 This impairs hemagglutinin intracellular trafficking and insertion of the protein into the host plasma membrane.Nitazoxanide modulates a variety of other pathways "in vitro", including glutathione-S-transferase and glutamate-gated chloride ion channels in nematodes, respiration and other pathways in bacteria and cancer cells, and viral and host transcriptional factors.Following oral administration, nitazoxanide is rapidly hydrolyzed to the pharmacologically active metabolite, tizoxanide, which is 99% protein bound.