 Tamekage then engaged Uesugi Akisada, and defeated him as well, with the help of Hōjō Sōun, another growing power in the region.Within a few years, Nagao and Hōjō brought about the complete collapse of the Uesugi clan.He was defeated and killed in the 1536 Battle of Sendanno against the Ikkō-ikki of Kaga Province.