 The biggest blow against the cartel was dealt by Colonel Ramírez (later Brigadier General) on March 7, 1984 in an operation involving the DEA to locate and destroy a large cocaine production camp in the jungle of the Yari River (between the departments of Caqueta and Meta) known by the cartel as "Tranquilandia" (the "Tranquil Land").It triggered direct hostilities by the cartel against the Colombian State, commencing with the murders of Minister Lara Bonilla on April 30, 1984 and Colonel Jaime Ramírez Gómez two years later.The importance of Ramírez's fight against the drug traffickers has been highlighted years after his murder, due to the damage caused by drug cartels to both Colombian and international communities.