 Consequently, the loss of B-cell differentiation in Hodgkin's lymphoma may be due to CD99 downregulation.Men appear to express higher levels of CD99 than women.In patients with diffuse large B-cell lymphoma (DLBCL) with the germinal center B-cell (GCB, classified according to the Muris algorithm) subtype, positive expression of CD99 resulted in better 2-year event free survival (EFS) and 2-year overall survival (OS) compared to negative expression of CD99.