 Glaucoma-associated mutations activate that signal sequence and direct myocilin to peroxisomes, where they accumulate in the cell, instead of being secreted.Decreased secretion and increased accumulation appear to be the initial steps in myocilin-associated glaucoma.A study employing iterative pocket & ligand-similarity based approach to virtual ligand screening predicted small molecule binders for the olfactomedin domain of human myocilin.