 It is based on the statistical R programming language.The lumi package provides an analysis pipeline for probe-level Illumina expression and methylation microarray data, including probe-identifier management (nuID), updated probe-to-gene mapping and annotation using the latest release of RefSeq (nuIDblast), probe-intensity transformation (VST) and normalization (RSN), quality control (QA/QC) and preprocessing methods specific for Illumina methylation data.By extending the ExprSet object with Illumina-specific features, lumi is designed to work with other Bioconductor packages, such as Limma and GOstats to detect differential genes and conduct Gene Ontology analysis.