 King Victor Amadeus II of Sardinia approached her family and proposed a union between Polyxena and Victor Amadeus II's son and heir, Charles Emmanuel, Prince of Piedmont.A previous match orchestrated by Agostino Steffani with a daughter of Rinaldo d'Este, Duke of Modena, had come to nothing.His first wife, Countess Palatine Anne Christine of Sulzbach, died on 12 March 1723, less than a year after her marriage and barely a week after giving birth to a son, Victor Amadeus, Duke of Aosta (7 March 1723 – 1 August 1725).