claim: a functional genomics approach to understand molecular genetic regulation of covid-19 severity
evidence_1: a functional genomics investigation based on functional characterization of individuals with high genetic risk for severe covid-19 susceptibility identified several major patterns: i. a large impact of genetically determined innate immune responses in covid-19, with increased susceptibility for severe disease in individuals with defective monocyte-derived cytokine production; ii.", "here, we employed the detailed clinical, immunological and multi-omics data of the human functional genomics projects (hfgp) to explore the physiological significance of the host genetic variants that influence susceptibility to severe covid-19.", 
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  "our findings allow a physiological understanding of genetic susceptibility to severe covid-19, and indicate pathways that could be targeted for prevention and therapy.")