 The "CLCN5" gene has 8 paralogues ("CLCN1", "CLCN2", "CLCN3", "CLCN"4, "CLCN6", "CLCN7", "CLCNKA", "CLCNKB") and 201 orthologues among jawed vertebrates ("Gnathostomata").Five different "CLCN5" gene transcripts have been discovered, two of which (transcript variants 3 [NM_000084.5] and 4 [NM_001282163.1]) encode for the canonical 746 amino acid protein, two (transcript variants 1 [NM_001127899.3] and 2 [NM_001127898.3]) for the NH2-terminal extended 816 amino acid protein and one does not encode for any protein (Transcript variant 5, [NM_001272102.2]).The 5’ untranslated region (5’UTR) of "CLCN5" is complex and not entirely clarified.