molecule Cn1cc(C[NH+]2CCC[C@H](O)C2)c(-c2ccccc2F)n1.,Cn1cc(C[NH+]2CCC[C@H](O)C2)c(-c2ccccc2F)n1,halo
+204679,Modify the molecule CC(C)c1ccc(OCc2nnc(S)n2C)cc1 by removing a thiol.,CC(C)c1ccc(OCc2nnc(S)n2C)cc1,thiol
+211949,Modify the molecule Cc1ccc(C(=O)NCCCNC(=O)C(C)(C)C)cn1 by removing a amide.,Cc1ccc(C(=O)NCCCNC(=O)C(C)(C)C)cn1,amide
+129110,Remove a benzene_ring from the molecule CC1=CC=CC2=[NH+][C@@H](c3ccc(C)cc3)CN12.,CC1=CC=CC2=[NH+][C@@H](c3ccc(C)cc3)CN12,benzene_ring
+208864,Modify the molecule COCCN(C(C)=O)c1nc(Cn2nc(C(C)(C)C)ccc2=O)cs1 by removing a amide.,COCCN(C(C)=O)c1nc(Cn2nc(C(C)(C)C)ccc2=O)cs1,amide
+174868,Remove a halo from the molecule C[C@H](CC(=O)[O-])Sc1ccc(F)cc1.,C[C@H](CC(=O)[O-])Sc1ccc(F)cc1,halo
+216827,Please remove a nitro from the molecule C=CCN(C(=O)Cc1ccc(C)nc1)c1nc(-c2ccc([N+](=O)[O-])cc2)cs1.,C=CCN(C(=O)Cc1ccc(C)nc1)c1nc(-c2ccc([N+](=O)[O-])cc2)cs1,nitro
+231358,Remove a benzene_ring from the molecule CC(=O)Nc1cccc(NC(=O)c2ccc3c(c2)C(=O)N(CCCc2ccccc2)C3=O)c1.,CC(=O)Nc1cccc(NC(=O)c2ccc3c(c2)C(=O)N(CCCc2ccccc2)C3=O)c1,benzene_ring
+216266,Remove a benzene_ring from the molecule CCCSC[C@H]([NH3+])c1cc(OC)cc(OC)c1.,CCCSC[C@H]([NH3+])c1cc(OC)cc(OC)c1,benzene_ring
+84347,Please remove a halo from the molecule FC(F)(F)CCn1c(=S)[nH]c2cc(Br)cnc21.,FC(F)(F)CCn1c(=S)[nH]c2cc(Br)cnc21,halo
+127918,Modify the molecule CCn1ccnc1SCc1cccc(NC(=O)OC(C)(C)C)c1 by removing a benzene_ring.,CCn1ccnc1SCc1cccc(NC(=O)OC(C)(C)C)c1,benzene_ring
+132090,Modify the molecule C[C@H]1COC2(CCN(C(=O)NCC3(c4ccccc4)CCC3)CC2)O1 by removing a benzene_ring.,C[C@H]1COC2(CCN(C(=O)NCC3(c4ccccc4)CCC3)CC2)O1,benzene_ring
+12906,Modify the molecule C[C@@H](NC(=O)CSc1nnc(-c2ccc(F)cc2)o1)c1ccc2c(c1)CCCC2 by removing a benzene_ring.,C[C@@H](NC(=O)CSc1nnc(-c2ccc(F)cc2)o1)c1ccc2c(c1)CCCC2,benzene_ring
+58362,Please remove a benzene_ring from the molecule CC[C@@H](C)C(=O)CSc1nnc(-c2ccncc2)n1-c1ccccc1C.,CC[C@@H](C)C(=O)CSc1nnc(-c2ccncc2)n1-c1ccccc1C,benzene_ring
+218097,Remove a benzene_ring from the molecule CS[C@H]1CC[C@H](NC(=O)c2ccccc2OC2CCC2)C1.,CS[C@H]1CC[C@H](NC(=O)c2ccccc2OC2CCC2)C1,benzene_ring
+110659,Modify the molecule Cc1ccc2nc(S[C@@H](C)C(=O)Nc3nccs3)[nH]c2c1 by removing a amide.,Cc1ccc2nc(S[C@@H](C)C(=O)Nc3nccs3)[nH]c2c1,amide
+52081,Remove a amide from the molecule C[C@@H](c1nc2ccccc2s1)N1CC[NH+](CC(=O)N2CCCCC2)CC1.,C[C@@H](c1nc2ccccc2s1)N1CC[NH+](CC(=O)N2CCCCC2)CC1,amide
+62441,Please remove a amide from the molecule C[NH2+][C@]1(C(N)=O)CCC[C@H]1CCSC1CCOCC1.,C[NH2+][C@]1(C(N)=O)CCC[C@H]1CCSC1CCOCC1,amide
+191276,Please remove a amine from the molecule c1ccc2c(c1)OC[C@H]2CNCc1cc2c(s1)CCC2.,c1ccc2c(c1)OC[C@H]2CNCc1cc2c(s1)CCC2,amine
+237220,Please remove a benzene_ring from the molecule CCc1ccc([C@@H](C)NC(=O)[C@H](C)Oc2ccccc2)cc1.,CCc1ccc([C@@H](C)NC(=O)[C@H](C)Oc2ccccc2)cc1,benzene_ring
+240685,Modify the molecule CCOCCn1/c(=N/C(=O)Cc2cccs2)sc2cc(S(N)(=O)=O)ccc21 by removing a amine.,CCOCCn1/c(=N/C(=O)Cc2cccs2)sc2cc(S(N)(=O)=O)ccc21,amine
+45151,Modify the molecule NC(=O)[C@@H]1CCCN1C1CC[NH+](CCCNC(=O)C(F)(F)F)CC1 by removing a halo.,NC(=O)[C@@H]1CCCN1C1CC[NH+](CCCNC(=O)C(F)(F)F)CC1,halo
+149108,Please remove a halo from the molecule Cc1c([C@H](C)[NH2+]Cc2cnn(-c3ccccc3)c2)cnn1-c1cccc(F)c1.,Cc1c([C@H](C)[NH2+]Cc2cnn(-c3ccccc3)c2)cnn1-c1cccc(F)c1,halo
+110208,Remove a benzene_ring from the molecule Cc1ccc(C)c(S(=O)(=O)NCc2nc(-c3ccccc3)no2)c1.,Cc1ccc(C)c(S(=O)(=O)NCc2nc(-c3ccccc3)no2)c1,benzene_ring
+89346,Modify the molecule Cc1ccc(NC(=S)N2CCN(C/C=C/c3ccccc3)CC2)c(C)c1 by removing a amine.,Cc1ccc(NC(=S)N2CCN(C/C=C/c3ccccc3)CC2)c(C)c1,amine
+3520,Modify the molecule CC(C)(C)c1ccc(=O)n(CCCOc2ccc(F)cc2)n1 by removing a halo.,CC(C)(C)c1ccc(=O)n(CCCOc2ccc(F)cc2)n1,halo
+136916,Please remove a nitrile from the molecule COc1ccc(/C=C(\C#N)C(=O)N(C)C)c2ccccc12.,COc1ccc(/C=C(\C#N)C(=O)N(C)C)c2ccccc12,nitrile
+244571,Remove a benzene_ring from the molecule CCN(C(=O)[C@H]1C[C@H]2CC[C@@H]1O2)c1ccc(C)cc1C.,CCN(C(=O)[C@H]1C[C@H]2CC[C@@H]1O2)c1ccc(C)cc1C,benzene_ring
+185698,Modify the molecule O=C1N/C(=C\c2cn(Cc3ccc(F)cc3)c3ccccc23)C(=O)N1Cc1ccccc1F by removing a halo.,O=C1N/C(=C\c2cn(Cc3ccc(F)cc3)c3ccccc23)C(=O)N1Cc1ccccc1F,halo
+94684,Modify the molecule CC(C)(C)OC(=O)N1CC[C@H](COc2nc3cc([N+](=O)[O-])ccc3o2)C1 by removing a nitro.,CC(C)(C)OC(=O)N1CC[C@H](COc2nc3cc([N+](=O)[O-])ccc3o2)C1,nitro
+131461,Modify the molecule Cc1ccc(NC(=O)[C@H]2CC(=O)N(Cc3ccco3)C2)nc1 by removing a amide.,Cc1ccc(NC(=O)[C@H]2CC(=O)N(Cc3ccco3)C2)nc1,amide
+110896,Please remove a benzene_ring from the molecule COc1cccc(C[C@@H](C)NC(=O)c2ccccc2C(C)=O)c1.,COc1cccc(C[C@@H](C)NC(=O)c2ccccc2C(C)=O)c1,benzene_ring
+72728,Please remove a amine from the molecule Cc1ccc(N2C(=O)S[C@H](Nc3cccc(F)c3)C2=O)cc1C.,Cc1ccc(N2C(=O)S[C@H](Nc3cccc(F)c3)C2=O)cc1C,amine
+190903,Please remove a amide from the molecule O=C(c1ccc(N2CCCC2=O)cc1)N1CCC[C@@H](c2nc3ccccc3[nH]2)C1.,O=C(c1ccc(N2CCCC2=O)cc1)N1CCC[C@@H](c2nc3ccccc3[nH]2)C1,amide
+110633,Modify the molecule Cc1ccc2nc(N(C[C@@H]3CCCO3)C(=O)CCS(=O)(=O)c3ccccc3)sc2c1 by removing a benzene_ring.,Cc1ccc2nc(N(C[C@@H]3CCCO3)C(=O)CCS(=O)(=O)c3ccccc3)sc2c1,benzene_ring
+23946,Remove a amide from the molecule O=C(/C=C/c1ccc(O)cc1)NC[C@@H]1CC[C@H](C(=O)[O-])O1.,O=C(/C=C/c1ccc(O)cc1)NC[C@@H]1CC[C@H](C(=O)[O-])O1,amide
+186254,Remove a halo from the molecule CN1CCn2c([nH+]c3cc([N-]S(=O)(=O)c4ccc(Cl)cc4)ccc32)C1.,CN1CCn2c([nH+]c3cc([N-]S(=O)(=O)c4ccc(Cl)cc4)ccc32)C1,halo
+37472,Remove a amide from the molecule COC(=O)[C@@H]1CN(C(C)=O)C[C@@H]1C.,COC(=O)[C@@H]1CN(C(C)=O)C[C@@H]1C,amide
+143099,Modify the molecule COc1ccc(Cn2c(N)c3ccccc3nc2=S)cc1 by removing a amine.,COc1ccc(Cn2c(N)c3ccccc3nc2=S)cc1,amine
+75085,Modify the molecule CC(=O)N1CCC(C(=O)N2CCC(c3[nH+]ccn3Cc3ccccn3)CC2)CC1 by removing a amide.,CC(=O)N1CCC(C(=O)N2CCC(c3[nH+]ccn3Cc3ccccn3)CC2)CC1,amide
+150354,Remove a halo from the molecule Cc1cc2cc(CN3CCn4c(nnc4C(F)(F)F)C3)oc2cc1C.,Cc1cc2cc(CN3CCn4c(nnc4C(F)(F)F)C3)oc2cc1C,halo
+24244,Modify the molecule CC[C@H](C)[NH2+]Cc1ccccc1 by removing a benzene_ring.,CC[C@H](C)[NH2+]Cc1ccccc1,benzene_ring
+142155,Please remove a amide from the molecule Cc1ccc(NC(=O)C(=O)N2CCC([NH+]3CCCC3)CC2)c(Cl)n1.,Cc1ccc(NC(=O)C(=O)N2CCC([NH+]3CCCC3)CC2)c(Cl)n1,amide
+138494,Modify the molecule C[C@H](NC(=O)COc1ccccc1F)c1cccc(C#N)c1 by removing a nitrile.,C[C@H](NC(=O)COc1ccccc1F)c1cccc(C#N)c1,nitrile
+19342,Please remove a amide from the molecule C[C@@H]1[C@@H](C(=O)[O-])CCN1C(=O)[C@@H]1CCCN(C(N)=O)C1.,C[C@@H]1[C@@H](C(=O)[O-])CCN1C(=O)[C@@H]1CCCN(C(N)=O)C1,amide
+88720,Remove a amide from the molecule O=C1C[C@H](C(=O)Nc2ccc(F)cc2F)[C@@H]2C(=O)N=C(SCc3ccccc3F)N=C2N1.,O=C1C[C@H](C(=O)Nc2ccc(F)cc2F)[C@@H]2C(=O)N=C(SCc3ccccc3F)N=C2N1,amide
+82825,Please remove a benzene_ring from the molecule CC(C)COC(=O)c1ccc(NC(=O)[C@H]2[C@@H](C(=O)[O-])[C@@H]3C=C[C@H]2C3)cc1.,CC(C)COC(=O)c1ccc(NC(=O)[C@H]2[C@@H](C(=O)[O-])[C@@H]3C=C[C@H]2C3)cc1,benzene_ring
+235033,Please remove a benzene_ring from the molecule CCc1ccc(NC(=O)c2cc(OC)no2)cc1.,CCc1ccc(NC(=O)c2cc(OC)no2)cc1,benzene_ring
+39461,Please remove a benzene_ring from the molecule CC[C@@H](C)NS(=O)(=O)c1ccc(NC(=O)c2ccc(C)c(Br)c2)cc1.,CC[C@@H](C)NS(=O)(=O)c1ccc(NC(=O)c2ccc(C)c(Br)c2)cc1,benzene_ring
+172472,Modify the molecule CCN(CC)C(=O)c1cccc(S(=O)(=O)NC2CC2)c1 by removing a amine.,CCN(CC)C(=O)c1cccc(S(=O)(=O)NC2CC2)c1,amine
+58454,Please remove a benzene_ring from the molecule Cc1cc(C)c(C)c(S(=O)(=O)N2CCC([NH+]3CCCCC3)CC2)c1C.,Cc1cc(C)c(C)c(S(=O)(=O)N2CCC([NH+]3CCCCC3)CC2)c1C,benzene_ring
+208313,Please remove a benzene_ring from the molecule C[C@H](NC(=O)c1ccc(N)cc1)C(=O)[O-].,C[C@H](NC(=O)c1ccc(N)cc1)C(=O)[O-],benzene_ring
+246370,Modify the molecule Cc1cc(C)cc(C[C@H]([NH3+])CSc2ccccc2Cl)c1 by removing a halo.,Cc1cc(C)cc(C[C@H]([NH3+])CSc2ccccc2Cl)c1,halo
+222631,Remove a benzene_ring from the molecule COc1ccccc1[C@@H](CNC(=O)N1CC[C@@H]([N+]2=CCCC2)C1)[NH+](C)C.,COc1ccccc1[C@@H](CNC(=O)N1CC[C@@H]([N+]2=CCCC2)C1)[NH+](C)C,benzene_ring
+201378,Modify the molecule CCN(CC)C(=O)Cn1cc(Br)c(=O)[nH]c1=O by removing a amide.,CCN(CC)C(=O)Cn1cc(Br)c(=O)[nH]c1=O,amide
+111072,Modify the molecule O=C(Nc1ccc(-c2nccs2)cc1)c1ccccc1I by removing a halo.,O=C(Nc1ccc(-c2nccs2)cc1)c1ccccc1I,halo
+19937,Modify the molecule CC(=O)N1CCC(C(=O)N2CCOC[C@@H]2C[NH+](C)C)CC1 by removing a amide.,CC(=O)N1CCC(C(=O)N2CCOC[C@@H]2C[NH+](C)C)CC1,amide
+38838,Please remove a halo from the molecule CN(Cc1cnn(-c2ccccc2)c1)S(=O)(=O)c1cccc(OC(F)(F)F)c1.,CN(Cc1cnn(-c2ccccc2)c1)S(=O)(=O)c1cccc(OC(F)(F)F)c1,halo
+170865,Modify the molecule CNC(=O)Cc1noc(-c2coc3ccccc23)n1 by removing a amide.,CNC(=O)Cc1noc(-c2coc3ccccc23)n1,amide
+23086,Remove a benzene_ring from the molecule CCc1nc(C)c([C@H](C)OC(=O)Cc2ccc(N3CCCC3=O)cc2)s1.,CCc1nc(C)c([C@H](C)OC(=O)Cc2ccc(N3CCCC3=O)cc2)s1,benzene_ring
+53632,Remove a amine from the molecule CCC[NH+](C1CC1)C1(CN)CCN(C(C)C)CC1.,CCC[NH+](C1CC1)C1(CN)CCN(C(C)C)CC1,amine
+202236,Remove a benzene_ring from the molecule COc1ccc(C[C@H](C)CNC(=O)c2ccc(C(N)=O)cn2)cc1.,COc1ccc(C[C@H](C)CNC(=O)c2ccc(C(N)=O)cn2)cc1,benzene_ring
+136578,Modify the molecule COc1ccc(CNC(=O)[C@H]2CCCN(C(=O)NC3CC3)C2)cc1 by removing a amide.,COc1ccc(CNC(=O)[C@H]2CCCN(C(=O)NC3CC3)C2)cc1,amide
+3096,Remove a halo from the molecule O=C(N=c1[nH]c2ccccc2[nH]1)c1cc(Cl)ccc1[N+](=O)[O-].,O=C(N=c1[nH]c2ccccc2[nH]1)c1cc(Cl)ccc1[N+](=O)[O-],halo
+211253,Please remove a amine from the molecule C[C@@H]1CCC[C@](CO)(Nc2nc3cc(N)ccc3o2)C1.,C[C@@H]1CCC[C@](CO)(Nc2nc3cc(N)ccc3o2)C1,amine
+218387,Remove a benzene_ring from the molecule NC(=O)N1CCC[C@@H](C(=O)Nc2ccccc2C(=O)NCC(F)(F)F)C1.,NC(=O)N1CCC[C@@H](C(=O)Nc2ccccc2C(=O)NCC(F)(F)F)C1,benzene_ring
+24420,Remove a hydroxyl from the molecule CC1(C)CC(NC(=O)N2CCN(C(=O)c3ccc(O)cc3)CC2)CC(C)(C)[NH2+]1.,CC1(C)CC(NC(=O)N2CCN(C(=O)c3ccc(O)cc3)CC2)CC(C)(C)[NH2+]1,hydroxyl
+216438,Please remove a amide from the molecule Cc1ccccc1-n1cc(CN(C)C(=O)[C@H]2CCCCC[NH+]2C)cn1.,Cc1ccccc1-n1cc(CN(C)C(=O)[C@H]2CCCCC[NH+]2C)cn1,amide
+77743,Remove a halo from the molecule COc1ccc(-n2c(N)c(C(=O)Nc3cccc(F)c3)sc2=S)c(OC)c1.,COc1ccc(-n2c(N)c(C(=O)Nc3cccc(F)c3)sc2=S)c(OC)c1,halo
+241348,Please remove a benzene_ring from the molecule Cc1nc(C)c(C(=O)Nc2cccc(NC(=O)NCc3ccncc3)c2)o1.,Cc1nc(C)c(C(=O)Nc2cccc(NC(=O)NCc3ccncc3)c2)o1,benzene_ring
+162563,Remove a amine from the molecule Cc1ccc(C)c(S(=O)(=O)NCCNC(=O)[C@H](C)c2cccs2)c1.,Cc1ccc(C)c(S(=O)(=O)NCCNC(=O)[C@H](C)c2cccs2)c1,amine
+41279,Modify the molecule C[C@@H](NC(=O)[C@H]1CCCN(C(=O)c2ccc(Cl)cc2)C1)c1ccccc1Br by removing a halo.,C[C@@H](NC(=O)[C@H]1CCCN(C(=O)c2ccc(Cl)cc2)C1)c1ccccc1Br,halo
+35500,Remove a amide from the molecule Cn1cc[nH+]c1CNC(=O)CCc1cc(Cl)ccc1Br.,Cn1cc[nH+]c1CNC(=O)CCc1cc(Cl)ccc1Br,amide
+196774,Remove a benzene_ring from the molecule COc1cc(C=O)cc(Cl)c1O[C@@H](C)[C@H](C)O.,COc1cc(C=O)cc(Cl)c1O[C@@H](C)[C@H](C)O,benzene_ring
+49781,Please remove a halo from the molecule Cc1cc(NC(=O)[C@@H]2C[C@@H]2c2ccccc2)n(-c2ccc(F)cc2)n1.,Cc1cc(NC(=O)[C@@H]2C[C@@H]2c2ccccc2)n(-c2ccc(F)cc2)n1,halo
+21157,Modify the molecule C[C@@H]1C(=O)N2CCCc3cc(NC(=O)C(=O)NCC4(c5cccs5)CCOCC4)cc1c32 by removing a amide.,C[C@@H]1C(=O)N2CCCc3cc(NC(=O)C(=O)NCC4(c5cccs5)CCOCC4)cc1c32,amide
+207085,Remove a benzene_ring from the molecule COCC1CCN(C(=O)N[C@H]2CCCN(c3ccc(C)cc3)C2=O)CC1.,COCC1CCN(C(=O)N[C@H]2CCCN(c3ccc(C)cc3)C2=O)CC1,benzene_ring
+86481,Remove a benzene_ring from the molecule CC[C@H](C)NC(=O)N1CCN(Cc2cc(OC)cc(OC)c2)CC1.,CC[C@H](C)NC(=O)N1CCN(Cc2cc(OC)cc(OC)c2)CC1,benzene_ring
+24080,Modify the molecule N#Cc1ccc(N2CCN(C(=O)CCc3n[nH]c4c3CCCC4)CC2=O)cc1 by removing a benzene_ring.,N#Cc1ccc(N2CCN(C(=O)CCc3n[nH]c4c3CCCC4)CC2=O)cc1,benzene_ring
+33657,Modify the molecule O=C(N/N=C\c1ccccc1Br)c1ccc(O)cc1O by removing a benzene_ring.,O=C(N/N=C\c1ccccc1Br)c1ccc(O)cc1O,benzene_ring
+117403,Remove a amide from the molecule CCOc1ccc(C(=O)Nc2ccnc(C(=O)N(C)C)c2)cc1.,CCOc1ccc(C(=O)Nc2ccnc(C(=O)N(C)C)c2)cc1,amide
+60726,Remove a amide from the molecule O=C(NCC(=O)N1CC[C@@H]2CCCC[C@H]21)c1cc2ccccc2[nH]1.,O=C(NCC(=O)N1CC[C@@H]2CCCC[C@H]21)c1cc2ccccc2[nH]1,amide
+191143,Modify the molecule CSC(=S)N(C)NC(=O)c1ncccn1 by removing a amide.,CSC(=S)N(C)NC(=O)c1ncccn1,amide
+151907,Modify the molecule C[NH+]1CCN(C(C)(C)C(=O)NCC2(c3ccc(F)cc3)CCC2)CC1 by removing a amide.,C[NH+]1CCN(C(C)(C)C(=O)NCC2(c3ccc(F)cc3)CCC2)CC1,amide
+215593,Please remove a hydroxyl from the molecule CC[C@@H](C)[C@@](C)(O)C[NH2+]Cc1ncc(-c2ccccc2)s1.,CC[C@@H](C)[C@@](C)(O)C[NH2+]Cc1ncc(-c2ccccc2)s1,hydroxyl
+79834,Remove a benzene_ring from the molecule COc1cc(Cl)c(C)cc1NC(=O)N[C@@H]1CC[C@H]([NH+](C)C)C1.,COc1cc(Cl)c(C)cc1NC(=O)N[C@@H]1CC[C@H]([NH+](C)C)C1,benzene_ring
+54444,Remove a amine from the molecule CCc1cc2c(N[C@@H](C)c3cccc(S(=O)(=O)NC)c3)ncnc2s1.,CCc1cc2c(N[C@@H](C)c3cccc(S(=O)(=O)NC)c3)ncnc2s1,amine
+178302,Please remove a amine from the molecule CCOCCCC(=O)N1c2ccc(N)cc2C[C@H]1C.,CCOCCCC(=O)N1c2ccc(N)cc2C[C@H]1C,amine
+59094,Remove a halo from the molecule CCc1nn(C)cc1NS(=O)(=O)c1ccc([N+](=O)[O-])cc1Cl.,CCc1nn(C)cc1NS(=O)(=O)c1ccc([N+](=O)[O-])cc1Cl,halo
+75952,Remove a benzene_ring from the molecule Cc1cccc(OCC(=O)Nc2ccc3c(c2)nc(C[NH+]2CCCCC2)n3C)c1.,Cc1cccc(OCC(=O)Nc2ccc3c(c2)nc(C[NH+]2CCCCC2)n3C)c1,benzene_ring
+51045,Remove a amine from the molecule Cc1nccc(N[C@H](C)CCC[NH3+])n1.,Cc1nccc(N[C@H](C)CCC[NH3+])n1,amine
+6391,Remove a halo from the molecule O=C(CNC(=O)c1ccoc1)Nc1cc(C(F)(F)F)c[nH]c1=O.,O=C(CNC(=O)c1ccoc1)Nc1cc(C(F)(F)F)c[nH]c1=O,halo
+97168,Modify the molecule CCn1ncnc1-c1c(-c2ccccc2)ncn1[C@@H](C)Cc1cc(C)n[nH]1 by removing a benzene_ring.,CCn1ncnc1-c1c(-c2ccccc2)ncn1[C@@H](C)Cc1cc(C)n[nH]1,benzene_ring
+67065,Please remove a amide from the molecule C[C@@](O)(CNC(=O)CC1([NH3+])CCC1)C(=O)[O-].,C[C@@](O)(CNC(=O)CC1([NH3+])CCC1)C(=O)[O-],amide
+117954,Remove a benzene_ring from the molecule Cc1ccc(S(=O)(=O)N2CCN(C(=O)C[NH2+][C@@H](C)c3cccc(F)c3)CC2)cc1.,Cc1ccc(S(=O)(=O)N2CCN(C(=O)C[NH2+][C@@H](C)c3cccc(F)c3)CC2)cc1,benzene_ring
+92208,Modify the molecule C=CCN(CC(=O)[O-])C(=O)C1C[NH2+]C1 by removing a amide.,C=CCN(CC(=O)[O-])C(=O)C1C[NH2+]C1,amide
+100696,Please remove a amide from the molecule O=C1[C@H]2C[C@@H](Br)[C@H](Br)C[C@@H]2C(=O)N1c1ccc(Cl)cc1.,O=C1[C@H]2C[C@@H](Br)[C@H](Br)C[C@@H]2C(=O)N1c1ccc(Cl)cc1,amide
+108658,Modify the molecule Fc1ccc(-n2ncc3c(N4CCCc5ccccc54)ncnc32)cc1 by removing a halo.,Fc1ccc(-n2ncc3c(N4CCCc5ccccc54)ncnc32)cc1,halo
+61829,Please remove a halo from the molecule Cc1nn(CC[C@H]2CCC[C@]2(CO)[NH2+]C2CC2)c(C)c1Cl.,Cc1nn(CC[C@H]2CCC[C@]2(CO)[NH2+]C2CC2)c(C)c1Cl,halo
+9987,Remove a benzene_ring from the molecule CCNc1nc(NCC)nc(Nc2ccc(C)c(C)c2)n1.,CCNc1nc(NCC)nc(Nc2ccc(C)c(C)c2)n1,benzene_ring
+1626,Remove a benzene_ring from the molecule CC[C@H](C(=O)Nc1cccc(CS(=O)(=O)c2ccccc2)c1)c1ccccc1.,CC[C@H](C(=O)Nc1cccc(CS(=O)(=O)c2ccccc2)c1)c1ccccc1,benzene_ring
+189635,Remove a amide from the molecule CC(C)[C@H](C)NC(=O)CS(=O)(=O)[C@@H](C)C(C)C.,CC(C)[C@H](C)NC(=O)CS(=O)(=O)[C@@H](C)C(C)C,amide
+89313,Modify the molecule Cn1/c(=N/C(=O)c2ccccc2O)[nH]c2cc(Cl)ccc21 by removing a hydroxyl.,Cn1/c(=N/C(=O)c2ccccc2O)[nH]c2cc(Cl)ccc21,hydroxyl
+203983,Modify the molecule N#C[C@@H](CCl)C[C@H]1COc2ccccc21 by removing a halo.,N#C[C@@H](CCl)C[C@H]1COc2ccccc21,halo
+93111,Modify the molecule Cc1ccc(-n2nnc(C(=O)NCc3ccccc3)c2C(C)C)cc1 by removing a benzene_ring.,Cc1ccc(-n2nnc(C(=O)NCc3ccccc3)c2C(C)C)cc1,benzene_ring
+21012,Remove a amide from the molecule O=C(C1CCN(C[C@@H]2CCC[NH+]3CCCC[C@@H]23)CC1)N1CCCC1.,O=C(C1CCN(C[C@@H]2CCC[NH+]3CCCC[C@@H]23)CC1)N1CCCC1,amide
+52598,Modify the molecule CC[NH+]1CC[C@H](N(C)Cc2cccc(C(F)(F)F)c2)[C@H](C)C1 by removing a benzene_ring.,CC[NH+]1CC[C@H](N(C)Cc2cccc(C(F)(F)F)c2)[C@H](C)C1,benzene_ring
+186516,Please remove a benzene_ring from the molecule CC(=O)N[C@@H](CC(=O)N(C)CC(=O)Nc1c(C)cccc1C)c1ccc(C)cc1.,CC(=O)N[C@@H](CC(=O)N(C)CC(=O)Nc1c(C)cccc1C)c1ccc(C)cc1,benzene_ring
+229852,Modify the molecule COC(=O)[C@H](C)CN(Cc1ccccc1)C(=O)c1ccc2n[nH]c(=O)n2c1 by removing a benzene_ring.,COC(=O)[C@H](C)CN(Cc1ccccc1)C(=O)c1ccc2n[nH]c(=O)n2c1,benzene_ring
+161951,Modify the molecule CCOC(=O)C1CC[NH+]([C@H](C)C(=O)Nc2cccc(C#N)c2)CC1 by removing a amide.,CCOC(=O)C1CC[NH+]([C@H](C)C(=O)Nc2cccc(C#N)c2)CC1,amide
+171258,Remove a benzene_ring from the molecule CC[C@H](C)Sc1cccc(F)c1C(N)=[NH2+].,CC[C@H](C)Sc1cccc(F)c1C(N)=[NH2+],benzene_ring
+88727,Remove a halo from the molecule CC(C)(C)Oc1ccc(Cl)cc1Br.,CC(C)(C)Oc1ccc(Cl)cc1Br,halo
+150038,Please remove a benzene_ring from the molecule CCn1nnc(NCc2ccc(C)cc2)n1.,CCn1nnc(NCc2ccc(C)cc2)n1,benzene_ring
+72188,Remove a halo from the molecule COc1ccc(-c2nnc(NC(=O)c3ccc(Cl)cc3)o2)cc1OC.,COc1ccc(-c2nnc(NC(=O)c3ccc(Cl)cc3)o2)cc1OC,halo
+117919,Please remove a nitrile from the molecule C[C@H](CC#N)[NH+](C)Cc1ccc(Cl)o1.,C[C@H](CC#N)[NH+](C)Cc1ccc(Cl)o1,nitrile
+125903,Modify the molecule Cc1csc(/C(C#N)=C/c2ccccc2OCC(=O)Nc2ccccc2)n1 by removing a nitrile.,Cc1csc(/C(C#N)=C/c2ccccc2OCC(=O)Nc2ccccc2)n1,nitrile
+77399,Please remove a amine from the molecule COc1ccnc(Nc2ccc(N(C)C)[nH+]c2)n1.,COc1ccnc(Nc2ccc(N(C)C)[nH+]c2)n1,amine
+177129,Modify the molecule COc1ccc(N[C@H](C)C2CC2)cc1F by removing a benzene_ring.,COc1ccc(N[C@H](C)C2CC2)cc1F,benzene_ring
+38802,Modify the molecule Cc1ccc(NC(=O)NCc2ccccc2S(=O)(=O)N(C)C)cc1 by removing a benzene_ring.,Cc1ccc(NC(=O)NCc2ccccc2S(=O)(=O)N(C)C)cc1,benzene_ring
+242184,Modify the molecule Cc1cccc(NC(=O)C(=O)N/N=C/c2cc([N+](=O)[O-])ccc2[O-])c1C by removing a amide.,Cc1cccc(NC(=O)C(=O)N/N=C/c2cc([N+](=O)[O-])ccc2[O-])c1C,amide
+159594,Remove a nitro from the molecule Cc1ccc(C[C@@H](C)Nc2ccc([N+](=O)[O-])cc2S(N)(=O)=O)c(C)c1.,Cc1ccc(C[C@@H](C)Nc2ccc([N+](=O)[O-])cc2S(N)(=O)=O)c(C)c1,nitro
+158945,Modify the molecule CC(C)(C)n1cc(CN2CCN(CC#N)CC2)c(-c2ccccc2Cl)n1 by removing a benzene_ring.,CC(C)(C)n1cc(CN2CCN(CC#N)CC2)c(-c2ccccc2Cl)n1,benzene_ring
+175829,Modify the molecule Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1cc(C)n(C2CC2)c1C by removing a amide.,Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1cc(C)n(C2CC2)c1C,amide
+207131,Please remove a amide from the molecule CC[C@H](C)OCC(=O)Nc1cn(C)nc1-c1ccccc1.,CC[C@H](C)OCC(=O)Nc1cn(C)nc1-c1ccccc1,amide
+219008,Modify the molecule CCn1cc(C(=O)NC[C@H](c2ccc(F)cc2)[NH+](C)C)cn1 by removing a halo.,CCn1cc(C(=O)NC[C@H](c2ccc(F)cc2)[NH+](C)C)cn1,halo
+21903,Modify the molecule O=[N+]([O-])c1ccccc1NCc1cn(-c2ccccc2)nn1 by removing a benzene_ring.,O=[N+]([O-])c1ccccc1NCc1cn(-c2ccccc2)nn1,benzene_ring
+86340,Modify the molecule Cc1ccsc1C(=O)N[C@@H](CC(C)C)C(=O)N(C)C by removing a amide.,Cc1ccsc1C(=O)N[C@@H](CC(C)C)C(=O)N(C)C,amide
+164156,Remove a halo from the molecule CN(Cc1cnn(C)c1)S(=O)(=O)c1cc(Cl)c(Cl)cc1Cl.,CN(Cc1cnn(C)c1)S(=O)(=O)c1cc(Cl)c(Cl)cc1Cl,halo
+11262,Please remove a benzene_ring from the molecule CCCC(=O)N1CCN(c2ccc(NC(=O)COc3ccc(C)cc3)cc2)CC1.,CCCC(=O)N1CCN(c2ccc(NC(=O)COc3ccc(C)cc3)cc2)CC1,benzene_ring
+200465,Modify the molecule COc1ccc2c(c1)[C@]1(CCN(C(=O)CC(C)C)C1)C(=O)N2 by removing a amide.,COc1ccc2c(c1)[C@]1(CCN(C(=O)CC(C)C)C1)C(=O)N2,amide
+73855,Modify the molecule CC[NH+](CC)c1ccc(NC(=O)[C@H](C)Oc2ccc(C)cc2C)cc1 by removing a amide.,CC[NH+](CC)c1ccc(NC(=O)[C@H](C)Oc2ccc(C)cc2C)cc1,amide
+6538,Modify the molecule CC[C@H](Cc1ccc(C)cc1)N(C)C(=O)Cc1nc2nc(C)cc(C)n2n1 by removing a amide.,CC[C@H](Cc1ccc(C)cc1)N(C)C(=O)Cc1nc2nc(C)cc(C)n2n1,amide
+26912,Modify the molecule C[C@H]1CC(C(=O)N2CCCSc3ccc(Cl)cc32)C[C@@H](C)O1 by removing a amide.,C[C@H]1CC(C(=O)N2CCCSc3ccc(Cl)cc32)C[C@@H](C)O1,amide
+81715,Modify the molecule CCS(=O)(=O)CCNC(=O)N[C@@H](c1ccccc1)c1ccccn1 by removing a benzene_ring.,CCS(=O)(=O)CCNC(=O)N[C@@H](c1ccccc1)c1ccccn1,benzene_ring
+138847,Remove a amine from the molecule Nc1nc(CCNC(=O)c2ccc(C[NH+]3CCCCC3)cc2)cs1.,Nc1nc(CCNC(=O)c2ccc(C[NH+]3CCCCC3)cc2)cs1,amine
+194256,Remove a benzene_ring from the molecule COc1ccc(C[NH+]2C[C@@H]3CC[C@H](C2)N(C(=O)c2oc(C)nc2C)C3)cc1.,COc1ccc(C[NH+]2C[C@@H]3CC[C@H](C2)N(C(=O)c2oc(C)nc2C)C3)cc1,benzene_ring
+45504,Remove a benzene_ring from the molecule CCOc1cc(NCc2ccc(C(=O)OC)o2)ccc1C.,CCOc1cc(NCc2ccc(C(=O)OC)o2)ccc1C,benzene_ring
+101414,Remove a nitro from the molecule CN(CCc1ccccc1Cl)c1ncc([N+](=O)[O-])s1.,CN(CCc1ccccc1Cl)c1ncc([N+](=O)[O-])s1,nitro
+8747,Modify the molecule COc1ccc(NC(=O)[C@H]2[C@@H]3C(=O)N(c4cc(C)on4)C[C@]34C=C[C@H]2O4)cc1 by removing a benzene_ring.,COc1ccc(NC(=O)[C@H]2[C@@H]3C(=O)N(c4cc(C)on4)C[C@]34C=C[C@H]2O4)cc1,benzene_ring
+239180,Remove a benzene_ring from the molecule CC(C)CCN(CC(=O)N1CCNCC1)C(=O)c1cccc(Cl)c1.,CC(C)CCN(CC(=O)N1CCNCC1)C(=O)c1cccc(Cl)c1,benzene_ring
+68048,Please remove a benzene_ring from the molecule COc1cn(-c2ccccc2)nc1C(=O)OCC(=O)N1CCCCC1.,COc1cn(-c2ccccc2)nc1C(=O)OCC(=O)N1CCCCC1,benzene_ring
+38874,Modify the molecule COc1ccc(C(=O)OCC(=O)NCc2cccc(C)c2)cc1 by removing a benzene_ring.,COc1ccc(C(=O)OCC(=O)NCc2cccc(C)c2)cc1,benzene_ring
+137039,Remove a benzene_ring from the molecule CC1(CNC(=O)CNC(=O)c2ccc(F)c(F)c2)CCCC1.,CC1(CNC(=O)CNC(=O)c2ccc(F)c(F)c2)CCCC1,benzene_ring
+135911,Remove a benzene_ring from the molecule Cc1ccccc1NC(=O)NCc1cn(-c2ccccc2)nc1-c1ccncc1.,Cc1ccccc1NC(=O)NCc1cn(-c2ccccc2)nc1-c1ccncc1,benzene_ring
+13859,Modify the molecule CCc1cccc(C)c1NC(=O)NCC1CC1 by removing a benzene_ring.,CCc1cccc(C)c1NC(=O)NCC1CC1,benzene_ring
+236810,Remove a benzene_ring from the molecule C[C@@H]1CCCCN1C(=O)NCc1ccc(F)c(Cl)c1.,C[C@@H]1CCCCN1C(=O)NCc1ccc(F)c(Cl)c1,benzene_ring
+144829,Modify the molecule O=C(CCC(=O)N1CCC(c2nc3ccccc3s2)CC1)c1ccc2ccccc2c1 by removing a amide.,O=C(CCC(=O)N1CCC(c2nc3ccccc3s2)CC1)c1ccc2ccccc2c1,amide
+191684,Please remove a amide from the molecule O=C(Cc1ccc2c(c1)OCO2)N1CCC[C@H]1c1nc(-c2ccccn2)no1.,O=C(Cc1ccc2c(c1)OCO2)N1CCC[C@H]1c1nc(-c2ccccn2)no1,amide
+105797,Remove a benzene_ring from the molecule Cc1cccc(OCCn2cnc3ccc(Cl)cc3c2=O)c1.,Cc1cccc(OCCn2cnc3ccc(Cl)cc3c2=O)c1,benzene_ring
+235339,Please remove a amide from the molecule O=C(CC1CCCCC1)NCc1nc2ccccc2[nH]1.,O=C(CC1CCCCC1)NCc1nc2ccccc2[nH]1,amide
+21939,Remove a nitro from the molecule N#Cc1cc([N+](=O)[O-])ccc1Sc1nc(-c2ccccc2F)n[nH]1.,N#Cc1cc([N+](=O)[O-])ccc1Sc1nc(-c2ccccc2F)n[nH]1,nitro
+96538,Remove a benzene_ring from the molecule CCOC(=O)c1cnc(-n2nc(C)cc2C)nc1Nc1ccc(C)c(C)c1.,CCOC(=O)c1cnc(-n2nc(C)cc2C)nc1Nc1ccc(C)c(C)c1,benzene_ring
+204050,Please remove a benzene_ring from the molecule O=C1[C@@H]2ON(c3ccccc3)[C@@H](c3cccs3)[C@H]2C(=O)N1c1ccccc1.,O=C1[C@@H]2ON(c3ccccc3)[C@@H](c3cccs3)[C@H]2C(=O)N1c1ccccc1,benzene_ring
+159839,Modify the molecule CCC[NH2+][C@](C)(CN1C[C@@H]2CCCC[NH+]2C[C@@H]1C)C(N)=O by removing a amide.,CCC[NH2+][C@](C)(CN1C[C@@H]2CCCC[NH+]2C[C@@H]1C)C(N)=O,amide
+131690,Remove a halo from the molecule CC(=O)N1CCC([NH2+][C@H](CC(F)(F)F)c2ccc(F)cc2)CC1.,CC(=O)N1CCC([NH2+][C@H](CC(F)(F)F)c2ccc(F)cc2)CC1,halo
+17245,Please remove a benzene_ring from the molecule COc1cccc(OC)c1C(=O)Nc1ccc(C(=O)NC[C@@H]2CCCO2)cc1.,COc1cccc(OC)c1C(=O)Nc1ccc(C(=O)NC[C@@H]2CCCO2)cc1,benzene_ring
+217892,Modify the molecule Cc1noc(C)c1S(=O)(=O)N1CCC[C@@H](C(=O)Nc2ccc3ncn(C)c3c2)C1 by removing a amide.,Cc1noc(C)c1S(=O)(=O)N1CCC[C@@H](C(=O)Nc2ccc3ncn(C)c3c2)C1,amide
+140597,Modify the molecule COc1ccc(Cl)c(NC(=O)[C@@H]2CC(O)=Nc3nncn32)c1 by removing a amide.,COc1ccc(Cl)c(NC(=O)[C@@H]2CC(O)=Nc3nncn32)c1,amide
+181971,Remove a benzene_ring from the molecule COc1cc(OC)c(NS(=O)(=O)c2cc(C(=O)N3CCC3)ccc2C)cc1Cl.,COc1cc(OC)c(NS(=O)(=O)c2cc(C(=O)N3CCC3)ccc2C)cc1Cl,benzene_ring
+242948,Modify the molecule CC[C@@H](NC(=O)NCCS(=O)(=O)C(C)(C)C)c1ccc(C)c(F)c1 by removing a halo.,CC[C@@H](NC(=O)NCCS(=O)(=O)C(C)(C)C)c1ccc(C)c(F)c1,halo
+43857,Remove a amide from the molecule COc1ccc(OC)c(CN2CCN(C(=O)C[C@H](C)c3ccccc3)CC2)c1.,COc1ccc(OC)c(CN2CCN(C(=O)C[C@H](C)c3ccccc3)CC2)c1,amide
+140570,Modify the molecule CC(=O)c1cccc(NC(=O)N2CCC[C@@H]2c2nnc3ccccn23)c1 by removing a benzene_ring.,CC(=O)c1cccc(NC(=O)N2CCC[C@@H]2c2nnc3ccccn23)c1,benzene_ring
+126481,Please remove a benzene_ring from the molecule COCc1ccc(C(=O)Nc2nc(-c3cccc(C(F)(F)F)c3)cs2)cc1.,COCc1ccc(C(=O)Nc2nc(-c3cccc(C(F)(F)F)c3)cs2)cc1,benzene_ring
+71990,Please remove a hydroxyl from the molecule Cc1cc(NC(=O)/C=C/c2ccco2)cc(C(=O)[O-])c1O.,Cc1cc(NC(=O)/C=C/c2ccco2)cc(C(=O)[O-])c1O,hydroxyl
+79050,Modify the molecule CC(C)(NC(=O)[C@@H]1CCC(=O)N(C2CCCC2)C1)C12CC3CC(CC(C3)C1)C2 by removing a amide.,CC(C)(NC(=O)[C@@H]1CCC(=O)N(C2CCCC2)C1)C12CC3CC(CC(C3)C1)C2,amide
+234522,Please remove a amide from the molecule NC(=O)c1ccc(C(=O)Oc2ccc(N3CCCC3)cc2)cn1.,NC(=O)c1ccc(C(=O)Oc2ccc(N3CCCC3)cc2)cn1,amide
+46313,Modify the molecule Fc1cccc(Cl)c1CSC1=N[C@@H]2CCCC[C@@H]2N1 by removing a amine.,Fc1cccc(Cl)c1CSC1=N[C@@H]2CCCC[C@@H]2N1,amine
+77890,Modify the molecule NC(=O)c1ccc(NC(=O)COC(=O)c2c3c(nc4ccccc24)/C(=C/c2ccc(O)cc2)CC3)cc1 by removing a benzene_ring.,NC(=O)c1ccc(NC(=O)COC(=O)c2c3c(nc4ccccc24)/C(=C/c2ccc(O)cc2)CC3)cc1,benzene_ring
+25236,Modify the molecule C[C@H]1C[C@@H](C)CN(C(=O)C[NH+](CCC#N)CC(C)(C)C)C1 by removing a amide.,C[C@H]1C[C@@H](C)CN(C(=O)C[NH+](CCC#N)CC(C)(C)C)C1,amide
+120649,Remove a benzene_ring from the molecule O=C(CCS(=O)(=O)c1ccccc1)N1CCN(c2nc3ccc(OC(F)(F)F)cc3s2)CC1.,O=C(CCS(=O)(=O)c1ccccc1)N1CCN(c2nc3ccc(OC(F)(F)F)cc3s2)CC1,benzene_ring
+120257,Please remove a amide from the molecule CCOc1ccc(-n2ncc(C(=O)N[C@H]3CCCCC[C@H]3C(=O)OC)c2C)nn1.,CCOc1ccc(-n2ncc(C(=O)N[C@H]3CCCCC[C@H]3C(=O)OC)c2C)nn1,amide
+99862,Modify the molecule C[C@H]1CC(NC(=O)CSc2nc([O-])c3cnn(-c4cccc(Cl)c4)c3n2)=NO1 by removing a halo.,C[C@H]1CC(NC(=O)CSc2nc([O-])c3cnn(-c4cccc(Cl)c4)c3n2)=NO1,halo
+166553,Please remove a amide from the molecule CCN1C(=O)COc2ccc(C(=O)Cn3nnc4ccccc43)cc21.,CCN1C(=O)COc2ccc(C(=O)Cn3nnc4ccccc43)cc21,amide
+162654,Modify the molecule O=C(CC[NH+]1CCN(c2ccccc2)CC1)NNC(=O)Nc1cccc(C(F)(F)F)c1 by removing a halo.,O=C(CC[NH+]1CCN(c2ccccc2)CC1)NNC(=O)Nc1cccc(C(F)(F)F)c1,halo
+56360,Remove a amide from the molecule CCCC(=CC(=O)Nc1nccs1)CCC.,CCCC(=CC(=O)Nc1nccs1)CCC,amide
+222333,Modify the molecule Cc1csc([C@H]2CCCCN2C(=O)[C@@H]2CCOc3ccccc32)n1 by removing a amide.,Cc1csc([C@H]2CCCCN2C(=O)[C@@H]2CCOc3ccccc32)n1,amide
+56758,Please remove a halo from the molecule C[NH+](Cc1ccc(Br)cc1)Cc1nnc(-c2cccs2)o1.,C[NH+](Cc1ccc(Br)cc1)Cc1nnc(-c2cccs2)o1,halo
+134573,Please remove a amide from the molecule O=C(c1ncccc1C(F)(F)F)N1CC[C@H](Oc2cccnc2)C1.,O=C(c1ncccc1C(F)(F)F)N1CC[C@H](Oc2cccnc2)C1,amide
+78814,Remove a benzene_ring from the molecule COc1cc(/C=N/NC(=O)c2cccc(F)c2)c(Br)c(Br)c1O.,COc1cc(/C=N/NC(=O)c2cccc(F)c2)c(Br)c(Br)c1O,benzene_ring
+74445,Modify the molecule CCC(CC)S(=O)(=O)/N=C(\[O-])[C@@H]1CCC[C@@H](C(F)(F)F)C1 by removing a halo.,CCC(CC)S(=O)(=O)/N=C(\[O-])[C@@H]1CCC[C@@H](C(F)(F)F)C1,halo
+23483,Modify the molecule Cc1ccc(/C=C2\SC(S)=NC2=O)c(C)c1 by removing a benzene_ring.,Cc1ccc(/C=C2\SC(S)=NC2=O)c(C)c1,benzene_ring
+48141,Remove a benzene_ring from the molecule Cc1ccccc1[C@@H](C)NC(=O)N1CCC(OCc2ccccc2F)CC1.,Cc1ccccc1[C@@H](C)NC(=O)N1CCC(OCc2ccccc2F)CC1,benzene_ring
+33920,Please remove a amide from the molecule C=C1c2ccccc2C(=O)N1CCC(=O)N1CCc2ccccc21.,C=C1c2ccccc2C(=O)N1CCC(=O)N1CCc2ccccc21,amide
+26892,Modify the molecule CC(C)CN1CCO[C@@H](CNC(=O)c2ccc[nH]c2=O)C1 by removing a amide.,CC(C)CN1CCO[C@@H](CNC(=O)c2ccc[nH]c2=O)C1,amide
+156757,Remove a amide from the molecule CC1(NC(=O)c2cc3cc(F)ccc3oc2=O)Cc2ccccc2C1.,CC1(NC(=O)c2cc3cc(F)ccc3oc2=O)Cc2ccccc2C1,amide
+132341,Modify the molecule CC(C)[NH+](CCC#N)[C@@H]1CCOC2(CCOCC2)C1 by removing a nitrile.,CC(C)[NH+](CCC#N)[C@@H]1CCOC2(CCOCC2)C1,nitrile
+157944,Please remove a halo from the molecule O=C(c1ccc(CSc2nc3ccncc3n2Cc2ccccc2F)cc1)N1CCCCC1.,O=C(c1ccc(CSc2nc3ccncc3n2Cc2ccccc2F)cc1)N1CCCCC1,halo
+8740,Remove a halo from the molecule Cc1nn(C)c(Cl)c1CS(=O)(=O)c1ccc([N+](=O)[O-])cc1.,Cc1nn(C)c(Cl)c1CS(=O)(=O)c1ccc([N+](=O)[O-])cc1,halo
+33019,Modify the molecule C[NH+]1CCC(C(=O)N[C@@H]2CCCc3nc(-c4cccnc4)ncc32)CC1 by removing a amide.,C[NH+]1CCC(C(=O)N[C@@H]2CCCc3nc(-c4cccnc4)ncc32)CC1,amide
+29719,Modify the molecule Cc1cc(-n2c(C)cc(/C=C/C(=O)N3CCC[C@@H]3c3ccccc3)c2C)no1 by removing a amide.,Cc1cc(-n2c(C)cc(/C=C/C(=O)N3CCC[C@@H]3c3ccccc3)c2C)no1,amide
+164587,Remove a hydroxyl from the molecule COc1ccc2[nH]c3c(c2c1)CCN1C(=O)N([C@@H](C)/C(O)=N/C[C@H]2CCCO2)C(=O)[C@@]31C.,COc1ccc2[nH]c3c(c2c1)CCN1C(=O)N([C@@H](C)/C(O)=N/C[C@H]2CCCO2)C(=O)[C@@]31C,hydroxyl
+162689,Please remove a amine from the molecule COc1ccc(Br)cc1CNc1cnccc1C#N.,COc1ccc(Br)cc1CNc1cnccc1C#N,amine
+147011,Remove a halo from the molecule O=S(=O)(c1cccc(C(F)(F)F)c1)N(Cc1ccsc1)Cc1ccccn1.,O=S(=O)(c1cccc(C(F)(F)F)c1)N(Cc1ccsc1)Cc1ccccn1,halo
+134445,Please remove a halo from the molecule Fc1ccc2c(c1)[C@@H]([NH2+]Cc1cccc(OCC(F)F)c1)CCO2.,Fc1ccc2c(c1)[C@@H]([NH2+]Cc1cccc(OCC(F)F)c1)CCO2,halo
+188512,Modify the molecule CC[C@@H](C)NC(=O)[C@H]1CSCN1C(=O)Cc1ccc2c(c1)CCO2 by removing a amide.,CC[C@@H](C)NC(=O)[C@H]1CSCN1C(=O)Cc1ccc2c(c1)CCO2,amide
+6751,Modify the molecule Cc1nc2ccc(N(C)C(=O)[C@@H](C)NC(=O)C(C)(C)C)cc2s1 by removing a amide.,Cc1nc2ccc(N(C)C(=O)[C@@H](C)NC(=O)C(C)(C)C)cc2s1,amide
+148356,Remove a benzene_ring from the molecule COc1ccc(OC)c(C(=O)C[C@@H]2c3c(cc4c(c3OC)OCO4)CC[NH+]2C)c1.,COc1ccc(OC)c(C(=O)C[C@@H]2c3c(cc4c(c3OC)OCO4)CC[NH+]2C)c1,benzene_ring
+35327,Modify the molecule Cc1ccc2c(CS/C(N)=[NH+]/C(C)(C)C)cc(=O)oc2c1 by removing a amine.,Cc1ccc2c(CS/C(N)=[NH+]/C(C)(C)C)cc(=O)oc2c1,amine
+19604,Please remove a amide from the molecule Cc1cc(CNC(=O)c2ccc(-c3ccccc3)cc2)c(C)o1.,Cc1cc(CNC(=O)c2ccc(-c3ccccc3)cc2)c(C)o1,amide
+72048,Modify the molecule CCn1nc(C)c(CNC(=O)Nc2ccc(OC(C)C)cc2C)c1C by removing a benzene_ring.,CCn1nc(C)c(CNC(=O)Nc2ccc(OC(C)C)cc2C)c1C,benzene_ring
+53044,Please remove a halo from the molecule CC(C)NC(=O)[C@@H](C)N1CCc2onc(-c3ccc(C(F)(F)F)cc3)c2C1.,CC(C)NC(=O)[C@@H](C)N1CCc2onc(-c3ccc(C(F)(F)F)cc3)c2C1,halo
+104304,Remove a benzene_ring from the molecule Cc1nn(CCCNC(=O)Nc2ccccc2C(F)(F)F)c(C)c1Br.,Cc1nn(CCCNC(=O)Nc2ccccc2C(F)(F)F)c(C)c1Br,benzene_ring
+61747,Modify the molecule COC(=O)NC(C)(C)C(=O)NCC[C@H](O)c1ccccc1 by removing a benzene_ring.,COC(=O)NC(C)(C)C(=O)NCC[C@H](O)c1ccccc1,benzene_ring
+149342,Please remove a amide from the molecule Cc1cccc(OC[C@@H](O)Cn2c([C@@H]3CC(=O)N(c4ccccc4C)C3)nc3ccccc32)c1.,Cc1cccc(OC[C@@H](O)Cn2c([C@@H]3CC(=O)N(c4ccccc4C)C3)nc3ccccc32)c1,amide
+206596,Remove a amide from the molecule O=C(Cn1c(Cc2ccccc2)nn(-c2ccc(Cl)cc2)c1=O)NC1CCC1.,O=C(Cn1c(Cc2ccccc2)nn(-c2ccc(Cl)cc2)c1=O)NC1CCC1,amide
+51886,Please remove a halo from the molecule O=C(Nc1cnc2ccccc2n1)c1cc2cc(F)ccc2oc1=O.,O=C(Nc1cnc2ccccc2n1)c1cc2cc(F)ccc2oc1=O,halo
+120080,Remove a nitro from the molecule O=C(Nc1ccccc1)Nc1ccc(NC(=O)c2cccc([N+](=O)[O-])c2)cc1.,O=C(Nc1ccccc1)Nc1ccc(NC(=O)c2cccc([N+](=O)[O-])c2)cc1,nitro
+186816,Modify the molecule Cc1ccc(/C([O-])=N/S(=O)(=O)c2ccc(C#N)cc2)cc1F by removing a halo.,Cc1ccc(/C([O-])=N/S(=O)(=O)c2ccc(C#N)cc2)cc1F,halo
+66330,Remove a benzene_ring from the molecule Cc1ccc(NC(=S)N/N=C/c2ccc(-c3ccc([N+](=O)[O-])cc3)o2)cc1F.,Cc1ccc(NC(=S)N/N=C/c2ccc(-c3ccc([N+](=O)[O-])cc3)o2)cc1F,benzene_ring
+166417,Remove a hydroxyl from the molecule COc1ccc(C[C@H](O)[C@@H]2CCCc3cccnc32)cc1.,COc1ccc(C[C@H](O)[C@@H]2CCCc3cccnc32)cc1,hydroxyl
+212405,Please remove a amine from the molecule COc1ccnc(N[C@@H]2CCc3cc(N)ccc32)n1.,COc1ccnc(N[C@@H]2CCc3cc(N)ccc32)n1,amine
+131279,Please remove a halo from the molecule Cc1nc(CN2CCN(c3ncc(Cl)cc3Cl)CC2)no1.,Cc1nc(CN2CCN(c3ncc(Cl)cc3Cl)CC2)no1,halo
+76590,Remove a benzene_ring from the molecule COc1cc(C)c(C(=O)N2CCc3c([nH]c4ccccc34)C2)cc1OC.,COc1cc(C)c(C(=O)N2CCc3c([nH]c4ccccc34)C2)cc1OC,benzene_ring
+227355,Please remove a nitro from the molecule Cc1cc(O)c(C[NH+]2C[C@@H](C)C[C@H](C)C2)c2c1C(=O)/C(=C\c1ccc([N+](=O)[O-])cc1)O2.,Cc1cc(O)c(C[NH+]2C[C@@H](C)C[C@H](C)C2)c2c1C(=O)/C(=C\c1ccc([N+](=O)[O-])cc1)O2,nitro
+224844,Modify the molecule COc1ccc(C(=O)Nc2cccc3[nH]cnc23)cc1[N+](=O)[O-] by removing a amide.,COc1ccc(C(=O)Nc2cccc3[nH]cnc23)cc1[N+](=O)[O-],amide
