 A very small number of cases involving non-medical use of antidepressants have been reported over the past 30 years.According to the US government classification of psychiatric medications, TCAs are "non-abusable" and generally have low abuse potential.Nonetheless due to their atypical MOA, amineptine and tianeptine (dopamine reuptake inhibition and μ-opioid receptor agonism, respectively) are the two TCAs with the highest addiction and abuse potential.