 Transcription of glucose 6-phosphatase subsequently decreases, which consequently decreases the rates of gluconeogenesis and glycogenolysis.FOXO1 also activates transcription of phosphoenolpyruvate carboxykinase, which is required for gluconeogenesis.The activity of FOXO1 is also regulated through CBP induced acetylation on Lys-242, Lys-245, and Lys-262.