 SR 100 begins at an intersection with US 27 Alt./SR 18/SR 41/SR 109 in Greenville in Meriwether County.Moving north, SR 100 travels concurrent with SR 54 just east of the interchange with Interstate 85 (I-85) east of Hogansville.Once in Hogansville, SR 100 turns north concurrent with US 29/SR 14 for a short distance before continuing northwest alone.