 Model organisms have been used in the study of ANXA6 function.A conditional knockout mouse line, called "Anxa6tm1a(EUCOMM)Wtsi" was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.