 The First Nation is affiliated with the Saskatoon Tribal Council, along with six other First Nations.The First Nation takes its name from the name of its first chief, Chief Mistawasis.Mistawasis, or "Big Child" in English, was the first person to sign Treaty 6 in 1876.

Notable people of the Mistawasis Nation include Marion Buller, a judge in British Columbia who heads the National Inquiry into Missing and Murdered Indigenous Women.