 De Orellana's voyages served as partial inspiration for the film "Aguirre, the Wrath of God" (1972).An earlier script, penned by director Werner Herzog, also deliberately included De Orellana in the movie, but he was ultimately left out.De Orellana's role in the search for "El Dorado" also forms part of the plot of the film "Indiana Jones and the Kingdom of the Crystal Skull" (2008).