claim: sars-cov-2 d614g variant exhibits efficient replication ex vivo and transmission in vivo
evidence_1: using authentic sars-cov-2 isogenic variants, we show the role of the d614g substitution in enhancing viral infectivity in immortalized cell lines, growth, and fitness in primary human airway epithelial cells and hamsters, yet it marginally alters viral pathogenesis in hamster and hace2 mouse models.", "1 sars-cov-2 d614g variant shows enhanced infectivity in immortalized cell lines and replication fitness in upper human respiratory epithelia compared with the ancestral wt virus.", "sars-cov-2 s pseudotyped viruses encoding the d614g substitution were reported to exhibit increased infectivity in continuous cell lines and increased sensitivity to neutralization ( 4, 5)."
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  )