 Transferred from this see to that of Trani (Southern Italy) in 1439, he remained archbishop of Trani after his elevation to the cardinalate by Pope Nicholas V on 20 December 1448.In 1450, the Archbishopric of Urbino was conferred upon him, which made it possible for him to take up his residence in Rome, the See of Trani being given to his brother, Giovanni Orsini, Abbot of Farfa.Pope Paul II appointed him papal legate for the Marches.