 2015–16 USC Upstate Spartans women's basketball team

The 2015–16 USC Upstate Spartans women's basketball team will represent the University of South Carolina Upstate in the 2015–16 NCAA Division I women's basketball season.The Spartans, led by eleventh year head coach Tammy George, played their games at G. B. Hodge Center and are members of the Atlantic Sun Conference.