 By 2008, more than 90 reported cases of human neocentromeres were detected on marker chromosomes that experienced a loss of centromere, and a subsequent rearrangement.Common traits among these human neocentromeres include being analphoid, staining C-band negative, containing a primary constriction site, and binding to essential centromere proteins that signal the presence of a kinetochore.Neocentromeres have been detected in human cancers, even though the observed frequency of neocentromeres in the population is relatively low.