 The creek acquired its name from the rather gruesome battles of the area in the 1750s during the French and Indian War, as well as from the many travelers who were killed by the Indians who had a settlement on the site of the town eventually named after the creek.Bloody Run was laid out on June 15, 1795, by Michael Barndollar, who purchased which included the Bloody Run creek.This early town was named Waynesburg in honor of George Wayne, but the post office bore the title of Bloody Run.