 The alt route allows people to pass by the downtown area, as PR-3 enters into the downtown and business center of the town.Puerto Rico Highway 908 is another important highway, which begins at PR-3 and intersects PR-30 and has access to the University of Puerto Rico at Humacao, as well as some main schools.Humacao, together with San Juan and Salinas, is one of three municipalities in Puerto Rico that has controlled-access highways leaving its boundaries in all directions (in this case north to Naguabo and south to Yabucoa via PR-53 and west to Las Piedras via PR-30)

There are 68 bridges in Humacao.