 The organolithium reagents used in this transformation can be commercial (such as n-butyllithium) or can be generated through deprotonation or lithium halogen exchange.Both inter- and intramolecular examples of carbolithiation exist and can be used in synthesis to generate complexity.Organolithiums are highly reactive chemicals and often the resulting organolithium reagent generated from the carbolithiation can continue to react with electrophiles or remaining starting material (resulting in polymerization).