 When bound, the structure of cardiolipin and β2-GP1 both undergo large changes in structure.Within the structure of Apo-H is a stretch of positively charged amino acids (protein sequence positions 282-287), Lys-Asn-Lys-Glu-Lys-Lys, are involved in phospholipid binding (see image on right).β2-GP1 has a complex involvement in agglutination.