 Deletion of two adjacent genes with a high degree of homology to complement factor H, named complement factor H-related 3 and complement factor H-related 1, protects against age-related macular degeneration because of reduced competition for binding of CFH to vascular surface binding sites.A rare functional coding change, R1210C, in this gene results in a very high risk of macular degeneration.Alterations in the immune response are involved in pathogenesis of many neuropsychiatric disorders including schizophrenia.