 Simian virus 5 and type II human parainfluenza virus express a protein, named "V", which acts as a substrate receptor and bridges an interaction between DDB1 and STAT proteins (the structure of the CRL4ASV5V complex is pictured in the inset) - thus inducing STAT1 ubiquitination and degradation

DCAF1 is also named VPRBP due to its interaction with HIV-1 protein Vpr.Although DCAF1/VPRBP appears to have a crucial function in tumor suppression, DNA replication and embryonic development, HIV-1 "hijacks" the ubiquitin ligase complex to induce arrest of the cell cycle in G2 phase.The CRL4ADCAF1-Vpr induces ubiquitination of the nuclear isoform of uracil-DNA glycosylase.