 Among his maternal relatives was aunt Naticia Yznaga (wife of Sir John Lister-Kaye, 3rd Baronet), and uncle Fernando Yznaga (husband of Jennie Smith, sister of Alva Smith Vanderbilt Belmont).He was educated at Eton and Trinity College, Cambridge.Manchester succeeded his father in the dukedom in 1892 at the age of fifteen, and took his seat on the Liberal benches in the House of Lords in June 1902.