 She has done many popular roles in Indian soap operas, most notably "Ram Milaayi Jodi", and also "Uttaran" etc.In 2015, she played the pivotal role of Shanti Devi in the Star Plus serial "Mere Angne Mein".Krutika Desai and her husband Imtiaz Khan (brother of actor Amjad Khan) has a daughter Ayesha Khan.