 Chloride is found as an electrolyte, can flow through chloride channels (including the GABAA receptor) and is transported by KCC2 and NKCC2 transporters.Chloride is usually (though not always) at a higher extracellular concentration, causing it to have a negative reversal potential (around -61 mV at 37 degrees Celsius in a mammalian cell).Chloride is an essential electrolyte, trafficking in and out of cells through chloride channels and playing a key role in maintaining cell homeostasis and transmitting action potentials in neurons.