 The marriage was celebrated in person at Thonon in Chablais on 20 August 1724.Her stepson Victor Amadeus, heir after his father and grandfather to the Sardinian crown, died at the age of two, a year after Polyxena's marriage and before she had a child of her own.Nonetheless, she is said to have had a close relationship with her mother-in-law, Anne Marie d'Orléans, and the two frequented the "Villa della Regina" outside the capital, where the latter died in 1728.