 Lyn has been described to have an inhibitory role in myeloid lineage proliferation.Following engagement of the B cell receptors, Lyn undergoes rapid phosphorylation and activation.LYN activation triggers a cascade of signaling events mediated by Lyn phosphorylation of tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the receptor proteins, and subsequent recruitment and activation of other kinases including Syk, phosholipase Cγ2 (PLCγ2) and phosphatidyl inositol-3 kinase.