 The axon and encapsulating connective tissue lose their continuity.The last (extreme) degree of neurotmesis is transsection, but most neurotmetic injuries do not produce gross loss of continuity of the nerve but rather internal disruption of the architecture of the nerve sufficient to involve perineurium and endoneurium as well as axons and their covering.Denervation changes recorded by EMG are the same as those seen with axonotmetic injury.