 In the view of the evolutionary biologist Eugene Koonin in 2009, the modern synthesis will be replaced by a 'post-modern' synthesis that will include revolutionary changes in molecular biology, the study of prokaryotes and the resulting tree of life, and genomics.Charles Darwin's 1859 book "On the Origin of Species" was successful in convincing most biologists that evolution had occurred, but was less successful in convincing them that natural selection was its primary mechanism.In the 19th and early 20th centuries, variations of Lamarckism (inheritance of acquired characteristics), orthogenesis (progressive evolution), saltationism (evolution by jumps) and mutationism (evolution driven by mutations) were discussed as alternatives.