 Type II prodrugs are bioactivated extracelluarly, either in the milieu of GI fluids (Type IIA), within the systemic circulation and/or other extracellular fluid compartments (Type IIB), or near therapeutic target tissues/cells (Type IIC), relying on common enzymes such as esterases and phosphatases or target directed enzymes.Importantly, prodrugs can belong to multiple subtypes (i.e., Mixed-Type).A Mixed-Type prodrug is one that is bioactivated at multiple sites, either in parallel or sequential steps.