 As many studies involving aloe gel (without aloin) have not observed these negative effects, it is possible that the negative effects could in large part be due to aloin.Plant-derived remedies containing aloin and other anthraquinones have been used as traditional medicines since antiquity, but harsh side effects make aloin generally unsuitable for household or daily use.In 2002, the US FDA mandated that manufacturers reformulate or stop manufacturing over-the-counter products containing aloe because the agency did not receive necessary safety data.