 Adverse effects have been found to be of a similar level between TCAs and SSRIs.The TCAs were developed amid the "explosive birth" of psychopharmacology in the early 1950s.The story begins with the synthesis of chlorpromazine in December 1950 by Rhône-Poulenc's chief chemist, Paul Charpentier, from synthetic antihistamines developed by Rhône-Poulenc in the 1940s.