 He developed it from J. M. Baldwin's 1902 concept that changes induced by the environment will ultimately be replaced by hereditary changes (including the Baldwin effect on behaviour), following that theory's implications to their Darwinian conclusion, and bringing him into conflict with Lysenkoism.Schmalhausen observed that stabilizing selection would remove most variations from the norm, most mutations being harmful.Dobzhansky called the work "an important missing link in the modern view of evolution".