 On 31 August 2009 Domínguez was called by coach Diego Maradona for the Argentine national team, along fellow Vélez Sársfield teammates Nicolás Otamendi and Emiliano Papa.With Argentina, the defender started the World Cup qualifier games against Brazil and Paraguay (both defeats for Argentina).Domínguez was later called by coach Alejandro Sabella for the 2011 and 2012 editions of the friendly competition Superclásico de las Américas, in which he captained the national team.