 While at Boston College, Guillemin did extensive research on hospital technology and medical ethics, receiving fellowships to work on the U.S. Senate Finance Committee staff and at the Hastings Center for the Study of Ethics.She was also co-head of the National Library of Medicine's HealthAware Project, a joint project with Harvard Medical School to test how the internet could be used to educate people about preventive health measures.She married Robert Guillemin and had two sons, Robert and John.