mood disorders like depression are schizophrenic symptoms that are decreased by drugs that selectively block the d2 dopamine receptor.
what schizophrenic symptoms are decreased by drugs that selectively block the d2 dopamine receptor?
mood disorders like depression
dopamine receptor d2









































dopamine receptor d, also known as d2r, is a protein that, in humans, is encoded by the "drd2" gene. after work from paul greengard's lab had suggested that dopamine receptors were the site of action of antipsychotic drugs, several groups (including those of solomon snyder and philip seeman) used a radiolabeled antipsychotic drug to identify what is now known as the dopamine d receptor. the dopamine d receptor is the main receptor for most antipsychotic drugs. the structure of drd2 in complex with the atypical antipsychotic risperidone has been determined.









































section::::function.
dopamine receptor d2
d1–d2 dopamine receptor heteromer









































the d–d dopamine receptor heteromer is a receptor heteromer consisting of d and d protomers.









































section::::structure.









































d and d receptors interact primarily through discrete amino acids in the cytoplasmic regions of each receptor, with no involvement of transmembrane parts. the intracellular loop 3 of the d receptor contains two adjacent arginine residues, while the carboxyl tail of the d receptor possesses two adjacent glutamic acid residues. the two receptors can form a heteromer complex via a salt bridge between the guanidine moiety and the carboxylic group.









































section::::signal transduction.
d1–d2 dopamine receptor heteromer