 The main receptor for the shiga toxin is globotriaosylceramide or Gb3.Shiga toxin is also brought to the golgi apparatus before being directed to the endoplasmic reticulum for PDI to cleave the disulfide bond.Shiga toxin's A subunit is then brought back into the cytosol and inhibits eukaryotic protein synthesis with its RNA N-glycosidase activity by cleaving a specific adenine base on 28S ribosomal RNA that will ultimately cause cell death.