 He made his major league debut against the New York Yankees on April 20, going 1-for-4 against Yankee pitcher Red Ruffing.This was the only game which featured both Williams and Lou Gehrig playing against one another.In his first series at Fenway Park, Williams hit a double, a home run, and a triple, the first two against Cotton Pippen, who gave Williams his first strikeout as a professional while Williams had been in San Diego.