 The diagnosis of EoE is typically made on the combination of symptoms and findings on diagnostic testing.Prior to the development of the EE Diagnostic Panel, EoE could only be diagnosed if gastroesophageal reflux did not respond to a six-week trial of twice-a-day high-dose proton-pump inhibitors (PPIs) or if a negative ambulatory pH study ruled out gastroesophageal reflux disease (GERD).Endoscopically, ridges, furrows, or rings may be seen in the esophageal wall.