 CUL4A regulates numerous key processes such as DNA repair, chromatin remodeling, spermatogenesis, haematopoiesis and the mitotic cell cycle.As a result, CUL4A has been implicated in several cancers and the pathogenesis of certain viruses including HIV.A component of a CUL4A complex, Cereblon, was discovered to be a major target of the teratogenic agent thalidomide.