claim: sars-cov-2 orf6 hijacks nup98 to promote stat nuclear import and antagonize interferon signaling
evidence_1: the orf6-nup98 interaction is critical to block stat nuclear translocation and ifn signaling.", "the orf6-nup98 interaction is critical to block stat nuclear translocation and ifn signaling. fig.", "in this study, we show that sars-cov-2 is able to efficiently block stat1 and stat2 nuclear translocation in order to impair transcriptional induction of ifn-stimulated genes (isgs).", "we found that sars-cov-2 orf6 localizes at the nuclear pore complex (npc) and directly interacts with nup98-rae1 via its c-terminal domain to impair docking of cargo-receptor (karyopherin/importin) complex and disrupt nuclear import."
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  )