 CoQ10 levels also may be affected by other genetic defects (such as mutations of mitochondrial DNA, "ETFDH", "APTX", "FXN", and "BRAF", genes that are not directly related to the CoQ10 biosynthetic process).Some of these, such as mutations in "COQ6", can lead to serious diseases such as steroid-resistant nephrotic syndrome with sensorineural deafness.Some adverse effects, largely gastrointestinal, are reported with very high intakes.