 The second is an N-terminal Sac1-like inositol phosphatase domain, which, in vitro, can hydrolyze PIP and PIP2 to PI.The third is a C-terminal domain that is rich in the amino acid proline and interacts with several proteins also involved in vesicle endocytosis.Specifically, the c-terminal domain interacts with amphiphysin, endophilin, DAP160/intersectin, syndapin and Eps15.