 The agency's toxicology work involves pharmacokinetic/pharmacodynamic modeling, quantitative structure–activity relationship methods, and benchmark dose modeling, as well as establishing minimal risk levels for human exposure to hazardous substances.One model developed by the toxicology laboratory showed that children were much more susceptible than adults to chemical exposure from inhalation and oral exposure.In the aftermath of chemical spills and emergencies, the laboratory also conducts research for state and local health departments on the health effects of the chemicals involved.