claim: mast cells activated by sars-cov-2 release histamine which increases il-1 levels causing cytokine storm and inflammatory reaction in covid-19
evidence_1: in this pathologic environment, the activation of mast cells (mcs) causes the release of histamine, proteases, cytokines, chemokines and arachidonic acid compounds, such as prostaglandin d2 and leukotrienes, all of which are involved in the inflammatory network.", "il-1 induces throboxane-a2 (txa2) in covid-19 causing inflammation and micro-thrombi: inhibitory effect of the il-1 receptor antagonist (il-1ra).")