 LHX2, a LIMtype homeoprotein, is a protein partner for MSX1 in vitro and in cellular extracts.The interaction between MSX1 and LHX2 is mediated through the homeodomain-containing regions of both proteins.MSX1 and LHX2 form a protein complex in the absence of DNA, and that DNA binding by either protein alone can occur at the expense of protein complex formation.