 The drug sulphetrone was introduced at Fantome Island in December 1948 in the treatment of 40 selected cases.Sulphone drugs such as dapsone and sulphetrone had side effects including anaemia, gastro-intestinal complaints and "dapsone syndrome" which could include dizziness, nausea, swelling of limbs and face, nodules under the skin and shivering attacks.However, in most cases the drugs worked.