 One drawback, however, is tooth discoloration and decay caused by long-term use of this method with acidic or otherwise caustic drugs and fillers.In addition to Salvinorin A, other psychoactives may also be applied sublingually.LSD, MDMA, morphine, alprazolam, clonazepam, Valium, and many other substances including the psychedelic tryptamines and phenethylamines are all viable candidates for administration via this route.