cardiac cells have the ability to generate an electrical impulse which is called contraction.
cardiac cells have the ability to generate an electrical impulse which is called?
contraction
section::::mechanism.





























hypoxia provokes potassium efflux from cardiac muscles cells via the activation of atp-sensitive potassium channels (katp). potassium efflux from cardiac cells decreases action potential duration and results in non-uniform repolarization of the cardiac cells. the heterogeneous repolarization of the cardiac tissue permits reentry of action potentials into conducting pathways, which manifests as malignant arrhythmias in the heart. hmr 1883 is a cardioselective atp-sensitive potassium channel antagonist that prevents the potassium efflux, hence corrects the non-uniform refractory period in the ischemic tissue. a uniform refractory period corrects the conductance problems in the heart and prevents the re-entry arrhythmias.





























section::::side effects.
hmr 1883
if embryonic heart cells are separated into a petri dish and kept alive, each is capable of generating its own electrical impulse followed by contraction. when two independently beating embryonic cardiac muscle cells are placed together, the cell with the higher inherent rate sets the pace, and the impulse spreads from the faster to the slower cell to trigger a contraction. as more cells are joined together, the fastest cell continues to assume control of the rate. a fully developed adult heart maintains the capability of generating its own electrical impulse, triggered by the fastest cells, as part of the cardiac conduction system. the components of the cardiac conduction system include the atrial and ventricular syncytium, the sinoatrial node, the atrioventricular node, the bundle of his (atrioventricular bundle), the bundle branches, and the purkinje cells.
cardiac physiology