 Findings in model organisms, namely inducing neocentromerization in chicken and fungal systems, have brought up a few more correlations for thought.Specifically, in chicken DT40 cells, it was found that neither histone modifications nor early replication timing is associated with neocentromere formation.Moreover, it was also found that neocentromeres form on both transcriptionally active and inactive loci, challenging the widely accepted notion that centromeres do not appear on coding regions of the chromosome.