 American Greetings, a privately owned American company which is the world's largest greeting card producer, opened in Osceola in 1961 as the largest manufacturing facility under one roof in Arkansas.The plant occupies 2.6 million square feet or 60 acres and is the largest employer in Mississippi County.In 2017, Big River Steel, a $1.3 billion Flex Mill focused on producing flat-rolled steel for the automotive oil and gas, and electrical energy industries, opened in Osceola, after being announced in 2013.