 Autoimmunity is also being studied in this regard.Linkage between XRCC4 mutations and certain pathologies may provide a basis for diagnostic biomarkers and, eventually, potential development of new therapeutics.XRCC4 polymorphisms have been linked to a risk of susceptibility for cancers such as bladder cancer, breast cancer, prostate cancer, hepatocellular carcinoma, lymphomas, and multiple myeloma.