 In 2015, after struggles from setup man Jonathan Broxton, Jeffress took over as the eight-inning man for Milwaukee.In 2016, Jeffress was slated to be Milwaukee's setup man to closer Will Smith but before spring training could begin, Jeffress was named closer when Smith suffered a knee injury.On August 1, 2016, the Brewers traded Jeffress and Jonathan Lucroy to the Texas Rangers for Lewis Brinson, Luis Ortiz, and a player to be named later.