 In the United States, Lundbeck manufactures and supplies Panhematin for infusion.Heme arginate (NormoSang) is used during crises but also in preventive treatment to avoid crises, one treatment every 10 days.Any sign of low blood sodium (hyponatremia) or weakness should be treated with the addition of hematin, heme arginate, or even tin mesoporphyrin, as these are signs of impending syndrome of inappropriate antidiuretic hormone (SIADH) or peripheral nervous system involvement that may be localized or severe, progressing to bulbar paresis and respiratory paralysis.