 Such a protocol would involve a fraction of inspired oxygen ("Fi"O2) ranging between 0.09 – 0.16 with 3 – 15 episodes per day with comorbidities found in the range of a "Fi"O2 of 0.03 – 0.08 and 48 – 2400 episodes per day.Though intermittent hypoxia is initially involved with only the respiratory system, its downstream effects allow it to also be used as an effective rehabilitative intervention in a number of different biological systems in both animals and humans.For the respiratory system, the LTF facilitated by intermittent hypoxia aids in increasing phrenic motor nerve output.