 Reports disagree on the potencies of these metabolites with, for example, the most potent one, 9("S")-HODE, requiring at least 10 micromoles/liter.or a more physiological concentration of 10 nanomoles/liter to activate TRPV1 in rodent neurons.The TRPV1-dependency of these metabolites' activities appears to reflect their direct interaction with TPRV1.