a substance that causes an allergic reaction triggers the release of a class of substances known as histamine.
a substance that causes an allergic reaction triggers the release of a class of substances known as?
histamine
clinical trials and post-market safety data indicate that the most common adverse side effect of aldurazyme is allergic reaction. in order to prevent allergic reaction and respiratory distress, the packet insert of aldurazyme suggests that patients be administered antihistamines before infusion. allergic reaction occurs in approximately 1% of patients. it is recommended that patients who are high-risk for respiratory distress be given their infusion in a facility equipped to deal with an anaphylactic response. (high-risk factors include sleep apnea, respiratory impairment, respiratory illness, or previous experience with allergic reaction to aldurazyme. it is noted that risk-benefit must be weighed for patients with history of severe allergic response as to whether the drug should be administered again.) in a 2002 memorandum, melanie hartsough, ph.d., dtp of the fda's department of health and human services stated, "aggregation of product could enhance immune responses, specifically neutralizing antibody, which may limit the response to therapy, whereas highly deaggregated product may induce immune tolerance." it appears that she then went on to ask for further justification of some relevant aspect of the production process, though the majority of this particular memorandum has not been publicly released and it is unclear as to whether this concern is relevant to the high rate of allergic response to this drug.
iduronidase
an allergic reaction will not occur on the first exposure to a substance. the first exposure allows the body to create antibodies and memory lymphocyte cells for the antigen. however, drugs often contain many different substances, including dyes, which could cause allergic reactions. this can cause an allergic reaction on the first administration of a drug. for example, a person who developed an allergy to a red dye will be allergic to any new drug which contains that red dye.
drug allergy