 This mechanism is relevant when used as a means to decrease hypertension or increase bone mineral density

An understanding of proper dosage is needed in order to design an effective intermittent hypoxia protocol, particularly due to the comorbidities associated with hypoxia.For example, intermittent hypoxia has been shown to induce LTF in rats while continuous hypoxia does not.And acute IH shows no evidence of the hippocampal cell death found in rats while chronic intermittent hypoxia exposure does

Though intermittent hypoxia has been used for various therapeutic applications across a number of physiological system, there is a general consensus in what can be considered a safe and beneficial amount of intermittent hypoxia.