 RhoA specifically is regarded as a prominent regulatory factor in other functions such as the regulation of cytoskeletal dynamics, transcription, cell cycle progression and cell transformation.The specific gene that encodes RhoA, "RHOA", is located on chromosome 3 and consists of four exons, which has also been linked as a possible risk factor for atherothrombolic stroke.Similar to other GTPases, RhoA presents a Rho insert in its primary sequence in the GTPase domain.