 In 1865, Worthington was among the Cleveland businessmen who organized the Hahnemann Life Insurance Company (named for German physician Samuel Hahnemann), the first such firm in the U.S. to offer to insure those whose medical belief and practice were exclusively homeopathic, at lower rates than those subjecting themselves to traditional medical treatment; as some contemporary evidence showed a lower rate of mortality under the former.Worthington was also a director of the Ohio Savings and Loan Bank, for some years a director of the Cleveland, Columbus, Cincinnati & Indianapolis Railway Company, and was president of the Cleveland Iron Mining Company.He was also one of the pioneers in the development of the iron interests of Cleveland.