 The mnemonic "NOT RECLUSE" has been suggested as a tool to help professionals more objectively exclude skin lesions that were suspected to be loxosceles.Numerous (should be solitary), Occurrence (wrong geography) Timing (wrong season), Red Center (center should be black), Elevated (should be shallow depression), Chronic, Large (more than 10 cm), Ulcerates too quickly (less than a week), Swollen, Exudative (there should be no pus, it should be dry)

Despite being one of the few medically important spider bites, there is no established treatment for the bite of a Loxosceles spider.Physicians wait for the body to heal itself, and assist with cosmetic appearance.