 FGFR3 mutations are also linked with spermatocytic seminoma, which occur more frequently in older men.Defects in the FGFR3 gene has been associated with several conditions, including craniosynostosis and seborrheic keratosis.Mutations of FGFR3, FGFR3–TACC3 and FGFR3–BAIAP2L1 fusion proteins are frequently associated with bladder cancer, while some FGFR3 mutations are also associated with a better prognosis.