claim: sterilizing immunity against sars-cov-2 infection in rats by a single-shot and modified imidazoquinoline tlr7/8 agonist-adjuvanted recombinant spike protein vaccine
evidence_1: to correlate vaccine responses with control of virus replication in vivo , vaccinated mice were challenged with sars-cov-2 virus after being sensitized by intranasal adenovirus-mediated expression of the human angiotensin converting enzyme 2 (ace2) gene.", "imdq-peg-chol is used to induce a protective immune response against sars-cov-2 after single vaccination with trimeric recombinant sars-cov-2 spike protein in the balb/c mouse model.")