 Toadshade is listed as state threatened in Michigan and state endangered in New York; both states are on the northern edge of its range.It is threatened by habitat fragmentation, deer browse, and invasive species such as Amur honeysuckle ("Lonicera maackii") and wild boar ("Sus scrofa").Although some accounts indicate that the cooked greens of this plant may be edible as an emergency food, the entire plant, and especially the root, is known to induce vomiting.