 PA 741 forms a concurrency with U.S. Route 222 (US 222) between Willow Street and Lampeter before it continues east through farmland in the Pennsylvania Dutch Country that is home to several Amish families, passing through Strasburg before reaching Gap.The section of road between Willow Street and Lampeter was designated as part of US 230 in 1926 and concurrent with PA 72 in 1927, with US 222 replacing US 230 by 1928.In 1928, the road between Willow Street and Gap became part of PA 41.