 In 2010, The US Census Bureau recorded the population of the region at 253,399, a growth rate of 11.0%.The most populous county in the region is Highlands County, and the region's largest cities are Avon Park and Sebring, both with slightly more than 10,000 people.Unlike the coastal areas to the east and west, the rural nature of the Florida Heartland is culturally closer to the Deep South than the rest of South Florida and has traditionally been inhabited by Americans of predominately English ancestry.