 Pope Sixtus IV, for whose election in 1471 Cardinal Latino had worked energetically, named him Camerlengo of the Holy Roman Church, granted him in 1472 the Archdiocese of Taranto, which he governed by proxy, and, in addition, placed him at the head of the government of the Papal States.He was also appointed commander-in-chief of the papal fleet in the war against the Turks, and, acting for the pope, crowned Ferdinand I of Naples.He founded in Rome the monastery of S. Salvatore in Lauro, which he richly endowed and in which he established the canons regular, donating to it also numerous manuscripts.