 It is so named because of the characteristic intracytoplasmic inclusions that are observed in clinical examinations in epidermal cells, oral mucosal epithelial cells, visceral epithelial cells, and neurons.In the 1970s and 1980s, the disease was most commonly observed in Burmese pythons ("Python bivittatus").From the 1980s on, it has been most commonly observed in boa constrictors.