blood factor xiiia is the protein that is responsible for the breakdown of a fibrin clot.
which protein is responsible for the breakdown of a fibrin clot?
blood factor xiiia
under homeostatic conditions, the body is maintained in a finely tuned balance of coagulation and fibrinolysis. the activation of the coagulation cascade yields thrombin that converts fibrinogen to fibrin; the stable fibrin clot being the final product of hemostasis. the fibrinolytic system then functions to break down fibrinogen and fibrin. activation of the fibrinolytic system generates plasmin (in the presence of thrombin), which is responsible for the lysis of fibrin clots. the breakdown of fibrinogen and fibrin results in polypeptides called fibrin degradation products (fdps) or fibrin split products (fsps). in a state of homeostasis, the presence of plasmin is critical, as it is the central proteolytic enzyme of coagulation and is also necessary for the breakdown of clots, or fibrinolysis.
disseminated intravascular coagulation
platelet-rich fibrin (prf) or leucocyte- and platelet-rich fibrin (l-prf) is a second-generation prp where autologous platelets and leucocytes are present in a complex fibrin matrix to accelerate the healing of soft and hard tissue and is used as a tissue-engineering scaffold for endodontics. to obtain prf, required quantity of blood is drawn quickly into test tubes without an anticoagulant and centrifuged immediately. blood can be centrifuged using a tabletop centrifuge for at least 10 min at 3000 revolution per minute. the resultant product consists of the following three layers; topmost layer consisting of platelet poor plasma, prf clot in the middle, and red blood cells at the bottom. prf is available as a fibrin clot. prf clot can be removed from the test tube using a sterile tweezer-like instrument. after lifting, the rbc layer attached to the prf clot can be carefully removed using a sterilized scissor. platelet activation in response to tissue damage occurs during the process of making prf release several biologically active proteins including; platelet alpha granules, platelet‑derived growth factor (pgdf), transforming growth factors‑β (tgf‑β), vascular endothelial growth factor (vegf), and epidermal growth factor. actually the platelets and leukocyte cytokines are important part in role play of this biomaterial, but the fibrin matrix supporting them is very helpful in constituting the determining elements responsible for real therapeutic potential of prf. cytokines are immediately used and destroyed in a healing wound. the harmony between cytokines and their supporting fibrin matrix has much more unique importance than any other platelet derivatives.
platelet-rich fibrin