 HPV infection inhibits the expression of TLR9 in keratinocytes, abolishing the production of IL-8.However inhibition of TLR9 by oncogenic viruses is temporary, and patients with long-lasting HPV actually show higher levels of TLR9 expression in cervical cells.In fact, the increase in expression is so severe that TLR9 could be used as a biomarker for cervical cancer.