 These EBV+ B cells have numerous non-malignant crippling mutations, often proliferate excessively, and in some cases may transform into EBV+ B cell lymphomas.The other cell types in these infiltrates, including the malignant TFH cells, are EBV negative.While the World Health Organization (2016) has classified these EBV-associated cases as one of the Epstein-Barr virus-associated lymphoproliferative diseases (see EBV+ angioimmunoblastic T cell lymphoma, the role of the virus in the development and/or progression of EBV+ angioimmunoblastic T cell lymphoma is unclear.