 Hydroxypyruvate is still able to bind to the active site due to extra stabilization from hydrogen bonds with neighboring amino-acid residues.Glyoxylate reductase/Hydroxypyruvate reductase (GRHPR) is the glycerate dehydrogenase found, predominantly in the liver, of humans encoded by the gene GRHPR.Under physiological conditions, the production of D-glycerate is favored over its consumption as a substrate.