 HPV is not alone enough causative.Of the over 100 different types of HPV, approximately 40 are known to affect the epithelial tissue of the anogenital area and have different probabilities of causing malignant changes.A test for HPV called the Digene HPV test is highly accurate and serves as both a direct diagnosis and adjuvant to the all-important Pap smear, which is a screening device that allows for an examination of cells but not tissue structure, needed for diagnosis.