 TC1 is transported to the cell membrane by intracellular vesicles via microtubules.Mutations in the "SLC19A2" gene can cause thiamine-responsive megaloblastic anemia syndrome (TRMA), which is an autosomal recessive disease characterized by megaloblastic anemia, diabetes mellitus, and sensorineural deafness.Onset is typically between infancy and adolescence, but all of the cardinal findings are often not present initially.