 Published in 1900, the novel intimately traced the struggle of a woman addicted to morphine as she deteriorated physically and mentally.His best known written work, "De Kleine Johannes" ("Little Johannes"), which first appeared in the premiere issue of "De Nieuwe Gids", was a fantastical adventure of an everyman who grows up to face the harsh realities of the world around him and the emptiness of hopes for a better afterlife, but ultimately finding meaning in serving the good of those around him.This ethic is memorialized in the line "Waar de mensheid is, en haar weedom, daar is mijn weg."