 IGF2Rs from both the cell surface and the Golgi are trafficked to the early endosome where, in the relatively low pH environment of the endosome, the IGF2Rs release their cargo.The IGF2Rs are recycled back to the Golgi by the retromer complex, again by way of interaction with GGAs and vesicles.The cargo proteins are then trafficked to the lysosome via the late endosome independently of the IGF2Rs.