 It is found that the endocannabinoid anandamide and the cannabinoid, WIN 55,212-,2 can modify the overall response to sympathetic nerve stimulation, and indicate that prejunctional CB1 receptors mediate the sympatho-inhibitory action.Thus can cannabinoids inhibit both the noradrenergic and purinergic components of sympathetic neurotransmission.The noradrenergic neurons in the brain form a neurotransmitter system, that, when activated, exerts effects on large areas of the brain.