paracetamol poisoning is the most serious toxic effect of acute acetaminophen overdose.
most serious toxic effect of acute acetaminophen overdose?
paracetamol poisoning
paracetamol poisoning, also known as acetaminophen poisoning, is caused by excessive use of the medication paracetamol (acetaminophen). most people have few or non-specific symptoms in the first 24 hours following overdose. this may include feeling tired, abdominal pain, or nausea. this is typically followed by a couple of days without any symptoms after which yellowish skin, blood clotting problems, and confusion occurs as a result of liver failure. additional complications may include kidney failure, pancreatitis, low blood sugar, and lactic acidosis. if death does not occur, people tend to recover fully over a couple of weeks. without treatment some cases will resolve while others will result in death.
paracetamol poisoning
zone 3 (centrilobular) occurs with ischemic injury, toxic effects, carbon tetrachloride exposure, or chloroform ingestion. in acute acetaminophen overdose, toxification occurs, mostly in zone iii which has the highest level of p450 micro-enzymes. that fact along with zone iii's decreased oxygen level helps to explain why it is preferentially one of the initial sites of damage.





























section::::diagnosis.





























all patients with clinical or laboratory evidence of moderate to severe acute hepatitis should have an immediate measurement of prothrombin time and careful evaluation of mental status. if the prothrombin time is prolonged by ≈ 4–6 seconds or more (inr ≥ 1.5),
acute liver failure