 N-Arachidonoyl dopamine, an endocannabinoid found in the human CNS, structurally similar to capsaicin, activates the TRPV1 channel with an EC50 of approximately of 50 nM.N-Oleyl-dopamine, another endogenous agonist, binds to human VR1 with an Ki of 36 Nm.Another endocannabinoid anandamide has also been shown to act on TRPV1 receptors.