claim: chloroquine inhibits hmgb1 inflammatory signaling and protects mice from lethal sepsis
evidence_1: chloroquine protects mice against lethal sepsis and inhibits hmgb1 release (a) the cecal figure 3.", "here, we show that chloroquine, an anti-malarial drug, prevents lethality in mice with established endotoxemia or sepsis.", "the protective effects of chloroquine were mediated through inhibition of hmgb1 release in macrophages, monocytes, and endothelial cells, thereby preventing its cytokine-like activities.", "chloroquine protects mice against lethal sepsis and inhibits hmgb1 release (a) the cecal ligation and puncture technique was used to induce intraabdominal sepsis in mice (n = 20 per group)."
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  )