 APH-1

APH-1 (anterior pharynx-defective 1) is a protein gene product originally identified in the Notch signaling pathway in "Caenorhabditis elegans" as a regulator of the cell-surface localization of nicastrin.APH-1 homologs in other organisms, including humans, have since been identified as components of the gamma secretase complex along with the catalytic subunit presenilin and the regulatory subunits nicastrin and PEN-2.