 Although resistant strains are most frequently isolated in oral cavities, their prevalence is worrying, (Jolivet-Gougeon et al., 2008; Sixou et al., 2006).The CfxA broad spectrum beta- lactamases (CfxA, CfxA2 and CfxA3) belong to the group 2e of Bush classification.This class includes beta-lactamase enzymes with significant activity against cephalosporins and monobactams, rather than penicillins.