+99515,Remove a benzene_ring from the molecule CNc1ccc(/C=C/C(=O)c2ccc(SC)c(OC)c2)cc1[N+](=O)[O-].,CNc1ccc(/C=C/C(=O)c2ccc(SC)c(OC)c2)cc1[N+](=O)[O-],benzene_ring
+217048,Modify the molecule CC(C)N(C)S(=O)(=O)N1CCN(CC(=O)N2CCCC[C@H]2C)CC1 by removing a amide.,CC(C)N(C)S(=O)(=O)N1CCN(CC(=O)N2CCCC[C@H]2C)CC1,amide
+111443,Please remove a halo from the molecule C[C@@H]1C[C@H]1Nc1nc(Br)cn2ccnc12.,C[C@@H]1C[C@H]1Nc1nc(Br)cn2ccnc12,halo
+206859,Modify the molecule CCC[C@@H](C)C(=O)Nc1cccc(NC(=O)c2ccco2)c1C by removing a benzene_ring.,CCC[C@@H](C)C(=O)Nc1cccc(NC(=O)c2ccco2)c1C,benzene_ring
+51993,Modify the molecule O=C(c1ccn(COc2ccc(Br)cc2)n1)N1CCCCCC1 by removing a benzene_ring.,O=C(c1ccn(COc2ccc(Br)cc2)n1)N1CCCCCC1,benzene_ring
+123719,Please remove a nitro from the molecule COc1ccc(/C=N/NC(=O)COc2ccccc2C)cc1[N+](=O)[O-].,COc1ccc(/C=N/NC(=O)COc2ccccc2C)cc1[N+](=O)[O-],nitro
+247258,Please remove a amide from the molecule CC1CC[NH+](C[C@@H]2CCCN(C(=O)N[C@H](C)CC(=O)NC(C)C)C2)CC1.,CC1CC[NH+](C[C@@H]2CCCN(C(=O)N[C@H](C)CC(=O)NC(C)C)C2)CC1,amide
+177877,Remove a benzene_ring from the molecule COc1ccc(F)cc1CSCc1nc(CC(C)C)no1.,COc1ccc(F)cc1CSCc1nc(CC(C)C)no1,benzene_ring
+99225,Remove a halo from the molecule Cc1c([O-])nc(SCC(=O)Nc2nccs2)n(-c2ccc(F)cc2)c1=O.,Cc1c([O-])nc(SCC(=O)Nc2nccs2)n(-c2ccc(F)cc2)c1=O,halo
+136498,Remove a halo from the molecule N[C@]1(C(=O)[O-])CC[C@@H]([NH+]2CCC(C(F)(F)F)CC2)C1.,N[C@]1(C(=O)[O-])CC[C@@H]([NH+]2CCC(C(F)(F)F)CC2)C1,halo
+74675,Remove a amide from the molecule CC1(C)c2[nH]c3ccccc3c2C[C@@H]2C(=O)N(C3CCCC3)CC(=O)N21.,CC1(C)c2[nH]c3ccccc3c2C[C@@H]2C(=O)N(C3CCCC3)CC(=O)N21,amide
+185507,Please remove a benzene_ring from the molecule COc1ccccc1[C@@H](NC(=O)/C=C/c1cnn(C)c1C)c1ccccn1.,COc1ccccc1[C@@H](NC(=O)/C=C/c1cnn(C)c1C)c1ccccn1,benzene_ring
+96474,Remove a benzene_ring from the molecule O=C(/C=C/c1ccc2c(c1)OCO2)NNC(=O)c1nn(Cc2ccccc2)c(=O)c2ccccc12.,O=C(/C=C/c1ccc2c(c1)OCO2)NNC(=O)c1nn(Cc2ccccc2)c(=O)c2ccccc12,benzene_ring
+24339,Modify the molecule CS(=O)(=O)c1ccc(CC(=O)Nc2ccccc2C2[NH+]=c3ccccc3=[NH+]2)cc1 by removing a benzene_ring.,CS(=O)(=O)c1ccc(CC(=O)Nc2ccccc2C2[NH+]=c3ccccc3=[NH+]2)cc1,benzene_ring
+120026,Modify the molecule C=Cc1c(C)nn(-c2ccccc2)c1C by removing a benzene_ring.,C=Cc1c(C)nn(-c2ccccc2)c1C,benzene_ring
+127469,Please remove a halo from the molecule CCn1c2ccccc2c2cc(NC(=O)c3ccc(F)c(S(=O)(=O)N4CCOCC4)c3)ccc21.,CCn1c2ccccc2c2cc(NC(=O)c3ccc(F)c(S(=O)(=O)N4CCOCC4)c3)ccc21,halo
+168412,Remove a hydroxyl from the molecule O=C(c1ccccc1Cl)N1N=C(C(F)(F)F)C[C@@]1(O)C1CCCCC1.,O=C(c1ccccc1Cl)N1N=C(C(F)(F)F)C[C@@]1(O)C1CCCCC1,hydroxyl
+95587,Please remove a benzene_ring from the molecule Cc1ccccc1[C@H]1C[C@@H]1C(=O)N1CCC(n2cncn2)CC1.,Cc1ccccc1[C@H]1C[C@@H]1C(=O)N1CCC(n2cncn2)CC1,benzene_ring
+31082,Remove a benzene_ring from the molecule COCCN(Cc1ccccn1)C(=O)[C@H]1C[C@H]1c1ccccc1C.,COCCN(Cc1ccccn1)C(=O)[C@H]1C[C@H]1c1ccccc1C,benzene_ring
+16087,Modify the molecule CCc1cccc2c1=[NH+]CC=2/C=C(\C#N)c1nc2ccccc2[nH]1 by removing a amine.,CCc1cccc2c1=[NH+]CC=2/C=C(\C#N)c1nc2ccccc2[nH]1,amine
+220779,Modify the molecule CCOC(=O)c1c(C2CC2)csc1NC(=O)/C=C/c1ccc(C)o1 by removing a amide.,CCOC(=O)c1c(C2CC2)csc1NC(=O)/C=C/c1ccc(C)o1,amide
+88187,Please remove a halo from the molecule Cc1cc(NC(=O)c2ccc(/C=C3\SC(=O)N(c4cccc(C(F)(F)F)c4)C3=O)cc2)no1.,Cc1cc(NC(=O)c2ccc(/C=C3\SC(=O)N(c4cccc(C(F)(F)F)c4)C3=O)cc2)no1,halo
+175410,Please remove a benzene_ring from the molecule O=[N+]([O-])c1cccc2c1N[C@H](c1cccc(Cl)c1)[C@@H]1CC=C[C@@H]21.,O=[N+]([O-])c1cccc2c1N[C@H](c1cccc(Cl)c1)[C@@H]1CC=C[C@@H]21,benzene_ring
+201619,Modify the molecule Cc1ccsc1CNC(=O)CSc1ncn[nH]1 by removing a amide.,Cc1ccsc1CNC(=O)CSc1ncn[nH]1,amide
+94561,Please remove a amide from the molecule O=C1C[C@@H](C(=O)NC[C@H]2CCCN(c3ncccn3)C2)c2ccc(F)cc2N1.,O=C1C[C@@H](C(=O)NC[C@H]2CCCN(c3ncccn3)C2)c2ccc(F)cc2N1,amide
+234008,Modify the molecule COC(=O)c1ncn2c1C(=O)N(c1ccc(C)c(F)c1)[C@](C)(C(=O)NCc1ccccc1OC)C2 by removing a benzene_ring.,COC(=O)c1ncn2c1C(=O)N(c1ccc(C)c(F)c1)[C@](C)(C(=O)NCc1ccccc1OC)C2,benzene_ring
+87327,Remove a nitro from the molecule C[C@@H]1CN(C(=O)Cn2cc([N+](=O)[O-])cn2)C[C@@H](C)O1.,C[C@@H]1CN(C(=O)Cn2cc([N+](=O)[O-])cn2)C[C@@H](C)O1,nitro
+150068,Modify the molecule COc1ccc([C@@H]2C[C@@H](C)N(c3cccc[nH+]3)C2)cc1 by removing a benzene_ring.,COc1ccc([C@@H]2C[C@@H](C)N(c3cccc[nH+]3)C2)cc1,benzene_ring
+145987,Remove a benzene_ring from the molecule CCC[C@H](C)NC(=O)[C@H](C)Nc1c(C)nn(-c2ccccc2)c1C.,CCC[C@H](C)NC(=O)[C@H](C)Nc1c(C)nn(-c2ccccc2)c1C,benzene_ring
+30138,Modify the molecule O=C(CSc1ncnc2sc3c(c12)CCCC3)NC[C@@H]1CCCO1 by removing a amide.,O=C(CSc1ncnc2sc3c(c12)CCCC3)NC[C@@H]1CCCO1,amide
+22525,Please remove a amide from the molecule C[C@@H]1COC[C@@H](C)N1C(=O)CSc1nnnn1C.,C[C@@H]1COC[C@@H](C)N1C(=O)CSc1nnnn1C,amide
+81971,Please remove a halo from the molecule C[C@H](NC(=O)c1ccccc1I)c1ccc(Br)cc1.,C[C@H](NC(=O)c1ccccc1I)c1ccc(Br)cc1,halo
+178196,Please remove a thiol from the molecule SCC1(CSc2nncs2)CC1.,SCC1(CSc2nncs2)CC1,thiol
+181321,Modify the molecule O=C([O-])[C@H]1CCN(c2ccc(F)cc2)[C@@H]1c1ccc(C(F)(F)F)cc1 by removing a benzene_ring.,O=C([O-])[C@H]1CCN(c2ccc(F)cc2)[C@@H]1c1ccc(C(F)(F)F)cc1,benzene_ring
+157199,Modify the molecule CSc1ccc(NC(=O)N(C)[C@H](C)c2nc(C)sc2C)cc1 by removing a benzene_ring.,CSc1ccc(NC(=O)N(C)[C@H](C)c2nc(C)sc2C)cc1,benzene_ring
+206848,Remove a benzene_ring from the molecule COc1ccc(NC(=O)[C@H](C)Sc2cccc(F)c2)cc1OC.,COc1ccc(NC(=O)[C@H](C)Sc2cccc(F)c2)cc1OC,benzene_ring
+43377,Remove a hydroxyl from the molecule CCCC1CCC(C[NH3+])([C@@H](O)c2cccs2)CC1.,CCCC1CCC(C[NH3+])([C@@H](O)c2cccs2)CC1,hydroxyl
+4449,Modify the molecule Cc1nn(C)c2nc(NC[C@H](c3ccncc3)N3CCOCC3)sc12 by removing a amine.,Cc1nn(C)c2nc(NC[C@H](c3ccncc3)N3CCOCC3)sc12,amine
+241759,Remove a benzene_ring from the molecule O=S(=O)(NCCCn1ccnc1-c1ccccc1)c1cccs1.,O=S(=O)(NCCCn1ccnc1-c1ccccc1)c1cccs1,benzene_ring
+198348,Please remove a benzene_ring from the molecule Cc1c(C(=O)Nc2cccc(COCC3CC3)c2)cnn1-c1ccncc1.,Cc1c(C(=O)Nc2cccc(COCC3CC3)c2)cnn1-c1ccncc1,benzene_ring
+222008,Remove a benzene_ring from the molecule COc1cccc(C(=O)N/N=C\c2ccc(Sc3cccc4cccnc34)o2)c1.,COc1cccc(C(=O)N/N=C\c2ccc(Sc3cccc4cccnc34)o2)c1,benzene_ring
+231015,Modify the molecule C[C@@H]1CC[NH+](Cc2ccc([N+](=O)[O-])c(O)c2)C[C@@H]1C by removing a nitro.,C[C@@H]1CC[NH+](Cc2ccc([N+](=O)[O-])c(O)c2)C[C@@H]1C,nitro
+240544,Please remove a amide from the molecule O=C(Nc1ccc(Br)cc1)c1cccnc1NCc1ccccc1.,O=C(Nc1ccc(Br)cc1)c1cccnc1NCc1ccccc1,amide
+41223,Please remove a nitro from the molecule COc1cc(/C(C#N)=C/c2cccc3c2OCCCO3)ccc1[N+](=O)[O-].,COc1cc(/C(C#N)=C/c2cccc3c2OCCCO3)ccc1[N+](=O)[O-],nitro
+191245,Please remove a benzene_ring from the molecule CC(C)Cc1noc(C[NH2+][C@H](C)c2ccc(Cl)cc2Cl)n1.,CC(C)Cc1noc(C[NH2+][C@H](C)c2ccc(Cl)cc2Cl)n1,benzene_ring
+201795,Please remove a benzene_ring from the molecule Cc1ccccc1C(=O)Nc1cccc(C(=O)N2CCC[C@@H]2C(=O)NCCc2ccccc2)c1.,Cc1ccccc1C(=O)Nc1cccc(C(=O)N2CCC[C@@H]2C(=O)NCCc2ccccc2)c1,benzene_ring
+195391,Remove a halo from the molecule CC(C)c1cc(C(=O)NCCNC(=O)c2ccc(Cl)cc2)n(C)n1.,CC(C)c1cc(C(=O)NCCNC(=O)c2ccc(Cl)cc2)n(C)n1,halo
+138102,Modify the molecule COc1ccc([C@H]2CC(O)=Nc3c2c(=O)[nH]n3C(C)C)c(OC)c1OC by removing a hydroxyl.,COc1ccc([C@H]2CC(O)=Nc3c2c(=O)[nH]n3C(C)C)c(OC)c1OC,hydroxyl
+72891,Remove a amide from the molecule C[C@@H](Sc1ncc2ccccn12)C(=O)N(Cc1ccccc1)Cc1ccccc1.,C[C@@H](Sc1ncc2ccccn12)C(=O)N(Cc1ccccc1)Cc1ccccc1,amide
+217739,Please remove a benzene_ring from the molecule CC[C@@](C)([NH3+])C(=O)NC[C@H](c1ccccc1)[NH+]1CCCC1.,CC[C@@](C)([NH3+])C(=O)NC[C@H](c1ccccc1)[NH+]1CCCC1,benzene_ring
+18702,Remove a benzene_ring from the molecule CCOc1ccc(N2C(=O)C[C@H](SCC(=O)Nc3cccc(Cl)c3C)C2=O)cc1.,CCOc1ccc(N2C(=O)C[C@H](SCC(=O)Nc3cccc(Cl)c3C)C2=O)cc1,benzene_ring
+9587,Remove a amide from the molecule CCS(=O)(=O)C[C@@H](C)NC(=O)c1ccc(OC(F)F)cc1.,CCS(=O)(=O)C[C@@H](C)NC(=O)c1ccc(OC(F)F)cc1,amide
+50578,Modify the molecule C[C@@H](OC(=O)c1ccc(CC#N)cc1)c1nc2ccc(Cl)cc2n1C by removing a halo.,C[C@@H](OC(=O)c1ccc(CC#N)cc1)c1nc2ccc(Cl)cc2n1C,halo
+54671,Please remove a amide from the molecule CC1=C(C(=O)Nc2cc(C)ccn2)[C@H](c2cc([N+](=O)[O-])ccc2Cl)C2=C(CC(C)(C)CC2=O)N1.,CC1=C(C(=O)Nc2cc(C)ccn2)[C@H](c2cc([N+](=O)[O-])ccc2Cl)C2=C(CC(C)(C)CC2=O)N1,amide
+238362,Remove a amide from the molecule CCN[C@]1(C(N)=O)CC[C@H]([NH+]2CCC(C)(C)C2)C1.,CCN[C@]1(C(N)=O)CC[C@H]([NH+]2CCC(C)(C)C2)C1,amide
+24962,Remove a hydroxyl from the molecule CC(C)(C)C[C@H](CO)NC(=O)c1cccnc1Br.,CC(C)(C)C[C@H](CO)NC(=O)c1cccnc1Br,hydroxyl
+178092,Remove a amide from the molecule CC[NH+]1CC[C@H](N(C)C(=O)c2cccc(-n3cccn3)c2)[C@H](C)C1.,CC[NH+]1CC[C@H](N(C)C(=O)c2cccc(-n3cccn3)c2)[C@H](C)C1,amide
+176787,Remove a benzene_ring from the molecule Cc1ccc(O)c(C(=O)Nc2cccc(I)c2)c1.,Cc1ccc(O)c(C(=O)Nc2cccc(I)c2)c1,benzene_ring
+163983,Modify the molecule COc1ccc(C(=O)CSc2nc3ccccc3nc2-c2ccccc2)cc1OC by removing a benzene_ring.,COc1ccc(C(=O)CSc2nc3ccccc3nc2-c2ccccc2)cc1OC,benzene_ring
+155145,Please remove a amide from the molecule C[C@H](C(N)=O)N1CC[NH+](Cc2ccc3c(c2)CC(C)(C)O3)CC1.,C[C@H](C(N)=O)N1CC[NH+](Cc2ccc3c(c2)CC(C)(C)O3)CC1,amide
+205206,Please remove a amide from the molecule Cc1nc2cc(NC(=O)C(=O)NCC3(C)CCC3)ccc2o1.,Cc1nc2cc(NC(=O)C(=O)NCC3(C)CCC3)ccc2o1,amide
+22896,Remove a benzene_ring from the molecule CC(C)(C)OC(=O)N1CCC(COc2ccc(OC(F)(F)F)cc2)CC1.,CC(C)(C)OC(=O)N1CCC(COc2ccc(OC(F)(F)F)cc2)CC1,benzene_ring
+225345,Remove a benzene_ring from the molecule COc1cccc(CN(C(C)=O)c2c(C)nc3ccccn23)c1OC.,COc1cccc(CN(C(C)=O)c2c(C)nc3ccccn23)c1OC,benzene_ring
+172373,Remove a halo from the molecule [NH3+][C@@H](Cc1ccc(F)c(F)c1)c1ccc(F)cc1Br.,[NH3+][C@@H](Cc1ccc(F)c(F)c1)c1ccc(F)cc1Br,halo
+16047,Please remove a halo from the molecule O=C(COc1ccccc1-c1noc(-c2ccc(Cl)cc2)n1)N1CCCC1.,O=C(COc1ccccc1-c1noc(-c2ccc(Cl)cc2)n1)N1CCCC1,halo
+53496,Remove a amide from the molecule O=C(Nc1ccc(Br)cc1C(=O)[O-])c1ccc(Br)s1.,O=C(Nc1ccc(Br)cc1C(=O)[O-])c1ccc(Br)s1,amide
+88389,Please remove a nitro from the molecule COc1ccc(COc2ccc(CO)cc2)cc1[N+](=O)[O-].,COc1ccc(COc2ccc(CO)cc2)cc1[N+](=O)[O-],nitro
+4743,Please remove a amide from the molecule CCCn1c(C)cc(-c2csc(NC(=O)c3scnc3C)n2)c1C.,CCCn1c(C)cc(-c2csc(NC(=O)c3scnc3C)n2)c1C,amide
+5096,Please remove a benzene_ring from the molecule O=C(Nc1cccc2cnccc12)N(Cc1ccccc1F)C1CC1.,O=C(Nc1cccc2cnccc12)N(Cc1ccccc1F)C1CC1,benzene_ring
+223862,Remove a benzene_ring from the molecule Cc1ccccc1[C@@H]1CC(=O)C2=C(C1)Nc1ncnn1[C@@H]2c1ccc(F)cc1.,Cc1ccccc1[C@@H]1CC(=O)C2=C(C1)Nc1ncnn1[C@@H]2c1ccc(F)cc1,benzene_ring
+10616,Modify the molecule FC(F)(F)c1cnn(-c2nc(Br)cs2)c1 by removing a halo.,FC(F)(F)c1cnn(-c2nc(Br)cs2)c1,halo
+53668,Please remove a amide from the molecule Cc1c([C@@H]2c3ccccc3C(=O)N2CC(=O)Nc2cccnc2)c2ccccc2n1C.,Cc1c([C@@H]2c3ccccc3C(=O)N2CC(=O)Nc2cccnc2)c2ccccc2n1C,amide
+41909,Please remove a benzene_ring from the molecule O=C(CSc1cc(-c2ccccc2)ncn1)N1CCCC1.,O=C(CSc1cc(-c2ccccc2)ncn1)N1CCCC1,benzene_ring
+57020,Modify the molecule C[C@@H](NC(=O)[C@@H]1CCCO1)c1cccs1 by removing a amide.,C[C@@H](NC(=O)[C@@H]1CCCO1)c1cccs1,amide
+91042,Modify the molecule C[C@H](CNC(=O)c1cccc2[nH]ccc12)[NH+]1CCCC1 by removing a amide.,C[C@H](CNC(=O)c1cccc2[nH]ccc12)[NH+]1CCCC1,amide
+240691,Modify the molecule C[C@@H](c1ccccc1)N(C)C(=O)C[NH+]1CCCC[C@@H]1C(=O)N1CCOCC1 by removing a amide.,C[C@@H](c1ccccc1)N(C)C(=O)C[NH+]1CCCC[C@@H]1C(=O)N1CCOCC1,amide
+85564,Please remove a halo from the molecule CN(CC(=O)OCC(=O)c1ccc(Cl)s1)c1ncccn1.,CN(CC(=O)OCC(=O)c1ccc(Cl)s1)c1ncccn1,halo
+215683,Remove a amide from the molecule Cc1cc([N-]S(=O)(=O)c2ccc3c(c2)CN(C(=O)C(C)(C)C)CC3)no1.,Cc1cc([N-]S(=O)(=O)c2ccc3c(c2)CN(C(=O)C(C)(C)C)CC3)no1,amide
+81232,Remove a benzene_ring from the molecule Cc1ncccc1NC(=O)/C=C(/c1ccccc1)C(F)(F)F.,Cc1ncccc1NC(=O)/C=C(/c1ccccc1)C(F)(F)F,benzene_ring
+181265,Please remove a benzene_ring from the molecule Cc1ccc([S@@](=O)/N=C/c2ccc(F)cc2)cc1.,Cc1ccc([S@@](=O)/N=C/c2ccc(F)cc2)cc1,benzene_ring
+37108,Modify the molecule O=C(NCc1cccnc1OCC(F)(F)F)c1ccc2[nH]cnc2c1 by removing a amide.,O=C(NCc1cccnc1OCC(F)(F)F)c1ccc2[nH]cnc2c1,amide
+162717,Please remove a benzene_ring from the molecule CCc1ccc(Oc2nc3ccccn3c(=O)c2/C=C2/SC(=S)N(C[C@@H]3CCCO3)C2=O)cc1.,CCc1ccc(Oc2nc3ccccn3c(=O)c2/C=C2/SC(=S)N(C[C@@H]3CCCO3)C2=O)cc1,benzene_ring
+234858,Remove a benzene_ring from the molecule CC(C)(C)n1cc(NC(=O)N[C@H]2C[C@H]2c2ccccc2)cn1.,CC(C)(C)n1cc(NC(=O)N[C@H]2C[C@H]2c2ccccc2)cn1,benzene_ring
+239725,Remove a halo from the molecule NC(=O)c1ccc(NCc2cccc(Br)c2)nn1.,NC(=O)c1ccc(NCc2cccc(Br)c2)nn1,halo
+137377,Modify the molecule CC(=O)Nc1ccc(S(=O)(=O)N2CCC(Oc3nc4c(C)cccc4s3)CC2)cc1 by removing a amide.,CC(=O)Nc1ccc(S(=O)(=O)N2CCC(Oc3nc4c(C)cccc4s3)CC2)cc1,amide
+45404,Remove a benzene_ring from the molecule CC[C@H](C)c1ccc([C@@H](O)c2cscc2C)cc1.,CC[C@H](C)c1ccc([C@@H](O)c2cscc2C)cc1,benzene_ring
+20985,Please remove a amide from the molecule COc1nccnc1N1CCC[C@@H](N2CCCC2=O)C1.,COc1nccnc1N1CCC[C@@H](N2CCCC2=O)C1,amide
+12028,Modify the molecule Cc1cc(-n2cncn2)ccc1C(=O)Nc1c(C)cccc1Cl by removing a benzene_ring.,Cc1cc(-n2cncn2)ccc1C(=O)Nc1c(C)cccc1Cl,benzene_ring
+94487,Please remove a benzene_ring from the molecule Cc1c(Cl)cccc1-n1ccnc1S[C@@H](C)C(=O)NC(C)(C)C.,Cc1c(Cl)cccc1-n1ccnc1S[C@@H](C)C(=O)NC(C)(C)C,benzene_ring
+113918,Remove a benzene_ring from the molecule Cc1csc(N(C(=O)/C=C/c2ccccc2)c2ccccc2)n1.,Cc1csc(N(C(=O)/C=C/c2ccccc2)c2ccccc2)n1,benzene_ring
+248221,Please remove a amide from the molecule CCOC(=O)C1CCN(C(=O)COC(=O)c2n[nH]c3ccccc23)CC1.,CCOC(=O)C1CCN(C(=O)COC(=O)c2n[nH]c3ccccc23)CC1,amide
+125324,Please remove a amide from the molecule COc1ccc(C)c2sc(N(CC[NH+](C)C)C(=O)c3snnc3C)nc12.,COc1ccc(C)c2sc(N(CC[NH+](C)C)C(=O)c3snnc3C)nc12,amide
+175387,Modify the molecule Cc1cc(C)c(C)c(S(=O)(=O)Nc2ccc3c(c2)CN(C(=O)c2cccs2)CC3)c1C by removing a benzene_ring.,Cc1cc(C)c(C)c(S(=O)(=O)Nc2ccc3c(c2)CN(C(=O)c2cccs2)CC3)c1C,benzene_ring
+4492,Modify the molecule COC(=O)c1ccc(F)c(NC(=O)c2cccnc2SC)c1 by removing a halo.,COC(=O)c1ccc(F)c(NC(=O)c2cccnc2SC)c1,halo
+176475,Modify the molecule COCCN1C(=O)C(C#N)=C(C)/C(=C/c2ccc(OC)cc2OC)C1=O by removing a benzene_ring.,COCCN1C(=O)C(C#N)=C(C)/C(=C/c2ccc(OC)cc2OC)C1=O,benzene_ring
+59050,Please remove a benzene_ring from the molecule CC(=O)N[C@@H]1CCCN(C(=O)c2cccc(N[C@@H](C)C(C)C)c2C)C1.,CC(=O)N[C@@H]1CCCN(C(=O)c2cccc(N[C@@H](C)C(C)C)c2C)C1,benzene_ring
+92660,Please remove a halo from the molecule Cc1c(C(=O)N(C)c2ccccc2Cl)oc2c1/C(=N/O)CC(C)(C)C2.,Cc1c(C(=O)N(C)c2ccccc2Cl)oc2c1/C(=N/O)CC(C)(C)C2,halo
+179331,Modify the molecule COc1cccc([C@@H]2CN(C(=O)CSc3nc(C)n[nH]3)C[C@H]2C(=O)[O-])c1 by removing a amide.,COc1cccc([C@@H]2CN(C(=O)CSc3nc(C)n[nH]3)C[C@H]2C(=O)[O-])c1,amide
+141136,Modify the molecule O=C(Nc1ccc(NC(=O)[C@@H](O)c2ccccc2)cc1)C1CC1 by removing a benzene_ring.,O=C(Nc1ccc(NC(=O)[C@@H](O)c2ccccc2)cc1)C1CC1,benzene_ring
+235427,Please remove a halo from the molecule O=C(C1=C([O-])C(=O)N(Cc2cccnc2)[C@H]1c1ccc(Cl)cc1)c1cccs1.,O=C(C1=C([O-])C(=O)N(Cc2cccnc2)[C@H]1c1ccc(Cl)cc1)c1cccs1,halo
+168113,Modify the molecule CCOCC[NH+](C)[C@H](C)C(=O)N1CCC(C(N)=O)CC1 by removing a amide.,CCOCC[NH+](C)[C@H](C)C(=O)N1CCC(C(N)=O)CC1,amide
+25719,Modify the molecule C[C@@H](NC(=O)[C@@H](O)c1ccccc1)c1cccc(N2CCOC2=O)c1 by removing a benzene_ring.,C[C@@H](NC(=O)[C@@H](O)c1ccccc1)c1cccc(N2CCOC2=O)c1,benzene_ring
+22846,Please remove a benzene_ring from the molecule CCCc1nccn1-c1cccc([C@@H](C)[NH2+]CC)c1.,CCCc1nccn1-c1cccc([C@@H](C)[NH2+]CC)c1,benzene_ring
+242163,Remove a halo from the molecule CCCC(=O)Nc1nnc(CC(=O)N/N=C/c2ccccc2Cl)s1.,CCCC(=O)Nc1nnc(CC(=O)N/N=C/c2ccccc2Cl)s1,halo
+162140,Modify the molecule COc1ccc(/C=N/N=C2\NC(=O)[C@@H](Cc3cccc(Cl)c3)S2)cc1 by removing a benzene_ring.,COc1ccc(/C=N/N=C2\NC(=O)[C@@H](Cc3cccc(Cl)c3)S2)cc1,benzene_ring
+160016,Please remove a amide from the molecule C[C@@H](C(=O)NCCC1=CCCCC1)N1CCn2c(nnc2C2CC2)C1.,C[C@@H](C(=O)NCCC1=CCCCC1)N1CCn2c(nnc2C2CC2)C1,amide
+114019,Modify the molecule CCOc1ccc(S(=O)(=O)N[C@@H]2CC[C@H]([NH+](C)C)C2)cc1Br by removing a amine.,CCOc1ccc(S(=O)(=O)N[C@@H]2CC[C@H]([NH+](C)C)C2)cc1Br,amine
+184085,Please remove a nitrile from the molecule CCCCN(C)C(=O)C1CC[NH+](Cc2cn3ccccc3c2C#N)CC1.,CCCCN(C)C(=O)C1CC[NH+](Cc2cn3ccccc3c2C#N)CC1,nitrile
+232933,Please remove a amide from the molecule Cn1c(=O)[nH]c2cc(C(=O)N[C@@H]3c4ccccc4C[C@@H]3O)ccc21.,Cn1c(=O)[nH]c2cc(C(=O)N[C@@H]3c4ccccc4C[C@@H]3O)ccc21,amide
+223588,Remove a amide from the molecule C[C@H]1C[C@@H](c2ccc(F)cc2)C[NH+]1CC(=O)NNC(=O)C1CCC1.,C[C@H]1C[C@@H](c2ccc(F)cc2)C[NH+]1CC(=O)NNC(=O)C1CCC1,amide
+41585,Remove a hydroxyl from the molecule CC(C)(O)CSCCNC(=O)N1CC[C@@H]2CCCC[C@@H]21.,CC(C)(O)CSCCNC(=O)N1CC[C@@H]2CCCC[C@@H]21,hydroxyl
+141738,Please remove a halo from the molecule CCNC(=O)c1ccc(Cl)cc1NC(=O)[C@@H]1C[C@@H]1C.,CCNC(=O)c1ccc(Cl)cc1NC(=O)[C@@H]1C[C@@H]1C,halo
+16029,Remove a halo from the molecule O=C(Cc1ccc(Cl)cc1)N1CCN(CC(F)(F)F)CC1.,O=C(Cc1ccc(Cl)cc1)N1CCN(CC(F)(F)F)CC1,halo
+29711,Please remove a amine from the molecule COC(=O)[C@@H](N)C12CC3CC(CC(C3)C1)C2.,COC(=O)[C@@H](N)C12CC3CC(CC(C3)C1)C2,amine
+47198,Remove a amide from the molecule Nc1ccc(Oc2ccc3c(c2)C(=O)N(Cc2cccnc2)C3=O)cc1.,Nc1ccc(Oc2ccc3c(c2)C(=O)N(Cc2cccnc2)C3=O)cc1,amide
+188749,Please remove a amine from the molecule O=C([O-])CSC(=S)Nc1ccccn1.,O=C([O-])CSC(=S)Nc1ccccn1,amine
+47787,Modify the molecule CC(=O)c1cccc(NC(=O)[C@@H](C)n2c(=O)cc(C)c3cc(C)cc(C)c32)c1 by removing a amide.,CC(=O)c1cccc(NC(=O)[C@@H](C)n2c(=O)cc(C)c3cc(C)cc(C)c32)c1,amide
+9008,Please remove a amide from the molecule C[C@H]1CN(CC(=O)N(CCC(N)=O)c2ccc(F)cc2)C(C)(C)CO1.,C[C@H]1CN(CC(=O)N(CCC(N)=O)c2ccc(F)cc2)C(C)(C)CO1,amide
+5876,Remove a benzene_ring from the molecule COc1ccc(N2CCN([C@H]3CCC[NH+](Cc4[nH]c5ccccc5c4C)C3)CC2)cc1.,COc1ccc(N2CCN([C@H]3CCC[NH+](Cc4[nH]c5ccccc5c4C)C3)CC2)cc1,benzene_ring
+107964,Please remove a amide from the molecule CN(C)C(=S)SCC(=O)N1c2ccccc2NC(=O)C1(C)C.,CN(C)C(=S)SCC(=O)N1c2ccccc2NC(=O)C1(C)C,amide
+221656,Modify the molecule Cc1ncn(-c2cc(N3CCN(C(=O)Cc4ccccc4)CC3)ncn2)c1C by removing a amide.,Cc1ncn(-c2cc(N3CCN(C(=O)Cc4ccccc4)CC3)ncn2)c1C,amide
+48533,Remove a benzene_ring from the molecule Cc1cccc(Nc2nc3nccc(-c4cccs4)c3c(=O)[nH]2)c1.,Cc1cccc(Nc2nc3nccc(-c4cccs4)c3c(=O)[nH]2)c1,benzene_ring
+179993,Remove a hydroxyl from the molecule COC(=O)C(C)(C)Cn1ccc([C@H](C)O)c1.,COC(=O)C(C)(C)Cn1ccc([C@H](C)O)c1,hydroxyl
+237163,Modify the molecule CCOc1ccc(N2C(=O)[C@@H](C)S/C2=C(\C#N)C(=O)N[C@H](C)c2ccccc2)cc1 by removing a benzene_ring.,CCOc1ccc(N2C(=O)[C@@H](C)S/C2=C(\C#N)C(=O)N[C@H](C)c2ccccc2)cc1,benzene_ring
+240650,Please remove a benzene_ring from the molecule COc1cc(C[NH+]2CC[C@@H](NC(=O)c3ccn(C(C)C)n3)C2)cc(OC)c1.,COc1cc(C[NH+]2CC[C@@H](NC(=O)c3ccn(C(C)C)n3)C2)cc(OC)c1,benzene_ring
+66118,Remove a nitro from the molecule Cn1ccc(Nc2ccncc2[N+](=O)[O-])n1.,Cn1ccc(Nc2ccncc2[N+](=O)[O-])n1,nitro
+247386,Modify the molecule CCCCCC(C)(C)CNc1ncnc2[nH]cnc12 by removing a amine.,CCCCCC(C)(C)CNc1ncnc2[nH]cnc12,amine
+103041,Modify the molecule CO[C@H]1CCC[C@@H]1OC(=O)CCCNC(C)=O by removing a amide.,CO[C@H]1CCC[C@@H]1OC(=O)CCCNC(C)=O,amide
+216337,Please remove a halo from the molecule CCCn1c(=O)c2ccc(Cl)cc2n2c(SCC(=O)Nc3cccc(C)c3)nnc12.,CCCn1c(=O)c2ccc(Cl)cc2n2c(SCC(=O)Nc3cccc(C)c3)nnc12,halo
+190013,Modify the molecule Cc1ccccc1NC(=O)NNC(=O)c1cccc(NC(=O)C2CCCCC2)c1 by removing a amide.,Cc1ccccc1NC(=O)NNC(=O)c1cccc(NC(=O)C2CCCCC2)c1,amide
+227896,Please remove a amide from the molecule NC(=O)[C@@H](NC[C@@H]1CCCO1)c1ccc(Br)cc1F.,NC(=O)[C@@H](NC[C@@H]1CCCO1)c1ccc(Br)cc1F,amide
+228110,Remove a benzene_ring from the molecule O=C(Nc1ccc(S(=O)(=O)N[C@@H](c2ccccc2)C2CC2)cc1)C(F)(F)F.,O=C(Nc1ccc(S(=O)(=O)N[C@@H](c2ccccc2)C2CC2)cc1)C(F)(F)F,benzene_ring
+93586,Modify the molecule C[C@@H](O)c1cccn1Cc1cc(Br)ccc1F by removing a halo.,C[C@@H](O)c1cccn1Cc1cc(Br)ccc1F,halo
+24565,Please remove a benzene_ring from the molecule N#Cc1ccc(NC(=O)N2CCN(C(=O)CCC3CCCCC3)CC2)cc1.,N#Cc1ccc(NC(=O)N2CCN(C(=O)CCC3CCCCC3)CC2)cc1,benzene_ring
+200450,Modify the molecule O=C(Cc1ccc([N+](=O)[O-])cc1)N=c1[nH]c2ccccc2[nH]1 by removing a nitro.,O=C(Cc1ccc([N+](=O)[O-])cc1)N=c1[nH]c2ccccc2[nH]1,nitro
+86482,Remove a benzene_ring from the molecule COc1ccccc1C[C@H]1CCCN1C(=O)c1cnc([C@H]2CCCO2)s1.,COc1ccccc1C[C@H]1CCCN1C(=O)c1cnc([C@H]2CCCO2)s1,benzene_ring
+22420,Please remove a benzene_ring from the molecule C[C@H]1CC[C@H](C[NH3+])CN1[C@@H](C)c1cc(F)cc(F)c1.,C[C@H]1CC[C@H](C[NH3+])CN1[C@@H](C)c1cc(F)cc(F)c1,benzene_ring
+137334,Remove a halo from the molecule C[C@H]1C[C@H]1c1ccc(CN(C(=O)c2c[nH]c(=O)c(Cl)c2)C2CC2)o1.,C[C@H]1C[C@H]1c1ccc(CN(C(=O)c2c[nH]c(=O)c(Cl)c2)C2CC2)o1,halo
+35182,Please remove a amide from the molecule COC[C@H](C)NC(=O)C(=O)Nc1cccc(-c2nc(C3CC3)n[nH]2)c1.,COC[C@H](C)NC(=O)C(=O)Nc1cccc(-c2nc(C3CC3)n[nH]2)c1,amide
+198905,Modify the molecule C[C@@H]1CCN(C(=O)c2cc(=O)[nH]c3cc(F)ccc23)C[C@H]1O by removing a halo.,C[C@@H]1CCN(C(=O)c2cc(=O)[nH]c3cc(F)ccc23)C[C@H]1O,halo
+130851,Remove a halo from the molecule Cc1ccc(Cn2nc(C)c(C(=O)N3CCN(CCOc4ccccc4)CC3)c2Cl)cc1.,Cc1ccc(Cn2nc(C)c(C(=O)N3CCN(CCOc4ccccc4)CC3)c2Cl)cc1,halo
+90042,Modify the molecule COc1ccc2c(C)c(CCC(=O)N[C@@H]3C[C@@H]3C)c(=O)oc2c1 by removing a amide.,COc1ccc2c(C)c(CCC(=O)N[C@@H]3C[C@@H]3C)c(=O)oc2c1,amide
+45541,Please remove a amide from the molecule O=C(COC(=O)c1ccc(S(=O)(=O)N2CCCC2)cc1)Nc1ccc(F)cc1Cl.,O=C(COC(=O)c1ccc(S(=O)(=O)N2CCCC2)cc1)Nc1ccc(F)cc1Cl,amide
+82299,Please remove a amide from the molecule Cc1ccc(-n2nc(C)cc2NC(=O)C(=O)N(C)CC(=O)NC(C)C)cc1.,Cc1ccc(-n2nc(C)cc2NC(=O)C(=O)N(C)CC(=O)NC(C)C)cc1,amide
+235201,Remove a amide from the molecule CC(C)(C)CC(=O)Nc1ccccc1Oc1ccccc1.,CC(C)(C)CC(=O)Nc1ccccc1Oc1ccccc1,amide
+242827,Remove a amide from the molecule O=C([C@H]1CCC[NH+]1[C@H]1CCC[C@@H](C2CC2)C1)N1CCOCC1.,O=C([C@H]1CCC[NH+]1[C@H]1CCC[C@@H](C2CC2)C1)N1CCOCC1,amide
+120558,Please remove a halo from the molecule CC(=O)Nc1ccc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)cc1.,CC(=O)Nc1ccc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)cc1,halo
+181869,Please remove a halo from the molecule O=C(CS(=O)(=O)Cc1noc(-c2ccccc2Cl)n1)NCC1CCC1.,O=C(CS(=O)(=O)Cc1noc(-c2ccccc2Cl)n1)NCC1CCC1,halo
+185864,Remove a amide from the molecule COC(=O)c1cccc(NC(=O)/C(=C/c2ccco2)c2ccccc2)c1.,COC(=O)c1cccc(NC(=O)/C(=C/c2ccco2)c2ccccc2)c1,amide
+206801,Remove a amide from the molecule CCN(CC)C(=O)c1ccc([N+](=O)[O-])c(C)c1.,CCN(CC)C(=O)c1ccc([N+](=O)[O-])c(C)c1,amide
+194608,Modify the molecule Cc1csc(CNC(=O)[C@@H]2CSCN2C(=O)OC(C)(C)C)n1 by removing a amide.,Cc1csc(CNC(=O)[C@@H]2CSCN2C(=O)OC(C)(C)C)n1,amide
+92787,Modify the molecule C[NH2+][C@H](CCO)c1cccnc1Cl by removing a halo.,C[NH2+][C@H](CCO)c1cccnc1Cl,halo
+149027,Remove a hydroxyl from the molecule C#CCC[C@@H](O)[C@]1([NH+](C)C)CCC[C@H](C)C1.,C#CCC[C@@H](O)[C@]1([NH+](C)C)CCC[C@H](C)C1,hydroxyl
+197619,Remove a benzene_ring from the molecule CC1CCN(C(=O)[C@@H](C)Sc2nnnn2Cc2ccccc2)CC1.,CC1CCN(C(=O)[C@@H](C)Sc2nnnn2Cc2ccccc2)CC1,benzene_ring
+31084,Remove a nitro from the molecule Cc1ccoc1C(=O)OCc1ccc([N+](=O)[O-])cc1.,Cc1ccoc1C(=O)OCc1ccc([N+](=O)[O-])cc1,nitro
+168644,Remove a benzene_ring from the molecule OC1(C(F)(F)F)CC[NH+](Cc2ncc(-c3cccc(Cl)c3)o2)CC1.,OC1(C(F)(F)F)CC[NH+](Cc2ncc(-c3cccc(Cl)c3)o2)CC1,benzene_ring
+222627,Please remove a halo from the molecule CN(Cc1ccc(Cl)nc1)C(=O)NCc1ccc(-n2cncn2)cc1.,CN(Cc1ccc(Cl)nc1)C(=O)NCc1ccc(-n2cncn2)cc1,halo
+170677,Modify the molecule COc1ccccc1-n1c(SCc2c(C)noc2C)nc2ccsc2c1=O by removing a benzene_ring.,COc1ccccc1-n1c(SCc2c(C)noc2C)nc2ccsc2c1=O,benzene_ring
+182393,Modify the molecule C[C@@H](Cc1ccsc1)N(C)C(=O)c1ccc(CNS(C)(=O)=O)o1 by removing a amine.,C[C@@H](Cc1ccsc1)N(C)C(=O)c1ccc(CNS(C)(=O)=O)o1,amine
+168698,Modify the molecule Cc1cccc(N2C[C@H](c3nc4ccccc4n3C[C@@H](O)COc3ccc(Cl)cc3)CC2=O)c1 by removing a benzene_ring.,Cc1cccc(N2C[C@H](c3nc4ccccc4n3C[C@@H](O)COc3ccc(Cl)cc3)CC2=O)c1,benzene_ring
+209142,Please remove a halo from the molecule CC[C@@H](C)NC(=O)N1CC[C@H](Oc2ccc(C(F)(F)F)cn2)C1.,CC[C@@H](C)NC(=O)N1CC[C@H](Oc2ccc(C(F)(F)F)cn2)C1,halo
+3807,Remove a amide from the molecule Cn1ccnc1SCC(=O)N1CCC(C(=O)N2CCCCCC2)CC1.,Cn1ccnc1SCC(=O)N1CCC(C(=O)N2CCCCCC2)CC1,amide
+106584,Please remove a halo from the molecule CC(=O)N(CCc1ccccc1)CC(=O)Nc1ccc(C(N)=O)cc1F.,CC(=O)N(CCc1ccccc1)CC(=O)Nc1ccc(C(N)=O)cc1F,halo
+94524,Modify the molecule CN(C)C(=O)c1ccc(F)c(NC(=O)c2ccnc(Cl)c2)c1 by removing a benzene_ring.,CN(C)C(=O)c1ccc(F)c(NC(=O)c2ccnc(Cl)c2)c1,benzene_ring
+101365,Remove a amide from the molecule Cc1c[nH]c(CN(C)C(=O)[C@@]23CNC[C@@H]2C[NH2+]C3)[nH+]1.,Cc1c[nH]c(CN(C)C(=O)[C@@]23CNC[C@@H]2C[NH2+]C3)[nH+]1,amide
+32789,Remove a benzene_ring from the molecule COc1ccccc1[C@@H]1c2cccn2CCN1C(=O)CN(C(=O)c1ccco1)C(C)C.,COc1ccccc1[C@@H]1c2cccn2CCN1C(=O)CN(C(=O)c1ccco1)C(C)C,benzene_ring
+18956,Remove a amine from the molecule CCCOc1ccc(-c2nc(N)ccc2[N+](=O)[O-])cc1.,CCCOc1ccc(-c2nc(N)ccc2[N+](=O)[O-])cc1,amine
+176285,Remove a benzene_ring from the molecule COc1c(Br)cccc1CNC(=O)N(C)[C@H](C)C1CC1.,COc1c(Br)cccc1CNC(=O)N(C)[C@H](C)C1CC1,benzene_ring
+201625,Modify the molecule CCc1nnc(NC(=O)c2ccccc2NC(=O)[C@H]2CC(=O)N(c3ccc(Cl)cc3)C2)s1 by removing a benzene_ring.,CCc1nnc(NC(=O)c2ccccc2NC(=O)[C@H]2CC(=O)N(c3ccc(Cl)cc3)C2)s1,benzene_ring
+233705,Modify the molecule Cc1ccc(C(=O)NNC(=O)CCc2c[nH]c3c(C)cccc23)o1 by removing a amide.,Cc1ccc(C(=O)NNC(=O)CCc2c[nH]c3c(C)cccc23)o1,amide
+179507,Remove a halo from the molecule CN(C)c1nc(N)nc(CN2CC[C@H](c3cccc(F)c3)C2)n1.,CN(C)c1nc(N)nc(CN2CC[C@H](c3cccc(F)c3)C2)n1,halo
+19884,Modify the molecule Cc1cc(CNC(=O)CCC[NH+]2CCN(c3ccccc3)CC2)on1 by removing a amide.,Cc1cc(CNC(=O)CCC[NH+]2CCN(c3ccccc3)CC2)on1,amide
+36647,Please remove a benzene_ring from the molecule CS(=O)(=O)c1ccc(Nc2ccccc2)c(N)c1.,CS(=O)(=O)c1ccc(Nc2ccccc2)c(N)c1,benzene_ring
+24068,Modify the molecule CC[NH2+][C@@H](c1ccccc1OCC)[C@@H](C)c1ccccn1 by removing a benzene_ring.,CC[NH2+][C@@H](c1ccccc1OCC)[C@@H](C)c1ccccn1,benzene_ring
+225306,Modify the molecule Cc1[nH]c2ccccc2c1CC(=O)OCC(=O)N(C(C)C)C(C)C by removing a amide.,Cc1[nH]c2ccccc2c1CC(=O)OCC(=O)N(C(C)C)C(C)C,amide
+114451,Modify the molecule COc1ccc(Cc2nc3ccccc3n2CC(=O)N2CCCC[C@@H]2C)cc1OC by removing a benzene_ring.,COc1ccc(Cc2nc3ccccc3n2CC(=O)N2CCCC[C@@H]2C)cc1OC,benzene_ring
+207567,Modify the molecule Clc1ccc(C[NH+]2CCCCC2)c(Cl)c1 by removing a halo.,Clc1ccc(C[NH+]2CCCCC2)c(Cl)c1,halo
+70730,Remove a halo from the molecule CC(C)[C@H]([NH3+])c1noc(Cc2ccc(F)c(F)c2)n1.,CC(C)[C@H]([NH3+])c1noc(Cc2ccc(F)c(F)c2)n1,halo
+85999,Please remove a amine from the molecule Nc1ccc2nc(-c3cccc(-c4nc5ccc(N)cc5s4)n3)sc2c1.,Nc1ccc2nc(-c3cccc(-c4nc5ccc(N)cc5s4)n3)sc2c1,amine
+9874,Please remove a halo from the molecule COc1cccc(CN(C)Cc2ncnn2C)c1OC(F)F.,COc1cccc(CN(C)Cc2ncnn2C)c1OC(F)F,halo
+138032,Modify the molecule Cc1cc(N)nn1Cc1ccc(F)cc1Cl by removing a benzene_ring.,Cc1cc(N)nn1Cc1ccc(F)cc1Cl,benzene_ring
+199376,Modify the molecule Cc1nc(C)n(C[C@@H]2CCC[NH+]2Cc2cnn(-c3ccccc3)n2)n1 by removing a benzene_ring.,Cc1nc(C)n(C[C@@H]2CCC[NH+]2Cc2cnn(-c3ccccc3)n2)n1,benzene_ring
+214620,Please remove a benzene_ring from the molecule Cc1ccc(-c2nc3ccccc3c3nnc(S[C@H](C)C(=O)NC[C@@H]4CCCO4)n23)cc1.,Cc1ccc(-c2nc3ccccc3c3nnc(S[C@H](C)C(=O)NC[C@@H]4CCCO4)n23)cc1,benzene_ring
+94637,Modify the molecule CN(C)S(=O)(=O)c1cc(C(=O)NCc2csc(=O)[nH]2)co1 by removing a amide.,CN(C)S(=O)(=O)c1cc(C(=O)NCc2csc(=O)[nH]2)co1,amide
+54449,Remove a benzene_ring from the molecule C[S@](=O)c1ccc(CNC(=O)CCc2c(F)cccc2F)cc1.,C[S@](=O)c1ccc(CNC(=O)CCc2c(F)cccc2F)cc1,benzene_ring
+959,Modify the molecule c1ccc(Cn2c(SCc3ncon3)nnc2-c2cccs2)cc1 by removing a benzene_ring.,c1ccc(Cn2c(SCc3ncon3)nnc2-c2cccs2)cc1,benzene_ring
+113513,Please remove a benzene_ring from the molecule CCc1c(C[NH2+]CC(C)C)cnn1-c1ccccc1Br.,CCc1c(C[NH2+]CC(C)C)cnn1-c1ccccc1Br,benzene_ring
+135573,Remove a amide from the molecule COc1cccc(N2CCN(C(=O)c3cccc(OC)c3O)CC2)c1.,COc1cccc(N2CCN(C(=O)c3cccc(OC)c3O)CC2)c1,amide
+73681,Modify the molecule CNc1ncnc(-c2cc(Br)ccc2F)c1[N+](=O)[O-] by removing a benzene_ring.,CNc1ncnc(-c2cc(Br)ccc2F)c1[N+](=O)[O-],benzene_ring
+17113,Remove a amide from the molecule Cc1nsc(NC(=O)[C@@H]2C=C[C@@H]([NH3+])C2)c1C(=O)[O-].,Cc1nsc(NC(=O)[C@@H]2C=C[C@@H]([NH3+])C2)c1C(=O)[O-],amide
+87312,Modify the molecule C[C@@H]1CCc2nc(C[NH+](C)CC(=O)Nc3ccccc3)sc2C1 by removing a benzene_ring.,C[C@@H]1CCc2nc(C[NH+](C)CC(=O)Nc3ccccc3)sc2C1,benzene_ring
+111949,Modify the molecule C[NH+]1CCC[C@@H](C(=O)NCC(=O)Nc2cccc(F)c2)C1 by removing a amide.,C[NH+]1CCC[C@@H](C(=O)NCC(=O)Nc2cccc(F)c2)C1,amide
+180668,Remove a amide from the molecule Cc1ccc(F)cc1NC(=O)[C@@H](C)O/N=C/C(=O)Nc1ccc(F)cc1.,Cc1ccc(F)cc1NC(=O)[C@@H](C)O/N=C/C(=O)Nc1ccc(F)cc1,amide
+76161,Modify the molecule Cc1ccc(C(=O)C2CC[NH+](Cc3ccc(-n4cncn4)c(C)c3)CC2)cc1 by removing a benzene_ring.,Cc1ccc(C(=O)C2CC[NH+](Cc3ccc(-n4cncn4)c(C)c3)CC2)cc1,benzene_ring
+131561,Please remove a benzene_ring from the molecule Cn1ccnc1SCC(=O)NCc1coc(-c2ccccc2)n1.,Cn1ccnc1SCC(=O)NCc1coc(-c2ccccc2)n1,benzene_ring
+53723,Please remove a benzene_ring from the molecule CC[C@@H](C)C(=O)Nc1c(C)cc(C)cc1Cl.,CC[C@@H](C)C(=O)Nc1c(C)cc(C)cc1Cl,benzene_ring
+172485,Modify the molecule C#CCN(CC(=O)[O-])[C@H](C)c1ccccc1[N+](=O)[O-] by removing a nitro.,C#CCN(CC(=O)[O-])[C@H](C)c1ccccc1[N+](=O)[O-],nitro
+180418,Remove a amide from the molecule CC(C)[C@H](C(=O)Oc1cccc(-n2cccn2)c1)N1CCCC1=O.,CC(C)[C@H](C(=O)Oc1cccc(-n2cccn2)c1)N1CCCC1=O,amide
+183295,Modify the molecule COc1ccc(Br)cc1/C=N/N1C(=S)[NH+]=N[C@@H]1c1ccccc1 by removing a halo.,COc1ccc(Br)cc1/C=N/N1C(=S)[NH+]=N[C@@H]1c1ccccc1,halo
+53736,Remove a nitro from the molecule O=C(Nc1cccc2c1CCCC2)c1ccc([N+](=O)[O-])s1.,O=C(Nc1cccc2c1CCCC2)c1ccc([N+](=O)[O-])s1,nitro
+236718,Modify the molecule COc1ccc(N2CCN(C(=O)CN3C(=O)[C@@H]4CC=CC[C@H]4C3=O)CC2)cc1 by removing a amide.,COc1ccc(N2CCN(C(=O)CN3C(=O)[C@@H]4CC=CC[C@H]4C3=O)CC2)cc1,amide
+39753,Remove a amide from the molecule CSc1cc2c(cc1NC(=O)c1cccc(F)c1Cl)OCCO2.,CSc1cc2c(cc1NC(=O)c1cccc(F)c1Cl)OCCO2,amide
+171727,Modify the molecule C[C@@H](CC(=O)N1CC[NH2+]CC1)CC(C)(C)C by removing a amide.,C[C@@H](CC(=O)N1CC[NH2+]CC1)CC(C)(C)C,amide
+164249,Modify the molecule Cc1ccc(NC(=O)[C@H]2Oc3ccccc3[C@H]2NC(=O)C2=NN=C(c3cc(Cl)ccc3O)C2)cc1 by removing a hydroxyl.,Cc1ccc(NC(=O)[C@H]2Oc3ccccc3[C@H]2NC(=O)C2=NN=C(c3cc(Cl)ccc3O)C2)cc1,hydroxyl
+174961,Modify the molecule CC(C)[C@H](NC(=O)c1ccccc1F)C(=O)N1CCOC[C@H]1C by removing a benzene_ring.,CC(C)[C@H](NC(=O)c1ccccc1F)C(=O)N1CCOC[C@H]1C,benzene_ring
+109015,Modify the molecule CCC(=O)Nc1ccc(S(=O)(=O)N(C(=O)CC)c2ccccc2)cc1 by removing a amide.,CCC(=O)Nc1ccc(S(=O)(=O)N(C(=O)CC)c2ccccc2)cc1,amide
+57102,Please remove a amide from the molecule C[C@H]1C[C@H]([NH3+])CN(CC(=O)N2CCC[C@H]3CCCC[C@@H]32)C1.,C[C@H]1C[C@H]([NH3+])CN(CC(=O)N2CCC[C@H]3CCCC[C@@H]32)C1,amide
+100085,Modify the molecule O=C(NC[C@@H]1CCCO1)c1ccc2c(c1)[C@H]1C=CC[C@H]1[C@@H](c1ccc3ccccc3c1)N2 by removing a amine.,O=C(NC[C@@H]1CCCO1)c1ccc2c(c1)[C@H]1C=CC[C@H]1[C@@H](c1ccc3ccccc3c1)N2,amine
+3858,Please remove a amide from the molecule C[C@H](CC1CCCC1)C(=O)Nc1ccc(C(=O)NC2CCOCC2)cc1.,C[C@H](CC1CCCC1)C(=O)Nc1ccc(C(=O)NC2CCOCC2)cc1,amide
+164209,Remove a benzene_ring from the molecule CCC(C)(C)NC(=O)/C=C/c1ccc(S(=O)(=O)N2CCCCCC2)cc1.,CCC(C)(C)NC(=O)/C=C/c1ccc(S(=O)(=O)N2CCCCCC2)cc1,benzene_ring
+226050,Modify the molecule Cn1c(=O)ccn(CC(=O)NC2(c3ccc(F)cc3F)CCCC2)c1=O by removing a halo.,Cn1c(=O)ccn(CC(=O)NC2(c3ccc(F)cc3F)CCCC2)c1=O,halo
+45772,Please remove a benzene_ring from the molecule CCc1ncc(CN(C)C(=O)c2c[nH]nc2-c2ccc(OC)cc2)s1.,CCc1ncc(CN(C)C(=O)c2c[nH]nc2-c2ccc(OC)cc2)s1,benzene_ring
+132003,Remove a halo from the molecule COc1ccc(Cl)cc1NC(=O)CC[C@@H]1CCC[NH+](C2CCOCC2)C1.,COc1ccc(Cl)cc1NC(=O)CC[C@@H]1CCC[NH+](C2CCOCC2)C1,halo
