 The following week, Grimes collected a season-high nine solo tackles, a pass deflection, and an interception during a 31–3 win against the Buffalo Bills in Week 16.On December 29, 2009, it was announced that Grimes was selected to be an alternate for the 2010 Pro Bowl.On January 3, 2010, Grimes made two solo tackles, a season-high three pass deflections, and intercepted a pass by Josh Freeman in a 20–10 victory at the Tampa Bay Buccaneers in Week 17.