 Lafe is located in northern Greene County at (36.204987, -90.507041).It is in the valley of Big Creek on the western side of Crowley's Ridge, with Big Creek flowing northwest towards the Black River.Arkansas Highways 135 and 34 intersect in Lafe; Highway 135 leads north to U.S. Route 62 east of Corning and south to Paragould, the Greene County seat, while Highway 34 leads east to Marmaduke.