 The problem is that this herbicide has been utilized for about 20 years and now some plants have now emerged that are glyphosate-resistant.This has relevance to research on shikimate dehydrogenase because it is important to maintain diversity in the enzyme blocking process in the shikimate pathway and with more research shikimate dehydrogenase could be the next enzyme to be inhibited in the shikimate pathway.In order to design new inhibitors the structures for all the enzymes in the pathway have needed to be elucidated.