 "UBE3A" codes for an E6-AP ubiquitin ligase, which chooses its substrates very selectively, and MAPK1, PRMT5, CDK1, CDK4, β-catenin, and UBXD8 have been identified as ubiquitination targets of this protein.The electroencephalogram (EEG) in AS is usually abnormal, more so than clinically expected.This EEG facilitates the differential diagnosis of AS, but is not pathognomonic.