claim: synergism of tnf-α and ifn-γ reduces inflammatory cell death, tissue damage, and mortality in sars-cov-2 infection and cytokine shock syndromes
evidence_1: in vivo neutralization of both tnf-α and ifn-γ in multiple disease models associated with cytokine storm showed that this treatment provided substantial protection against not only sars-cov-2 infection, but also sepsis, hemophagocytic lymphohistiocytosis, and cytokine shock models, demonstrating the broad physiological relevance of this mechanism.