 Culture fibroblasts can be used also to evaluate the rate of endogenous CoQ10 biosynthesis, by measuring the uptake of 14C-labelled "p"-hydroxybenzoate.It has been suggested that the myotoxicity of statins is due to impairment of CoQ biosynthesis, but the evidence supporting this was deemed controversial in 2011.While statins may reduce coenzyme Q10 in the blood it is unclear if they reduce coenzyme Q10 in muscle.