claim: fatal neuroinvasion of sars-cov-2 in k18-hace2 rats is partially dependent on hace2 expression.
evidence_1: transgenic mice expressing human angiotensin-converting enzyme 2 (hace2) under the cytokeratin 18 promoter (k18-hace2) represent a lethal model of sars-cov-2 infection.", "treatment with an anti-sars-cov neutralizing antibody protects k18- hace2 mice against clinical disease.", "sars-cov-2 caused lethal disease in k18-hace2 mice (n=33) inoculated intranasally with 1 x 106 plaque forming units (pfu).")