+204733,Please remove a benzene_ring from the molecule COc1ccc(CC2(CO)CCN(c3ccc4ccccc4[nH+]3)CC2)cc1.,COc1ccc(CC2(CO)CCN(c3ccc4ccccc4[nH+]3)CC2)cc1,benzene_ring
+26467,Please remove a benzene_ring from the molecule Cc1cc(-c2nnc(CN3CCC[C@H]3Cc3cccc(F)c3)o2)c(C)o1.,Cc1cc(-c2nnc(CN3CCC[C@H]3Cc3cccc(F)c3)o2)c(C)o1,benzene_ring
+153486,Modify the molecule CCc1ccc(NC(=O)C(=O)N(C)Cc2cccs2)cc1[N+](=O)[O-] by removing a benzene_ring.,CCc1ccc(NC(=O)C(=O)N(C)Cc2cccs2)cc1[N+](=O)[O-],benzene_ring
+124689,Modify the molecule CN1CCc2nc[nH]c2C12CC[NH+](Cc1cnn(-c3ccccc3F)c1)CC2 by removing a benzene_ring.,CN1CCc2nc[nH]c2C12CC[NH+](Cc1cnn(-c3ccccc3F)c1)CC2,benzene_ring
+169868,Modify the molecule CC(C)c1nn(-c2ccccc2Cl)c(N)c1I by removing a amine.,CC(C)c1nn(-c2ccccc2Cl)c(N)c1I,amine
+83390,Please remove a benzene_ring from the molecule CCc1ccc(C[NH+]2CCN(C(=O)Cc3ccccc3F)CC2)o1.,CCc1ccc(C[NH+]2CCN(C(=O)Cc3ccccc3F)CC2)o1,benzene_ring
+84311,Remove a benzene_ring from the molecule CCOC(=O)c1c(NC(=O)c2ccc(SC)cc2)sc2c1CC[NH+](CC)C2.,CCOC(=O)c1c(NC(=O)c2ccc(SC)cc2)sc2c1CC[NH+](CC)C2,benzene_ring
+186206,Modify the molecule CC(=O)c1ccc(NC(=O)[C@@H]2CC(=O)N=C(N3CC[NH+](Cc4ccc5c(c4)OCO5)CC3)N2)cc1 by removing a amide.,CC(=O)c1ccc(NC(=O)[C@@H]2CC(=O)N=C(N3CC[NH+](Cc4ccc5c(c4)OCO5)CC3)N2)cc1,amide
+44978,Modify the molecule COc1cccc2c1OC[C@@H](C(=O)N1CCC[C@H](c3ccn[nH]3)C1)C2 by removing a amide.,COc1cccc2c1OC[C@@H](C(=O)N1CCC[C@H](c3ccn[nH]3)C1)C2,amide
+187776,Remove a benzene_ring from the molecule O=C(NCc1ccc(-n2cccn2)cc1)N1CCC[C@H]1c1ccc2c(c1)OCCO2.,O=C(NCc1ccc(-n2cccn2)cc1)N1CCC[C@H]1c1ccc2c(c1)OCCO2,benzene_ring
+178449,Remove a benzene_ring from the molecule CO[C@H]1C[NH2+][C@H](C(=O)NCCc2ccc(F)cc2C)C1.,CO[C@H]1C[NH2+][C@H](C(=O)NCCc2ccc(F)cc2C)C1,benzene_ring
+243795,Please remove a amide from the molecule O=C(Nn1cnc2ccccc2c1=O)c1cccc(S(=O)(=O)N2CCCCC2)c1.,O=C(Nn1cnc2ccccc2c1=O)c1cccc(S(=O)(=O)N2CCCCC2)c1,amide
+92926,Modify the molecule Cc1nc(-c2ccccc2Cl)nc2sc(C(=O)[O-])c(N)c12 by removing a benzene_ring.,Cc1nc(-c2ccccc2Cl)nc2sc(C(=O)[O-])c(N)c12,benzene_ring
+4010,Please remove a amide from the molecule NC(=O)CONC(=O)[C@H]1CCCc2sccc21.,NC(=O)CONC(=O)[C@H]1CCCc2sccc21,amide
+460,Modify the molecule Cc1cc(NN)c2cccc(OC(F)(F)F)c2[nH+]1 by removing a halo.,Cc1cc(NN)c2cccc(OC(F)(F)F)c2[nH+]1,halo
+194062,Please remove a amide from the molecule CC[C@H](NC(=O)C1=Cc2cc(Cl)ccc2OC1)c1c(C)nn(C)c1C.,CC[C@H](NC(=O)C1=Cc2cc(Cl)ccc2OC1)c1c(C)nn(C)c1C,amide
+167710,Remove a amine from the molecule COc1ccccc1NS(=O)(=O)c1ccc(Cc2cc(C)n[nH]c2=O)cc1.,COc1ccccc1NS(=O)(=O)c1ccc(Cc2cc(C)n[nH]c2=O)cc1,amine
+149824,Modify the molecule Cn1ccc2cc(S(=O)(=O)N3CCC[C@H](C(=O)N4CCC5(CC4)OCCO5)C3)ccc21 by removing a amide.,Cn1ccc2cc(S(=O)(=O)N3CCC[C@H](C(=O)N4CCC5(CC4)OCCO5)C3)ccc21,amide
+239006,Remove a amide from the molecule O=C(NCc1cccs1)c1ccc([C@H]2Nc3ccccc3S(=O)(=O)N2)cc1.,O=C(NCc1cccs1)c1ccc([C@H]2Nc3ccccc3S(=O)(=O)N2)cc1,amide
+226478,Remove a amine from the molecule CNc1ccc(C[NH+]2C[C@H](C)[C@@H](C)C2)cn1.,CNc1ccc(C[NH+]2C[C@H](C)[C@@H](C)C2)cn1,amine
+125154,Modify the molecule CC(C)N(CC(F)F)C(=O)C1C[C@H](C)O[C@H](C)C1 by removing a halo.,CC(C)N(CC(F)F)C(=O)C1C[C@H](C)O[C@H](C)C1,halo
+128523,Remove a amide from the molecule COC[C@H](NC(=O)Cc1coc2cc(C)c(C)cc12)C(N)=O.,COC[C@H](NC(=O)Cc1coc2cc(C)c(C)cc12)C(N)=O,amide
+149126,Please remove a halo from the molecule Cc1nn(C)c(Cl)c1CSc1nnnn1C(C)C.,Cc1nn(C)c(Cl)c1CSc1nnnn1C(C)C,halo
+168731,Remove a benzene_ring from the molecule NC(=O)c1cccc(CNC(=O)[C@H]2C[C@H]2c2ccc(F)cc2)c1.,NC(=O)c1cccc(CNC(=O)[C@H]2C[C@H]2c2ccc(F)cc2)c1,benzene_ring
+166885,Please remove a amide from the molecule NC(=O)c1cc(-c2cs/c(=N\C[C@@H]3CCCO3)n2/N=C/c2ccccn2)ccc1O.,NC(=O)c1cc(-c2cs/c(=N\C[C@@H]3CCCO3)n2/N=C/c2ccccn2)ccc1O,amide
+218331,Please remove a amide from the molecule Cc1ccc(-n2nc(N3CCC[C@H](C(=O)Nc4ccc(F)cc4F)C3)ccc2=O)cc1Cl.,Cc1ccc(-n2nc(N3CCC[C@H](C(=O)Nc4ccc(F)cc4F)C3)ccc2=O)cc1Cl,amide
+133352,Remove a halo from the molecule CSCCOC(=O)[C@@H](C)Oc1cccc(Cl)c1.,CSCCOC(=O)[C@@H](C)Oc1cccc(Cl)c1,halo
+127165,Modify the molecule CN(CCCS(C)(=O)=O)C(=O)[C@H]1CCCC[NH+]1Cc1cccnc1 by removing a amide.,CN(CCCS(C)(=O)=O)C(=O)[C@H]1CCCC[NH+]1Cc1cccnc1,amide
+136936,Please remove a benzene_ring from the molecule CSc1ccc([C@H](C)[NH2+][C@H](C[C@@H]2CCOC2)c2ccccc2)cc1.,CSc1ccc([C@H](C)[NH2+][C@H](C[C@@H]2CCOC2)c2ccccc2)cc1,benzene_ring
+42293,Please remove a halo from the molecule C[C@H]1Sc2nnc(-c3ccncc3)n2N=C1c1ccc(F)c(F)c1.,C[C@H]1Sc2nnc(-c3ccncc3)n2N=C1c1ccc(F)c(F)c1,halo
+188535,Remove a benzene_ring from the molecule CN(c1ccc(-c2nc(Cc3ccc(F)cc3)no2)c[nH+]1)C1CCOCC1.,CN(c1ccc(-c2nc(Cc3ccc(F)cc3)no2)c[nH+]1)C1CCOCC1,benzene_ring
+112944,Please remove a amide from the molecule C[C@@H]1C[C@@H](N(C)C(=O)c2cc(CCc3ccccc3)ccc2O)CC[NH+]1C.,C[C@@H]1C[C@@H](N(C)C(=O)c2cc(CCc3ccccc3)ccc2O)CC[NH+]1C,amide
+123033,Please remove a amide from the molecule O=C(CCn1ccc2ccccc21)Nc1ccc2c(c1)CCC(=O)N2.,O=C(CCn1ccc2ccccc21)Nc1ccc2c(c1)CCC(=O)N2,amide
+168939,Please remove a benzene_ring from the molecule CCOC(=O)C1=C(C)Nc2ncnn2[C@@H]1c1cc(Cl)c(OC)c(OC)c1.,CCOC(=O)C1=C(C)Nc2ncnn2[C@@H]1c1cc(Cl)c(OC)c(OC)c1,benzene_ring
+60736,Modify the molecule CCc1ccc(NC(=O)[C@H](C)Nc2ccc3c(c2)CCN3C(C)=O)cc1 by removing a amine.,CCc1ccc(NC(=O)[C@H](C)Nc2ccc3c(c2)CCN3C(C)=O)cc1,amine
+59367,Remove a benzene_ring from the molecule COCc1ccc(C(=O)NCCC2CCN(c3cc[nH+]cc3)CC2)cc1.,COCc1ccc(C(=O)NCCC2CCN(c3cc[nH+]cc3)CC2)cc1,benzene_ring
+57585,Please remove a hydroxyl from the molecule CC(C)=CC(=O)C[C@@](O)(c1ccccc1)C(F)(F)F.,CC(C)=CC(=O)C[C@@](O)(c1ccccc1)C(F)(F)F,hydroxyl
+45916,Modify the molecule COC(=O)CNC(=O)CCc1c[nH]c2ccc(C)cc12 by removing a amide.,COC(=O)CNC(=O)CCc1c[nH]c2ccc(C)cc12,amide
+42810,Remove a amide from the molecule O=C1NC(=O)[C@@H](CC(=O)N2CCOCC2)N1.,O=C1NC(=O)[C@@H](CC(=O)N2CCOCC2)N1,amide
+89813,Modify the molecule COCCN(Cc1ccco1)C(=O)Nc1ccc(Cl)c([N+](=O)[O-])c1 by removing a nitro.,COCCN(Cc1ccco1)C(=O)Nc1ccc(Cl)c([N+](=O)[O-])c1,nitro
+202209,Remove a benzene_ring from the molecule Cc1ccc(S(=O)(=O)N2CCNC(=O)CC2)cc1[N+](=O)[O-].,Cc1ccc(S(=O)(=O)N2CCNC(=O)CC2)cc1[N+](=O)[O-],benzene_ring
+56915,Modify the molecule CC(=O)c1cccc(NC(=O)c2cc(C)nc3c2c(C)nn3-c2ccc(F)cc2)c1 by removing a amide.,CC(=O)c1cccc(NC(=O)c2cc(C)nc3c2c(C)nn3-c2ccc(F)cc2)c1,amide
+109356,Modify the molecule Cc1nc2cc(NC(=O)[C@H]3CCCN(c4ccc(-n5ccnc5)nn4)C3)ccc2s1 by removing a amide.,Cc1nc2cc(NC(=O)[C@H]3CCCN(c4ccc(-n5ccnc5)nn4)C3)ccc2s1,amide
+139750,Modify the molecule Cc1ccc(Cl)cc1N1CCN([C@@H](c2ccccc2F)c2nnnn2Cc2ccco2)CC1 by removing a benzene_ring.,Cc1ccc(Cl)cc1N1CCN([C@@H](c2ccccc2F)c2nnnn2Cc2ccco2)CC1,benzene_ring
+25598,Modify the molecule Cc1cccc(C(=O)Nc2ccc3c(c2)OCCCO3)c1C by removing a amide.,Cc1cccc(C(=O)Nc2ccc3c(c2)OCCCO3)c1C,amide
+117474,Modify the molecule CCc1ccccc1NC(=O)CN(C)C(=O)[C@@H]1CC(=O)N(c2ccccc2CC)C1 by removing a amide.,CCc1ccccc1NC(=O)CN(C)C(=O)[C@@H]1CC(=O)N(c2ccccc2CC)C1,amide
+2493,Please remove a amide from the molecule CC[NH+](CCNC(=O)N[C@H]1CC(=O)N(C(C)(C)C)C1)C(C)C.,CC[NH+](CCNC(=O)N[C@H]1CC(=O)N(C(C)(C)C)C1)C(C)C,amide
+205310,Remove a amide from the molecule C[C@H]1OCC[C@H]1C(=O)Nc1ccc2nc(-c3cccs3)[nH]c2c1.,C[C@H]1OCC[C@H]1C(=O)Nc1ccc2nc(-c3cccs3)[nH]c2c1,amide
+177148,Modify the molecule CC[C@@H](C)[C@](C)(O)[C@@H]1CCC[NH2+]C1 by removing a hydroxyl.,CC[C@@H](C)[C@](C)(O)[C@@H]1CCC[NH2+]C1,hydroxyl
+117860,Please remove a benzene_ring from the molecule O=C([O-])CCc1nc(-c2ccccc2)c(-c2ccccc2)o1.,O=C([O-])CCc1nc(-c2ccccc2)c(-c2ccccc2)o1,benzene_ring
+238912,Remove a halo from the molecule Cc1ccc(NC(=O)N(C)CCOc2ccccc2F)cc1-n1cnnn1.,Cc1ccc(NC(=O)N(C)CCOc2ccccc2F)cc1-n1cnnn1,halo
+65251,Please remove a hydroxyl from the molecule C[C@@H](CCO)SCC(=O)c1cc(F)ccc1O.,C[C@@H](CCO)SCC(=O)c1cc(F)ccc1O,hydroxyl
+129199,Please remove a benzene_ring from the molecule CC[NH2+][C@@H](CC[C@@H]1Cc2ccccc2S1)c1ccccc1.,CC[NH2+][C@@H](CC[C@@H]1Cc2ccccc2S1)c1ccccc1,benzene_ring
+199246,Modify the molecule CNC(=O)[C@@H]1CN(C(=O)[C@H]2CC(=O)N(c3ccc4c(c3)OCCO4)C2)c2ccccc2O1 by removing a amide.,CNC(=O)[C@@H]1CN(C(=O)[C@H]2CC(=O)N(c3ccc4c(c3)OCCO4)C2)c2ccccc2O1,amide
+219408,Remove a amide from the molecule COc1c(F)cc(NC(=O)C(=O)N2CC[C@H](OCCC(C)C)C2)cc1F.,COc1c(F)cc(NC(=O)C(=O)N2CC[C@H](OCCC(C)C)C2)cc1F,amide
+237259,Please remove a amide from the molecule CC(C)c1cc(=O)[nH]c(-n2nc(-c3cccs3)cc2NC(=O)Cc2ccc(Cl)cc2)n1.,CC(C)c1cc(=O)[nH]c(-n2nc(-c3cccs3)cc2NC(=O)Cc2ccc(Cl)cc2)n1,amide
+13468,Please remove a halo from the molecule O=C1OC(/C=C\c2ccccc2)=N/C1=C\c1cccc(Cl)c1.,O=C1OC(/C=C\c2ccccc2)=N/C1=C\c1cccc(Cl)c1,halo
+132502,Modify the molecule CCC[C@@H]1CN(Cc2ccc(N3CCOCC3)c(F)c2)CC[NH2+]1 by removing a benzene_ring.,CCC[C@@H]1CN(Cc2ccc(N3CCOCC3)c(F)c2)CC[NH2+]1,benzene_ring
+13492,Modify the molecule CCC(CC)CNc1nccn(CC(C)C)c1=O by removing a amine.,CCC(CC)CNc1nccn(CC(C)C)c1=O,amine
+190762,Remove a hydroxyl from the molecule C[C@@H](Cc1ccc(O)cc1)NC(=O)Nc1cc(C#N)ccc1OC(F)F.,C[C@@H](Cc1ccc(O)cc1)NC(=O)Nc1cc(C#N)ccc1OC(F)F,hydroxyl
+70993,Remove a hydroxyl from the molecule Cc1cc(C)cc(OC[C@H](O)C[NH+]2CCC[C@@H]2c2cc(C)no2)c1.,Cc1cc(C)cc(OC[C@H](O)C[NH+]2CCC[C@@H]2c2cc(C)no2)c1,hydroxyl
+174284,Please remove a benzene_ring from the molecule COC(=O)[C@H]1CCC[C@H]1NC(=O)Nc1ccc(F)c(C)c1.,COC(=O)[C@H]1CCC[C@H]1NC(=O)Nc1ccc(F)c(C)c1,benzene_ring
+208985,Modify the molecule CCOc1c(F)cccc1C(=O)NCCC(=O)N1CCCCCC1 by removing a benzene_ring.,CCOc1c(F)cccc1C(=O)NCCC(=O)N1CCCCCC1,benzene_ring
+29307,Remove a amide from the molecule Cc1ccc(S(=O)(=O)N2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)c3ccco3)CC2)cc1C.,Cc1ccc(S(=O)(=O)N2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)c3ccco3)CC2)cc1C,amide
+41691,Please remove a hydroxyl from the molecule Cc1cccc(NC(=O)c2sc3c(c2C)[C@H](c2cccc(O)c2)CC(O)=N3)c1.,Cc1cccc(NC(=O)c2sc3c(c2C)[C@H](c2cccc(O)c2)CC(O)=N3)c1,hydroxyl
+247442,Remove a amide from the molecule Cc1c(NS(C)(=O)=O)cccc1C(=O)N1CCCCCC1.,Cc1c(NS(C)(=O)=O)cccc1C(=O)N1CCCCCC1,amide
+115986,Modify the molecule CS(=O)(=O)[C@@H]1CCC[C@@H]([NH2+]Cc2cccc(Oc3ccccc3)c2)C1 by removing a benzene_ring.,CS(=O)(=O)[C@@H]1CCC[C@@H]([NH2+]Cc2cccc(Oc3ccccc3)c2)C1,benzene_ring
+88983,Please remove a halo from the molecule Cc1cc(C(=O)N[C@H](C)c2cccnc2)sc1Br.,Cc1cc(C(=O)N[C@H](C)c2cccnc2)sc1Br,halo
+245901,Please remove a benzene_ring from the molecule O=C(Cn1ccnc1)NCc1ccc(-c2ccc(Cl)cc2)o1.,O=C(Cn1ccnc1)NCc1ccc(-c2ccc(Cl)cc2)o1,benzene_ring
+193701,Modify the molecule CC[C@H]1COCCN1Cc1cc(Cl)c(OC)c(OC)c1 by removing a benzene_ring.,CC[C@H]1COCCN1Cc1cc(Cl)c(OC)c(OC)c1,benzene_ring
+95045,Remove a hydroxyl from the molecule Cc1ccc2ccc([C@@H](Nc3cccc[nH+]3)c3ccc(O)cc3)c([O-])c2n1.,Cc1ccc2ccc([C@@H](Nc3cccc[nH+]3)c3ccc(O)cc3)c([O-])c2n1,hydroxyl
+36559,Please remove a amide from the molecule O=C(Nc1ccc2c(c1)N(C(=O)C1CCCC1)CC2)c1ccc2ccccc2n1.,O=C(Nc1ccc2c(c1)N(C(=O)C1CCCC1)CC2)c1ccc2ccccc2n1,amide
+119364,Modify the molecule O=C(NCc1ccc2c(c1)OCO2)c1cn(C[C@H]2CCCO2)cc2c(=O)n(-c3ccccc3)nc1-2 by removing a amide.,O=C(NCc1ccc2c(c1)OCO2)c1cn(C[C@H]2CCCO2)cc2c(=O)n(-c3ccccc3)nc1-2,amide
+141530,Modify the molecule CNC(=O)NCC(=O)Nc1cccc(OCc2cccc(F)c2)c1 by removing a benzene_ring.,CNC(=O)NCC(=O)Nc1cccc(OCc2cccc(F)c2)c1,benzene_ring
+103209,Remove a halo from the molecule Cc1cc(Br)ccc1NC(=O)CCCn1c2ccccc2c(=O)c2ccccc21.,Cc1cc(Br)ccc1NC(=O)CCCn1c2ccccc2c(=O)c2ccccc21,halo
+126856,Please remove a amide from the molecule CCCN[C@@](C)(C[NH+]1C[C@@H](C)[C@@H](C)C1)C(N)=O.,CCCN[C@@](C)(C[NH+]1C[C@@H](C)[C@@H](C)C1)C(N)=O,amide
+103784,Modify the molecule C[C@@H](C(=O)N[C@H](C)c1ccc(S(N)(=O)=O)cc1)[NH+]1CCC(C)(C)C1 by removing a benzene_ring.,C[C@@H](C(=O)N[C@H](C)c1ccc(S(N)(=O)=O)cc1)[NH+]1CCC(C)(C)C1,benzene_ring
+14069,Please remove a amide from the molecule CC[C@@H]1CCCC[C@@H]1N(C)C(=O)Nc1ccc(C(=O)NC)cc1Cl.,CC[C@@H]1CCCC[C@@H]1N(C)C(=O)Nc1ccc(C(=O)NC)cc1Cl,amide
+5633,Remove a halo from the molecule C[C@@H](Oc1ccc([N+](=O)[O-])cc1C=O)C(=O)Nc1ccc(Cl)cc1.,C[C@@H](Oc1ccc([N+](=O)[O-])cc1C=O)C(=O)Nc1ccc(Cl)cc1,halo
+89895,Remove a amine from the molecule Cc1ccc(S(=O)(=O)NCC[NH+]2CCN(c3ccccc3F)CC2)s1.,Cc1ccc(S(=O)(=O)NCC[NH+]2CCN(c3ccccc3F)CC2)s1,amine
+168394,Remove a amide from the molecule C[C@H](Sc1ccc(F)cc1)C(=O)Nc1ccc(OC(F)(F)F)cc1.,C[C@H](Sc1ccc(F)cc1)C(=O)Nc1ccc(OC(F)(F)F)cc1,amide
+32186,Modify the molecule CCN1CCO[C@H](c2nc(-c3cccc(C[NH3+])c3)cs2)C1 by removing a benzene_ring.,CCN1CCO[C@H](c2nc(-c3cccc(C[NH3+])c3)cs2)C1,benzene_ring
+148367,Remove a amide from the molecule CCN(CC)S(=O)(=O)c1ccc(NC(=O)Cc2coc3cc(C)c(C)cc23)cc1.,CCN(CC)S(=O)(=O)c1ccc(NC(=O)Cc2coc3cc(C)c(C)cc23)cc1,amide
+111379,Modify the molecule COc1ccc(C(=O)[C@@H](C#N)c2nnc3n2CCCCC3)cc1Br by removing a benzene_ring.,COc1ccc(C(=O)[C@@H](C#N)c2nnc3n2CCCCC3)cc1Br,benzene_ring
+111720,Modify the molecule CCOc1ccc(CCC(=O)NC2(C(N)=O)CCCC2)cc1 by removing a benzene_ring.,CCOc1ccc(CCC(=O)NC2(C(N)=O)CCCC2)cc1,benzene_ring
+181121,Remove a amide from the molecule CCC[C@@]1(C2CCN(C(=O)c3noc4c3CCCC4)CC2)NC(=O)N(CCc2ccccn2)C1=O.,CCC[C@@]1(C2CCN(C(=O)c3noc4c3CCCC4)CC2)NC(=O)N(CCc2ccccn2)C1=O,amide
+122342,Please remove a amide from the molecule CCn1c(-c2ccc3c(c2)OCCO3)cnc1S[C@H](C)C(=O)NC(=O)NC(C)(C)C.,CCn1c(-c2ccc3c(c2)OCCO3)cnc1S[C@H](C)C(=O)NC(=O)NC(C)(C)C,amide
+144432,Modify the molecule C[C@@H](NC(=O)N[C@@H](c1ccccc1)C(C)(C)C)c1nncn1C by removing a benzene_ring.,C[C@@H](NC(=O)N[C@@H](c1ccccc1)C(C)(C)C)c1nncn1C,benzene_ring
+203720,Please remove a nitrile from the molecule COc1ccc([C@@H]2C(C#N)=C(N)OC3=C2[C@@H](C)N=N3)cc1.,COc1ccc([C@@H]2C(C#N)=C(N)OC3=C2[C@@H](C)N=N3)cc1,nitrile
+175576,Please remove a benzene_ring from the molecule C[NH2+][C@H](Cc1cc(C)cc(C)c1)[C@@H]1C[NH+]2CCN1CC2.,C[NH2+][C@H](Cc1cc(C)cc(C)c1)[C@@H]1C[NH+]2CCN1CC2,benzene_ring
+238005,Modify the molecule COC(=O)C[C@H](NS(C)(=O)=O)C(=O)OC by removing a amine.,COC(=O)C[C@H](NS(C)(=O)=O)C(=O)OC,amine
+15954,Modify the molecule CCS(=O)(=O)NCc1ccc(C(=O)N2C[C@H](C)S[C@@H](C)C2)cc1 by removing a amide.,CCS(=O)(=O)NCc1ccc(C(=O)N2C[C@H](C)S[C@@H](C)C2)cc1,amide
+10481,Please remove a amide from the molecule CC[S@@](=O)CCN1C(=O)NC(C)(C)C1=O.,CC[S@@](=O)CCN1C(=O)NC(C)(C)C1=O,amide
+135868,Modify the molecule O=C(Nc1ccc(CC(=O)N2CCOc3ccccc32)cc1)C1CC1 by removing a amide.,O=C(Nc1ccc(CC(=O)N2CCOc3ccccc32)cc1)C1CC1,amide
+230102,Remove a benzene_ring from the molecule CC(C)CCn1cc(C(=O)NCc2ccc([S@@](C)=O)cc2)nn1.,CC(C)CCn1cc(C(=O)NCc2ccc([S@@](C)=O)cc2)nn1,benzene_ring
+83776,Remove a amine from the molecule O=c1c([N+](=O)[O-])c(NCc2ccsc2)nc2ccccn12.,O=c1c([N+](=O)[O-])c(NCc2ccsc2)nc2ccccn12,amine
+75406,Please remove a amide from the molecule CCOC(=O)[C@H]1CCCC2=c3cccc(C(N)=O)c3=[NH+][C@H]21.,CCOC(=O)[C@H]1CCCC2=c3cccc(C(N)=O)c3=[NH+][C@H]21,amide
+166866,Remove a amide from the molecule Cc1cc(NC(=O)[C@H]2COc3ccccc3O2)c2ncccc2c1.,Cc1cc(NC(=O)[C@H]2COc3ccccc3O2)c2ncccc2c1,amide
+105401,Modify the molecule CC(C)NC(=O)C[NH2+][C@H]1CSCCC1(C)C by removing a amide.,CC(C)NC(=O)C[NH2+][C@H]1CSCCC1(C)C,amide
+44847,Modify the molecule C[C@@H](NC(=O)c1csc(-c2cccs2)n1)[C@H]1CCCO1 by removing a amide.,C[C@@H](NC(=O)c1csc(-c2cccs2)n1)[C@H]1CCCO1,amide
+104150,Please remove a benzene_ring from the molecule CCCCOc1ccc(CN2CCO[C@H](c3nc(C)cs3)C2)cc1.,CCCCOc1ccc(CN2CCO[C@H](c3nc(C)cs3)C2)cc1,benzene_ring
+42934,Remove a halo from the molecule COc1ccc(NC(=O)Cn2c(=O)n(Cc3ccccc3F)c(=O)c3sccc32)cc1OC.,COc1ccc(NC(=O)Cn2c(=O)n(Cc3ccccc3F)c(=O)c3sccc32)cc1OC,halo
+77862,Please remove a benzene_ring from the molecule COc1ccccc1N1CCN(S(=O)(=O)c2ccc3c(c2)OCCO3)CC1.,COc1ccccc1N1CCN(S(=O)(=O)c2ccc3c(c2)OCCO3)CC1,benzene_ring
+234024,Please remove a benzene_ring from the molecule COc1ccc(CN(C)C(=O)c2cn(Cc3cccnc3)nn2)cc1C.,COc1ccc(CN(C)C(=O)c2cn(Cc3cccnc3)nn2)cc1C,benzene_ring
+138233,Modify the molecule CS(=O)(=O)N1CCC2(CC1)Oc1ccc(Br)cc1[C@H]1CC(c3ccncc3)=NN12 by removing a halo.,CS(=O)(=O)N1CCC2(CC1)Oc1ccc(Br)cc1[C@H]1CC(c3ccncc3)=NN12,halo
+108828,Modify the molecule COCCOc1ncccc1C(=O)N1CC[S@@](=O)C(C)(C)C1 by removing a amide.,COCCOc1ncccc1C(=O)N1CC[S@@](=O)C(C)(C)C1,amide
+6922,Please remove a amide from the molecule CO[C@H](CNC(=O)c1ccoc1C)c1ccc(F)cc1.,CO[C@H](CNC(=O)c1ccoc1C)c1ccc(F)cc1,amide
+238584,Please remove a benzene_ring from the molecule Cc1ccccc1C(=O)N[C@@H](C(=O)N1CCOc2ccccc21)C(C)C.,Cc1ccccc1C(=O)N[C@@H](C(=O)N1CCOc2ccccc21)C(C)C,benzene_ring
+37612,Remove a amide from the molecule CCOC(=O)C1CCN(C(=O)CC(F)(F)F)CC1.,CCOC(=O)C1CCN(C(=O)CC(F)(F)F)CC1,amide
+142065,Please remove a benzene_ring from the molecule Cc1noc(C)c1CSc1ccccc1C(=O)N1CCO[C@H](c2ccc(F)cc2)C1.,Cc1noc(C)c1CSc1ccccc1C(=O)N1CCO[C@H](c2ccc(F)cc2)C1,benzene_ring
+2288,Modify the molecule C[C@H](NC(=O)c1ccoc1)C(=O)N1CCN(Cc2ccsc2)CC1 by removing a amide.,C[C@H](NC(=O)c1ccoc1)C(=O)N1CCN(Cc2ccsc2)CC1,amide
+218066,Please remove a amide from the molecule O=C(N[C@@H]1CCCCC[C@H]1C(=O)[O-])[C@@H]1CCOC1.,O=C(N[C@@H]1CCCCC[C@H]1C(=O)[O-])[C@@H]1CCOC1,amide
+75060,Please remove a amide from the molecule C[C@@H](Cc1ccco1)NC(=O)c1ccc2nsnc2c1.,C[C@@H](Cc1ccco1)NC(=O)c1ccc2nsnc2c1,amide
+209700,Modify the molecule CCOC(=O)C1=C(C)N(C)C(=S)N[C@H]1c1cccc(NC(=O)c2ccc(Br)cc2)c1 by removing a benzene_ring.,CCOC(=O)C1=C(C)N(C)C(=S)N[C@H]1c1cccc(NC(=O)c2ccc(Br)cc2)c1,benzene_ring
+20624,Modify the molecule CC(C)(C)OC(=O)N1[C@H]2CC[C@@H]1CN(C(=O)c1cnn3c(-c4ccccc4)ccnc13)CC2 by removing a amide.,CC(C)(C)OC(=O)N1[C@H]2CC[C@@H]1CN(C(=O)c1cnn3c(-c4ccccc4)ccnc13)CC2,amide
+70242,Please remove a hydroxyl from the molecule O[C@@H](COCc1cccs1)Cn1nnc(-c2ccccc2)n1.,O[C@@H](COCc1cccs1)Cn1nnc(-c2ccccc2)n1,hydroxyl
+175845,Remove a amide from the molecule C[C@H](C(=O)Nc1ccc2c(c1)OCO2)N(Cc1cccnc1)C(=O)Cn1nnc2ccccc21.,C[C@H](C(=O)Nc1ccc2c(c1)OCO2)N(Cc1cccnc1)C(=O)Cn1nnc2ccccc21,amide
+144596,Please remove a halo from the molecule Cc1ccc2c(Cl)cc(Cl)c(OCC(=O)N3CCN(c4ncccn4)CC3)c2n1.,Cc1ccc2c(Cl)cc(Cl)c(OCC(=O)N3CCN(c4ncccn4)CC3)c2n1,halo
+34875,Please remove a amide from the molecule Cc1cccc(NC(=O)CN2CC[NH+](C[C@@H]3CCCO3)CC2)c1C.,Cc1cccc(NC(=O)CN2CC[NH+](C[C@@H]3CCCO3)CC2)c1C,amide
+174375,Please remove a benzene_ring from the molecule COc1ccc(N2C(=O)/C(=C/c3c[nH]c4ccccc34)SC2=S)cc1.,COc1ccc(N2C(=O)/C(=C/c3c[nH]c4ccccc34)SC2=S)cc1,benzene_ring
+220349,Remove a benzene_ring from the molecule CC[C@@](C)([NH2+]Cc1ccc(C(N)=O)cc1F)C(=O)[O-].,CC[C@@](C)([NH2+]Cc1ccc(C(N)=O)cc1F)C(=O)[O-],benzene_ring
+108506,Remove a benzene_ring from the molecule Cc1cnc(CNC(=O)NNc2ccccc2Cl)s1.,Cc1cnc(CNC(=O)NNc2ccccc2Cl)s1,benzene_ring
+195113,Modify the molecule CCN[C@]1(C(=O)OC)CC[C@@H](N2CCOC[C@@H]2C)C1 by removing a amine.,CCN[C@]1(C(=O)OC)CC[C@@H](N2CCOC[C@@H]2C)C1,amine
+70066,Please remove a benzene_ring from the molecule CC[NH+]1CCN(c2ccc(F)cc2[N+](=O)[O-])CC1.,CC[NH+]1CCN(c2ccc(F)cc2[N+](=O)[O-])CC1,benzene_ring
+59564,Please remove a amide from the molecule C[C@H](c1ccc(S(N)(=O)=O)cc1)N(C)C(=O)CSCc1cccc(Cl)c1.,C[C@H](c1ccc(S(N)(=O)=O)cc1)N(C)C(=O)CSCc1cccc(Cl)c1,amide
+189964,Remove a amine from the molecule C/C(=C/C(=O)OCc1nc(N)c2ccccc2n1)C1CC1.,C/C(=C/C(=O)OCc1nc(N)c2ccccc2n1)C1CC1,amine
+232002,Please remove a benzene_ring from the molecule O=C(CCn1cc[nH+]c1)Nc1cccc(C(=O)N2CCOC[C@@H]2C2CC2)c1.,O=C(CCn1cc[nH+]c1)Nc1cccc(C(=O)N2CCOC[C@@H]2C2CC2)c1,benzene_ring
+10833,Modify the molecule CSc1cccc(NCc2cccc(C)n2)c1 by removing a benzene_ring.,CSc1cccc(NCc2cccc(C)n2)c1,benzene_ring
+216640,Please remove a hydroxyl from the molecule CC(C)C[NH+](C1CCCC1)[C@H]1C[C@H](C(C)(C)C)CC[C@@H]1O.,CC(C)C[NH+](C1CCCC1)[C@H]1C[C@H](C(C)(C)C)CC[C@@H]1O,hydroxyl
+32675,Please remove a benzene_ring from the molecule COc1cc(=O)n(-c2ccccc2C)nc1C(=O)Nc1ccc(Cl)cc1Cl.,COc1cc(=O)n(-c2ccccc2C)nc1C(=O)Nc1ccc(Cl)cc1Cl,benzene_ring
+186070,Remove a amine from the molecule CCOCC1(CNc2nc(C)nc3c2c(C)nn3C)CCC1.,CCOCC1(CNc2nc(C)nc3c2c(C)nn3C)CCC1,amine
+182297,Modify the molecule COc1ccccc1CSCc1nnc(-c2ccccc2F)o1 by removing a benzene_ring.,COc1ccccc1CSCc1nnc(-c2ccccc2F)o1,benzene_ring
+167780,Modify the molecule COCc1cccc(CNC(=O)c2cc(C(N)=O)cn2C)c1 by removing a benzene_ring.,COCc1cccc(CNC(=O)c2cc(C(N)=O)cn2C)c1,benzene_ring
+63254,Please remove a benzene_ring from the molecule Cc1ccc(Oc2nccn3c(=O)n(CC(=O)N4CCN(c5ccccc5F)CC4)nc23)cc1.,Cc1ccc(Oc2nccn3c(=O)n(CC(=O)N4CCN(c5ccccc5F)CC4)nc23)cc1,benzene_ring
+121266,Remove a halo from the molecule Cc1cc(C(=O)c2ccc(Br)o2)sc1C.,Cc1cc(C(=O)c2ccc(Br)o2)sc1C,halo
+164376,Please remove a benzene_ring from the molecule Clc1ccc(NCc2ccc[nH]2)cc1Br.,Clc1ccc(NCc2ccc[nH]2)cc1Br,benzene_ring
+76198,Remove a benzene_ring from the molecule N#Cc1ccc(CCC(=O)Oc2ccc(Cl)cc2)cc1.,N#Cc1ccc(CCC(=O)Oc2ccc(Cl)cc2)cc1,benzene_ring
+148420,Remove a benzene_ring from the molecule COc1ccc(OC)c(N(CC(=O)N2CCOCC2)S(C)(=O)=O)c1.,COc1ccc(OC)c(N(CC(=O)N2CCOCC2)S(C)(=O)=O)c1,benzene_ring
+139767,Please remove a benzene_ring from the molecule NC(=O)CCn1nc(-c2ccc(F)cc2)c2ccccc2c1=O.,NC(=O)CCn1nc(-c2ccc(F)cc2)c2ccccc2c1=O,benzene_ring
+204894,Please remove a amide from the molecule CCn1c(C(=O)N[C@H]2CCC[C@H](S(C)(=O)=O)C2)cc2ccccc21.,CCn1c(C(=O)N[C@H]2CCC[C@H](S(C)(=O)=O)C2)cc2ccccc21,amide
+225319,Please remove a benzene_ring from the molecule O=C(Cc1cn2ccccc2[nH+]1)Nc1cccc(F)c1.,O=C(Cc1cn2ccccc2[nH+]1)Nc1cccc(F)c1,benzene_ring
+119625,Remove a benzene_ring from the molecule O=C(C[C@H]1CCS(=O)(=O)C1)Oc1cccc(Oc2ccccc2)c1.,O=C(C[C@H]1CCS(=O)(=O)C1)Oc1cccc(Oc2ccccc2)c1,benzene_ring
+87453,Modify the molecule CCc1nn(C)cc1NC(=O)C(=O)NCC1(c2ccccc2)CC1 by removing a amide.,CCc1nn(C)cc1NC(=O)C(=O)NCC1(c2ccccc2)CC1,amide
+183959,Remove a amine from the molecule CSc1nccnc1CNC[C@@H]1CCCC[NH2+]1.,CSc1nccnc1CNC[C@@H]1CCCC[NH2+]1,amine
+114463,Remove a halo from the molecule COc1ccc(NC(=O)NCCc2cccc(Cl)c2)cc1NC(C)=O.,COc1ccc(NC(=O)NCCc2cccc(Cl)c2)cc1NC(C)=O,halo
+79386,Remove a benzene_ring from the molecule O=C(OCc1cccc(F)c1)c1ccc(N2CCNC2=O)cc1.,O=C(OCc1cccc(F)c1)c1ccc(N2CCNC2=O)cc1,benzene_ring
+242558,Please remove a halo from the molecule COc1ccc([N+](=O)[O-])cc1S(=O)(=O)[N-]c1ccc(Cl)cc1.,COc1ccc([N+](=O)[O-])cc1S(=O)(=O)[N-]c1ccc(Cl)cc1,halo
+162515,Remove a amide from the molecule Cc1cc(NC(=O)CSc2ccc(S(=O)(=O)N3CCCC3)cn2)no1.,Cc1cc(NC(=O)CSc2ccc(S(=O)(=O)N3CCCC3)cn2)no1,amide
+135481,Remove a benzene_ring from the molecule CC(C)C(=O)NC[C@H]1CCCN(C(=O)c2cc(F)cc(F)c2)C1.,CC(C)C(=O)NC[C@H]1CCCN(C(=O)c2cc(F)cc(F)c2)C1,benzene_ring
+227144,Remove a benzene_ring from the molecule COc1cc(OC)cc(C(=O)Nn2cc(C(=O)NCc3ccccn3)c3ccccc3c2=O)c1.,COc1cc(OC)cc(C(=O)Nn2cc(C(=O)NCc3ccccn3)c3ccccc3c2=O)c1,benzene_ring
+153260,Modify the molecule Cc1ccccc1O[C@H](C)CNC(=O)CN1C(=O)c2ccccc2C1=O by removing a benzene_ring.,Cc1ccccc1O[C@H](C)CNC(=O)CN1C(=O)c2ccccc2C1=O,benzene_ring
+15766,Remove a amide from the molecule CC(=O)N1Cc2cc(C)ccc2OC2(CCN(C(=O)c3cc[nH]n3)CC2)C1.,CC(=O)N1Cc2cc(C)ccc2OC2(CCN(C(=O)c3cc[nH]n3)CC2)C1,amide
+193460,Remove a halo from the molecule S=C1SCCN1CN1CCc2ccc(Cl)cc2C1.,S=C1SCCN1CN1CCc2ccc(Cl)cc2C1,halo
+155725,Please remove a benzene_ring from the molecule C[C@@H](NC(=O)C(C)(C)NC(=O)Nc1ccccc1)c1ccc(Cl)s1.,C[C@@H](NC(=O)C(C)(C)NC(=O)Nc1ccccc1)c1ccc(Cl)s1,benzene_ring
+83527,Remove a halo from the molecule NC(=O)[C@H]1CCN(C(=O)[C@H]2C[C@@H]2c2ccccc2Cl)C1.,NC(=O)[C@H]1CCN(C(=O)[C@H]2C[C@@H]2c2ccccc2Cl)C1,halo
+236372,Modify the molecule CC[C@@H](Nc1ccc2nnc(-c3ccccc3F)n2n1)c1noc(C)n1 by removing a amine.,CC[C@@H](Nc1ccc2nnc(-c3ccccc3F)n2n1)c1noc(C)n1,amine
+218086,Modify the molecule Cc1cccn2cc(C[S@](=O)[C@H](C)C(=O)NCc3ccccc3)nc12 by removing a benzene_ring.,Cc1cccn2cc(C[S@](=O)[C@H](C)C(=O)NCc3ccccc3)nc12,benzene_ring
+15200,Please remove a nitrile from the molecule N#Cc1ccc(CCC(=O)N[C@@H](Cc2ccccc2)C2CC2)cc1.,N#Cc1ccc(CCC(=O)N[C@@H](Cc2ccccc2)C2CC2)cc1,nitrile
+233755,Modify the molecule CCCCNC(=O)NNC(=O)Cc1cccs1 by removing a amide.,CCCCNC(=O)NNC(=O)Cc1cccs1,amide
+11340,Modify the molecule COc1ccc([C@@H](C)N[C@H]2CCN(CC(F)(F)F)C2=O)c(OC)c1 by removing a halo.,COc1ccc([C@@H](C)N[C@H]2CCN(CC(F)(F)F)C2=O)c(OC)c1,halo
+185275,Remove a benzene_ring from the molecule Cc1nc(-c2cccc(C[NH2+][C@H](C)c3cnn(C(C)C)c3)c2)n[nH]1.,Cc1nc(-c2cccc(C[NH2+][C@H](C)c3cnn(C(C)C)c3)c2)n[nH]1,benzene_ring
+89840,Modify the molecule [NH3+][C@@H](c1ccn(CCC(F)(F)F)c1)C1CC1 by removing a halo.,[NH3+][C@@H](c1ccn(CCC(F)(F)F)c1)C1CC1,halo
+118923,Modify the molecule CNc1cc[nH+]c(Cn2nccc2C)c1 by removing a amine.,CNc1cc[nH+]c(Cn2nccc2C)c1,amine
+192259,Modify the molecule CC(C)(C)c1ccc(OCC(=O)N/N=C/c2ccc(N3CCOCC3)cc2)cc1 by removing a benzene_ring.,CC(C)(C)c1ccc(OCC(=O)N/N=C/c2ccc(N3CCOCC3)cc2)cc1,benzene_ring
+196590,Remove a benzene_ring from the molecule Fc1ccc([C@H]2OCC[C@H]2CCl)cc1F.,Fc1ccc([C@H]2OCC[C@H]2CCl)cc1F,benzene_ring
+111272,Modify the molecule COc1ccc(/C=C(\C)c2ccncc2)cc1 by removing a benzene_ring.,COc1ccc(/C=C(\C)c2ccncc2)cc1,benzene_ring
+92090,Remove a amide from the molecule COc1ccc([C@H]2[C@@H](C(=O)NCc3ccc(F)cc3)c3ccccc3C(=O)N2C)cc1.,COc1ccc([C@H]2[C@@H](C(=O)NCc3ccc(F)cc3)c3ccccc3C(=O)N2C)cc1,amide
+122887,Remove a amine from the molecule COc1ccc([C@@H]2SCCN2C(=S)Nc2ccc(Cl)cc2)cc1.,COc1ccc([C@@H]2SCCN2C(=S)Nc2ccc(Cl)cc2)cc1,amine
+52051,Please remove a halo from the molecule NS(=O)(=O)CC1CC[NH+](Cc2ncc(-c3ccccc3Cl)o2)CC1.,NS(=O)(=O)CC1CC[NH+](Cc2ncc(-c3ccccc3Cl)o2)CC1,halo
+97489,Modify the molecule CCNS(=O)(=O)[C@@H]1CC[NH+](CC(=O)Nc2ccccc2C(C)(C)C)C1 by removing a benzene_ring.,CCNS(=O)(=O)[C@@H]1CC[NH+](CC(=O)Nc2ccccc2C(C)(C)C)C1,benzene_ring
+111963,Please remove a amide from the molecule O=C1[C@H]2[C@H]3C=C[C@H](CC3)[C@H]2C(=O)N1/N=C/c1cn(Cc2ccccc2Cl)c2ccccc12.,O=C1[C@H]2[C@H]3C=C[C@H](CC3)[C@H]2C(=O)N1/N=C/c1cn(Cc2ccccc2Cl)c2ccccc12,amide
+96974,Modify the molecule CCOC(=O)Cn1c(=O)n(CCc2ccccc2)c(=O)c2c3c(sc21)COC(C)(C)C3 by removing a benzene_ring.,CCOC(=O)Cn1c(=O)n(CCc2ccccc2)c(=O)c2c3c(sc21)COC(C)(C)C3,benzene_ring
+99146,Remove a halo from the molecule Cn1c(CNc2ccc(C(N)=O)c(F)c2)nnc1-c1ccccc1.,Cn1c(CNc2ccc(C(N)=O)c(F)c2)nnc1-c1ccccc1,halo
+212323,Modify the molecule Cc1ccc(NC(=O)[C@@H](C)N2CCO[C@H](c3ccccc3)C2)c(F)c1 by removing a halo.,Cc1ccc(NC(=O)[C@@H](C)N2CCO[C@H](c3ccccc3)C2)c(F)c1,halo
+231545,Please remove a benzene_ring from the molecule Cc1ccc(C)c(NC(=O)N2C[C@@H](C)C[C@@H](C)C2)c1.,Cc1ccc(C)c(NC(=O)N2C[C@@H](C)C[C@@H](C)C2)c1,benzene_ring
+66859,Modify the molecule C[C@H](C[NH+]1CCCCC1)NC(=O)N1CCC(c2ccc(O)cc2)CC1 by removing a hydroxyl.,C[C@H](C[NH+]1CCCCC1)NC(=O)N1CCC(c2ccc(O)cc2)CC1,hydroxyl
+187292,Please remove a amide from the molecule C[C@H]1c2cc3c(cc2C2(CCCC2)CN1C(=O)c1cccc(C#N)c1)OCCO3.,C[C@H]1c2cc3c(cc2C2(CCCC2)CN1C(=O)c1cccc(C#N)c1)OCCO3,amide
+53305,Modify the molecule C[C@H]1OCC[C@@H]1C(=O)N1CCC[NH+](CC(=O)N(C)C)CC1 by removing a amide.,C[C@H]1OCC[C@@H]1C(=O)N1CCC[NH+](CC(=O)N(C)C)CC1,amide
+19537,Please remove a amide from the molecule Cc1ccc(C(=O)NNC(=O)Cc2ccc(-c3ccccc3)cc2)o1.,Cc1ccc(C(=O)NNC(=O)Cc2ccc(-c3ccccc3)cc2)o1,amide
+6154,Remove a benzene_ring from the molecule C[C@H](CC(=O)NN1C(=O)N[C@](C)(c2ccccc2)C1=O)c1ccccc1.,C[C@H](CC(=O)NN1C(=O)N[C@](C)(c2ccccc2)C1=O)c1ccccc1,benzene_ring
+151442,Remove a amine from the molecule Cc1ccc(CNc2cccc(OCCCC#N)c2)o1.,Cc1ccc(CNc2cccc(OCCCC#N)c2)o1,amine
+150763,Modify the molecule Cn1cc(C(=O)Nc2cc(Cl)ccc2[N-]S(=O)(=O)c2ccccc2F)cn1 by removing a benzene_ring.,Cn1cc(C(=O)Nc2cc(Cl)ccc2[N-]S(=O)(=O)c2ccccc2F)cn1,benzene_ring
+201939,Remove a amide from the molecule CC(=O)N[C@@H]1CCN(c2nc(C)nc3c2c(C)nn3C)C1.,CC(=O)N[C@@H]1CCN(c2nc(C)nc3c2c(C)nn3C)C1,amide
+62437,Please remove a benzene_ring from the molecule Cc1cccc(C)c1NC(=O)C[NH+](C)CC(=O)N1CCC[C@H]2CCCC[C@@H]21.,Cc1cccc(C)c1NC(=O)C[NH+](C)CC(=O)N1CCC[C@H]2CCCC[C@@H]21,benzene_ring
+49395,Modify the molecule CN(C)[C@@H](C[NH2+]CC(=O)N1CCc2ccccc21)c1ccccc1 by removing a benzene_ring.,CN(C)[C@@H](C[NH2+]CC(=O)N1CCc2ccccc21)c1ccccc1,benzene_ring
+210665,Remove a halo from the molecule C[C@H]1CN(C(C)(C)CNC(=O)CSCC(F)(F)F)C[C@@H](C)O1.,C[C@H]1CN(C(C)(C)CNC(=O)CSCC(F)(F)F)C[C@@H](C)O1,halo
+247757,Please remove a halo from the molecule C[C@H](NC(=O)[C@H](C)Oc1ccccc1C(F)(F)F)C(=O)N(C)C.,C[C@H](NC(=O)[C@H](C)Oc1ccccc1C(F)(F)F)C(=O)N(C)C,halo
+97656,Please remove a benzene_ring from the molecule CCOC(=O)[C@@H]1CCCN(C(=O)N[C@@H](C)c2ccccc2)C1.,CCOC(=O)[C@@H]1CCCN(C(=O)N[C@@H](C)c2ccccc2)C1,benzene_ring
+217601,Please remove a amide from the molecule CC(C)OCc1ccc(C(=O)N2CCN(S(=O)(=O)c3ccc(Br)s3)CC2)cc1.,CC(C)OCc1ccc(C(=O)N2CCN(S(=O)(=O)c3ccc(Br)s3)CC2)cc1,amide
+201961,Please remove a hydroxyl from the molecule O=C([O-])c1ccc(/N=C\c2ccccc2O)cc1.,O=C([O-])c1ccc(/N=C\c2ccccc2O)cc1,hydroxyl
+153293,Please remove a nitrile from the molecule COC[C@@](C)(C#N)NC(=O)c1ccc(Br)cc1Br.,COC[C@@](C)(C#N)NC(=O)c1ccc(Br)cc1Br,nitrile
+179824,Modify the molecule CCn1ccnc1CNC(=O)c1cn(Cc2ccccc2F)nn1 by removing a benzene_ring.,CCn1ccnc1CNC(=O)c1cn(Cc2ccccc2F)nn1,benzene_ring
+150335,Modify the molecule Cc1ccc(-c2csc3ncn(CC(=O)Nc4ccc(F)cc4F)c(=O)c23)cc1 by removing a halo.,Cc1ccc(-c2csc3ncn(CC(=O)Nc4ccc(F)cc4F)c(=O)c23)cc1,halo
+154548,Remove a amide from the molecule CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(CCO)S(C)(=O)=O)c(C3CC3)cc12.,CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(N(CCO)S(C)(=O)=O)c(C3CC3)cc12,amide
+64377,Remove a amine from the molecule N#Cc1ccc([C@H]2Nc3ccccc3C(=O)N2Cc2ccc3c(c2)OCO3)cc1.,N#Cc1ccc([C@H]2Nc3ccccc3C(=O)N2Cc2ccc3c(c2)OCO3)cc1,amine
+127673,Modify the molecule COC(=O)C1=C[C@@H](S(=O)(=O)NC[C@H]2CCCO2)C=N1 by removing a amine.,COC(=O)C1=C[C@@H](S(=O)(=O)NC[C@H]2CCCO2)C=N1,amine
+165405,Remove a amide from the molecule COCCCNC(=O)C(=O)c1c[nH]c2ccccc12.,COCCCNC(=O)C(=O)c1c[nH]c2ccccc12,amide
+98988,Modify the molecule BrCC1(C[C@@H]2C[C@H]3CC[C@@H]2C3)CCCC1 by removing a halo.,BrCC1(C[C@@H]2C[C@H]3CC[C@@H]2C3)CCCC1,halo
+234627,Please remove a amide from the molecule COc1ccccc1N1CC[C@@H]([NH2+][C@@H](C)C[C@H]2CCCO2)C1=O.,COc1ccccc1N1CC[C@@H]([NH2+][C@@H](C)C[C@H]2CCCO2)C1=O,amide
+211636,Please remove a amide from the molecule COc1ccc(CCCNC(=O)[C@@H]2CN(C)CCO2)cc1OC.,COc1ccc(CCCNC(=O)[C@@H]2CN(C)CCO2)cc1OC,amide
+34888,Modify the molecule O=C(Cc1cc([O-])nc(SCc2ccc(F)cc2)n1)N1CCN(c2cccc[nH+]2)CC1 by removing a benzene_ring.,O=C(Cc1cc([O-])nc(SCc2ccc(F)cc2)n1)N1CCN(c2cccc[nH+]2)CC1,benzene_ring
+184353,Modify the molecule Cc1ccccc1C(=O)Nc1cc(NC(=O)c2ccccc2C)cc(C(=O)[O-])c1 by removing a amide.,Cc1ccccc1C(=O)Nc1cc(NC(=O)c2ccccc2C)cc(C(=O)[O-])c1,amide
+165736,Remove a hydroxyl from the molecule OC[C@@]1([NH2+]C2CC2)CCC[C@H]1CCOC1CCCC1.,OC[C@@]1([NH2+]C2CC2)CCC[C@H]1CCOC1CCCC1,hydroxyl
+19602,Please remove a benzene_ring from the molecule COC(=O)c1ccc(NCc2cccc([N+](=O)[O-])c2)cc1.,COC(=O)c1ccc(NCc2cccc([N+](=O)[O-])c2)cc1,benzene_ring
+243958,Remove a amide from the molecule O=C(NC[C@H]1COc2ccccc2C1)[C@H]1COc2ccccc2O1.,O=C(NC[C@H]1COc2ccccc2C1)[C@H]1COc2ccccc2O1,amide
+115081,Please remove a amine from the molecule O=[N+]([O-])c1cnc(NCCCn2cc[nH+]c2)c(Br)c1.,O=[N+]([O-])c1cnc(NCCCn2cc[nH+]c2)c(Br)c1,amine
+10327,Remove a amide from the molecule Cc1cc(NC(=O)C[S@](=O)[C@H](C)c2ccc(Cl)c(Cl)c2)no1.,Cc1cc(NC(=O)C[S@](=O)[C@H](C)c2ccc(Cl)c(Cl)c2)no1,amide
+173716,Please remove a amide from the molecule CN(CC(=O)N(CCC(F)(F)F)C1CCC1)c1ncnc2[nH]cnc12.,CN(CC(=O)N(CCC(F)(F)F)C1CCC1)c1ncnc2[nH]cnc12,amide
+141388,Remove a amine from the molecule CC(C)NC(=O)C[NH+](C)Cc1nc2ccc(N)cc2o1.,CC(C)NC(=O)C[NH+](C)Cc1nc2ccc(N)cc2o1,amine
+104059,Please remove a amide from the molecule Cc1nc2ccc(NC(=O)C(=O)NC3CC[NH+](CC4CCCCC4)CC3)cc2o1.,Cc1nc2ccc(NC(=O)C(=O)NC3CC[NH+](CC4CCCCC4)CC3)cc2o1,amide
+48009,Remove a amide from the molecule COC(=O)N1CCC(CNC(=O)[C@H]2CC(=O)N(c3ccc(C)c(C)c3)C2)CC1.,COC(=O)N1CCC(CNC(=O)[C@H]2CC(=O)N(c3ccc(C)c(C)c3)C2)CC1,amide
+92079,Please remove a amide from the molecule CC(C)n1cc(C(=O)Nc2ccc3cc[nH]c3c2)c2ccccc2c1=O.,CC(C)n1cc(C(=O)Nc2ccc3cc[nH]c3c2)c2ccccc2c1=O,amide
