 His brother-in-law, Richard Mott, was elected as an Opposition Party candidate to the Thirty-fourth and reelected as a Republican to the Thirty-fifth Congresses (March 4, 1855 – March 3, 1859).His wife, Abigail Lydia Mott died of tuberculosis on September 4, 1846 at the age of 51.At the time, the family was living at 5 Elizabeth Street in Rochester, N.Y.

By 1848, Moore was appointed Principal of Haverford College, a post-secondary Quaker institution.