 On November 15, 2019 the US Food and Drug Administration approved Adakveo® (crizanlizumab), previously known as SEG101, to reduce the frequency of vaso-occlusive crises (VOCs), or pain crises, in adult and pediatric patients aged 16 years and older with sickle cell disease.Tetherex Pharmaceuticals Corporation, formed in 2014 and also based in Oklahoma City, is a spin-off of Selexys.Tetherex develops novel first-in-class therapeutics targeting cell adhesion proteins in inflammatory, thrombotic and oncologic diseases, and its lead drug is a function-blocking anti-PSGL-1 antibody called SelK2, initially under development for the treatment of Crohn's disease and venous thromboembolism.