 For instance, there are some CD4 Th1 cells that have low levels of IFNGR2 expression in their surface.This leads to a low expression or IFN-gamma receptor and consequently, to a functional blockade of IFN-gamma signaling.The intracellular domain contains binding motifs for Jak1 and the latent cytosolic factor, signal transducer and activator of transcription Stat1.