 While the steady-state experiment is useful in many cases, it can only provide information on relative internuclear distances.On the other hand, the initial "rate" at which the NOE grows is proportional to "r"IS−6, which provides other more sophisticated alternatives for obtaining structural information via transient experiments such as 2D-NOESY.The motivations for using two-dimensional NMR for measuring NOE's are similar as for other 2-D methods.