 Glucocorticoids, transforming growth factor-B, IL-4 and IL-10 are negative regulators for production of IFN-gamma.Once is IFN-γ is exposed, the main functions will be the activation of macrophages and the induction of Class II major histocompatibility complex (MHC) molecule expression.Nevertheless, IFN-γ is implicated in many function within immune system as immunoregulatory, antiviral and anti-tumor properties.