claim: a single immunization with spike-functionalized ferritin vaccines elicits neutralizing antibody responses against sars-cov-2 in humans.
evidence_1: analysis of antisera from immunized mice revealed that the only groups with notable neutralizing activity after a single dose of antigen were those immunized with s-fer or sδc-fer (figure 4c), underscoring that multivalent presentation greatly enhances the neutralizing antibody response in a single- dose regimen of an adjuvanted sars-cov-2 subunit vaccine.", "after a single dose, mice immunized with sδc-fer exhibited a significantly higher neutralizing antibody response than all nonferritin groups as determined using a spike-pseudotyped lentiviral assay.", 
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  "taken together, these results provide insights into development of sars-cov-2 subunit vaccines and demonstrate that spike- functionalized ferritin nanoparticles elicit an enhanced antibody response compared to the spike trimers or rbd alone.")