 Carbidopa/levodopa/entacapone is contraindicated in patients taking a class of antidepressant drugs known as non-selective monoamine oxidase (MAO) inhibitors such as phenelzine and tranylcypromine.Combining carbidopa/levodopa/entacapone with these drugs could cause serious—possibly life-threatening—side effects.MAO inhibitors should be stopped at least two weeks before starting therapy with carbidopa/levodopa/entacapone.