 On 19 September 1957, its name was changed to the Apostolic prefecture of Prome.On 21 February 1961, the prefecture was elevated to a full bishopric as Diocese of Prome.Finally on 8 October 1991, the diocese was renamed the Diocese of Pyay and became a suffragan of the Archdiocese of Yangon

The resignation for health reasons of Auxiliary Bishop Gregory Taik Maung, appointed in 1991, who was serving as Apostolic Administrator, was accepted by Pope Benedict XVI on Friday, July 16, 2010.