 Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor.At least 16 distinct subunits of GABA-A receptors have been identified.The GABRA1 receptor is the specific target of the z-drug class of nonbenzodiazepine hypnotic agents and is responsible for their hypnotic and hallucinogenic effects.