 In the brain, noradrenaline is produced in nuclei that are small yet exert powerful effects on other brain areas.The most important of these nuclei is the locus coeruleus, located in the pons.Outside the brain, norepinephrine is used as a neurotransmitter by sympathetic ganglia located near the spinal cord or in the abdomen, and it is also released directly into the bloodstream by the adrenal glands.