 Hussey was born in Sleaford, Lincolnshire, England, son of Sir William Hussey, an English judge and Chief Justice of the King's Bench.His mother was the former Elizabeth Berkeley.Hussey's siblings included Sir Robert Hussey (d. 1546), the father of Elizabeth Hussey, the 'Mistress Crane' at whose home at East Molesey the first of the Marprelate tracts, Martin's "Epistle", was printed in October 1588; Elizabeth Hussey, who married Richard Grey, 3rd Earl of Kent; and Mary Hussey, who married William Willoughby, 11th Baron Willoughby de Eresby.