 Confronted with this hostile reception Isotta appears to have decided that devoting herself to literary studies meant the sacrifice of friendship, fame, comfort, and sexuality, and in 1441 returned to her property at Verona to live quietly, possibly with the company of her mother.She cut short her career as a secular humanist and turned instead to the study of sacred letter.Here it was that in 1451 that she published her most famous and perhaps most influential work "De pari aut impari Evae atque Adae peccato ("trans.