 In the brain the role of PCSK9 is still controversial and may be either pro-apoptotic or protective in the development of the nervous system.PCSK9 levels have been detected in the cerebrospinal fluid at a 50-60 times lower level than in serum.A multi-locus genetic risk score study based on a combination of 27 loci including the PCSK9 gene, identified individuals at increased risk for both incident and recurrent coronary artery disease events, as well as an enhanced clinical benefit from statin therapy.