 Sanford married twice, first to Elizabeth Webb, who at one time lived at Groton Manor, the home of John Winthrop in England; this marriage produced two children.Following Elizabeth's death, Sanford married Bridget, the daughter of William Hutchinson and his famous wife, Anne (Marbury) Hutchinson, this marriage producing nine children, many of whom died young.William Hutchinson served for one year as the Judge (Governor) of Portsmouth.