 Neocentromeres have also been reported in lung carcinoma and acute myeloid leukemia.It may be worth noting that neocentromeres in cancer may occur more frequently than currently observed, because many cancer screenings involving karyotyping do not use assays that detect neocentromere formations.Although not discussed explicitly in relation to neocentromeres, it is worth noting that the breakage-fusion-bridge cycle involves ring chromosomes too.