 Prust was drafted by the Calgary Flames in third round, 70th overall, at the 2004 NHL Entry Draft, where he was sent back down to London to play his final OHL season.After spending the following season with the Omaha Ak-Sar-Ben Knights, Prust made his NHL debut on November 1, 2006, against the Detroit Red Wings.Prust suffered an injury during the 2008–09 season when he broke his jaw after being elbowed by Cam Janssen of the St. Louis Blues.