claim: intradermal-delivered dna vaccine provides anamnestic protection in a rhesus macaque sars-cov-2 challenge model
evidence_1: several months after vaccination, animals were challenged with sars-cov-2 resulting in rapid recall of anti-sars-cov-2 spike protein t and b cell responses.", "vaccination with ino-4800 induced t cell responses and neutralizing antibody responses against both the d614 and g614 sars-cov-2 spike proteins.", "here, we assess immunogenicity and anamnestic protective efficacy in rhesus macaques of the intradermal (id)-delivered sars-cov-2 spike dna vaccine, ino-4800.", "these studies support the immune impact of ino-4800 for inducing both humoral and cellular arms of the adaptive immune system which are likely important for providing durable protection against covid-19 disease."
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  )