 In 1907 she was appointed assistant bacteriologist at Danvers State Hospital in Massachusetts, where she met Elmer Ernest Southard, Bullard Professor of Neuropathology at Harvard Medical School, who encouraged her interest in neuropathology.In 1910 she became resident pathologist at Boston State Hospital and in 1914 was appointed pathologist to the Massachusetts Department of Mental Diseases.She was also an instructor of neuropathology at the University of Vermont.