+208881,Modify the molecule C[C@@H]1CC(C(=O)N2CCC[C@@H]2C(=O)N2CCN(C)CC2)C[C@@H](C)O1 by removing a amide.,C[C@@H]1CC(C(=O)N2CCC[C@@H]2C(=O)N2CCN(C)CC2)C[C@@H](C)O1,amide
+35796,Modify the molecule COc1cccnc1NCc1cnc(-c2ccccn2)s1 by removing a amine.,COc1cccnc1NCc1cnc(-c2ccccn2)s1,amine
+10915,Modify the molecule N#C[C@@H]1CCCC[C@H]1OC(=O)CCc1cc(Cl)cs1 by removing a nitrile.,N#C[C@@H]1CCCC[C@H]1OC(=O)CCc1cc(Cl)cs1,nitrile
+77724,Remove a amide from the molecule O=C(Cc1cccc2ccccc12)N[C@H](c1ccccc1)c1ccncc1.,O=C(Cc1cccc2ccccc12)N[C@H](c1ccccc1)c1ccncc1,amide
+498,Remove a benzene_ring from the molecule COC(=O)[C@H]1CCC[C@H]1NC(=O)Nc1ccc(C)cc1C.,COC(=O)[C@H]1CCC[C@H]1NC(=O)Nc1ccc(C)cc1C,benzene_ring
+60056,Please remove a halo from the molecule O=C(COC(=O)c1cccs1)Nc1cc(S(=O)(=O)N2CCCC2)ccc1Cl.,O=C(COC(=O)c1cccs1)Nc1cc(S(=O)(=O)N2CCCC2)ccc1Cl,halo
+48484,Modify the molecule CCCOc1ccc([C@@H]([NH2+]C)c2c(F)cccc2F)cc1 by removing a benzene_ring.,CCCOc1ccc([C@@H]([NH2+]C)c2c(F)cccc2F)cc1,benzene_ring
+221387,Modify the molecule O=C(CSc1nc(-c2ccccc2)c[nH]1)N1CCN(c2ccccc2F)CC1 by removing a benzene_ring.,O=C(CSc1nc(-c2ccccc2)c[nH]1)N1CCN(c2ccccc2F)CC1,benzene_ring
+5474,Modify the molecule O=C(NCc1ccccc1F)c1ccc(S(=O)(=O)[C@@H]2CCS(=O)(=O)C2)cc1 by removing a amide.,O=C(NCc1ccccc1F)c1ccc(S(=O)(=O)[C@@H]2CCS(=O)(=O)C2)cc1,amide
+25846,Modify the molecule C[C@@H]1CN(C(=O)CSc2nnc(-c3ccccc3)n2N)C[C@@H](C)O1 by removing a amide.,C[C@@H]1CN(C(=O)CSc2nnc(-c3ccccc3)n2N)C[C@@H](C)O1,amide
+109447,Please remove a amide from the molecule Cc1cc(NC(=O)CSc2nc3c(cnn3-c3cccc(Cl)c3)c(=O)[nH]2)no1.,Cc1cc(NC(=O)CSc2nc3c(cnn3-c3cccc(Cl)c3)c(=O)[nH]2)no1,amide
+100931,Please remove a amide from the molecule C[C@@H]1CCCC[C@H]1NC(=O)Cc1coc2cc3c(cc12)CCC3.,C[C@@H]1CCCC[C@H]1NC(=O)Cc1coc2cc3c(cc12)CCC3,amide
+122144,Remove a benzene_ring from the molecule CCc1noc(CN(C)C(=O)Nc2ccc(N3CCO[C@@H](C)C3)cc2)n1.,CCc1noc(CN(C)C(=O)Nc2ccc(N3CCO[C@@H](C)C3)cc2)n1,benzene_ring
+91803,Modify the molecule Cc1cccc(C)c1OC[C@H](O)Cn1c([C@H]2CC(=O)N(c3ccccc3F)C2)nc2ccccc21 by removing a hydroxyl.,Cc1cccc(C)c1OC[C@H](O)Cn1c([C@H]2CC(=O)N(c3ccccc3F)C2)nc2ccccc21,hydroxyl
+210960,Please remove a nitrile from the molecule N#Cc1ccc(C[NH+]2CC[C@@H](OCCCc3ccccc3)C2)cc1.,N#Cc1ccc(C[NH+]2CC[C@@H](OCCCc3ccccc3)C2)cc1,nitrile
+30335,Remove a nitrile from the molecule CC(C)[C@H](C)SCC(=O)NC1(C#N)CCCCCC1.,CC(C)[C@H](C)SCC(=O)NC1(C#N)CCCCCC1,nitrile
+195881,Modify the molecule COc1ccc(CC(=O)NC[C@H](c2cccs2)[NH+]2CCCCCC2)cc1 by removing a amide.,COc1ccc(CC(=O)NC[C@H](c2cccs2)[NH+]2CCCCCC2)cc1,amide
+50591,Remove a benzene_ring from the molecule COc1ccccc1[C@H]([NH2+]Cc1cnn(C)c1C)C1CCCC1.,COc1ccccc1[C@H]([NH2+]Cc1cnn(C)c1C)C1CCCC1,benzene_ring
+22650,Remove a hydroxyl from the molecule C[C@@H](CCCO)NC(=O)N1CCN(c2ncnc3sccc23)CC1.,C[C@@H](CCCO)NC(=O)N1CCN(c2ncnc3sccc23)CC1,hydroxyl
+87977,Modify the molecule Cc1cc(CSc2ncccc2C(=O)Nc2ccc3oc(C)nc3c2)no1 by removing a amide.,Cc1cc(CSc2ncccc2C(=O)Nc2ccc3oc(C)nc3c2)no1,amide
+75699,Please remove a halo from the molecule O=C(COc1ccc(Oc2ccccc2)cc1)Nc1cc(N2CCCC2=O)ccc1Cl.,O=C(COc1ccc(Oc2ccccc2)cc1)Nc1cc(N2CCCC2=O)ccc1Cl,halo
+17122,Modify the molecule COc1cccc2c1C(=O)O[C@H]2S(=O)(=O)c1ccccc1 by removing a benzene_ring.,COc1cccc2c1C(=O)O[C@H]2S(=O)(=O)c1ccccc1,benzene_ring
+176172,Modify the molecule COc1ccc(C2(C(=O)N3CCC[C@@H](c4ccn[nH]4)C3)CCCC2)cc1 by removing a amide.,COc1ccc(C2(C(=O)N3CCC[C@@H](c4ccn[nH]4)C3)CCCC2)cc1,amide
+16075,Remove a halo from the molecule C[NH2+][C@H]1c2cc(F)c(F)cc2[S@](=O)[C@@H](C)[C@H]1C.,C[NH2+][C@H]1c2cc(F)c(F)cc2[S@](=O)[C@@H](C)[C@H]1C,halo
+539,Modify the molecule COc1ccccc1CNC(=O)c1cc2sccc2n1Cc1cccc(F)c1 by removing a halo.,COc1ccccc1CNC(=O)c1cc2sccc2n1Cc1cccc(F)c1,halo
+165374,Modify the molecule COc1ccc(Br)c(C(=O)N2CCC3(CC2)OCCN3S(=O)(=O)c2ccccc2)c1 by removing a amide.,COc1ccc(Br)c(C(=O)N2CCC3(CC2)OCCN3S(=O)(=O)c2ccccc2)c1,amide
+48039,Please remove a amine from the molecule Nc1ccc(=O)n(CCCN2CCN3C(=O)NC[C@@H]3C2)c1.,Nc1ccc(=O)n(CCCN2CCN3C(=O)NC[C@@H]3C2)c1,amine
+3375,Please remove a benzene_ring from the molecule COc1cc(NC(=O)c2cccc(-c3ccc(N4CCCC4)nn3)c2)cc(OC)c1.,COc1cc(NC(=O)c2cccc(-c3ccc(N4CCCC4)nn3)c2)cc(OC)c1,benzene_ring
+227309,Modify the molecule C[C@@H](OC(=O)c1cn(C)c2ccccc12)C(=O)Nc1ccc(S(N)(=O)=O)cc1 by removing a amide.,C[C@@H](OC(=O)c1cn(C)c2ccccc12)C(=O)Nc1ccc(S(N)(=O)=O)cc1,amide
+10844,Remove a benzene_ring from the molecule C[NH2+][C@H](CCO)c1ccccc1.,C[NH2+][C@H](CCO)c1ccccc1,benzene_ring
+116944,Modify the molecule Nc1ccc(S[C@@H](C(=O)[O-])C2CC2)cc1F by removing a amine.,Nc1ccc(S[C@@H](C(=O)[O-])C2CC2)cc1F,amine
+187003,Modify the molecule CC[C@H](C)C(=O)NCC(=O)Nc1ccc(OC)c2ncccc12 by removing a amide.,CC[C@H](C)C(=O)NCC(=O)Nc1ccc(OC)c2ncccc12,amide
+195491,Modify the molecule CC[C@](C)([NH2+]CC(=O)Nc1c(C)n[nH]c1C)C(=O)[O-] by removing a amide.,CC[C@](C)([NH2+]CC(=O)Nc1c(C)n[nH]c1C)C(=O)[O-],amide
+44420,Modify the molecule O=C(NCCCNC(=O)c1ccnc2ncccc12)c1cccc(F)c1 by removing a amide.,O=C(NCCCNC(=O)c1ccnc2ncccc12)c1cccc(F)c1,amide
+156349,Remove a benzene_ring from the molecule C[C@H](NC(=O)c1cnc(Oc2ccccc2)cn1)[C@@H]1CCOC1.,C[C@H](NC(=O)c1cnc(Oc2ccccc2)cn1)[C@@H]1CCOC1,benzene_ring
+206280,Please remove a benzene_ring from the molecule CCc1cc(=O)n(CC(=O)Nc2ccc(OC)cc2OC)c(-c2cccc(F)c2)n1.,CCc1cc(=O)n(CC(=O)Nc2ccc(OC)cc2OC)c(-c2cccc(F)c2)n1,benzene_ring
+176923,Remove a benzene_ring from the molecule CNC(=O)c1ccc(CNC(=O)N[C@@H]2C[C@H](C)CC[C@H]2C(C)C)cc1.,CNC(=O)c1ccc(CNC(=O)N[C@@H]2C[C@H](C)CC[C@H]2C(C)C)cc1,benzene_ring
+7835,Remove a nitrile from the molecule C[C@@H]1CC[C@](C#N)(C2(O)CCOCC2)C1.,C[C@@H]1CC[C@](C#N)(C2(O)CCOCC2)C1,nitrile
+148039,Remove a amide from the molecule CCCn1c(C[NH+]2CCC(NC(=O)c3ccoc3C)CC2)nc2ccccc21.,CCCn1c(C[NH+]2CCC(NC(=O)c3ccoc3C)CC2)nc2ccccc21,amide
+200849,Modify the molecule CC(=O)c1c(C)[nH]c(C(=O)N[C@@]2(C)CCS(=O)(=O)C2)c1C by removing a amide.,CC(=O)c1c(C)[nH]c(C(=O)N[C@@]2(C)CCS(=O)(=O)C2)c1C,amide
+80831,Modify the molecule COc1ccc(N2CCN([C@@H]3CC(=O)N(c4ccc(C(F)(F)F)cc4)C3=O)CC2)cc1 by removing a benzene_ring.,COc1ccc(N2CCN([C@@H]3CC(=O)N(c4ccc(C(F)(F)F)cc4)C3=O)CC2)cc1,benzene_ring
+100316,Please remove a benzene_ring from the molecule CC[C@@H](C)NC(=O)NCc1ccc(C[NH+](C)C)cc1.,CC[C@@H](C)NC(=O)NCc1ccc(C[NH+](C)C)cc1,benzene_ring
+158075,Please remove a hydroxyl from the molecule Cc1ccccc1[C@H]([NH3+])CO.,Cc1ccccc1[C@H]([NH3+])CO,hydroxyl
+9214,Remove a amide from the molecule CC(C)CN1CCO[C@@H](CNC(=O)CN2CC[S@@](=O)C(C)(C)C2)C1.,CC(C)CN1CCO[C@@H](CNC(=O)CN2CC[S@@](=O)C(C)(C)C2)C1,amide
+190180,Remove a amide from the molecule O=C(NC1CCCCC1)[C@H]1CC(c2c(F)cccc2Cl)=NO1.,O=C(NC1CCCCC1)[C@H]1CC(c2c(F)cccc2Cl)=NO1,amide
+215702,Modify the molecule CC(C)[C@@H](NC(=O)c1ccccc1F)C(=O)N[C@@H]1CCCC[C@@H]1C by removing a halo.,CC(C)[C@@H](NC(=O)c1ccccc1F)C(=O)N[C@@H]1CCCC[C@@H]1C,halo
+249128,Please remove a amide from the molecule O=C(NCCNC(=O)[C@@H]1CC=CCC1)[C@@H]1CC=CCC1.,O=C(NCCNC(=O)[C@@H]1CC=CCC1)[C@@H]1CC=CCC1,amide
+111050,Remove a amide from the molecule CC(C)CN1CCN(C(=O)Cc2c[nH]c(=O)n(C)c2=O)[C@H](C)C1=O.,CC(C)CN1CCN(C(=O)Cc2c[nH]c(=O)n(C)c2=O)[C@H](C)C1=O,amide
+171678,Modify the molecule N#Cc1ccc(COC(=O)CCc2nc(-c3ncccn3)no2)cc1 by removing a benzene_ring.,N#Cc1ccc(COC(=O)CCc2nc(-c3ncccn3)no2)cc1,benzene_ring
+62363,Remove a halo from the molecule Cc1[nH]nc(C(N)=O)c1NC(=O)[C@H](C)c1ccc(Br)s1.,Cc1[nH]nc(C(N)=O)c1NC(=O)[C@H](C)c1ccc(Br)s1,halo
+155275,Modify the molecule CNC(=O)CN(C)C(=O)NCCOCC(=O)[O-] by removing a amide.,CNC(=O)CN(C)C(=O)NCCOCC(=O)[O-],amide
+101634,Modify the molecule Cc1ccc(S(=O)(=O)N/N=C/c2cccs2)cc1 by removing a benzene_ring.,Cc1ccc(S(=O)(=O)N/N=C/c2cccs2)cc1,benzene_ring
+5987,Remove a benzene_ring from the molecule Cc1ccccc1Cn1cc(C(=O)N2CCC([C@H](O)CCc3ccccc3)CC2)nn1.,Cc1ccccc1Cn1cc(C(=O)N2CCC([C@H](O)CCc3ccccc3)CC2)nn1,benzene_ring
+179374,Please remove a halo from the molecule C[C@H](NC(=O)c1ccccc1Cl)[C@H]1COc2ccccc2O1.,C[C@H](NC(=O)c1ccccc1Cl)[C@H]1COc2ccccc2O1,halo
+88185,Modify the molecule COCCn1ccc2ccc(NC(=O)c3cccc(-n4cnnn4)c3)cc21 by removing a amide.,COCCn1ccc2ccc(NC(=O)c3cccc(-n4cnnn4)c3)cc21,amide
+223764,Please remove a amide from the molecule CN1CCO[C@@H](C(=O)NCc2ccc(Cn3ccccc3=O)cc2)C1.,CN1CCO[C@@H](C(=O)NCc2ccc(Cn3ccccc3=O)cc2)C1,amide
+246624,Modify the molecule O=C(NCc1cccnc1)C1CC[NH+](C2CC[NH+](CC3CCCC3)CC2)CC1 by removing a amide.,O=C(NCc1cccnc1)C1CC[NH+](C2CC[NH+](CC3CCCC3)CC2)CC1,amide
+220927,Please remove a amide from the molecule O=C(Nc1ccc(Cl)cc1F)[C@@H]1CCCN1C(=O)c1cc(Cl)ccc1Cl.,O=C(Nc1ccc(Cl)cc1F)[C@@H]1CCCN1C(=O)c1cc(Cl)ccc1Cl,amide
+45825,Remove a amide from the molecule Cc1ccc([C@H](CNC(=O)[C@@H]2CSCN2C(=O)CC(C)(C)C)[NH+](C)C)cc1.,Cc1ccc([C@H](CNC(=O)[C@@H]2CSCN2C(=O)CC(C)(C)C)[NH+](C)C)cc1,amide
+78748,Remove a benzene_ring from the molecule Cc1nc(C[NH2+]Cc2ccc(N3CCC[C@H](C(N)=O)C3)cc2)cs1.,Cc1nc(C[NH2+]Cc2ccc(N3CCC[C@H](C(N)=O)C3)cc2)cs1,benzene_ring
+183600,Modify the molecule C[C@H](Oc1cccc(/C=C2/SC(=S)N(c3ccc(Cl)c(Cl)c3)C2=O)c1)C(=O)[O-] by removing a benzene_ring.,C[C@H](Oc1cccc(/C=C2/SC(=S)N(c3ccc(Cl)c(Cl)c3)C2=O)c1)C(=O)[O-],benzene_ring
+185877,Please remove a halo from the molecule COC(=O)c1ccc(NC(=O)N[C@@H]2CC[C@H]([NH+](C)C)C2)c(F)c1.,COC(=O)c1ccc(NC(=O)N[C@@H]2CC[C@H]([NH+](C)C)C2)c(F)c1,halo
+144020,Remove a halo from the molecule O=C([O-])c1c(-c2ccc(Cl)cc2)noc1CO[C@@H]1CCCCO1.,O=C([O-])c1c(-c2ccc(Cl)cc2)noc1CO[C@@H]1CCCCO1,halo
+33001,Please remove a halo from the molecule CC1=NN(C(=O)COc2ccc(C(C)(C)c3ccccc3)cc2)[C@@](O)(C(F)(F)F)C1.,CC1=NN(C(=O)COc2ccc(C(C)(C)c3ccccc3)cc2)[C@@](O)(C(F)(F)F)C1,halo
+148846,Remove a benzene_ring from the molecule CCc1nc(CS(=O)(=O)Cc2ccc(F)c(Br)c2)cs1.,CCc1nc(CS(=O)(=O)Cc2ccc(F)c(Br)c2)cs1,benzene_ring
+156129,Remove a hydroxyl from the molecule CCn1ncc(C[NH+]2CCC3(CC2)c2ccccc2[C@@H]([NH+](C)C)[C@@H]3O)c1C.,CCn1ncc(C[NH+]2CCC3(CC2)c2ccccc2[C@@H]([NH+](C)C)[C@@H]3O)c1C,hydroxyl
+164718,Modify the molecule COC(=O)CN[C@H]1CC[C@H]([NH3+])C1 by removing a amine.,COC(=O)CN[C@H]1CC[C@H]([NH3+])C1,amine
+120380,Remove a amine from the molecule C[C@H](OC(=O)c1nccnc1N)c1nc(C(C)(C)C)no1.,C[C@H](OC(=O)c1nccnc1N)c1nc(C(C)(C)C)no1,amine
+6098,Modify the molecule COc1ccc2cc(C(=O)N(C)c3ccc(OC)nc3)[nH]c2c1 by removing a amide.,COc1ccc2cc(C(=O)N(C)c3ccc(OC)nc3)[nH]c2c1,amide
+64711,Modify the molecule N#Cc1ccc(N(C(=O)c2cc(=O)c3ccccc3o2)C2CC2)cc1 by removing a benzene_ring.,N#Cc1ccc(N(C(=O)c2cc(=O)c3ccccc3o2)C2CC2)cc1,benzene_ring
+188397,Remove a benzene_ring from the molecule O=C(NC[C@@H](O)c1ccccc1Cl)c1ccc(OC(F)F)cc1.,O=C(NC[C@@H](O)c1ccccc1Cl)c1ccc(OC(F)F)cc1,benzene_ring
+20060,Remove a nitrile from the molecule N#C[C@]1(C2(O)CC[NH2+]CC2)CCc2ccccc2C1.,N#C[C@]1(C2(O)CC[NH2+]CC2)CCc2ccccc2C1,nitrile
+238699,Modify the molecule CCOC(=O)c1ccc(NC(=S)NC(=O)C2CC2)cc1 by removing a amide.,CCOC(=O)c1ccc(NC(=S)NC(=O)C2CC2)cc1,amide
+181679,Remove a amine from the molecule O=C(c1ccccc1NS(=O)(=O)/C=C/c1ccccc1)N1CCCCC1.,O=C(c1ccccc1NS(=O)(=O)/C=C/c1ccccc1)N1CCCCC1,amine
+34522,Please remove a amide from the molecule CC(C)(C)Oc1cc(C(=O)N2CCC(CO)CC2)ccn1.,CC(C)(C)Oc1cc(C(=O)N2CCC(CO)CC2)ccn1,amide
+16662,Modify the molecule CN(CC(F)F)C(=O)CCc1ccc(F)cc1F by removing a amide.,CN(CC(F)F)C(=O)CCc1ccc(F)cc1F,amide
+72047,Remove a halo from the molecule COc1ccc(-c2nn3c(SCC(=O)c4ccc(Cl)cc4)nnc3nc2[O-])cc1.,COc1ccc(-c2nn3c(SCC(=O)c4ccc(Cl)cc4)nnc3nc2[O-])cc1,halo
+123669,Remove a amine from the molecule CCN[C@@]1(C(=O)OC)CC[C@@H](OC(C)(C)C)C1.,CCN[C@@]1(C(=O)OC)CC[C@@H](OC(C)(C)C)C1,amine
+245999,Please remove a benzene_ring from the molecule C[C@@H]([C@H](C)C[NH2+]C(C)(C)C)N(C)Cc1ccccc1.,C[C@@H]([C@H](C)C[NH2+]C(C)(C)C)N(C)Cc1ccccc1,benzene_ring
+49945,Remove a halo from the molecule C[C@@H](Oc1ccc(Cl)cc1)C(=O)Nc1ccc(NC(=O)c2ccccc2)cc1.,C[C@@H](Oc1ccc(Cl)cc1)C(=O)Nc1ccc(NC(=O)c2ccccc2)cc1,halo
+182163,Remove a benzene_ring from the molecule CCOc1ccc(N2CCn3c2nn(CC(=O)N2CCCCCC2)c(=O)c3=O)cc1.,CCOc1ccc(N2CCn3c2nn(CC(=O)N2CCCCCC2)c(=O)c3=O)cc1,benzene_ring
+136059,Please remove a amide from the molecule C[C@H]1CCC[NH+](C(C)(C)CNC(=O)/C=C/c2ccc3c(c2)OCO3)C1.,C[C@H]1CCC[NH+](C(C)(C)CNC(=O)/C=C/c2ccc3c(c2)OCO3)C1,amide
+136893,Modify the molecule CCn1/c(=N/C(=O)CN2C(=O)CCC2=O)sc2cc(F)cc(F)c21 by removing a halo.,CCn1/c(=N/C(=O)CN2C(=O)CCC2=O)sc2cc(F)cc(F)c21,halo
+97434,Remove a halo from the molecule CN1CCN(C(=O)CCCN2C(=O)/C(=C/c3cccc(Br)c3)SC2=S)CC1.,CN1CCN(C(=O)CCCN2C(=O)/C(=C/c3cccc(Br)c3)SC2=S)CC1,halo
+101316,Modify the molecule CO/N=C(/C(=O)Nc1cc(C(N)=O)c(F)cc1F)c1ccco1 by removing a halo.,CO/N=C(/C(=O)Nc1cc(C(N)=O)c(F)cc1F)c1ccco1,halo
+73639,Remove a benzene_ring from the molecule CCOc1ccc(/N=C2/C(=O)N(CN3CCOCC3)c3ccccc32)cc1.,CCOc1ccc(/N=C2/C(=O)N(CN3CCOCC3)c3ccccc32)cc1,benzene_ring
+48440,Modify the molecule NC1=NC(=O)[C@H](c2ccc(Br)cc2)C([O-])=N1 by removing a benzene_ring.,NC1=NC(=O)[C@H](c2ccc(Br)cc2)C([O-])=N1,benzene_ring
+242407,Please remove a amide from the molecule COc1ccccc1NC(=O)c1ccc(NC(=O)C[NH+]2CCC[C@H]2c2ccc3c(c2)OCCO3)cc1.,COc1ccccc1NC(=O)c1ccc(NC(=O)C[NH+]2CCC[C@H]2c2ccc3c(c2)OCCO3)cc1,amide
+96234,Please remove a benzene_ring from the molecule Cc1ccc(NC(=O)C(C)C)cc1NCC(=O)N1C[C@@H](C)O[C@H](C)C1.,Cc1ccc(NC(=O)C(C)C)cc1NCC(=O)N1C[C@@H](C)O[C@H](C)C1,benzene_ring
+131159,Modify the molecule C[C@H]1CCc2c(C(=O)N3CCN(c4cc[nH+]cc4)CC3)csc2C1 by removing a amide.,C[C@H]1CCc2c(C(=O)N3CCN(c4cc[nH+]cc4)CC3)csc2C1,amide
+63231,Modify the molecule CC(=O)Nn1c(C)cc(CN2CCN(c3[nH+]cccc3C)CC2)c1C by removing a amide.,CC(=O)Nn1c(C)cc(CN2CCN(c3[nH+]cccc3C)CC2)c1C,amide
+131127,Remove a benzene_ring from the molecule Cc1ccc(O)c(C(=O)NCc2ccc(-c3csc(C)n3)s2)c1.,Cc1ccc(O)c(C(=O)NCc2ccc(-c3csc(C)n3)s2)c1,benzene_ring
+21627,Modify the molecule O=C(NC[C@]1(O)CCOc2ccccc21)C1CCC1 by removing a hydroxyl.,O=C(NC[C@]1(O)CCOc2ccccc21)C1CCC1,hydroxyl
+199758,Modify the molecule CCCn1c(C)nn(CN2CCO[C@@H](c3ccccc3Cl)C2)c1=S by removing a halo.,CCCn1c(C)nn(CN2CCO[C@@H](c3ccccc3Cl)C2)c1=S,halo
+176082,Modify the molecule C[C@H](CO)N(C)C(=O)CCn1cnc2sc3c(c2c1=O)CCCC3 by removing a hydroxyl.,C[C@H](CO)N(C)C(=O)CCn1cnc2sc3c(c2c1=O)CCCC3,hydroxyl
+32457,Modify the molecule CCc1cccc(NC(=O)c2cn(-c3ccc(-c4noc(C5CC5)n4)cc3)nc2C)c1 by removing a benzene_ring.,CCc1cccc(NC(=O)c2cn(-c3ccc(-c4noc(C5CC5)n4)cc3)nc2C)c1,benzene_ring
+169324,Please remove a benzene_ring from the molecule COc1ccc(-c2csc(Nc3ncccc3C)n2)cc1OC.,COc1ccc(-c2csc(Nc3ncccc3C)n2)cc1OC,benzene_ring
+93493,Please remove a amine from the molecule CC[C@@H](C)CN(CC)c1ncnc2ccc(N)cc12.,CC[C@@H](C)CN(CC)c1ncnc2ccc(N)cc12,amine
+187404,Please remove a benzene_ring from the molecule CCc1cnc(CCNC(=O)Nc2cc(OC)ccc2F)s1.,CCc1cnc(CCNC(=O)Nc2cc(OC)ccc2F)s1,benzene_ring
+200840,Modify the molecule CCC[C@H]1C[C@]1(O)c1cscn1 by removing a hydroxyl.,CCC[C@H]1C[C@]1(O)c1cscn1,hydroxyl
+79696,Remove a amide from the molecule CC(=O)Nc1ccc(-c2nc(Cn3cccn3)c(C)o2)cc1.,CC(=O)Nc1ccc(-c2nc(Cn3cccn3)c(C)o2)cc1,amide
+227504,Modify the molecule Cc1cccn2c(=O)c(C(=O)NC[C@@H](C)CN3CCOCC3)cnc12 by removing a amide.,Cc1cccn2c(=O)c(C(=O)NC[C@@H](C)CN3CCOCC3)cnc12,amide
+48366,Please remove a halo from the molecule Cc1cc(C)n2c(CN(CC(F)F)C3CC3)cnc2n1.,Cc1cc(C)n2c(CN(CC(F)F)C3CC3)cnc2n1,halo
+104181,Modify the molecule CCOC(=O)C1=C(N)OC2=C(C(=O)CC(C)(C)C2)[C@H]1c1c(OCC)ccc2ccccc12 by removing a amine.,CCOC(=O)C1=C(N)OC2=C(C(=O)CC(C)(C)C2)[C@H]1c1c(OCC)ccc2ccccc12,amine
+189984,Please remove a benzene_ring from the molecule COc1ccc([C@@H]2CC(=O)C(/C=N/C3Cc4ccccc4C3)=C([O-])C2)cc1OC.,COc1ccc([C@@H]2CC(=O)C(/C=N/C3Cc4ccccc4C3)=C([O-])C2)cc1OC,benzene_ring
+141677,Modify the molecule C[C@H]1CC(C(=O)N[C@@H]2CCc3c2ccc(Cl)c3Cl)C[C@@H](C)O1 by removing a halo.,C[C@H]1CC(C(=O)N[C@@H]2CCc3c2ccc(Cl)c3Cl)C[C@@H](C)O1,halo
+66610,Remove a amide from the molecule CCOc1ccccc1CN1CCN(c2cccc3c2C(=O)N(CC2(O)CCCCC2)C3=O)CC1.,CCOc1ccccc1CN1CCN(c2cccc3c2C(=O)N(CC2(O)CCCCC2)C3=O)CC1,amide
+8405,Remove a benzene_ring from the molecule COc1ccc(CC(=O)N2CCN(S(=O)(=O)c3ccc4c(c3)sc(=O)n4C)CC2)cc1OC.,COc1ccc(CC(=O)N2CCN(S(=O)(=O)c3ccc4c(c3)sc(=O)n4C)CC2)cc1OC,benzene_ring
+115858,Remove a benzene_ring from the molecule CCNC(=O)NNC(=O)[C@H]1CCC(=O)N(c2ccc(C)c(C)c2)C1.,CCNC(=O)NNC(=O)[C@H]1CCC(=O)N(c2ccc(C)c(C)c2)C1,benzene_ring
+118526,Please remove a halo from the molecule Cc1nnc(C[NH+](Cc2c(F)cccc2N2CCCC2)C(C)(C)C)o1.,Cc1nnc(C[NH+](Cc2c(F)cccc2N2CCCC2)C(C)(C)C)o1,halo
+42730,Please remove a benzene_ring from the molecule COc1ccc(-c2n[nH]c(CC(C)C)c2NC(=O)c2cccc(Cl)c2)cc1OC.,COc1ccc(-c2n[nH]c(CC(C)C)c2NC(=O)c2cccc(Cl)c2)cc1OC,benzene_ring
+46195,Remove a amide from the molecule O=C(Nc1ccccc1OCC(F)(F)F)C(=O)N[C@@H]1CCc2ccccc21.,O=C(Nc1ccccc1OCC(F)(F)F)C(=O)N[C@@H]1CCc2ccccc21,amide
+110956,Please remove a amide from the molecule C[C@H](NC(=O)C(C)(C)c1ccccc1)c1ccc2c(c1)OCCO2.,C[C@H](NC(=O)C(C)(C)c1ccccc1)c1ccc2c(c1)OCCO2,amide
+226418,Modify the molecule CC(=O)Nc1nnc(-c2cccc(SC(C)C)c2)o1 by removing a amide.,CC(=O)Nc1nnc(-c2cccc(SC(C)C)c2)o1,amide
+115835,Modify the molecule CC[C@H](NC(=O)N[C@H](C)Cc1c(C)nn(C)c1C)C(C)(C)c1ccccc1 by removing a benzene_ring.,CC[C@H](NC(=O)N[C@H](C)Cc1c(C)nn(C)c1C)C(C)(C)c1ccccc1,benzene_ring
+11886,Please remove a amide from the molecule O=C1CC[C@H](COC(=O)[C@@H]2CCCN2C(=O)C23CC4CC(CC(C4)C2)C3)N1.,O=C1CC[C@H](COC(=O)[C@@H]2CCCN2C(=O)C23CC4CC(CC(C4)C2)C3)N1,amide
+180750,Remove a benzene_ring from the molecule Cc1ccc([S@@](=O)Cc2nnc(-c3ccccc3C)o2)c(C)c1.,Cc1ccc([S@@](=O)Cc2nnc(-c3ccccc3C)o2)c(C)c1,benzene_ring
+28490,Remove a nitro from the molecule C=CCN1C(=O)S/C(=C/c2ccccc2[N+](=O)[O-])C1=O.,C=CCN1C(=O)S/C(=C/c2ccccc2[N+](=O)[O-])C1=O,nitro
+55918,Remove a benzene_ring from the molecule COc1ccc(C(C)=O)cc1CC(=O)N[C@H](C)c1cn(C)nc1C.,COc1ccc(C(C)=O)cc1CC(=O)N[C@H](C)c1cn(C)nc1C,benzene_ring
+99980,Modify the molecule Cc1sc(NC(=O)c2ccccc2)c(CN2CCc3ccccc3C2)c1C by removing a amide.,Cc1sc(NC(=O)c2ccccc2)c(CN2CCc3ccccc3C2)c1C,amide
+177221,Please remove a benzene_ring from the molecule COCCC[C@]1(CO)CCCN(S(=O)(=O)c2ccc(C)c(F)c2)C1.,COCCC[C@]1(CO)CCCN(S(=O)(=O)c2ccc(C)c(F)c2)C1,benzene_ring
+238047,Please remove a halo from the molecule O=C1C[C@@H]([NH2+]CCC2=CCCCC2)C(=O)N1c1cccc(Cl)c1Cl.,O=C1C[C@@H]([NH2+]CCC2=CCCCC2)C(=O)N1c1cccc(Cl)c1Cl,halo
+16193,Modify the molecule O=c1ccc(-c2ccc(Br)cc2)nn1Cc1ccc(F)cc1 by removing a halo.,O=c1ccc(-c2ccc(Br)cc2)nn1Cc1ccc(F)cc1,halo
+112110,Remove a amide from the molecule CCCCN1C(=O)[C@@H](C(=O)Nc2nc3ccccc3[nH]2)[C@H](O)c2ccccc21.,CCCCN1C(=O)[C@@H](C(=O)Nc2nc3ccccc3[nH]2)[C@H](O)c2ccccc21,amide
+23491,Modify the molecule COc1cc(N2CC[NH+](C)[C@@]3(CCNC(=O)CC3)C2)nc(OC)n1 by removing a amide.,COc1cc(N2CC[NH+](C)[C@@]3(CCNC(=O)CC3)C2)nc(OC)n1,amide
+92226,Please remove a amine from the molecule CC[C@H](C[NH3+])Nc1nc2ccc(Br)cn2n1.,CC[C@H](C[NH3+])Nc1nc2ccc(Br)cn2n1,amine
+211148,Please remove a amide from the molecule Cc1ccc2c(c1)[C@H](CC(=O)N(C)Cc1ccno1)C(=O)N2.,Cc1ccc2c(c1)[C@H](CC(=O)N(C)Cc1ccno1)C(=O)N2,amide
+93617,Modify the molecule Cc1cccc(-n2c(SCC(=O)N[C@@H]3CCS(=O)(=O)C3)nc3sc(C)c(C)c3c2=O)c1 by removing a benzene_ring.,Cc1cccc(-n2c(SCC(=O)N[C@@H]3CCS(=O)(=O)C3)nc3sc(C)c(C)c3c2=O)c1,benzene_ring
+105300,Modify the molecule COc1cc([C@H](C)NC2CC[NH+](C)CC2)ccc1O by removing a hydroxyl.,COc1cc([C@H](C)NC2CC[NH+](C)CC2)ccc1O,hydroxyl
+165511,Remove a halo from the molecule COC[C@@H](Cl)CN(C)C[C@@H]1COc2ccccc21.,COC[C@@H](Cl)CN(C)C[C@@H]1COc2ccccc21,halo
+187732,Modify the molecule CC(C)C[C@H](Nc1cnn(C)c(=O)c1Cl)C(=O)Nc1nccs1 by removing a amide.,CC(C)C[C@H](Nc1cnn(C)c(=O)c1Cl)C(=O)Nc1nccs1,amide
+196674,Remove a amide from the molecule CC(C)OCC[NH+]1CCC(NC(=O)CN2CCCCC2=O)CC1.,CC(C)OCC[NH+]1CCC(NC(=O)CN2CCCCC2=O)CC1,amide
+211293,Modify the molecule C[NH+](CC(=O)NC(=O)NCc1ccco1)C[C@@H]1COc2ccccc2O1 by removing a amide.,C[NH+](CC(=O)NC(=O)NCc1ccco1)C[C@@H]1COc2ccccc2O1,amide
+5892,Modify the molecule O=C(OCC(=O)N1CCCC1)c1cn(-c2ccccc2)nc1-c1ccc(F)cc1 by removing a halo.,O=C(OCC(=O)N1CCCC1)c1cn(-c2ccccc2)nc1-c1ccc(F)cc1,halo
+22358,Remove a amide from the molecule C[C@H](C(=O)Nc1cccc([N+](=O)[O-])c1)N1C(=O)c2ccccc2C1=O.,C[C@H](C(=O)Nc1cccc([N+](=O)[O-])c1)N1C(=O)c2ccccc2C1=O,amide
+204815,Modify the molecule CCN(C[C@H](C)C#N)C(=O)Cn1cnc2c(cnn2-c2ccccc2)c1=O by removing a benzene_ring.,CCN(C[C@H](C)C#N)C(=O)Cn1cnc2c(cnn2-c2ccccc2)c1=O,benzene_ring
+204493,Modify the molecule Cc1nc(N2CCC(C(=O)NCc3ccccc3Cl)CC2)nc2cc(S(C)(=O)=O)ccc12 by removing a benzene_ring.,Cc1nc(N2CCC(C(=O)NCc3ccccc3Cl)CC2)nc2cc(S(C)(=O)=O)ccc12,benzene_ring
+66546,Remove a amide from the molecule Cc1ccc2nc(NC(=O)CSc3nnc(Cn4c(=O)sc5ccccc54)n3C)sc2c1.,Cc1ccc2nc(NC(=O)CSc3nnc(Cn4c(=O)sc5ccccc54)n3C)sc2c1,amide
+44411,Modify the molecule CN(C)c1ccc(-n2nc3ccc(NC(=O)c4cc([N+](=O)[O-])ccc4Br)cc3n2)cc1 by removing a nitro.,CN(C)c1ccc(-n2nc3ccc(NC(=O)c4cc([N+](=O)[O-])ccc4Br)cc3n2)cc1,nitro
+169801,Remove a amide from the molecule Cc1nc(CN(C)C(=O)c2cnn(-c3nccc(-c4ccco4)n3)c2C)cs1.,Cc1nc(CN(C)C(=O)c2cnn(-c3nccc(-c4ccco4)n3)c2C)cs1,amide
+176723,Remove a benzene_ring from the molecule CC[C@@H](C(=O)Nc1c(C(=O)OC)[nH]c2ccc(C)cc12)c1ccccc1.,CC[C@@H](C(=O)Nc1c(C(=O)OC)[nH]c2ccc(C)cc12)c1ccccc1,benzene_ring
+52384,Remove a benzene_ring from the molecule C=CCN(Cc1cccc(C#N)c1)Cc1c[nH]nc1-c1ccc2c(c1)OCCO2.,C=CCN(Cc1cccc(C#N)c1)Cc1c[nH]nc1-c1ccc2c(c1)OCCO2,benzene_ring
+58145,Please remove a halo from the molecule O=C(NCc1cccc(Cl)c1)C(=O)N[C@H]1CCCCNC1=O.,O=C(NCc1cccc(Cl)c1)C(=O)N[C@H]1CCCCNC1=O,halo
+126141,Remove a amide from the molecule CC[C@](C)(NC(=O)CCOC1CCOCC1)c1nccs1.,CC[C@](C)(NC(=O)CCOC1CCOCC1)c1nccs1,amide
+176148,Modify the molecule Cc1cc(OCC(=O)NNC(=O)[C@H](C)Oc2ccc(Cl)cc2Cl)ccc1Cl by removing a amide.,Cc1cc(OCC(=O)NNC(=O)[C@H](C)Oc2ccc(Cl)cc2Cl)ccc1Cl,amide
+190315,Remove a amide from the molecule O=C(Cc1ccc(-n2cccc2)cc1)NCc1csc(C2CC2)n1.,O=C(Cc1ccc(-n2cccc2)cc1)NCc1csc(C2CC2)n1,amide
+47466,Remove a benzene_ring from the molecule CCOc1cccc2sc(N3CCN(C(=O)/C=C/c4ccccc4Cl)CC3)nc12.,CCOc1cccc2sc(N3CCN(C(=O)/C=C/c4ccccc4Cl)CC3)nc12,benzene_ring
+71649,Modify the molecule C[C@H](CCCO)N[C@H]1C[NH+]2CCC1CC2 by removing a hydroxyl.,C[C@H](CCCO)N[C@H]1C[NH+]2CCC1CC2,hydroxyl
+65169,Please remove a amide from the molecule O=C(NCCCCN1CCOCC1)c1csc2c1CCCC2.,O=C(NCCCCN1CCOCC1)c1csc2c1CCCC2,amide
+49553,Modify the molecule Cn1cc(C(=O)N2CCCCC2)cc(NC(=O)c2cc(=O)c3ccccc3o2)c1=O by removing a amide.,Cn1cc(C(=O)N2CCCCC2)cc(NC(=O)c2cc(=O)c3ccccc3o2)c1=O,amide
+72018,Please remove a amide from the molecule CC(C)[C@@H](O)CNC(=O)C(=O)Nc1ccc2[nH]c(C(F)F)nc2c1.,CC(C)[C@@H](O)CNC(=O)C(=O)Nc1ccc2[nH]c(C(F)F)nc2c1,amide
+84799,Modify the molecule COc1ccccc1[C@H](C)NC(=O)[C@H](C)SCC(C)C by removing a benzene_ring.,COc1ccccc1[C@H](C)NC(=O)[C@H](C)SCC(C)C,benzene_ring
+134402,Please remove a amide from the molecule COc1ccc(/C=N/NC(=O)CC#N)cc1Br.,COc1ccc(/C=N/NC(=O)CC#N)cc1Br,amide
+187285,Remove a benzene_ring from the molecule O=[S@@](CCN1CCCN(Cc2cccs2)CC1)c1ccccc1.,O=[S@@](CCN1CCCN(Cc2cccs2)CC1)c1ccccc1,benzene_ring
+205982,Remove a nitrile from the molecule N#Cc1ccc(/C=C\c2[nH+]ccc3c2[nH]c2ccccc23)cc1.,N#Cc1ccc(/C=C\c2[nH+]ccc3c2[nH]c2ccccc23)cc1,nitrile
+218437,Please remove a amide from the molecule O=C(c1ccccc1)N1C[C@@H]2CC[C@H](C1)N(C(=O)CCc1ccccn1)C2.,O=C(c1ccccc1)N1C[C@@H]2CC[C@H](C1)N(C(=O)CCc1ccccn1)C2,amide
+191046,Please remove a nitrile from the molecule N#CCCN(Cc1ccccn1)Cc1n[nH]c(=O)[nH]1.,N#CCCN(Cc1ccccn1)Cc1n[nH]c(=O)[nH]1,nitrile
+304,Modify the molecule O=C(c1cccs1)N(Cc1ccc(F)cc1)Cc1cc(-c2ccccc2)cn2nnnc12 by removing a amide.,O=C(c1cccs1)N(Cc1ccc(F)cc1)Cc1cc(-c2ccccc2)cn2nnnc12,amide
+117282,Modify the molecule CN(C)c1ccc([C@H](CNC(=O)C(=O)Nc2ccccc2F)N2CCc3ccccc32)cc1 by removing a halo.,CN(C)c1ccc([C@H](CNC(=O)C(=O)Nc2ccccc2F)N2CCc3ccccc32)cc1,halo
+21600,Remove a amide from the molecule O=C([O-])CNC(=O)/C=C/c1cccs1.,O=C([O-])CNC(=O)/C=C/c1cccs1,amide
+210050,Please remove a halo from the molecule C[C@H]1CCC[C@](O)(CNC(=O)Cc2c(F)cccc2F)C1.,C[C@H]1CCC[C@](O)(CNC(=O)Cc2c(F)cccc2F)C1,halo
+162744,Remove a benzene_ring from the molecule C/C(=N\NC(N)=S)c1ccc(O)cc1O.,C/C(=N\NC(N)=S)c1ccc(O)cc1O,benzene_ring
+49951,Remove a amide from the molecule Cc1cc2c(n1-c1ccc(C(=O)NCc3ccccc3)cc1)CCCC2.,Cc1cc2c(n1-c1ccc(C(=O)NCc3ccccc3)cc1)CCCC2,amide
+147902,Modify the molecule C[C@H](C[C@H]1CCC[NH2+]C1)c1ccccc1 by removing a benzene_ring.,C[C@H](C[C@H]1CCC[NH2+]C1)c1ccccc1,benzene_ring
+194241,Remove a nitrile from the molecule N#Cc1csc(C[NH2+][C@H]2CCC[C@@H](OCC(F)(F)F)C2)c1.,N#Cc1csc(C[NH2+][C@H]2CCC[C@@H](OCC(F)(F)F)C2)c1,nitrile
+200930,Modify the molecule CCc1c(C)sc(NC(=S)N2CC[NH+]3CCC[C@H]3C2)c1C(=O)OC by removing a amine.,CCc1c(C)sc(NC(=S)N2CC[NH+]3CCC[C@H]3C2)c1C(=O)OC,amine
+86448,Please remove a halo from the molecule O[C@H]1C[C@@H](c2cc(F)ccc2F)N(Cc2cnc(C3CC3)s2)C1.,O[C@H]1C[C@@H](c2cc(F)ccc2F)N(Cc2cnc(C3CC3)s2)C1,halo
+247401,Remove a hydroxyl from the molecule Cc1csc(C[C@H](O)Cc2nccs2)n1.,Cc1csc(C[C@H](O)Cc2nccs2)n1,hydroxyl
+169721,Remove a benzene_ring from the molecule COc1cccc(CNC(=O)[C@H](C)Sc2nc(C)nc3ccccc23)c1.,COc1cccc(CNC(=O)[C@H](C)Sc2nc(C)nc3ccccc23)c1,benzene_ring
+85029,Remove a amide from the molecule O=C(N[C@H]1C(=O)N/[N+](=C\c2ccc(Br)cc2)[C@H]1c1ccccc1)c1ccc(F)cc1.,O=C(N[C@H]1C(=O)N/[N+](=C\c2ccc(Br)cc2)[C@H]1c1ccccc1)c1ccc(F)cc1,amide
+136361,Please remove a benzene_ring from the molecule CC[C@@H](C)NC(=O)c1cccc(NC(=O)[C@H]2CCCC[C@@H]2C(=O)[O-])c1.,CC[C@@H](C)NC(=O)c1cccc(NC(=O)[C@H]2CCCC[C@@H]2C(=O)[O-])c1,benzene_ring
+43131,Please remove a amide from the molecule O=C(c1ccc(NS(=O)(=O)c2ccccc2)cc1)N1CCc2ccccc2C1.,O=C(c1ccc(NS(=O)(=O)c2ccccc2)cc1)N1CCc2ccccc2C1,amide
+32348,Modify the molecule CC1=C(C)C[C@@H](C(=O)NNC(=O)c2sccc2C)[C@@H](C(=O)[O-])C1 by removing a amide.,CC1=C(C)C[C@@H](C(=O)NNC(=O)c2sccc2C)[C@@H](C(=O)[O-])C1,amide
+246693,Please remove a amide from the molecule Cc1ncc(Cl)c(C(=O)N[C@H]2CC[C@H]([NH+](C)C)C2)n1.,Cc1ncc(Cl)c(C(=O)N[C@H]2CC[C@H]([NH+](C)C)C2)n1,amide
+92630,Please remove a benzene_ring from the molecule O=C(Cc1cccs1)NCCOc1ccc2nnc(-c3ccccc3)n2n1.,O=C(Cc1cccs1)NCCOc1ccc2nnc(-c3ccccc3)n2n1,benzene_ring
+184459,Remove a halo from the molecule CCOC(=O)[C@H](C)Nc1cc(-n2ncc(=O)n(C)c2=O)c(F)cc1F.,CCOC(=O)[C@H](C)Nc1cc(-n2ncc(=O)n(C)c2=O)c(F)cc1F,halo
+101987,Please remove a halo from the molecule O=C(Nc1ccc(NC(=O)c2ccccc2Cl)cc1)c1cccnc1.,O=C(Nc1ccc(NC(=O)c2ccccc2Cl)cc1)c1cccnc1,halo
+29064,Modify the molecule N/C(CCCSc1ccccc1[N+](=O)[O-])=N\O by removing a nitro.,N/C(CCCSc1ccccc1[N+](=O)[O-])=N\O,nitro
+67827,Modify the molecule C[C@@H](NC1=[NH+]CCC1)C(=O)[O-] by removing a amine.,C[C@@H](NC1=[NH+]CCC1)C(=O)[O-],amine
+31805,Please remove a nitro from the molecule COc1cccc(N2C(=O)c3oc4ccccc4c(=O)c3[C@H]2c2cccc([N+](=O)[O-])c2)c1.,COc1cccc(N2C(=O)c3oc4ccccc4c(=O)c3[C@H]2c2cccc([N+](=O)[O-])c2)c1,nitro
+134741,Please remove a amide from the molecule Cc1ccc(S(C)(=O)=O)cc1C(=O)NCCOCC(=O)[O-].,Cc1ccc(S(C)(=O)=O)cc1C(=O)NCCOCC(=O)[O-],amide
+449,Remove a halo from the molecule COc1cc(Cl)c(C)cc1NC(=O)[C@H](C)N1CCN(S(=O)(=O)c2c(C)noc2C)CC1.,COc1cc(Cl)c(C)cc1NC(=O)[C@H](C)N1CCN(S(=O)(=O)c2c(C)noc2C)CC1,halo
+51606,Modify the molecule CCOCCn1c(NN)nc2c1c(=O)n(C)c(=O)n2C by removing a amine.,CCOCCn1c(NN)nc2c1c(=O)n(C)c(=O)n2C,amine
+176348,Please remove a benzene_ring from the molecule O=C(Nc1ccc(Oc2ccc(Br)cc2)cc1)c1cnc2n(c1=O)CCS2.,O=C(Nc1ccc(Oc2ccc(Br)cc2)cc1)c1cnc2n(c1=O)CCS2,benzene_ring
+96892,Modify the molecule COc1ccc(NCc2ccccc2C#N)c(OC)c1 by removing a amine.,COc1ccc(NCc2ccccc2C#N)c(OC)c1,amine
+226716,Modify the molecule COc1cccc(C[NH+]2CCNC(=O)[C@@H]2CC(=O)N2CCNC(=O)C2)c1 by removing a benzene_ring.,COc1cccc(C[NH+]2CCNC(=O)[C@@H]2CC(=O)N2CCNC(=O)C2)c1,benzene_ring
+149521,Remove a amine from the molecule CCn1c([C@@H](C)NC[C@@H](C2CC2)[NH+](C)C)nc2ccccc21.,CCn1c([C@@H](C)NC[C@@H](C2CC2)[NH+](C)C)nc2ccccc21,amine
+247113,Please remove a halo from the molecule Clc1ccc(-c2cnc3cccnc3n2)s1.,Clc1ccc(-c2cnc3cccnc3n2)s1,halo
+111995,Remove a benzene_ring from the molecule O=C(NCCc1ccc(F)cc1)NC[C@@H]1CC[NH+](C2CC2)C1.,O=C(NCCc1ccc(F)cc1)NC[C@@H]1CC[NH+](C2CC2)C1,benzene_ring
+187630,Remove a halo from the molecule NC(=O)c1ccc(CSCCOc2ccc(F)cc2Cl)cc1.,NC(=O)c1ccc(CSCCOc2ccc(F)cc2Cl)cc1,halo
+129018,Please remove a halo from the molecule O=C(CN1CCN(C(=O)c2cccc(Cl)c2Cl)CC1)NCC1CC1.,O=C(CN1CCN(C(=O)c2cccc(Cl)c2Cl)CC1)NCC1CC1,halo
+249414,Modify the molecule O=C(c1ccc(N2C(=O)CCC2=O)cc1)N1CCN(S(=O)(=O)c2ccccc2Cl)CC1 by removing a benzene_ring.,O=C(c1ccc(N2C(=O)CCC2=O)cc1)N1CCN(S(=O)(=O)c2ccccc2Cl)CC1,benzene_ring
+228977,Modify the molecule Cc1ccc(CN2CCO[C@H](c3nccs3)C2)cc1F by removing a benzene_ring.,Cc1ccc(CN2CCO[C@H](c3nccs3)C2)cc1F,benzene_ring
+101667,Please remove a benzene_ring from the molecule C=CCOc1cccc(NC(=O)[C@@H](C)Oc2cccc(C)c2)c1.,C=CCOc1cccc(NC(=O)[C@@H](C)Oc2cccc(C)c2)c1,benzene_ring
+128964,Remove a halo from the molecule C#CCn1/c(=N\C(=O)C2CCN(S(C)(=O)=O)CC2)sc2cc(F)ccc21.,C#CCn1/c(=N\C(=O)C2CCN(S(C)(=O)=O)CC2)sc2cc(F)ccc21,halo
+115492,Remove a amine from the molecule COc1ccc2nc(/N=C(\N)NC(=S)Nc3ccc(Cl)cc3)nc(C)c2c1.,COc1ccc2nc(/N=C(\N)NC(=S)Nc3ccc(Cl)cc3)nc(C)c2c1,amine
+100549,Please remove a amine from the molecule CCCCSc1nc2n(n1)[C@@H](c1sccc1C)C(C(C)=O)=C(C)N2.,CCCCSc1nc2n(n1)[C@@H](c1sccc1C)C(C(C)=O)=C(C)N2,amine
+117440,Modify the molecule Cc1cc(C)cc(C2=CC[NH+](C[C@@H](O)COC[C@@H]3CCCO3)CC2)c1 by removing a benzene_ring.,Cc1cc(C)cc(C2=CC[NH+](C[C@@H](O)COC[C@@H]3CCCO3)CC2)c1,benzene_ring
+162182,Remove a amide from the molecule CN(C(=O)/C=C/c1cccnc1)c1cccc2ncccc12.,CN(C(=O)/C=C/c1cccnc1)c1cccc2ncccc12,amide
+135899,Please remove a benzene_ring from the molecule CCCn1c(SCc2ccccc2)nnc1-c1ccncc1.,CCCn1c(SCc2ccccc2)nnc1-c1ccncc1,benzene_ring
+49130,Modify the molecule CC(=O)N(Cc1ccc(NC(=O)[C@@H]2CCCC[NH+]2C)cc1)C1CC1 by removing a amide.,CC(=O)N(Cc1ccc(NC(=O)[C@@H]2CCCC[NH+]2C)cc1)C1CC1,amide
+199049,Please remove a benzene_ring from the molecule c1ccc(-n2cnc(C[NH+]3CC[C@@]4(CCOC4)C3)n2)cc1.,c1ccc(-n2cnc(C[NH+]3CC[C@@]4(CCOC4)C3)n2)cc1,benzene_ring
+48940,Remove a benzene_ring from the molecule O=C(NCc1ccc(N2CCOCC2)cc1)Nc1cncc2ccccc12.,O=C(NCc1ccc(N2CCOCC2)cc1)Nc1cncc2ccccc12,benzene_ring
+95572,Please remove a benzene_ring from the molecule Cc1ccc(N2/C(=N/C(=O)CCNC(=O)OC(C)(C)C)S[C@H]3CS(=O)(=O)C[C@@H]32)cc1F.,Cc1ccc(N2/C(=N/C(=O)CCNC(=O)OC(C)(C)C)S[C@H]3CS(=O)(=O)C[C@@H]32)cc1F,benzene_ring
+89567,Modify the molecule NN1C(SCC(=O)Nc2ccc(Cl)cc2)=NN[C@@H]1[C@@H]1N=NC2=C1CCC2 by removing a amine.,NN1C(SCC(=O)Nc2ccc(Cl)cc2)=NN[C@@H]1[C@@H]1N=NC2=C1CCC2,amine
+120315,Modify the molecule COC(=O)c1cccc(S(=O)(=O)NCc2csc(C3CC3)n2)c1 by removing a amine.,COC(=O)c1cccc(S(=O)(=O)NCc2csc(C3CC3)n2)c1,amine
+37725,Modify the molecule Cc1ccc([C@@H]([C@@H](C)[NH3+])N2CCN(C)C(=O)C2(C)C)cc1 by removing a benzene_ring.,Cc1ccc([C@@H]([C@@H](C)[NH3+])N2CCN(C)C(=O)C2(C)C)cc1,benzene_ring
+82749,Remove a benzene_ring from the molecule Cn1ncnc1CCNS(=O)(=O)c1cccc(C#N)c1.,Cn1ncnc1CCNS(=O)(=O)c1cccc(C#N)c1,benzene_ring
+83067,Modify the molecule Cc1ccc(C(=O)N[C@H](C#N)c2cccc(Cl)c2Cl)cc1[N-]S(C)(=O)=O by removing a amide.,Cc1ccc(C(=O)N[C@H](C#N)c2cccc(Cl)c2Cl)cc1[N-]S(C)(=O)=O,amide
+143102,Modify the molecule CN(CC(=O)Nc1ccc(Cl)c(Cl)c1)C(=O)CSc1ccc([N+](=O)[O-])cc1 by removing a amide.,CN(CC(=O)Nc1ccc(Cl)c(Cl)c1)C(=O)CSc1ccc([N+](=O)[O-])cc1,amide
+148717,Modify the molecule CN1CC[C@@]2(CCC1=O)CN(C(=O)CCN(C)S(C)(=O)=O)CCN2C by removing a amide.,CN1CC[C@@]2(CCC1=O)CN(C(=O)CCN(C)S(C)(=O)=O)CCN2C,amide
+151059,Please remove a benzene_ring from the molecule Cc1cc(C)c(CNC(=O)N(C)Cc2cn(-c3ccccc3)nc2-c2ccccc2)c(=O)[nH]1.,Cc1cc(C)c(CNC(=O)N(C)Cc2cn(-c3ccccc3)nc2-c2ccccc2)c(=O)[nH]1,benzene_ring
+65505,Modify the molecule C#CCN(C(=O)Cc1cccc(OCC#N)c1)C1CCCC1 by removing a amide.,C#CCN(C(=O)Cc1cccc(OCC#N)c1)C1CCCC1,amide
+175765,Remove a hydroxyl from the molecule O=C(Cn1ccc(=O)c2ccccc21)N[C@@H]1c2ccccc2C[C@@H]1O.,O=C(Cn1ccc(=O)c2ccccc21)N[C@@H]1c2ccccc2C[C@@H]1O,hydroxyl
