 The location for IRES elements is often in the 5'UTR, but can also occur elsewhere in mRNAs.IRES sequences were first discovered in 1988 in the poliovirus (PV) and encephalomyocarditis virus (EMCV) RNA genomes in the labs of Nahum Sonenberg and Eckard Wimmer, respectively.They are described as distinct regions of RNA molecules that are able to recruit the eukaryotic ribosome to the mRNA.