 It begins at the intersection of Erie Boulevard and State Street (New York State Route 5 or NY 5) in Schenectady and follows Erie Boulevard and Maxon Road out of the city.Now in the town of Niskayuna, the byway runs alongside the Mohawk River as it follows County Route 10 (CR 10) northeast to a junction with NY 146 in the hamlet of Aqueduct.CR 10 ends here; however, the Mohawk Towpath Scenic Byway turns north to cross the Mohawk River and enter Saratoga County by way of NY 146.