 Most often, the drug in question is powdered and placed in the mouth (often directly under the tongue).If held there long enough, the drug will diffuse into the blood stream, bypassing the GI tract.This may be a preferred method to simple oral administration, because MAO is known to oxidize many drugs (especially the tryptamines such as DMT) and because this route translates the chemical directly to the brain, where most psychoactives act.