 Nicotinate dehydrogenase

In enzymology, a nicotinate dehydrogenase () is an enzyme that catalyzes the chemical reaction

nicotinate + H2O + NADP+ formula_1 6-hydroxynicotinate + NADPH + H+

The 3 substrates of this enzyme are nicotinate, H2O, and NADP+, whereas its 3 products are 6-hydroxynicotinate, NADPH, and H+.This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH2 groups with NAD+ or NADP+ as acceptor.