 Johnny Marzetti originated in Columbus, Ohio at Marzetti's, an Italian restaurant established in 1896 at Woodruff Avenue and High Street by an Italian immigrant named Teresa Marzetti.One of the dishes Marzetti offered her customers was a baked casserole of ground beef, cheese, tomato sauce, and noodles that she named for her brother-in-law, Johnny.Teresa Marzetti was the first person to serve the casserole Johnny Marzetti in a restaurant.