+8365,Please remove a amide from the molecule CC[NH+]1CCC(CC(=O)N[C@H](C(=O)[O-])c2ccc(F)cc2F)CC1.,CC[NH+]1CCC(CC(=O)N[C@H](C(=O)[O-])c2ccc(F)cc2F)CC1,amide
+6653,Remove a hydroxyl from the molecule C[C@@H](CCO)[NH2+][C@@H]1CCc2[nH]c3ccccc3c2C1.,C[C@@H](CCO)[NH2+][C@@H]1CCc2[nH]c3ccccc3c2C1,hydroxyl
+17786,Please remove a amine from the molecule CNc1cc[nH+]c(CN2CCC[C@H](C)C2)c1.,CNc1cc[nH+]c(CN2CCC[C@H](C)C2)c1,amine
+241378,Modify the molecule C[C@H](NC(=O)C[NH+](C)Cc1nc2ccccc2n1C)c1ccco1 by removing a amide.,C[C@H](NC(=O)C[NH+](C)Cc1nc2ccccc2n1C)c1ccco1,amide
+66876,Modify the molecule COc1ccc(CC(=O)Nc2nonc2-c2ccc(OC(C)C)cc2)cc1 by removing a benzene_ring.,COc1ccc(CC(=O)Nc2nonc2-c2ccc(OC(C)C)cc2)cc1,benzene_ring
+14155,Remove a amide from the molecule CC[C@](C)(NC(=O)c1ccc2ccccc2c1O)C(=O)[O-].,CC[C@](C)(NC(=O)c1ccc2ccccc2c1O)C(=O)[O-],amide
+158593,Remove a amine from the molecule CC[NH+](Cc1nc2c(N)cccc2o1)C[C@@H](C)C#N.,CC[NH+](Cc1nc2c(N)cccc2o1)C[C@@H](C)C#N,amine
+589,Remove a amide from the molecule CC[C@@H](C)N(CC)C(=O)c1ccccc1N.,CC[C@@H](C)N(CC)C(=O)c1ccccc1N,amide
+99115,Remove a halo from the molecule C[C@H](NC(=O)c1cc([N+](=O)[O-])ccc1Cl)c1ccc(F)c(F)c1.,C[C@H](NC(=O)c1cc([N+](=O)[O-])ccc1Cl)c1ccc(F)c(F)c1,halo
+125694,Modify the molecule CSc1ccc(NC(=O)[C@@H](C)n2nc(-c3cc(C)oc3C)cc(N)c2=O)cc1 by removing a amine.,CSc1ccc(NC(=O)[C@@H](C)n2nc(-c3cc(C)oc3C)cc(N)c2=O)cc1,amine
+23931,Please remove a nitrile from the molecule CCOC(=O)c1ccc(CN2CCO[C@H](C#N)C2)o1.,CCOC(=O)c1ccc(CN2CCO[C@H](C#N)C2)o1,nitrile
+135941,Please remove a amide from the molecule CCCc1ccc(C(=O)N2C[C@@H](C[NH+](C)C)[C@@H](CO)C2)cc1.,CCCc1ccc(C(=O)N2C[C@@H](C[NH+](C)C)[C@@H](CO)C2)cc1,amide
+145238,Modify the molecule C[C@H](CC#N)N1CCc2c(F)ccc(F)c2C1 by removing a halo.,C[C@H](CC#N)N1CCc2c(F)ccc(F)c2C1,halo
+52333,Modify the molecule COC[C@@H](C)NC(=O)[C@@H](C)N1C(=O)c2cc(Cl)c(Cl)cc2C1=O by removing a amide.,COC[C@@H](C)NC(=O)[C@@H](C)N1C(=O)c2cc(Cl)c(Cl)cc2C1=O,amide
+172342,Remove a amide from the molecule C[C@H]1OCC[C@H]1C(=O)NCc1ccc(C(=O)NCC[NH+](C)C)cc1.,C[C@H]1OCC[C@H]1C(=O)NCc1ccc(C(=O)NCC[NH+](C)C)cc1,amide
+169274,Please remove a benzene_ring from the molecule CN(C)c1ccccc1NC(=O)NC1CCCC1.,CN(C)c1ccccc1NC(=O)NC1CCCC1,benzene_ring
+81887,Remove a amide from the molecule Cc1ccc([C@@H]2CC(=O)NC3=NC(SCc4ccccc4Cl)=NC(=O)[C@H]32)c(C)c1.,Cc1ccc([C@@H]2CC(=O)NC3=NC(SCc4ccccc4Cl)=NC(=O)[C@H]32)c(C)c1,amide
+111656,Modify the molecule C[C@@H](CCNC(=O)c1cccn1-c1cccnc1)[NH+]1CCCCCC1 by removing a amide.,C[C@@H](CCNC(=O)c1cccn1-c1cccnc1)[NH+]1CCCCCC1,amide
+196786,Remove a amide from the molecule O=C(NCC1(c2ccccc2Cl)CCOCC1)c1cccc(F)c1F.,O=C(NCC1(c2ccccc2Cl)CCOCC1)c1cccc(F)c1F,amide
+170191,Please remove a hydroxyl from the molecule COc1ccc(N(C)C(=O)CCCO)cc1.,COc1ccc(N(C)C(=O)CCCO)cc1,hydroxyl
+228339,Remove a amide from the molecule CCOC(=O)C1(C)CCN(C(=O)c2cc(CC)n[nH]2)CC1.,CCOC(=O)C1(C)CCN(C(=O)c2cc(CC)n[nH]2)CC1,amide
+135167,Modify the molecule COc1ccc(F)cc1NC(=O)[C@@H]1C[C@H]1c1ccc(C)s1 by removing a benzene_ring.,COc1ccc(F)cc1NC(=O)[C@@H]1C[C@H]1c1ccc(C)s1,benzene_ring
+123277,Remove a benzene_ring from the molecule COc1ccc(Cl)cc1C[C@H](O)[C@@H](C)OC.,COc1ccc(Cl)cc1C[C@H](O)[C@@H](C)OC,benzene_ring
+235894,Modify the molecule CS(=O)(=O)N1CCC(C(=O)OCc2ccc(-n3cccn3)cc2)CC1 by removing a benzene_ring.,CS(=O)(=O)N1CCC(C(=O)OCc2ccc(-n3cccn3)cc2)CC1,benzene_ring
+86690,Please remove a hydroxyl from the molecule C[C@@H]1C[C@](CCO)([C@@H](C)[NH3+])CS1.,C[C@@H]1C[C@](CCO)([C@@H](C)[NH3+])CS1,hydroxyl
+227114,Modify the molecule Cc1ccc(NC(=O)CN2CCN(C(=O)CCS(=O)(=O)c3ccc(Cl)cc3)CC2)cc1 by removing a benzene_ring.,Cc1ccc(NC(=O)CN2CCN(C(=O)CCS(=O)(=O)c3ccc(Cl)cc3)CC2)cc1,benzene_ring
+194692,Please remove a amide from the molecule Cc1ccc(-n2ccnc2)c(C(=O)N2CCN(C(=O)[C@H]3C[C@H]3C)CC2)c1.,Cc1ccc(-n2ccnc2)c(C(=O)N2CCN(C(=O)[C@H]3C[C@H]3C)CC2)c1,amide
+64081,Please remove a amide from the molecule CN(C)C(=O)CC1CCN(C(=O)C(C)(C)c2ccccc2F)CC1.,CN(C)C(=O)CC1CCN(C(=O)C(C)(C)c2ccccc2F)CC1,amide
+7899,Please remove a amide from the molecule C[C@@H]1CCC[C@@H](OCC(=O)NNc2ccc(-c3ccccc3)nn2)C1.,C[C@@H]1CCC[C@@H](OCC(=O)NNc2ccc(-c3ccccc3)nn2)C1,amide
+196859,Modify the molecule Cc1cccc(OCCn2c([C@@H]3CC(=O)N(Cc4ccccc4)C3)nc3ccccc32)c1 by removing a benzene_ring.,Cc1cccc(OCCn2c([C@@H]3CC(=O)N(Cc4ccccc4)C3)nc3ccccc32)c1,benzene_ring
+91992,Remove a hydroxyl from the molecule CC(C)CC[C@@H](O)[C@H]1CCO[C@]2(CCSC2)C1.,CC(C)CC[C@@H](O)[C@H]1CCO[C@]2(CCSC2)C1,hydroxyl
+217902,Modify the molecule CC(C)NC(=O)[C@@H]1CC(=O)N(CCC2=c3cc(F)ccc3=[NH+]C2)C1 by removing a amine.,CC(C)NC(=O)[C@@H]1CC(=O)N(CCC2=c3cc(F)ccc3=[NH+]C2)C1,amine
+96111,Modify the molecule C[C@]12CCC(=O)N1[C@H](C(=O)NCc1ccc(Br)cc1F)CS2 by removing a amide.,C[C@]12CCC(=O)N1[C@H](C(=O)NCc1ccc(Br)cc1F)CS2,amide
+64374,Remove a hydroxyl from the molecule COc1ccc(C)cc1[C@@H](O)CN1CCN(c2nccs2)CC1.,COc1ccc(C)cc1[C@@H](O)CN1CCN(c2nccs2)CC1,hydroxyl
+215139,Modify the molecule Cc1cc([NH+](C)C[C@H]2C[C@@H]2C)cc(C(=O)[O-])c1N by removing a amine.,Cc1cc([NH+](C)C[C@H]2C[C@@H]2C)cc(C(=O)[O-])c1N,amine
+98506,Modify the molecule NC(=O)c1ccc(Oc2cccc(C(=O)[O-])c2)nc1 by removing a benzene_ring.,NC(=O)c1ccc(Oc2cccc(C(=O)[O-])c2)nc1,benzene_ring
+207664,Modify the molecule COCC(=O)N1CCC[C@@H](c2nc3c(c(C)[nH+]2)CCCN3Cc2ccc(F)cc2)C1 by removing a halo.,COCC(=O)N1CCC[C@@H](c2nc3c(c(C)[nH+]2)CCCN3Cc2ccc(F)cc2)C1,halo
+31059,Remove a halo from the molecule CC[NH+]1CCN([C@@H](C)C[NH2+][C@@H](C)c2nc3cc(Cl)ccc3n2C)CC1.,CC[NH+]1CCN([C@@H](C)C[NH2+][C@@H](C)c2nc3cc(Cl)ccc3n2C)CC1,halo
+55440,Please remove a amide from the molecule Cc1ccc(C[NH2+][C@H]2CCC(=O)N(C)C2)cc1.,Cc1ccc(C[NH2+][C@H]2CCC(=O)N(C)C2)cc1,amide
+174899,Please remove a amide from the molecule C[C@H](Oc1cccc(Cl)c1)C(=O)N[C@H](C)c1ccc(S(N)(=O)=O)cc1.,C[C@H](Oc1cccc(Cl)c1)C(=O)N[C@H](C)c1ccc(S(N)(=O)=O)cc1,amide
+126338,Please remove a benzene_ring from the molecule CCCCC[C@@H](C)NC(=O)NCc1cccc(F)c1.,CCCCC[C@@H](C)NC(=O)NCc1cccc(F)c1,benzene_ring
+174660,Please remove a amide from the molecule C[C@@H]1CCCC[C@H]1NC(=O)C1CCN(c2ncnc3c2nc2n3CCCCC2)CC1.,C[C@@H]1CCCC[C@H]1NC(=O)C1CCN(c2ncnc3c2nc2n3CCCCC2)CC1,amide
+148843,Modify the molecule CC[C@@H]([NH2+][C@H]1CC(=O)N(CC(F)(F)F)C1)c1cc(C)ccc1OC by removing a amide.,CC[C@@H]([NH2+][C@H]1CC(=O)N(CC(F)(F)F)C1)c1cc(C)ccc1OC,amide
+152444,Remove a hydroxyl from the molecule CC1=C(C(=O)Nc2ccccc2)[C@@H](c2ccc(O)c(O)c2)n2ncnc2N1.,CC1=C(C(=O)Nc2ccccc2)[C@@H](c2ccc(O)c(O)c2)n2ncnc2N1,hydroxyl
+140246,Modify the molecule O=C(NC1CC1)c1ccccc1NC(=O)C1CCOCC1 by removing a amide.,O=C(NC1CC1)c1ccccc1NC(=O)C1CCOCC1,amide
+67874,Modify the molecule Cc1ccsc1C(=O)NNS(=O)(=O)c1c(C)cccc1[N+](=O)[O-] by removing a benzene_ring.,Cc1ccsc1C(=O)NNS(=O)(=O)c1c(C)cccc1[N+](=O)[O-],benzene_ring
+170001,Modify the molecule C[C@@]1(C(=O)NCc2ccc(F)cc2)CCCN(C(=O)Nc2ccc(F)c(Cl)c2)C1 by removing a benzene_ring.,C[C@@]1(C(=O)NCc2ccc(F)cc2)CCCN(C(=O)Nc2ccc(F)c(Cl)c2)C1,benzene_ring
+42611,Remove a amide from the molecule O=C1[C@@H]2CCC[C@@H]2N1C[NH+]1CCC(c2ccccc2)CC1.,O=C1[C@@H]2CCC[C@@H]2N1C[NH+]1CCC(c2ccccc2)CC1,amide
+61487,Modify the molecule O=C(c1ccc2[nH]nnc2c1)N1CCCN(c2ccc(C(F)(F)F)cn2)CC1 by removing a halo.,O=C(c1ccc2[nH]nnc2c1)N1CCCN(c2ccc(C(F)(F)F)cn2)CC1,halo
+48001,Please remove a halo from the molecule C[NH+](Cc1ccc(Br)cc1)[C@H]1CCC[C@@H]1S(C)(=O)=O.,C[NH+](Cc1ccc(Br)cc1)[C@H]1CCC[C@@H]1S(C)(=O)=O,halo
+156782,Please remove a benzene_ring from the molecule CC(C)C[NH+](C)[C@]1(CN)CCN(Cc2ccccc2)C1.,CC(C)C[NH+](C)[C@]1(CN)CCN(Cc2ccccc2)C1,benzene_ring
+145472,Please remove a amide from the molecule Cc1cc(N)cc(C)c1S(=O)(=O)NC[C@@H]1CCC(=O)N1.,Cc1cc(N)cc(C)c1S(=O)(=O)NC[C@@H]1CCC(=O)N1,amide
+62541,Modify the molecule COC(=O)c1sc(N2C(=O)C([O-])=C(C(=O)c3ccccc3)[C@@H]2c2ccccc2OC)nc1C by removing a benzene_ring.,COC(=O)c1sc(N2C(=O)C([O-])=C(C(=O)c3ccccc3)[C@@H]2c2ccccc2OC)nc1C,benzene_ring
+208563,Please remove a benzene_ring from the molecule C[C@@H]([NH2+]Cc1ccc2c(c1)n(C)c(=O)n2C)c1ccccc1.,C[C@@H]([NH2+]Cc1ccc2c(c1)n(C)c(=O)n2C)c1ccccc1,benzene_ring
+53325,Remove a amide from the molecule CC(C)(C)c1noc(CCCC(=O)N[C@@H]2CC[NH+]3CCCC[C@H]23)n1.,CC(C)(C)c1noc(CCCC(=O)N[C@@H]2CC[NH+]3CCCC[C@H]23)n1,amide
+23528,Remove a amine from the molecule Cc1cc(C)c2c(=O)cc(CS[C@@H]3NN[C@@H](c4ccco4)[NH+]3C)[nH]c2c1.,Cc1cc(C)c2c(=O)cc(CS[C@@H]3NN[C@@H](c4ccco4)[NH+]3C)[nH]c2c1,amine
+122894,Remove a amide from the molecule O=C(NCCn1c(=O)c(=O)[nH]c2ccccc21)[C@H]1CCCN(c2ncccn2)C1.,O=C(NCCn1c(=O)c(=O)[nH]c2ccccc21)[C@H]1CCCN(c2ncccn2)C1,amide
+244141,Modify the molecule CC(C)(C)Oc1ccc(O)c([C@H]2CCC[NH2+]2)c1 by removing a benzene_ring.,CC(C)(C)Oc1ccc(O)c([C@H]2CCC[NH2+]2)c1,benzene_ring
+144449,Please remove a amide from the molecule Cc1cc(C)n([C@@H](C)C(=O)N2CCc3c([nH+]cn3C3CC3)C2)n1.,Cc1cc(C)n([C@@H](C)C(=O)N2CCc3c([nH+]cn3C3CC3)C2)n1,amide
+167379,Remove a halo from the molecule C[C@H]1C[C@@H](C)CN(C(=O)CN2CCN(C(=O)CC(F)(F)F)CC2)C1.,C[C@H]1C[C@@H](C)CN(C(=O)CN2CCN(C(=O)CC(F)(F)F)CC2)C1,halo
+35867,Modify the molecule O=C(NCCN1CCN(C(=O)c2cccc([N+](=O)[O-])c2)CC1)c1ccc(F)cc1 by removing a benzene_ring.,O=C(NCCN1CCN(C(=O)c2cccc([N+](=O)[O-])c2)CC1)c1ccc(F)cc1,benzene_ring
+137643,Modify the molecule C[C@H](O)CN(C)C(=O)N[C@@H]1C=CCCC1 by removing a hydroxyl.,C[C@H](O)CN(C)C(=O)N[C@@H]1C=CCCC1,hydroxyl
+56159,Remove a halo from the molecule C=CCN(CC=C)C(=O)[C@@H](C)NC(=O)c1ccc(Cl)cc1Cl.,C=CCN(CC=C)C(=O)[C@@H](C)NC(=O)c1ccc(Cl)cc1Cl,halo
+139797,Modify the molecule C[C@H]1C[C@H](C)CCN1C(=O)C[C@H](O)c1ccc(Cl)cc1 by removing a benzene_ring.,C[C@H]1C[C@H](C)CCN1C(=O)C[C@H](O)c1ccc(Cl)cc1,benzene_ring
+198771,Remove a amide from the molecule CCNC(=O)C1CN(C(=O)C(=O)Nc2cccc(C[NH+]3CCCCC3)c2)C1.,CCNC(=O)C1CN(C(=O)C(=O)Nc2cccc(C[NH+]3CCCCC3)c2)C1,amide
+151765,Modify the molecule CCn1c([C@@H]2CCC[NH2+]C2)nn(C/C=C/c2ccccc2)c1=O by removing a benzene_ring.,CCn1c([C@@H]2CCC[NH2+]C2)nn(C/C=C/c2ccccc2)c1=O,benzene_ring
+88691,Please remove a benzene_ring from the molecule COc1cc(F)cc(CNC(=O)c2sccc2Br)c1.,COc1cc(F)cc(CNC(=O)c2sccc2Br)c1,benzene_ring
+132109,Modify the molecule C/C=C/c1cnc(-c2cccnc2)nc1C1CCN(C(=O)[C@H](C)Oc2ccccc2)CC1 by removing a benzene_ring.,C/C=C/c1cnc(-c2cccnc2)nc1C1CCN(C(=O)[C@H](C)Oc2ccccc2)CC1,benzene_ring
+3134,Remove a halo from the molecule COc1ccc(F)cc1C(=O)Nc1cc(F)ccc1OCC(F)(F)F.,COc1ccc(F)cc1C(=O)Nc1cc(F)ccc1OCC(F)(F)F,halo
+77681,Modify the molecule CCCN1CCN(C(=O)c2ccn(C)n2)C[C@@H](Cc2ccc(-c3ccccc3)cc2)C1=O by removing a amide.,CCCN1CCN(C(=O)c2ccn(C)n2)C[C@@H](Cc2ccc(-c3ccccc3)cc2)C1=O,amide
+184622,Remove a amine from the molecule CC(=O)NCc1ccc(S(=O)(=O)N/N=C/c2cccc([N+](=O)[O-])c2)cc1.,CC(=O)NCc1ccc(S(=O)(=O)N/N=C/c2cccc([N+](=O)[O-])c2)cc1,amine
+64604,Please remove a nitrile from the molecule CN[C@](C#N)(CSC[C@@H](C)CO)C1CC1.,CN[C@](C#N)(CSC[C@@H](C)CO)C1CC1,nitrile
+120959,Please remove a halo from the molecule CCOCC(=O)NNC(=O)c1sc2cccc(F)c2c1COC.,CCOCC(=O)NNC(=O)c1sc2cccc(F)c2c1COC,halo
+59252,Modify the molecule Cn1cccc1[C@@H](CNC(=O)NCCc1ccccc1)[NH+]1CCCCCC1 by removing a benzene_ring.,Cn1cccc1[C@@H](CNC(=O)NCCc1ccccc1)[NH+]1CCCCCC1,benzene_ring
+96346,Remove a halo from the molecule Cc1cc(CNc2ccc(C(=O)[O-])c(F)c2F)sc1C.,Cc1cc(CNc2ccc(C(=O)[O-])c(F)c2F)sc1C,halo
+186660,Please remove a halo from the molecule O=C([C@H]1Cc2ccccc2O1)N(Cc1cccnc1)c1ccc(Cl)cc1.,O=C([C@H]1Cc2ccccc2O1)N(Cc1cccnc1)c1ccc(Cl)cc1,halo
+169430,Please remove a amide from the molecule C[C@@H](NC(=O)Cn1nnc(-c2ccsc2)n1)c1ccco1.,C[C@@H](NC(=O)Cn1nnc(-c2ccsc2)n1)c1ccco1,amide
+52500,Modify the molecule COC(=O)NCC(=O)Nc1nc(-c2ccc3ccccc3c2)cs1 by removing a amide.,COC(=O)NCC(=O)Nc1nc(-c2ccc3ccccc3c2)cs1,amide
+30950,Remove a benzene_ring from the molecule Cc1ccc(-c2csc(NC(=O)CCN3C(=O)[C@@H]4CC[C@](C)(C3=O)C4(C)C)n2)cc1.,Cc1ccc(-c2csc(NC(=O)CCN3C(=O)[C@@H]4CC[C@](C)(C3=O)C4(C)C)n2)cc1,benzene_ring
+167719,Remove a benzene_ring from the molecule CCOC(=O)c1ccc(N2C(=O)[C@@H]3CC4=c5ccccc5=[NH+][C@H]4[C@@H](c4cccc(OC)c4)N3C2=O)cc1.,CCOC(=O)c1ccc(N2C(=O)[C@@H]3CC4=c5ccccc5=[NH+][C@H]4[C@@H](c4cccc(OC)c4)N3C2=O)cc1,benzene_ring
+56486,Please remove a amide from the molecule O=C(Cn1cnc2nc3c(cc2c1=O)CCCC3)NCCC[NH+]1CCc2ccccc2C1.,O=C(Cn1cnc2nc3c(cc2c1=O)CCCC3)NCCC[NH+]1CCc2ccccc2C1,amide
+64276,Modify the molecule CCOC(=O)C[C@@H](NC(=O)c1ccc[n+]([O-])c1)c1ccc(F)cc1 by removing a amide.,CCOC(=O)C[C@@H](NC(=O)c1ccc[n+]([O-])c1)c1ccc(F)cc1,amide
+121276,Please remove a benzene_ring from the molecule Cc1n[nH]c(-c2cccc(CNC(=O)[C@H](C)Cc3cccc(Cl)c3)c2)n1.,Cc1n[nH]c(-c2cccc(CNC(=O)[C@H](C)Cc3cccc(Cl)c3)c2)n1,benzene_ring
+95607,Please remove a amide from the molecule Cc1ccccc1[C@]1(CC(=O)N(C)[C@H](C)c2nccs2)CC(=O)N(Cc2cccnc2)C1=O.,Cc1ccccc1[C@]1(CC(=O)N(C)[C@H](C)c2nccs2)CC(=O)N(Cc2cccnc2)C1=O,amide
+19989,Please remove a benzene_ring from the molecule Cn1cc(S(=O)(=O)[N-]c2c(F)cc(Cl)cc2F)cn1.,Cn1cc(S(=O)(=O)[N-]c2c(F)cc(Cl)cc2F)cn1,benzene_ring
+90586,Modify the molecule COc1ccc(-c2ocnc2C(=O)NCCCn2ccnc2)cc1 by removing a benzene_ring.,COc1ccc(-c2ocnc2C(=O)NCCCn2ccnc2)cc1,benzene_ring
+238954,Modify the molecule CCOc1ccc(NC(=O)[C@@H](CC(C)C)N2Cc3ccccc3C2=O)cc1 by removing a amide.,CCOc1ccc(NC(=O)[C@@H](CC(C)C)N2Cc3ccccc3C2=O)cc1,amide
+222710,Remove a halo from the molecule Cc1nc(Cc2ccc(F)cc2)sc1C(=O)NNC(=O)C[NH+](C)C.,Cc1nc(Cc2ccc(F)cc2)sc1C(=O)NNC(=O)C[NH+](C)C,halo
+247765,Please remove a benzene_ring from the molecule CCN(CC)C(=O)Nc1ccc([C@H](C)NC(=O)C2CC=CC2)cc1.,CCN(CC)C(=O)Nc1ccc([C@H](C)NC(=O)C2CC=CC2)cc1,benzene_ring
+155198,Modify the molecule CC(=O)N1CCC[C@@H](c2cc(CCO)n(C)n2)C1 by removing a amide.,CC(=O)N1CCC[C@@H](c2cc(CCO)n(C)n2)C1,amide
+1992,Remove a halo from the molecule COc1ncnc2c1nc([C@@H](C)Cl)n2[C@H](C)C(N)=O.,COc1ncnc2c1nc([C@@H](C)Cl)n2[C@H](C)C(N)=O,halo
+122666,Remove a amide from the molecule CC(=O)N1CCc2cc(NC(=O)c3ccccc3Cc3ccccc3)ccc21.,CC(=O)N1CCc2cc(NC(=O)c3ccccc3Cc3ccccc3)ccc21,amide
+140513,Modify the molecule Cc1cccc(NC(=O)c2cnc3n(c2=O)CCS3)c1 by removing a benzene_ring.,Cc1cccc(NC(=O)c2cnc3n(c2=O)CCS3)c1,benzene_ring
+159427,Modify the molecule Cc1ccc(C[NH+](C)Cc2c([O-])[nH+]nn2-c2ccccc2)s1 by removing a benzene_ring.,Cc1ccc(C[NH+](C)Cc2c([O-])[nH+]nn2-c2ccccc2)s1,benzene_ring
+16702,Modify the molecule Cc1ccc(F)cc1S(=O)(=O)N1CCc2c(c(COCc3ccc(F)cc3Cl)nn2C)C1 by removing a benzene_ring.,Cc1ccc(F)cc1S(=O)(=O)N1CCc2c(c(COCc3ccc(F)cc3Cl)nn2C)C1,benzene_ring
+200632,Modify the molecule Cn1c(C[C@H](O)Cc2ccccc2F)nc2ccccc21 by removing a hydroxyl.,Cn1c(C[C@H](O)Cc2ccccc2F)nc2ccccc21,hydroxyl
+37496,Modify the molecule Cc1ccc(C(=O)CCC(=O)Nc2ccc(F)c(C(=O)N(C)C)c2)cc1C by removing a amide.,Cc1ccc(C(=O)CCC(=O)Nc2ccc(F)c(C(=O)N(C)C)c2)cc1C,amide
+183937,Please remove a halo from the molecule Fc1ccc(C(Br)c2ccc(F)cc2)cc1.,Fc1ccc(C(Br)c2ccc(F)cc2)cc1,halo
+54550,Modify the molecule CC[C@@H]1c2ccsc2CCN1C(=O)Cn1ccc(=O)c2sccc21 by removing a amide.,CC[C@@H]1c2ccsc2CCN1C(=O)Cn1ccc(=O)c2sccc21,amide
+7447,Modify the molecule O=C(c1cncs1)N1CCC(n2c(CCc3ccccc3)nc3cccnc32)CC1 by removing a benzene_ring.,O=C(c1cncs1)N1CCC(n2c(CCc3ccccc3)nc3cccnc32)CC1,benzene_ring
+203908,Please remove a amide from the molecule CCn1c(N2CCC[C@H](C(=O)NCc3ccco3)C2)cc(=O)n(C)c1=O.,CCn1c(N2CCC[C@H](C(=O)NCc3ccco3)C2)cc(=O)n(C)c1=O,amide
+90181,Remove a benzene_ring from the molecule Cc1nccn1-c1ccc(CNC(=O)[C@@H]2CNC(=O)N2)cc1F.,Cc1nccn1-c1ccc(CNC(=O)[C@@H]2CNC(=O)N2)cc1F,benzene_ring
+33755,Modify the molecule CCc1nc(CC(=O)N(C)Cc2ncnn2C)cs1 by removing a amide.,CCc1nc(CC(=O)N(C)Cc2ncnn2C)cs1,amide
+209513,Please remove a nitrile from the molecule N#Cc1ccc(S(=O)(=O)N[C@H](CN2CCOCC2)c2ccccc2)cc1.,N#Cc1ccc(S(=O)(=O)N[C@H](CN2CCOCC2)c2ccccc2)cc1,nitrile
+10301,Remove a halo from the molecule O=C(CSc1nc(-c2ccc(Cl)cc2)cs1)Nc1cccc2nsnc12.,O=C(CSc1nc(-c2ccc(Cl)cc2)cs1)Nc1cccc2nsnc12,halo
+184009,Modify the molecule CON(C)C(=O)CN1CCN(Cc2csc(-c3ccccc3)n2)CC1 by removing a benzene_ring.,CON(C)C(=O)CN1CCN(Cc2csc(-c3ccccc3)n2)CC1,benzene_ring
+8933,Remove a amine from the molecule COCCNC(=O)[C@H](C)OC(=O)c1cc(C)ccc1N.,COCCNC(=O)[C@H](C)OC(=O)c1cc(C)ccc1N,amine
+155210,Modify the molecule C[C@H](NC(=O)/C=C/c1ccc(S(=O)(=O)N2CCOCC2)cc1)c1ccc2ccccc2c1 by removing a benzene_ring.,C[C@H](NC(=O)/C=C/c1ccc(S(=O)(=O)N2CCOCC2)cc1)c1ccc2ccccc2c1,benzene_ring
+107258,Modify the molecule CC(C)CNS(=O)(=O)c1ccc2c(c1)OCCO2 by removing a amine.,CC(C)CNS(=O)(=O)c1ccc2c(c1)OCCO2,amine
+172785,Modify the molecule Cn1c(=O)n(C)c2cc(NC(=O)CCc3nc4ccccc4s3)ccc21 by removing a amide.,Cn1c(=O)n(C)c2cc(NC(=O)CCc3nc4ccccc4s3)ccc21,amide
+215961,Please remove a halo from the molecule Cc1ccc(-[n+]2noc([O-])c2C[NH2+]Cc2ccc(F)cc2)cc1.,Cc1ccc(-[n+]2noc([O-])c2C[NH2+]Cc2ccc(F)cc2)cc1,halo
+3033,Remove a amide from the molecule COC(=O)[C@@H]1[C@H](CBr)N1N1C(=O)c2ccccc2C1=O.,COC(=O)[C@@H]1[C@H](CBr)N1N1C(=O)c2ccccc2C1=O,amide
+28868,Please remove a amide from the molecule O=C(Nc1cccc2ncccc12)c1cc(-c2ccco2)n([C@H]2CCS(=O)(=O)C2)n1.,O=C(Nc1cccc2ncccc12)c1cc(-c2ccco2)n([C@H]2CCS(=O)(=O)C2)n1,amide
+209521,Modify the molecule COc1cccc(COc2ccc(Br)cc2)c1 by removing a halo.,COc1cccc(COc2ccc(Br)cc2)c1,halo
+249373,Please remove a halo from the molecule Cc1nnc(SCCC(=O)Nc2cccc(F)c2)s1.,Cc1nnc(SCCC(=O)Nc2cccc(F)c2)s1,halo
+248038,Please remove a benzene_ring from the molecule N#Cc1cccc(CNC(=O)Nc2ccc3c4c(cccc24)CC3)c1.,N#Cc1cccc(CNC(=O)Nc2ccc3c4c(cccc24)CC3)c1,benzene_ring
+78141,Please remove a halo from the molecule O=C(CC1C[C@@H]2CC[C@H](C1)[NH2+]2)NCCc1ccc(Cl)cc1.,O=C(CC1C[C@@H]2CC[C@H](C1)[NH2+]2)NCCc1ccc(Cl)cc1,halo
+202113,Modify the molecule C[C@@H](NC(=O)C1CCN(c2ccc(N3CCCC3)nn2)CC1)c1ccccc1 by removing a amide.,C[C@@H](NC(=O)C1CCN(c2ccc(N3CCCC3)nn2)CC1)c1ccccc1,amide
+103779,Modify the molecule C[C@@H](CCCCl)[NH2+]CCC(C)(C)C by removing a halo.,C[C@@H](CCCCl)[NH2+]CCC(C)(C)C,halo
+18326,Modify the molecule C[C@@H]1CN(C(=O)N[C@@H]2CCS(=O)(=O)C2)C[C@H](c2ccc(F)cc2)O1 by removing a halo.,C[C@@H]1CN(C(=O)N[C@@H]2CCS(=O)(=O)C2)C[C@H](c2ccc(F)cc2)O1,halo
+159687,Remove a amide from the molecule CCOC(=O)Nn1c(C)c(C(N)=O)c(C(=O)OC)c1C.,CCOC(=O)Nn1c(C)c(C(N)=O)c(C(=O)OC)c1C,amide
+229462,Remove a benzene_ring from the molecule C[C@@H](Cc1nnc(NC(=O)C2CCN(C(=O)[C@H]3CC(=O)N(C(C)(C)C)C3)CC2)s1)c1ccccc1.,C[C@@H](Cc1nnc(NC(=O)C2CCN(C(=O)[C@H]3CC(=O)N(C(C)(C)C)C3)CC2)s1)c1ccccc1,benzene_ring
+158042,Please remove a amide from the molecule C[C@H](C(=O)NN)[C@H](C)[NH+](C)C[C@@H]1CCCOC1.,C[C@H](C(=O)NN)[C@H](C)[NH+](C)C[C@@H]1CCCOC1,amide
+74227,Please remove a nitrile from the molecule COC(=O)/C(C#N)=C/c1cccc(OC(=O)c2ccc([N+](=O)[O-])cc2Cl)c1.,COC(=O)/C(C#N)=C/c1cccc(OC(=O)c2ccc([N+](=O)[O-])cc2Cl)c1,nitrile
+155361,Modify the molecule O=C(/C=C/c1ccc(Cl)cc1)NC[C@H]1CN2CCCC[C@@H]2CO1 by removing a benzene_ring.,O=C(/C=C/c1ccc(Cl)cc1)NC[C@H]1CN2CCCC[C@@H]2CO1,benzene_ring
+84990,Please remove a benzene_ring from the molecule CS(=O)(=O)[N-]c1cccc(NC(=O)C2(c3cc(-c4ccccc4)on3)CC2)c1.,CS(=O)(=O)[N-]c1cccc(NC(=O)C2(c3cc(-c4ccccc4)on3)CC2)c1,benzene_ring
+195727,Remove a hydroxyl from the molecule COc1ccc(/C(Cl)=N/O)cc1.,COc1ccc(/C(Cl)=N/O)cc1,hydroxyl
+175486,Modify the molecule N#C/C(=C/c1cc2c(cc1[N+](=O)[O-])OCO2)S(=O)(=O)c1ccc(Cl)cc1 by removing a halo.,N#C/C(=C/c1cc2c(cc1[N+](=O)[O-])OCO2)S(=O)(=O)c1ccc(Cl)cc1,halo
+235946,Remove a amide from the molecule Cc1ccc(S(=O)(=O)N2CCOC23CCN(C(=O)C(=O)NCCC(C)C)CC3)cc1.,Cc1ccc(S(=O)(=O)N2CCOC23CCN(C(=O)C(=O)NCCC(C)C)CC3)cc1,amide
+219846,Remove a amide from the molecule C#CCNC(=O)COC(=O)c1sc(NC(=O)c2ccco2)cc1C.,C#CCNC(=O)COC(=O)c1sc(NC(=O)c2ccco2)cc1C,amide
+101768,Modify the molecule CCN(CC(C)(C)O)C(=O)CN1CCCCCC1=O by removing a amide.,CCN(CC(C)(C)O)C(=O)CN1CCCCCC1=O,amide
+90220,Please remove a amine from the molecule O=S(=O)(Nc1nc2ccc(Br)cc2s1)c1ccc(Cl)s1.,O=S(=O)(Nc1nc2ccc(Br)cc2s1)c1ccc(Cl)s1,amine
+24308,Please remove a benzene_ring from the molecule CC[C@](C)([C@@H](NC)c1ccc(F)c(C)c1)[NH+](C)C.,CC[C@](C)([C@@H](NC)c1ccc(F)c(C)c1)[NH+](C)C,benzene_ring
+233267,Remove a halo from the molecule COC(=O)c1ccccc1NC(=O)[C@H]1CCCCN1S(=O)(=O)c1ccc(Br)cc1.,COC(=O)c1ccccc1NC(=O)[C@H]1CCCCN1S(=O)(=O)c1ccc(Br)cc1,halo
+63678,Remove a amide from the molecule CC(C)NC(=O)c1ccc(NC(=O)c2cnns2)cc1.,CC(C)NC(=O)c1ccc(NC(=O)c2cnns2)cc1,amide
+230090,Modify the molecule CCOc1ccc(NC(=O)Nc2ccc(C)s2)cc1 by removing a benzene_ring.,CCOc1ccc(NC(=O)Nc2ccc(C)s2)cc1,benzene_ring
+74074,Please remove a benzene_ring from the molecule CCOc1ccc(-c2cc(Cl)ncn2)c(Cl)c1.,CCOc1ccc(-c2cc(Cl)ncn2)c(Cl)c1,benzene_ring
+112555,Please remove a amide from the molecule Cc1ccc(Cl)c(OCC(=O)N(C2CCCCC2)[C@H]2CCS(=O)(=O)C2)c1.,Cc1ccc(Cl)c(OCC(=O)N(C2CCCCC2)[C@H]2CCS(=O)(=O)C2)c1,amide
+17859,Please remove a benzene_ring from the molecule Fc1ccc(Br)c(C[NH+]2CCCNCC2)c1.,Fc1ccc(Br)c(C[NH+]2CCCNCC2)c1,benzene_ring
+231152,Modify the molecule O=C(NC[C@H]1CCC[C@@H](O)C1)NCC1(c2ccccc2)CCC1 by removing a hydroxyl.,O=C(NC[C@H]1CCC[C@@H](O)C1)NCC1(c2ccccc2)CCC1,hydroxyl
+6532,Modify the molecule O=C(NCCC1=c2ccccc2=[NH+]C1)c1ccc2c(c1)[C@H](c1ccccc1)ON2 by removing a amine.,O=C(NCCC1=c2ccccc2=[NH+]C1)c1ccc2c(c1)[C@H](c1ccccc1)ON2,amine
+156855,Modify the molecule COc1ccc2nc(-n3nc(C)cc3NC(=O)c3ccc([N+](=O)[O-])s3)sc2c1 by removing a nitro.,COc1ccc2nc(-n3nc(C)cc3NC(=O)c3ccc([N+](=O)[O-])s3)sc2c1,nitro
+155007,Remove a amine from the molecule CC(C)CCN(C(=O)[C@@H](C)/C(N)=N/O)C1CCCC1.,CC(C)CCN(C(=O)[C@@H](C)/C(N)=N/O)C1CCCC1,amine
+203272,Remove a halo from the molecule COc1ccc(CSc2nnc(C3CC3)n2-c2ccccc2)cc1F.,COc1ccc(CSc2nnc(C3CC3)n2-c2ccccc2)cc1F,halo
+62394,Modify the molecule CCc1ccc(O)c(C(=O)N2CCOC[C@@H]2C#N)c1 by removing a nitrile.,CCc1ccc(O)c(C(=O)N2CCOC[C@@H]2C#N)c1,nitrile
+62296,Please remove a amide from the molecule C#CCNCC(=O)N[C@@H](C)CS(C)(=O)=O.,C#CCNCC(=O)N[C@@H](C)CS(C)(=O)=O,amide
+52256,Please remove a benzene_ring from the molecule C[NH+](C)[C@@H](CNC(=O)C12CC3CC(CC(C3)C1)C2)c1ccccc1.,C[NH+](C)[C@@H](CNC(=O)C12CC3CC(CC(C3)C1)C2)c1ccccc1,benzene_ring
+163370,Please remove a amine from the molecule Cc1ccc2oc(=O)n(C[NH+]3CCC[C@H](NS(C)(=O)=O)C3)c2c1.,Cc1ccc2oc(=O)n(C[NH+]3CCC[C@H](NS(C)(=O)=O)C3)c2c1,amine
+42076,Remove a benzene_ring from the molecule CCCc1ccc(S(=O)(=O)Nc2cccc(C)c2O)cc1.,CCCc1ccc(S(=O)(=O)Nc2cccc(C)c2O)cc1,benzene_ring
+2189,Please remove a amine from the molecule C/[NH+]=C(/NCc1[nH+]ccn1CC(C)C)N1C[C@H]2CC=CC[C@@H]2C1.,C/[NH+]=C(/NCc1[nH+]ccn1CC(C)C)N1C[C@H]2CC=CC[C@@H]2C1,amine
+21425,Modify the molecule CCC[C@@H](C)NC(=O)[C@H]1CCCN(C(=O)c2cccc3[nH]ccc23)C1 by removing a amide.,CCC[C@@H](C)NC(=O)[C@H]1CCCN(C(=O)c2cccc3[nH]ccc23)C1,amide
+216271,Remove a amide from the molecule Cc1ccc([N+](=O)[O-])cc1NC(=O)[C@@H]1CCCN(S(=O)(=O)c2ccc(F)cc2)C1.,Cc1ccc([N+](=O)[O-])cc1NC(=O)[C@@H]1CCCN(S(=O)(=O)c2ccc(F)cc2)C1,amide
+158492,Modify the molecule C[C@H]1[C@@H](C)N(C(=O)NCCc2ccc(N(C)C)cc2)CCS1(=O)=O by removing a benzene_ring.,C[C@H]1[C@@H](C)N(C(=O)NCCc2ccc(N(C)C)cc2)CCS1(=O)=O,benzene_ring
+246409,Remove a amide from the molecule CCOC(=O)c1ccc(NC(=O)c2c(C)cccc2C)c(O)c1.,CCOC(=O)c1ccc(NC(=O)c2c(C)cccc2C)c(O)c1,amide
+8538,Please remove a benzene_ring from the molecule COCCc1nc(C)c([C@H](C)[NH2+]Cc2ccccc2C)s1.,COCCc1nc(C)c([C@H](C)[NH2+]Cc2ccccc2C)s1,benzene_ring
+168291,Modify the molecule Cc1csc(NC(=O)COC(=O)c2ccccc2C(F)(F)F)n1 by removing a amide.,Cc1csc(NC(=O)COC(=O)c2ccccc2C(F)(F)F)n1,amide
+34278,Modify the molecule CCCOc1ccc(N2C(=O)C[C@H]([NH2+]Cc3ccc(F)cc3)C2=O)cc1 by removing a benzene_ring.,CCCOc1ccc(N2C(=O)C[C@H]([NH2+]Cc3ccc(F)cc3)C2=O)cc1,benzene_ring
+55765,Please remove a halo from the molecule C[C@H]([NH2+][C@H](C)[C@@H](C)C(=O)[O-])c1ccc(F)cc1.,C[C@H]([NH2+][C@H](C)[C@@H](C)C(=O)[O-])c1ccc(F)cc1,halo
+220658,Please remove a benzene_ring from the molecule C=C(C)COc1cccc(NC(=O)N2CC[C@@H](COCC)C2)c1.,C=C(C)COc1cccc(NC(=O)N2CC[C@@H](COCC)C2)c1,benzene_ring
+150659,Remove a halo from the molecule CC(C)(C)OC(=O)N1CC[C@@H](C[S@@](=O)Cc2ccc(Cl)nc2)C1.,CC(C)(C)OC(=O)N1CC[C@@H](C[S@@](=O)Cc2ccc(Cl)nc2)C1,halo
+171551,Modify the molecule COc1cccc(CNC(=O)C[C@H]2CCCCN2S(=O)(=O)c2ccc(F)cc2)c1 by removing a halo.,COc1cccc(CNC(=O)C[C@H]2CCCCN2S(=O)(=O)c2ccc(F)cc2)c1,halo
+70671,Modify the molecule CCOC(=O)CCNn1cnnc1 by removing a amine.,CCOC(=O)CCNn1cnnc1,amine
+94373,Modify the molecule C[C@H]1C[C@H]1NC(=O)N(C)CCc1ccccc1 by removing a benzene_ring.,C[C@H]1C[C@H]1NC(=O)N(C)CCc1ccccc1,benzene_ring
+19379,Please remove a halo from the molecule CC(C)[C@@H]1C[NH+](C(C)C)CCC(=O)N1Cc1ccc(F)cc1.,CC(C)[C@@H]1C[NH+](C(C)C)CCC(=O)N1Cc1ccc(F)cc1,halo
+89868,Modify the molecule Cc1ccccc1-c1nnc(CS(=O)(=O)Cc2ccccc2)o1 by removing a benzene_ring.,Cc1ccccc1-c1nnc(CS(=O)(=O)Cc2ccccc2)o1,benzene_ring
+157479,Please remove a halo from the molecule C/C(=C\c1cccc(Cl)c1)C(=O)N1CC[C@@H](C)[C@H](O)C1.,C/C(=C\c1cccc(Cl)c1)C(=O)N1CC[C@@H](C)[C@H](O)C1,halo
+6410,Please remove a amine from the molecule Cc1cc(S(=O)(=O)NCC[NH+]2CCN(c3ccccc3)CC2)ccc1F.,Cc1cc(S(=O)(=O)NCC[NH+]2CCN(c3ccccc3)CC2)ccc1F,amine
+95275,Remove a amide from the molecule CCOC(=O)c1csc(CNC(=O)/C=C/c2ccnc(Cl)c2)n1.,CCOC(=O)c1csc(CNC(=O)/C=C/c2ccnc(Cl)c2)n1,amide
+172926,Modify the molecule [NH3+][C@@H](CC12CC3CC(CC(C3)C1)C2)c1ccc(Br)s1 by removing a halo.,[NH3+][C@@H](CC12CC3CC(CC(C3)C1)C2)c1ccc(Br)s1,halo
+113648,Remove a amide from the molecule Cn1cccc1C(=O)NNC(=O)c1ccc(Cl)c(Cl)c1.,Cn1cccc1C(=O)NNC(=O)c1ccc(Cl)c(Cl)c1,amide
+20534,Remove a halo from the molecule O=C(CCC(=O)N1CCC(c2ccccc2)=N1)Nc1ccc(SC(F)F)cc1.,O=C(CCC(=O)N1CCC(c2ccccc2)=N1)Nc1ccc(SC(F)F)cc1,halo
+17453,Please remove a halo from the molecule O=C1NCCN1[C@H]1CCC[NH+](C[C@@H]2CC(c3ccc(Cl)cc3)=NO2)C1.,O=C1NCCN1[C@H]1CCC[NH+](C[C@@H]2CC(c3ccc(Cl)cc3)=NO2)C1,halo
+121080,Modify the molecule COC(=O)c1ccc(NC(=O)Cn2cccc(-c3nc(-c4ccc(Cl)cc4)no3)c2=O)cc1 by removing a amide.,COC(=O)c1ccc(NC(=O)Cn2cccc(-c3nc(-c4ccc(Cl)cc4)no3)c2=O)cc1,amide
+196158,Remove a nitrile from the molecule CC(C)[C@@H](Oc1ccccc1C#N)C(=O)N1CCN(C[C@H](C)O)CC1.,CC(C)[C@@H](Oc1ccccc1C#N)C(=O)N1CCN(C[C@H](C)O)CC1,nitrile
+117927,Please remove a amine from the molecule CC(C)(C)CC(C)(C)NC(=S)N[C@H]1C[C@H]2CC[C@@H]1C2.,CC(C)(C)CC(C)(C)NC(=S)N[C@H]1C[C@H]2CC[C@@H]1C2,amine
+52872,Please remove a halo from the molecule COc1ccc(CNC(=O)Cn2cnc3c(c(C)c(C)n3-c3ccc(Cl)cc3)c2=O)cc1.,COc1ccc(CNC(=O)Cn2cnc3c(c(C)c(C)n3-c3ccc(Cl)cc3)c2=O)cc1,halo
+157681,Modify the molecule C[C@@H]1OCC[C@H]1C(=O)N[C@@H]1CC(=O)N(CC(F)(F)F)C1 by removing a amide.,C[C@@H]1OCC[C@H]1C(=O)N[C@@H]1CC(=O)N(CC(F)(F)F)C1,amide
+174710,Remove a halo from the molecule C[C@H]1C[C@@H](N(C)C(=O)CSCC(F)(F)F)CC[NH+]1C.,C[C@H]1C[C@@H](N(C)C(=O)CSCC(F)(F)F)CC[NH+]1C,halo
+21467,Modify the molecule O=C(CN1C(=O)[C@H]2[C@@H]3C=C[C@@H](C3)[C@@H]2C1=O)N1CCN(c2ccccc2Cl)CC1 by removing a benzene_ring.,O=C(CN1C(=O)[C@H]2[C@@H]3C=C[C@@H](C3)[C@@H]2C1=O)N1CCN(c2ccccc2Cl)CC1,benzene_ring
+209134,Modify the molecule COCc1ccc(CNC(=O)N[C@@H](CO)c2ccc(Cl)cc2)cc1 by removing a halo.,COCc1ccc(CNC(=O)N[C@@H](CO)c2ccc(Cl)cc2)cc1,halo
+91242,Please remove a halo from the molecule Cc1cc(-n2c(C)cn(CN3CCC(O)(C(F)(F)F)CC3)c2=O)no1.,Cc1cc(-n2c(C)cn(CN3CCC(O)(C(F)(F)F)CC3)c2=O)no1,halo
+108032,Remove a amine from the molecule CC[C@@H](C)[NH+](CC)[C@@H]1CCc2ccc(OC)cc2[C@@H]1NC.,CC[C@@H](C)[NH+](CC)[C@@H]1CCc2ccc(OC)cc2[C@@H]1NC,amine
+130100,Modify the molecule CCCC(=O)NC1CCCCC1 by removing a amide.,CCCC(=O)NC1CCCCC1,amide
+171000,Please remove a nitrile from the molecule N#CC1=C(N)C(C#N)(C#N)[C@H](c2ccc(COc3ccc(F)cc3F)o2)[C@@H]2CCCC=C12.,N#CC1=C(N)C(C#N)(C#N)[C@H](c2ccc(COc3ccc(F)cc3F)o2)[C@@H]2CCCC=C12,nitrile
+35201,Modify the molecule O=C(N[C@H](Cc1cc(=O)[nH]c(-c2ccccn2)n1)c1ccccc1)C1CCCC1 by removing a benzene_ring.,O=C(N[C@H](Cc1cc(=O)[nH]c(-c2ccccn2)n1)c1ccccc1)C1CCCC1,benzene_ring
+210825,Modify the molecule COc1ccccc1[C@@H]1O[C@H](C)Cn2c(-c3ccccc3)c3c(=O)n(C)c(=O)n(C)c3c21 by removing a benzene_ring.,COc1ccccc1[C@@H]1O[C@H](C)Cn2c(-c3ccccc3)c3c(=O)n(C)c(=O)n(C)c3c21,benzene_ring
+149935,Modify the molecule COc1ccc([C@H]2[C@@H](C(=O)NCc3ccccn3)c3ccccc3C(=O)N2c2ccc(OC)cc2)cc1 by removing a amide.,COc1ccc([C@H]2[C@@H](C(=O)NCc3ccccn3)c3ccccc3C(=O)N2c2ccc(OC)cc2)cc1,amide
+113709,Remove a amide from the molecule CC(C)C[C@@H]1COCCN1C(=O)NNC(=O)Cc1ccccn1.,CC(C)C[C@@H]1COCCN1C(=O)NNC(=O)Cc1ccccn1,amide
+55921,Remove a amide from the molecule COC(=O)c1s/c(=N/C(=O)[C@H]2CC(=O)N(CC(C)C)C2)[nH]c1C.,COC(=O)c1s/c(=N/C(=O)[C@H]2CC(=O)N(CC(C)C)C2)[nH]c1C,amide
+54500,Modify the molecule Cn1c(C[NH+]2CCCCC2)nc2cc(NS(=O)(=O)c3ccc(Cl)cc3)ccc21 by removing a halo.,Cn1c(C[NH+]2CCCCC2)nc2cc(NS(=O)(=O)c3ccc(Cl)cc3)ccc21,halo
+162986,Please remove a halo from the molecule COC(=O)c1ccccc1OS(=O)(=O)c1ccc(C)cc1Br.,COC(=O)c1ccccc1OS(=O)(=O)c1ccc(C)cc1Br,halo
+62452,Remove a amide from the molecule CNC(=O)NCC(=O)N1[C@@H](C)[C@@H](c2ccccc2)OC[C@H]1C.,CNC(=O)NCC(=O)N1[C@@H](C)[C@@H](c2ccccc2)OC[C@H]1C,amide
+106508,Modify the molecule CC1=C(C(N)=O)[C@H](c2ccc(Cl)cc2)n2nc(-c3cccc(Cl)c3)nc2N1 by removing a halo.,CC1=C(C(N)=O)[C@H](c2ccc(Cl)cc2)n2nc(-c3cccc(Cl)c3)nc2N1,halo
+78175,Modify the molecule C[NH2+][C@@H]1[C@@H](CN(C)c2ccc(OC)cc2)CCC1(C)C by removing a benzene_ring.,C[NH2+][C@@H]1[C@@H](CN(C)c2ccc(OC)cc2)CCC1(C)C,benzene_ring
+38337,Remove a amide from the molecule CN(Cc1ccco1)C(=O)[C@H]1C=C(Cn2cnc3ccccc32)N=N1.,CN(Cc1ccco1)C(=O)[C@H]1C=C(Cn2cnc3ccccc32)N=N1,amide
+194564,Modify the molecule CCCCCN(CCO)c1ncnc2ccc(F)cc12 by removing a hydroxyl.,CCCCCN(CCO)c1ncnc2ccc(F)cc12,hydroxyl
+37421,Remove a benzene_ring from the molecule CC[C@H](C)c1ccc(OCc2ccc(C(=O)OC)o2)cc1.,CC[C@H](C)c1ccc(OCc2ccc(C(=O)OC)o2)cc1,benzene_ring
+154245,Please remove a nitrile from the molecule Cn1ccc(-c2cccc(-c3ccc(C#N)cc3)c2)n1.,Cn1ccc(-c2cccc(-c3ccc(C#N)cc3)c2)n1,nitrile
+209256,Please remove a benzene_ring from the molecule COc1ccc(CC[C@H](C)NC(=O)Nc2cccnc2-n2cccn2)cc1.,COc1ccc(CC[C@H](C)NC(=O)Nc2cccnc2-n2cccn2)cc1,benzene_ring
+180421,Remove a benzene_ring from the molecule C[NH2+]C[C@]1(c2ccc(OCC(C)C)cc2)CC[C@H]1C.,C[NH2+]C[C@]1(c2ccc(OCC(C)C)cc2)CC[C@H]1C,benzene_ring
+18073,Please remove a nitrile from the molecule Cc1nn(-c2ccc(C#N)c(N)c2)c(C)c1Br.,Cc1nn(-c2ccc(C#N)c(N)c2)c(C)c1Br,nitrile
+220403,Modify the molecule O=C(N/N=C/c1cccc2ccccc12)c1ccccc1F by removing a amide.,O=C(N/N=C/c1cccc2ccccc12)c1ccccc1F,amide
+195922,Please remove a nitro from the molecule CC[NH+](CC)C[C@H](C)Nc1cc(C)c([N+](=O)[O-])cn1.,CC[NH+](CC)C[C@H](C)Nc1cc(C)c([N+](=O)[O-])cn1,nitro
+152164,Remove a benzene_ring from the molecule CCc1ccc([C@@H](C)NC(=O)C2CCN(S(C)(=O)=O)CC2)cc1.,CCc1ccc([C@@H](C)NC(=O)C2CCN(S(C)(=O)=O)CC2)cc1,benzene_ring
+77808,Please remove a hydroxyl from the molecule CC[C@H](O)Cc1ccc(OC)nc1.,CC[C@H](O)Cc1ccc(OC)nc1,hydroxyl
+98838,Modify the molecule C[C@@H](C1CC1)n1c(N)nc2c[nH+]ccc21 by removing a amine.,C[C@@H](C1CC1)n1c(N)nc2c[nH+]ccc21,amine
+165329,Remove a amine from the molecule C[C@H](Nc1ccc([NH+]2CCCCC2)cc1)C(=O)Nc1cccc([N+](=O)[O-])c1.,C[C@H](Nc1ccc([NH+]2CCCCC2)cc1)C(=O)Nc1cccc([N+](=O)[O-])c1,amine
+145858,Please remove a amine from the molecule Cc1ccc([C@@H]2CCCN2S(=O)(=O)N[C@@H](C)c2nncn2C)o1.,Cc1ccc([C@@H]2CCCN2S(=O)(=O)N[C@@H](C)c2nncn2C)o1,amine
+20899,Please remove a halo from the molecule C#Cc1cc(F)c(NC(=O)NCCCN2CCCCCC2=O)c(F)c1.,C#Cc1cc(F)c(NC(=O)NCCCN2CCCCCC2=O)c(F)c1,halo
+223990,Modify the molecule O=C(NC[C@](O)(c1ccccc1)C(F)(F)F)c1ccccc1Cl by removing a benzene_ring.,O=C(NC[C@](O)(c1ccccc1)C(F)(F)F)c1ccccc1Cl,benzene_ring
+208815,Please remove a halo from the molecule CN(C[C@H](O)C1CC1)c1cc(Cl)c(C(F)(F)F)cc1[N+](=O)[O-].,CN(C[C@H](O)C1CC1)c1cc(Cl)c(C(F)(F)F)cc1[N+](=O)[O-],halo
+21091,Please remove a benzene_ring from the molecule CC[C@H](C(=O)N1CCC(OCc2ccccc2C)CC1)c1c(C)noc1C.,CC[C@H](C(=O)N1CCC(OCc2ccccc2C)CC1)c1c(C)noc1C,benzene_ring
+196393,Please remove a halo from the molecule O=C(Nc1ccc(CN2C(=O)CCC2=O)cc1)c1cnc(Cl)c(Cl)c1.,O=C(Nc1ccc(CN2C(=O)CCC2=O)cc1)c1cnc(Cl)c(Cl)c1,halo
+154075,Modify the molecule Cc1ccc(NC(=O)[C@H]2CC(Cl)=CC[C@@H]2C(=O)[O-])cc1[N+](=O)[O-] by removing a halo.,Cc1ccc(NC(=O)[C@H]2CC(Cl)=CC[C@@H]2C(=O)[O-])cc1[N+](=O)[O-],halo
