claim: the inhaled corticosteroid ciclesonide support coronavirus rna replication by targeting viral nsp15
evidence_1: within this library, ciclesonide, an inhaled corticosteroid, suppressed human coronavirus replication in cultured cells, but did not suppress replication of respiratory syncytial virus or influenza virus.", "after the eleventh consecutive mers-cov passage in the presence of ciclesonide, a resistant mutation was generated, which resulted in an amino acid substitution (a25v) in nonstructural protein (nsp) 15, as identified using reverse genetics.", "these observations suggest that the effect of ciclesonide was specific to coronavirus, suggesting this is a candidate drug for treatment of patients suffering mers or covid-19."
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  )