 The heart is developed asymmetrically using the left-right patterning induced by Cerberus which creates a higher concentration of signaling molecules on the left side.Experiments that inhibited Cerberus led to a loss of left-right polarity of the heart, which was shown by bilateral expression of left side-specific genes.During mammalian heart induction, a mammalian homologue, Cer1, is associated with the coordinated suppression of the TGFbeta superfamily members Nodal and BMP.