 A geneticist named Miguel O'Hara gained his spider-like powers from a gene-splicing incident, when the company he was about to quit injected him with a dangerous drug called Rapture.He tried to rid himself of the drug by using the Gene Slicer he helped to invent, but unbeknownst to him a jealous co-worker had set it to repeat the previous experiment of a spider.The last time they had tried this experiment it killed the test subject (the main reason Miguel O'Hara quit), but this time it worked.