 The polyadenylate RNA adopts an extended conformation running the length of the molecular trough.Adenine recognition is primarily mediated by contacts with conserved residues found in the RNP motifs of the two RRMs.In vitro studies have shown the binding affinities to be on the order of 2-7nM, while affinity for poly(U), poly(G), and poly(C) were reportedly lower or undetectable in comparison.