 Clinical cases of patients with this condition display a range of symptoms.The most relevant abnormality of HED is hypohidrosis, the inability to produce sufficient amounts of sweat, which is attributed to missing or dysfunctional sweat glands.This aspect represents a major handicap particularly in the summer, limits the patient's ability to participate in sports as well as his working capacity, and can be especially dangerous in warm climates where affected individuals are at risk of life-threatening hyperthermia.