 Lipoxin A4 enhance the affinity of anandamide at this receptor to exert cannabimimetic effects in the brain, by allosterically enhancing AEA signaling and thereby potentiating the effects of this endocannabinoid both in vitro and in vivo.In addition to this, lipoxin A4 display a CB1 receptor-dependent protective effect against β-amyloid-induced spatial memory impairment in mice.Relatively stable, i.e.