 In collaboration with the organic chemist John Harley-Mason and Humphry Osmond, his psychiatric colleague at St. George's, he developed this idea, into the first specific biochemical theory of schizophrenia—the transmethylation hypothesis (5).Inspired by the fact that mescaline produces such remarkable effects on all human mental faculties and by the interdisciplinary work of Albert Schweitzer, in the same year Smythies decided to tackle the mind-brain problem in a systematic way i.e.by undertaking a rigorous training in neuroscience, experimental psychology and philosophy.