 The analysis of the 966 bp nucleotide sequence showed that the gene encoding beta-lactamase CfxA3 in "C. ochracea" E201 differs from cfxA gene of "B. vulgatus" by substitution of two amino acids (K272E and Y239D) and from cfxA2 gene of "P. intermedia" by a substitution of one amino acid (Y239D).CfxA3 was different from CfxA2 because of an aspartic acid in place of tyrosine (at position 239) and from CfxA because of a glutamic acid instead of a lysine (at position 272).In 2005, Handal et al.