 The journal was established by Arthur Fernandez Coca in 1916 as the official journal of the American Association of Immunologists and the New York Society for Serology and Hematology.Coca was sole editor from 1916 to 1925 when John C. Torrey joined the journal.From 1916 to 1925 the journal was published every 2 months, from 1926 to 1985 (except in 1928) it was published monthly.