 After various changes of fortune, the Carthaginians managed to besiege Syracuse itself, but were eventually pushed back by a pestilence.A treaty in 392 BC allowed Syracuse to enlarge further its possessions, founding the cities of Adranon, Tyndarion and Tauromenos, and conquering Rhegion on the continent.In the Adriatic, to facilitate trade, Dionysius the Elder founded Ancona, Adria and Issa.