claim: widely available lysosome targeting agents should be considered as a potential biomarker for covid-19
evidence_1: as some of these drugs, mostly antibiotics, were already empirically used in the treatment of covid-19, we encourage our colleagues all over the world to publish patient data so potential efficacy of these agents can be evaluated in the clinical context and rapidly implemented in the therapeutic protocols if the beneficial effect on clinical outcome is observed.", "the main mechanism of action responsible for the favourable outcome of covid-19 patients treated with cq seems to be related to ph modulation- mediated effect on the endolysosomal trafficking, a characteristic of chemical compounds often called lysosomotropic agents because of the physico-chemical properties that enable them to passively diffuse through the endosomal membrane and undergo protonation-based trapping in the lumen of the acidic vesicles."
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  )