 LXA4 and 15-epi-LTA4 also act by mobilizing transcription factors that regulate expression of various inflammation-regulating genes.LXA4 stimulates various cell types to promote the entry of Nrf2 into the nucleus and thereby to increase the expression of genes such as heme oxygenase-1 (HMOX1), which increases production of the anti-inflammatory gaseous signaling agent, carbon monoxide, and genes involved in the synthesis of glutathione, a product which neutralizes oxidative stress and oxidant-induced tissue damage.Metabolically resistant structural analogs of LXB4 and 15-epi-LXA4 inhibit formation of Peroxynitrite (i.e.