 He was the son of the second priest Hor-wer in Qus, Nu; his mother was a woman called Henutiry, Tiiry.Sennefer is called "son of the sister" of Ahmose Humay, a male royal nurse, brother to Amenhotep II's vizier Amenemopet , and married to the royal nurse Sentnay.His elder daughter Muttuy apparently married Kenamun, who succeeded Sennefer as mayor of Thebes.