 LXA4 and 15-epi-LXA4, when introduced by Intrathecal administration into rodents, suppress the perception of inflammatory pain; this action may involve the ALX/FPR receptor shown to be present on the spinal astrocytes of test animal and, based on studies using 15-epi-LXA, inhibition of the NALP1 inflammasome signaling complex.By mechanisms yet to be clearly identified, the two LX's also