 A major function for FPR2 is binding certain specialized pro-resolving mediators (SPMs), i.e.lipoxin (Lx)A4, and AT-LxA4 (metabolites of arachidonic acid) as well as resolvin D1 (RvD)1, RvD2, and AT-RvD1 (metabolites of docosahexaenoic acid) and thereby to mediate these metabolites activities in inhibiting and resolving inflammation (see Specialized pro-resolving mediators).However, FPR2 also mediates responses to a wide range of polypeptides and proteins which may serve to promote inflammation or regulate activities not directly involving inflammation.