 In 1906 he became a professor of pathology at the medical academy in Düsseldorf, and afterwards worked as a pathologist in Zurich and Marburg.In 1913 he succeeded Richard Kretz (1865-1920) as professor of pathology at the University of Würzburg, a position he maintained until his retirement in 1934.Schmidt specialized in pathological investigations of bone disorders such as rickets, osteogenesis imperfecta, and osteomalacia.