 Maintaining an electric field in an electrolyte requires Faradaic reactions to occur at the anode and cathode.This is typically electrolysis of water, which generates hydrogen peroxide, hydrogen ions (acid) and hydroxide (base) as well as oxygen and hydrogen gas bubbles.The hydrogen peroxide and/or pH changes generated can adversely affect biological cells and biomolecules such as proteins, while gas bubbles tend to "clog" microfluidic systems.