 When King Victor Amadeus announced his decision to return to the throne after having abdicated in 1730, Polyxena used her influence over her husband to have his father imprisoned at the Castle of Moncalieri, where he was joined for a while by his morganatic wife, Anna Canalis di Cumiana, Polyxena's former lady of the bedchamber.In an 1869 history of the House of Savoy, Francesco Predari wrote that despite the fact Polyxena was praised for goodness of character and beautiful virtues, her father-in-law advised her to take care to maintain separate quarters from her husband for prudence's sake.In 1732 she founded a home for young mothers in Turin, redecorated the "Villa della Regina", Stupinigi's hunting lodge, and the Church of Saint Joseph in Turin.