 On 27 June 1583, Francesco D'Afflitto was appointed during the papacy of Pope Gregory XIII as Bishop of Scala.On 13 November 1583, he was consecrated bishop by Giulio Rossino, Archbishop of Amalfi, with Giovanni Bernardino Grandopoli, Bishop of Lettere-Gragnano, and Giovanni Agostino Campanile, Bishop of Minori, serving as co-consecrators.He served as Bishop of Scala until his death on 11 October 1593.