 Seeds are thinner and more elongated than those of the closely related species "Desmanthus illinoensis".Root bark of "D. leptolobus" has been found to contain a psychedelic compound called N,N-DMT and other related tryptamines.While its only reported quantitative analysis found concentrations of 0.14% of N,N-DMT (lower than has been found in "Desmanthus illinoensis"), one person documented a "subjectively stronger response" than "D. illinoensis".