 "Killing Loneliness", along with "Wings of a Butterfly", is one of the band's best known songs in the United States.On the 11 May 2006 episode of "Loveline", lead vocalist Ville Valo confirmed that the song was inspired by skateboarder Brandon Novak, who blamed his heroin addiction on a need to, as he put it, "kill the loneliness".The song is playable in the 2010 video game "Rock Band 3".