 NONO binds to SFPQ to form a heterodimer that interacts with the MATR3 protein.The interaction of these three proteins may be part of the process in the nucleus that is responsible for the retention of RNAs that are defective, not yet mature enough to be exported or are designed to be retained in nucleus.NONO protein (Human) is encoded by the NONO gene which is located on the plus strand of the X chromosome.