 RhoA has also been found to be hyper activated in gastric cancer cells; in consequence, suppression of RhoA activity partially reversed the proliferation phenotype of gastric cancer cells via the down-regulation of the RhoA-mammalian Diaphanous 1 pathway.Doxorubicin has been referred to frequently as a highly-promising anti-cancer drug that is also being utilized in chemotherapy treatments; however, as with nearly all chemotherapeutics, the issue of drug resistance remains.Minimizing or postponing this resistance would the necessary dose to eradicate the tumor, thus diminishing drug toxicity.