 After Damiana's death in 1614, the mayorazgo passed to his son Alonso Nelli.The economic prosperity of the city -consequence of this close relation with the Crown-, that since the 12th century had conceded the first fairs, attracted to the city wealthy families of merchants and bankers.Fabio Nelli de Espinosa, son of the banker sienés Alfonso Nelli, was born in Valladolid, but the family businesses at a time of booming trade with America brought him outside his hometown until 1576, date of his definitive return and in which he ordered the construction of his residence.