 Deletion of the paternal allele of GABRB3 has no known implications with this syndrome, while deletion of the maternal GABRB3 allele results in development of the syndrome.There is a strong association between GABRB3 expression levels and proper palate development.A disturbance in GABRB3 expression can be lined to the malformation of nonsyndromic cleft lip with or without cleft palate.