claim: inhibition of papain-like protease plpro blocks sars- cov-2 spread and promotes anti-viral immunity
evidence_1: we propose that therapeutic targeting of plprocov2 can suppress sars-cov-2 infection and promote anti-viral immunity.", "pharmacological inhibition of plprocov2 blocks the virus-induced cytopathogenic effect upon infection with sars-cov-2, fosters the anti- viral interferon pathway and reduces viral release from infected cells.", "in human cells, plprocov2 cleaves isg15 from interferon responsive factor 3 (irf3), blocks its nuclear translocation, and reduces type i interferon responses, whereas plprosars preferentially mediates deubiquitination of critical components of the nf-kb pathway."
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
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