 In 2001, Bhandari joined John Kuriyan laboratory at the University of California, Berkeley as a post-doctoral fellow to work on the structural biology and biochemistry of proteins involved in cell signaling.In 2003, Bhandari relocated to the Johns Hopkins School of Medicine in Baltimore, where she worked with Solomon Snyder on deciphering the role of inositol pyrophosphates as signalling molecules.In 2015, a group led by Bhandari found that mice with lower levels of IP7 show reduced blood clotting.