 TET-mediated conversion of mC to hmC appears to disrupt the binding of 5mC-binding proteins including MECP2 and MBD (Methyl-CpG-binding domain) proteins, facilitating nucleosome remodeling and the binding of transcription factors, thereby activating transcription of those genes.EGR1 is an important transcription factor in memory formation.It has an essential role in brain neuron epigenetic reprogramming.