 In addition, ciprofloxacin has also been shown to induce via the SOS response dissemination of virulence factors  and antibiotic resistance determinants, as well as the activation of integron integrases, potentially increasing the likelihood of acquisition and dissemination of antibiotic resistance by bacteria.Impaired LexA proteolysis has been shown to interfere with ciprofloxacin resistance.This offers potential for combination therapy that combines quinolones with strategies aimed at interfering with the action of LexA, either directly or via RecA.