 Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome.Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.Caspase 10 has been shown to interact with FADD, CFLAR, Caspase 8, Fas receptor, RYBP, TNFRSF1A and TNFRSF10B.