 Cesarini was born in Senigallia, near Ancona, in the Italian region of Marche, but when he was only a few months old he and his family emigrated to Buenos Aires, in Argentina.In his early career he played for several clubs around the Buenos Aires area, during the amateur era in Argentine football, most notably Chacarita Juniors.Cesarini was signed by Italian giants Juventus in 1929, he made his debut against S.S.C.