 This is an essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription.In the SCF complex, it serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits.May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.