 Although relatively weak agonists of TRPV1 in comparison to anandamide, these linoleate metabolites have been proposed to act through TRPV1 in mediating pain perception in rodents and to cause injury to airway epithelial cells and thereby to contribute to asthma disease in mice and therefore possibly humans.Certain arachidonic acid metabolites, including 20-hydroxy-5"Z",8"Z",11"Z",14"Z"-eicosatetraenoic acid (see 20-Hydroxyeicosatetraenoic acid) and 12("S")-hydroperoxy-5"Z",8"Z",10"E",12"S",14"Z"-eicosatetraenoic acid (12(S)-HpETE), 12("S")-hydroxy-5"Z",8"Z",10"E",12"S",14"Z"-eicosatetraenoic acid (12("S")-HETE (see 12-HETE), hepoxilin A3 (i.e.8R/S-hydroxy-11,12-oxido-5Z,9E,14Z-eicosatrienoic acid) and HxB3 (i.e.