endothelial cells contribute to the blood-brain barrier in the central nervous system by restricting passage of substances.
what type of cell contributes to the blood-brain barrier in the central nervous system by restricting passage of substances?
endothelial cells
meningitis inflames and breaks down any protective membrane and cells surrounding the brain, spinal cord, and other parts of the nervous system. bacterial meningitis is normally caused by a bacterial infection that enters the bloodstream and enters the blood-brain barrier. the blood-brain barrier consists of tight junctions. these tight junctions help to enclose endothelial cells that line the brain capillaries. only certain water-soluble substances can move across the blood-brain barrier, while lipid-soluble substances can easily move across the blood-brain barrier. however, when any form of bacteria gets through to the blood-brain barrier, a bacterial infection can result in the cerebrospinal fluid.
meningeal syphilis
the blood–brain barrier refers to a diffusion barrier formed by the endothelial walls of the blood vessels and capillaries in the brain. this barrier prevents most substances in the blood from entering the brain while allowing small molecules like oxygen and carbon dioxide to diffuse freely. while working at the university of geneva, stern published a series of studies demonstrating the existence of the blood-brain barrier with colleague raymond gautier. beginning in 1918, the two performed systematic experiments on the movement of various substances from the blood into the nervous system and estimated the extent to which these substances were able to permeate the brain. from these studies they were able to conclude that there exists a barrier between the blood and brain, which they termed in french "barrière hématoencéphalique". in a 1934 paper, stern also independently introduced the notions of barrier selectivity and barrier resistance, realizing that the blood–brain barrier both selectively allows certain substances to enter the brain and protects the internal milieu of the brain from that of the blood. today these are acknowledged as two of the main functions of the blood–brain barrier.
lina stern