 A small minority of people spontaneously present a rash, usually on the arms or trunk, which can be macular (morbilliform) or papular.Almost all people given amoxicillin or ampicillin eventually develop a generalized, itchy maculopapular rash, which however does not imply that the person will have adverse reactions to penicillins again in the future.Occasional cases of erythema nodosum and erythema multiforme have been reported.