epidermal dendritic (langerhans) cells function as part of the adaptive immune response.
epidermal dendritic (langerhans) cells function as part of the?
adaptive immune response
langerhans cells are a natural agent of antigen release. they are the precursors of dendritic cells in the skin and mucosa. lisziewicz and her team developed synthetic nanoparticles that act like pathogens and specially target langerhans cells in epidermal cell cultures. when these nanoparticles are applied topically to human subjects, a strong immune response was observed. this vaccine has been clinically proven, and it opens the door for more new dendritic cell-targeting vaccines to be created for the treatment of cancers.
julianna lisziewicz
they should not be confused with langerhans cells, which are mononuclear epidermal dendritic cells derived (like langhans cells) from monocytes and named after paul langerhans. (the islets of langerhans are also named after paul langerhans.)





















































section::::causes.





















































in 2012, a research paper showed that when activated cd4+ t cells and monocytes are in close contact, interaction of cd40-cd40l between these two cells and subsequent ifnγ secretion by the t cells causes upregulation and secretion of fusion-related molecule dc-stamp (dendritic cell-specific transmembrane protein) by the monocytes, which results in lgc formation.





















































section::::clinical significance.
langhans giant cell