 In recent years there are some prominent proponents of saltation, including Carl Woese.Woese, and colleagues, suggested that the absence of RNA signature continuum between domains of bacteria, archaea, and eukarya constitutes a primary indication that the three primary organismal lineages materialized via one or more major evolutionary saltations from some universal ancestral state involving dramatic change in cellular organization that was significant early in the evolution of life, but in complex organisms gave way to the generally accepted Darwinian mechanisms.The geneticist Barbara McClintock introduced the idea of "jumping genes", chromosome transpositions that can produce rapid changes in the genome.