 This structural definition distinguishes them from other SPMs such as the resolvins, neuroprotectins, and maresins, which are metabolites of the omega 3 fatty acids, eicosapentaenoic acid or docosahexaenoic acid, as well as a range of metabolites derived from other PUFAs (see specialized pro-resolving mediators).All of these other SPMs have activities and functions similar, although not necessarily identical, to the lipoxins .Formation of LXs is conserved across a broad range of animal species from fish to humans.