PERF: Severe performance hit on DataFrame.sum with multi index and 'skipna=False'
`Series.sum(..., skipna=False)` and `DataFrame.sum(..., skipna=False)` are *very* slow on a `MultiIndex`, 
if compared to the same method called with `(..., skipna=True)`

---

- [x] I have checked that this issue has not already been reported.

- [x] I have confirmed this bug exists on the latest version of pandas.

- [ ] (optional) I have confirmed this bug exists on the master branch of pandas.

---

#### Code Sample, a copy-pastable example

```python
import pandas as pd
import numpy as np

dims = (1000, 100, 10)

# make random data
rg = np.random.default_rng(0)
x = rg.random(dims)

# construct dataframe with multindex
idx = pd.MultiIndex.from_product(map(range, dims), names=["i0", "i1", "i2"])
df = pd.Series(data=x.ravel(), index=idx, name="x")

# comupute sum over "i2" level in pandas
s1 = df.sum(level=["i0", "i1"], skipna=False)
s2 = df.sum(level=["i0", "i1"], skipna=True)

# compute sum over "axis=2" in numpy
s_ref = x.sum(axis=2)

# check results
s_ref_norm = np.linalg.norm(s_ref)
for s in (s1, s2):
    print(np.linalg.norm(s.to_numpy().reshape(s_ref.shape) - s_ref) / s_ref_norm)
```

#### Problem description

The computation of `s1 = df.sum(level=["i0", "i1"], skipna=False)` takes forever in the sample above:

```python
In [2]: %timeit df.sum(level=["i0", "i1"], skipna=False)
8.44 s ± 47.8 ms per loop (mean ± std. dev. of 7 runs, 1 loop each)

In [3]: %timeit df.sum(level=["i0", "i1"], skipna=True)
52.1 ms ± 266 µs per loop (mean ± std. dev. of 7 runs, 10 loops each)

In [4]: %timeit x.sum(axis=2)
1.09 ms ± 13.5 µs per loop (mean ± std. dev. of 7 runs, 1000 loops each)
```
Here we see a severe performance hit (8.61 s vs 0.05 s) for the very same `DataFrame.sum` if `skipna=False`.
Maybe this is related to #16788 and #37622

The performance of `df.sum(level=["i0", "i1"], skipna=True)` with respect to baseline numpy is not great, but I think this is not an issue here.

Results are correct, fortunately. Curiously the slow result (`skipna=False`) is identical with the reference numpy sum, while the faster result (`skipna=True`) is within ±2 ULP, but of course this is not a concern.

Almost the same results hold if we use a `DataFrame` instead of a `Series`

#### Output of ``pd.show_versions()``

<details>

INSTALLED VERSIONS
------------------
commit           : 67a3d4241ab84419856b84fc3ebc9abcbe66c6b3
python           : 3.8.2.final.0
python-bits      : 64
OS               : Darwin
OS-release       : 19.6.0
Version          : Darwin Kernel Version 19.6.0: Thu Oct 29 22:56:45 PDT 2020; root:xnu-6153.141.2.2~1/RELEASE_X86_64
machine          : x86_64
processor        : i386
byteorder        : little
LC_ALL           : None
LANG             : None
LOCALE           : None.UTF-8

pandas           : 1.1.4
numpy            : 1.19.4
pytz             : 2020.1
dateutil         : 2.8.1
pip              : 20.2.4
setuptools       : 49.6.0
Cython           : None
pytest           : 6.0.1
hypothesis       : None
sphinx           : None
blosc            : None
feather          : None
xlsxwriter       : None
lxml.etree       : None
html5lib         : 1.0.1
pymysql          : None
psycopg2         : None
jinja2           : 2.11.2
IPython          : 7.17.0
pandas_datareader: None
bs4              : None
bottleneck       : 1.3.2
fsspec           : 0.8.0
fastparquet      : None
gcsfs            : None
matplotlib       : 3.3.2
numexpr          : 2.7.1
odfpy            : None
openpyxl         : 3.0.3
pandas_gbq       : None
pyarrow          : 1.0.1
pytables         : None
pyxlsb           : None
s3fs             : 0.5.0
scipy            : 1.5.3
sqlalchemy       : None
tables           : 3.6.1
tabulate         : 0.8.7
xarray           : 0.16.0
xlrd             : 1.2.0
xlwt             : None
numba            : 0.51.1
</details>
