 Tizoxanide is then glucuronide conjugated into the active metabolite, tizoxanide glucuronide.Peak plasma concentrations of the metabolites tizoxanide and tizoxanide glucuronide are observed 1–4 hours after oral administration of nitazoxanide, whereas nitazoxanide itself is not detected in blood plasma.Roughly of an oral dose of nitazoxanide is excreted as its metabolites in feces, while the remainder of the dose excreted in urine.