 Rothberg and his wife Bonnie, a physician who also holds a Ph.D. in epidemiology from Yale, have five children, whom Rothberg often refers to in his speeches.in 2002, The couple started the nonprofit Rothberg Institute for Childhood Diseases which works on treatments for tuberous sclerosis, a rare disease that affects one of their children.The institute ran a distributed computing project called Community TSC until April 2009.