 Though RhoA is most easily recognized from its unique contributions in actin-myosin contractility and stress fiber formation, new research has also identified it as a key factor in the mediation of membrane ruffling, lamellae formation and membrane blebbing.A majority of this activity occurs in the leading edge of cells during migration in coordination with membrane protrusions of breast carcinoma.Molecules act on various receptors, such as NgR1, LINGO1, p75, TROY and other unknown receptors (e.g.