 Some patients also experience hypertension and edema.Severe disease is characterized by pronounced oliguria or anuria, which portends a poor prognosis.It is thought that antineutrophil cytoplasmic antibodies (ANCA) interact with antigens in the cytoplasm of neutrophils to cause an early degranulation, triggering the release of lytic enzymes at the site of injury and leading to the formation of "glomerular crescents" that consist primarily of parietal epithelial cells from Bowman's capsule and in some cases podocytes.