 During their time in exile Trebizond witnessed palace revolutions, both in Trebizond and in the Constantinople.The Byzantine regency government of John V Palaiologos supported her late husband's uncle Michael of Trebizond and also Basil's cousin John III of Trebizond in their power bids for power in Trebizond, but when John VI Kantakouzenos won the Byzantine civil war, he lent his support to a power bid on the behalf of Irene's son John.Her other son Alexios is not mentioned after his departure from Trebizond and may have died soon after arriving in Constantinople.