 On 26 May 1853, Frederick married Alexandra's first cousin, Princess Anna of Prussia (1836–1918), at Charlottenburg Palace in Berlin.Although they had six children together, Frederick and Anna were never emotionally close, and it is speculated that one reason was because Fritz was unable to overcome his grief for his first wife.His first wife was Alexandra Nikolaevna of Russia (1825–1844), daughter of Emperor Nicholas I of Russia and Charlotte of Prussia.