 It was found that RASSF1A was silenced in cancer cells when the promoter region was hypermethylated.It is speculated that cancer subtypes may develop due to the inverse relationship of RASSF1A and HPV.RASSF1A promoter hypermethylation and oncogenic HPV were detected in ACs, but SCCs displayed a high level of HPV DNA and no RASSF1A promoter methylation.