 The observed enzyme imbalance in these tumors shows that an increased capacity for the synthesis of serine is coupled to its utilization for nucleotide biosynthesis as a part of the biochemical commitment to cellular replication in cancer cells.This pattern is found in sarcomas and carcinomas, and in tumors of human and rodent origin Thus, SDH is significant in the development of hyperglycemia and tumors.In addition, homocystinuria is a hereditary disease caused by the deficiency of L-serine dehydratase.