 During the Second Battle of Homs between the Mamluks and the Ilkhanids in October 1281, Isa commanded the right flank of the Mamluk army.Under his command were the horsemen of Al Fadl, Al Mira and Banu Kilab among other Syrian tribes.During the course of the battle, the Mamluk right held firm against the Ilkhanid right's assault and then the Mamluk divisions (excluding Isa's right flank) led a joint counterattack against the Ilkhanid right.