 These include the extracranial arteries, middle meningeal artery, large veins, venous sinuses, cranial and spinal nerves, head and neck muscles, the meninges, falx cerebri, parts of the brainstem, eyes, ears, teeth and lining of the mouth.Pial arteries, rather than pial veins are responsible for pain production.Headaches often result from traction to or irritation of the meninges and blood vessels.