 Additionally, by tracking mitochondria amounts and quality, they found that BNIP3 is necessary for clearing dysfunctional mitochondria with low membrane potential and reducing the build up of ROS to promote cell survival.BNIP3L was also tested and was found to play a nonredundant role in cell survival.Various stimuli like decreased intracellular pH, increased cytosolic calcium concentrations, and other toxic stimuli can induce BNIP3 integration into the outer mitochondrial membrane (OMM).