+113001,Modify the molecule Cc1cc(F)ccc1N[C@H]1CCCS[C@H]1C by removing a amine.,Cc1cc(F)ccc1N[C@H]1CCCS[C@H]1C,amine
+169493,Remove a benzene_ring from the molecule O=C(Nc1ccnc(-c2ccccc2)n1)c1cnn(-c2ccccc2)c1.,O=C(Nc1ccnc(-c2ccccc2)n1)c1cnn(-c2ccccc2)c1,benzene_ring
+90688,Please remove a halo from the molecule CCn1c(SCC(=O)Nc2ccc(Cl)cn2)nnc1-c1ccco1.,CCn1c(SCC(=O)Nc2ccc(Cl)cn2)nnc1-c1ccco1,halo
+78575,Remove a benzene_ring from the molecule CC(C)[C@H](OC(=O)[C@H]1CCS(=O)(=O)C1)c1cccc(C(F)(F)F)c1.,CC(C)[C@H](OC(=O)[C@H]1CCS(=O)(=O)C1)c1cccc(C(F)(F)F)c1,benzene_ring
+110887,Modify the molecule CNC(=O)c1cc(COc2ccc(NC(=O)c3cccc(C)c3)cc2)on1 by removing a benzene_ring.,CNC(=O)c1cc(COc2ccc(NC(=O)c3cccc(C)c3)cc2)on1,benzene_ring
+81049,Please remove a halo from the molecule Cc1cccc(C(C)C)c1NC(=O)N(CC[NH+](C)C)Cc1cccc(F)c1.,Cc1cccc(C(C)C)c1NC(=O)N(CC[NH+](C)C)Cc1cccc(F)c1,halo
+214979,Remove a benzene_ring from the molecule CCOc1ccc(C(=O)NCc2ccc(Br)cc2F)cc1OCC.,CCOc1ccc(C(=O)NCc2ccc(Br)cc2F)cc1OCC,benzene_ring
+104028,Remove a benzene_ring from the molecule C[C@H]1CCCCCN1c1ccc(S(N)(=O)=O)c(N)c1.,C[C@H]1CCCCCN1c1ccc(S(N)(=O)=O)c(N)c1,benzene_ring
+232057,Remove a amide from the molecule COCC(=O)NCc1cc2n(n1)CCC[NH+](Cc1ccc3occc3c1)C2.,COCC(=O)NCc1cc2n(n1)CCC[NH+](Cc1ccc3occc3c1)C2,amide
+194739,Please remove a benzene_ring from the molecule O=C1[NH+]=c2ccc(C(=O)NCc3cccc(Cl)c3)cc2=[NH+]C1=O.,O=C1[NH+]=c2ccc(C(=O)NCc3cccc(Cl)c3)cc2=[NH+]C1=O,benzene_ring
+183028,Please remove a halo from the molecule O=C1NN(c2cccc(Cl)c2)C(=O)/C1=C\c1ccc(-c2ccccc2)o1.,O=C1NN(c2cccc(Cl)c2)C(=O)/C1=C\c1ccc(-c2ccccc2)o1,halo
+208635,Modify the molecule CC(C)(C)OC(=O)Nc1ccccc1C(=O)N1CCC[C@@H]1CO by removing a benzene_ring.,CC(C)(C)OC(=O)Nc1ccccc1C(=O)N1CCC[C@@H]1CO,benzene_ring
+187224,Remove a benzene_ring from the molecule Cc1cc(Nc2ccccc2C(=O)[O-])nc(Nc2ccccc2C(=O)[O-])n1.,Cc1cc(Nc2ccccc2C(=O)[O-])nc(Nc2ccccc2C(=O)[O-])n1,benzene_ring
+120486,Remove a halo from the molecule C[C@H](CCc1ccccc1)NC(=O)Nc1ccc(OC(F)F)c(F)c1.,C[C@H](CCc1ccccc1)NC(=O)Nc1ccc(OC(F)F)c(F)c1,halo
+10410,Remove a amide from the molecule O=C(Oc1cccc(N2C(=O)[C@H]3CC=CC[C@@H]3C2=O)c1)c1ccc(Cl)cc1Cl.,O=C(Oc1cccc(N2C(=O)[C@H]3CC=CC[C@@H]3C2=O)c1)c1ccc(Cl)cc1Cl,amide
+122183,Remove a amide from the molecule CC(C)c1noc2ncc(C(=O)N3CCc4sccc4[C@H]3c3ccccc3)cc12.,CC(C)c1noc2ncc(C(=O)N3CCc4sccc4[C@H]3c3ccccc3)cc12,amide
+193921,Please remove a hydroxyl from the molecule O[C@@H]1CCCC[C@@H]1CC(F)(F)F.,O[C@@H]1CCCC[C@@H]1CC(F)(F)F,hydroxyl
+202915,Modify the molecule CC(C)[C@H](C#N)OC(=O)CCOC1CCOCC1 by removing a nitrile.,CC(C)[C@H](C#N)OC(=O)CCOC1CCOCC1,nitrile
+202083,Please remove a hydroxyl from the molecule Cc1ccc(NC(=O)N2CCc3ccc(O)cc3C2)s1.,Cc1ccc(NC(=O)N2CCc3ccc(O)cc3C2)s1,hydroxyl
+216451,Modify the molecule COc1ccccc1[C@H]1C(C(=O)OC[C@H]2CCCO2)=C(C)NC2=C1C(=O)CCC2 by removing a benzene_ring.,COc1ccccc1[C@H]1C(C(=O)OC[C@H]2CCCO2)=C(C)NC2=C1C(=O)CCC2,benzene_ring
+49923,Please remove a amide from the molecule CC(C)n1cc2cc(NC(=O)C(=O)NCC(C)(C)C(N)=O)ccc2n1.,CC(C)n1cc2cc(NC(=O)C(=O)NCC(C)(C)C(N)=O)ccc2n1,amide
+121729,Modify the molecule C=C(C)C[NH+]1CCC(NC(=O)c2c(O)cc(Cl)cc2Cl)CC1 by removing a hydroxyl.,C=C(C)C[NH+]1CCC(NC(=O)c2c(O)cc(Cl)cc2Cl)CC1,hydroxyl
+159921,Modify the molecule C[NH+]1CCCC[C@H]1c1ncc2c(n1)CCN(C(=O)CCC1CCCC1)C2 by removing a amide.,C[NH+]1CCCC[C@H]1c1ncc2c(n1)CCN(C(=O)CCC1CCCC1)C2,amide
+108772,Please remove a halo from the molecule COC(=O)[C@@H]1CCCC[C@@H]1OC(=O)c1ccc(F)c(NC(C)=O)c1.,COC(=O)[C@@H]1CCCC[C@@H]1OC(=O)c1ccc(F)c(NC(C)=O)c1,halo
+225275,Modify the molecule Cc1ccc(S(=O)(=O)Nc2ccc(S(=O)(=O)Nc3ccc(Cl)cc3)cc2)cc1[N+](=O)[O-] by removing a benzene_ring.,Cc1ccc(S(=O)(=O)Nc2ccc(S(=O)(=O)Nc3ccc(Cl)cc3)cc2)cc1[N+](=O)[O-],benzene_ring
+10600,Remove a halo from the molecule O=C1CCCC[C@@H]1[C@H]1CCCCN1C(=O)C(F)(F)F.,O=C1CCCC[C@@H]1[C@H]1CCCCN1C(=O)C(F)(F)F,halo
+97845,Modify the molecule COC[C@](C)(NC(=O)Nc1cn[nH]c1)c1ccccc1 by removing a benzene_ring.,COC[C@](C)(NC(=O)Nc1cn[nH]c1)c1ccccc1,benzene_ring
+218563,Please remove a amide from the molecule COc1cccc2sc(N3CCN(C(=O)[C@@H]4CCCN4S(=O)(=O)c4cccs4)CC3)nc12.,COc1cccc2sc(N3CCN(C(=O)[C@@H]4CCCN4S(=O)(=O)c4cccs4)CC3)nc12,amide
+79738,Please remove a hydroxyl from the molecule O/N=C1/CCCN(Cc2ccccc2)C1.,O/N=C1/CCCN(Cc2ccccc2)C1,hydroxyl
+244487,Modify the molecule CCN(CCO)C(=O)C[C@@H]1C(=O)NCCN1Cc1c(F)cccc1Cl by removing a hydroxyl.,CCN(CCO)C(=O)C[C@@H]1C(=O)NCCN1Cc1c(F)cccc1Cl,hydroxyl
+99634,Modify the molecule CC(=O)Nc1ccc(C)c(NC(=O)N2CCN(c3ccccc3F)CC2)c1 by removing a amide.,CC(=O)Nc1ccc(C)c(NC(=O)N2CCN(c3ccccc3F)CC2)c1,amide
+55624,Remove a amide from the molecule CS(=O)(=O)N(Cc1ccc(Cl)cc1)c1ccc(C(=O)Nc2ccccc2C(=O)[O-])cc1.,CS(=O)(=O)N(Cc1ccc(Cl)cc1)c1ccc(C(=O)Nc2ccccc2C(=O)[O-])cc1,amide
+233768,Please remove a amide from the molecule COc1cc(NC(=O)c2cc(C)oc2C)cc(OC)c1.,COc1cc(NC(=O)c2cc(C)oc2C)cc(OC)c1,amide
+221804,Please remove a hydroxyl from the molecule CC[NH+](CC)CCN1C(N)=[NH+]C[C@@H]1c1cccc(O)c1.,CC[NH+](CC)CCN1C(N)=[NH+]C[C@@H]1c1cccc(O)c1,hydroxyl
+240581,Remove a amine from the molecule CNc1ncccc1S(=O)(=O)N1CC[NH+]2CCCC[C@@H]2C1.,CNc1ncccc1S(=O)(=O)N1CC[NH+]2CCCC[C@@H]2C1,amine
+5993,Please remove a amine from the molecule Nc1c(C(=O)c2cccs2)sc2nsc(SCC[NH+]3CCCCC3)c12.,Nc1c(C(=O)c2cccs2)sc2nsc(SCC[NH+]3CCCCC3)c12,amine
+211177,Modify the molecule CCO[C@H]1C[C@@H]1C(=O)Nc1ccc(Sc2nncs2)c(Cl)c1 by removing a amide.,CCO[C@H]1C[C@@H]1C(=O)Nc1ccc(Sc2nncs2)c(Cl)c1,amide
+15978,Please remove a amine from the molecule Cn1c(=O)c2c(nc(N/N=C\C(Br)=C/c3ccccc3)n2Cc2ccccc2)n(C)c1=O.,Cn1c(=O)c2c(nc(N/N=C\C(Br)=C/c3ccccc3)n2Cc2ccccc2)n(C)c1=O,amine
+19272,Please remove a amide from the molecule N#Cc1ccccc1OCC(=O)NNC(=O)c1ccc2c(c1)CCCC2.,N#Cc1ccccc1OCC(=O)NNC(=O)c1ccc2c(c1)CCCC2,amide
+179635,Please remove a halo from the molecule O=C(CNc1ccc(-c2nnnn2C2CC2)cc1)N1N=C(c2ccc(Cl)cc2)C[C@H]1c1ccco1.,O=C(CNc1ccc(-c2nnnn2C2CC2)cc1)N1N=C(c2ccc(Cl)cc2)C[C@H]1c1ccco1,halo
+164070,Remove a amide from the molecule Cc1nc(C)c(C(=O)N2CCC[C@H](NC(=O)c3scnc3C)CC2)o1.,Cc1nc(C)c(C(=O)N2CCC[C@H](NC(=O)c3scnc3C)CC2)o1,amide
+214215,Remove a benzene_ring from the molecule N#Cc1cccc(CSc2nnc(C[C@H]3CCS(=O)(=O)C3)o2)c1.,N#Cc1cccc(CSc2nnc(C[C@H]3CCS(=O)(=O)C3)o2)c1,benzene_ring
+232789,Modify the molecule CCc1ccc(C(=O)O[C@@H](C)[C@@H]2CCCO2)cc1 by removing a benzene_ring.,CCc1ccc(C(=O)O[C@@H](C)[C@@H]2CCCO2)cc1,benzene_ring
+181001,Remove a amide from the molecule COc1ccc(CNC(=O)[C@H](C)N2Cc3ccccc3C2=O)cc1.,COc1ccc(CNC(=O)[C@H](C)N2Cc3ccccc3C2=O)cc1,amide
+83674,Remove a halo from the molecule CC(C)=C[C@@H]1[C@@H](C(=O)Nc2cc3c(cc2Cl)NC(=O)CO3)C1(C)C.,CC(C)=C[C@@H]1[C@@H](C(=O)Nc2cc3c(cc2Cl)NC(=O)CO3)C1(C)C,halo
+152287,Modify the molecule Cc1cnc([C@@H](C)NC(=O)NCC(=O)NC2CCCCC2)s1 by removing a amide.,Cc1cnc([C@@H](C)NC(=O)NCC(=O)NC2CCCCC2)s1,amide
+211766,Modify the molecule Cn1ccc2c(C(=O)N3CCC[C@H](c4nc[nH]n4)C3)cccc21 by removing a amide.,Cn1ccc2c(C(=O)N3CCC[C@H](c4nc[nH]n4)C3)cccc21,amide
+167808,Remove a benzene_ring from the molecule COc1cc(CC(=O)Nc2ccc(C)cn2)ccc1C.,COc1cc(CC(=O)Nc2ccc(C)cn2)ccc1C,benzene_ring
+79466,Modify the molecule O=C(COc1ccccc1)N1CCC(NS(=O)(=O)c2ccccc2)CC1 by removing a amide.,O=C(COc1ccccc1)N1CCC(NS(=O)(=O)c2ccccc2)CC1,amide
+237270,Remove a hydroxyl from the molecule COc1ccc(Br)c(C(=O)N2CCN(CCO)CC2)c1.,COc1ccc(Br)c(C(=O)N2CCN(CCO)CC2)c1,hydroxyl
+201053,Remove a amine from the molecule C[C@H](N[C@@H](C)c1nc2c(s1)CCCC2)c1ccc(-n2cncn2)cc1.,C[C@H](N[C@@H](C)c1nc2c(s1)CCCC2)c1ccc(-n2cncn2)cc1,amine
+140837,Remove a amide from the molecule CC[C@H](C)[C@@H](NC(=O)[C@@H]1Cc2ccccc2C[NH2+]1)C(=O)NC1CCCCC1.,CC[C@H](C)[C@@H](NC(=O)[C@@H]1Cc2ccccc2C[NH2+]1)C(=O)NC1CCCCC1,amide
+176441,Please remove a benzene_ring from the molecule COc1ccccc1[C@H](NC(=O)N[C@H](C)c1ccc(C)o1)c1nccn1C.,COc1ccccc1[C@H](NC(=O)N[C@H](C)c1ccc(C)o1)c1nccn1C,benzene_ring
+134932,Please remove a nitro from the molecule O=[N+]([O-])c1c(Nc2cc(Cl)cc(Cl)c2)ncnc1NC1CCCC1.,O=[N+]([O-])c1c(Nc2cc(Cl)cc(Cl)c2)ncnc1NC1CCCC1,nitro
+150527,Remove a benzene_ring from the molecule CC(=O)N(c1nc(CSCC(C)C)cs1)c1cccc(C)c1C.,CC(=O)N(c1nc(CSCC(C)C)cs1)c1cccc(C)c1C,benzene_ring
+232363,Modify the molecule COc1ccc2c(c1)CCCN2S(=O)(=O)c1ccc(C#N)cc1 by removing a nitrile.,COc1ccc2c(c1)CCCN2S(=O)(=O)c1ccc(C#N)cc1,nitrile
+204221,Remove a nitro from the molecule C=C(C)C[NH+](CC)Cc1cc([N+](=O)[O-])cc2c1OCOC2.,C=C(C)C[NH+](CC)Cc1cc([N+](=O)[O-])cc2c1OCOC2,nitro
+95196,Modify the molecule C[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC[C@@H]1C(=O)N(C)C by removing a halo.,C[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC[C@@H]1C(=O)N(C)C,halo
+65278,Please remove a hydroxyl from the molecule CCC[C@@H](C)C[C@H](O)c1ncc[nH]1.,CCC[C@@H](C)C[C@H](O)c1ncc[nH]1,hydroxyl
+3333,Remove a halo from the molecule COc1ccc2c(c1)c(CC(=O)Nc1ccccn1)c(C)n2C(=O)c1ccc(Cl)cc1.,COc1ccc2c(c1)c(CC(=O)Nc1ccccn1)c(C)n2C(=O)c1ccc(Cl)cc1,halo
+226506,Remove a amide from the molecule CCCc1nnc(NC(=O)c2cccc(S(C)(=O)=O)c2)s1.,CCCc1nnc(NC(=O)c2cccc(S(C)(=O)=O)c2)s1,amide
+100382,Remove a halo from the molecule CC(C)[C@H](C)NC(=O)N[C@H](C)c1ccc(F)c(Cl)c1.,CC(C)[C@H](C)NC(=O)N[C@H](C)c1ccc(F)c(Cl)c1,halo
+98069,Please remove a nitrile from the molecule N#CCC[C@H](C#N)CN1CCc2c(cccc2N2CCOC2=O)C1.,N#CCC[C@H](C#N)CN1CCc2c(cccc2N2CCOC2=O)C1,nitrile
+162607,Remove a benzene_ring from the molecule Cc1ccccc1NC(=O)c1sc(=S)n(-c2ccccc2F)c1N.,Cc1ccccc1NC(=O)c1sc(=S)n(-c2ccccc2F)c1N,benzene_ring
+6118,Modify the molecule CC(C)c1[nH+]ccn1CCN1CCN(C(=O)C(C)(C)Oc2ccc(Cl)cc2)CC1 by removing a halo.,CC(C)c1[nH+]ccn1CCN1CCN(C(=O)C(C)(C)Oc2ccc(Cl)cc2)CC1,halo
+187848,Modify the molecule N#Cc1cccnc1NCCNC(=O)c1ccc(F)nc1 by removing a amine.,N#Cc1cccnc1NCCNC(=O)c1ccc(F)nc1,amine
+150398,Remove a halo from the molecule Cc1cc(C[NH+](C)CC2CC(Cl)C2)c2ccccc2n1.,Cc1cc(C[NH+](C)CC2CC(Cl)C2)c2ccccc2n1,halo
+118870,Remove a benzene_ring from the molecule Cc1ccccc1N(C)CC[C@@H]1CCC[C@]1([NH3+])CO.,Cc1ccccc1N(C)CC[C@@H]1CCC[C@]1([NH3+])CO,benzene_ring
+211427,Modify the molecule Cc1nc2ccc(NC(=O)c3cccc(CS(C)(=O)=O)c3)cc2o1 by removing a benzene_ring.,Cc1nc2ccc(NC(=O)c3cccc(CS(C)(=O)=O)c3)cc2o1,benzene_ring
+109817,Remove a hydroxyl from the molecule CCOC(=O)CS[C@H]1CC(=O)N(c2ccc(O)cc2C)C1=O.,CCOC(=O)CS[C@H]1CC(=O)N(c2ccc(O)cc2C)C1=O,hydroxyl
+64721,Please remove a benzene_ring from the molecule Cc1cc(C)c(OCCCCn2cnc3ccccc3c2=O)c(C)c1.,Cc1cc(C)c(OCCCCn2cnc3ccccc3c2=O)c(C)c1,benzene_ring
+9313,Remove a benzene_ring from the molecule COc1ccccc1[C@@H](C)NC(=O)[C@H](C)Sc1cccc2cccnc12.,COc1ccccc1[C@@H](C)NC(=O)[C@H](C)Sc1cccc2cccnc12,benzene_ring
+177872,Modify the molecule C[C@H]1CCCCN1C(=O)CN1CC[NH+](CC(=O)Nc2ccccc2SCC#N)CC1 by removing a benzene_ring.,C[C@H]1CCCCN1C(=O)CN1CC[NH+](CC(=O)Nc2ccccc2SCC#N)CC1,benzene_ring
+150618,Remove a amine from the molecule O=[N+]([O-])c1c(NCCNS(=O)(=O)c2ccccc2)nc2ccccn12.,O=[N+]([O-])c1c(NCCNS(=O)(=O)c2ccccc2)nc2ccccn12,amine
+30735,Please remove a amine from the molecule C[C@H]1NC(C(=O)Nc2cnn(C)c2)=NN(c2ccccc2)C1=O.,C[C@H]1NC(C(=O)Nc2cnn(C)c2)=NN(c2ccccc2)C1=O,amine
+19439,Modify the molecule Cn1nccc1CNC(=O)C(=O)Nc1ccc(Oc2ccc(Cl)cc2)nc1 by removing a amide.,Cn1nccc1CNC(=O)C(=O)Nc1ccc(Oc2ccc(Cl)cc2)nc1,amide
+191248,Remove a benzene_ring from the molecule COc1ccc(F)c(NC(=O)N[C@@H](C)c2cc(OC)c(OC)cc2C)c1.,COc1ccc(F)c(NC(=O)N[C@@H](C)c2cc(OC)c(OC)cc2C)c1,benzene_ring
+245821,Remove a nitrile from the molecule N#CC(C#N)=C(N=C(c1ccccc1)c1ccccc1)C(F)(F)F.,N#CC(C#N)=C(N=C(c1ccccc1)c1ccccc1)C(F)(F)F,nitrile
+180364,Remove a nitrile from the molecule CCc1nc(CNc2ccccc2S[C@H](C)CC#N)no1.,CCc1nc(CNc2ccccc2S[C@H](C)CC#N)no1,nitrile
+137911,Modify the molecule CCc1ccc(/C([O-])=N/S(=O)(=O)c2ccc(C(C)=O)cc2)cc1 by removing a benzene_ring.,CCc1ccc(/C([O-])=N/S(=O)(=O)c2ccc(C(C)=O)cc2)cc1,benzene_ring
+194087,Modify the molecule N#C/C(C(=O)NC1CCCCC1)=C(\[O-])c1cccc(-c2ccoc2)c1 by removing a amide.,N#C/C(C(=O)NC1CCCCC1)=C(\[O-])c1cccc(-c2ccoc2)c1,amide
+89950,Remove a halo from the molecule CC1CCC(N(C)C(=O)Nc2cc(N3CCCC3=O)ccc2Cl)CC1.,CC1CCC(N(C)C(=O)Nc2cc(N3CCCC3=O)ccc2Cl)CC1,halo
+113007,Remove a hydroxyl from the molecule Cc1ccc2c(=O)n(C3CCC(O)CC3)cnc2c1C.,Cc1ccc2c(=O)n(C3CCC(O)CC3)cnc2c1C,hydroxyl
+185970,Remove a amide from the molecule CCOc1cn(-c2ccc(F)cc2)nc1C(=O)N1CCC(Cc2ccccc2)CC1.,CCOc1cn(-c2ccc(F)cc2)nc1C(=O)N1CCC(Cc2ccccc2)CC1,amide
+48781,Please remove a benzene_ring from the molecule CCCCNc1ccccc1OC(C)C.,CCCCNc1ccccc1OC(C)C,benzene_ring
+224983,Remove a halo from the molecule O=C(c1ccco1)N1CCN(c2ncc(Cl)cc2F)CC1.,O=C(c1ccco1)N1CCN(c2ncc(Cl)cc2F)CC1,halo
+108756,Modify the molecule N#Cc1csc(C(=O)NCC(=O)OC2CCCCC2)c1 by removing a amide.,N#Cc1csc(C(=O)NCC(=O)OC2CCCCC2)c1,amide
+155449,Please remove a amide from the molecule COc1ccc(NC(=O)c2ccc(Cn3nc(-n4cccc4)c4c(C)cc(C)nc43)cc2)cc1.,COc1ccc(NC(=O)c2ccc(Cn3nc(-n4cccc4)c4c(C)cc(C)nc43)cc2)cc1,amide
+68091,Remove a amide from the molecule CCS[C@@H]1CCC[C@@H](NC(=O)[C@@H]2CCC(=O)O2)C1.,CCS[C@@H]1CCC[C@@H](NC(=O)[C@@H]2CCC(=O)O2)C1,amide
+15855,Modify the molecule Cc1cccc(NC(=O)C[C@@H]2Nc3cc(C)c(C)cc3NC2=O)c1 by removing a amide.,Cc1cccc(NC(=O)C[C@@H]2Nc3cc(C)c(C)cc3NC2=O)c1,amide
+175289,Please remove a benzene_ring from the molecule C=C1C=C([O-])N2C(=NC(NCCC3=c4cc(OC)ccc4=[NH+]C3)=[NH+][C@@H]2c2ccccc2)N1.,C=C1C=C([O-])N2C(=NC(NCCC3=c4cc(OC)ccc4=[NH+]C3)=[NH+][C@@H]2c2ccccc2)N1,benzene_ring
+198116,Modify the molecule C/[NH+]=C(/NC[C@H](C)C#N)NC[C@@H]1CCC[NH+](C)C1 by removing a amine.,C/[NH+]=C(/NC[C@H](C)C#N)NC[C@@H]1CCC[NH+](C)C1,amine
+180490,Modify the molecule Cc1ccc(C(=O)Nc2nc(CN3C[C@H](C)O[C@@H](C)C3)cs2)cc1C by removing a benzene_ring.,Cc1ccc(C(=O)Nc2nc(CN3C[C@H](C)O[C@@H](C)C3)cs2)cc1C,benzene_ring
+42815,Modify the molecule CCOc1cc([C@@H]2C(C#N)=C(N)Oc3[nH]nc(C)c32)ccc1OC(F)F by removing a amine.,CCOc1cc([C@@H]2C(C#N)=C(N)Oc3[nH]nc(C)c32)ccc1OC(F)F,amine
+181752,Modify the molecule CC(C)(C)n1cc(C#N)c(NC(=O)C(=O)N2CC[C@H]([N+]3=CCCC3)C2)n1 by removing a amide.,CC(C)(C)n1cc(C#N)c(NC(=O)C(=O)N2CC[C@H]([N+]3=CCCC3)C2)n1,amide
+201414,Remove a halo from the molecule COc1ccc(OCC(=O)N2N=C3CCCC[C@@H]3[C@]2(O)C(F)(F)F)cc1.,COc1ccc(OCC(=O)N2N=C3CCCC[C@@H]3[C@]2(O)C(F)(F)F)cc1,halo
+104586,Modify the molecule C[C@H]1CCCN(C(=O)C2CCN(S(=O)(=O)c3cccc4nsnc34)CC2)C1 by removing a amide.,C[C@H]1CCCN(C(=O)C2CCN(S(=O)(=O)c3cccc4nsnc34)CC2)C1,amide
+134058,Remove a halo from the molecule Fc1ccc2nc(CN3CCC[C@H](c4nncn4C4CC4)C3)oc2c1.,Fc1ccc2nc(CN3CCC[C@H](c4nncn4C4CC4)C3)oc2c1,halo
+113187,Modify the molecule CCCn1c(=O)c2ccc(Cl)cc2n2c(SCc3cccc(OC)c3)nnc12 by removing a halo.,CCCn1c(=O)c2ccc(Cl)cc2n2c(SCc3cccc(OC)c3)nnc12,halo
+52942,Modify the molecule CC(=O)Nc1ccc(SCC(=O)Nc2cccc(Cl)c2Cl)cc1 by removing a halo.,CC(=O)Nc1ccc(SCC(=O)Nc2cccc(Cl)c2Cl)cc1,halo
+106490,Please remove a amine from the molecule CCc1nn(C)cc1NCc1ccccc1OC.,CCc1nn(C)cc1NCc1ccccc1OC,amine
+231232,Remove a amide from the molecule COc1ncccc1C(=O)N[C@@H]1CC(=O)N(C2CCCCCC2)C1.,COc1ncccc1C(=O)N[C@@H]1CC(=O)N(C2CCCCCC2)C1,amide
+248633,Modify the molecule CC(C)[C@@H]1Nc2ccc(Br)cc2NC1=O by removing a amide.,CC(C)[C@@H]1Nc2ccc(Br)cc2NC1=O,amide
+541,Modify the molecule N#Cc1cccc(NC(=O)N2CCC(NC(=O)CC3CCCC3)CC2)c1 by removing a nitrile.,N#Cc1cccc(NC(=O)N2CCC(NC(=O)CC3CCCC3)CC2)c1,nitrile
+230546,Remove a benzene_ring from the molecule O=C(OCc1cc(=O)oc2cc(O)c(O)cc12)c1nn(-c2ccccc2)c(=O)c2ccccc12.,O=C(OCc1cc(=O)oc2cc(O)c(O)cc12)c1nn(-c2ccccc2)c(=O)c2ccccc12,benzene_ring
+202207,Remove a benzene_ring from the molecule CC[NH2+][C@H]1CC[C@@H](Cc2cccc(O)c2)C1.,CC[NH2+][C@H]1CC[C@@H](Cc2cccc(O)c2)C1,benzene_ring
+245849,Modify the molecule Cc1cc2c(cc1C)O[C@@H](C(=O)N1CCC[C@@H](CCC(N)=O)C1)C2 by removing a amide.,Cc1cc2c(cc1C)O[C@@H](C(=O)N1CCC[C@@H](CCC(N)=O)C1)C2,amide
+40155,Please remove a amide from the molecule NC(=O)c1ccc(C(=O)Nc2ccc(N3CCSCC3)c(Cl)c2)cc1.,NC(=O)c1ccc(C(=O)Nc2ccc(N3CCSCC3)c(Cl)c2)cc1,amide
+93725,Please remove a halo from the molecule Cc1ccccc1CNC(=O)c1nn2ccccc2c1Cl.,Cc1ccccc1CNC(=O)c1nn2ccccc2c1Cl,halo
+200110,Please remove a halo from the molecule O=S1(=O)C[C@H]2Sc3nncn3[C@@H]2[C@H]1Br.,O=S1(=O)C[C@H]2Sc3nncn3[C@@H]2[C@H]1Br,halo
+99222,Please remove a amide from the molecule Cc1cc(=O)n(CC(=O)N2CCC(c3[nH+]ccn3C)CC2)c2ccccc12.,Cc1cc(=O)n(CC(=O)N2CCC(c3[nH+]ccn3C)CC2)c2ccccc12,amide
+117219,Modify the molecule CC(C)[C@H](NC(=O)c1c(F)cccc1F)C(=O)NCC[NH+]1CCc2ccccc2C1 by removing a benzene_ring.,CC(C)[C@H](NC(=O)c1c(F)cccc1F)C(=O)NCC[NH+]1CCc2ccccc2C1,benzene_ring
+16908,Please remove a halo from the molecule Cc1cc(C(F)(F)F)nc2nc(NC(=O)c3ccco3)ccc12.,Cc1cc(C(F)(F)F)nc2nc(NC(=O)c3ccco3)ccc12,halo
+140775,Please remove a hydroxyl from the molecule Cc1c(C(=O)N2CCCCC[C@H]2C[C@@H](O)c2ccco2)cnn1C.,Cc1c(C(=O)N2CCCCC[C@H]2C[C@@H](O)c2ccco2)cnn1C,hydroxyl
+148093,Modify the molecule CC[C@@H](C)[C@@H](NC(=O)c1ccccc1)C(=O)N1CCCSCC1 by removing a amide.,CC[C@@H](C)[C@@H](NC(=O)c1ccccc1)C(=O)N1CCCSCC1,amide
+180926,Modify the molecule CCCCN1C(=O)c2oc3cc(C)cc(C)c3c(=O)c2[C@H]1c1cccc(O)c1 by removing a hydroxyl.,CCCCN1C(=O)c2oc3cc(C)cc(C)c3c(=O)c2[C@H]1c1cccc(O)c1,hydroxyl
+18291,Modify the molecule COc1ccc(C2=CC[NH+]([C@H](C)c3nnc(C)o3)CC2)cc1 by removing a benzene_ring.,COc1ccc(C2=CC[NH+]([C@H](C)c3nnc(C)o3)CC2)cc1,benzene_ring
+28410,Please remove a amide from the molecule O=C1[C@H]2CC=CC[C@@H]2C(=O)N1CCN1CCCS1(=O)=O.,O=C1[C@H]2CC=CC[C@@H]2C(=O)N1CCN1CCCS1(=O)=O,amide
+31590,Remove a amide from the molecule CN1C(=O)N(CC(=O)[O-])C(=O)C12CCCCC2.,CN1C(=O)N(CC(=O)[O-])C(=O)C12CCCCC2,amide
+28232,Please remove a halo from the molecule N#Cc1ccc(Oc2ccnc(-c3ccccc3)n2)c(Cl)c1.,N#Cc1ccc(Oc2ccnc(-c3ccccc3)n2)c(Cl)c1,halo
+190926,Modify the molecule CCCC(=O)NCC(=O)N1CCCC[C@@H]1Cc1ccccc1 by removing a amide.,CCCC(=O)NCC(=O)N1CCCC[C@@H]1Cc1ccccc1,amide
+157048,Please remove a benzene_ring from the molecule Cc1nc(C(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)c(=O)[nH]c1C.,Cc1nc(C(=O)Nc2ccc(C(=O)OC(C)(C)C)cc2)c(=O)[nH]c1C,benzene_ring
+27580,Please remove a amide from the molecule O=C(c1ccc(=O)n(-c2ccccc2)n1)N1C[C@H]2CCC[C@@H]2C1.,O=C(c1ccc(=O)n(-c2ccccc2)n1)N1C[C@H]2CCC[C@@H]2C1,amide
+138224,Remove a benzene_ring from the molecule COc1ccccc1/C=C\C=c1/sc2nc(-c3ccccc3OC(C)=O)nn2c1=O.,COc1ccccc1/C=C\C=c1/sc2nc(-c3ccccc3OC(C)=O)nn2c1=O,benzene_ring
+179632,Please remove a benzene_ring from the molecule Cc1ccoc1C(=O)OCCCn1nnc(-c2ccccc2)n1.,Cc1ccoc1C(=O)OCCCn1nnc(-c2ccccc2)n1,benzene_ring
+139752,Modify the molecule O=C1CNC(=O)N1CCCn1nnc(-c2ccc(Br)cc2)n1 by removing a benzene_ring.,O=C1CNC(=O)N1CCCn1nnc(-c2ccc(Br)cc2)n1,benzene_ring
+196207,Remove a halo from the molecule COCCCNC(=O)c1cccc2c1N[C@H](c1ccccc1Cl)[C@H]1CC=C[C@@H]21.,COCCCNC(=O)c1cccc2c1N[C@H](c1ccccc1Cl)[C@H]1CC=C[C@@H]21,halo
+199404,Remove a amide from the molecule O=C(CCCc1ccccc1)Nc1c(C(=O)Nc2ccc3c(c2)OCCO3)oc2ccccc12.,O=C(CCCc1ccccc1)Nc1c(C(=O)Nc2ccc3c(c2)OCCO3)oc2ccccc12,amide
+64628,Modify the molecule C=CCCCN(C)c1cc[nH+]c(CN2CCN(C(C)=O)CC2)c1 by removing a amide.,C=CCCCN(C)c1cc[nH+]c(CN2CCN(C(C)=O)CC2)c1,amide
+46410,Modify the molecule CC(=O)c1cccc(OCC(=O)NC2CCOCC2)c1 by removing a amide.,CC(=O)c1cccc(OCC(=O)NC2CCOCC2)c1,amide
+219843,Please remove a amine from the molecule Cc1nn(C)c(C)c1NC(=S)NCc1cccnc1.,Cc1nn(C)c(C)c1NC(=S)NCc1cccnc1,amine
+205563,Remove a halo from the molecule C=CCC[C@H](C)OC(=O)c1cc(NC(C)=O)ccc1F.,C=CCC[C@H](C)OC(=O)c1cc(NC(C)=O)ccc1F,halo
+92510,Modify the molecule COc1ccc(N2CCOCC2)c(NC(=O)c2cc(OC)c(OC)c(OC)c2)c1 by removing a amide.,COc1ccc(N2CCOCC2)c(NC(=O)c2cc(OC)c(OC)c(OC)c2)c1,amide
+101051,Please remove a amide from the molecule C[C@@H]([NH2+]C1CCN(C(=O)[C@@H]2COc3ccccc3O2)CC1)c1ccccn1.,C[C@@H]([NH2+]C1CCN(C(=O)[C@@H]2COc3ccccc3O2)CC1)c1ccccn1,amide
+10938,Please remove a nitro from the molecule CC[C@@H]1CCc2nc(NC(=O)c3ccc([N+](=O)[O-])o3)sc2C1.,CC[C@@H]1CCc2nc(NC(=O)c3ccc([N+](=O)[O-])o3)sc2C1,nitro
+69034,Remove a halo from the molecule COc1cc(C[NH+](C)CC(=O)N[C@H]2CCS(=O)(=O)C2)ccc1F.,COc1cc(C[NH+](C)CC(=O)N[C@H]2CCS(=O)(=O)C2)ccc1F,halo
+158024,Modify the molecule C[C@H]1CN(C(=O)CCc2cscn2)[C@H](C)CN1C(=O)OC(C)(C)C by removing a amide.,C[C@H]1CN(C(=O)CCc2cscn2)[C@H](C)CN1C(=O)OC(C)(C)C,amide
+166044,Modify the molecule CCc1ccccc1NC(=O)CCN1C[C@H](C(=O)[O-])CC1=O by removing a benzene_ring.,CCc1ccccc1NC(=O)CCN1C[C@H](C(=O)[O-])CC1=O,benzene_ring
+15270,Remove a amide from the molecule CSc1ccc(CCNC(=O)c2cc(=O)nc3sc(N4CCCCCC4)nn23)cc1.,CSc1ccc(CCNC(=O)c2cc(=O)nc3sc(N4CCCCCC4)nn23)cc1,amide
+42027,Remove a amine from the molecule CNC(SCc1cc2c(cc1Cl)OCO2)=C(C(C)=O)C(C)=O.,CNC(SCc1cc2c(cc1Cl)OCO2)=C(C(C)=O)C(C)=O,amine
+215948,Remove a nitrile from the molecule C[C@H]1CCCC[C@H]1NC(=O)N1CCC[NH+](Cc2ccc(C#N)cc2)CC1.,C[C@H]1CCCC[C@H]1NC(=O)N1CCC[NH+](Cc2ccc(C#N)cc2)CC1,nitrile
+48070,Remove a amide from the molecule CCOc1c(Cl)cc(C[NH+]2CCC(N3CCCCC3=O)CC2)cc1OC.,CCOc1c(Cl)cc(C[NH+]2CCC(N3CCCCC3=O)CC2)cc1OC,amide
+188329,Please remove a benzene_ring from the molecule CCOc1ccc(F)c(C(=O)N[C@H]2C[C@](C)(OC)C2(C)C)c1F.,CCOc1ccc(F)c(C(=O)N[C@H]2C[C@](C)(OC)C2(C)C)c1F,benzene_ring
+246917,Remove a benzene_ring from the molecule CCN(Cc1cnn(C)c1)S(=O)(=O)c1cccc(C(F)(F)F)c1.,CCN(Cc1cnn(C)c1)S(=O)(=O)c1cccc(C(F)(F)F)c1,benzene_ring
+181113,Remove a amide from the molecule Cc1ccccc1-n1nnnc1SCC(=O)Nc1ccccc1C(=O)NC1CCCC1.,Cc1ccccc1-n1nnnc1SCC(=O)Nc1ccccc1C(=O)NC1CCCC1,amide
+45650,Please remove a halo from the molecule CCc1nnc2sc(-c3ccc(OC)c(NC(=O)c4cc(Cl)c(OC)c(Cl)c4)c3)nn12.,CCc1nnc2sc(-c3ccc(OC)c(NC(=O)c4cc(Cl)c(OC)c(Cl)c4)c3)nn12,halo
+200495,Please remove a benzene_ring from the molecule CC[C@H](CSC)N(C)C(=O)[C@@H]1CN(Cc2ccccc2)CCO1.,CC[C@H](CSC)N(C)C(=O)[C@@H]1CN(Cc2ccccc2)CCO1,benzene_ring
+170673,Remove a benzene_ring from the molecule COc1ccc(-c2cc3c(=O)n(CC(=O)Nc4ccc(C(C)C)cc4)ccn3n2)cc1OC.,COc1ccc(-c2cc3c(=O)n(CC(=O)Nc4ccc(C(C)C)cc4)ccn3n2)cc1OC,benzene_ring
+203367,Modify the molecule Nc1ccc(NC(=O)C(F)(F)F)c(Cl)c1 by removing a amide.,Nc1ccc(NC(=O)C(F)(F)F)c(Cl)c1,amide
+108041,Please remove a halo from the molecule COC(=O)CNC(=O)c1cnn(-c2ccc(Cl)cc2)c1-n1cccc1.,COC(=O)CNC(=O)c1cnn(-c2ccc(Cl)cc2)c1-n1cccc1,halo
+196929,Remove a benzene_ring from the molecule COCCO[C@@H](C)C(=O)Nc1cc(F)c(F)cc1F.,COCCO[C@@H](C)C(=O)Nc1cc(F)c(F)cc1F,benzene_ring
+128241,Please remove a amide from the molecule CC1(C)CCN(C(=O)[C@@H]([NH3+])CC(=O)[O-])C1.,CC1(C)CCN(C(=O)[C@@H]([NH3+])CC(=O)[O-])C1,amide
+39225,Please remove a amide from the molecule Cc1nn(C)c2ncc(NC(=O)COc3ccc4ccccc4c3)cc12.,Cc1nn(C)c2ncc(NC(=O)COc3ccc4ccccc4c3)cc12,amide
+102452,Remove a benzene_ring from the molecule O=C(NCCC(=O)N1CCCC1)Nc1ccn(Cc2ccccc2)n1.,O=C(NCCC(=O)N1CCCC1)Nc1ccn(Cc2ccccc2)n1,benzene_ring
+75837,Modify the molecule O=C(c1cccnc1SC1CCCC1)N1CCC([C@H](O)c2ccccc2)CC1 by removing a amide.,O=C(c1cccnc1SC1CCCC1)N1CCC([C@H](O)c2ccccc2)CC1,amide
+179957,Remove a benzene_ring from the molecule CC(C)(CNC(=O)NCc1cccc(Cn2cncn2)c1)c1ccncc1.,CC(C)(CNC(=O)NCc1cccc(Cn2cncn2)c1)c1ccncc1,benzene_ring
+193543,Modify the molecule C=CCn1c(C)nnc1S[C@@H](C(=O)Nc1cccc(F)c1)C(C)C by removing a halo.,C=CCn1c(C)nnc1S[C@@H](C(=O)Nc1cccc(F)c1)C(C)C,halo
+152672,Remove a halo from the molecule CC1(C)COC(=O)[C@@H](Br)C1.,CC1(C)COC(=O)[C@@H](Br)C1,halo
+36799,Modify the molecule Cn1nccc1CNC(=O)c1cccc(C#N)c1 by removing a benzene_ring.,Cn1nccc1CNC(=O)c1cccc(C#N)c1,benzene_ring
+15117,Modify the molecule CCCOc1cc(C)ccc1NC(=O)N1CCCC[C@@H]1CN1CCCC1=O by removing a benzene_ring.,CCCOc1cc(C)ccc1NC(=O)N1CCCC[C@@H]1CN1CCCC1=O,benzene_ring
+20909,Please remove a hydroxyl from the molecule CS[C@@H](CO)[C@H](C)NC(=O)c1cn(C)nc1-c1ccccc1.,CS[C@@H](CO)[C@H](C)NC(=O)c1cn(C)nc1-c1ccccc1,hydroxyl
+42793,Please remove a amide from the molecule C[C@H]1CCC[C@@H](NC(=O)C(=O)Nc2ccc(Oc3ccc(F)cc3)nc2)C1.,C[C@H]1CCC[C@@H](NC(=O)C(=O)Nc2ccc(Oc3ccc(F)cc3)nc2)C1,amide
+232342,Modify the molecule Cc1nc(=O)[nH]c(C)c1CC(=O)Nc1sccc1C(=O)[O-] by removing a amide.,Cc1nc(=O)[nH]c(C)c1CC(=O)Nc1sccc1C(=O)[O-],amide
+193267,Please remove a hydroxyl from the molecule Cn1cc(C(=O)NC[C@@]2(O)CCCc3ccccc32)c(-c2ccccc2)n1.,Cn1cc(C(=O)NC[C@@]2(O)CCCc3ccccc32)c(-c2ccccc2)n1,hydroxyl
+207000,Please remove a halo from the molecule CC(C)(C)OC(=O)N1CC[NH+](Cc2ccc(Cl)nc2)[C@H](C(=O)[O-])C1.,CC(C)(C)OC(=O)N1CC[NH+](Cc2ccc(Cl)nc2)[C@H](C(=O)[O-])C1,halo
+162417,Modify the molecule C[NH2+][C@H](C)c1cnc(-c2cncc(Br)c2)nc1C by removing a halo.,C[NH2+][C@H](C)c1cnc(-c2cncc(Br)c2)nc1C,halo
+19613,Please remove a benzene_ring from the molecule C[C@@H]1CCc2cc(F)ccc2N1S(=O)(=O)CCOc1ccc(F)cc1.,C[C@@H]1CCc2cc(F)ccc2N1S(=O)(=O)CCOc1ccc(F)cc1,benzene_ring
+195832,Please remove a amine from the molecule C#CCN/C(NCC(C)(C)[NH+]1CCCCC1)=[NH+]/CC.,C#CCN/C(NCC(C)(C)[NH+]1CCCCC1)=[NH+]/CC,amine
+238455,Modify the molecule Cc1ccn2c(=O)c(C(=O)N3CCOC[C@@H]3C3CC3)cnc2c1 by removing a amide.,Cc1ccn2c(=O)c(C(=O)N3CCOC[C@@H]3C3CC3)cnc2c1,amide
+51754,Remove a halo from the molecule O=C(NCc1c(O)ccc2c1CCCC2)N[C@@H]1CCN(CC(F)(F)F)C1.,O=C(NCc1c(O)ccc2c1CCCC2)N[C@@H]1CCN(CC(F)(F)F)C1,halo
+139638,Please remove a benzene_ring from the molecule CC(C)(C)c1ccc(-c2csc(NC(=O)c3ccccc3OCC(N)=O)n2)cc1.,CC(C)(C)c1ccc(-c2csc(NC(=O)c3ccccc3OCC(N)=O)n2)cc1,benzene_ring
+222716,Please remove a nitro from the molecule N#C[C@@H]1COCCN1Cc1cc(O)ccc1[N+](=O)[O-].,N#C[C@@H]1COCCN1Cc1cc(O)ccc1[N+](=O)[O-],nitro
+160782,Remove a benzene_ring from the molecule CN(CC(=O)NCC[NH+](C)C)S(=O)(=O)c1cc(Cl)ccc1Cl.,CN(CC(=O)NCC[NH+](C)C)S(=O)(=O)c1cc(Cl)ccc1Cl,benzene_ring
+191903,Modify the molecule O=C(Cc1ccc(F)cc1)N1CCS[C@@H]1c1cccc(F)c1 by removing a benzene_ring.,O=C(Cc1ccc(F)cc1)N1CCS[C@@H]1c1cccc(F)c1,benzene_ring
+212213,Please remove a amide from the molecule Cc1cc(C(=O)NCc2ccc(NC(=O)C3CC3)cc2)cc(S(N)(=O)=O)c1C.,Cc1cc(C(=O)NCc2ccc(NC(=O)C3CC3)cc2)cc(S(N)(=O)=O)c1C,amide
+215283,Please remove a amine from the molecule C[C@H]1C[C@H](Nc2ncccc2C#N)C(=O)N1c1ccccc1.,C[C@H]1C[C@H](Nc2ncccc2C#N)C(=O)N1c1ccccc1,amine
+180890,Modify the molecule CC[NH+](Cc1ccc(-c2ccccc2OC)cc1)CC(C)(C)O by removing a hydroxyl.,CC[NH+](Cc1ccc(-c2ccccc2OC)cc1)CC(C)(C)O,hydroxyl
+181552,Modify the molecule C[C@H]([NH2+]Cc1ccc(C(N)=O)o1)c1cc(Br)ccc1F by removing a amide.,C[C@H]([NH2+]Cc1ccc(C(N)=O)o1)c1cc(Br)ccc1F,amide
+165127,Please remove a benzene_ring from the molecule CCOc1ccc(N(Cc2cc3cc(C)ccc3[nH]c2=O)C(=O)c2ccc([N+](=O)[O-])cc2)cc1.,CCOc1ccc(N(Cc2cc3cc(C)ccc3[nH]c2=O)C(=O)c2ccc([N+](=O)[O-])cc2)cc1,benzene_ring
+185805,Please remove a benzene_ring from the molecule Nc1c(Nc2nc3ccccc3s2)ncnc1Nc1ccccc1F.,Nc1c(Nc2nc3ccccc3s2)ncnc1Nc1ccccc1F,benzene_ring
+211725,Modify the molecule CCN1CCN(C(=O)[C@@H](C)n2c3ccccc3c3cnn(C)c(=O)c32)CC1 by removing a amide.,CCN1CCN(C(=O)[C@@H](C)n2c3ccccc3c3cnn(C)c(=O)c32)CC1,amide
+101456,Please remove a amine from the molecule CC[C@@H](C)N[C@@H]1CCCC[C@@H]1[NH3+].,CC[C@@H](C)N[C@@H]1CCCC[C@@H]1[NH3+],amine
+199955,Please remove a benzene_ring from the molecule Cc1cccc([C@@H]([C@H](C)[NH3+])N(C)C[C@@H]2CCC[NH+]2C)c1.,Cc1cccc([C@@H]([C@H](C)[NH3+])N(C)C[C@@H]2CCC[NH+]2C)c1,benzene_ring
+129516,Modify the molecule CN(C(=O)c1ccc(C(F)(F)F)cc1)[C@@H]1CCCN(c2ccccc2)C1 by removing a amide.,CN(C(=O)c1ccc(C(F)(F)F)cc1)[C@@H]1CCCN(c2ccccc2)C1,amide
+145588,Modify the molecule CN(C)c1ccc(CN(C(=O)c2sc3ccccc3c2Cl)[C@H]2CCS(=O)(=O)C2)cc1 by removing a halo.,CN(C)c1ccc(CN(C(=O)c2sc3ccccc3c2Cl)[C@H]2CCS(=O)(=O)C2)cc1,halo
+109196,Modify the molecule CSc1nc([O-])c(C(=O)N[C@@H](C)c2ccccc2C)cc1C#N by removing a benzene_ring.,CSc1nc([O-])c(C(=O)N[C@@H](C)c2ccccc2C)cc1C#N,benzene_ring
+211935,Modify the molecule CCc1nnc(NC(=O)c2noc3c2COc2ccc(C)cc2-3)s1 by removing a amide.,CCc1nnc(NC(=O)c2noc3c2COc2ccc(C)cc2-3)s1,amide
+37820,Please remove a benzene_ring from the molecule Cc1ccc(-n2nc(C(=O)[O-])c3c2CCC3)c(F)c1.,Cc1ccc(-n2nc(C(=O)[O-])c3c2CCC3)c(F)c1,benzene_ring
+220147,Remove a amide from the molecule Cn1nc(C(=O)Nc2ccccc2C(C)(C)C)ccc1=O.,Cn1nc(C(=O)Nc2ccccc2C(C)(C)C)ccc1=O,amide
+106260,Please remove a benzene_ring from the molecule Cc1cc(C)cc(OC(=O)[C@H](C)S(=O)(=O)c2ccc(F)cc2)c1.,Cc1cc(C)cc(OC(=O)[C@H](C)S(=O)(=O)c2ccc(F)cc2)c1,benzene_ring
+67238,Modify the molecule CCC(CC)N1C(=O)C2(CCCC2)NC(=O)C1(C)C by removing a amide.,CCC(CC)N1C(=O)C2(CCCC2)NC(=O)C1(C)C,amide
+203208,Modify the molecule CC(C)[C@@H]1Nc2ccc(C(=O)NCc3ccccc3Cl)cc2NC1=O by removing a halo.,CC(C)[C@@H]1Nc2ccc(C(=O)NCc3ccccc3Cl)cc2NC1=O,halo
+114012,Remove a benzene_ring from the molecule O=[N+]([O-])c1ccc(CN2CCN(CCn3cc[nH+]c3)CC2)cc1.,O=[N+]([O-])c1ccc(CN2CCN(CCn3cc[nH+]c3)CC2)cc1,benzene_ring
+968,Please remove a halo from the molecule CCc1nn(CC)c(C[C@@]2(C3CC3)CCC[NH2+]2)c1Br.,CCc1nn(CC)c(C[C@@]2(C3CC3)CCC[NH2+]2)c1Br,halo
+137518,Remove a amide from the molecule CCOc1cc2c(cc1/C=C/C(=O)NCC(C)(C)[NH+](C)C)O[C@@H](C)C2.,CCOc1cc2c(cc1/C=C/C(=O)NCC(C)(C)[NH+](C)C)O[C@@H](C)C2,amide
+152538,Please remove a amide from the molecule C[NH2+]C[C@@H](C)C(=O)NCCNC(C)=O.,C[NH2+]C[C@@H](C)C(=O)NCCNC(C)=O,amide
+84563,Modify the molecule COc1ccccc1N1C[C@H](C(=O)Nc2ccc(O)cc2)CC1=O by removing a amide.,COc1ccccc1N1C[C@H](C(=O)Nc2ccc(O)cc2)CC1=O,amide
+226174,Please remove a halo from the molecule COCC(=O)N/N=C/c1cc(Br)ccc1O.,COCC(=O)N/N=C/c1cc(Br)ccc1O,halo
+190493,Modify the molecule CCOC(=O)Nc1ccc(NC(=O)c2ccc3[nH]c4c(c3c2)CCCC4)cc1 by removing a benzene_ring.,CCOC(=O)Nc1ccc(NC(=O)c2ccc3[nH]c4c(c3c2)CCCC4)cc1,benzene_ring
+6861,Remove a hydroxyl from the molecule COc1ccc(C[C@H](O)Cc2ccn(C(C)C)n2)cn1.,COc1ccc(C[C@H](O)Cc2ccn(C(C)C)n2)cn1,hydroxyl
+217994,Please remove a benzene_ring from the molecule CSCCOC(=O)C1CCN(C(=O)c2ccc(F)cc2F)CC1.,CSCCOC(=O)C1CCN(C(=O)c2ccc(F)cc2F)CC1,benzene_ring
+185737,Modify the molecule CCCCCNC(=O)c1cc2c([nH]c1=O)CC[C@H](C)C2 by removing a amide.,CCCCCNC(=O)c1cc2c([nH]c1=O)CC[C@H](C)C2,amide
+83366,Remove a halo from the molecule C[C@H]([NH2+]CC1(CS(C)(=O)=O)CC1)c1ccc(N2CCCCC2)c(F)c1.,C[C@H]([NH2+]CC1(CS(C)(=O)=O)CC1)c1ccc(N2CCCCC2)c(F)c1,halo
+135144,Remove a amide from the molecule COCCN1C(=O)c2oc3cc(C)c(C)cc3c(=O)c2[C@@H]1c1ccc(OCC(N)=O)cc1.,COCCN1C(=O)c2oc3cc(C)c(C)cc3c(=O)c2[C@@H]1c1ccc(OCC(N)=O)cc1,amide
+232156,Modify the molecule C[C@@H](OC(=O)c1cccc(S(=O)(=O)N2CCc3ccccc3C2)c1)C(=O)c1ccccc1 by removing a benzene_ring.,C[C@@H](OC(=O)c1cccc(S(=O)(=O)N2CCc3ccccc3C2)c1)C(=O)c1ccccc1,benzene_ring
+237902,Remove a amide from the molecule CC[C@H](C)N(C)C(=O)[C@H]1CCC[NH2+][C@@H]1C.,CC[C@H](C)N(C)C(=O)[C@H]1CCC[NH2+][C@@H]1C,amide
+85217,Please remove a amide from the molecule COc1ccc([C@@H]2c3c(oc4ccc(C)cc4c3=O)C(=O)N2Cc2ccc(C)cc2)cc1OC.,COc1ccc([C@@H]2c3c(oc4ccc(C)cc4c3=O)C(=O)N2Cc2ccc(C)cc2)cc1OC,amide
+47792,Remove a benzene_ring from the molecule CN(Cc1ccc(F)c(F)c1)C[C@H](O)c1ccccc1Cl.,CN(Cc1ccc(F)c(F)c1)C[C@H](O)c1ccccc1Cl,benzene_ring
+190209,Modify the molecule Cc1noc(C)c1C[NH+](C)Cc1c(O)ccc2ccccc12 by removing a hydroxyl.,Cc1noc(C)c1C[NH+](C)Cc1c(O)ccc2ccccc12,hydroxyl
+129256,Modify the molecule O=C(CCCNC(=O)[C@@H]1COc2ccccc2O1)Nc1nc2ccccc2s1 by removing a amide.,O=C(CCCNC(=O)[C@@H]1COc2ccccc2O1)Nc1nc2ccccc2s1,amide
+232539,Please remove a benzene_ring from the molecule OC[C@H](Nc1cccc(Br)c1)c1cccc(C2CC2)c1.,OC[C@H](Nc1cccc(Br)c1)c1cccc(C2CC2)c1,benzene_ring
+74504,Remove a halo from the molecule CCn1c(=O)c(N2CCC(C(=O)Nc3cccc(Cl)c3)CC2)c(C)n(-c2ccccc2)c1=O.,CCn1c(=O)c(N2CCC(C(=O)Nc3cccc(Cl)c3)CC2)c(C)n(-c2ccccc2)c1=O,halo
+240977,Modify the molecule COCc1cc(C(=O)NCC(=O)N2CCc3ccccc3C2)no1 by removing a amide.,COCc1cc(C(=O)NCC(=O)N2CCc3ccccc3C2)no1,amide
+193256,Remove a benzene_ring from the molecule CC(C)(C)c1ccc(NC(=O)/C=C/c2ccc(S(C)(=O)=O)cc2)cc1.,CC(C)(C)c1ccc(NC(=O)/C=C/c2ccc(S(C)(=O)=O)cc2)cc1,benzene_ring
+171420,Remove a amide from the molecule C[C@@H](NC(=O)C(C)(C)C)c1nc2ccccc2n1CC(=O)N(C)c1ccccc1.,C[C@@H](NC(=O)C(C)(C)C)c1nc2ccccc2n1CC(=O)N(C)c1ccccc1,amide
