 She was a daughter of the High Priest of Amun Nimlot C and the lady Tentsepeh C. Her paternal grandparents were pharaoh Osorkon II and queen Djedmutesankh.Karomama married pharaoh Takelot II and was mother of pharaoh Osorkon III.Karomama also was the grandmother of both pharaohs Takelot III and Rudamun and of the God's Wife of Amun Shepenupet I
Karomama is known from the "Chronicle of Osorkon B" at Karnak and the Nile Quay Texts dating to the reign of her son Osorkon III.