 On 4 July 2016, De Roon signed for newly-promoted Premier League side Middlesbrough for a reported £12 million transfer fee.He scored his first goal for his new club – a 91st-minute equaliser – on 5 November 2016 in a 1–1 draw with Manchester City at the Etihad Stadium.He went on to score a further 3 league goals for the club over the remainder of the season, including the only goal in a victory over Sunderland in the Tees–Wear derby, however Middlesbrough were relegated on 8 May 2017.