four different types of cancer are there.
how many different type of cancer are there?
four
Na
Na
given the ability of p130cas/bcar1 scaffold protein to convey and integrate different type of signals and subsequently to regulate key cellular functions such as adhesion, migration, invasion, proliferation and survival, the existence of a strong correlation between deregulated p130cas/bcar1 expression and cancer was inferred. deregulated expression of p130cas/bcar1 has been identified in several cancer types. altered levels of p130cas/bcar1 expression in cancers can result from gene amplification, transcription upregulation or changes in protein stability. overexpression of p130cas/bcar1 has been detected in human breast cancer, prostate cancer, ovarian cancer, lung cancer, colorectal cancer, hepatocellular carcinoma, glioma, melanoma, anaplastic large cell lymphoma and chronic myelogenous leukaemia. the presence of aberrant levels of hyperphosphorylated p130cas/bcar1 strongly promotes cell proliferation, migration, invasion, survival, angiogenesis and drug resistance. it has been demonstrated that high levels of p130cas/bcar1 expression in breast cancer correlate with worse prognosis, increased probability to develop metastasis and resistance to therapy. conversely, lowering the amount of p130cas/bcar1 expression in ovarian, breast and prostate cancer is sufficient to block tumor growth and progression of cancer cells.
bcar1