 It was also in 1987 when he started his private law practice.In his 40 years of law practice, he served as the defense lawyer of prominent politicians such as Datu Unsay Mayor Andal Ampatuan Jr. who was implicated in the 2009 Maguindanao massacre, Calauan Mayor Antonio Sanchez who was tried for the 1993 Eileen Sarmenta and Allan Gomez murder, and the family of former President Ferdinand Marcos in relation to recovering their ill-gotten wealth.Panelo also lawyered for former Commission on Elections Chairman Benjamin Abalos who was embroiled in the 2007 elections scandal, Philip Medel who was convicted in the murder of actress Nida Blanca, and the family of slain racing champion Enzo Pastor.