 Apart from a brief professional tour of the United States in 1857–58, the majority of Vezin's acting career took place on the English stage.Though primarily an actor, in 1866 he collaborated with the playwrights W. G. Wills and James Albery to write the vaudeville inspired play "Doctor Davey" based on the 1842 play "Le Docteur Robin" by French writer Jules de Prémaray in which he also played the title role.The following year he starred as a troubled Scottish poet James Harebell in Wills' "Man o' Airlie" (1867) to overwhelmingly positive reviews.