 The suppressor immune cells are not affected by GRMF, so the immune cells' effective setpoint may be even higher than the setpoint for physiological processes.GRMF affects primarily the liver (rather than the kidneys) for some physiological processes.High-potassium media (which stimulates aldosterone secretion "in vitro") also stimulate cortisol secretion from the fasciculata zone of canine adrenals — unlike corticosterone, upon which potassium has no effect.