 On November 27, 2010, Campbell lost an eight-round decision on the Juan Manuel Márquez undercard in Las Vegas to Walter Estrada, a journeyman whose record included only three wins over winless fighters in twelve bouts between 2008–2010.On November 29, 2010, Nate Campbell announced his retirement from boxing.On April 21, 2011 Nate came out of retirement to fight unbeaten Danny Garcia losing a Unanimous Decision.