 There is a strong correlation between neocentromeres and a specific class (ALP-WDLPS) of lipomatous tumors.It has been observed that lipomatous tumors with alphoid sequences in the centromere are more aggressive and metastatic.Hence, one suggestion is that neocentromeres may quickly evolve into a centromere with alpha satellite but the correlation between repetitive sequence and aggressiveness of tumors remains unclear.