claim: il-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine development syndrome
evidence_1: our in vitro data indicate that endothelial il-6 trans- signaling formed an inflammation circuit for robust il-6, il-8, and mcp-1 production and promoted pai-1 production; additionally, an il-6 signaling blockade by the human monoclonal antibody tocilizumab blunted endothelial cell activation.