 The second step completing tamoxifen is a Suzuki reaction.As a consequence of the high reactivity of organolithiums as strong bases and strong nucleophiles, the substrate scope of the carbolithiation is generally limited to chemicals that do not contain acidic or electrophilic functional groups.Due to the decreased nucleophilicity of Grignard reagents (organomagnesium reagents) and organozinc reagents, non-catalyzed carbomagnesiation and carbozincation reactions are typically only observed on activated or strained alkenes and alkynes.