 Phosphorylation of the Ser50 residue has also been shown as a point of allosteric regulation of PTP1B, in which the phosphorylated state of the enzyme is inactive.PTPN1 has been shown to interact with BCAR1, epidermal growth factor receptor, Grb2 and IRS1.Vascular endotheliar growth factor Receptor-2  and Vascular endothelial growth factor via PGC1-alpha/ERR-alpha

PTP1B has clinical implications in the treatment of type 2 diabetes as well as cancer.