 It isn't, however, completely destroyed; part of the protein survives and acts as a repressor in the nucleus, keeping genes responsive to the Hedgehog signal silent.The degradation of Ci protein depends on a large multiprotein complex, which contains a serine/threonine kinase of unknown function, an anchoring protein that binds to microtubules (to keep the Ci protein out of the nucleus) and an adaptor protein.When the Hedgehog signaling pathway is turned on, the Ci proteolysis is suppressed and the unprocessed CI protein enters the nucleus, where it activates the transcription of its target genes.