 Taking into account that only fewer than 5% of Turner syndrome cases are mosaic, one may consider, likewise with neocentromere assays in cancer, that neocentromeres may occur at a higher frequency in mosaic Turner syndrome than observed.As aforementioned, the formation of the centromere is well known to be regulated epigenetically.However, those epigenetic mechanisms are still debated contentiously; fortunately, neocentromeres provide a model system for studying different proposed mechanisms.