 TSST-1 is also different from other PTSAgs in its ability to cross mucous membranes, which is why it is an important factor in menstrual TSS 
When the protein is translated, it is in a pro-protein form, and can only leave the cell once the signal sequence has been cleaved off.The "explagr" locus is one of the key sites of positive regulation for many of the "S. aureus" genes, including TSST-1.Additionally, alterations in the expression of the genes "ssrB" and "srrAB" affect the transcription of TSST-1.