 In contrast to the pain associated with osteoid osteoma, the pain of osteoblastoma usually is less intense, usually not worse at night, and not relieved readily with salicylates (aspirin and related compounds).If the lesion is superficial, the patient may have localized swelling and tenderness.Spinal lesions can cause painful scoliosis, although this is less common with osteoblastoma than with osteoid osteoma.