 Jak1 as well as Stat1 are required for receptor phosphorylation, signaling transduction and induction of biological response.It is known, from different studies, that a scarcity of this homodimer or its receptor promotes colorectal cancer development.It was studied that synergistic activation mediator-derived (SAM) can cause a specified expression of interferon-gamma and, thus activates innate immunity and inhibits tumorgenesis.