 From 1943 through 1970, Constantine worked in the architecture and design department of the Museum of Modern Art, as associate curator and later as curatorial consultant, where she helped popularize collections that were hard to categorize or had been ignored, which she called "fugitive material".Her 1948 exhibition "Polio Posters" was the museum's first devoted to causes, and included works she commissioned to help spread awareness of various social issues.She organized solo exhibitions for graphic and product designers including Alvin Lustig, Bruno Munari, Massimo Vignelli and Tadanori Yokoo that were described by "The New York Times" as "career-defining."