 It is necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3.In addition, it may also act as scaffold protein in the nucleus.This regulatory protein (factor) interacts with a sodium/hydrogen exchanger NHE3 (SLC9A3) in the brush border membrane of the proximal tubule, small intestine, and colon that plays a major role in transepithelial sodium absorption.