 On 10 February 1944, ten days after a fire in her engine room had swept one man overboard and forced her to return to base, "U-450" left Toulon for the Italian coast, presumably to attack support ships coming to reinforce Allied troops which had just landed at Anzio.In March 1944, exactly one month later, she came under depth charge attack by the British escort destroyers , , and and the American escort destroyer .The submarine sank, at position , but all 51 crew members were rescued by the destroyers and became prisoners of war.