 ROCK1 is a major downstream effecter of the small GTPase RhoA and is a regulator of the actomyosin cytoskeleton which promotes contractile force generation.ROCK1 plays a role in cancer and in particular cell motility, metastasis, and angiogenesis.ROCK1 is also the name of the gene that encodes the protein ROCK1, a serine/threonine kinase.