 Lord Irvine served as Governor of Kingston-upon-Hull from 1715 until his death from smallpox in 1721, four years after their marriage.Anne, who had no children with her first husband, traveled by herself to the Netherlands and France in 1730, and in 1736, she became an attendant of the Princess of Wales, Augusta of Saxe-Gotha, wife of Frederick, Prince of Wales and, later, mother of King George III.It was not until 1737 that Anne remarried, after sixteen years of widowhood.