congenital inheritance is associated with sickle cell anemia.
what type of inheritance is associated with sickle cell anemia?
congenital
sickle cell disease (scd) is a group of blood disorders typically inherited from a person's parents. the most common type is known as sickle cell anaemia (sca). it results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells. this leads to a rigid, sickle-like shape under certain circumstances. problems in sickle cell disease typically begin around 5 to 6 months of age. a number of health problems may develop, such as attacks of pain ("sickle cell crisis"), anemia, swelling in the hands and feet, bacterial infections and stroke. long-term pain may develop as people get older. the average life expectancy in the developed world is 40 to 60 years.
sickle cell disease
"sickle cell anemia, a molecular disease" is a 1949 scientific paper by linus pauling, harvey a. itano, seymour j. singer and ibert c. wells that established sickle-cell anemia as a genetic disease in which affected individuals have a different form of the metalloprotein hemoglobin in their blood. the paper, published in the november 25, 1949 issue of "science", reports a difference in electrophoretic mobility between hemoglobin from healthy individuals and those with sickle-cell anemia, with those with sickle cell trait having a mixture of the two types. the paper suggests that the difference in electrophoretic mobility is probably due to a different number of ionizable amino acid residues in the protein portion of hemoglobin (which was confirmed in 1956 by vernon ingram), and that this change in molecular structure is responsible for the sickling process. it also reports the genetic basis for the disease, consistent with the simultaneous genealogical study by james v. neel: those with sickle-cell anemia are homozygous for the disease gene, while heterozygous individuals exhibit the usually asymptomatic condition of sickle cell trait.
sickle cell anemia, a molecular disease