 Prazosin, an alpha-1 adrenergic antagonist, has been used in veterans with PTSD to reduce nightmares.Studies show variability in the symptom improvement, appropriate dosages, and efficacy in this population.Glucocorticoids may be useful for short-term therapy to protect against neurodegeneration caused by the extended stress response that characterizes PTSD, but long-term use may actually promote neurodegeneration.