 PA 741 was designated by 1930 to run from PA 41 north to US 30 in Gap.In the 1930s, PA 41 and PA 741 switched alignments, with PA 741 running between US 222 in Lampeter and PA 41 in Gap and PA 41 heading north to US 30.PA 741 was extended west to PA 324 south of New Danville in the 1970s.