 Though adrenocortical adenomas are considered challenging to differentiate from the normal adrenal cortex, they appear as well-circumscribed lesions once isolated.Imaging Diagnostics


 
Laboratory Tests


(may have focal dark regions corresponding to hemorrhage, lipid-depletion, and increased lipofuscin)

The microscopic histopathology analysis of the tissue samples obtained from the adrenal cortex of individuals presenting with adenoma-associated symptoms such as primary aldestronism (PA) indicates that adenoma cells are relatively larger with different cytoplasm, and increased variation in nuclear size.This indication is based on comparison between the healthy (normal) and affected (adenoma-associated) adrenal cortex tissue samples.