claim: rapid endothelialitis and vascular inflammation characterise sars-cov-2 infection in a rat lung-on-chip model
evidence_1: methods we establish a vascularised lung-on-chip infection model consisting of a co-culture of primary human alveolar epithelial cells (epithelial) and human lung microvascular endothelial cells (endothelial), with the optional addition of cd14+ macrophages to the epithelial side.", "a combination of qrt-pcr, rnascope, immunofluorescence, and elisa measurements are used to study the dynamics of viral replication and host responses to a low dose infection of sars-cov-2 delivered to the apical surface of the epithelial face maintained at an air-liquid interface."
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  )