 A novel domain may exist in the SAGs that is separate from the TCR and class II MHC-binding domains.The domain consists of residues 150 to 161 in SEB, and similar regions exist in all the other SAGs as well.In this study a synthetic peptide containing this sequence was able to prevent SAG-induced lethality in D-galactosamine-sensitized mice with staphylcoccal TSST-1, as well as some other SAGs.