 Route 66 connects the western Hampshire County towns of Huntington, Westhampton, and Northampton and passes through Smith College at its eastern end.Route 66 begins at Route 112 (Worthington Road) next to the Eastern Branch of the Westfield River in the village of Knightville in the town of Huntington.The two-lane highway heads east as Pond Brook Road, which follows the namesake stream to the village of Norwich then ascends Norwich Hill.