claim: ivermectin exposure leads to up-regulation of detoxification genes in vitro and in vivo in mice
evidence_1: gene expression of abc transporters and cytochromes was evaluated by rt-qpcr in murine hepatic and intestinal cell lines exposed to increasing ivermectin doses, and in liver and intestine of mice orally administered with single or repeated therapeutic doses of ivermectin (0.2 mg/kg).