+56137,Remove a hydroxyl from the molecule CC[C@H]1CC[C@H]([C@H](O)Cc2cccc(O)c2)C1.,CC[C@H]1CC[C@H]([C@H](O)Cc2cccc(O)c2)C1,hydroxyl
+30536,Remove a amide from the molecule O=C1CSc2ccc(NC(=O)c3cccc4cn[nH]c34)cc2N1.,O=C1CSc2ccc(NC(=O)c3cccc4cn[nH]c34)cc2N1,amide
+144929,Modify the molecule N#C[C@@]1([C@@H](O)c2ccc3c(c2)OCCO3)CCOC1 by removing a nitrile.,N#C[C@@]1([C@@H](O)c2ccc3c(c2)OCCO3)CCOC1,nitrile
+182837,Remove a benzene_ring from the molecule Cc1ccc(-c2nc(C)sc2CC(=O)Nc2ccccc2)cc1.,Cc1ccc(-c2nc(C)sc2CC(=O)Nc2ccccc2)cc1,benzene_ring
+181972,Modify the molecule CCS(=O)(=O)CCn1ccc(NC(=O)c2ccccc2C)n1 by removing a amide.,CCS(=O)(=O)CCn1ccc(NC(=O)c2ccccc2C)n1,amide
+123394,Modify the molecule O=C1N[C@@]2(CCc3ccccc32)C(=O)N1Cc1nnc(-c2ccco2)o1 by removing a amide.,O=C1N[C@@]2(CCc3ccccc32)C(=O)N1Cc1nnc(-c2ccco2)o1,amide
+65181,Please remove a amide from the molecule CN(Cc1ccco1)C(=O)Cn1cnc2sc(-c3ccccc3)cc2c1=O.,CN(Cc1ccco1)C(=O)Cn1cnc2sc(-c3ccccc3)cc2c1=O,amide
+68552,Remove a benzene_ring from the molecule CCOC(=O)[C@H]1C(=O)N=C(N2CC[NH+](CC)CC2)[N-][C@H]1c1cccc(Cl)c1.,CCOC(=O)[C@H]1C(=O)N=C(N2CC[NH+](CC)CC2)[N-][C@H]1c1cccc(Cl)c1,benzene_ring
+40465,Remove a amide from the molecule C[C@H](C[NH+]1CCCCC1)NC(=O)c1cccs1.,C[C@H](C[NH+]1CCCCC1)NC(=O)c1cccs1,amide
+89622,Please remove a amide from the molecule CCc1ccc([C@H](C)C(=O)N(CCC(N)=O)c2ccc(F)cc2)cc1.,CCc1ccc([C@H](C)C(=O)N(CCC(N)=O)c2ccc(F)cc2)cc1,amide
+77428,Remove a benzene_ring from the molecule CC[C@H](NC(=O)c1ccc(CNC(C)=O)cc1)c1cccc(Cl)c1.,CC[C@H](NC(=O)c1ccc(CNC(C)=O)cc1)c1cccc(Cl)c1,benzene_ring
+225010,Modify the molecule CC(C)c1[nH+]ccn1CCN1CCN(C(=O)c2ccc(S(=O)(=O)N3CCCC3)cc2)CC1 by removing a benzene_ring.,CC(C)c1[nH+]ccn1CCN1CCN(C(=O)c2ccc(S(=O)(=O)N3CCCC3)cc2)CC1,benzene_ring
+111314,Remove a halo from the molecule COc1ccc(CN2CCN(C(=O)Cn3cncn3)CC2)cc1F.,COc1ccc(CN2CCN(C(=O)Cn3cncn3)CC2)cc1F,halo
+134416,Modify the molecule CC1(CNc2ccc([N+](=O)[O-])c(N)n2)CCCC1 by removing a nitro.,CC1(CNc2ccc([N+](=O)[O-])c(N)n2)CCCC1,nitro
+161325,Remove a benzene_ring from the molecule Cc1ccc(C(=O)N2CCN(C(=O)Nc3cccc(C)c3)CC2)cc1.,Cc1ccc(C(=O)N2CCN(C(=O)Nc3cccc(C)c3)CC2)cc1,benzene_ring
+179631,Remove a halo from the molecule Cc1nn(C)cc1-c1cc(C(F)(F)F)nc(N2CCC[C@@H]2C(=O)[O-])n1.,Cc1nn(C)cc1-c1cc(C(F)(F)F)nc(N2CCC[C@@H]2C(=O)[O-])n1,halo
+204911,Remove a amine from the molecule CN[C@@]1(C(=O)OC)CCC[C@@H]([NH+]2CCC(COC)CC2)C1.,CN[C@@]1(C(=O)OC)CCC[C@@H]([NH+]2CCC(COC)CC2)C1,amine
+162366,Remove a nitrile from the molecule CC(C)[C@H](C#N)NC(=O)[C@]1(C)CCCO1.,CC(C)[C@H](C#N)NC(=O)[C@]1(C)CCCO1,nitrile
+170525,Modify the molecule CCc1ccccc1NC(=O)C(=O)NCc1ccccc1Cn1cccn1 by removing a benzene_ring.,CCc1ccccc1NC(=O)C(=O)NCc1ccccc1Cn1cccn1,benzene_ring
+7057,Remove a halo from the molecule CC[C@H]([NH2+]C1CCSCC1)c1ccc(Cl)cc1.,CC[C@H]([NH2+]C1CCSCC1)c1ccc(Cl)cc1,halo
+192128,Modify the molecule C[NH+](C1CCCC1)[C@H]1CC[C@]([NH3+])(CO)C1 by removing a hydroxyl.,C[NH+](C1CCCC1)[C@H]1CC[C@]([NH3+])(CO)C1,hydroxyl
+111284,Remove a amide from the molecule CCOc1cccc2sc(N(C[C@H]3CCCO3)C(=O)[C@@H]3Oc4ccccc4O[C@H]3C)nc12.,CCOc1cccc2sc(N(C[C@H]3CCCO3)C(=O)[C@@H]3Oc4ccccc4O[C@H]3C)nc12,amide
+211389,Please remove a benzene_ring from the molecule CCn1cc(-c2c(-c3ccccc3)ncn2CCNC(=O)c2cccnc2)cn1.,CCn1cc(-c2c(-c3ccccc3)ncn2CCNC(=O)c2cccnc2)cn1,benzene_ring
+88105,Modify the molecule COc1ccccc1CNc1ccc(NC(=O)[C@@H]2CCCO2)cc1 by removing a amide.,COc1ccccc1CNc1ccc(NC(=O)[C@@H]2CCCO2)cc1,amide
+128496,Modify the molecule Cc1ccc2c(c1)c(=O)c(S(=O)(=O)c1ccccc1)cn2CC(=O)Nc1ccc(C)c(Cl)c1 by removing a benzene_ring.,Cc1ccc2c(c1)c(=O)c(S(=O)(=O)c1ccccc1)cn2CC(=O)Nc1ccc(C)c(Cl)c1,benzene_ring
+229326,Please remove a benzene_ring from the molecule CC(=O)NCCNC(=O)NCc1ccc(CN2CCc3ccccc32)cc1.,CC(=O)NCCNC(=O)NCc1ccc(CN2CCc3ccccc32)cc1,benzene_ring
+116547,Please remove a halo from the molecule COc1cc(Cl)c(C)cc1NC(=O)CS(=O)(=O)Cc1cc(C)ccc1C.,COc1cc(Cl)c(C)cc1NC(=O)CS(=O)(=O)Cc1cc(C)ccc1C,halo
+193531,Remove a amide from the molecule COCC[S@](=O)[C@H](C)C(=O)Nc1ccc(F)c(Cl)c1.,COCC[S@](=O)[C@H](C)C(=O)Nc1ccc(F)c(Cl)c1,amide
+135060,Modify the molecule C[C@H](c1ccncc1)[NH+](C)CC(=O)N[C@@H](c1ccc(F)cc1)C1CCCC1 by removing a halo.,C[C@H](c1ccncc1)[NH+](C)CC(=O)N[C@@H](c1ccc(F)cc1)C1CCCC1,halo
+40400,Please remove a benzene_ring from the molecule C[C@@H](NC(=O)NCC(=O)Nc1ccccc1)c1ccc(Cl)s1.,C[C@@H](NC(=O)NCC(=O)Nc1ccccc1)c1ccc(Cl)s1,benzene_ring
+98636,Remove a amide from the molecule C[C@H](O)[C@@H](C)SCC(=O)Nc1ccccc1C(=O)Nc1ccccc1.,C[C@H](O)[C@@H](C)SCC(=O)Nc1ccccc1C(=O)Nc1ccccc1,amide
+13713,Remove a halo from the molecule COc1cc(C(=O)[O-])cc(-c2cc(Cl)ccc2OC)c1.,COc1cc(C(=O)[O-])cc(-c2cc(Cl)ccc2OC)c1,halo
+18965,Please remove a amide from the molecule Cc1cccc(C(=O)N[C@@H]2CCCC[C@@H]2C(F)(F)F)n1.,Cc1cccc(C(=O)N[C@@H]2CCCC[C@@H]2C(F)(F)F)n1,amide
+10545,Modify the molecule O=C(CNC(=O)N[C@@H]1C[C@H]1c1cccc(Cl)c1)NCc1ccccc1 by removing a amide.,O=C(CNC(=O)N[C@@H]1C[C@H]1c1cccc(Cl)c1)NCc1ccccc1,amide
+95249,Modify the molecule CC1(C)CCC([NH+]2CCCC[C@@H]2CC(N)=O)CC1 by removing a amide.,CC1(C)CCC([NH+]2CCCC[C@@H]2CC(N)=O)CC1,amide
+35403,Remove a amide from the molecule O=C(Nc1ccccc1N1CCCC1)c1ccc(-n2cncn2)nc1.,O=C(Nc1ccccc1N1CCCC1)c1ccc(-n2cncn2)nc1,amide
+110550,Please remove a amide from the molecule C[C@H](CC(=O)N(C)[C@H]1CCCC[C@@H]1S(C)(=O)=O)n1cccc1.,C[C@H](CC(=O)N(C)[C@H]1CCCC[C@@H]1S(C)(=O)=O)n1cccc1,amide
+157314,Remove a benzene_ring from the molecule CCc1nc(-c2cccc(OC)c2)nc(CC)c1CC[NH3+].,CCc1nc(-c2cccc(OC)c2)nc(CC)c1CC[NH3+],benzene_ring
+161878,Please remove a nitro from the molecule O=[N+]([O-])c1ccc(S(=O)(=O)NC[C@](O)(c2ccccc2)C(F)(F)F)cc1.,O=[N+]([O-])c1ccc(S(=O)(=O)NC[C@](O)(c2ccccc2)C(F)(F)F)cc1,nitro
+111711,Remove a amide from the molecule O=C(Nc1nc(-c2ccc(Cl)cc2)cs1)c1cc2c([nH]c1=O)CCCC2.,O=C(Nc1nc(-c2ccc(Cl)cc2)cs1)c1cc2c([nH]c1=O)CCCC2,amide
+82715,Modify the molecule OC/C=C(\Cl)c1ccc(Cl)cc1Cl by removing a halo.,OC/C=C(\Cl)c1ccc(Cl)cc1Cl,halo
+242509,Remove a benzene_ring from the molecule CCC[NH+]1CCC(CNC(=O)C(=O)Nc2ccc(F)c(C(N)=O)c2)CC1.,CCC[NH+]1CCC(CNC(=O)C(=O)Nc2ccc(F)c(C(N)=O)c2)CC1,benzene_ring
+170787,Remove a amine from the molecule CCCN1C(N)=[NH+]C[C@]12CC(C)(C)OC2(C)C.,CCCN1C(N)=[NH+]C[C@]12CC(C)(C)OC2(C)C,amine
+232277,Please remove a hydroxyl from the molecule O=C1N[C@@H](C(=O)NC[C@@H](O)c2cc(Cl)cc(Cl)c2)CS1.,O=C1N[C@@H](C(=O)NC[C@@H](O)c2cc(Cl)cc(Cl)c2)CS1,hydroxyl
+141952,Remove a amine from the molecule CNc1cccc(COc2cncc(Cl)c2)[nH+]1.,CNc1cccc(COc2cncc(Cl)c2)[nH+]1,amine
+214265,Please remove a benzene_ring from the molecule CCOc1cc(C=O)cc(Br)c1OC(=O)c1ccccc1Cl.,CCOc1cc(C=O)cc(Br)c1OC(=O)c1ccccc1Cl,benzene_ring
+240981,Remove a amide from the molecule COc1cccc(NC(=O)CCN2C(=O)[C@@H]3Cc4cc(OC)c(OC)cc4CN3C2=O)c1.,COc1cccc(NC(=O)CCN2C(=O)[C@@H]3Cc4cc(OC)c(OC)cc4CN3C2=O)c1,amide
+11121,Remove a amide from the molecule N#Cc1ccc(NC(=O)c2c3c(nc4ccccc24)CCC3)cc1Cl.,N#Cc1ccc(NC(=O)c2c3c(nc4ccccc24)CCC3)cc1Cl,amide
+186509,Please remove a amide from the molecule CC(C)[C@@H](CNC(=O)C(=O)Nc1ccccc1)N1CC[NH+](C)CC1.,CC(C)[C@@H](CNC(=O)C(=O)Nc1ccccc1)N1CC[NH+](C)CC1,amide
+38200,Remove a hydroxyl from the molecule Cc1nc2ncnn2c(N2CCC(O)(C(F)(F)F)CC2)c1C.,Cc1nc2ncnn2c(N2CCC(O)(C(F)(F)F)CC2)c1C,hydroxyl
+26496,Remove a amide from the molecule Cc1cc([C@H](C)NC(=O)C2CC=CC2)c(C)o1.,Cc1cc([C@H](C)NC(=O)C2CC=CC2)c(C)o1,amide
+215221,Please remove a benzene_ring from the molecule COc1ccccc1CNC(=O)NCc1ccc(OC(C)C)nc1.,COc1ccccc1CNC(=O)NCc1ccc(OC(C)C)nc1,benzene_ring
+203226,Remove a amide from the molecule COc1ccc(NC(=O)C[C@@H](NC(C)=O)c2ccc(Cl)cc2)c(OC)c1.,COc1ccc(NC(=O)C[C@@H](NC(C)=O)c2ccc(Cl)cc2)c(OC)c1,amide
+135649,Modify the molecule CN1C(SCc2ccc(Cl)c(Cl)c2)=N[C@@H]2CS(=O)(=O)C[C@H]21 by removing a benzene_ring.,CN1C(SCc2ccc(Cl)c(Cl)c2)=N[C@@H]2CS(=O)(=O)C[C@H]21,benzene_ring
+135961,Modify the molecule Cc1ccc2c(c1)C(=O)N(CCCC(=O)Nc1ccc(C#N)cc1)C2=O by removing a amide.,Cc1ccc2c(c1)C(=O)N(CCCC(=O)Nc1ccc(C#N)cc1)C2=O,amide
+227770,Please remove a amide from the molecule C[C@@H]1CCC[C@@H](NC(=O)c2ccc3c(c2)NC(=O)CO3)C1.,C[C@@H]1CCC[C@@H](NC(=O)c2ccc3c(c2)NC(=O)CO3)C1,amide
+164491,Remove a amide from the molecule C[C@@H](O)C[NH+]1CCC2(CCC(=O)N(Cc3ccccc3)C2)CC1.,C[C@@H](O)C[NH+]1CCC2(CCC(=O)N(Cc3ccccc3)C2)CC1,amide
+27378,Modify the molecule C[C@H](C(=O)c1ccc(F)cc1F)n1cnc2c1c(=O)n(C)c(=O)n2C by removing a halo.,C[C@H](C(=O)c1ccc(F)cc1F)n1cnc2c1c(=O)n(C)c(=O)n2C,halo
+37077,Remove a amide from the molecule O=C(NCc1ccc2c3c(cccc13)C(=O)N2)c1ccc(F)cc1.,O=C(NCc1ccc2c3c(cccc13)C(=O)N2)c1ccc(F)cc1,amide
+9996,Remove a benzene_ring from the molecule C[C@H]1C[C@@H]1C(=O)N1CCN(C(=O)CNC(=O)c2ccc(C#N)cc2)CC1.,C[C@H]1C[C@@H]1C(=O)N1CCN(C(=O)CNC(=O)c2ccc(C#N)cc2)CC1,benzene_ring
+34805,Please remove a benzene_ring from the molecule O=C(NC[C@@H]1COC2(CCCC2)O1)Nc1c(F)cccc1Oc1ccccc1.,O=C(NC[C@@H]1COC2(CCCC2)O1)Nc1c(F)cccc1Oc1ccccc1,benzene_ring
+219022,Modify the molecule CCOc1ccc([C@H]2CCCN2C(=O)Nc2ccc(OC)c(C)c2)cc1 by removing a benzene_ring.,CCOc1ccc([C@H]2CCCN2C(=O)Nc2ccc(OC)c(C)c2)cc1,benzene_ring
+34732,Modify the molecule O=C(CCNC(=O)c1cc2cccc(Cl)c2o1)NCc1ccccc1 by removing a halo.,O=C(CCNC(=O)c1cc2cccc(Cl)c2o1)NCc1ccccc1,halo
+174383,Please remove a amine from the molecule CNc1ccc(CN2CC[C@@H](CN3CCOCC3)C2)cc1[N+](=O)[O-].,CNc1ccc(CN2CC[C@@H](CN3CCOCC3)C2)cc1[N+](=O)[O-],amine
+345,Please remove a amide from the molecule Cn1c(=O)c(=O)n(CC(=O)N2CCC3(CC2)OCCO3)c2cccnc21.,Cn1c(=O)c(=O)n(CC(=O)N2CCC3(CC2)OCCO3)c2cccnc21,amide
+163982,Please remove a benzene_ring from the molecule COc1ccc(SCCC(=O)Oc2ccc3ccc(=O)oc3c2)cc1.,COc1ccc(SCCC(=O)Oc2ccc3ccc(=O)oc3c2)cc1,benzene_ring
+222733,Remove a benzene_ring from the molecule CC[C@H](CNC(=O)c1ccc([N+](=O)[O-])cc1F)c1ccccc1.,CC[C@H](CNC(=O)c1ccc([N+](=O)[O-])cc1F)c1ccccc1,benzene_ring
+9072,Remove a amide from the molecule C[C@@H]1CN(C(=O)Cn2cc([N+](=O)[O-])cn2)CCO1.,C[C@@H]1CN(C(=O)Cn2cc([N+](=O)[O-])cn2)CCO1,amide
+213306,Please remove a amide from the molecule CCCNC(=O)CNC(=O)Nc1ccccc1N1CC[NH+](CC)CC1.,CCCNC(=O)CNC(=O)Nc1ccccc1N1CC[NH+](CC)CC1,amide
+176380,Please remove a benzene_ring from the molecule C[C@H](NC(=O)c1ccc(Cl)cc1)C(=O)Nc1nc2ccccc2s1.,C[C@H](NC(=O)c1ccc(Cl)cc1)C(=O)Nc1nc2ccccc2s1,benzene_ring
+106472,Modify the molecule CN(C)c1ccc(/C=N/NC(=O)CSc2nnc(-c3ccncc3)n2N)cc1 by removing a benzene_ring.,CN(C)c1ccc(/C=N/NC(=O)CSc2nnc(-c3ccncc3)n2N)cc1,benzene_ring
+181514,Please remove a amide from the molecule C[NH+](CC(=O)NC(=O)Nc1ccc2c(c1)OCCO2)CC(=O)Nc1c(Cl)cccc1Cl.,C[NH+](CC(=O)NC(=O)Nc1ccc2c(c1)OCCO2)CC(=O)Nc1c(Cl)cccc1Cl,amide
+120310,Remove a amine from the molecule COc1ccc(C2=N[NH+]=C(N3CCN(C(=O)C(C)C)CC3)SC2)cc1.,COc1ccc(C2=N[NH+]=C(N3CCN(C(=O)C(C)C)CC3)SC2)cc1,amine
+235767,Please remove a benzene_ring from the molecule Cc1ccc(NC(=O)[C@@H]2C=C(c3ccncc3)N=N2)cc1N(C)C.,Cc1ccc(NC(=O)[C@@H]2C=C(c3ccncc3)N=N2)cc1N(C)C,benzene_ring
+192424,Modify the molecule CN(CC[NH+](C)C1CCCCC1)C(=O)CCn1nnc2ccccc2c1=O by removing a amide.,CN(CC[NH+](C)C1CCCCC1)C(=O)CCn1nnc2ccccc2c1=O,amide
+203330,Remove a benzene_ring from the molecule CCc1nnc(N2C(=O)c3oc4cc(OC)ccc4c(=O)c3[C@H]2c2cccc([N+](=O)[O-])c2)s1.,CCc1nnc(N2C(=O)c3oc4cc(OC)ccc4c(=O)c3[C@H]2c2cccc([N+](=O)[O-])c2)s1,benzene_ring
+159447,Modify the molecule CCOC(=O)c1c(-c2ccc3ccccc3c2)csc1NC(=O)c1cccnc1 by removing a amide.,CCOC(=O)c1c(-c2ccc3ccccc3c2)csc1NC(=O)c1cccnc1,amide
+103915,Please remove a benzene_ring from the molecule COc1ccc(S(=O)(=O)N2CCN(c3ccccc3OC)CC2)cc1F.,COc1ccc(S(=O)(=O)N2CCN(c3ccccc3OC)CC2)cc1F,benzene_ring
+134219,Please remove a hydroxyl from the molecule N#Cc1ccc(N2CCC(O)CC2)cc1.,N#Cc1ccc(N2CCC(O)CC2)cc1,hydroxyl
+245734,Please remove a amide from the molecule COC(=O)C[C@@H]1Oc2ccccc2N(Cc2snnc2C(C)C)C1=O.,COC(=O)C[C@@H]1Oc2ccccc2N(Cc2snnc2C(C)C)C1=O,amide
+71099,Remove a halo from the molecule Cc1[nH]nc(C(N)=O)c1NC(=O)CCC(F)(F)F.,Cc1[nH]nc(C(N)=O)c1NC(=O)CCC(F)(F)F,halo
+92395,Please remove a benzene_ring from the molecule C=CCOc1ccc(/C=C(\C#N)C(=O)c2c[nH]c3ccccc23)cc1.,C=CCOc1ccc(/C=C(\C#N)C(=O)c2c[nH]c3ccccc23)cc1,benzene_ring
+162610,Please remove a amide from the molecule Cc1ccc(C2(O)CC[NH+](CC(=O)N3C[C@H](C)O[C@H](C)C3)CC2)nc1.,Cc1ccc(C2(O)CC[NH+](CC(=O)N3C[C@H](C)O[C@H](C)C3)CC2)nc1,amide
+52632,Remove a amide from the molecule CCN(CC)c1ccc(C(=O)Nc2ccc3oc(COC)nc3c2)cn1.,CCN(CC)c1ccc(C(=O)Nc2ccc3oc(COC)nc3c2)cn1,amide
+193822,Please remove a amide from the molecule O=C(C1=C([O-])C(=O)N(CC[NH+]2CCCCC2)[C@@H]1c1cccnc1)C1CC1.,O=C(C1=C([O-])C(=O)N(CC[NH+]2CCCCC2)[C@@H]1c1cccnc1)C1CC1,amide
+103266,Please remove a benzene_ring from the molecule Cc1ccc(Cn2cc(-n3c([S-])nnc3[C@@H](C)Cn3nc(C(F)(F)F)cc3C)cn2)cc1.,Cc1ccc(Cn2cc(-n3c([S-])nnc3[C@@H](C)Cn3nc(C(F)(F)F)cc3C)cn2)cc1,benzene_ring
+177142,Modify the molecule Cc1cc2c(N(C)CC(=O)NC(C)(C)C)ncnc2s1 by removing a amide.,Cc1cc2c(N(C)CC(=O)NC(C)(C)C)ncnc2s1,amide
+124601,Please remove a halo from the molecule C[C@@H]1CCCN(C(=O)Nc2ccc(F)c(Br)c2)[C@H]1CO.,C[C@@H]1CCCN(C(=O)Nc2ccc(F)c(Br)c2)[C@H]1CO,halo
+164508,Please remove a benzene_ring from the molecule COc1ccc(CCNc2ncnc3sc(C(=O)[O-])c(C)c23)cc1OC.,COc1ccc(CCNc2ncnc3sc(C(=O)[O-])c(C)c23)cc1OC,benzene_ring
+237961,Please remove a amide from the molecule CCN1C(=O)c2ccc(C(=O)N(C)[C@H](C)c3ccccc3)cc2S1(=O)=O.,CCN1C(=O)c2ccc(C(=O)N(C)[C@H](C)c3ccccc3)cc2S1(=O)=O,amide
+58944,Remove a amine from the molecule CCOc1ccc([C@H]2C(C#N)=C(N)Oc3cc(OC(=O)[C@@H]4COc5ccccc5O4)ccc32)cc1.,CCOc1ccc([C@H]2C(C#N)=C(N)Oc3cc(OC(=O)[C@@H]4COc5ccccc5O4)ccc32)cc1,amine
+66675,Please remove a amide from the molecule Cc1cc(C)cc(NC(=O)c2ccc(NC(=O)[C@H]3[C@@H]4C[C@@H]5OC(=O)[C@@H]3[C@@H]5C4)cc2)c1.,Cc1cc(C)cc(NC(=O)c2ccc(NC(=O)[C@H]3[C@@H]4C[C@@H]5OC(=O)[C@@H]3[C@@H]5C4)cc2)c1,amide
+42218,Remove a benzene_ring from the molecule O=S(=O)(N[C@H]1CCCc2ccccc21)c1ccc(F)cc1.,O=S(=O)(N[C@H]1CCCc2ccccc21)c1ccc(F)cc1,benzene_ring
+37390,Remove a benzene_ring from the molecule CCc1ccccc1NC(=O)Cn1c(C)nc2c(sc3nc(-c4ccccc4)ccc32)c1=O.,CCc1ccccc1NC(=O)Cn1c(C)nc2c(sc3nc(-c4ccccc4)ccc32)c1=O,benzene_ring
+201612,Modify the molecule Cc1cc(=O)n(C)cc1NC(=O)[C@H]1CCCN(C(=O)c2ccccc2)C1 by removing a benzene_ring.,Cc1cc(=O)n(C)cc1NC(=O)[C@H]1CCCN(C(=O)c2ccccc2)C1,benzene_ring
+231839,Modify the molecule CC(=O)Nc1sc2ccccc2c1Br by removing a halo.,CC(=O)Nc1sc2ccccc2c1Br,halo
+207693,Remove a benzene_ring from the molecule COc1ccccc1-c1nc(C[NH2+][C@H](C)C(C)(C)C)cs1.,COc1ccccc1-c1nc(C[NH2+][C@H](C)C(C)(C)C)cs1,benzene_ring
+83603,Please remove a halo from the molecule CCOC(=O)[C@@H]1CCCN(C(=O)Nc2ccc(OCC)c(Cl)c2)C1.,CCOC(=O)[C@@H]1CCCN(C(=O)Nc2ccc(OCC)c(Cl)c2)C1,halo
+221747,Modify the molecule NC(=O)[C@@H](CNC(=O)c1cc(F)ccc1O)Cc1ccc(F)cc1 by removing a benzene_ring.,NC(=O)[C@@H](CNC(=O)c1cc(F)ccc1O)Cc1ccc(F)cc1,benzene_ring
+152878,Modify the molecule C[C@@H](O)c1cc2cccc3c2n(c1=O)CCC3 by removing a hydroxyl.,C[C@@H](O)c1cc2cccc3c2n(c1=O)CCC3,hydroxyl
+87568,Remove a amide from the molecule CN1CCN(C(=O)c2cnn(-c3ccccc3)c2)[C@@H](c2ccccc2)C1.,CN1CCN(C(=O)c2cnn(-c3ccccc3)c2)[C@@H](c2ccccc2)C1,amide
+8009,Modify the molecule COc1ccc(Br)cc1-c1nnc2n(Cc3ccccc3)c3c(=O)n(C)c(=O)n(C)c3n12 by removing a benzene_ring.,COc1ccc(Br)cc1-c1nnc2n(Cc3ccccc3)c3c(=O)n(C)c(=O)n(C)c3n12,benzene_ring
+140113,Remove a nitro from the molecule O=C([O-])CCCC(=O)Nc1ccc([N+](=O)[O-])cc1.,O=C([O-])CCCC(=O)Nc1ccc([N+](=O)[O-])cc1,nitro
+73996,Modify the molecule Cc1ccc(C(=O)OC[C@H]2COC(C)(C)O2)c(F)c1 by removing a benzene_ring.,Cc1ccc(C(=O)OC[C@H]2COC(C)(C)O2)c(F)c1,benzene_ring
+87765,Remove a amide from the molecule CNC(=O)c1ccc(CSCc2cccc(NC(C)=O)c2)cc1.,CNC(=O)c1ccc(CSCc2cccc(NC(C)=O)c2)cc1,amide
+230370,Please remove a benzene_ring from the molecule C[C@@]1(C(=O)Nc2ccc(C#N)cc2)Oc2ccccc2NC1=O.,C[C@@]1(C(=O)Nc2ccc(C#N)cc2)Oc2ccccc2NC1=O,benzene_ring
+22736,Please remove a hydroxyl from the molecule Cc1cncc(NC(=O)C(=O)N[C@@H]2CCCC[C@H]2O)c1.,Cc1cncc(NC(=O)C(=O)N[C@@H]2CCCC[C@H]2O)c1,hydroxyl
+72565,Remove a halo from the molecule Cc1cccc2c1[nH]c1nc(SCC(=O)Nc3ccc(Cl)cc3)nnc12.,Cc1cccc2c1[nH]c1nc(SCC(=O)Nc3ccc(Cl)cc3)nnc12,halo
+206552,Remove a amide from the molecule COc1ccc(NC(=O)[C@H]2CS[C@@]3(C)CCC(=O)N23)cn1.,COc1ccc(NC(=O)[C@H]2CS[C@@]3(C)CCC(=O)N23)cn1,amide
+36286,Remove a benzene_ring from the molecule COc1cc(Br)c([C@H]2OCC[C@@H]2CO)cc1OC.,COc1cc(Br)c([C@H]2OCC[C@@H]2CO)cc1OC,benzene_ring
+125055,Remove a hydroxyl from the molecule N#Cc1ccc(N2C(=O)[C@H]3[C@@H](C2=O)[C@@H]2C=C[C@@]3(CO)O2)cc1.,N#Cc1ccc(N2C(=O)[C@H]3[C@@H](C2=O)[C@@H]2C=C[C@@]3(CO)O2)cc1,hydroxyl
+401,Modify the molecule COCCNC(=O)/C(C#N)=C/c1cccc(O)c1 by removing a amide.,COCCNC(=O)/C(C#N)=C/c1cccc(O)c1,amide
+83201,Modify the molecule CCOC(=O)c1cccc(NC[C@H](O)c2ccco2)n1 by removing a amine.,CCOC(=O)c1cccc(NC[C@H](O)c2ccco2)n1,amine
+97477,Please remove a amide from the molecule CCc1ccc(C(=O)N2CSC[C@H]2C(=O)[O-])o1.,CCc1ccc(C(=O)N2CSC[C@H]2C(=O)[O-])o1,amide
+187284,Please remove a benzene_ring from the molecule COc1ccc(C[NH+](C)Cc2nc(-c3ccc(C)s3)oc2C)cc1OC.,COc1ccc(C[NH+](C)Cc2nc(-c3ccc(C)s3)oc2C)cc1OC,benzene_ring
+179385,Please remove a halo from the molecule Cc1nn(C2CCC2)c2cc(F)ccc12.,Cc1nn(C2CCC2)c2cc(F)ccc12,halo
+211197,Modify the molecule CCSc1cncc(NCc2scnc2C)n1 by removing a amine.,CCSc1cncc(NCc2scnc2C)n1,amine
+105886,Remove a nitrile from the molecule C/C(=C\C(=O)NCc1cc(C#N)ccc1F)CCc1ccccc1.,C/C(=C\C(=O)NCc1cc(C#N)ccc1F)CCc1ccccc1,nitrile
+171750,Modify the molecule CC[C@@H]([NH2+][C@@H](C)c1nc2cc(Cl)ccc2n1C)C(=O)N1CCOCC1 by removing a halo.,CC[C@@H]([NH2+][C@@H](C)c1nc2cc(Cl)ccc2n1C)C(=O)N1CCOCC1,halo
+127760,Please remove a benzene_ring from the molecule COc1ccc(CN(C(=S)Nc2c(C)cc(C)cc2C)C2CC[NH+](C)CC2)cc1.,COc1ccc(CN(C(=S)Nc2c(C)cc(C)cc2C)C2CC[NH+](C)CC2)cc1,benzene_ring
+149781,Modify the molecule CC(C)CCC(=O)N1CCN(C(=O)N[C@@H](C)c2ccc(C#N)cc2)CC1 by removing a amide.,CC(C)CCC(=O)N1CCN(C(=O)N[C@@H](C)c2ccc(C#N)cc2)CC1,amide
+22704,Modify the molecule CN(C)C(=O)CN(C)C(=O)Cc1coc(-c2ccccc2)n1 by removing a amide.,CN(C)C(=O)CN(C)C(=O)Cc1coc(-c2ccccc2)n1,amide
+200920,Please remove a amine from the molecule Cc1c[nH+]c(NCc2ccc(C#N)cc2)nc1NCc1ccc(C#N)cc1.,Cc1c[nH+]c(NCc2ccc(C#N)cc2)nc1NCc1ccc(C#N)cc1,amine
+196344,Please remove a amine from the molecule FC(F)(F)C1(C(F)(F)F)CCN(Cc2cnn3c2NCCC3)C1.,FC(F)(F)C1(C(F)(F)F)CCN(Cc2cnn3c2NCCC3)C1,amine
+36265,Remove a benzene_ring from the molecule O=S(=O)(/C=C/c1ccc(Cl)cc1)NCc1ccc2ccccc2c1.,O=S(=O)(/C=C/c1ccc(Cl)cc1)NCc1ccc2ccccc2c1,benzene_ring
+79510,Modify the molecule Cc1ccccc1OCC(=O)O[C@H](C)C[NH+]1CCOCC1 by removing a benzene_ring.,Cc1ccccc1OCC(=O)O[C@H](C)C[NH+]1CCOCC1,benzene_ring
+226277,Please remove a hydroxyl from the molecule O=c1c2ccccc2ncn1CC(O)Cn1cnc2ccccc2c1=O.,O=c1c2ccccc2ncn1CC(O)Cn1cnc2ccccc2c1=O,hydroxyl
+4837,Remove a amide from the molecule O=C(COc1ccc([N+](=O)[O-])cc1Cl)NC1CCCCCCC1.,O=C(COc1ccc([N+](=O)[O-])cc1Cl)NC1CCCCCCC1,amide
+227713,Please remove a benzene_ring from the molecule CN(C[C@@H]1C=NN=C1c1ccccc1)C(=O)c1cccc(C#CC(C)(C)O)c1.,CN(C[C@@H]1C=NN=C1c1ccccc1)C(=O)c1cccc(C#CC(C)(C)O)c1,benzene_ring
+60773,Please remove a amide from the molecule O=C(Nc1cccnc1)c1ccccc1-c1ccccc1.,O=C(Nc1cccnc1)c1ccccc1-c1ccccc1,amide
+1550,Remove a amine from the molecule COc1ccc(N)cc1-c1ccccc1.,COc1ccc(N)cc1-c1ccccc1,amine
+22494,Remove a amide from the molecule Cc1cccc(C2=CCN(C(=O)c3cnn(C)c3-n3cccc3)CC2)c1.,Cc1cccc(C2=CCN(C(=O)c3cnn(C)c3-n3cccc3)CC2)c1,amide
+130219,Remove a halo from the molecule COCC[C@@H](C)NC(=O)Nc1cc(F)ccc1OC.,COCC[C@@H](C)NC(=O)Nc1cc(F)ccc1OC,halo
+159867,Remove a amine from the molecule CN1CCO[C@H](COc2ccc(CC(N)=S)cc2)C1.,CN1CCO[C@H](COc2ccc(CC(N)=S)cc2)C1,amine
+183153,Modify the molecule CC[C@H](Nc1nnnn1-c1ccccc1)C(=O)NC[C@@H]1CCCO1 by removing a amide.,CC[C@H](Nc1nnnn1-c1ccccc1)C(=O)NC[C@@H]1CCCO1,amide
+193899,Please remove a amide from the molecule CCC[C@H](NC(=O)CSc1nc2ccccc2n(C)c1=O)c1cccs1.,CCC[C@H](NC(=O)CSc1nc2ccccc2n(C)c1=O)c1cccs1,amide
+9240,Modify the molecule CS(=O)(=O)[C@@H]1CCC[C@@H](Nc2ncnc3[nH]cnc23)C1 by removing a amine.,CS(=O)(=O)[C@@H]1CCC[C@@H](Nc2ncnc3[nH]cnc23)C1,amine
+34972,Modify the molecule Cc1cscc1C(=O)Nc1ccc(C#CC[NH3+])cc1 by removing a benzene_ring.,Cc1cscc1C(=O)Nc1ccc(C#CC[NH3+])cc1,benzene_ring
+86098,Please remove a benzene_ring from the molecule C[C@@](N)(C(=O)OCc1ccc(Cl)cc1)C(F)(F)F.,C[C@@](N)(C(=O)OCc1ccc(Cl)cc1)C(F)(F)F,benzene_ring
+113391,Remove a benzene_ring from the molecule CCCOCC(=O)Nc1cc(C(N)=O)ccc1C.,CCCOCC(=O)Nc1cc(C(N)=O)ccc1C,benzene_ring
+220037,Modify the molecule O=C(C[NH+]1CCC[C@H](C(F)(F)F)C1)Nc1nccs1 by removing a amide.,O=C(C[NH+]1CCC[C@H](C(F)(F)F)C1)Nc1nccs1,amide
+224290,Please remove a amide from the molecule CCCCc1nc(C)c(C(=O)N(CC(N)=O)C2CCCC2)s1.,CCCCc1nc(C)c(C(=O)N(CC(N)=O)C2CCCC2)s1,amide
+195871,Remove a amine from the molecule N/N=C1\C[C@@H](c2ccccc2)Oc2ccccc21.,N/N=C1\C[C@@H](c2ccccc2)Oc2ccccc21,amine
+119328,Remove a halo from the molecule C[NH+]1[C@H]2CC[C@@H]1CN(C(=O)Nc1cc3c(cc1Cl)OCCCO3)CC2.,C[NH+]1[C@H]2CC[C@@H]1CN(C(=O)Nc1cc3c(cc1Cl)OCCCO3)CC2,halo
+104665,Please remove a amine from the molecule CC1(C)C[C@@H](Nc2cc(S(C)(=O)=O)ccc2Cl)C(C)(C)O1.,CC1(C)C[C@@H](Nc2cc(S(C)(=O)=O)ccc2Cl)C(C)(C)O1,amine
+118940,Please remove a hydroxyl from the molecule O=S(=O)(c1cccc(Br)c1)N1CCN(C[C@H](O)c2ccccc2F)CC1.,O=S(=O)(c1cccc(Br)c1)N1CCN(C[C@H](O)c2ccccc2F)CC1,hydroxyl
+94135,Modify the molecule C=C(Br)CN1CCC[C@H]1CN1CCOCC1 by removing a halo.,C=C(Br)CN1CCC[C@H]1CN1CCOCC1,halo
+9827,Please remove a benzene_ring from the molecule O=C1C[C@@H](C(=O)N2CCC[C@@H](O)C2)CN1CCc1ccccc1.,O=C1C[C@@H](C(=O)N2CCC[C@@H](O)C2)CN1CCc1ccccc1,benzene_ring
+170686,Please remove a amine from the molecule Cc1ccc(S(=O)(=O)Nc2ccc(C(=O)N(C)C)cc2)cc1[N+](=O)[O-].,Cc1ccc(S(=O)(=O)Nc2ccc(C(=O)N(C)C)cc2)cc1[N+](=O)[O-],amine
+2468,Please remove a benzene_ring from the molecule Cc1csc(N2CCCN(C(=O)[C@@H]3C[C@@H]3c3ccccc3C)CC2)n1.,Cc1csc(N2CCCN(C(=O)[C@@H]3C[C@@H]3c3ccccc3C)CC2)n1,benzene_ring
+216559,Modify the molecule COc1cccc(N2C[C@@H](C(=O)N3CCCSC[C@H]3C[NH+](C)C)CC2=O)c1 by removing a amide.,COc1cccc(N2C[C@@H](C(=O)N3CCCSC[C@H]3C[NH+](C)C)CC2=O)c1,amide
+144956,Remove a benzene_ring from the molecule C[C@@H]1CN(C(=O)NCc2ncnn2C)C[C@@H](c2ccccc2)O1.,C[C@@H]1CN(C(=O)NCc2ncnn2C)C[C@@H](c2ccccc2)O1,benzene_ring
+103069,Please remove a amide from the molecule O=C(CCC(=O)c1cccs1)N[C@H]1CCCN(Cc2ccccc2)C1=O.,O=C(CCC(=O)c1cccs1)N[C@H]1CCCN(Cc2ccccc2)C1=O,amide
+64531,Please remove a benzene_ring from the molecule COc1ccc(S(=O)(=O)N2CCc3ccccc3C2)c(Cl)c1Cl.,COc1ccc(S(=O)(=O)N2CCc3ccccc3C2)c(Cl)c1Cl,benzene_ring
+44767,Modify the molecule CCOc1ccc(/C=N/NC(=O)CNC(=O)c2ccccc2I)cc1 by removing a benzene_ring.,CCOc1ccc(/C=N/NC(=O)CNC(=O)c2ccccc2I)cc1,benzene_ring
+141568,Please remove a benzene_ring from the molecule Cc1nc(C[C@H](O)CCOc2ccccc2)sc1C.,Cc1nc(C[C@H](O)CCOc2ccccc2)sc1C,benzene_ring
+244287,Remove a amide from the molecule Cc1cc(C)n(-c2ccc(N3CCN(C(=O)c4ccc(F)cc4F)CC3)nn2)n1.,Cc1cc(C)n(-c2ccc(N3CCN(C(=O)c4ccc(F)cc4F)CC3)nn2)n1,amide
+76494,Modify the molecule c1ccc(-c2nc(SCc3cn4cccnc4n3)oc2-c2ccccc2)cc1 by removing a benzene_ring.,c1ccc(-c2nc(SCc3cn4cccnc4n3)oc2-c2ccccc2)cc1,benzene_ring
+11971,Please remove a halo from the molecule CCCNC(=O)CN1C(=O)/C(=N\NC(=O)c2ccccc2Cl)c2ccccc21.,CCCNC(=O)CN1C(=O)/C(=N\NC(=O)c2ccccc2Cl)c2ccccc21,halo
+246749,Please remove a benzene_ring from the molecule C[C@H](Cc1cccc(F)c1)C(=O)NCC(C)(C)c1ccccc1F.,C[C@H](Cc1cccc(F)c1)C(=O)NCC(C)(C)c1ccccc1F,benzene_ring
+111693,Please remove a benzene_ring from the molecule COc1cccc(C(=O)Cn2c(=O)c(C#N)cn(C3CC3)c2=O)c1.,COc1cccc(C(=O)Cn2c(=O)c(C#N)cn(C3CC3)c2=O)c1,benzene_ring
+91267,Please remove a amide from the molecule C[C@H]1CN(C(=O)/C=C/c2ccc(N3CCCC3=O)cc2)C(C)(C)CO1.,C[C@H]1CN(C(=O)/C=C/c2ccc(N3CCCC3=O)cc2)C(C)(C)CO1,amide
+240168,Remove a benzene_ring from the molecule C/[NH+]=C(/NCC(=O)Nc1ccc(F)cc1)N[C@@H]1C[C@H]1C.,C/[NH+]=C(/NCC(=O)Nc1ccc(F)cc1)N[C@@H]1C[C@H]1C,benzene_ring
+186219,Modify the molecule CCOc1cc(C(=O)NCc2cccc(OC)c2)ccc1OC by removing a benzene_ring.,CCOc1cc(C(=O)NCc2cccc(OC)c2)ccc1OC,benzene_ring
+202987,Please remove a halo from the molecule Cc1ccc(C)c(NC(=O)N[C@@H]2CC(=O)N(c3cccc(F)c3)C2)c1.,Cc1ccc(C)c(NC(=O)N[C@@H]2CC(=O)N(c3cccc(F)c3)C2)c1,halo
+156220,Please remove a amide from the molecule Cc1cc(NC(=O)c2ccc(-n3cncn3)nc2)ccc1N(C)C.,Cc1cc(NC(=O)c2ccc(-n3cncn3)nc2)ccc1N(C)C,amide
+61376,Modify the molecule Cc1nc(C)c(CNS(=O)(=O)c2ccc(F)c(C(F)(F)F)c2)s1 by removing a amine.,Cc1nc(C)c(CNS(=O)(=O)c2ccc(F)c(C(F)(F)F)c2)s1,amine
+15960,Modify the molecule CN1C(=O)N[C@@H](c2ccccc2Cl)C2=C1CN(CC(=O)NCc1ccccc1)C2=O by removing a benzene_ring.,CN1C(=O)N[C@@H](c2ccccc2Cl)C2=C1CN(CC(=O)NCc1ccccc1)C2=O,benzene_ring
+164353,Remove a halo from the molecule CCOc1nnc(CN2CCN(c3ncccc3F)CC2)s1.,CCOc1nnc(CN2CCN(c3ncccc3F)CC2)s1,halo
+51821,Remove a benzene_ring from the molecule CN(C)c1cc(C(=O)Nc2ccc([S@](C)=O)cc2)ccn1.,CN(C)c1cc(C(=O)Nc2ccc([S@](C)=O)cc2)ccn1,benzene_ring
+29411,Remove a benzene_ring from the molecule COc1cccc(CN(C)S(=O)(=O)c2ccc(C(C)C)cc2)c1.,COc1cccc(CN(C)S(=O)(=O)c2ccc(C(C)C)cc2)c1,benzene_ring
+108000,Please remove a benzene_ring from the molecule O=C(/C=C/C1CCOCC1)NC1(c2ccc(F)cc2F)CCCC1.,O=C(/C=C/C1CCOCC1)NC1(c2ccc(F)cc2F)CCCC1,benzene_ring
+199314,Please remove a benzene_ring from the molecule CC[C@@](C)([C@H](N)Cc1cccc(Br)c1)[NH+]1CCCCC1.,CC[C@@](C)([C@H](N)Cc1cccc(Br)c1)[NH+]1CCCCC1,benzene_ring
+119380,Please remove a amide from the molecule CSc1ccc2cc(CN3C(=O)N[C@](C)(c4ccco4)C3=O)c(Cl)nc2c1.,CSc1ccc2cc(CN3C(=O)N[C@](C)(c4ccco4)C3=O)c(Cl)nc2c1,amide
+23503,Modify the molecule CCCN1C(=O)c2[nH]nc(-c3cc(C)ccc3O)c2[C@@H]1c1ccc(C)cc1 by removing a amide.,CCCN1C(=O)c2[nH]nc(-c3cc(C)ccc3O)c2[C@@H]1c1ccc(C)cc1,amide
+17624,Modify the molecule CC(C)NC(=O)c1ccc(-c2nc3cc(NS(=O)(=O)Cc4cccc(F)c4)ccc3n2C)cc1 by removing a amine.,CC(C)NC(=O)c1ccc(-c2nc3cc(NS(=O)(=O)Cc4cccc(F)c4)ccc3n2C)cc1,amine
+133814,Remove a halo from the molecule Cc1cccc(OCc2nnc(SCc3cc(F)cc4cccnc34)o2)c1.,Cc1cccc(OCc2nnc(SCc3cc(F)cc4cccnc34)o2)c1,halo
+164487,Please remove a amide from the molecule CC(C)NC(=S)NC(=O)c1ccc(OC(C)C)c(Br)c1.,CC(C)NC(=S)NC(=O)c1ccc(OC(C)C)c(Br)c1,amide
+139612,Remove a amide from the molecule CCS(=O)(=O)N1CCC[C@@H](C(=O)NC2CCCCCC2)C1.,CCS(=O)(=O)N1CCC[C@@H](C(=O)NC2CCCCCC2)C1,amide
+213423,Please remove a amine from the molecule COc1ccc(NC(=S)NC(=O)c2ccccc2Br)cc1OC.,COc1ccc(NC(=S)NC(=O)c2ccccc2Br)cc1OC,amine
+236197,Please remove a amine from the molecule Cn1ccnc1Sc1ccc(N)c(N)n1.,Cn1ccnc1Sc1ccc(N)c(N)n1,amine
+189903,Remove a amine from the molecule c1cc(CCCNc2ccc(-c3nc(C4CC4)no3)c[nH+]2)ccn1.,c1cc(CCCNc2ccc(-c3nc(C4CC4)no3)c[nH+]2)ccn1,amine
+231511,Please remove a amine from the molecule N/C(=[NH+]\[N-]S(=O)(=O)c1ccccc1OC(F)(F)F)c1ccc(C(F)(F)F)cn1.,N/C(=[NH+]\[N-]S(=O)(=O)c1ccccc1OC(F)(F)F)c1ccc(C(F)(F)F)cn1,amine
+226748,Remove a nitrile from the molecule Cc1csc([C@@H](C#N)C(=O)c2ccc(F)c(F)c2)n1.,Cc1csc([C@@H](C#N)C(=O)c2ccc(F)c(F)c2)n1,nitrile
+189255,Please remove a halo from the molecule C[C@H]1CC(OCc2cc(F)cc(C#CC[NH3+])c2)C[C@H](C)C1.,C[C@H]1CC(OCc2cc(F)cc(C#CC[NH3+])c2)C[C@H](C)C1,halo
+211036,Please remove a nitrile from the molecule COc1ccccc1NC(=O)[C@H](C)Oc1ccccc1C#N.,COc1ccccc1NC(=O)[C@H](C)Oc1ccccc1C#N,nitrile
+170177,Remove a halo from the molecule Cc1cc(NC(=O)CCc2cnn(C)c2C)ncc1Br.,Cc1cc(NC(=O)CCc2cnn(C)c2C)ncc1Br,halo
+17564,Please remove a halo from the molecule Cc1cnc(C(C)(C)NC(=O)CCCOc2ccccc2Cl)s1.,Cc1cnc(C(C)(C)NC(=O)CCCOc2ccccc2Cl)s1,halo
+184207,Remove a amide from the molecule Cc1ccc(-c2cc(N)c(=O)n(CC(=O)N3[C@@H](C)CCC[C@@H]3C)n2)s1.,Cc1ccc(-c2cc(N)c(=O)n(CC(=O)N3[C@@H](C)CCC[C@@H]3C)n2)s1,amide
+242164,Remove a halo from the molecule C[C@@H](Cn1cncn1)NC(=O)Nc1cc(F)cc(N2CCCC2)c1.,C[C@@H](Cn1cncn1)NC(=O)Nc1cc(F)cc(N2CCCC2)c1,halo
+229826,Modify the molecule CC(C)CNC(=O)Nc1ncn(Cc2ccc(C#N)cc2)n1 by removing a nitrile.,CC(C)CNC(=O)Nc1ncn(Cc2ccc(C#N)cc2)n1,nitrile
+209382,Please remove a hydroxyl from the molecule CC[C@H](O)C[C@@H](Cc1ccccc1OC)C(=O)[O-].,CC[C@H](O)C[C@@H](Cc1ccccc1OC)C(=O)[O-],hydroxyl
+143109,Remove a amide from the molecule CC(C)(CNC(=O)NC[C@H]1CCN(c2ccccc2)C1)C(N)=O.,CC(C)(CNC(=O)NC[C@H]1CCN(c2ccccc2)C1)C(N)=O,amide
+172903,Remove a amide from the molecule COc1ccc(NC(=O)c2cc(C)cc(OC)c2O)c(Cl)c1.,COc1ccc(NC(=O)c2cc(C)cc(OC)c2O)c(Cl)c1,amide
+73774,Modify the molecule CCOC1CCN(C(=O)/C=C(/C)c2ccccc2OC(F)F)CC1 by removing a halo.,CCOC1CCN(C(=O)/C=C(/C)c2ccccc2OC(F)F)CC1,halo
+188219,Modify the molecule O=C([C@@H]1COc2ccc(F)cc2C1)N1CCC[C@@H]1c1ccccc1 by removing a halo.,O=C([C@@H]1COc2ccc(F)cc2C1)N1CCC[C@@H]1c1ccccc1,halo
+23100,Modify the molecule COc1cc(C)c(S(=O)(=O)N[C@@H](C#N)c2ccccc2F)cc1OC by removing a nitrile.,COc1cc(C)c(S(=O)(=O)N[C@@H](C#N)c2ccccc2F)cc1OC,nitrile
+90821,Remove a amide from the molecule NC(=O)c1cccc(OCC(=O)N[C@@H](c2ccc3c(c2)CCCC3)c2cccs2)c1.,NC(=O)c1cccc(OCC(=O)N[C@@H](c2ccc3c(c2)CCCC3)c2cccs2)c1,amide
+127089,Remove a amide from the molecule CSc1ccc(C(=O)NC[C@H]2C[C@@H](O)C[NH+]2Cc2ccccc2)cc1.,CSc1ccc(C(=O)NC[C@H]2C[C@@H](O)C[NH+]2Cc2ccccc2)cc1,amide
+80126,Please remove a benzene_ring from the molecule Cc1ccccc1C(=O)NC(=S)Nc1sc2c(c1C#N)CCCC2.,Cc1ccccc1C(=O)NC(=S)Nc1sc2c(c1C#N)CCCC2,benzene_ring
+54301,Please remove a benzene_ring from the molecule Cc1ccc(/N=C2/S[C@@H](CC(=O)Nc3ccc(C(=O)[O-])cc3)C(=O)N2C)cc1.,Cc1ccc(/N=C2/S[C@@H](CC(=O)Nc3ccc(C(=O)[O-])cc3)C(=O)N2C)cc1,benzene_ring
+187788,Please remove a amide from the molecule Cc1cc(NC(=O)[C@@H](C)N2CCO[C@H](C)C2)ccc1Br.,Cc1cc(NC(=O)[C@@H](C)N2CCO[C@H](C)C2)ccc1Br,amide
+5588,Please remove a amide from the molecule Cc1nc(COc2ccccc2)sc1C(=O)N1CCOCC1.,Cc1nc(COc2ccccc2)sc1C(=O)N1CCOCC1,amide
+36098,Modify the molecule C[C@@H](SCC1=NC(=O)C2=C(c3ccccc3)CSC2=N1)C(=O)N1CCN(c2nccs2)CC1 by removing a amide.,C[C@@H](SCC1=NC(=O)C2=C(c3ccccc3)CSC2=N1)C(=O)N1CCN(c2nccs2)CC1,amide
+229895,Remove a hydroxyl from the molecule CC[NH+](CC(=O)c1c(C)cc(C)cc1C)CC(C)(C)O.,CC[NH+](CC(=O)c1c(C)cc(C)cc1C)CC(C)(C)O,hydroxyl
+95726,Modify the molecule CC1(C)CCC[C@H]1NS(=O)(=O)c1ccc(CC(=O)[O-])cc1 by removing a benzene_ring.,CC1(C)CCC[C@H]1NS(=O)(=O)c1ccc(CC(=O)[O-])cc1,benzene_ring
+135709,Remove a hydroxyl from the molecule CC[S@@](=O)[C@H]1CCCC[C@@H]1NC(=O)NCc1ccc(OC)c(O)c1.,CC[S@@](=O)[C@H]1CCCC[C@@H]1NC(=O)NCc1ccc(OC)c(O)c1,hydroxyl
+138859,Please remove a benzene_ring from the molecule CCc1nnc(NC(=O)c2c(C)c(-c3ccccc3)nc3ccccc23)s1.,CCc1nnc(NC(=O)c2c(C)c(-c3ccccc3)nc3ccccc23)s1,benzene_ring
+189348,Modify the molecule [NH3+]C[C@H](Cc1ccccc1)Cc1cccc(O)c1 by removing a benzene_ring.,[NH3+]C[C@H](Cc1ccccc1)Cc1cccc(O)c1,benzene_ring
+248830,Remove a amide from the molecule O=C(N[C@@H]1CCCCC[C@H]1C(=O)[O-])C1CC1.,O=C(N[C@@H]1CCCCC[C@H]1C(=O)[O-])C1CC1,amide
+80131,Please remove a hydroxyl from the molecule CC(=O)N1c2ccccc2C[C@H]1C(=O)N(Cc1ccccc1)[C@@H](C)CCO.,CC(=O)N1c2ccccc2C[C@H]1C(=O)N(Cc1ccccc1)[C@@H](C)CCO,hydroxyl
+165272,Please remove a halo from the molecule COc1ccc(F)c(N[C@H](C)c2sc(C)nc2C)c1.,COc1ccc(F)c(N[C@H](C)c2sc(C)nc2C)c1,halo
+3095,Remove a nitrile from the molecule CC(C)S(=O)(=O)CC(=O)N1CCN(c2ncccc2C#N)CC1.,CC(C)S(=O)(=O)CC(=O)N1CCN(c2ncccc2C#N)CC1,nitrile
+151507,Modify the molecule C[C@H](CCNC(=O)c1cccc[n+]1[O-])c1cccc(C(F)(F)F)c1 by removing a halo.,C[C@H](CCNC(=O)c1cccc[n+]1[O-])c1cccc(C(F)(F)F)c1,halo
+175575,Modify the molecule CC(C)CNC(=O)CN1CC[NH2+]CC1 by removing a amide.,CC(C)CNC(=O)CN1CC[NH2+]CC1,amide
+48859,Modify the molecule CC(C)c1noc([C@@H]2CCC(=O)N(CCCN3CCCC3=O)C2)n1 by removing a amide.,CC(C)c1noc([C@@H]2CCC(=O)N(CCCN3CCCC3=O)C2)n1,amide
+181487,Modify the molecule Cc1ccc([C@@]2(C)NC(=O)N(Cc3cccc(F)c3)C2=O)cc1 by removing a amide.,Cc1ccc([C@@]2(C)NC(=O)N(Cc3cccc(F)c3)C2=O)cc1,amide
+25319,Modify the molecule COC(=O)[C@@H]1CN(C(=O)c2ccc(Br)s2)C[C@H]1C by removing a halo.,COC(=O)[C@@H]1CN(C(=O)c2ccc(Br)s2)C[C@H]1C,halo
