 The route crosses areas consisting of homes, forests, and farmland on its way through the hamlet of Floyd to a junction with NY 291 in the adjacent town of Marcy.Beyond this intersection, NY 365 traverses mostly open areas of the town of Trenton before it enters the village of Holland Patent, mostly based around NY 365's junction with NY 274.NY 365 continues on, crossing the isolated and sparsely populated areas that separate the villages of Holland Patent and Barneveld.