 During the reign of Stuart monarch James I, Tyrone would be reduced further with the barony of Loughinsholin in its north-east being transferred to the new county of Londonderry.The Ó Néill rebelled several times, attempts to reassert sovereignty.The last attempt of substance was under Aodh Mór Ó Néill, Earl of Tyrone, who fled in 1607 in what became known as the Flight of the Earls, where he and many of his allies (particularly among Ulster Gaeldom) fled Ireland.