 Holocentromeres serve as model comparisons to neocentromeres because holocentromeres have seemingly arbitrary “seeds” of CENPA distributed throughout the chromosome, which work together to make a functional kinetochore.It is important to note that these CENPA seeds are excluded from genes or loci that are transcribed in the germline or early embryo.This leads to the thought that the seemingly random scattering of these seeds is not inherited, and that each generation or meiosis has its own distinct scatter.