 In 1897, an unfermentable product obtained by treatment of fructose with bases, in particular lead(II) hydroxide, was given the name glutose and was claimed to be a 3-ketohexose.However, subsequent studies showed that the substance was a mixture of various other compounds.The unequivocal synthesis and isolation of a 3-ketohexose, "xylo"-3-hexulose, through a rather complex route, was first reported in 1961 by G. Yuen and J. Sugihara.