 In human, TLR6 is highly expressed in appendix, spleen and lymph node.Among the immune cells, TLR6 has been detected in conventional dendritic cells, monocytes, macrophages, microglia, neutrophils, NK cells and B lymphocytes.A 359T>C single-nucleotide polymorphism (SNP) in the extracellular leucine rich repeat domain is associated with susceptibility to Legionnaires’ Disease.