 Should the diet, behavior, or a toxic environmental exposure continues across generations, the epigenetic modification will manifest in each generation.Such environmentally induced epigenetic state(s) can be reversed by removal or alteration of the factor, addition of a different environmental factor, or emigration from the contaminated site.Another form of epigenetic modification may occur when the change in the epigenome is incorporated into the germline, a process Dr. Crews has termed germline-dependent epigenetic change.