the wreck of the titanic was found in 1985.
when was the wreck of the titanic found?
1985
objects from "titanic" have been exhibited for many years, though only a few were retrieved before the discovery of the wreck in 1985. the maritime museum of the atlantic in halifax, nova scotia has a collection of wooden fragments and an intact deckchair plucked from the sea by the canadian search vessels that recovered the victims' bodies. various other museums, including the national maritime museum in greenwich and the seacity museum in southampton, have objects donated by survivors and relatives of victims, including some items that were retrieved from the bodies of victims. more donated "titanic" artefacts are to be found in the merseyside maritime museum in liverpool and the titanic historical society's museum in indian orchard, springfield, massachusetts. the latter's collection includes items such as the life jacket of madeleine astor, the wife of millionaire "titanic" victim john jacob astor iv, a rivet which was removed from the hull before "titanic" went to sea, an ice warning which never reached the bridge, a restaurant menu and a sample square of carpet from a first class stateroom.
wreck of the rms titanic
"b. ovatus" has been used in animal studies as a mode of microbial drug delivery due to its xylanase operon. operons exist in bacteria to control gene expression and are composed of a dna sequence containing an operator followed by the genes of interest. the operator in the xylanase operon prevents transcription of genes when bound to a repressor protein. the "b. ovatus" xylanase operon only functions in the presence of the starch, xylan, which removes the repressor and enables production of whichever proteins correlate with the genes located after the operator. for microbial drug delivery, the genes after the operator include those inserted as part of the genetic modification. xylan is non-digestible to human gastric acid or digestive enzymes, so a predictable quantity of dietary xylan will reach the recombinant "b. ovatus" in the gut, hypothetically allowing for a precise quantity of drug to be produced by the recombinant "b. ovatus". in mice, recombinant "b. ovatus" strains containing genes for growth factors tgf-β and kgf-2 within the xylanase operon have successfully treated ulcerative colitis (uc). the secreted drugs from "b. ovatus" are applied topically to the epithelial lining, affecting local tissues rather than acting systemically. systemic administration of these growth factors could otherwise cause tumors and increased vascularization of tissues. when administered microbially, tgf-β and kgf-2 facilitate tissue repair only in the colon where they are released.
microbial drug delivery