(ALOX5) in neutrophils and 15-lipoxygenase-1 (i.e.ALOX15) in immature erythrocytes and reticulocytes operate in series to form LxA44 and LxB44; this pathway also occurs in serial interactions between neutrophils and eosinophils; between epithelium or M2 Macrophages/monocytes and neutrophils; and endothelium or skeletal muscle and neutrophils.