claim: sars-cov-2 orf3b is a potent interferon antagonist whose activity is further blocked by a naturally occurring elongation variant
evidence_1: interestingly, extension of sars-cov2 orf3b by removal of a premature stop codon enhances its ability to antagonise ifn-β induction.", "finally, sars-cov2 isolates from two severe covid-19 cases were shown to express the extended orf3b which shows increased ifn-β antagonism.", "a natural elongation variant of sars-cov-2 orf3b isolated from two patients showed a stronger suppression of interferon induction than wildtype sars-cov-2 orf3b.", "they find the truncated orf3b encoded by sars-cov-2 (22 aa) suppresses ifn-β induction more efficiently than the full-length sars-cov ortholog (~153 aa)."
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  )