 In 1939, Hermann Blaschko and Peter Holtz independently identified the biosynthetic mechanism for norepinephrine in the vertebrate body.In 1945 Ulf von Euler published the first of a series of papers that established the role of norepinephrine as a neurotransmitter.He demonstrated the presence of norepinephrine in sympathetically innervated tissues and brain, and adduced evidence that it is the "sympathin" of Cannon and Rosenblueth.