claim: the sars-cov-2 cytopathic effect is induced with autophagy modulators
evidence_1: one sentence summary blocking sars-cov-2 cytopathic effects with selective autophagy inhibitors underlying the clinical benefits of chloroquine and hydroxychloroquine.", "while it is known that chloroquine and hydroxychloroquine, extensively explored as clinical agents for covid-19, have multiple cellular effects including inhibiting autophagy, there are also dose- limiting toxicities in patients that make clearly establishing their potential mechanisms-of-action problematic.", "immunofluorescence staining for lc3b and lysotracker dye staining assays in several cell lines indicated their potency and efficacy for inhibiting autophagy correlated with the measurements in the sars-cov-2 cytopathic effect assay."
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
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