 The median time to first return to sinus rhythm after administration of landiolol was 14 hours, and the median highest infusion rate was 3 μg/kg/min .Landiolol is a promising drug to manage postoperative atrial fibrillation in non-cardiac surgery with a profile that allow for control of heart rate with minimal impact on blood pressure.Landiolol has limited negative inotropic effect and is well tolerated by the respiratory system.