 It was found that elevated expression of Timeless was significantly associated with more advanced tumor stage and poorer breast cancer prognosis.Similarity in gene expression signatures has allowed for TIMELESS to be identified as Kinase Suppressor of Ras-1 (KSR1)-like and a potential target required for cancer cell survival.TIMELESS overexpression represents a vulnerability in Ras-driven tumors that offers potential insight into novel and selective targets found in Ras-driven cancers, which can be leveraged to develop selective and more effective therapeutics.