 Mutations in the intracellular part of this receptor are also associated with certain types of leukemia.In clinical medicine, there is a suggestion that use of GCSF should be avoided, at least in children and adolescents and perhaps adults, when G-CSFR isoform IV is overexpressed.Granulocyte colony-stimulating factor receptor has been shown to interact with Grb2, HCK and SHC1.