the stimulus for the formation of a platelet plug or a blood clot is endothelial injury.
the stimulus for the formation of a platelet plug or a blood clot is?
endothelial injury
hemostasis or haemostasis is a process to prevent and stop bleeding, meaning to keep blood within a damaged blood vessel (the opposite of hemostasis is hemorrhage). it is the first stage of wound healing. this involves coagulation, blood changing from a liquid to a gel. intact blood vessels are central to moderating blood's tendency to form clots. the endothelial cells of intact vessels prevent blood clotting with a heparin-like molecule and thrombomodulin and prevent platelet aggregation with nitric oxide and prostacyclin. when endothelial injury occurs, the endothelial cells stop secretion of coagulation and aggregation inhibitors and instead secrete von willebrand factor which initiate the maintenance of hemostasis after injury. hemostasis has three major steps: 1) vasoconstriction, 2) temporary blockage of a break by a platelet plug, and 3) blood coagulation, or formation of a fibrin clot. these processes seal the hole until tissues are repaired.
hemostasis
the platelet plug, also known as the hemostatic plug or platelet thrombus, is an aggregation of platelets formed during the earlier stage of hemostasis in response to blood vessel wall injury. after platelets are recruited and begin to accumulate around the breakage, their “sticky” nature allows them to adhere to each other. this forms a platelet plug, which prevents more blood from leaving the body as well as any outside contaminants from getting in. the plug provides a temporary blockage of the break in the vasculature. as such, platelet plug formation occurs after vasoconstriction of the blood vessels but before the creation of the fibrin mesh clot, which is the more permanent solution to the injury. the result of the platelet plug formation is the coagulation of blood. it can also be referred to as primary hemostasis.
platelet plug