 These procedures are often intended as definitive surgical treatment of a disease in which the diagnosis is already known or strongly suspected.However, pathological analysis of these specimens is critically important in confirming the previous diagnosis, staging the extent of malignant disease, establishing whether or not the entire diseased area was removed (a process called "determination of the surgical margin", often using frozen section), identifying the presence of unsuspected concurrent diseases, and providing information for postoperative treatment, such as adjuvant chemotherapy in the case of cancer.In the determination of surgical margin of a surgical resection, one can use the bread loafing technique, or CCPDMA.