 His wife, Abigail Lydia Mott died of tuberculosis on September 4, 1846 at the age of 51.At the time, the family was living at 5 Elizabeth Street in Rochester, N.Y.

By 1848, Moore was appointed Principal of Haverford College, a post-secondary Quaker institution.According to his student, Richard Wood, "He was a portly man of commanding height and mien, of benevolent countenance and expressive features.