 A 1995 review study found that there is no clinical benefit to the use of CoQ10 in the treatment of periodontal disease.Most of the studies suggesting otherwise were outdated, focused on in vitro tests, had too few test subjects and/or erroneous statistical methodology and trial setup, or were sponsored by a manufacturer of the product.A review of the effects of CoQ10 supplementation in people with CKD was proposed in 2019.