 ONOO−) to attenuate the mobilization of NFκB and AP-1 transcription factors by reducing their accumulation in the nucleus of neutrophils, monocytes, and lymphocytes; NFκB and AP-1 increase expression of pro-inflammatory genes.The two LXBs also trigger activation of Suppressor of cytokine signaling proteins (see SOCS proteins) which, in turn, inhibit activation of STAT protein transcription factors which up-regulate many genes making pro-inflammatory products.LXA4 and 15-epi-LXA4 are also high affinity antagonists of the Cysteinyl leukotriene receptor 1 for which leukotrienes (LT) LTC4, LTD4, and LTE4 are agonists, i.e.