the effect of midazolam lasts between one and six hours.
how long does the effect of midazolam last?
between one and six hours
midazolam, marketed under the trade name versed, among others, is a medication used for anesthesia, procedural sedation, trouble sleeping, and severe agitation. it works by inducing sleepiness, decreasing anxiety, and causing a loss of ability to create new memories. it is also useful for the treatment of seizures. midazolam can be given by mouth, intravenously, or injection into a muscle, by spraying into the nose, or through the cheek. when given intravenously, it typically begins working within five minutes; when injected into a muscle, it can take fifteen minutes to begin working. effects last for between one and six hours.
midazolam
midazolam is a short-acting benzodiazepine in adults with an elimination half-life of 1.5–2.5 hours. in the elderly, as well as young children and adolescents, the elimination half-life is longer. midazolam is metabolised into an active metabolite alpha1-hydroxymidazolam. age-related deficits, renal and liver status affect the pharmacokinetic factors of midazolam as well as its active metabolite. however, the active metabolite of midazolam is minor and contributes to only 10 percent of biological activity of midazolam. midazolam is poorly absorbed orally, with only 50 percent of the drug reaching the bloodstream. midazolam is metabolised by cytochrome p450 (cyp) enzymes and by glucuronide conjugation. the therapeutic as well as adverse effects of midazolam are due to its effects on the gaba receptors; midazolam does not activate gaba receptors directly but, as with other benzodiazepines, it enhances the effect of the neurotransmitter gaba on the gaba receptors (↑ frequency of cl channel opening) resulting in neural inhibition. almost all of the properties can be explained by the actions of benzodiazepines on gaba receptors. this results in the following pharmacological properties being produced: sedation, induction of sleep, reduction in anxiety, anterograde amnesia, muscle relaxation and anticonvulsant effects.
midazolam