+75233,Modify the molecule Cc1cc(Cl)cc(C)c1Oc1cc([C@H](C)O)ccn1 by removing a hydroxyl.,Cc1cc(Cl)cc(C)c1Oc1cc([C@H](C)O)ccn1,hydroxyl
+146025,Please remove a benzene_ring from the molecule Cc1cc(C)n(-c2cccc(NC(=O)NC3CCCCCC3)c2)n1.,Cc1cc(C)n(-c2cccc(NC(=O)NC3CCCCCC3)c2)n1,benzene_ring
+29889,Please remove a amide from the molecule Cc1ccccc1OCC(=O)Nc1cccc(C(=O)N(C)c2ccccc2)c1.,Cc1ccccc1OCC(=O)Nc1cccc(C(=O)N(C)c2ccccc2)c1,amide
+116194,Remove a amide from the molecule C[C@H]1CCN(C(=O)CCc2nc(-c3ncccn3)no2)[C@H](C)C1.,C[C@H]1CCN(C(=O)CCc2nc(-c3ncccn3)no2)[C@H](C)C1,amide
+199131,Modify the molecule Cn1cnc(CNC(=O)[C@@H](OC(C)(C)C)c2ccccc2)n1 by removing a benzene_ring.,Cn1cnc(CNC(=O)[C@@H](OC(C)(C)C)c2ccccc2)n1,benzene_ring
+146330,Modify the molecule C[C@H](CC(=O)[O-])N1C(=O)S/C(=C\c2ccc(Cl)cc2)C1=O by removing a benzene_ring.,C[C@H](CC(=O)[O-])N1C(=O)S/C(=C\c2ccc(Cl)cc2)C1=O,benzene_ring
+62490,Modify the molecule [NH3+][C@@H](c1cc(F)cc(Br)c1)[C@H]1CCOC2(CCOCC2)C1 by removing a benzene_ring.,[NH3+][C@@H](c1cc(F)cc(Br)c1)[C@H]1CCOC2(CCOCC2)C1,benzene_ring
+15490,Please remove a amide from the molecule CC(C)C(=O)N1CCc2c(c(C(=O)N3CCC(C(=O)NC4CCCCCC4)CC3)nn2C)C1.,CC(C)C(=O)N1CCc2c(c(C(=O)N3CCC(C(=O)NC4CCCCCC4)CC3)nn2C)C1,amide
+188195,Please remove a benzene_ring from the molecule COC[C@@H](NCc1ccc(OC)c(C#N)c1)c1ccc(F)c(F)c1.,COC[C@@H](NCc1ccc(OC)c(C#N)c1)c1ccc(F)c(F)c1,benzene_ring
+208264,Please remove a amide from the molecule CC[C@H](C(=O)NCc1cc(-c2ccccc2)on1)c1ccccc1.,CC[C@H](C(=O)NCc1cc(-c2ccccc2)on1)c1ccccc1,amide
+145414,Please remove a halo from the molecule COc1ccc([C@H](CNS(=O)(=O)c2ccc(C)cc2Cl)N2CCOCC2)cc1.,COc1ccc([C@H](CNS(=O)(=O)c2ccc(C)cc2Cl)N2CCOCC2)cc1,halo
+71679,Please remove a amide from the molecule CCc1nnc(S[C@@H](CC)C(=O)NCc2ccco2)c2cc3occc3n12.,CCc1nnc(S[C@@H](CC)C(=O)NCc2ccco2)c2cc3occc3n12,amide
+213878,Modify the molecule CNC(=O)[C@@H](C)Oc1ccc(C[NH2+]C2CC2)cc1 by removing a amide.,CNC(=O)[C@@H](C)Oc1ccc(C[NH2+]C2CC2)cc1,amide
+59275,Remove a halo from the molecule CC1=C/C(=N\OC(=O)c2ccccc2Cl)C(C(C)C)=CC1=O.,CC1=C/C(=N\OC(=O)c2ccccc2Cl)C(C(C)C)=CC1=O,halo
+84342,Please remove a benzene_ring from the molecule Cc1ccc(C)c(OC2CCN(Cc3scnc3C)CC2)c1.,Cc1ccc(C)c(OC2CCN(Cc3scnc3C)CC2)c1,benzene_ring
+90011,Remove a benzene_ring from the molecule Cc1ccccc1NC(=O)N(C1CC1)[C@@H](C)c1ccco1.,Cc1ccccc1NC(=O)N(C1CC1)[C@@H](C)c1ccco1,benzene_ring
+244338,Remove a halo from the molecule C[C@H](OCC(F)(F)F)C(=O)N1CCC(c2ccc(F)cc2)CC1.,C[C@H](OCC(F)(F)F)C(=O)N1CCC(c2ccc(F)cc2)CC1,halo
+108614,Please remove a benzene_ring from the molecule C[C@@H]1C[C@@H](C)C[NH+](Cc2ccccc2CNC(=O)N2CCO[C@H](C)C2)C1.,C[C@@H]1C[C@@H](C)C[NH+](Cc2ccccc2CNC(=O)N2CCO[C@H](C)C2)C1,benzene_ring
+216748,Modify the molecule CC(C)Cc1ccc(-c2ccc(N)cc2)cc1 by removing a amine.,CC(C)Cc1ccc(-c2ccc(N)cc2)cc1,amine
+79908,Modify the molecule O=C(CSc1cc(N2CCCC2)ncn1)Nc1cccc(Cl)c1 by removing a amide.,O=C(CSc1cc(N2CCCC2)ncn1)Nc1cccc(Cl)c1,amide
+215264,Remove a amide from the molecule CC(=O)c1c(C)[nH]c(C(=O)NC2CCC(O)CC2)c1C.,CC(=O)c1c(C)[nH]c(C(=O)NC2CCC(O)CC2)c1C,amide
+114102,Modify the molecule CC[C@@H]([NH2+][C@@H](COC)c1ccc(F)c(F)c1)c1cnn(C)c1 by removing a benzene_ring.,CC[C@@H]([NH2+][C@@H](COC)c1ccc(F)c(F)c1)c1cnn(C)c1,benzene_ring
+94699,Remove a halo from the molecule Cc1ccc(NC(=O)[C@H](C)S(=O)(=O)Cc2c(C)nn(C)c2Cl)cc1C.,Cc1ccc(NC(=O)[C@H](C)S(=O)(=O)Cc2c(C)nn(C)c2Cl)cc1C,halo
+185291,Modify the molecule C[C@@H]1[NH2+]CCC[C@@H]1C(=O)Nc1ccc(CCO)cc1 by removing a benzene_ring.,C[C@@H]1[NH2+]CCC[C@@H]1C(=O)Nc1ccc(CCO)cc1,benzene_ring
+142664,Please remove a benzene_ring from the molecule N#Cc1ccccc1/C([O-])=N/S(=O)(=O)N1CCc2ccccc2C1.,N#Cc1ccccc1/C([O-])=N/S(=O)(=O)N1CCc2ccccc2C1,benzene_ring
+220183,Modify the molecule Cc1ccc(NC(=O)NC[C@@H](C)Oc2ccccc2F)s1 by removing a benzene_ring.,Cc1ccc(NC(=O)NC[C@@H](C)Oc2ccccc2F)s1,benzene_ring
+12362,Remove a benzene_ring from the molecule C[C@H]1CC(C(=O)NCc2ccc(OCc3ccccn3)cc2)C[C@H](C)O1.,C[C@H]1CC(C(=O)NCc2ccc(OCc3ccccn3)cc2)C[C@H](C)O1,benzene_ring
+12371,Remove a halo from the molecule COc1ccc(-c2cnc(SCC(=O)Nc3ccc(F)c(F)c3)n2C)cc1.,COc1ccc(-c2cnc(SCC(=O)Nc3ccc(F)c(F)c3)n2C)cc1,halo
+121697,Remove a amide from the molecule Cc1ccc(CC(=O)N2CCC[C@H]2Cn2nc(C)cc2C)cn1.,Cc1ccc(CC(=O)N2CCC[C@H]2Cn2nc(C)cc2C)cn1,amide
+155595,Modify the molecule N#C[C@@H]1CN([C@H]2CCN(CC(F)(F)F)C2=O)CCO1 by removing a halo.,N#C[C@@H]1CN([C@H]2CCN(CC(F)(F)F)C2=O)CCO1,halo
+93279,Modify the molecule Cc1nc(CNc2nc(-c3ccccn3)nc3c2CC[NH+](C)CC3)n[nH]1 by removing a amine.,Cc1nc(CNc2nc(-c3ccccn3)nc3c2CC[NH+](C)CC3)n[nH]1,amine
+132771,Modify the molecule COc1ccc(/N=N/c2cc(C)ccc2O)cc1 by removing a benzene_ring.,COc1ccc(/N=N/c2cc(C)ccc2O)cc1,benzene_ring
+117253,Please remove a nitro from the molecule N[C@H]1CCCn2c1nc1cc([N+](=O)[O-])ccc1c2=O.,N[C@H]1CCCn2c1nc1cc([N+](=O)[O-])ccc1c2=O,nitro
+21457,Modify the molecule CSc1ccc(Cl)c(C(=O)OCc2ccc(Cl)nc2)c1 by removing a halo.,CSc1ccc(Cl)c(C(=O)OCc2ccc(Cl)nc2)c1,halo
+139363,Please remove a halo from the molecule CC[C@@H](NC(=O)CSc1nnnn1C)c1cc(F)ccc1F.,CC[C@@H](NC(=O)CSc1nnnn1C)c1cc(F)ccc1F,halo
+195140,Please remove a amide from the molecule C[C@H](NC(=O)c1cc(-c2cccs2)nc2ccccc12)[C@@H](C)N1CCOCC1.,C[C@H](NC(=O)c1cc(-c2cccs2)nc2ccccc12)[C@@H](C)N1CCOCC1,amide
+76192,Modify the molecule CNC(=O)NCC(=O)N1CC[NH+](C2CCC(C)CC2)CC1 by removing a amide.,CNC(=O)NCC(=O)N1CC[NH+](C2CCC(C)CC2)CC1,amide
+164455,Modify the molecule Oc1ccc(C[NH+]2CCC[C@H]2C[C@@H](O)c2ccco2)c(O)c1 by removing a benzene_ring.,Oc1ccc(C[NH+]2CCC[C@H]2C[C@@H](O)c2ccco2)c(O)c1,benzene_ring
+11633,Modify the molecule CC1=[N+]2C(=N)/C(=C/c3ccc(-c4cc([N+](=O)[O-])ccc4C)o3)C(=O)N=C2SC1 by removing a nitro.,CC1=[N+]2C(=N)/C(=C/c3ccc(-c4cc([N+](=O)[O-])ccc4C)o3)C(=O)N=C2SC1,nitro
+122788,Modify the molecule Cc1ccc([N+](=O)[O-])c(NC(=O)[C@@H](C)[NH+]2CCCCCC2)c1C by removing a benzene_ring.,Cc1ccc([N+](=O)[O-])c(NC(=O)[C@@H](C)[NH+]2CCCCCC2)c1C,benzene_ring
+209514,Remove a amine from the molecule COc1cc(OC)cc(-c2cc(N)n(S(=O)(=O)c3ccc(OC)c(OC)c3)n2)c1.,COc1cc(OC)cc(-c2cc(N)n(S(=O)(=O)c3ccc(OC)c(OC)c3)n2)c1,amine
+60066,Remove a hydroxyl from the molecule Cc1cc([C@@H]2NC(=O)NC2=N)cc(C)c1O.,Cc1cc([C@@H]2NC(=O)NC2=N)cc(C)c1O,hydroxyl
+248049,Modify the molecule O=C(Cc1ccc(S(=O)(=O)N2CCCC2)s1)N1CCC[C@H](O)C1 by removing a amide.,O=C(Cc1ccc(S(=O)(=O)N2CCCC2)s1)N1CCC[C@H](O)C1,amide
+116620,Remove a hydroxyl from the molecule Cc1csc(Cn2ccc([C@@H](O)C(C)C)c2)n1.,Cc1csc(Cn2ccc([C@@H](O)C(C)C)c2)n1,hydroxyl
+117401,Please remove a amide from the molecule CCn1nc(C(=O)N2CCC(C(N)=O)CC2)ccc1=O.,CCn1nc(C(=O)N2CCC(C(N)=O)CC2)ccc1=O,amide
+194065,Modify the molecule C[NH2+][C@@H]1[C@H](C[NH+](C)C[C@@H](C)O)CCC1(C)C by removing a hydroxyl.,C[NH2+][C@@H]1[C@H](C[NH+](C)C[C@@H](C)O)CCC1(C)C,hydroxyl
+175427,Modify the molecule CCC[NH2+][C@@H](C)c1cccc(O[C@@H]2CCCCNC2=O)c1 by removing a amide.,CCC[NH2+][C@@H](C)c1cccc(O[C@@H]2CCCCNC2=O)c1,amide
+11014,Modify the molecule COc1ccc(/C=N/NC(=O)c2ccc(NC(=O)c3ccccc3Cl)cc2)cc1 by removing a benzene_ring.,COc1ccc(/C=N/NC(=O)c2ccc(NC(=O)c3ccccc3Cl)cc2)cc1,benzene_ring
+52268,Remove a amide from the molecule C[C@@H](C(=O)NC1CCCCC1)[S@@](=O)Cc1nnnn1C1CC1.,C[C@@H](C(=O)NC1CCCCC1)[S@@](=O)Cc1nnnn1C1CC1,amide
+151283,Please remove a amide from the molecule CN(Cc1ccccc1)C(=O)CN(c1cccc(Cl)c1Cl)S(=O)(=O)c1ccccc1.,CN(Cc1ccccc1)C(=O)CN(c1cccc(Cl)c1Cl)S(=O)(=O)c1ccccc1,amide
+172431,Please remove a amide from the molecule O=C(/C=C/c1ccco1)Nc1ccc(NC(=O)c2ccco2)cc1.,O=C(/C=C/c1ccco1)Nc1ccc(NC(=O)c2ccco2)cc1,amide
+111261,Remove a amide from the molecule Cc1nn(Cc2ccccc2)c(C)c1CNc1cncc(C(N)=O)n1.,Cc1nn(Cc2ccccc2)c(C)c1CNc1cncc(C(N)=O)n1,amide
+202606,Remove a halo from the molecule O=[N+]([O-])c1cc(Br)ccc1N1CC[C@H](O)C1.,O=[N+]([O-])c1cc(Br)ccc1N1CC[C@H](O)C1,halo
+160909,Please remove a amide from the molecule CN1C(=O)C([C@@H]2c3c(n(C)c(=O)n(C)c3=O)Oc3ccc4ccccc4c32)C(=O)N(C)C1=O.,CN1C(=O)C([C@@H]2c3c(n(C)c(=O)n(C)c3=O)Oc3ccc4ccccc4c32)C(=O)N(C)C1=O,amide
+119368,Please remove a amide from the molecule Cc1noc(COCC(=O)N2CCSC[C@@H]2c2ccc(C)o2)n1.,Cc1noc(COCC(=O)N2CCSC[C@@H]2c2ccc(C)o2)n1,amide
+52925,Please remove a benzene_ring from the molecule Cc1ccc(N/C(=N/C(=O)c2ccc(C)cc2)NC[C@@H]2CCCO2)cc1.,Cc1ccc(N/C(=N/C(=O)c2ccc(C)cc2)NC[C@@H]2CCCO2)cc1,benzene_ring
+237254,Please remove a amide from the molecule O=C1CC[C@@]2(CCCN(C(=O)c3c[nH]c(=O)cn3)C2)CN1Cc1cccnc1.,O=C1CC[C@@]2(CCCN(C(=O)c3c[nH]c(=O)cn3)C2)CN1Cc1cccnc1,amide
+67026,Please remove a benzene_ring from the molecule Cc1ccc(-c2noc(C[S@@](=O)[C@H](C)c3ccccc3)n2)cc1F.,Cc1ccc(-c2noc(C[S@@](=O)[C@H](C)c3ccccc3)n2)cc1F,benzene_ring
+79148,Modify the molecule CC(C)Oc1ncnc(N(C)[C@H]2CCS(=O)(=O)C2)c1N by removing a amine.,CC(C)Oc1ncnc(N(C)[C@H]2CCS(=O)(=O)C2)c1N,amine
+134302,Please remove a halo from the molecule CC[C@@H](C)n1c([C@@H]2CCC[NH2+]2)nc2cc(C(F)(F)F)ccc21.,CC[C@@H](C)n1c([C@@H]2CCC[NH2+]2)nc2cc(C(F)(F)F)ccc21,halo
+245164,Modify the molecule N#Cc1cc(S(N)(=O)=O)ccc1NC[C@@H]1CCC[C@@H]1O by removing a hydroxyl.,N#Cc1cc(S(N)(=O)=O)ccc1NC[C@@H]1CCC[C@@H]1O,hydroxyl
+72817,Modify the molecule C[C@H](NC(=O)c1cccc(C(N)=O)c1)C(c1ccccc1)c1ccccc1 by removing a benzene_ring.,C[C@H](NC(=O)c1cccc(C(N)=O)c1)C(c1ccccc1)c1ccccc1,benzene_ring
+201411,Modify the molecule O=C(Cc1ccon1)N[C@H](c1ccc(F)cc1)[C@H]1CCCO1 by removing a benzene_ring.,O=C(Cc1ccon1)N[C@H](c1ccc(F)cc1)[C@H]1CCCO1,benzene_ring
+160269,Please remove a benzene_ring from the molecule CCOC(=O)c1cnc2nc(C)ccc2c1Nc1ccc(S(N)(=O)=O)cc1.,CCOC(=O)c1cnc2nc(C)ccc2c1Nc1ccc(S(N)(=O)=O)cc1,benzene_ring
+235514,Modify the molecule CN1C(=O)C(=Cc2c(N3CCCCC3)nc3ccccn3c2=O)C(=O)N(C)C1=O by removing a amide.,CN1C(=O)C(=Cc2c(N3CCCCC3)nc3ccccn3c2=O)C(=O)N(C)C1=O,amide
+17035,Please remove a amide from the molecule CC(C)(C)NC(=O)N1CC[C@@]2(C1)C(=O)Nc1ccccc12.,CC(C)(C)NC(=O)N1CC[C@@]2(C1)C(=O)Nc1ccccc12,amide
+76762,Please remove a benzene_ring from the molecule CC1(C)CC(=O)C2=C(C1)OC(/N=C/N1CCCC1)=C(C#N)[C@H]2c1ccccc1.,CC1(C)CC(=O)C2=C(C1)OC(/N=C/N1CCCC1)=C(C#N)[C@H]2c1ccccc1,benzene_ring
+136540,Modify the molecule Cc1cc(Sc2nncn2C)ncc1N by removing a amine.,Cc1cc(Sc2nncn2C)ncc1N,amine
+6203,Please remove a halo from the molecule O=C(CCC(=O)N1CCN(c2ccccc2F)CC1)c1ccc(Cl)s1.,O=C(CCC(=O)N1CCN(c2ccccc2F)CC1)c1ccc(Cl)s1,halo
+44341,Please remove a amide from the molecule CC1=C(C)C[C@H]2C(=O)N(c3ccccc3C)C(=O)[C@H]2C1.,CC1=C(C)C[C@H]2C(=O)N(c3ccccc3C)C(=O)[C@H]2C1,amide
+211331,Please remove a amide from the molecule COC(=O)c1ccsc1NC(=O)c1ccsc1NC(=O)c1cccs1.,COC(=O)c1ccsc1NC(=O)c1ccsc1NC(=O)c1cccs1,amide
+1814,Modify the molecule Cc1ccccc1N1CCN(C(=O)[C@@]23CC[C@@H](C[C@@H]2Br)C3)CC1 by removing a amide.,Cc1ccccc1N1CCN(C(=O)[C@@]23CC[C@@H](C[C@@H]2Br)C3)CC1,amide
+235828,Please remove a nitrile from the molecule COc1ccc(C(=O)c2c(C)c(C#N)c(=O)n([C@@H](C)c3ccccc3)c2[O-])cc1.,COc1ccc(C(=O)c2c(C)c(C#N)c(=O)n([C@@H](C)c3ccccc3)c2[O-])cc1,nitrile
+224397,Remove a halo from the molecule CC(=O)N1CCCN(C(=O)C(=O)Nc2cccc(Cl)c2Cl)CC1.,CC(=O)N1CCCN(C(=O)C(=O)Nc2cccc(Cl)c2Cl)CC1,halo
+172210,Remove a halo from the molecule CCCCN(C)C(=O)N[C@H]1CCCc2ccc(F)cc21.,CCCCN(C)C(=O)N[C@H]1CCCc2ccc(F)cc21,halo
+40891,Remove a benzene_ring from the molecule Cc1ccc(C(C)(C)C(=O)O[C@H](C)c2ccccn2)cc1.,Cc1ccc(C(C)(C)C(=O)O[C@H](C)c2ccccn2)cc1,benzene_ring
+25218,Modify the molecule CCc1ccc(N(C(C)=O)c2nc(CSc3nnc(C(F)(F)F)n3N)cs2)cc1 by removing a halo.,CCc1ccc(N(C(C)=O)c2nc(CSc3nnc(C(F)(F)F)n3N)cs2)cc1,halo
+207471,Please remove a halo from the molecule O=S(=O)([N-]c1nc2ccccc2nc1Cl)c1ccc2ccccc2c1.,O=S(=O)([N-]c1nc2ccccc2nc1Cl)c1ccc2ccccc2c1,halo
+168980,Modify the molecule CCSc1nc(CC(=O)N2CCC3(CC2)OCCC[C@@H]3OC)cs1 by removing a amide.,CCSc1nc(CC(=O)N2CCC3(CC2)OCCC[C@@H]3OC)cs1,amide
+130573,Modify the molecule C[C@@H]1CC(C)(C)C[C@@]2(C1)NC(=O)N(CN1CCc3sccc3C1)C2=O by removing a amide.,C[C@@H]1CC(C)(C)C[C@@]2(C1)NC(=O)N(CN1CCc3sccc3C1)C2=O,amide
+20167,Remove a benzene_ring from the molecule NC(=O)[C@@H]1CCC[NH+]1[C@H](C(=O)[O-])c1c[nH]c2cc(NC(=O)c3ccccc3)ccc12.,NC(=O)[C@@H]1CCC[NH+]1[C@H](C(=O)[O-])c1c[nH]c2cc(NC(=O)c3ccccc3)ccc12,benzene_ring
+125620,Remove a amide from the molecule CCn1cc(CN2CCO[C@H](c3cc(C(=O)NCC(C)C)c4ccccc4n3)C2)cn1.,CCn1cc(CN2CCO[C@H](c3cc(C(=O)NCC(C)C)c4ccccc4n3)C2)cn1,amide
+168709,Modify the molecule CC1=NN2C(=N)/C(=C\c3cc(C)n(-c4ccc(Cl)cc4)c3C)C(=O)N=C2S1 by removing a halo.,CC1=NN2C(=N)/C(=C\c3cc(C)n(-c4ccc(Cl)cc4)c3C)C(=O)N=C2S1,halo
+211104,Remove a nitrile from the molecule N#CCc1nc2cc(C(F)(F)F)c(C#N)cc2s1.,N#CCc1nc2cc(C(F)(F)F)c(C#N)cc2s1,nitrile
+131676,Remove a amine from the molecule CCc1nn(C)c(OC)c1CN[C@H](C)c1ccnc(Cl)c1.,CCc1nn(C)c(OC)c1CN[C@H](C)c1ccnc(Cl)c1,amine
+140159,Modify the molecule COc1ccc2c(c1)[C@H](O)[C@@H]([NH+]1CCCC(C)(C)C1)CC2 by removing a hydroxyl.,COc1ccc2c(c1)[C@H](O)[C@@H]([NH+]1CCCC(C)(C)C1)CC2,hydroxyl
+20890,Modify the molecule COC(=O)c1ccc(C[NH2+][C@@H]2CCCC[C@H]2C(F)(F)F)[nH]1 by removing a halo.,COC(=O)c1ccc(C[NH2+][C@@H]2CCCC[C@H]2C(F)(F)F)[nH]1,halo
+100634,Modify the molecule CCCCc1ccc(NC(=O)NCc2n[nH]c(=S)n2C(C)C)cc1 by removing a benzene_ring.,CCCCc1ccc(NC(=O)NCc2n[nH]c(=S)n2C(C)C)cc1,benzene_ring
+182021,Modify the molecule N#Cc1cccc(C(=O)N2CCN(Cc3noc(-c4cccc(Cl)c4)n3)CC2)c1 by removing a amide.,N#Cc1cccc(C(=O)N2CCN(Cc3noc(-c4cccc(Cl)c4)n3)CC2)c1,amide
+141700,Please remove a amide from the molecule O=C(N[C@H]1CCOc2ccccc21)c1cnc([C@@H]2CCCO2)s1.,O=C(N[C@H]1CCOc2ccccc21)c1cnc([C@@H]2CCCO2)s1,amide
+31522,Modify the molecule Cc1cc(N2CCCC[C@@H]2C)n2nc(-c3ccccc3C)nc2n1 by removing a benzene_ring.,Cc1cc(N2CCCC[C@@H]2C)n2nc(-c3ccccc3C)nc2n1,benzene_ring
+155577,Remove a amide from the molecule CCNC(=O)c1ccc(N(CCC[NH3+])C2CC2)[nH+]n1.,CCNC(=O)c1ccc(N(CCC[NH3+])C2CC2)[nH+]n1,amide
+125064,Remove a benzene_ring from the molecule CCn1c(=O)c2c(nc3n(-c4ccc(C)c(C)c4)c(C)cn23)n(C)c1=O.,CCn1c(=O)c2c(nc3n(-c4ccc(C)c(C)c4)c(C)cn23)n(C)c1=O,benzene_ring
+4641,Modify the molecule CN(CC1CC[NH+](C)CC1)[C@@H](C[NH3+])c1cc(Cl)cs1 by removing a halo.,CN(CC1CC[NH+](C)CC1)[C@@H](C[NH3+])c1cc(Cl)cs1,halo
+192817,Please remove a amine from the molecule O=C([O-])c1ccc2c(c1)[N-]C1=NS(=O)(=O)N=C1N2.,O=C([O-])c1ccc2c(c1)[N-]C1=NS(=O)(=O)N=C1N2,amine
+37626,Modify the molecule CC(C)n1c(S[C@@H](C)C(=O)NC2CC2)nnc1N(C)C by removing a amide.,CC(C)n1c(S[C@@H](C)C(=O)NC2CC2)nnc1N(C)C,amide
+150207,Remove a amide from the molecule CCS(=O)(=O)c1cccc(C(=O)N(Cc2ccncc2)c2nc3cc(OC)ccc3s2)c1.,CCS(=O)(=O)c1cccc(C(=O)N(Cc2ccncc2)c2nc3cc(OC)ccc3s2)c1,amide
+109777,Remove a benzene_ring from the molecule N#C/C(=C\c1ccco1)C(=O)Nc1ncc(Cc2ccc(F)cc2)s1.,N#C/C(=C\c1ccco1)C(=O)Nc1ncc(Cc2ccc(F)cc2)s1,benzene_ring
+6034,Modify the molecule CC(C)CNC(=O)C[NH2+]C1C(C)(C)C1(C)C by removing a amide.,CC(C)CNC(=O)C[NH2+]C1C(C)(C)C1(C)C,amide
+146076,Remove a hydroxyl from the molecule CCc1ccc([C@@H](O)[C@]2(C)CCCO2)s1.,CCc1ccc([C@@H](O)[C@]2(C)CCCO2)s1,hydroxyl
+120971,Modify the molecule Cc1cc(CC(=O)N(Cc2ccc(C)o2)c2ccc(F)cc2)no1 by removing a benzene_ring.,Cc1cc(CC(=O)N(Cc2ccc(C)o2)c2ccc(F)cc2)no1,benzene_ring
+106244,Please remove a amide from the molecule CO[C@@H]1C=C[C@@](CNC(=O)[C@@H]2CCCN(c3cc(-n4cccn4)ncn3)C2)(OC)O1.,CO[C@@H]1C=C[C@@](CNC(=O)[C@@H]2CCCN(c3cc(-n4cccn4)ncn3)C2)(OC)O1,amide
+96704,Modify the molecule COc1ccc(Nc2nnc(S[C@H]3CC(=O)N(c4cccc(Cl)c4C)C3=O)s2)cc1 by removing a amine.,COc1ccc(Nc2nnc(S[C@H]3CC(=O)N(c4cccc(Cl)c4C)C3=O)s2)cc1,amine
+9717,Please remove a halo from the molecule O=C(Nc1ccccc1F)c1ccc(S(=O)(=O)N[C@H]2CC[NH2+]C2)cc1.,O=C(Nc1ccccc1F)c1ccc(S(=O)(=O)N[C@H]2CC[NH2+]C2)cc1,halo
+197671,Please remove a halo from the molecule CC[NH2+]C[C@@H](Cc1ccc(F)cc1)c1ccccc1F.,CC[NH2+]C[C@@H](Cc1ccc(F)cc1)c1ccccc1F,halo
+206885,Please remove a nitro from the molecule Cc1c(NC(=O)[C@@H](C)Sc2nncs2)cccc1[N+](=O)[O-].,Cc1c(NC(=O)[C@@H](C)Sc2nncs2)cccc1[N+](=O)[O-],nitro
+78436,Please remove a benzene_ring from the molecule CC[C@@H](C)N(C)C(=O)NCCc1csc(-c2ccccc2)n1.,CC[C@@H](C)N(C)C(=O)NCCc1csc(-c2ccccc2)n1,benzene_ring
+134400,Remove a benzene_ring from the molecule CC(C)(C)c1nc(CCNC(=O)c2c(O)cccc2O)cs1.,CC(C)(C)c1nc(CCNC(=O)c2c(O)cccc2O)cs1,benzene_ring
+111781,Remove a halo from the molecule Cc1ccc(F)cc1[C@@]1(O)CCCC1(C)C.,Cc1ccc(F)cc1[C@@]1(O)CCCC1(C)C,halo
+180139,Modify the molecule COc1ccc(-c2nc(NC(=O)C3CCN(c4cnccn4)CC3)sc2C)cc1 by removing a amide.,COc1ccc(-c2nc(NC(=O)C3CCN(c4cnccn4)CC3)sc2C)cc1,amide
+49291,Remove a amine from the molecule O=S(=O)(NCc1nnnn1-c1ccc(F)c(F)c1)c1cccc(C(F)(F)F)c1.,O=S(=O)(NCc1nnnn1-c1ccc(F)c(F)c1)c1cccc(C(F)(F)F)c1,amine
+78788,Please remove a nitro from the molecule COc1cccc([C@@H](CNC(=O)Nc2ccc([N+](=O)[O-])cc2)[NH+](C)C)c1.,COc1cccc([C@@H](CNC(=O)Nc2ccc([N+](=O)[O-])cc2)[NH+](C)C)c1,nitro
+84062,Please remove a amide from the molecule CC(C)n1nccc1NC(=O)C(=O)N[C@@H]1CCCC[C@H]1OC1CCCC1.,CC(C)n1nccc1NC(=O)C(=O)N[C@@H]1CCCC[C@H]1OC1CCCC1,amide
+147768,Modify the molecule CC(C)[NH+](Cc1ccc([N+](=O)[O-])cc1)CC1CC[NH2+]CC1 by removing a benzene_ring.,CC(C)[NH+](Cc1ccc([N+](=O)[O-])cc1)CC1CC[NH2+]CC1,benzene_ring
+95180,Remove a benzene_ring from the molecule Cc1cc(F)c([C@@H]2C[S@@](=O)CC(C)(C)N2)cc1F.,Cc1cc(F)c([C@@H]2C[S@@](=O)CC(C)(C)N2)cc1F,benzene_ring
+24980,Modify the molecule CCCN[C@@H](Cc1ccccc1Cl)C[NH+](C)C by removing a benzene_ring.,CCCN[C@@H](Cc1ccccc1Cl)C[NH+](C)C,benzene_ring
+73090,Modify the molecule CC(C)(C)c1ccc(C(=O)Nc2ccccc2N2CCNC(=O)C2)cc1 by removing a amide.,CC(C)(C)c1ccc(C(=O)Nc2ccccc2N2CCNC(=O)C2)cc1,amide
+66957,Please remove a halo from the molecule Cc1sc(C[NH3+])nc1-c1ccc(Cl)cc1Cl.,Cc1sc(C[NH3+])nc1-c1ccc(Cl)cc1Cl,halo
+68750,Remove a amide from the molecule CC[C@H]1CCCCN1C(=O)[C@H](C)OC(=O)c1ccc2nc(C)c(C)nc2c1.,CC[C@H]1CCCCN1C(=O)[C@H](C)OC(=O)c1ccc2nc(C)c(C)nc2c1,amide
+68112,Please remove a amine from the molecule CC(C)(C)C(=O)NC(=S)Nc1cccc(C(=O)N2CCCCC2)c1.,CC(C)(C)C(=O)NC(=S)Nc1cccc(C(=O)N2CCCCC2)c1,amine
+131032,Please remove a amide from the molecule Cc1n[nH]c2ncc(C(=O)Nc3nnc(C4CC4)s3)cc12.,Cc1n[nH]c2ncc(C(=O)Nc3nnc(C4CC4)s3)cc12,amide
+88178,Modify the molecule C[C@@H](NC(=O)Cn1c(C2CCCCC2)nc2ccccc21)C(N)=O by removing a amide.,C[C@@H](NC(=O)Cn1c(C2CCCCC2)nc2ccccc21)C(N)=O,amide
+190959,Please remove a amide from the molecule Cc1n[nH]cc1CNC(=O)c1ccncc1C#CC[NH3+].,Cc1n[nH]cc1CNC(=O)c1ccncc1C#CC[NH3+],amide
+5163,Remove a amide from the molecule CCO[C@@H]1C[C@H]1C(=O)N1CCC(n2c(=O)[nH]c3ccccc32)CC1.,CCO[C@@H]1C[C@H]1C(=O)N1CCC(n2c(=O)[nH]c3ccccc32)CC1,amide
+196221,Please remove a benzene_ring from the molecule CSCC[C@@H](NC(=O)c1ccccc1Cl)C(=O)N[C@@]1(C)CCS(=O)(=O)C1.,CSCC[C@@H](NC(=O)c1ccccc1Cl)C(=O)N[C@@]1(C)CCS(=O)(=O)C1,benzene_ring
+138474,Please remove a amide from the molecule Cc1ccc(O[C@H](C)C(=O)N/N=C/c2cccnc2)cc1.,Cc1ccc(O[C@H](C)C(=O)N/N=C/c2cccnc2)cc1,amide
+19015,Please remove a halo from the molecule CCCc1ccc(C(=O)Cn2ncc(Cl)c(Cl)c2=O)cc1.,CCCc1ccc(C(=O)Cn2ncc(Cl)c(Cl)c2=O)cc1,halo
+180868,Remove a benzene_ring from the molecule Cc1oc(-c2ccc(C(=O)NC3CCCC3)cc2)nc1C[S@@](=O)c1ccccc1.,Cc1oc(-c2ccc(C(=O)NC3CCCC3)cc2)nc1C[S@@](=O)c1ccccc1,benzene_ring
+94544,Remove a amide from the molecule NC(=O)NC(=O)CSc1ncnc2sc3c(c12)CCCC3.,NC(=O)NC(=O)CSc1ncnc2sc3c(c12)CCCC3,amide
+240671,Please remove a benzene_ring from the molecule C[C@H](Sc1ccccc1)c1nc(-c2cnccn2)no1.,C[C@H](Sc1ccccc1)c1nc(-c2cnccn2)no1,benzene_ring
+188102,Modify the molecule CCOc1cccc(C(=O)Nc2nc(-c3ccccc3)ns2)c1 by removing a amide.,CCOc1cccc(C(=O)Nc2nc(-c3ccccc3)ns2)c1,amide
+216569,Please remove a benzene_ring from the molecule CC(C)n1nccc1NC(=O)COc1cc(F)ccc1F.,CC(C)n1nccc1NC(=O)COc1cc(F)ccc1F,benzene_ring
+176195,Remove a benzene_ring from the molecule CCOc1ccc(NC(=O)N[C@H](C)c2cnn(CC)c2C)cc1.,CCOc1ccc(NC(=O)N[C@H](C)c2cnn(CC)c2C)cc1,benzene_ring
+183677,Modify the molecule C[NH2+][C@]1(C(=O)[O-])CCC[C@H](Oc2ccc(C)cc2)C1 by removing a benzene_ring.,C[NH2+][C@]1(C(=O)[O-])CCC[C@H](Oc2ccc(C)cc2)C1,benzene_ring
+196687,Remove a benzene_ring from the molecule COc1ccc([C@H](CNC(=O)c2ccc(-n3cccc3)cc2)N2CCOCC2)cc1.,COc1ccc([C@H](CNC(=O)c2ccc(-n3cccc3)cc2)N2CCOCC2)cc1,benzene_ring
+219290,Modify the molecule Cc1cccc2c(CCNC(=O)N(C)Cc3ccccc3O)c[nH]c12 by removing a benzene_ring.,Cc1cccc2c(CCNC(=O)N(C)Cc3ccccc3O)c[nH]c12,benzene_ring
+186887,Modify the molecule C[C@@H](C(=O)N1CCc2ccccc2C1)[NH+]1CCC[C@H](O)C1 by removing a amide.,C[C@@H](C(=O)N1CCc2ccccc2C1)[NH+]1CCC[C@H](O)C1,amide
+191341,Remove a amide from the molecule CCO[C@@H](C)c1noc(CN2CCN(C(=O)CC(F)(F)F)CC2)n1.,CCO[C@@H](C)c1noc(CN2CCN(C(=O)CC(F)(F)F)CC2)n1,amide
+112066,Please remove a benzene_ring from the molecule COc1cccc(C(=O)/N=C(/[N-]Cc2cccnc2)Nc2ccc(Cl)cc2C)c1.,COc1cccc(C(=O)/N=C(/[N-]Cc2cccnc2)Nc2ccc(Cl)cc2C)c1,benzene_ring
+203923,Please remove a amine from the molecule O=C(NC(=S)Nc1cccc(CO)c1)c1ccccc1[N+](=O)[O-].,O=C(NC(=S)Nc1cccc(CO)c1)c1ccccc1[N+](=O)[O-],amine
+163942,Modify the molecule O=C(c1cccc(S(=O)(=O)Oc2ccc(Cl)cc2)c1)N1CCCC1 by removing a benzene_ring.,O=C(c1cccc(S(=O)(=O)Oc2ccc(Cl)cc2)c1)N1CCCC1,benzene_ring
+38540,Please remove a benzene_ring from the molecule CCC(=O)N(C)c1ccccc1C(=O)NCC(=O)OC(C)(C)C.,CCC(=O)N(C)c1ccccc1C(=O)NCC(=O)OC(C)(C)C,benzene_ring
+217086,Please remove a benzene_ring from the molecule O=Cc1cccc(OCc2cccc3ccccc23)c1.,O=Cc1cccc(OCc2cccc3ccccc23)c1,benzene_ring
+31294,Please remove a amide from the molecule Cc1nsnc1COc1cccc(C(=O)N[C@@H]2CCS(=O)(=O)C2)c1.,Cc1nsnc1COc1cccc(C(=O)N[C@@H]2CCS(=O)(=O)C2)c1,amide
+59246,Modify the molecule CCc1onc(C)c1NC(=O)N(Cc1ccc(Cl)c(Cl)c1)C1CC1 by removing a benzene_ring.,CCc1onc(C)c1NC(=O)N(Cc1ccc(Cl)c(Cl)c1)C1CC1,benzene_ring
+17484,Remove a benzene_ring from the molecule CCN(C(=O)c1cc(C2CC2)n(C(C)(C)C)n1)c1ccc(F)c(F)c1.,CCN(C(=O)c1cc(C2CC2)n(C(C)(C)C)n1)c1ccc(F)c(F)c1,benzene_ring
+153060,Please remove a amide from the molecule C[C@@H](OC(=O)c1ccc2c(c1)CCC(=O)N2)C(=O)Nc1ccc(Cl)cn1.,C[C@@H](OC(=O)c1ccc2c(c1)CCC(=O)N2)C(=O)Nc1ccc(Cl)cn1,amide
+19390,Remove a benzene_ring from the molecule COc1c(C)cccc1C1=N/C(=C\c2ccc([N+](=O)[O-])cc2)C(=O)O1.,COc1c(C)cccc1C1=N/C(=C\c2ccc([N+](=O)[O-])cc2)C(=O)O1,benzene_ring
+237517,Remove a benzene_ring from the molecule CCN(C(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12)c1ccccc1.,CCN(C(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12)c1ccccc1,benzene_ring
+8470,Please remove a benzene_ring from the molecule C[NH+]1CCC(N(Cc2ccco2)C(=S)Nc2cc(Cl)ccc2C(F)(F)F)CC1.,C[NH+]1CCC(N(Cc2ccco2)C(=S)Nc2cc(Cl)ccc2C(F)(F)F)CC1,benzene_ring
+80717,Remove a benzene_ring from the molecule CCOc1ccc([C@H](C)[NH2+]CC(C)(C)N2CCS(=O)CC2)cc1.,CCOc1ccc([C@H](C)[NH2+]CC(C)(C)N2CCS(=O)CC2)cc1,benzene_ring
+147498,Modify the molecule COc1ccc(OC)c(CCC(=O)Nc2cccc(-c3n[nH]c(C)n3)c2)c1 by removing a benzene_ring.,COc1ccc(OC)c(CCC(=O)Nc2cccc(-c3n[nH]c(C)n3)c2)c1,benzene_ring
+99405,Remove a amide from the molecule CC(C)CC(C)(C)C(=O)NC1CCN(c2ccccc2)CC1.,CC(C)CC(C)(C)C(=O)NC1CCN(c2ccccc2)CC1,amide
+155066,Please remove a halo from the molecule O=C(COC(=O)c1ccco1)Nc1cc(S(=O)(=O)N2CCCCC2)ccc1Cl.,O=C(COC(=O)c1ccco1)Nc1cc(S(=O)(=O)N2CCCCC2)ccc1Cl,halo
+29606,Remove a benzene_ring from the molecule Nc1cccc(C(=O)/C=C/c2ccccc2)c1.,Nc1cccc(C(=O)/C=C/c2ccccc2)c1,benzene_ring
+221152,Modify the molecule C[C@@H]1C[C@@H](C)C[NH+](CCNC(=O)NCc2ccccc2F)C1 by removing a halo.,C[C@@H]1C[C@@H](C)C[NH+](CCNC(=O)NCc2ccccc2F)C1,halo
+232163,Please remove a benzene_ring from the molecule CC(=O)N1CC[C@@H](NC(=O)NCc2ccc(N3CC[NH+](CC4CC4)CC3)cc2)C1.,CC(=O)N1CC[C@@H](NC(=O)NCc2ccc(N3CC[NH+](CC4CC4)CC3)cc2)C1,benzene_ring
+220152,Please remove a amide from the molecule COC(=O)[C@H](CC(C)C)NC(=O)c1cnc2ccc(C)cn12.,COC(=O)[C@H](CC(C)C)NC(=O)c1cnc2ccc(C)cn12,amide
+235590,Modify the molecule Cc1cc(C)cc(NC(=O)c2ccc(Cl)c(N)c2)c1 by removing a amine.,Cc1cc(C)cc(NC(=O)c2ccc(Cl)c(N)c2)c1,amine
+66874,Please remove a benzene_ring from the molecule CN(C)S(=O)(=O)c1cccc(C(=O)NNC(=O)CC2CCCC2)c1.,CN(C)S(=O)(=O)c1cccc(C(=O)NNC(=O)CC2CCCC2)c1,benzene_ring
+57681,Remove a nitro from the molecule Nc1ccc(C(=O)Nc2ccccc2SC(F)F)cc1[N+](=O)[O-].,Nc1ccc(C(=O)Nc2ccccc2SC(F)F)cc1[N+](=O)[O-],nitro
+118391,Please remove a amide from the molecule CC1(C)Cc2c(sc(NC(=O)C(=O)NC[C@@H]3CCCO3)c2C(N)=O)CO1.,CC1(C)Cc2c(sc(NC(=O)C(=O)NC[C@@H]3CCCO3)c2C(N)=O)CO1,amide
+209027,Please remove a halo from the molecule O=[N+]([O-])[C@H]1C[C@@H]1/C([O-])=N/S(=O)(=O)c1ccc(Cl)s1.,O=[N+]([O-])[C@H]1C[C@@H]1/C([O-])=N/S(=O)(=O)c1ccc(Cl)s1,halo
+79306,Please remove a amine from the molecule O=S(=O)(NC[C@H](c1cccs1)S(=O)(=O)c1ccc(Cl)cc1)c1ccc(F)cc1.,O=S(=O)(NC[C@H](c1cccs1)S(=O)(=O)c1ccc(Cl)cc1)c1ccc(F)cc1,amine
+92669,Remove a benzene_ring from the molecule CCc1nnc(NC(=O)NCc2cccc(C[NH+](C)C)c2)s1.,CCc1nnc(NC(=O)NCc2cccc(C[NH+](C)C)c2)s1,benzene_ring
+148157,Remove a amide from the molecule CC[C@H](Sc1nncn1C(C)(C)C)C(=O)NCc1ccccc1.,CC[C@H](Sc1nncn1C(C)(C)C)C(=O)NCc1ccccc1,amide
+61749,Please remove a amide from the molecule Cc1nnc(S[C@H](C)C(=O)N(C)c2ccccc2)n1-c1ccccc1.,Cc1nnc(S[C@H](C)C(=O)N(C)c2ccccc2)n1-c1ccccc1,amide
+233334,Please remove a benzene_ring from the molecule O=C(NCc1nccc2ccccc12)c1c(Cl)cccc1Cl.,O=C(NCc1nccc2ccccc12)c1c(Cl)cccc1Cl,benzene_ring
+115375,Modify the molecule CCc1ccc(C2=CCN(C(=O)c3ccc(Cl)nc3)CC2)cc1 by removing a amide.,CCc1ccc(C2=CCN(C(=O)c3ccc(Cl)nc3)CC2)cc1,amide
+37078,Please remove a amide from the molecule COc1ccnc(N2CCc3c(cccc3NC(C)=O)C2)n1.,COc1ccnc(N2CCc3c(cccc3NC(C)=O)C2)n1,amide
+8175,Modify the molecule CC(=O)N1CCC([C@H]2CC=CCN(Cc3ccccc3)C2=O)CC1 by removing a benzene_ring.,CC(=O)N1CCC([C@H]2CC=CCN(Cc3ccccc3)C2=O)CC1,benzene_ring
+171564,Remove a amide from the molecule C=CCO[C@H](C)C(=O)Oc1ccc2c(c1)CCC(=O)N2.,C=CCO[C@H](C)C(=O)Oc1ccc2c(c1)CCC(=O)N2,amide
+4959,Remove a halo from the molecule C[C@H]1CC(Oc2c(F)cc(CC[NH3+])cc2F)C[C@H](C)C1.,C[C@H]1CC(Oc2c(F)cc(CC[NH3+])cc2F)C[C@H](C)C1,halo
+185293,Remove a amide from the molecule O=C(c1cnccn1)N(Cc1ccc2c(c1)OCO2)C1CCCC1.,O=C(c1cnccn1)N(Cc1ccc2c(c1)OCO2)C1CCCC1,amide
+8189,Please remove a halo from the molecule C[C@@H]1CC[C@H](NC(=O)Nc2cc(C(=O)N(C)C)ccc2F)[C@H](C)C1.,C[C@@H]1CC[C@H](NC(=O)Nc2cc(C(=O)N(C)C)ccc2F)[C@H](C)C1,halo
+111176,Please remove a amine from the molecule Cc1ccc(S(=O)(=O)Nc2ccccc2N2CCCC2)cc1[N+](=O)[O-].,Cc1ccc(S(=O)(=O)Nc2ccccc2N2CCCC2)cc1[N+](=O)[O-],amine
+163205,Remove a hydroxyl from the molecule CCOc1ccc(NC(=O)N(C)CC[C@@H](C)O)cc1OC.,CCOc1ccc(NC(=O)N(C)CC[C@@H](C)O)cc1OC,hydroxyl
+130918,Please remove a amide from the molecule O=C(Nc1cccc(C(=O)Nc2nccs2)c1)c1ccc2c(c1)C(=O)N(C[C@@H]1CCCO1)C2=O.,O=C(Nc1cccc(C(=O)Nc2nccs2)c1)c1ccc2c(c1)C(=O)N(C[C@@H]1CCCO1)C2=O,amide
+80901,Please remove a amide from the molecule COc1ccc([C@@H](OC)[C@@H](C)NC(=O)c2sc(C(C)C)nc2C)cc1.,COc1ccc([C@@H](OC)[C@@H](C)NC(=O)c2sc(C(C)C)nc2C)cc1,amide
+119108,Modify the molecule C[C@H](NC(=O)NC[C@@H](c1ccco1)[NH+](C)C)c1ccc(C(F)(F)F)cc1 by removing a halo.,C[C@H](NC(=O)NC[C@@H](c1ccco1)[NH+](C)C)c1ccc(C(F)(F)F)cc1,halo
+127321,Remove a benzene_ring from the molecule CN(C(=O)COCCOc1ccccc1)c1cccc2ncccc12.,CN(C(=O)COCCOc1ccccc1)c1cccc2ncccc12,benzene_ring
+245840,Please remove a benzene_ring from the molecule Cc1ccccc1Cc1noc(CN2CCC[C@@H](C[NH+]3CCCC[C@@H]3C)C2)n1.,Cc1ccccc1Cc1noc(CN2CCC[C@@H](C[NH+]3CCCC[C@@H]3C)C2)n1,benzene_ring
+148288,Remove a benzene_ring from the molecule COc1ccc([N+](=O)[O-])cc1S(=O)(=O)N[C@@H](c1ccccc1)c1ccco1.,COc1ccc([N+](=O)[O-])cc1S(=O)(=O)N[C@@H](c1ccccc1)c1ccco1,benzene_ring
+230991,Modify the molecule C[C@H]1CCN(C(=O)c2cc(=O)[nH]c3cc(F)ccc23)[C@@H](C)C1 by removing a amide.,C[C@H]1CCN(C(=O)c2cc(=O)[nH]c3cc(F)ccc23)[C@@H](C)C1,amide
+75352,Remove a amide from the molecule Cc1cccc(C(=O)N2CCC[C@H](Nc3ccc(F)cc3)C2)c1.,Cc1cccc(C(=O)N2CCC[C@H](Nc3ccc(F)cc3)C2)c1,amide
+50681,Please remove a amide from the molecule COc1ccc2[nH]cc(C(=O)N[C@@H](C(=O)Nc3ccc(C)cc3)c3ccccc3)c2n1.,COc1ccc2[nH]cc(C(=O)N[C@@H](C(=O)Nc3ccc(C)cc3)c3ccccc3)c2n1,amide
+205363,Please remove a benzene_ring from the molecule CN(CCO)C(=O)C[C@H]1C(=O)NCCN1Cc1ccc(F)c(F)c1.,CN(CCO)C(=O)C[C@H]1C(=O)NCCN1Cc1ccc(F)c(F)c1,benzene_ring
+175432,Modify the molecule CCCCOC(=O)c1cccc([N+](=O)[O-])c1C by removing a benzene_ring.,CCCCOC(=O)c1cccc([N+](=O)[O-])c1C,benzene_ring
+85844,Modify the molecule Cc1nc2c(cnn2C(C)C)cc1C(=O)N1CCC[C@H](c2[nH]cc[nH+]2)C1 by removing a amide.,Cc1nc2c(cnn2C(C)C)cc1C(=O)N1CCC[C@H](c2[nH]cc[nH+]2)C1,amide
+60204,Please remove a hydroxyl from the molecule Cc1cc([C@@H](C)NC(=O)CCCCO)c(C)s1.,Cc1cc([C@@H](C)NC(=O)CCCCO)c(C)s1,hydroxyl
+92585,Please remove a amide from the molecule Cc1cccc(NC(=O)Cn2ncccc2=O)c1.,Cc1cccc(NC(=O)Cn2ncccc2=O)c1,amide
+213680,Please remove a benzene_ring from the molecule Cn1cc(COC(=O)/C=C/c2ccccc2OC(F)(F)F)cn1.,Cn1cc(COC(=O)/C=C/c2ccccc2OC(F)(F)F)cn1,benzene_ring
+136356,Remove a amide from the molecule Cc1ccc(CCCC(=O)NCc2nc(-c3ccncc3)no2)s1.,Cc1ccc(CCCC(=O)NCc2nc(-c3ccncc3)no2)s1,amide
+109610,Please remove a hydroxyl from the molecule O=C(NC[C@@H]1CC[C@H](C(=O)[O-])O1)c1ccc(CO)cc1.,O=C(NC[C@@H]1CC[C@H](C(=O)[O-])O1)c1ccc(CO)cc1,hydroxyl
+217490,Modify the molecule CC(=O)Oc1cccc(/C=C(\C#N)C(=O)Nc2ccc(Cl)cc2[N+](=O)[O-])c1 by removing a nitro.,CC(=O)Oc1cccc(/C=C(\C#N)C(=O)Nc2ccc(Cl)cc2[N+](=O)[O-])c1,nitro
+229756,Remove a benzene_ring from the molecule O=NNc1nc2ccccc2n1Cc1ccccc1.,O=NNc1nc2ccccc2n1Cc1ccccc1,benzene_ring
+237014,Remove a amide from the molecule Cc1n[nH]c(-c2ccc(NC(=O)CCC(C)C)cc2)n1.,Cc1n[nH]c(-c2ccc(NC(=O)CCC(C)C)cc2)n1,amide
+99567,Please remove a nitro from the molecule CNc1ncnc(NC[C@H]2CCCO2)c1[N+](=O)[O-].,CNc1ncnc(NC[C@H]2CCCO2)c1[N+](=O)[O-],nitro
+215495,Remove a amide from the molecule CCCCn1nc(C(=O)N2CCC(C(=O)c3ccc4c(c3)OCCO4)CC2)c2ccccc2c1=O.,CCCCn1nc(C(=O)N2CCC(C(=O)c3ccc4c(c3)OCCO4)CC2)c2ccccc2c1=O,amide
+103396,Modify the molecule O=[N+]([O-])c1ccc(-c2nc(=S)c3c(n2-c2ccccc2)CCCC3)cc1 by removing a nitro.,O=[N+]([O-])c1ccc(-c2nc(=S)c3c(n2-c2ccccc2)CCCC3)cc1,nitro
+209214,Please remove a benzene_ring from the molecule Cc1ccc(-c2nc(C[NH2+]C3CCN(c4cccc(C)[nH+]4)CC3)co2)cc1.,Cc1ccc(-c2nc(C[NH2+]C3CCN(c4cccc(C)[nH+]4)CC3)co2)cc1,benzene_ring
+189757,Please remove a halo from the molecule COc1ccc([C@@H]2CN(C(=O)c3cccc(Cl)c3)C[C@H]2C(=O)NCCC(C)C)cc1.,COc1ccc([C@@H]2CN(C(=O)c3cccc(Cl)c3)C[C@H]2C(=O)NCCC(C)C)cc1,halo
+151632,Please remove a halo from the molecule O=C(Cc1ccncc1)N1CCC[C@H](c2cccc(Cc3ccccc3F)n2)C1.,O=C(Cc1ccncc1)N1CCC[C@H](c2cccc(Cc3ccccc3F)n2)C1,halo
+63729,Remove a benzene_ring from the molecule COc1ccc(/C=C2\Oc3c(CN4CCOCC4)c(O)cc(C)c3C2=O)c(OC)c1.,COc1ccc(/C=C2\Oc3c(CN4CCOCC4)c(O)cc(C)c3C2=O)c(OC)c1,benzene_ring
+131873,Remove a hydroxyl from the molecule CCOCCSc1nc([O-])c2cnn(CCO)c2n1.,CCOCCSc1nc([O-])c2cnn(CCO)c2n1,hydroxyl
+149290,Please remove a amide from the molecule O=C(N/N=C/c1ccccc1F)c1cncc(Br)c1.,O=C(N/N=C/c1ccccc1F)c1cncc(Br)c1,amide
+77383,Remove a hydroxyl from the molecule COc1ccc2c(c1)c(C(=O)N/N=C/c1ccc(O)c(O)c1)c(C)n2C.,COc1ccc2c(c1)c(C(=O)N/N=C/c1ccc(O)c(O)c1)c(C)n2C,hydroxyl
+131395,Please remove a benzene_ring from the molecule COc1cc(/C=N/NC(=O)c2cc(Cl)ccc2O)ccc1OCC(=O)[O-].,COc1cc(/C=N/NC(=O)c2cc(Cl)ccc2O)ccc1OCC(=O)[O-],benzene_ring
+96641,Please remove a amide from the molecule C[C@](O)(CNC(=O)c1n[nH]c2ccccc12)c1ccsc1.,C[C@](O)(CNC(=O)c1n[nH]c2ccccc12)c1ccsc1,amide
+201743,Please remove a amide from the molecule COCC(=O)N[C@H](C)c1nc2ccccc2[nH]1.,COCC(=O)N[C@H](C)c1nc2ccccc2[nH]1,amide
+39688,Please remove a benzene_ring from the molecule CCCNC(=O)[C@@H](C)S(=O)(=O)Cc1cc(-c2ccccc2)on1.,CCCNC(=O)[C@@H](C)S(=O)(=O)Cc1cc(-c2ccccc2)on1,benzene_ring
+217104,Please remove a amide from the molecule CC(=O)c1cc2c(cc1NC(=O)CCC(C)C)OCO2.,CC(=O)c1cc2c(cc1NC(=O)CCC(C)C)OCO2,amide
+138476,Remove a benzene_ring from the molecule N#C[C@@H](c1ccccc1)[C@@H]1CCCN1c1ccc([N+](=O)[O-])cc1.,N#C[C@@H](c1ccccc1)[C@@H]1CCCN1c1ccc([N+](=O)[O-])cc1,benzene_ring
+53134,Please remove a benzene_ring from the molecule COCCn1ccc2ccc(NC(=O)[C@H](C)c3ccc(OC)cc3)cc21.,COCCn1ccc2ccc(NC(=O)[C@H](C)c3ccc(OC)cc3)cc21,benzene_ring