 Many subsequent solvents systems were made with chloroform, methanol, and water which is sometimes represented as a ChMWat solvent system.Solvent systems formulated with "n"-butanol, water and a modifier such as acetic acid, pyridine or "n"-propanol have also enjoyed some success in DCCC.In some cases, non-aqueous biphasic solvent systems such as acetonitrile and methanol have been utilized.