 In this example, the proton designated as {H} shows two different sets of NOEs depending on the isomerization state ("cis" or "trans") of the switchable azo groups.In the "trans" state proton {H} is far from the phenyl group showing blue coloured NOEs; while the "cis" state holds proton {H} in the vicinity of the phenyl group resulting in the emergence of new NOEs (show in red).Another example (bottom) where application where the NOE is useful to assign resonances and determine configuration is polysaccharides.