 Tight ends coach Dan Campbell was named the interim head coach for the remainder of the season.In Week 6, Grimes made a season-high four pass deflections, two combined tackles, and intercepted a pass by Marcus Mariota in a 38–10 victory at the Tennessee Titans.On November 8, 2015, Grimes collected a season-high seven solo tackles in the Dolphins' 33–17 loss to the Buffalo Bills in Week 9.