 In "Drosophila", the glypican "dally" assists diffusion of the BMP-family growth-promoting morphogen Decapentaplegic in the developing wing, while the developing haltere lacks "dally" and remains small.Extracellular localization of the other glypican in "Drosophila", "dally-like", is also required for the proper level of Hedgehog signaling in the developing wing.In humans, glypican-1 is overexpressed in breast and brain cancers (gliomas), while glypican-3 is overexpressed in liver cancers.