 Grafting skin wounds with IntegraTM leads to the synthesis of normal vascularized and innervated dermis de novo, followed by re-epithelization and formation of epidermis.Although early versions of the scaffold were not capable of regenerating hair follicles and sweat glands, later developments by S.T Boyce and coworkers led to solution of this problem.The mechanism of regeneration using an active collagen scaffold has been largely clarified.