 Mesembrine

Mesembrine is an alkaloid present in "Sceletium tortuosum" (kanna).It has been shown to act as a serotonin reuptake inhibitor (Ki = 1.4 nM), and more recently, has also been found to behave as a weak inhibitor of the enzyme phosphodiesterase 4 (PDE4) (Ki = 7,800 nM).