 On December 19, 2010, Grimes recorded five pass deflections, three solo tackles, and an interception in a 34–18 win at the Seattle Seahawks in Week 15.Grimes earned NFC Defensive Player of the Week for his performance.He recorded a career-high 87 combined tackles (76 solo), 23 pass deflections, and five interceptions in 16 games and 16 starts.