claim: gns561 exhibits potent in vitro antiviral activity against sars-cov-2 through autophagy inhibition
evidence_1: overall, our study highlights gns561 as a powerful drug in sars- cov-2 infection and supports that the hypothesis that autophagy inhibitors could be an alternative strategy for sars-cov-2 infection.", "our data indicated that gns561 showed the highest antiviral effect for two sars-cov-2 strains compared to cq and remdesivir.", "finally, our study revealed that the combination of gns561 and remdesivir was associated with a strong synergistic antiviral effect against sars-cov-2.", "here, we investigated the antiviral activity and associated mechanism of gns561, a small basic lipophilic molecule inhibitor of late-stage autophagy, against sars-cov-2."
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
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