 It attributed the term "nanozyme"s to "analogy with the activity of catalytic polymers (synzymes)", based on the "outstanding catalytic efficiency of some of the functional nanoparticles synthesized".The term was coined the previous year by Flavio Manea, Florence Bodar Houillon, Lucia Pasquato, and Paolo Scrimin.In 2006, nanoceria (i.e., CeO2 nanoparticles) was reported as observed, in rat experiments, preventing retinal degeneration induced by intracellular peroxides (toxic reactive oxygen intermediates).