 In mammals, such endogenous rhythms are generated by the suprachiasmatic nucleus (SCN) of the anterior hypothalamus.Entrainment is accomplished by altering the concentration of clock components through altered gene expression and protein stability.Circadian oscillations occur even in the cells of isolated organs such as the liver/heart as peripheral oscillators, and it is believed that they sync up with the master pacemaker in the mammalian brain, the SCN.