 He was a delegate to the state convention that ratified the United States Constitution in 1788.In 1791, he served a year in the Second United States Congress as a Representative of Georgia's 1st congressional district.<ref></ref> A House committee determined that electoral fraud had been committed in the 1790 election, and Wayne lost his seat over his residency qualifications.A special election was held on July 9, 1792, sending John Milledge to fill Wayne's vacant seat, and Wayne declined to run for re-election in 1792.<ref>"United States Congressional Elections, 1788–1997